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Review
Biology and Life Sciences
Life Sciences

Colby Renshaw

,

Yingguang Liu

Abstract: Reports of viable microorganisms from ancient halite create an unusual test of the biological limits of cellular survival. Halite deposits can be tens to hundreds of millions of years old, and increasingly rigorous studies have used chemical surface sterilization, petrographic selection of primary crystals, and direct sampling of primary fluid inclusions to reduce the likelihood of modern contamination. Nevertheless, the geological age of a crystal or inclusion does not by itself establish the age of a recovered organism. The central problem is that both major interpretations remain difficult. Modern contamination becomes less satisfactory when microorganisms are recovered from deeply buried, carefully sterilized primary material, yet uninterrupted survival for geological intervals is difficult to reconcile with spontaneous DNA and protein damage, ionizing radiation, finite energy supplies, and observed loss of microbial viability in other long-term environments. A further problem is molecular: several putatively ancient isolates or sequences are remarkably similar to modern organisms despite host-rock ages of tens to hundreds of millions of years. Proposed explanations include contamination, later recrystallization or groundwater infiltration, extremely low-activity maintenance states, and underestimation of genomic divergence by conserved markers such as 16S rRNA. None currently explains all observations. Ancient halite therefore provides a natural extreme-case model for a broader biomedical question: how long can a cell preserve sufficient molecular integrity for recovery when metabolism, repair, and replacement of damaged components approach their lower limits?

Article
Social Sciences
Language and Linguistics

Viktor Balabin

,

Volodymyr Lisovskyi

Abstract: The purpose of this article is to actualize the research tasks of military-technical translation/interpreting as one of the three primary functional-pragmatic sub-types of military translation/interpreting. Despite numerous academic publications addressing the theoretical issues of military-technical translation/interpreting, its foundational conceptual provisions remain insufficiently developed and lack definitive formalization as structured theoretical constructs. It is necessary to summarize and analyze academic publications, educational and methodological works, regulatory documents, reference materials, and the practical application of military-technical translation/interpreting spanning the period of 1993–2026. Furthermore, it is essential to substantiate the theoretical and conceptual basis of military-technical translation/interpreting by delineating its object, subject matter, purpose, tasks, conceptual framework, and the specificity of its execution within the system of linguistic support for military forces. Other priority research tasks concerning military-technical translation/interpreting include: investigating the genre-stylistic specificity of military-technical texts; providing an academic description of various types of military-technical texts and developing their typology; systematizing the lexico-semantic and grammatical-syntactic difficulties inherent in military-technical translation/interpreting; determining the scope of the military-terminological (normative-codifying) activity of the military translator/interpreter; and refining the content and definitions of specialized terms, ultimately culminating in the compilation of an appropriate glossary.

Review
Biology and Life Sciences
Neuroscience and Neurology

Mohamed TawfiK

Abstract: Microglia encounter combinations of soluble, target-bound and physical signals whose functional meaning changes with spatial presentation, timing and the state of the receiving cell. Yet most mechanistic studies isolate one receptor or ligand at a time. This review defines direct functional interaction as experimentally demonstrated effect modification between specified inputs in the same functional setting, and distinguishes it from sequential or multicellular relays, context dependence, association and hypothesis. The literature is organized around five linked decisions: positioning and stable contact, target recognition, uptake or restraint, cargo degradation and recovery, and later cellular state or output. Noradrenergic opposition to ATP-directed process extension provides a direct interaction; neuron-microglia-astrocyte and injury-induced ATP-IL-1β circuits provide directional relays. Complement, phosphatidylserine, inhibitory checkpoints, trophic signals, mechanosensing, age, sex and anatomical niche instead show how individual pathways and context shape particular decisions without necessarily demonstrating cue-cue integration. Direct multi-input experiments remain uncommon. Human single-cell and spatial studies can identify candidate states and signalling niches, but observational data cannot by themselves establish ligand access, receptor function, direction or causal interaction. Claims are therefore described as direct interactions, relays, context-dependent effects or associations according to the experiment that supports them. Therapeutically, this matters because a pathway that contributes to pathology in one setting may support surveillance, clearance, vascular stability or repair in another.

Article
Computer Science and Mathematics
Artificial Intelligence and Machine Learning

Bishal Majumder

,

Ritwik Dash

,

Mamata Jenamani

Abstract: Traditional credit risk assessment commonly treats borrowers as independent tabular records, overlooking shared geographic and occupational stress that can produce correlated repayment outcomes. We present a reproducible socio-spatial dataset benchmark and testbed for explainable default risk prediction that represents borrowers as nodes in a structured relational network. The benchmark constructs weighted homophily links from observable pre-target attributes and derives structural centrality, community, and multi-hop neighborhood-stress features. A multi-head Graph Attention Network (GAT) learns relational representations that are exported to a downstream tree-based classifier, allowing graph signals to be compared with individual borrower attributes. We evaluate logistic, ensemble, graph feature proxy, and full graph feature models under a stratified protocol, and use ablation analysis to examine the contribution of relational information. The testbed provides a larger-scale experimental framework for studying graph construction, relational representation learning, downstream risk classification, explainability, and computational growth under a common reproducible pipeline. The framework also combines SHAP feature-group attribution with GAT edge attention to provide complementary global and relational explanations. A scalability analysis studies the computational behavior of the downstream evaluation as the benchmark grows. The results support controlled experiments in relational stress modeling while highlighting the limitations of synthetic data. The benchmark is not intended to establish causal contagion, demographic fairness, or regulatory compliance.

Article
Physical Sciences
Condensed Matter Physics

E.I. Kats

Abstract: The discovery of the twist-bend nematic phase in liquid crystals composed of bent-core and dimeric molecules has revealed an unexpected mechanism for the spontaneous formation of nanoscale periodic structures in soft condensed matter. Unlike conventional liquid-crystalline phases, the twist-bend phase (NTB) exhibits a nanoscale heliconical modulation despite the absence of molecular chirality. In this note, dedicated to the late R. Meyer, we discuss a Landau phenomenological interpretation of this phenomenon. The central idea is that a short-range orientational order parameter undergoes condensation, giving rise to a heliconical structure characterized by a finite wave vector. We emphasize that the conventional nematic order is already long-ranged, whereas the additional order parameter describes local orientational correlations hidden within the nematic state. The resulting phase transition bears a close analogy to the de Gennes theory of the nematic–smectic-A transition. Fluctuation effects are expected to drive the transition weakly first order. The theory also predicts a new Goldstone mode associated with the spontaneously broken continuous symmetry of the heliconical state.

Review
Environmental and Earth Sciences
Geophysics and Geology

Mónica Arias

,

Pablo Gumiel

,

Agustin Martin-Izard

Abstract: Antimony (Sb) is a critical raw material whose European supply depends strongly on imports, renewing interest in the metallogenic framework of historical Sb provinces. This review compiles and reassesses 100 Sb deposits and occurrences from Spain and Portugal within a unified geological, structural, and mineralogical framework. Six broad deposit types and twelve mineral associations are recognized, with the Central Iberian Zone containing the largest number and greatest diversity of occurrences. The regional distribution of mineralization indicates a hierarchical control in which long-lived Variscan shear zones and crustal faults organized hydrothermal circulation, whereas second-order fractures, breccias, and favorable lithological or stratigraphic horizons localized ore deposition. Vein-type and stratabound mineralization are therefore interpreted as potentially related expressions of evolving tectono-hydrothermal systems rather than necessarily distinct genetic families. Gold-bearing Sb systems are particularly developed in western Iberia, whereas carbonate-hosted Sb-Hg mineralization characterizes the Cantabrian Zone and Sb-Cu associations are prominent in the South Portuguese Zone. An integrated multistage model is proposed in which heterogeneous pre-ore metal reservoirs, Variscan crustal architecture, late Variscan reactivation, magmatic and thermal activity, and local structural-lithological traps collectively controlled Sb mobilization and deposition. The model emphasizes repeated tectono-hydrothermal reactivation rather than a single universal metal or fluid source.

Article
Medicine and Pharmacology
Orthopedics and Sports Medicine

Ádám Fésüs

,

Leila Bogdán

,

Ivett Majoros

,

Judit Prókai

,

Balázs Sebesi

,

Patrik Ivusza

,

Balázs Gáspár

,

Tibor Hortobágyi

,

Márk Váczi

Abstract: Dynamic knee valgus (DKV) is commonly used in functional screening related to anterior cruciate ligament (ACL) injury risk; however, assessments often rely on peak valgus alone despite the combined influence of knee valgus and flexion on knee loading. This study compared knee kinematics and vertical ground reaction forces (GRFs) between single-leg landing (SLL) and single-leg countermovement jump (SL-CMJ), focusing on peak knee valgus, knee flexion at peak valgus, valgus angular velocity, knee flexion-normalized valgus, and GRFs. Physically active, asymptomatic female participants (n = 30) performed both the SLL and SL-CMJ tasks. Knee kinematics and GRFs were recorded using motion-tracking sensors and a force platform. Peak knee valgus did not differ between tasks. Compared with SL-CMJ, SLL produced 24% less knee flexion at peak valgus, 17% greater knee flexion-normalized valgus, 254% higher valgus angular velocity, and 124% higher GRFs (all p < 0.05). These findings demonstrate task-dependent differences in landing mechanics that are not captured by peak knee valgus alone. Assessing knee valgus together with knee flexion and its temporal development may provide a more comprehensive characterization of potentially relevant knee-loading mechanics. The high valgus angular velocities observed during SLL may also inform the development of velocity-specific neuromuscular training strategies.

Article
Computer Science and Mathematics
Geometry and Topology

Xing-Yu Hu

Abstract: Let \(X\) be a Tychonoff space and let \(bX\) be a Hausdorff compactification of \(X\). We study the boundary-approach density \(d_b^{\partial}(X)\), an embedding-sensitive cardinal measuring how small a single subset of \(X\) can be while its closure reaches the whole remainder. We examine its behavior under products and as the compactification varies. For a non-empty family \((X_i)_{i\in I}\) of non-empty Tychonoff spaces with Hausdorff compactifications \(b_iX_i\), put \(P=\prod_{i\in I}X_i\) and \(K=\prod_{i\in I}b_iX_i\). We obtain an exact trichotomy. If all factors are compact, the value is \(0\). If exactly one factor is non-compact, the value is the maximum of the boundary-approach density of that factor and the density of the remaining compact product. If at least two factors are non-compact, the value is exactly \(\text{dens}(P)\), independently of the chosen factor compactifications. For a non-compact locally compact Tychonoff space \(X\), the one-point and Stone–Čech compactifications attain the minimum and maximum of the boundary-approach spectrum. If \(X\) also admits a clopen decomposition \(X=\coprod_{\xi<\tau}G_\xi\), where \(\tau\) is infinite and each \(G_\xi\) is non-empty and non-\(\omega\)-bounded, then every infinite cardinal \(\lambda\leq\tau\) is realized by a compactification \(b_\lambda X\), and the compactifications may be chosen to form a chain in the compactification order. When \(\tau=\text{dens}(X)\), the spectrum is the full interval \(\{\lambda:\omega\leq\lambda\leq\text{dens}(X)\}\). In particular, every non-compact locally compact metrizable space has this full spectrum. We also obtain an exact closed-core formula, an intrinsic Stone–Čech characterization, the identity \(d_\beta^{\partial}(X)=\text{dens}(X)\) for non-compact metrizable \(X\), and monotonicity of \(d_\beta^{\partial}\) under continuous maps with dense image.

Article
Computer Science and Mathematics
Artificial Intelligence and Machine Learning

Jea-Kwon Lee

,

Md Ariful Islam Mozumder

,

Dae-Young Kim

,

Hee-Cheol Kim

Abstract: Fashion enterprises face demand uncertainty from seasonality, short product life cycles, and dense color-size variation: excessive ordering enlarges aged-inventory risk, whereas insufficient ordering causes stockouts. This study develops and validates a manager-assisted hybrid decision support system (DSS) integrating demand forecasting, reorder-candidate identification, aged-inventory risk detection, and ranking-based prioritization. Operational data from a Korean fashion enterprise (4,130,603 sales and 5,065,027 order records) were reconstructed into a style-level monthly panel of 263,260 observations and split chronologically into training (2012–2014), validation (2015), and test (2016) periods to prevent leakage. Three baselines and nine data-driven models, Random Forest, Histogram Gradient Boosting, LightGBM, a two-stage Hurdle LightGBM, LSTM, Transformer, TimeMixer, TimeXer, and CrossLinear, were benchmarked, their outputs then combined with current-month sales signals and an inventory-comparison rule inside the DSS. On the 2016 test data, the DSS attained a Weighted Absolute Percentage Error of 0.6477, reorder F1-score of 0.7983, Hit@50 of 47.04%, and NDCG@50 of 75.12%, a balance no single model achieved. A policy simulation indicated that DSS-guided ordering could cut inbound order quantity by 25.9% and long-term inventory risk by 23.0%, at the cost of a 39.5% rise in shortage quantity. Forecasting accuracy alone is therefore insufficient for deploying artificial intelligence in inventory decisions.

Article
Physical Sciences
Astronomy and Astrophysics

Jianchao Xue

,

Li Feng

,

Yiliang Li

,

Jean-Claude Vial

,

Jie Zhao

,

Hui Li

Abstract: Although non-LTE prominence diagnostics have been widelystudied, the impactof realistic 3D velocity fields on prominence emissions remains poorly explored. In this study, we utilize a 2D non-LTE radiative transfer code combined with a 3D MHD model to synthesize HI Lyα and Hα emissions in an eruptive prominence. Incorporating full 3D velocities into the non-LTE calculations reveals three main findings: (1) small-scale motions (∼10kms−1) produce noticeable Doppler dimming in Lyα, whereas Doppler brightening in Hα is less pronounced; (2) Lyα line-center Doppler shifts trace plasma flows in the prominence-corona transition region (PCTR), while Hα line-center shifts reflect line-of-sight integrated signals over a larger range of depths; and (3) Lyα spectral widths depend on PCTR dynamics and temperature, whereas Hα line widths are dominated by optical depth effects. Accounting for 3D velocity fields significantly complicates prominence spectral diagnostics, underscoring the need for further detailed modeling.

Communication
Chemistry and Materials Science
Organic Chemistry

Marta Fiéis

,

João Sarrato

,

Ricardo Chagas

,

Luísa Maria Ferreira

Abstract: Two previously undescribed sulfobetaine zwitterions bearing benzyl ester and amide functionalities were synthesised through a concise three-step sequence starting from benzyl alcohol and either succinic or glutaric anhydride. The route comprised esterification, amidation with N,N-dimethylpropane-1,3-diamine and ring-opening of 1,3-propanesultone by the resulting tertiary amine. Differing only in the length of the diacid-derived spacer, the two compounds constitute a matched pair well suited to probing structure–property relationships in sulfobetaine surfactants and thermoresponsive materials.

Article
Business, Economics and Management
Business and Management

Tian Yang

,

Teh Boon Heng

,

Kwan Jing Hui

Abstract: This study examines how green initiatives are associated with financial performance through a statistical transmission channel involving environmental, social, and governance (ESG) assessment and whether that channel varies across life-cycle stages. Using an unbalanced panel of 6,579 firm-year observations from 1,114 Chinese A-share firms in heavily polluting industries during 2015–2024, the analysis compares green investment, green innovation, green subsidy, and ISO 14001 certification within a common framework. Firm and year fixed-effects models with firm-clustered inference are combined with 5,000 firm-cluster bootstrap replications and Benjamini–Hochberg false-discovery-rate adjustment. All four initiatives are positively associated with Huazheng ESG ratings. ESG ratings are positively associated with ROA and ROE, whereas a positive association with Tobin’s Q is not established. Each initiative exhibits a positive statistical indirect association with ROA through ESG, although total financial associations remain heterogeneous; green subsidy shows a negative contemporaneous total association with ROA. Corporate life cycle selectively conditions the pathway: ESG-mediated associations of green investment and green subsidy are significantly stronger in growth-stage firms than in mature or declining firms, while comparable stage differences are not established for green innovation or certification. The evidence distinguishes external sustainability recognition from immediate profitability and locates life-cycle dependence in resource-deployment-intensive green actions.

Review
Computer Science and Mathematics
Computer Science

Zheng Zhang

,

Zhixiang Guo

,

Yuan Si

,

Siyuan Liang

,

Shunyu Liu

,

Weibo Gao

,

Song Wang

,

Leszek Rutkowski

,

Giuseppe Valenzise

,

Ming-Hsuan Yang

+4 authors

Abstract: World models are increasingly used to predict and simulate how environments evolve, yet their evaluation remains fragmented across video generation, autonomous driving, and robotics. World-model benchmarks differ in four respects: what capability is evaluated, how the model is evaluated, which metrics are used, and where the data come from. Thus, similar scores may reflect different evidence and should not support the same capability claims. We present an evaluation-centric survey of 102 representative benchmarks released between 2018 and 2026. We characterize them through four coupled dimensions: Evaluation Target, Evaluation Protocol, Evaluation Metrics, and Evaluation Data. Evaluation Target encompasses visual and temporal quality, spatial and state consistency, long-horizon memory and state persistence, physical plausibility, causal and counterfactual reasoning, control fidelity and interactive dynamics, and functional utility. Our analysis reveals that evaluation targets are expanding beyond visual and temporal quality toward functional utility, while corresponding protocols, metrics, and data lag behind. This evidence gap allows open-loop prediction scores to be overinterpreted as evidence of intervention response or closed-loop reliability beyond what a benchmark directly tests. We identify priorities for evaluating functional utility across downstream roles, developing intervention-based and closed-loop protocols, combining prediction-level and downstream outcome metrics, constructing multimodal action-grounded data, and building standardized and reproducible evaluation toolkits. By clarifying what each benchmark measures and which claims its evidence can support, this survey provides a roadmap toward credible and comparable world-model evaluation. The survey website is available at https://world-model-benchmarks.github.io/.

Article
Engineering
Control and Systems Engineering

Jian Sun

,

Juhao Zhang

Abstract: As the penetration of distributed generation (DG) in distribution networks continues to grow, fault currents shift from a conventional unidirectional flow to bidirectional flow, and the accuracy and adaptability of existing fault location methods are severely challenged when feeder terminal units (FTUs) are subject to false alarms and missed detections. To cope with high DG penetration and FTU information uncertainty, this paper proposes a topology-constrained adaptive binary Archimedes optimization algorithm (TCAB-AOA). Fault location is modeled as a discrete combinatorial optimization problem: an expected fault current function accounting for current direction and information uncertainty is constructed; a hybrid hard-intersection–soft-voting strategy exploits network topology and FTU measurements to compress the search space; differential evolution (DE) and Lévy flight are fused as dual perturbation mechanisms to improve convergence stability; and a greedy cleanup step eliminates residual spurious fault sections. Simulations on the IEEE 33-node system under seven DG-integrated fault scenarios show that TCAB-AOA attains an average location accuracy of 90.0% (47.1 percentage points above the standard Archimedes optimization algorithm) and reduces the average number of misjudged sections to 0.20; in the multi-fault false-alarm scenario, it ranks ahead of particle swarm optimization (PSO), genetic algorithm (GA), and DE.

Article
Engineering
Mechanical Engineering

Magdalena Piasecka

,

Artur Piasecki

Abstract: Infrared thermography provides non-contact access to spatially resolved wall-temperature information, but large flow-boiling archives require traceable separation of physically meaningful variations from measurement artefacts. This study develops a physics-guided workflow for quality assessment of longitudinal infrared temperature profiles extracted from the central line of an externally observed heated foil in rectangular minichannels. The frozen dataset comprised 143,821 complete profiles, 35,666,447 spatial points, 447 source files, and 20 grid families. Leakage-safe source-file-level partitioning was used. Controlled evaluation covered eight local synthetic anomaly morphologies at three intensities and a separate global-offset challenge. A Random Forest using 64 engineered profile descriptors was compared with a five-channel masked residual one-dimensional convolutional neural network operating directly on complete profiles. On the locked test set, the Random Forest achieved an area under the precision-recall curve of 0.915, sensitivity of 0.731, and false-positive rate of 0.082, compared with 0.871, 0.452, and 0.063 for the neural model. Both models deteriorated under external grid-family transfer and remained near chance for uniform temperature offsets. The Random Forest is retained as the preferred supervised benchmark; geometry and grid-family transfer remain the principal unresolved limitation.

Article
Medicine and Pharmacology
Clinical Medicine

Samuel Juliano Lemos Rancatti

,

Adriana Maria Bigliardi

Abstract: Dissociative Identity Disorder (DID), formerly known as multiple personality disorder, is recognized as one of the most complex conditions in the fields of psychiatry and psychology. Initially associated with interpretations of demonic possession, it later came to be understood from a clinical perspective through the contributions of scholars such as Rush, Charcot, and Janet, who emphasized its dissociative nature. The former diagnostic category of hysteria was subsequently reorganized within modern psychiatric classification systems while preserving its underlying conceptual framework. Furthermore, widely publicized cases, such as The Three Faces of Eve and Sybil, contributed to strengthening the association between DID and early-life trauma. It is estimated that 1.5% of the Brazilian population is affected by DID. Between 2018 and 2023, Brazil's Ministry of Health recorded 3,667 cases. This study was conducted as a narrative, descriptive, and exploratory literature review, drawing on databases including Google Scholar, SciELO, and PePSIC, as well as scientific publications, using specific search descriptors related to dissociation and Dissociative Identity Disorder.

Article
Biology and Life Sciences
Animal Science, Veterinary Science and Zoology

Ana Gina Armas

,

Loredana Vaduva

,

Nicusor Marius Maritescu

,

Ioan Petroman

Abstract: Background: Public policies are increasingly judged not only by their support for production but by how they shape trade structure, value distribution and resilience to shocks. Romania's sheep sector has expanded since EU accession, yet whether this has translated into higher-value exports or more resilient trade destinations remains unclear. Methods: Using UN Comtrade, FAOSTAT and Eurostat data for 2003–2024, four dimensions — production base, trade orientation, value structure and geographical concentration — were examined via descriptive indicators, Kendall trend tests, permutation Kruskal–Wallis comparisons across five policy periods, and one-sided sign and Wilcoxon tests, with robustness checks in constant prices. Results: The sheep population grew 42.8% (2003–2024), but slaughter and meat production did not follow proportionally, and the Slaughter Rate fell from 83.6% to 51.1%. Live Export Value Share exceeded 50% every year (median 92.2%), and live export value exceeded meat export value in all 22 years (median ratio 11.8). Eight of fourteen indicators differed significantly across policy periods, and geographical concentration was confirmed for meat but not live-animal exports. Conclusions: The sector combines an expanding productive base with a persistently live-animal-centric export structure; policy should complement production support with investment in slaughter and processing capacity, quality classification and market diversification, rather than restricting live exports.

Review
Biology and Life Sciences
Neuroscience and Neurology

Mohamed Tawfik

Abstract: The retinal neurovascular unit (NVU) emerges through an ordered but overlapping sequence of endothelial growth, lumen formation, perfusion, selective branch retention and acquisition of inner blood-retinal barrier (iBRB) identity. This narrative review synthesizes primary developmental evidence across mouse, human fetal and non-human-primate retina, with emphasis on the experimental readout supported by each model. Mouse superficial angiogenesis advances postnatally across a broad astrocytic field before deep and intermediate plexuses form. Human central assembly instead includes resident vascular precursors before patent vessels, followed by predominantly angiogenic peripheral and intraretinal expansion; comparative primate anatomy adds a superficial-intermediate-deep laminar sequence and persistent foveal vascular exclusion. Across these systems, RGC-astrocyte-matrix interactions establish the superficial growth environment; dynamic endothelial competition, metabolism, lumenization and flow convert sprouts into a remodelled circulation; layer-specific neuronal, Müller-glial and microglial programmes shape intraretinal invasion; and Norrin/FZD4/β-catenin signalling, transcytosis suppression, mural support and vascular zonation establish barrier competence. The evidence also shows that vessel growth, perfusion and barrier function can be uncoupled, which limits inference from oxygen-induced retinopathy and engineered retinal models. Major gaps remain in the lineage of early human vascular precursors, the gestational timing of functional human iBRB maturation, foveal vascular exclusion and integration of layer-specific neuroglial signals.

Review
Engineering
Automotive Engineering

Krisztián Horváth

Abstract: Gearbox noise, vibration, and harshness (NVH) simulation has progressed substantially beyond nominal transmission-error prediction. Contemporary approaches can incorporate manufacturing and assembly tolerances, measured tooth geometry, flexible gear-shaft-bearing-housing interactions, variable-speed operation, acoustic radiation, surrogate modeling, psychoacoustic metrics, and physical-virtual model updating. In parallel, industrial gear production is moving toward near-100% tooth inspection, order-based waviness analysis, process monitoring, virtual end-of-line (EOL) assessment, and manufacturing feedback. Consequently, many capabilities frequently described as future directions already exist individually. This critical review therefore addresses a different question: how strongly are increasingly integrated production-NVH architectures supported by physical evidence? A targeted evidence set of 46 external scientific, doctoral, industrial, and patent sources was classified using a two-dimensional Architecture x Evidence framework. Architectural integration ranges from nominal simulation to unit-specific NVH digital twins and closed-loop manufacturing, whereas evidence maturity ranges independently from conceptual disclosure to component validation, same-unit production validation, population-level validation, and intervention validation. Thirteen of the 46 coded sources reached highly integrated architecture levels A4-A5, yet none reached the E3-E5 range under the adopted criteria. Four traceability requirements are identified for credible production-oriented NVH digital twins: part, physical, spectral, and statistical traceability. Major open problems include propagation of measured joint production distributions, separation of excitation and transfer-path variability, NVH-preserving reduction of high-density tooth metrology, physics-preserving order-map surrogates, quality-control validation of virtual EOL systems, and controlled demonstration that model-selected manufacturing interventions reduce measured acoustic risk. The next generation of gearbox NVH simulation is therefore expected to be defined less by increasing the numerical complexity of an ideal virtual gearbox and more by strengthening the evidence connecting virtual predictions with real manufactured units and production populations.

Review
Public Health and Healthcare
Health Policy and Services

Richard Don Tustin

Abstract: Background. Research shows that children in court-involved families receive low levels of therapy, which might be associated with restrictions on publication of effective therapies. Method. The article reviews mechanisms used to ensure ethical practices are used both when developing innovative mental health interventions and when publishing innovations. Research is regulated as prior approval is required before a proposal is implement, while therapy is monitored as complains can be made after therapy is provided. Three guidelines for developing innovative therapies are reviewed: the combined scientist-practitioner and levels-of-evidence models; the practice of registering health practitioners; and monitoring of assessment and treatment reports by family-oriented courts. The COPE guidelines were developed to help publishers ensure that only human research based on ethical approaches is published. Result. The article notes confusion will result if the COPE regulatory guidelines for research are extended to publication of innovative therapies. Conclusion. The article proposes that publishers accept responsibility for monitoring ethicality when publishing innovative single case studies involving mental health therapy and recognise established mechanisms to ensure ethicality. Use of a standardised consent form is proposed.

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