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Ion-Specific Gelation and Internal Dynamics of Nanocellulose Biocompatible Hybrid Hydrogels: Insights from Fluctuation Analysis
Arianna Bartolomei,
Elvira D'Amato,
Marina Scarpa,
Greta Bergamaschi,
Alessandro Gori,
Paolo Bettotti
Posted: 14 February 2025
Research of the Process of Obtaining Monocalcium Phosphate from Unconditional Phosphate Raw Materials
Abibulla Anarbayev,
Balzhan Kabylbekova,
Zhakhongir Khussanov,
Bakyt Smailov,
Nurlan Anarbaev,
Yevgeniy Kulikov
Posted: 13 February 2025
The Transcription Machinery Driving Force: Why Did Nature Choose Phosphates?
Raúl Riera Aroche,
Esli C. Sánchez Moreno,
Yveth M. Ortiz García,
Andrea C. Machado Sulbarán,
Lizbeth Riera Leal,
Luis R. Olivas Román,
Annie Riera Leal
The dynamic phosphorylation of the human RNA Pol II CTD establishes a code applicable to all eukaryotic transcription processes. However, the ability of these specific post-translational modifications to convey molecular signals through structural changes remains unclear. We previously explained that each gene can be modeled as a combination of n circuits connected in parallel. RNA Pol II accesses these circuits and, through a series of pulses, matches the resonance frequency of the DNA qubits, enabling it to extract genetic information and quantum teleport it. Negatively charged phosphates react under RNA Pol II catalysis, increasing the electron density on the deoxyribose acceptor carbon. The first pulse of phosphorylation connects tyrosine to the nitrogenous base, while the subsequent pulses link the protein to molecular water through hydrogen bonds. The coupling of hydrogen proton transfer with electron transfer in water generates a supercurrent, which is explained by the correlation of pairs of the same type of fermions exchanging a boson. All these changes lead to the formation of a molecular protein-DNA-water condensate.
The dynamic phosphorylation of the human RNA Pol II CTD establishes a code applicable to all eukaryotic transcription processes. However, the ability of these specific post-translational modifications to convey molecular signals through structural changes remains unclear. We previously explained that each gene can be modeled as a combination of n circuits connected in parallel. RNA Pol II accesses these circuits and, through a series of pulses, matches the resonance frequency of the DNA qubits, enabling it to extract genetic information and quantum teleport it. Negatively charged phosphates react under RNA Pol II catalysis, increasing the electron density on the deoxyribose acceptor carbon. The first pulse of phosphorylation connects tyrosine to the nitrogenous base, while the subsequent pulses link the protein to molecular water through hydrogen bonds. The coupling of hydrogen proton transfer with electron transfer in water generates a supercurrent, which is explained by the correlation of pairs of the same type of fermions exchanging a boson. All these changes lead to the formation of a molecular protein-DNA-water condensate.
Posted: 13 February 2025
Producing Aerogels from Rice Straw Cellulose Obtained by a Green Method and Its Starch Blending
Pedro A. V. Freitas,
Paula Alonso Collado,
Chelo González-Martínez,
Amparo Chiralt
Posted: 13 February 2025
Adsorption of Acetic Acid Vapours by Inorganic-Organic Nanomaterials. Implications for the Inhibition of the “Vinegar Syndrome” in 20th-Century Motion Picture Films
Francesca Porpora,
Lorenzo Lisi,
Emiliano Carretti,
Carlotta D'Aleo,
Marianna De Sanctis,
Samuele Baldini,
Luigi Dei
Posted: 13 February 2025
Production, Optimization and Validation Of Fig Gum Products for Extended Shelf-Life
Kenneth Amanze
Posted: 13 February 2025
Catalytic Conversion of Sugars from Coffee Waste and Xylose into Furfural over Fe/SiO2 Catalysts
Kevin René Suárez,
William Giovanni Cortés-Ortiz,
Carlos Alberto Guerrero-Fajardo
Solid Fe catalysts supported on SiO2 with Lewis and Brönsted acidity were synthesized using the sol-gel methodology. FTIR spectroscopy, XRD, Raman spectroscopy, BET isotherms, and SEM characterized the materials. Subsequently, they were used to dehydrate xylose to obtain furfural. It was observed that increasing the metal loading from 0.5 % to 1.5 % by mass increases the selectivity to furfural up to 40.09 %; in addition to this, it was observed that the calcination temperature has an effect concerning the conversion since the materials calcined at 450 °C present higher xylose conversion concerning the materials calcined at 750 °C. Finally, it was observed that the catalysts are active and effective in obtaining furfural from hydrolysates obtained from hydrothermal treatments of the residual biomass of the coffee crop, obtaining an average of 9.11 mg/g of furfural per gram of biomass.
Solid Fe catalysts supported on SiO2 with Lewis and Brönsted acidity were synthesized using the sol-gel methodology. FTIR spectroscopy, XRD, Raman spectroscopy, BET isotherms, and SEM characterized the materials. Subsequently, they were used to dehydrate xylose to obtain furfural. It was observed that increasing the metal loading from 0.5 % to 1.5 % by mass increases the selectivity to furfural up to 40.09 %; in addition to this, it was observed that the calcination temperature has an effect concerning the conversion since the materials calcined at 450 °C present higher xylose conversion concerning the materials calcined at 750 °C. Finally, it was observed that the catalysts are active and effective in obtaining furfural from hydrolysates obtained from hydrothermal treatments of the residual biomass of the coffee crop, obtaining an average of 9.11 mg/g of furfural per gram of biomass.
Posted: 13 February 2025
Effectiveness of Nickel-Titanium Files for Retreatment of Molars Filled with Single-Cone Hydraulic Technique Using Bioceramic Sealers: An In Vitro Study
Jane Lee,
Hyeon-Cheol Kim,
Timothy Kirkpatrick,
David E Jaramillo,
Sang Won Kwak,
Ji Wook Jeong
Posted: 13 February 2025
Critical Perspective on Invalidation-Responsive Materials for Safe Lithium Ion Batteries
Hang-Yu Zhou,
Jian-Hong He,
Shang Gao,
Xuan Cao,
Cheng-Hui Li,
Qing Zhang,
Jia-Liang Gao,
Yong-Zheng Yao,
Chuan-Wei Zhai,
Zhong-Chun Hu
Posted: 13 February 2025
Influence of Printing Orientation on Flexural Strength and Flexural Modulus of Restorative Composites Produced by 3D Printing
Ageu Raupp Junior,
Vagner Ortega,
Marcus Vinícius Reis Só,
Ricardo Abreu da Rosa,
Jéssica Nespolo Martins,
Joatan Lucas de Sousa Gomes Costa,
Weber Addad Ricci,
Mariana Bena Gelio,
Milton Carlos Kuga,
Hugo Alberto Vidotti
Posted: 13 February 2025
Recent Developments of Advanced Broadband Photodetectors Based on 2D Materials
Yan Tian,
Hao Liu,
Jing Li,
Fei Liu,
Baodan Liu
Posted: 12 February 2025
The Promise of Lead-free Perovskites: Can They Replace Toxic Alternatives in Solar Cells and Lead the Future?
Dilshod Nematov,
Iskandar Raufov,
Anushervon Ashurov,
Sakhidod Sattorzoda,
Tehron Najmiddinov,
Saidjon Nazriddinzoda,
Mufazala Umarzoda,
Khonumgul Yusupova
Posted: 12 February 2025
Complex Networks in Phase-Separating Gels. A Computer Simulation Study
Georg Friedrich Beer
Posted: 12 February 2025
Greener Pectin Extraction Techniques: Applications and Challenges
SK Manirul Haque,
Abuzar Kabir,
Elaref Ratemi,
Mohamed Elzagheid,
Sreekumar PA,
Syed Sauban Ghani,
Abdullah Sarief
Posted: 12 February 2025
Ca-, Li-, and Cu-salicylatoborates for applications in Neutron Capture Therapy
Domenica Marabello,
Paola Benzi,
Carlo Canepa,
Alma Cioci
Posted: 12 February 2025
The Bioinorganic Chemistry of the First Row d-Block Metal Ions – An Introduction
Helder M Marques
Posted: 12 February 2025
Green Synthesis, Characterization, and Biological Activity of 4-Aminoquinoline Derivatives: Exploring Antibacterial Efficacy, MRSA Inhibition, and PBP2a Docking Insights
Lo’ay Ahmed Al-Momani,
Ula A. Abu Shawar,
Ayman H. Abu Sarhan,
Rand Shahin,
Panayiotis A. Koutentis,
Mohammad K. Abu-Sini,
Nada J. Mohammad
4-Aminoquinoline derivatives were synthesized on a small scale using a novel microwave-assisted method, and scaled up in sealed tubes. The synthesis adhered to green chemistry principles, employing a solvent-free approach for both the reaction and purification. The purification was achieved through simple washing, no need for column chromatography. All reactions were conducted at temperatures between 90–150 ºC within 90–120 minutes, achieving yields of up to 95%. The products were characterized using FT-IR, 1H- and 13C-NMR spectroscopy, and HR-MS spectrometry. Antibacterial and antifungal activity testing revealed that four compounds exhibited moderate antibacterial activity. Compound 6-chlorocyclopentaquinolinamine demonstrated a strong MIC of 0.125 mM against MRSA, while compound 2-fluorocycloheptaquinolinamine showed a MIC of 0.25 mM against S. pyogenes. A Structure-Activity Relationship (SAR) docking study was conducted within the Penicillin Binding Protein (PBP) binding site. Docking analysis of anti-MRSA com-pounds 7-chlorophenylquinolinamine, 6-chlorocyclopentaquinolinamine, and 2-fluorocycloheptaquinolinamine in the MRSA PBP2a binding pocket (PDB: 4DK1) revealed that 6-chlorocyclopentaquinolinamine and 7-chlorophenylquinolinamine interacted via hydrophobic (ALA601, ILE614), hydrogen bonding (GLN521), and halogen interactions (TYR519, THR399). Compound 6-chlorocyclopentaquinolinamine exhibited superior MRSA inhibition (20 mm inhibition zone vs. 12.5 mm for 7-chlorophenylquinolinamine), attributed to additional π-alkyl interactions and favorable docking parameters, including higher Ligscore2 (4.03), PLP1 (59.15), and Dock Score (34.31). In contrast, compound 2-fluorocycloheptaquinolinamine exhibited weaker activity due to its bulky structure, limited interactions, and less favorable docking scores.
4-Aminoquinoline derivatives were synthesized on a small scale using a novel microwave-assisted method, and scaled up in sealed tubes. The synthesis adhered to green chemistry principles, employing a solvent-free approach for both the reaction and purification. The purification was achieved through simple washing, no need for column chromatography. All reactions were conducted at temperatures between 90–150 ºC within 90–120 minutes, achieving yields of up to 95%. The products were characterized using FT-IR, 1H- and 13C-NMR spectroscopy, and HR-MS spectrometry. Antibacterial and antifungal activity testing revealed that four compounds exhibited moderate antibacterial activity. Compound 6-chlorocyclopentaquinolinamine demonstrated a strong MIC of 0.125 mM against MRSA, while compound 2-fluorocycloheptaquinolinamine showed a MIC of 0.25 mM against S. pyogenes. A Structure-Activity Relationship (SAR) docking study was conducted within the Penicillin Binding Protein (PBP) binding site. Docking analysis of anti-MRSA com-pounds 7-chlorophenylquinolinamine, 6-chlorocyclopentaquinolinamine, and 2-fluorocycloheptaquinolinamine in the MRSA PBP2a binding pocket (PDB: 4DK1) revealed that 6-chlorocyclopentaquinolinamine and 7-chlorophenylquinolinamine interacted via hydrophobic (ALA601, ILE614), hydrogen bonding (GLN521), and halogen interactions (TYR519, THR399). Compound 6-chlorocyclopentaquinolinamine exhibited superior MRSA inhibition (20 mm inhibition zone vs. 12.5 mm for 7-chlorophenylquinolinamine), attributed to additional π-alkyl interactions and favorable docking parameters, including higher Ligscore2 (4.03), PLP1 (59.15), and Dock Score (34.31). In contrast, compound 2-fluorocycloheptaquinolinamine exhibited weaker activity due to its bulky structure, limited interactions, and less favorable docking scores.
Posted: 11 February 2025
Exploring Kink Strengthening in WZ21 Magnesium Alloy via Slow Solidification and Extrusion
Drahomir Dvorsky,
Yoshihito Kawamura,
Shin-Ichi Inoue,
Soya Nishimoto,
Jiri Kubasek,
Anna Boukalová,
Miroslav Čavojský,
Luděk Heller,
Jan Duchoň,
Dalibor Vojtěch
Posted: 11 February 2025
Synergistic Enhancement of Chemiresistive NO₂ Gas Sensors Using Nitrogen-Doped Reduced Graphene Oxide (N-rGO) Decorated with Nickel Oxide (NiO) Nanoparticles: Achieving sub-ppb Detection Limit
Chiheb Walleni,
Mounir Ben Ali,
Mohamed Faouzi Ncib,
Eduard Llobet
Posted: 11 February 2025
Efficient Electro-Catalytic Oxidation Ultra-High Concentration Organic Dye with Ce Doped Titanium-Based Composite Electrode
Chunyang Ni,
Yan Zhao,
Qiao Li,
Zhihui Wang,
Shumei Dou,
Wei Wang,
Feng Zhang
Posted: 10 February 2025
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