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Preprint ARTICLE | doi:10.20944/preprints201610.0065.v1

Views and Preferences for Nicotine Products as an Alternative to Smoking: A Focus Group Study of People Living with Mental Disorders

Carla Meurk, Pauline Ford, Ratika Sharma, Lisa Fitzgerald, Coral Gartner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: nicotine products; tobacco harm reduction; people living with mental illness; qualitative research; consumer preferences

Online: 17 October 2016 (10:49:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0382.v1

A Comparison of Dependence Across Different Types of Nicotine Containing Products and Coffee

Karl Fagerström

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dependence; nicotine; tobacco; coffee

Online: 28 May 2018 (05:16:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0709.v1

COVID-19 Suicide among Adolescents and Youths during the Lockdown: An Exploratory Study based on Media Reports

Md. Dilshad Manzar, Abdulrhman Albougami, Norina Usman, Mohammed A. Mamun

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; lockdown; psychological impacts; self-harm; suicide; COVID-19 suicide; teenage suicide; adolescent suicide; youth suicide; press reporting suicide

Online: 31 August 2020 (05:43:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0619.v1

Prevalence of Stress in Healthcare Professional During COVID-19 Pandemic in Northeast México: A Remote Fast Survey Evaluation, the Use of an Adapted COVID-19 Stress Scale

Juan Luis Delgado-Gallegos, Rene de Jesus Montemayor-Garza, Gerardo R. Padilla-Rivas, Hector Franco-Villareal, Jose Francisco Islas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 Mexico; stress in healthcare professionals; COVID-19 stress scale

Online: 26 September 2020 (08:07:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints201609.0022.v1

Art of Music, as Harmony of the Spheres and Autism Spectrum Disorder

Bharathi Geetha, Thangaraj Sugunadevi, Babu Srija, Nagarajan Laleethambika, Vellingiri Balachandar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Pervasive developmental disorder; Autism spectrum disorder (ASD); brain network; Theory of Mind (ToM); Music Therapy (MT); therapeutic effect

Online: 6 September 2016 (11:53:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0093.v2

Mental Health in Cypriot Citizens of the Rural Health Centre Kofinou

Georgios Stavrou, Eleni Jelastopulu, Lefkios Paikousis, Georgios Charalambous

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; anxiety; emotional distress; HADS; GDS; Health Centre

Online: 11 August 2016 (11:05:44 CEST)

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Objective: The main purpose of this study was to investigate the mental health of Cypriot citizens, living in the current difficult period of economic recession. Specific objective was to investigate the different factors (gender, age, socio-economic factors, etc.) that may affect the levels of emotional distress, anxiety and depression in visitors of the Rural Health Centre of Kofinou. Materials and Methods: The sample consisted of total 300 Cypriots who visited Kofinou Health Centre in the period between August and September 2015. For the middle-aged citizens the Greek version of the HADS scale (Hospital Anxiety Depression Scale) was administered to 150 persons (Michopoulos I., 2007), while for the visiting senior citizens (aged over 65 years) the Greek version of the GDS scale (Geriatric Depression Scale) was used (Fountoulakis K., et al., 1999). All analyses were performed with the social science analysis package SPSS (version 21). Results: HADS: A total of 150 people of average age 47±11,5 years (23-64), were 56% women, while the 77.3% stated they had drastic reduction of income as well as 46.7% suffered from chronic disease. The 36.6% and 28.7% of the visitors showed moderate and severe forms of anxiety and depression, accordingly. Higher emotional distress is associated with lower educational level (p<0,001). Moreover, patients with low income have higher levels of anxiety (p=0,003), depression (p=0,036) and total emotional distress (p=0,007), while those with chronic disease have a higher stress (p<0,001), depression (p<0,001) and total emotional distress symptoms (p<0,001) compared to non - patients. GDS: 150 patients out of which 77 were women (51.3%). The average age of participants was 72±5,5 years. 93(62%) participants declared a drastic reduction of income due to the financial crisis while 139 (92.7%) stated they had chronic disease. 53 participants (35.3%) think they have symptoms of depression after the economic crisis. The women showed higher level of geriatric depression symptoms than men (p<0.001). Higher levels of depression is associated with lower income (p=0.001). Conclusions: The study shows that stress levels, depression and emotional distress are increased in specific population groups. The main factors affecting the mental health of the participants are the presence of chronic disease, income and level of education.

Working Paper REVIEW

A New Perspective of Genetic Associations to the Cause of Multiple Sclerosis: The Role of Genes Expressed on Chromosomes 2 and 5

Robin Terese Montesano

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: multiple sclerosis; MS; cause; genes; polygenic; heredity; autoimmune; diet; depression; fatigue; suicide; seizures; bowel disorders; thyroid; mitochondria; chromosome 2; chromosome 5; glial cells; sunlight; vitamin D3; ultraviolet radiation; melanocyte stimulating hormone; melanocyte concentrating hormone; stress

Online: 22 July 2019 (04:37:27 CEST)

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The literature on the causation of multiple sclerosis (MS), both genetic and environmental, extends over hundreds of years, with no firm conclusions on the exact role of autoimmunity and lifestyle. The epidemiology of MS was the basis for this review, but with a new, extensive examination of genes pertaining to each disorder, and disease of first, and second, degree relatives of those with MS. The author’s motivation was to discover some relationship between MS, and notable familial conditions, as the heredity of MS is concluded to be 30%, and the disorders had a chronic and/or idiopathic nature. This investigation hoped to further understand the randomness of MS- who acquires it, and what symptoms develop- after the author’s decades of observing several incidences of multiple members developing MS in a single family. Online databases for the human genome were used to link genes to MS, and symptoms, including excessive depression, fatigue and suicide rates, in coordination with linking genes for specific familial conditions including seizures, stroke, mental illness, bowel disorders, and thyroid conditions. Interesting associations were found, notably a cluster of Th2 cytokines, known to cure the animal model of MS, important receptors for neurotransmitters and hormones, a gene specific to Epstein Barr Virus, and potential genes for mitochondrial dysfunction. The results surprised the author, showing polygenic regions of chromosome 2 and 5, especially a cluster at loci 5q31-q33, may be dysregulated. The conclusion agrees with past hypotheses MS results not from a single gene, but from various genes, including those expressed in glial cells. The individual theories to the causation of MS, starting with Charcot may be explained by multiple pathways converging into a single disease outcome. In coordination with a sunlight factor, chromosome 2 appears to mediate the immune system, and inflammation, through ultraviolet radiation producing vitamin D3 in the skin, but additionally through peptides formed in the melanocyte stimulating and concentrating hormone class. The impact of stress in MS could be primary, given the loci of several stress-related and stress-modulated genes on these chromosomes, and calls for more appreciation of, and greater care for, the MS patients’ state of mind.

Preprint ARTICLE | doi:10.20944/preprints201901.0249.v1

Can Psychedelics be the Treatment for the Crisis in Psychopharmacology?

Genís Ona, José Carlos Bouso

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health; psychedelics; psychopharmacology; psychiatry; innovative

Online: 24 January 2019 (08:46:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0116.v3

Network Analysis: A Novel Approach to Understand Suicidal Behavior

Derek de Beurs

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; network analysis; symptoms; personalized treatment

Online: 13 February 2017 (11:04:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0346.v2

The Mental Health of School-Going Children During Existing Lockdown Situation Due to COVID-19 Pandemic in Bangladesh

Muhammad Anwar Hossain, Sanjida Rahman, Md Rezaul Karim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health; COVID-19; school-going children; lockdown

Online: 22 July 2020 (07:43:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0047.v2

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Adrenal Axis Dysregulation Model in Stress Induced Genesis of Psychiatric Disorders

Ashutosh Kumar, Pavan Kumar, Muneeb A. Faiq, Vikas Pareek, Khursheed Raza, Sankat Mochan, Pranav Prasoon, Vivek Sharma

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: HPA axis; NGFs; psychiatric disorders; prevention of mental diseases; stress

Online: 4 December 2017 (07:45:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0056.v1

Clinical Decision-Making in the Treatment of Schizophrenia: Focus on Long-Acting Injectable Antipsychotics

Ludovic Samalin, Marion Garnier, Candy Auclair, Pierre-Michel Llorca

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: long-acting injectable; antipsychotic; decision-making; guidelines; schizophrenia

Online: 10 November 2016 (07:00:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0373.v1

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

Laura Fusar-Poli, Vito Cavone, Silvia Tinacci, Ilaria Concas, Antonino Petralia, Maria Salvina Signorelli, Covadonga M. Díaz-Caneja, Eugenio Aguglia

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: autism spectrum disorder; cannabinoids; cannabidiol; cannabidivarin; THC; problem behaviors; sleep; epilepsy; side effects.

Online: 17 July 2020 (09:19:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0106.v1

A Comparative Study of the Causes and Methods of Completed Suicide Referred to Legal Medicine Organization in Bushehr Province, South of Iran, 2006-2015

Alireza Raeisi, Mahmo]od Montazeri, Hiyam Hosseini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: completed suicide; hanging out; self-Immolation; Bushehr; Iran

Online: 24 January 2017 (04:16:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0041.v1

Association between Excessive Use of Mobile Phone and Insomnia and Depression among Japanese Adolescents

Tamura Haruka, Tomoko Nishida, Akiyo Tsuji, Hisataka Sakakibara

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: adolescents; depression; insomnia; mobile phone; Japanese

Online: 7 April 2017 (04:33:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0077.v1

Effects of Forest Therapy on Depressive Symptoms among Adults: A Systematic Review

Insook Lee, Heeseung Choi, Kyung-Sook Bang, Sungjae Kim, MinKyung Song, Buhyun Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: systematic review; forest therapy; depression; adults

Online: 14 March 2017 (08:45:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0078.v1

Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study

Sevdalina Kandilarova, Drozdstoy Stoyanov, Nickolay Sirakov, Michael Maes, Karsten Specht

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depressive disorder, bipolar disorder, structural MRI, grey matter volume, voxel-based morphometry

Online: 8 February 2019 (09:30:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0145.v2

Five Phases Music Therapy (FPMT) in Chinese Medicine: Fundamentals and Application

Hui Zhang, Han Lai

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: emotion and will; music therapy; five phases, five phases music therapy; psychology

Online: 29 November 2017 (09:54:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0124.v1

NegEnt: Cannabidiol-based Aromatherapy - Theoretical Aspects, Pharmacology, Clinical and Research Perspectives, Economic and Social Implications

Tullio Scrimali

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: therapeutic cannabis; cannabidiol; aromatherapy; NegEnt; Herbal Neurocare

Online: 9 June 2020 (13:44:33 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202305.0554.v1

Development and Evaluation of Novel Apomorphine and Quetiapine Combinational Formulation for Parkinson’s Disease in Rat: New Era (Possibilities) for Pre – Clinical Protocol Concept Review

Minesh Patel

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Parkinson’s Disease; Pre-Clinical Protocol; Novel Combinational Formulation; In Vivo Model; In Vivo Study

Online: 9 May 2023 (03:49:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0356.v1

The Psychological Impact of COVID-19 Pandemic among Communities Living in Dilla Town, Ethiopia, April 2020

Chalachew Kassaw

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: anxiety; depression; stress; coronavirus; Dilla; Ethiopia

Online: 30 June 2020 (08:00:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0353.v1

Sleep Disturbances are Consequences or Mediators between Socioeconomic Status and Health: A Scoping Review

Faustin Armel Etindele Sosso, Dimitrios Papadopoulos, Salim R. Surani, Giuseppe Curcio

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sleep disorders; socioeconomic status; mediator; allostatic load; health; scoping review

Online: 29 May 2019 (14:48:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0285.v1

The Neuro-Immune Fingerprint of Major Neuro-Cognitive Psychosis or Deficit Schizophrenia: A Supervised Machine Learning Study

Hussein Al-Hakeim, Abbas Almulla, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Deficit schizophrenia, machine learning, cytokine, cognition, Immunological biomarkers

Online: 23 May 2019 (16:25:44 CEST)

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No studies have examined the immune fingerprint of major neuro-cognitive psychosis (MNP) or deficit schizophrenia using M1 macrophage cytokines in combination with chemokines such as CCL-2 and CCL-11. The present study delineated the neuro-immune fingerprint of MNP/deficit schizophrenia by analyzing plasma levels of IL-1β, sIL-1RA, TNF-α, sTNFR1, sTNFR2, CCL-2 and CCL-11 in MNP (n=120) versus healthy controls (n=54) in association with neurocognitive deficits (as assessed with the Brief Assessment of Cognition in Schizophrenia) and PHEMN (psychotic, hostility, excitation, mannerism and negative) symptoms. All immune biomarkers were significantly higher in MNP than in normal controls. MNP was best predicted by a combination of CCL-11, TNF-α, IL-1β and sIL-1RA which yielded a bootstrapped (n=2000) area under the Receiver Operating Curve of 0.985. Composite scores reflecting M1 macrophage activity and neurotoxic potential including combined effects of CCL-11 plus CCL-2 were significantly increased in MNP. Nevertheless, the effects of increased IL-1β and TNF-α in MNP were attenuated (statistically) by increased sIL-1RA and sTNFR2, two negative immune-regulatory markers. A large part of the variance in PHEM (38.4%-52.6%) and negative (65.8-7439%) symptoms was explained by combinations of immune markers whereby CCL-11 was consistently the most important. The immune markers also explained a large part of the variance in the Mini Mental State examination, list learning, digit sequencing task, category instances, controlled word association, symbol coding and Tower of London. Soft Independent Modeling of Class Analogy performed on the biomarkers showed that the inter-class distance between the models constructed around MNP and controls was 19.3 indicating a good separation. Partial Least Squares analysis showed that 72.7% of the variance in overall phenomenology was explained by the regression on IL-1β, sIL-1RA, CCL-11, TNF-α (all positively) and education (inversely). It is concluded that the combination of the above-mentioned markers defines MNP as a distinct neuro-immune disorder and that those markers in combination explain a large part of the variance in memory and executivive impairments and PHEMN symptoms.

Preprint ARTICLE | doi:10.20944/preprints202011.0381.v1

Perceived Stress, Depression and Alcohol Use Disorders in College Students During the COVID-19 Pandemic: A Socio-Economic Dimension

Beata Gavurova, Viera Ivankova, Martin Rigelsky

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alcohol dependence; Depression; Stress; Gender; Income; Differences; Behavioural disorders; Mental disorders; Socio-economic effects; Pandemic; Isolation; COVID-19; Slovak students

Online: 13 November 2020 (13:24:34 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0641.v1

Influence of Socioeconomic Status and Stress Over Quality of Sleep: A Systematic Review

Faustin Armel Etindele Sosso, Aarti Jagannath, Fabricio Ferreira De Oliveira, Salim R. Surani, Vincent Mysliwiec

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sleep, socioeconomic status, stress, circadian rhythm, allostatic load, mood disorder, social class

Online: 26 October 2018 (16:32:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0029.v1

Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities

Adriano José Maia Chaves Filho, Danielle S. Macedo, David Freitas de Lucena, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depressive disorder, microglia, cytokines, neuro-immune, chronic fatigue, oxidative stress

Online: 4 February 2019 (11:41:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0142.v1

Feasibility of Children in Disaster: Evaluation and Recovery (CIDER) Protocol for Traumatized Adolescents in South Korea: A Preliminary Study

Mi-Sun Lee, Hyun Soo Kim, Eun Jin Park, Soo-Young Bhang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: CIDER; post-traumatic stress disorder; trauma; adolescent; trauma-focused group psychotherapy

Online: 15 February 2019 (15:04:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0227.v1

Differences in the Course of depression and anxiety After COVID-19 Infection Between Recovered Patients With and Without a Psychiatric History: A Cross-Sectional Study

Megumi Hazumi, Kentaro Usuda, Emi Okazaki, Mayumi Kataoka, Daisuke Nishi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; depression; anxiety; post-acute COVID-19 syndrome; post-COVID

Online: 12 August 2022 (04:56:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0033.v1

Major Depression in Children with β-Thalassemia Major is Strongly Associated with the Number of Blood Transfusions, Iron Overload and Increased Levels of Interleukin-1β

Hussein Kadhem Al-Hakeim, Asawer Hassan Najm, Arafat Hussein Al-Aldujaili, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; cytokines; neuro-immune; inflammation; oxidative stress; antioxidants

Online: 3 September 2019 (16:20:18 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202007.0636.v1

Prevalence and Associated Factors of Emotional and Behavioural Difficulties during COVID-19 Pandemic in Children with Neurodevelopmental Disorders

Jacqueline Nonweiler, Fiona Rattray, Jennifer Baulcomb, Francesca Happe, Michael Absoud

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Autism Spectrum Disorder; Attention-deficit/hyperactivity disorder; Behavioural Neuroscience; Mental Health; COVID-19; Pandemic; Paediatric Neurology

Online: 26 July 2020 (15:31:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0146.v1

Acupuncture as Add-On Treatment of the Positive, Negative, and Cognitive Symptoms of Patients with Schizophrenia: A Systematic Review

Maurits Van den Noort, Sujung Yeo, Sabina Lim, Sook-Hyun Lee, Heike Staudte, Peggy Bosch

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; psychosis; sleep; sleep disturbances; sleep disorders; integrative medicine; acupuncture; add-on therapy

Online: 23 February 2018 (04:59:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202002.0084.v1

The Microbiota-gut-immune-glia (MGIG) Axis in Major Depression

Leszek Rudzki, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; leaky gut; microbiota; cytokines; neuroimmunomodulation; oxidative stress

Online: 6 February 2020 (10:30:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0625.v3

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Science in Mood and Anxiety Disorders

Lehel Balogh, Masaru Tanaka, Nóra Török, László Vécsei, Shigeru Taguchi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; anxiety disorders; existential psychotherapy; logotherapy; meaning-centered psychotherapy; functional magnetic resonance imaging; biomarker; kynurenines; Martin Heidegger; Viktor Frankl

Online: 24 March 2021 (13:18:24 CET)

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Preprint REVIEW | doi:10.20944/preprints201804.0233.v1

Network Medicine and Alzheimer’s Disease Therapy

Juliet T. Jarrell, Li Gao, David S. Cohen, Xudong Huang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer’s Disease; network medicine; inflammation; network and system pharmacology; traditional Chinese medicine

Online: 18 April 2018 (07:41:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0131.v1

Ketoprofen as an Add-on Treatment to Sertraline for Drug-Naïve Major Depressed Patients: Normalization of Plasma Levels of Indoleamine-2,3-Dioxygenase in Association with Pro-Inflammatory and Immune Regulatory Cytokines

Hussein Al-Hakeim, Ahmed Jasim Twayej , Arafat Hussein Al-Dujaili , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Major depressive disorder (MDD), ketoprofen, TGF-β1, INF-γ, IDO, immune, inflammation

Online: 11 December 2018 (13:52:50 CET)

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Preprint REVIEW | doi:10.20944/preprints201805.0177.v1

Hippocampal Volume Changes in Patients with Mood Disorders: A Systematic Review of MRI Studies

Marcelo Antônio Oliveira Santos, Lucas Soares Bezerra, Alessandra Mertens Brainer-Lima, Ana Rita Ribeiro Marinho Carvalho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: hippocampus volume; mood Disorders; MRI; depression; subiculum; CA1

Online: 11 May 2018 (06:32:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0176.v1

In Major Depression, Increased Serum Dynorphin and Kappa Opioid Receptor Levels are Positively Associated with Mu Opioid Receptor Levels and Immune Activation and Are Attenuated by Nicotine Dependence

Hussein Al-Hakeim, Suhaer Al-Fadhel, Arafat Hussein Al-Dujaili, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; cytokines; inflammation; endogenous opioid; opioid receptor

Online: 16 April 2019 (09:49:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0306.v1

Mental Health Issues in Madhya Pradesh: Insights from National Mental Health Survey of India 2016.

Arun Kokane, Abhijit Pakhare, Gopalkrishna Gururaj, Mathew Varghese, Vivek Benegal, Girish Rao, Aravind B A, Mukesh Shukla, Arun Mitra, Kriti Yadav, Rajni Chatterji, Sukanya Ray, Akash Ranjan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Mental disorder, treatment gap, health system, Madhya Pradesh.

Online: 30 January 2019 (09:25:43 CET)

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Preprint REVIEW | doi:10.20944/preprints201712.0051.v1

DBS in Treatment of Post-Traumatic Stress Disorder

Angelo Lavano, Giusy Guzzi, Attilio Della Torre, Serena Marianna Lavano, Raffaele Tiriolo, Giorgio Volpentesta

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: posttraumatic stress disorder; deep brain stimulation; fear extinction; amygdala; prefrontal cortex

Online: 8 December 2017 (07:21:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0217.v1

An Overview of Mental Health During the COVID-19 Pandemic

Patrick Chen, Yanna Pusica, Dorsa Sohaei, Ioannis Prassas, Eleftherios Diamandis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; pandemic; mental health; psychological health; anxiety; suicide

Online: 8 March 2021 (13:32:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0194.v1

From Recession to Depression? Prevalence and Correlates of Depression, Anxiety, Traumatic Stress and Burnout in Healthcare Workers During the COVID-19 Pandemic in Greece: A Multi-Center, Cross-Sectional Study

Sofia Pappa, Nikolaos Athanasiou, Nikolaos Sakkas, Stavros Patrinos, Elpitha Sakka, Zafeiria Barmparessou, Stamatoula Tsikrika, Andreas Adraktas, Athanasia Pataka, Ilias Migdalis, Sofia Gida, Paraskevi Katsaounou

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; health care workers; Greece; mental health; depression; anxiety; traumatic stress; burnout

Online: 8 February 2021 (11:41:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0098.v2

Prevalence of Mental Disorders and Addictions among the Homeless Population in the Greater Paris Area, France

Anne Laporte, Stéphanie Vandentorren, Marc-Antoine Détrez, Caroline Douay, Yann Le Strat, Erwan Le Mener, Pierre Chauvin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: homeless; mental health; epidemiology; psychotic disorders; anxiety; mood disorders; alcohol

Online: 16 January 2018 (13:12:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0207.v1

The Prevalence and Sociodemographic Correlates of Social phobia in Oman: Online National Survey

Aamal Ambusaidi, Salim Al Huseini, Hiba Alshaqsi, Manal AlGhafri, Moon-Fai Chan, Nasser Al-Sibani, Samir Al-Adawi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Social Anxiety Disorder; Social Phobia, Online Survey; Adult, Oman; Liebowitz Social Anxiety Scale

Online: 8 August 2020 (09:39:49 CEST)

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Working Paper ARTICLE

‘An Apple A Day’?: Psychiatrists, Psychologists and Psychotherapists Report Poor Literacy for Nutritional Medicine: International Survey Spanning 52 Countries

Sabrina Mörkl, Linda Stell, Diana V Buhai, Melanie Schweinzer, Jolana Wagner-Skacel, Christian Vajda, Sonja Lackner, Susanne A Bengesser, Theresa Lahousen-Luxenberger, Annamaria Painold, Andreas Oberascher, Josef M Tatschl, Matthäus Fellinger, Annabel Mueller-Stierlin, Ana C Serban, Joseph Ben-Sheetrit, Ana-Marija Vejnovic, Mary I Butler, Vicent Balanza-Martinez, Nikola Zaja, Polona Rus-Prelog, Robertas Strumila, Scott B Teasdale, Eva Z Reininghaus, Sandra J Holasek

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Nutritional Psychiatry; Mental Health Professionals; Psychiatrists; Psychologists; Psychotherapists; Education; Psychiatric Disorders; Diet; Supplements; Nutrition

Online: 16 February 2021 (13:36:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0091.v1

Tired, Worried and Burned Out But Still Resilient: A Cross-Sectional Study of Mental Health Workers During the Covid-19 Pandemic

Sofia Pappa, Joshua Barnett, Ines Berges, Nikolaos Sakkas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; healthcare workers; United Kingdom; mental health; burnout; resilience; insomnia; depression; anxiety; lifestyle

Online: 5 April 2021 (10:24:40 CEST)

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The burden of COVID-19 pandemic on health systems and the physical and mental health of healthcare workers (HCWs) has been substantial. This cross-sectional study aims to assess the effects of Covid-19 on the psychological wellbeing of mental health workers who provide care to a vulnerable patient population that have been particularly affected during this crisis. A total of 387 HCWs from across a large urban mental health service completed a self-administered questionnaire consisting of socio-demographic, lifestyle and work-based information and validated psychometric scales. Depression and anxiety were measured using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Scale (GAD-7) respectively, sleep problems with the Athens Insomnia Scale (AIS), burnout with the Maslach Burnout Inventory (MBI) and resilience with the Resilience Scale-14 (RS-14). Multivariable logistic regression analysis was performed to determine potential mediating factors. Prevalence of burnout was notable, with 52% recording moderate/severe in Emotional Exhaustion, 19.5% moderate/severe in Depersonalisation and 55.5% low/moderate Personal Accomplishment. Over half of all respondents (52%) experienced sleep problems; the presence of depressive symptoms was a significant predictor of insomnia. An increase in potentially harmful lifestyle changes, such as smoking, alcohol consumption and over-eating was also observed. However, high Resilience was reported by 70% of the sample and the importance of this is highlighted. Female gender was associated with increased levels of depression and emotional exhaustion while those with a history of mental health conditions were most at risk of affective symptoms, insomnia and burnout. Overall, our study revealed considerable levels of psychological distress and maladaptive coping strategies but also resilience and satisfaction with organizational support provided. Findings can inform tailored interventions in order to mitigate vulnerability and prevent long-term psychological sequelae.

Preprint REVIEW | doi:10.20944/preprints202009.0417.v1

Neglect of Legal Statute Influence on Health Outcomes in Studies about Human Cannabis Use

Thiago Moulin, José Airton Alves, João Menezes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; stress; drug policy; environment; contaminants; pesticides; fungi; prohibition

Online: 18 September 2020 (04:21:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0138.v1

The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors are Associated with Interleukin-6

Shatha Rouf Moustafa, Khalid F. Al-Rawi, Arafat Hussein Al-Dujaili, Thitiporn Supasitthumrong, Hussein Kadhem Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; Schizophrenia; treatment resistance; neurocognition; neuroimmunomodulation

Online: 13 January 2020 (04:15:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0095.v1

In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota

Andressa Keiko Matsumoto, Michael Maes, Annabel Maes, Ana Paula Michelin , Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania Moreira, Buranee Kanchanatawan, Decio S. Barbosa

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia; antioxidants; bacteria; neuro-immune; inflammation; oxidative and nitrosative stress

Online: 9 September 2019 (09:00:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0232.v1

The Neurobiology of Autism Spectrum Disorder As It Relates to Twice Exceptionality

Rachel Sharkey, Thomas Nickl-Jockschat

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: twice exceptionality; autism spectrum disorder; neuroimaging; MRI

Online: 15 October 2021 (16:17:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0345.v1

Alzheimer's in Post-Industrial Epoch

Alexander Kholmanskiy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mortality; Alzheimer's; education; life expectancy; mentality; level of development

Online: 29 May 2019 (08:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0182.v1

Breakdown of the Paracellular Tight and Adherens Junctions in the Gut and Blood Brain Barrier and Damage to the Vascular Barrier in Patients with Deficit Schizophrenia

Michael Maes, Sunee Sirivichayakul, Buranee Kanchanatawan, Aristo Vojdani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; inflammation; neuro-immune; oxidative stress; TRYCATs; leaky gut

Online: 19 February 2019 (12:14:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201711.0061.v1

Salivary Oxytocin Concentration Changes during a Group Drumming Intervention for Maltreated School Children

Teruko Yuhi, Hiroaki Kyuta, Hisa-aki Mori, Chihiro Murakami, Kazumi Furuhara, Mari Okuno, Masaki Takahashi, Daikei Fuji, Haruhiro Higashida

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: child abuse; maltreatment; intervention; drum playing; salivary; oxytocin

Online: 9 November 2017 (08:43:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0212.v2

Stigma and Discrimination on People Living with HIV (PLHIV): a Systematic Review

Khotibul Umam, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Stigma, discrimination, HIV/AIDS

Online: 19 April 2021 (22:13:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0206.v1

An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry

Jose Jaime Martínez-Magaña, Thelma Beatriz Gonzalez-Castro, Alma Delia Genis-Mendoza, Carlos Alfonso Tovilla-Zarate, Isela Juarez-Rojop, Erasmo Saucedo-Uribe, Nuria Lanzagorta, Michael Escamilla, Luis Macías-Kauffer, Humberto Nicolini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Mexican Amerindian, Dual diagnosis, polygenic risk scores, psychiatric diseases, bipolar disorder, schizophrenia, substance use disorder

Online: 12 September 2018 (01:20:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0141.v1

Upregulation of the Intestinal Paracellular Pathway with Breakdown of Tight and Adherens Junctions in Deficit Schizophrenia

Michael Maes, Sunee Sirivichayakul, Buranee Kanchanatawan, Aristo Vodjani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; leaky gut; neuro-immune; inflammation; oxidative stress; TRYCATs; cytokines

Online: 15 January 2019 (07:17:55 CET)

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In 2001, the first author of this paper reported that schizophrenia is associated with an increased frequency of the haptoglobin (Hp)-2 gene. The precursor of Hp-2 is zonulin, a molecule that affects intercellular tight junction integrity. Recently, we reported increased plasma IgA/IgM responses to Gram-negative bacteria in deficit schizophrenia indicating leaky gut and gut dysbiosis. The current study was performed to examine the integrity of the paracellular (tight and adherens junctions) and transcellular (cytoskeletal proteins) pathways in deficit versus non-deficit schizophrenia. We measured IgM responses to zonulin, occludin, E-cadherin, talin, actin and vinculin in association with IgA responses to Gram-negative bacteria, CCL-11, IgA responses to tryptophan catabolites (TRYCATs), immune activation and IgM to malondialdehyde (MDA) and NO-cysteinyl in 78 schizophrenia patients and 40 controls. We found that the ratio of IgM to zonulin + occudin / talin + actin + viculin (PARA/TRANS) was significantly greater in deficit than in non-deficit schizophrenia and higher in schizophrenia than controls and was significantly associated with increased IgA responses to Gram-negative bacteria. IgM responses to zonulin were positively associated with schizophrenia (versus controls), while IgM to occludin was significantly associated with deficit schizophrenia (versus non-deficit schizophrenia and controls). A large part of the variance (90.8%) in negative and PHEM (psychosis, hostility, excitation and mannerism) symptoms was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, IgM to E-cadherin and malondialdehyde (MDA) and memory dysfunctions, while 53.3% of the variance in the latter was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, CCL-11, TRYCATs and immune activation. The results show an upregulated paracellular pathway with breakdown of the tight and ahherens junctions and increased bacterial translocation in deficit schizophrenia. These dysfunctions in the intestinal paracellular route together with lowered natural IgM, immune activation and production of CCL-11 and TRYCATs contribute to the phenomenology of deficit schizophrenia.

Working Paper ARTICLE

Pulse Wave Harmony: Ancient Wisdoms for Modern Age

Patrick Celka, Lobsang Samten, Marina Brucet, Abdullah Alabdulgader

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: pulse wave analysis; mental stress; harmonic analysis; Eastern pulse reading

Online: 10 September 2019 (05:19:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0149.v1

The Relationships between Smartphone Addiction of Middle School Students and Smartphone Usage Types, Depression, ADHD, Stress, Interpersonal Problems, and Parenting Attitude

Youl Pyo Hong, Yeon Ok Yeom, Myung Ho Lim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Smartphone Addiction; Middle School Students; Smartphone Usage Types; Depression; Parenting Attitude

Online: 6 September 2020 (16:27:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0314.v1

Activation of the Immune-Inflammatory Response System and the Compensatory Immune-Regulatory Reflex System in Antipsychotic Naive First Episode Psychosis

Mariane Nunes Noto, Michael Maes, Sandra Odebrecht Vargas Nunes, Vanessa Kiyomi Ota, Ana C. Rossaneis, Waldiceu A. Verri Jr., Quirino Cordeiro, Sintia Iole Belangero, Ary Gadelha, Rodrigo Affonseca Bressan, Cristiano Noto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; first episode psychosis; antipsychotic; immune; inflammation; cytokines

Online: 17 September 2018 (14:13:38 CEST)

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Background: First episode psychosis (FEP), schizophrenia and affective disorders are accompanied by activation of the immune inflammatory response system (IRS). The compensatory immune-regulatory reflex system (CIRS) is a regulatory immune response that is induced by the IRS but exerts negative feedback through, for example, increased levels of anti-inflammatory cytokines such as IL-4, IL-13 and IL-10. Different phenotypes of schizophrenia may exhibit distinct IRS and CIRS immune profiles.Aims: This study aims to examine the IRS and CIRS components, including macrophagic M1, T-helper (Th)-1, Th-2, Th-17 and T-regulatory (Treg) phenotypes, in antipsychotic-naïve FEP patients before and after risperidone treatment.Methods: We included 31 antipsychotic-naïve FEP patients who had measurements of IRS and CIRS biomarkers before and after treatment with risperidone for 10 weeks, and 22 healthy controls.Results: Antipsychotic-naive FEP patients showed interrelated increments in M1, Th-1, Th-2, Th-17 and Treg phenotypes and a relatively greater IRS response (especially granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-12) as compared with the CIRS response (IL-4, IL-13, IL-5 and IL-10). Inflammatory markers, especially IL-6 and IL-8, were significantly correlated with negative, psychotic, affective and excitation symptom dimensions. Treatment with risperidone significantly suppressed the IRS and CIRS. Baseline levels of CIRS biomarkers, especially higher soluble tumor necrosis factor receptor-1 and IL-10 predicted clinical improvement during treatment.Discussion: Our findings indicate that FEP is characterized by robust IRS (M1 + Th-1 + Th-17) and CIRS responses, suggesting that monocytes, macrophages, Th-1, Th-2, Th-17 and Treg cells are activated. The findings indicate that a) FEP patients are prone to the detrimental effects of M1, Th-1, Th-17 and Th-2 cells, which may contribute to long-lasting abnormalities in brain circuitry; and b) in FEP, the CIRS may contribute to recovery from the acute phase of illness. Enhancing the CIRS is a new drug target to treat FEP.

Preprint REVIEW | doi:10.20944/preprints202006.0058.v1

From "Leaky Gut" to Impaired Glia-neuron Communication in Depression

Leszek Rudzki, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; leaky gut; microbiota; cytokines; neuroimmunomodulation; oxidative stress; glia; blood-brain barrier; LPS; TLR

Online: 5 June 2020 (15:06:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0526.v1

Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signaling

Mary Scriven, Mary Wall, John F. Cryan, Timothy G. Dinan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychiatry; gut microbiome; probiotics

Online: 27 July 2018 (03:22:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0134.v1

The Tryptophan Catabolite or Kynurenine Pathway’s Role in Major Depression

Abbas F. Almulla, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: TRYCATs; MDD; MDE; Suicidal behavior; Kynurenine pathway

Online: 11 January 2022 (10:39:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201903.0105.v1

Upregulation of the Nitrosylome in Bipolar Disorder Type 1 (BP1), but not BP2, and Major Depression: Increased IgM Antibodies to Nitrosylated Conjugates are Associated with Indicants of Leaky Gut

Michael Maes, Denitsa Simeonova, Drozdstoy Stoyanov, Jean–Claude Leunis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression, bipolar disorder, oxidative and nitrosative stress, neuro-immune, inflammation, cytokines

Online: 8 March 2019 (09:13:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0135.v1

Lowered Zinc and Copper Levels in Drug-Naïve patients with Major Depression: Effects of Antidepressants, Ketoprofen and Immune Activation

Ahmed Jasim Twayej , Hussein Al-Hakeim, Arafat Hussein Al-Dujaili , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Depression, inflammation, neuro-immune, interleukins, ketoprofen, zinc

Online: 14 January 2019 (11:47:42 CET)

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There is now evidence that major depression is accompanied by lowered serum zinc, an immune-inflammatory biomarker. However, the effect of anti-inflammatory drugs as adjuvant to antidepressants on serum zinc and copper in relation to pro- and anti-inflammatory cytokines are not studied. The aim of the present work is to examine the effects of treatment with sertraline with and without ketoprofen on serum levels of zinc and copper in association with immune-inflammatory biomarkers in drug-naïve major depressed patients. We measured serum zinc and copper, interleukin (IL)-1β, IL-4, IL-6, IL-18, interferon (IFN)-γ, and transforming growth factor (TGF)-β1 in 40 controls and 133 depressed patients. The clinical efficacy of the treatment was measured using the Beck Depression Inventory-II (BDI-II) at baseline and 8 weeks later. In drug-naïve major depressed patients we found significantly reduced baseline levels of serum zinc and copper in association with upregulation of all cytokines, indicating activation of the immune-inflammatory responses system (IRS) as well as the compensatory immune regulatory system (CIRS). Treatment with sertraline significantly increased zinc and decreased copper levels, while ketoprofen did not have a significant add-on effect on zinc but attenuated the suppressant effects of sertraline on copper levels. During treatment, there was a significant inverse association between serum zinc and activation of the IRS/CIRS. The improvement in the BDI-II during treatment was significantly associated with increments in serum zinc coupled with attenuation of the IRS/CIRS. In conclusion, lower serum zinc is a hallmark of depression, while increments in serum zinc and attenuation of the immune-inflammatory response during treatment appear to play a role in the clinical efficacy of sertraline. Intertwined changes in zinc levels and the immune response play a role in the pathophysiology of major depression and participate in the mechanisms underpinning the clinical efficacy of antidepressants.

Preprint ARTICLE | doi:10.20944/preprints202008.0251.v1

Mental Health Assessment Method Based on Emotion Level Derived from Voice

Shuji Shinohara, Mitsuteru Nakamura, Yasuhiro Omiya, Masakazu Higuchi, Naoki Hagiwara, Shunji Mitsuyoshi, Hiroyuki Toda, Taku Saito, Masaaki Tanichi, Aihide Yoshino, Shinichi Tokuno

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health assessment; vitality; mental activity; voice index; emotion analysis; noninvasiveness

Online: 11 August 2020 (05:33:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0062.v1

Sickness Behaviour and Depression: An Updated Model of Peripheral-Central Immunity Interactions

Federico Turkheimer, Mattia Veronese, Valeria Mondelli, Diana Cash, Carmine Pariante

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Major depression; inflammation; sickness behaviour; mechanism; model; microglia; zcitokynes; CRP; blood brain barrier; choroid plexus

Online: 3 March 2022 (10:28:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0236.v1

Total and Ionized Calcium and Magnesium Are Significantly Lowered in Drug-Naïve Depressed Patients: Effects of Antidepressants and Associations with Immune Activation

Arafat Hussein Al-Dujaili , Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; neuro-immune; cytokines; inflammation; indoleamine 2,3-dioxygenase

Online: 26 February 2019 (11:05:49 CET)

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Major depressive disorder (MDD) is associated with changes in the levels of the cations calcium (Ca) and magnesium (Mg) as well as circulating pro- and anti-inflammatory cytokines. The immune-inflammatory nature of MDD has encouraged researchers to use anti-inflammatory drugs as an adjuvant treatment for MDD. However, the effect of this treatment on cation levels has not been studied. The present study examined a) differences in both cations between drug-naïve MDD patients and controls, and b) the effects of a combination of sertraline and ketoprofen, an anti-inflammatory drug, on Ca and Mg (both total and ionized). In the same patients we also examined the associations between both cations and IL-1β, IL-4, IL-6, IL-18, IFN-γ, TGF-β1, zinc and indoleamine 2,3-dioxygenase (IDO). Clinical improvement was estimated using the Beck Depression Inventory-II (BDI-II) at baseline and after follow up for two months. Serum Ca and Mg (total and ionized) were significantly lower in MDD patients as compared with controls, while treatment significantly increased calcium but decreased magnesium levels. There were significant and inverse correlations between the BDI-II scores from baseline to endpoint and Ca (both total and ionized), but not Mg, levels. The effects of calcium on the BDI-II score remained significant after considering the effects of zinc, IDO and an immune activation z unit weighted composite score based on the sum of all cytokines. There was a significant and inverse association between this immune activation index and calcium levels from baseline to endpoint. In conclusion, reduced levels of both cations play a role in the pathophysiology of major depression. Increased calcium levels are coupled to the clinical efficacy of antidepressants and attenuation of immune activation. The suppressant effect of antidepressants on Mg levels may be a side effect of those drugs. New antidepressant treatments should be developed that increase the levels both Ca and Mg.

Preprint ARTICLE | doi:10.20944/preprints201802.0140.v1

The Mental Health Status and Intellectual Ability of Unwed Mothers Dwelling in Korea Shelter Homes

Suyeon Jo, Soowon Park, Jung Hae Youn, Bo Kyung Sohn, Hyo Jung Choi, Ji Yeon Lee, Jin Yong Lee, Jun-Young Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: unwed mother; mental health; intellectual ability

Online: 22 February 2018 (09:03:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0082.v1

Investigating the Gut Microbiota Composition of Individuals with Attention-Deficit/Hyperactivity Disorder and Association with Symptoms

Joanna Szopinska-Tokov, Sarita Dam, Jilly Naaijen, Prokopis Konstanti, Nanda Rommelse, Clara Belzer, Jan Buitelaar, Barbara Franke, Esther Aarts, Alejandro Arias Vasquez

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: gut microbiota; ADHD; 16S rRNA gene; Inattention

Online: 6 February 2020 (10:25:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0083.v1

Psychological Distress among Bangladeshi Dental Students during the COVID-19 Pandemic

Farah Sabrina, Mohammad Tawfique Hossain Chowdhury, Sujan Kanti Nath, Ashik Abdullah Imon, S M Abdul Quader, Md Shahed Jahan, Ashek Elahi Noor, Clopa Pina Podder, Unisha Gainju, Rina Niroula, Muhammad Aziz Rahman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Psychological distress; Fear; Coping; COVID-19; Bangladesh; Dental; Mental health

Online: 6 December 2021 (15:22:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0365.v1

Connecting the Dots Between Mental and Menstrual Health

Esther Ajari

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Menstruation; menstrual health; menstrual hygiene; period poverty; mental health; mental disorder

Online: 17 May 2021 (07:51:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0037.v1

Hygiene Behavior in Face of the Corona Pandemic: Compliance Rates and Associations With Fear, SARS-COV-2 risk, Mental Health and Disability

Sonia Lippke, Franziska M. Keller, Christina Derksen, Lukas Kötting, Alina Dahmen

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; disability; risk factors; communication; medical rehabilitation; psychosomatic patients; general public; infection; physical health; psychological health

Online: 2 September 2021 (12:08:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0201.v1

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB and Wnt/Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis andChronic Fatigue Syndrome: A Review and New Hypothesis Based on Results of Network, Enrichment and Annotation Analyses

Michael Maes, Marta Kubera, Magdalena Kotańska

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; Myalgic Encephalomyelitis; inflammation; neuro-immune; oxidative and nitrosative stress; antioxidants

Online: 13 September 2021 (10:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0423.v1

One-Year Prospective Study of Occupational Health in the Intensivists of a COVID-19 Hub Hospital

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: longitudinal study; emergency; infectious disease; organizational justice; stress; loneliness; compassion fatigue; meditation; prayer; insomnia; mental health; anaesthetists

Online: 23 August 2021 (10:22:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0411.v2

Short but Continuous Natural Pain for Depression Treatment and Beyond

Mingwei Huang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: pain; depression; treatment; meditation; synaptic plasticity and homeostasis; DNA damage response

Online: 31 May 2018 (09:51:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0317.v1

Childhood Trauma and Stressful Life Events Are Independently Associated with Sleep Disturbances in Adolescents

Suman K.R. Baddam, Rene L. Olvera, Craig A. Canapari, Michael J. Crowley, Douglas E. Williamson

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: childhood trauma; stressful life events; sleep patterns; anxiety; depression; adolescence

Online: 27 May 2019 (12:36:54 CEST)

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Working Paper ARTICLE

Interrogating Hope Theory

Jacob Shivley

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: interrogating hope theory, hope theory, hope, the hope scale, positive psychology

Online: 25 March 2019 (09:53:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0004.v1

The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: a Systematic Review and Meta-Analysis

Sarah Houben, Bruno Bonnechère

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Long-COVID; cognitive disorders; rehabilitation

Online: 1 June 2022 (05:50:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0289.v1

The Role of Aberrations in the Immune-inflammatory Reflex System (IRS) and the Compensatory Immune-regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: The IRS-CIRS Theory of Schizophrenia

Chutima Roomruangwong, Cristiano Noto, Buranee Kanchanatawan, George Anderson, Marta Kubera, Andre F. Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia, immune system, inflammation, cytokines, immune regulatory, CIRS, psychiatry, immunology, psychosis

Online: 17 September 2018 (08:57:53 CEST)

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In this paper we propose a novel theoretical framework, which was previously developed for major depression and bipolar disorder, namely the compensatory immune-regulatory reflex system (CIRS), as applied to the neuro-immune pathophysiology of schizophrenia and its phenotypes, including first episode psychosis (FEP), acute relapses, chronic and treatment resistant schizophrenia (TRS), comorbid depression, and deficit schizophrenia. These schizophrenia phenotypes and manifestations are accompanied by increased production of positive acute phase proteins, including haptoglobin and α2-macroglobulin, complement factors, and macrophagic M1 (IL-1β, IL-6 and TNF-α), T helper (Th)-1 (interferon-γ and IL-2R), Th-2 (IL-4, IL-5), Th-17 (IL-17) and T regulatory (Treg; IL-10 and transforming growth factor (TGF)-β1) cytokines, cytokine-induced activation of the tryptophan catabolite (TRYCAT) pathway as well as chemokines, including CCL-11 (eotaxin), CCL-2, CCL-3 and CXCL-8. While the immune profiles in the different schizophrenia phenotypes indicate activation of the immune-inflammatory response system (IRS), there are simultaneous signs of CIRS activation, including increased levels of the IL-1 receptor antagonist (sIL-1RA), sIL-2R and tumor necrosis factor-a receptors, Th-2 and Treg phenotypes with increased IL-4 and IL-10 production, and increased levels of TRYCATs and haptoglobin, α2-macroglobulin and other acute phase reactants, which have immune-regulatory and anti-inflammatory effects. Signs of activated IRS and CIRS pathways are also detected in TRS, chronic and deficit schizophrenia indicating that these conditions are accompanied by a new homeostatic setpoint between upregulated IRS and CIRS components. In FEP, increased baseline CIRS activity is a protective factor which may predict favorable clinical outcomes. Moreover, impairments in the CIRS are associated with deficit schizophrenia and greater impairments in semantic and episodic memory. It is concluded that CIRS plays a key role in the pathophysiology of schizophrenia by negatively regulating the primary IRS and contributing to recovery from the acute phase of illness. Components of the CIRS may offer promising therapeutic targets for schizophrenia.

Preprint ARTICLE | doi:10.20944/preprints201905.0377.v1

Distinct Subgroups of Amnestic Mild Cognitive Impairment as Identified by Soft Independent Modeling of Class Analogy

Sookjaroen Tangwongchai, Itthipol Tawankanjanachot , Chavit Tunvirachaisakul, Thitiporn Supasitthumrong, Solaphat Hemrungrojn , Phenphichcha Chuchuen , Thiti Snabboon, André Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dementia; AGAP; bicarbonate; cognitive function; Mild cognitive impairment; CERAD

Online: 31 May 2019 (08:31:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0229.v1

Reaching Out to Rural Caregivers and Veterans with Dementia Utilizing Clinical Video-Telehealth

James S. Powers, Jennifer Buckner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: rural health; dementia care; telehealth

Online: 18 April 2018 (05:25:13 CEST)

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Context: A clinical video telehealth (CVT) program was implemented improve access and quality of dementia care to patients and their caregivers in rural areas. The program was offered as part of an established dementia clinic/geriatric primary care clinic in collaboration with five community-based outpatient clinics (CBOC’s) affiliated with the Tennessee Valley Healthcare System (TVHS) in middle Tennessee. Telehealth support was provided by a physician – social worker team visit. Methods: Telehealth training and equipment were provided to clinic personnel, functioning part-time with other collateral clinical duties. Patients and caregivers were referred by primary care providers and had an average of 1 to 2 CVT encounters originating at their local CBOC lasting 20 to 30 minutes. Clinical characteristics and outcomes of patients and caregivers receiving CVT support were collected by retrospective electronic medical record (EMR) review. Results: Over a 3-year period 45 CVT encounters were performed on patient-caregiver pairs, followed for a mean of 15 (1-36) months. Some 80% patients had dementia confirmed and 89% of these had serious medical comorbidities, took an average of 8 medications, and resided at a distance of 103 (76-148) miles from the medical center. Dementia patients included 33% with late stage dementia, 25% received additional care from a mental health provider, 23% took antipsychotic medications, 19% transitioned to a higher level of care, and 19% expired an average of 10.2 months following consultation. Caregiver distress was present in 47% of family members. Consult recommendations included 64% community-based long-term care services and supports (LTSS), 36% medications, and 22% further diagnostic testing. Acceptance of the CVT encounter was 98%, with 8770 travel miles saved. Conclusion: CVT is well received and may be helpful in providing dementia care and supporting dementia caregivers to obtain LTSS for high-need older adults in rural areas.

Preprint ARTICLE | doi:10.20944/preprints201812.0037.v1

The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre A. Geoffroy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: neuroplasticity; neuroprogression; psychiatric disorders; brain economy; severe mental illness; biomarkers

Online: 3 December 2018 (16:18:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0272.v1

Application of Wearables to Improve Uptake of Exercise Therapy during Hemodialysis Treatment for Reducing Depression Symptom – A Single Blinded Randomized Controlled Trial

He Zhou, Fadwa Al-Ali, Gu Kang, Abdullah Hamad, Rania Ibrahim, Tala Talal, Bijan Najafi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Exergame; depression; hemodialysis; end-stage renal disease; wearable technology; digital health

Online: 23 January 2020 (16:29:53 CET)

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Working Paper ARTICLE

Short Form 36-Item Health Survey (SF-36) in Patients with Physical Disabilities: Validity and Reliability

Nassim Ahmadi, Mojgan Rajati, Maryam Khazaei Pool, Leili Salehi, Mohammad Ebrahimi, Fatemeh Rajati

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Disabled Persons; Health Status; Iran; Psychometrics; Quality of Life; Reliability

Online: 7 September 2020 (03:24:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0451.v2

Short but Continuous Natural Pain during Meditation Sittings for Depression Treatment: A Case Report

Mingwei Huang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: pain; depression; treatment; meditation; synaptic plasticity and homeostasis; nerve stimulation

Online: 31 May 2018 (09:56:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0499.v1

Executive Functions and Cannabis Use in Adolescents

Alessandro Frolli, Maria Carla Ricci, Antonella Cavallaro, Agnese Lombardi, Grazia Maria Giovanna Pastorino, Francesca Felicia Operto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: adolescents; cannabis; cognition; working memory; executive functions

Online: 22 July 2020 (05:42:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0423.v1

Social and Emotional Loneliness among Older People Living in Nursing Homes in Spain: A Cross-Sectional Study

Miriam Molas-Tuneu, Javier Jerez-Roig, Eduard Minobes-Molina, Laura Coll-Planas, Anna Escribà-Salvans, Pau Farrés-Godayol, Meltem Yildirim, Sandra Rierola-Fochs, Ester Goutan-Roura, Dyego Leandro Bezerra de Souza, Dawn A. Skelton, Jordi Naudó-Molist

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: emotional loneliness; social loneliness; nursing homes; older adults; social isolation

Online: 27 January 2022 (13:25:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0260.v1

“I’ve only just heard about it”: Complementary and Alternative Medicine Knowledge and Educational Needs of Clinical Psychologists in Indonesia

Andrian Liem

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: complementary and alternative medicine; integrative medicine; knowledge; training and education; psychology; mental health; qualitative

Online: 26 June 2019 (05:31:14 CEST)

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Background and objectives: The inadequate knowledge of complementary and alternative medicine (CAM) among health professionals may put their clients in risky situation because they then would find information about CAM from unreliable sources. Clinical psychologists (CPs), as health professionals, have also the opportunity to provide psychoeducation on the latest CAM scientific research to their clients. The current study aimed to explore knowledge and educational needs of CAM among CPs in Indonesia because previous studies on exploring CAM knowledge and educational needs of CAM were primarily conducted in Western countries. Materials and Methods: Data were collected through semi-structured face-to-face interviews with 43 CPs in public health centers (PHCs) in Indonesia. Most interviews were held at the PHCs where participants worked and interviews lasted for 55 minutes, on average. The interview recordings were transcribed and were analyzed using deductive thematic analysis. Results: Five main themes emerged within participants’ responses regarding CAM knowledge and educational needs. First (CAM understanding), participants’ responses ranged from those with little or no prior knowledge of CAM treatments and uses, to those with much greater familiarity. Second (source of knowledge), participants’ access ranged widely in terms of references, from popular to scientific literature. Third (why is it important?), participants identified CAM essentially as part of Indonesian culture and it was therefore crucial to have this cultural knowledge. Fourth (the challenges and what is needed?), the challenges for improving participants’ knowledge came from personal and institutional levels. Fifth (what and how to learn?), participants advised that only CAM treatments that fit in brief psychotherapy sessions should be introduced in professional training. Conclusions: This qualitative study discovered that CAM was neither well-known nor understood widely. Participants advised that professional associations and health institutions should work together in enhancing knowledge of CAM and incorporating CAM education into psychology education.

Working Paper ARTICLE

The Menstrual Cycle may not Be Limited to the Endometrium but also may Impact Intestinal Permeability

Chutima Roomruangwong, André F. Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual syndrome; depression; anxiety; fatigue; neuro-immune; progesterone

Online: 21 March 2019 (04:13:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0198.v1

Role Identity, Dissonance, and Distress among Paramedics

Justin Mausz, Elizabeth Anne Donnelly, Sandra Moll, Sheila Harms, Meghan McConnell

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Public Safety Personnel; First Responders; Mental Disorders; Mental Health; Well-Being; Trauma; Operational Stress Injuries; Post-Traumatic Stress Injuries; Role Identity Theory; Qualitative Research

Online: 14 January 2022 (08:31:02 CET)

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Preprint REVIEW | doi:10.20944/preprints201811.0506.v2

Sleep Disorders as a Mediator Between Socioeconomic Status and Health Outcomes: A Review of Differents Theories

Faustin Armel Etindele Sosso, Dimitrios Papadopoulos

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: circadian rhythm; sleep disorders; socioeconomic status; stress; allostatic load; health outcome

Online: 10 December 2018 (14:18:30 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202302.0464.v1

Cannabidiol, NegEnt and Panic Disorder

Tullio Scrimali

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: cannabidiol; liposomal cannabidiol; NegEnt; panic disorders; cognitive psychotherapy; alprazolam

Online: 27 February 2023 (09:07:43 CET)

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Working Paper REVIEW

Neuropsin in Mental Health

Lina Bukowski, Ana Chernomorchenko, Anna Starnawska, Ole Mors, Nicklas Heine Staunstrup, Anders D. Børglum, Per Qvist

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: neuropsin; KLK8; mental disorders; mental health

Online: 24 December 2019 (08:53:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0120.v1

Striking a Balance between Work and Play: The Effects of Work-life Interference and Burnout on Faculty Turnover Intentions and Career Satisfaction

Sheila A. Boamah, Hanadi Hamadi, Farinaz Havaei, Hailey Smith, Fern Webb

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Burnout; career satisfaction; COVID-19; faculty shortage; nursing faculty; turnover intentions; work environment; work-life interference

Online: 10 January 2022 (13:58:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0132.v1

Schizophrenia Phenomenology Comprises a Bifactorial General Severity and a Single-group Factor, Which Are Differently Associated with Neurotoxic Immune and Immune-regulatory Pathways

Michael Maes, Aristo Vojdani, Michel Geffard, Estefania Moreira, Decio Sabbatini Barbosa , Ana Paula Michelin , Laura de Oliveira Semeão, Sunee Sirivichayakul, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; inflammation; oxidative stress; neuro-immune; gut bacteria; antioxidants

Online: 11 August 2019 (14:58:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0342.v1

‘I Can’t Breathe’: Anxiety and Emotion Awareness in Older Adolescents at The Time of Covid-19

Pietro Smirni, Gioacchino Lavanco, Daniela Smirni

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 pandemic; virus’ transmission; fear of contagion; breathing difficulty; healthy adolescents; emotion awareness; anxiety-state

Online: 15 August 2020 (08:25:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0464.v1

Post-partum Depression in Mothers of Children under 2 years in Military Barracks in Lagos, Nigeria

Alero Ann Roberts, Chisa Mariam Nworka, Esther Oluwakemi Oluwole, Ezekiel Sofela Oridota

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Postpartum depression, Edinburgh Postpartum Depression Scale, general help-seeking, mothers, military barracks

Online: 27 August 2018 (14:59:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0247.v1

Dietary Supplementation with Omega-3 Polyunsaturated Fatty Acids Reduces Opioid-Seeking Behaviors and Alters the Gut Microbiome

Joshua K. Hakimian, Tien Dong, Jorge A. Barahona, Venu Lagishetty, Suchi Tiwari, Darien Azani, Matthew Barrera, Suhjin Lee, Amie L. Severino, Nitish Mittal, Catherine M. Cahill, Jonathan P. Jacobs, Wendy Walwyn

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: opioid; microbiome-brain axis; DHA; anxiety; polyunsaturated fatty acids; intravenous self-administration; mice

Online: 23 July 2019 (04:09:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0092.v1

Development of a Novel Staging Model for Affective Disorders Using Partial Least Squares Bootstrapping: Effects of Lipid-Associated Antioxidant Defenses and Neuro-Oxidative Stress

Michael Maes, Juliana Brum Moraes , Ana Congio , Kamila Landucci Bonifacio , Decio Sabbatini Barbosa , Heber Odebrecht Vargas , Ana Paula Michelin , Andre F. Carvalho , Sandra Odebrecht Vargas Nunes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: staging, affective disorders, major depression, bipolar disorder, oxidative, neuro-immune

Online: 7 December 2018 (13:56:04 CET)

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