ARTICLE | doi:10.20944/preprints201911.0128.v1
Subject: Biology, Agricultural Sciences & Agronomy Keywords: ditches; grain yield; lodging resistance; root traits; wet-seeded rice
Online: 12 November 2019 (10:25:04 CET)
The mechanical hill wet-seeded rice machine is benefits to establish uniform seedling, and ditches were established by using this machine. However, little knowledge is known on the effect of the establishment of ditches on growth, lodging and yield, and their relationship with root traits. In this study, two field experiments were conducted during 2012 and 2013 with using two super rice varieties (i.e. hybrid rice ‘Peizataifeng’ and inbred rice ‘Yuxiangyouzhan’) grown under three ditches establishment treatments (i.e. T1: both water ditches and seed ditches were established by the machine, T2: seed ditches were established by the machine, T3: neither water nor seed ditches were established by the machine). The lodging index and lodging resistance traits, the grain yield and above-ground dry weight and the root traits were measured. The results showed that the lodging index was significantly affected by the treatments with ditches. The strongest lodging resistance was detected in mechanical hill wet-seeded rice with ditches treatment in both 2012 and 2013. The lodging resistance was strongly related to the breaking resistance, the root volume and root superficial area at the heading stage and maturity stage and the total root length at the heading stage. No significant difference was investigated in grain yield or dry weight of mechanical hill wet-seeded rice. Yuxiangyouzhan showed higher grain yield, dry weight and better lodging resistance but unfavorable root growth attributes than Peizataifeng. Therefore, the mechanical hill wet-seeded rice with ditches treatment increased rice lodging resistance is related to root traits.
ARTICLE | doi:10.20944/preprints201808.0493.v1
Subject: Life Sciences, Genetics Keywords: Weed competitive ability; early seed germination and seedling vigor traits; quantitative trait loci (QTLs); single nucleotide polymorphism; direct seeded rice
Online: 29 August 2018 (10:46:02 CEST)
Weed competitive ability (WCA) is a desirable key trait for the improvement of grain yield under direct-seeded rice (DSR) and the aerobic rice ecosystem. The present study targeted screening of 167 introgression lines (ILs) of a Green Super Rice (GSR) IR2-6 population derived from a cross between Weed Tolerant Rice 1 (WTR1) as the recipient parent and Y134 as the donor parent developed at IRRI for weed competitiveness in screen house conditions (SHC). The ILs were phenotyped for WCA traits such as early seed germination (ESG) and early seedling vigor (ESV) in Petri dishes and pot experiment conditions. The results of phenotypic variance revealed ESG-related traits, especially first germination count (1st GC) that positively correlated with second germination count (2nd GC), germination percentage (GP), total dry weight (TDW), total fresh weight (TFW), and vigor index (VI-1), whereas, in ESV, all the traits were positively correlated with each other except for three traits: root dry weight (RDW), 1st GC, and GP-2. The ESG and ESV traits are vital for weed competitiveness. A 6K SNP array was used to study the genetic association for the WCA traits. Forty-four QTLs for WCA traits were mapped on all chromosomes (except on chromosomes 4 and 8) through single marker analysis (SMA). Out of 44 QTLs, 29 were associated with ESG traits and 15 with ESV traits, with LOD scores of 2.93 to 8.03 and 2.93 to 5.04 and explained phenotypic variance ranging from 7.85% to 19.9% and from 7.85% to 13.2%, respectively. However, 31 QTLs were contributed by a negative additive allele from Y134, whereas a positive additive allele was contributed by WTR1 in 13 QTLs. Among them, two QTL hotspot regions were mapped on chromosome 11 (24.7-27.9 Mb) and chromosome 12 (14.8-17.4 Mb). The majority of the QTLs related to WCA traits were grouped into two QTL hotspots: QTL hotspot-I (qAFW11.1, qFC11.1, qFC11.2, qSC11.1, qGP-111.1, qGP-111.2, qTFGS11.1, qVI-111.1, and qVI-111.2) and QTL hotspot-II (qFC12.1, qFC12.2, qSC12.1, qFC12.2, qGP-112.1, qGP-112.2, qTFGS12.1, qTFGS12.2, qVI-112.1, qIV12.2, qFC12.1, and qGC12.2), and a few of them were co-localized on chromosomes 11 and 12. Further, we fine-tuned in the genomic regions of QTL hotspots and identified a total of 13 putative candidate genes on chromosomes 11 and 12 collectively. The present study is the first report on the genetic basis of WCA-related traits and the co-localized QTLs, which could be highly valuable in future breeding programs aiming to improve WCA in rice.
ARTICLE | doi:10.20944/preprints202210.0354.v1
Online: 24 October 2022 (07:14:38 CEST)
Spider silk has excellent strength and elasticity in natural, researchers have been working for decades try to achieve natural spider silk outstanding mechanical properties using recombinant spider silk protein (spidroin) through artificial spinning. In this work, we chose wet spinning method to explore the relationship between concentration of coagulation bath and fiber performance. It was found that the concentration of methanol has important effect on fiber continuity, diameter and mechanical properties. Lower concentration favors spinning continuous thinner, fibers with high strain. Secondary stretching benefits spinning silk fibers with stable mechanical properties, and thermal stability. Through applying different methanol concentration and additional stretching, we obtained silk fibers with Young’s modulus of 3.052± 2.626 GPa, stress of 25.3944 ± 17.48 MPa, and strain of 140 ± 95.4%.
ARTICLE | doi:10.20944/preprints202212.0388.v1
Subject: Chemistry, Chemical Engineering Keywords: alumina; Bayer process; bauxite; seeded precipitation; coarse gibbsite; agglomeration.
Online: 21 December 2022 (06:56:02 CET)
The addition of active seed for increasing the precipitation rate leads to the formation of fine Al(OH)3 particles that complicates separation of solid from the mother liquor. In this study, the enhanced precipitation of coarse Al(OH)3 from sodium aluminate solution using active agglomerated seed was investigated. Aluminum salt (Al2(SO4)3) were used for active agglomerated seed precipitation at the initial of the process. About 50% of precipitation rate was obtained when these agglomerates were used as a seed in the amount of 20 g L–1 at 25 °C within 10 h. The agglomerated active seed and precipitate samples were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). SEM images showed that agglomerates consist of flake-like particles that can be stick together by bayerite (β-Al(OH)3) acting as a binder. The precipitation temperature above 35 °C and the high concentration of free alkali (αk > 3) lead to the agglomerates refinement that can be associated with the bayerite dissolution.
ARTICLE | doi:10.20944/preprints201805.0420.v1
Subject: Engineering, General Engineering Keywords: wet agglomeration; flocculation; hydrodynamics; turbulence
Online: 29 May 2018 (09:00:36 CEST)
In this study, an experimentally validated computational model was developed to investigate the hydrodynamics in a rotor-stator vortex RVR agglomeration reactor having a rotating disc at the centre with two shrouded outer plates. A numerical simulation was performed using a simplified form of the reactor geometry to compute the 3D flow field in batch mode operations. Thereafter, the model was validated using data from a 2D Particle Image Velocimetry (PIV) flow analysis performed during the design of the reactor. Using different operating speeds—70, 90, 110 and 130 rpm, the flow fields were computed numerically followed by a comprehensive data analysis. The simulation results showed separated boundary layers on the rotating disc and the stator. The flow field within the reactor is characterized by a rotational plane circular forced vortex flow in which the streamlines are concentric circles with a rotational vortex. Overall, the results of the numerical simulation demonstrate a fairly good agreement between the CFD model and the experimental data as well as the available theoretical predictions. The swirl ratio β was found to be approximately 0.4044, 0.4038, 0.4044 and 0.4043 for operating speeds of N=70, 90, 110 and 130 rpm respectively. In terms of the spatial distribution, the turbulence intensity and kinetic energy are concentrated on the outer region of the reactor while the axial velocity showed a decreasing intensity towards the shroud. However, a comparison of the CFD and experimental predictions of the tangential velocity and the vorticity amplitude profiles shows that these parameters were under-predicted by the experimental analysis which could be attributed to some of the experimental limitations rather than the robustness of the CFD model or numerical code.
Subject: Materials Science, Biomaterials Keywords: metallic nanoparticle-polymer hybrids; seeded precipitation polymerization; core-shell nanomaterials; plasmonic nanomaterials
Online: 13 January 2021 (11:09:46 CET)
The implementation of gold-hydrogel core-shell nanomaterials in novel light-driven technologies requires the development of well-controlled and scalable synthesis protocols with precisely tunable properties. Herein, new insights are presented concerning the importance of using the concentration of gold cores as a control parameter in the seeded precipitation polymerization process to modulate – regardless of core size – relevant fabrication parameters such as encapsulation yield, particle size and shrinkage capacity. Controlling the number of nucleation points results in the facile tuning of the encapsulation process, with yields reaching 99% of gold cores even when using different core sizes at a given particle concentration. This demonstration is extended to the encapsulation of bimodal gold core mixtures with equally precise control on the encapsulation yield, suggesting that this principle could be extended to encapsulating cores composed of other materials. These findings could have significant impact on the development of stimuli-responsive smart materials.
ARTICLE | doi:10.20944/preprints202102.0450.v1
Subject: Materials Science, Biomaterials Keywords: Wet spinning; Lanthanum oxide; Biochar; Chromate; Adsorption
Online: 22 February 2021 (08:51:53 CET)
Lanthanum chemical compound incorporates a sensible anionic complexing ability, however lacks stability at low pH scale. Biochar fibers will benefit of their massive space and plethoric useful teams on surface to support metal chemical compound. Herein, wet spinning technology was used to load La3+ onto sodium alginate fiber, and convert La3+ into La2O3 through carbonization. The La2O3 modified biochar (La-BC) fiber was characterized by SEM, XRD and XPS, etc. The adsorption experiment proved that La-BC showed excellent adsorption capacity for chromates, and its saturation adsorption capacity was about 104.93mg/g. The information suggested that the adsorption was in step with both Langmuir and Freundlich model, followed pseudo-second-order surface assimilation mechanics, which instructed that the Cr (VI) adsorption was characterized by single-phase and polyphase adsorption, mainly chemical adsorption. Thermodynamic parameter proved that the adsorption process was spontaneous and endothermic. The mechanistic investigation revealed that the mechanism of adsorption of Cr (VI) by La-BC may include electrostatic interaction, ligand exchange or complexation. Moreover, co-existing anions and regeneration experiments proved that La-BC was recyclable and had a good prospect in the field of chrome-containing wastewater removal.
ARTICLE | doi:10.20944/preprints201702.0081.v1
Subject: Earth Sciences, Atmospheric Science Keywords: reference evapotranspiration; climatic change; drought/wet; Songnen Grassland
Online: 22 February 2017 (16:46:01 CET)
Reference evapotranspiration (ET0) plays an irreplaceable role in regional dry/wet conditions under the background of climate change. Based on the FAO Penman-Monteith method and daily climate variables, ET0 was calculated for 22 stations in and around Songnen Grassland, northeast China, during 1960-2014. The temporal and spatial variations of ET0 and precipitation (P) were comprehensively analyzed at different time scales by using the Mann-Kendall test, Sen’s slope estimator, and linear regression coupling with break trend analysis. Sensitivity analysis was used to detect the key climate parameter attributed to ET0 change. Then, the role of ET0 in regional dry/wet conditions was discussed by analyzing the relationship between ET0, P and aridity index (AI). Results shown a higher ET0 in the southwest and a lower in the northeast, but P was opposite to that of ET0. Evidently decreasing trend of ET0 at different time scales was detected in almost the entire region, and the significant trend mainly distributed in the eastern, northeastern and central. For the whole region, sensitivity analysis indicated decreasing trend of ET0 was primarily attributed to relative humidity and maximum air temperature. The positive contribution of increasing temperature rising to ET0 was offset by the effect of significantly decreasing relative humidity, wind speed and sunshine duration. In addition, the value of ET0 shown higher in drought years and lower in wet years.
COMMUNICATION | doi:10.20944/preprints202109.0133.v1
Subject: Medicine & Pharmacology, Clinical Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia
Online: 7 September 2021 (16:26:51 CEST)
The Lewy Body Dementia Association (LBDA) held a virtual event, the LBDA Biofluid/Tissue Biomarker Symposium, on January 25, 2021, to present advances in biomarkers for Lewy Body Dementia (LBD), which includes Dementia with Lewy Bodies (DLB) and Parkinson's Disease Dementia (PDD). The meeting featured eight internationally known scientists from Europe and the United States and attracted over 200 scientists and physicians from academic centers, the National Institutes of Health and the pharmaceutical industry. Methods for confirming and quantifying the presence of Lewy body and Alzheimer pathology as well as novel biomarkers were discussed.
Subject: Engineering, Automotive Engineering Keywords: Window Performance; Cold Air Film; U-Value; Wet hey
Online: 25 May 2021 (11:51:48 CEST)
The concept of this prototype is to create a cold air film layer, in indoor side of the window. The function of this extra cold air layer is to increase the amount of window resistance and decrease its U-Value. It provide air film layer by using the same concept of desert cooler or wind catcher. They both bring the hot air from outside then let it go throw straw miost with cold water. After hot air move through straw, it would become cold, thus increase the window resistance and decrease the haet gian, therefore, decrease the cooling load. So, this window model works by heating the air in air room by sun radiation, then after a while, air pressure will rise and its volume will increase then it will impulse to wet hay, and become cold. Then there is fins to guide air flow to its correct direction, thus inner side of window will become cold, not like other type of window which when temperature rise, the inner side of window become hot. So, this window prevents heat transition and creare regenereted trubouland air flim in the inner side of the window. Using calculation to find air film characteristics and WINDOW7.7 software to calculate heat gain through window, shows that it is expected from this prototype to reduce heat gain by 6.85 % for double glazed clear window.
ARTICLE | doi:10.20944/preprints202101.0333.v2
Subject: Chemistry, Applied Chemistry Keywords: Wet chemical deposition; crystalline thin films; vanadium dioxide; thermochromism
Online: 17 February 2021 (10:38:44 CET)
In this paper, a novel synthesis for a chemical precursor for nanocrystalline VO2 coatings is elaborated. The compatibility of the precursor towards the substrate is optimized for spin coating. This is done by subjecting multiple solvents to contact angle measurements. A suitable thermal treatment is developed to densify the coating and to induce crystallization. Afterwards the microstructure of the coating is investigated using X-Ray diffraction, electron microscopy and ellipsometry techniques. To assess the thermochromic properties of the fabricated device, optical transmission experiments were conducted both at room temperature and at elevated temperature. A correlation between these thermochromic properties and coating thickness was investigated in order to obtain an optimized thermochromic device, where both high visual transparency and prominent thermochromic switching abilities are aimed for. In this work, an optimal coating thickness is proposed for a thermochromic coating with high switching ability and solar modulation.
ARTICLE | doi:10.20944/preprints202002.0075.v2
Subject: Mathematics & Computer Science, Algebra & Number Theory Keywords: wet-bulb depression; relative humidity; ANFIS; artificial neural network; LSSVM
Online: 2 November 2020 (09:44:25 CET)
The main parameters for calculation of relative humidity are the wet-bulb depression and dry bulb temperature. In this work, easy-to-used predictive tools based on statistical learning concepts, i.e., the Adaptive Network-Based Fuzzy Inference System (ANFIS) and Least Square Support Vector Machine (LSSVM) are developed for calculating relative humidity in terms of wet bulb depression and dry bulb temperature. To evaluate the aforementioned models, some statistical analyses have been done between the actual and estimated data points. Results obtained from the present models showed their capabilities to calculate relative humidity for divers values of dry bulb temperatures and also wet-bulb depression. The obtained values of MSE and MRE were 0.132 and 0.931, 0.193 and 1.291 for the LSSVM and ANFIS approaches respectively. These developed tools are user-friend and can be of massive value for scientists especially, those dealing with air conditioning and wet cooling towers systems to have a noble check of the relative humidity in terms of wet bulb depression and dry bulb temperatures.
ARTICLE | doi:10.20944/preprints202001.0383.v1
Subject: Earth Sciences, Environmental Sciences Keywords: bioretention; nitrogen removal; submerged zone; alternate wet and dry conditions
Online: 31 January 2020 (11:31:15 CET)
Adding a submerged zone (SZ) is deemed to promote denitrification during dry periods and thus improve NO3--N removal efficiency of a bioretention system. However, few studies had investigated the variation of nitrogen concentration in the SZ during dry periods and evaluated the effect of the variation on nitrogen removal of the bioretention system. Based on the experiment in a mesocosm bioretetion system with SZ, this study investigated the variation of nitrogen concentration of the system under 17 consecutive cycles of wet and dry alternation with varied rainfall amount, influent nitrogen concentration and antecedent dry periods (ADP). The results indicated that (1) during the dry periods, NH4+-N concentrations in SZ showed an exponential decline trend, decreasing by 50% in 12.9 ± 7.3 hours; while NO3--N concentrations showed an inverse S-shape decline trend, decreasing by 50% in 18.8 ± 6.4 hours; (2) during the wet periods, NO3--N concentration in the effluent showed an S-shape upward trend; and at the early stage of the wet periods, the concentration was relatively low and significantly correlated with ADP, while the corresponding volume of the effluent was significantly correlated with the SZ depth; (3) in the whole experiment, the contribution of nitrogen decrease in SZ during dry periods to NH4+-N and NO3--N removal accounted for 12% and 92%, respectively; and the decrease of NO3--N in SZ during the dry period was correlated with the influent concentration in the wet period and the length of the dry period.
ARTICLE | doi:10.20944/preprints201701.0014.v1
Subject: Earth Sciences, Environmental Sciences Keywords: rainwater; weather; windbreaker; cup anemometer; dry and wet bulb thermometers
Online: 4 January 2017 (07:27:41 CET)
Agro-meteorology is the relationship between agriculture and weather. All farm activities are affected by weather. Therefore it is always necessary to monitor the weather as a forecast. The aim of the research was to monitor the weather and rainwater samples obtained at Federal College of Agriculture, Akure, Ondo State, Nigeria. For the eight months periods, results were obtained. The mean results for the physicochemical parameters were: TDS (12.25 mg/L), temp (28.13 oC), pH (6.63), EC (24.25µS/cm), Free CO2 (24.38mg/L), nitrate (0.16mg/L), phosphate (0.17mg/L), sulphate (0.18mg/L). The rainwater was colorless and had no odor. The mean meteorological data: The prevailing wind directions were from SE, mostly in May, June, July and November and NE. The dry and wet temperatures were 22-29 oC and 20-26 oC respectively. The maximum value was observed in the month of July. The correlation matrix showed that there were many strong correlations in the physicochemical properties. The months of May, June and July had the highest wind speed. In these months there would be a need to use a windbreaker around the crops planted to avoid soil erosion and damaging of plants.
ARTICLE | doi:10.20944/preprints202203.0075.v1
Subject: Life Sciences, Biotechnology Keywords: Algae; wet anaerobic storage; dry matter loss; organic acid; lactic acid bacteria
Online: 4 March 2022 (08:45:40 CET)
Wet anaerobic storage of algal biomass is a promising preservation approach which can ensure continuous supply of these feedstocks to biorefineries year-round. An effective solution to preservation must ensure minimal dry matter loss and change in biochemical composition during storage. Therefore, the objective of this study was to investigate the preservation of Nannochloropsis gaditana biomass through wet anaerobic storage and its impact on biomass quality. Prior to storage, algae sample was inoculated with two different strains of lactic acid bacteria and thereafter stored for 30 and 180 days. Each inoculant limited dry matter loss to <10% (dry basis) after the storage durations. Final pH values (4.3 - 4.8) indicate that the biomass samples were properly ensiled, achieving the acidic conditions necessary for preservation. Compositional analysis of the biomass after storage showed a reduction in carbohydrate content, a relative increase in lipid content, and no significant change to the protein fraction. Glucose and galactose were the prevalent sugar monomers. The low dry matter loss and minimal compositional change indicates that wet anaerobic storage is an effective means of preserving algal biomass, ensuring a constant supply of algal biomass feedstock to a biorefinery.
REVIEW | doi:10.20944/preprints202108.0134.v1
Subject: Materials Science, Biomaterials Keywords: Methylcellulose; cellulose nanocrystal; hydrogel; birefringence; wet-spinning; optical fiber; thermoresponsive; LCST; nanocomposite
Online: 5 August 2021 (10:15:49 CEST)
Chemical modification of cellulose offers routes for structurally and functionally diverse biopolymer derivatives for numerous industrial applications. Among cellulose derivatives, cellulose ethers have found extensive use, such as emulsifiers, in food industries and biotechnology. Methylcellulose, one of the simplest cellulose derivatives, has been utilized for biomedical, construction materials and cell culture applications. Its improved water solubility, thermoresponsive gelation, and the ability to act as a matrix for various dopants also offer routes for cellulose-based functional materials. There has been a renewed interest in understanding the structural, mechanical, and optical properties of methylcellulose and its composites. This review focuses on the recent development in optically and mechanically tunable hydrogels derived from methylcellulose and methylcellulose-cellulose nanocrystal composites. We further discuss the application of the gels for preparing highly ductile and strong fibers. Finally, the emerging application of methylcellulose-based fibers as optical fibers and their application potentials are discussed.
Subject: Keywords: clay; mica; biotite; muscovite; origin of life; abiogenesis; mechanical energy; work; wet-dry
Online: 5 November 2020 (10:43:44 CET)
This paper presents a hypothesis about the origins of life in a clay mineral, starting with the earliest molecules, continuing through the increasing complexity of the development, in neighboring clay niches, of “Metabolism First,” “RNA World,” and other necessary components of life, to the encapsulation by membranes of the components in the niches, to the interaction and fusion of these membrane-bound protocells, resulting finally in a living cell, capable of reproduction and evolution. Biotite (black mica) in micaceous clay is the proposed site for this origin of life. Mechanical energy of moving biotite sheets provides one endless source of energy. Potassium ions between biotite sheets would be the source of the high intracellular potassium ion concentrations in all living cells.
ARTICLE | doi:10.20944/preprints202001.0300.v1
Subject: Earth Sciences, Other Keywords: snow; synthetic aperture radar; Sentinel-1; spatial variability; spectral scaling; topography; wet snow
Online: 26 January 2020 (01:42:48 CET)
This study investigates the spatial signatures of seasonal snow in Synthetic Aperture Radar (SAR) observations at different spatial scales and for different physiographic regions. Sentinel-1 C-band (SAR) backscattering coefficients (BSC) were analyzed in the Swiss Alps (SA), in high elevation forest and grasslands in Grand Mesa (GM), Colorado, and in North Dakota (ND) croplands. GM BSC exhibit 10dB sensitivity to wetness at small scales (~100 m) over homogeneous grassland. Sensitivity decreases to 5 dB in the presence of trees, and it is demonstrated that VH BSC sensitivity enables wet snow mapping below the tree-line. Area-variance scaling relationships show minima at ~100 m and 150-250 m respectively in barren and grasslands in SA and GM, increasing up to 1 km and longer in GM forests and ND agricultural fields. The spatial organization of BSC (as described by 1D-directional BSC wavelength spectra) exhibits multi-scaling behavior in the 100 -1,000 m range with a break at (180-360 m) that is also present in UAVSAR L-band measurements in GM. Spectral slopes in GM forested areas steepen during accumulation and flatten in the melting season with mirror behavior for grasslands reflecting changes in scattering mechanisms with snow depth and wetness, and vegetation mass and structure. Overall, this study reveals persistent patterns of SAR scattering variability spatially organized by land-cover, topography and regional winds with large inter-annual variability tied to precipitation. This dynamic scaling behavior emerges as an integral physical expression of snowpack variability that can be used to model sub-km scales and for downscaling applications.
ARTICLE | doi:10.20944/preprints202201.0022.v1
Subject: Life Sciences, Biophysics Keywords: clay; mica; biotite; muscovite; origin of life; abiogenesis; mechanical energy; work; wet-dry cycles
Online: 4 January 2022 (20:36:31 CET)
Intracellular potassium concentrations, [K+], are high in all types of living cells, but the origins of this K+ are unknown. The simplest hypothesis is that life emerged in an environment that was high in K+. One such environment is the spaces between the sheets of the clay mineral, mica. The best mica for life’s origins is the black mica, biotite, because it has a high content of Mg++ and it has iron in various oxidation states. Life also has many of the characteristics of the environment between mica sheets, giving further support for the possibility that mica was the substrate on and within which life emerged.
ARTICLE | doi:10.20944/preprints202106.0585.v1
Subject: Medicine & Pharmacology, Allergology Keywords: Triamcinolone acetonide; Liposomes; Neovascular age related macular degeneration; Wet macular degeneration; Adjuvant therapy; Ranibizumab
Online: 23 June 2021 (12:56:55 CEST)
Novel strategies have been developed to reduce or to avoid the intravitreal injections (IVTs) of the antiangiogenic (ranibizumab; RBZ) and the anti-inflammatory (triamcinolone acetonide; TA) agents used to treat vitreoretinal diseases. One of the strategies include liposomes. In this study, it was evaluated the safety and efficacy of topical triamcinolone-loaded liposomes formulation (TALF) as an adjuvant to intravitreal RBZ therapy in treatment-naive patients with neovascular age related macular degeneration (nAMD). Subjects were randomly assigned to the RBZ-TALF or the RBZ-pro re nata (RBZ-PRN) group. Patients from the RBZ-TALF group were instructed to apply TALF for a 12-month period after a single dose of RBZ. Patients from the RBZ-PRN group received three monthly RBZ-IVTs. Retreatment with RBZ was considered in case of nAMD reactivation. Related to safety, non-ocular abnormalities were observed during TALF therapy. Owing to the efficacy, non-significant differences are identified in visual acuity or central foveal thickness when the RBZ-PRN and RBZ-TALF groups are compared. Importantly the average number of RBZ injections was significantly lower in the RBZ-TALF group (2.5 ± 1.4 vs 6.1 ± 1.3 IVTs; p=0004). Therefore, TALF used as an adjuvant to RBZ reduce the number of RBZ-IVTs retreatment with optimal visual and anatomic results.
ARTICLE | doi:10.20944/preprints202106.0120.v1
Subject: Earth Sciences, Atmospheric Science Keywords: IMERG; Stage IV; Infrared; Passive microwave; Snow; Ice; Precipitation; GPM; Wet-bulb temperature; AMSR-2
Online: 3 June 2021 (14:59:21 CEST)
Various products of the Integrated Multisatellite Retrievals for GPM (IMERG) and passive mi-crowave (PMW) sensors are assessed with respect to near-surface wet-bulb temperature (Tw), precipitation intensity, and surface type (i.e., with and without snow and ice on the surface) over the CONUS and using Stage-IV product as reference precipitation. IMERG products include precipitation estimates from infrared (IR), combined PMW, and their combination. PMW products generally have higher skills than IR over snow- and ice-free surfaces. Over snow- and ice-covered surfaces (1) PMW products (except AMSR-2) show a higher correlation coefficient than IR, (2) IR and PMW precipitation products tend to overestimate precipitation, but at colder temperatures (e.g., Tw<-10oC) PMW products tend to underestimate and IR product continues to show large overestimations, and (3) PMW sensors show higher overall skill in detecting precipitation oc-currence, but not necessarily at very cold Tw. The results suggest that the current approach of IMERG (i.e., replacing PMW with IR precipitation estimates over snow- and ice-surfaces) may need to be revised.
ARTICLE | doi:10.20944/preprints201904.0297.v1
Subject: Chemistry, Other Keywords: hyperbranched polyester; functional polymer; chemical evolution; wet-dry cycle; gelation prevention; condensation polymer; origin of life
Online: 26 April 2019 (10:46:40 CEST)
In extant biology, biopolymers perform multiple crucial functions. The biopolymers are synthesized by enzyme-controlled biosystems that would not have been available at the earliest stages of chemical evolution and consist of correctly sequenced and/or linked monomers. Some of the abiotic “messy” polymers approximate some functions of biopolymers. Condensation polymers are an attractive search target for abiotic functional polymers since principal polymers of life are produced by condensation and since condensation allows for the accurate construction of high polymers. Herein the formation of hyperbranched polyesters that have been previously used in the construction of enzyme-like catalytic complexes is explored. The experimental setup compares between the branched polyesters prepared under mild continuous heating and the wet-dry cycle conditions. The results reveal that period wetting during which partial hydrolysis of the polyester occurs, helps control the chain growth and retards the gel transition. It is significant to the origin of life studies that environmental, prebiotically plausible conditions could achieve such control without enzymes or a skilled chemist. As expected in marginally controlled systems, the identification of each component of the heterogeneous system has proved challenging, but it is not crucial for drawing the conclusions.
COMMUNICATION | doi:10.20944/preprints202002.0057.v1
Subject: Materials Science, Biomaterials Keywords: porous fibers; activated carbon; ice-templating; ice segregation induced self-assembly; silk fibroin; wet spinning; solution blow spinning
Online: 5 February 2020 (10:38:29 CET)
Fabrics comprised of porous fibers could provide effective passive protection against chemical and biological (CB) threats whilst maintaining high air permeability (breathability). Here, we fabricate hierarchically porous fibers consisting of regenerated silk fibroin (RSF) and activated-carbon (AC) prepared through two fiber spinning techniques in combination with ice-templating – namely cryogenic solution blow spinning (Cryo-SBS) and cryogenic wet-spinning (Cryo-WS). The Cryo-WS RSF fibers had exceptionally small macropores (as low as 0.1 µm) and high specific surface areas (SSAs) of up to 79 m2 g-1. The incorporation of AC could further increase the SSA to 210 m2 g-1 (25 wt. % loading) whilst also increasing adsorption capacity for volatile organic compounds (VOCs).
Subject: Life Sciences, Molecular Biology Keywords: origin of life; origins of life; mechanical energy; work; entropic forces; mica; biotite; Muscovite; wet/dry cycles; clay
Online: 29 April 2019 (07:51:38 CEST)
Forces and mechanical energy are prevalent in living cells. This may be because forces and mechanical energy preceded chemical energy at life’s origins. Mechanical energy is more readily available in non-living systems than the various other forms of energy used by living systems. Two possible prebiotic environments that might have provided mechanical energy are hot pools that experience wet/dry cycles and mica sheets as they move, open and shut, as heat pumps or in response to water movements.
ESSAY | doi:10.3390/sci2020019
Subject: Keywords: origin of life; origins of life; mechanical energy; mechanochemistry; work; entropic forces; mica; biotite; Muscovite; wet/dry cycles; clay
Online: 25 March 2020 (00:00:00 CET)
Mechanical forces and mechanical energy are prevalent in living cells. This may be because mechanical forces and mechanical energy preceded chemical energy at life’s origins. Mechanical energy is more readily available in non-living systems than the various forms of chemical energy used by living systems. Two possible prebiotic environments that might have provided mechanical energy are hot pools that experience wet/dry cycles and mica sheets as they move, open and shut, as heat pumps or in response to water movements.