This study aims to determine the Antecedent of employee engagement among police officers in Tanjung Perak Police Station. The approach used in this research is quantitative with survey and correlation methods. The sampling technique used is purposive sampling which obtained by respondents as many as 146 employees of Police officers in Tanjung Perak Police Station which include all the population. The data analysis technique used in this research is descriptive statistics and inferential statistical analysis. Inferential statistical analysis using Structural Equation Modeling (SEM) approach using Smart PLS application. Furthermore, the measurement of the model (outer model). The test findings suggest that internal and external job transitions improve capital mobility. Movement capital boosts internal employability. Movement capital boosts external employability. Employee engagement and participation are negatively impacted by perceived external employability.

Mass transfer and phase transition have important effect on the velocity of bubble migration in deepwater wellbore, and accurate prediction of bubble migration velocity is crucial for calculating the safe shut-in period of deepwater oil and gas well. Therefore, the effect of bubble dissolution mass transfer and hydrate phase transition on bubble migration behavior in deepwater environment have attracted extensive attention from researchers in the fields of energy, marine chemistry, and marine engineering safety. In this work, a new model of bubble migration velocity in deepwater is developed, which considers the effect of hydrate phase transition and gas-water bidirectional cross-shell mass transfer during bubble migration. Based on the observation data of bubble migration in deepwater, the reliability of the model in predicting bubble migration velocity is verified. Then, the model is used to calculate and analyze the bubble migration velocity and bubble migration cycle under different initial bubble size, different annular fluid viscosity and density. The results show that the initial size of bubble and the viscosity of annulus fluid are the main factors affecting the migration velocity of bubble, but the density of annulus fluid has little effect on the migration velocity of hydrated bubble and clean bubble. In addition, the migration velocity of clean bubble gradually increases during the migration process from the bottom to the wellhead, while the migration velocity of hydrated bubble is divided into gradually decreasing stage and slowly increasing stage. The gas consumption and the thickening of hydrate shell in the gradually decreasing stage play a dominant role, and the increase of bubble volume caused by the decrease of pressure in the slowly increasing stage is the most important factor. The formation of hydrated bubble can significantly reduce the migration velocity of bubble and effectively prolong the safe shut-in period. This study provides a reference for quantitative description and characterization of complex bubble migration behavior with phase change and mass transfer in deepwater environment.

The direct measurements of the magnetocaloric effect were performed in Heusler Ni44.4Mn36.2Sn14.9Cu4.5 alloy at cryogenic temperatures in magnetic fields up to 10 T. The maximum value of the inverse magnetocaloric effect in a field of 10 T was observed ∆Tad = –2.7 K in the vicinity of the 1st order magnetostructural phase transition at T0 = 117 K. The ab initio and Monte Carlo calculations were performed to discuss the effect Cu doping into Ni-Mn-Sn compound on the ground state structural and magnetic properties. It is shown that with increasing Cu content the martensitic transition temperature decreases and the Curie temperature of austenite slightly increases. In general, calculated transition temperatures, magnetization values are correlated well with the experimental ones.

Water conflicts have been a significant issue in Brazil, especially in the Sao Francisco River basin. Subseasonal forecasts, up to a 60-day forecast range, can provide information to support decision-makers in managing water resources in the river basin, especially before drought events. Predictability in the subseasonal forecasts range is a research topic as this range contains mixed dependence on weather and seasonal phenomena. Numerical models may inherit this mixed dependence on their skills. The objective of this paper is to evaluate the Eta Model simulations to reproduce the drought events between the years 2011 and 2016. Two sets of 60-day simulations were produced; one started in September (SO) and the other in January (JF) each year. These months were chosen to evaluate the model skill to reproduce the onset and the middle of the rainy seasons in Central Brazil, where the Upper Sao Francisco River is located. The SO simulations reproduced the observed spatial distribution of precipitation but underestimated the amounts. Precipitation errors exhibit large variability across the subbasins. The JF simulations also reproduced the observed precipitation distribution but overestimated it in the Upper and Lower subbasins. The JF simulations better captured the interannual variability of precipitation. The 60-day simulations were discretized in six 10-day accumulations to assess the intra-monthly variability. They showed that simulations can capture the onset of the rainy season and the small amounts of the rainy months that occurred in these severe drought years.

Canine mammary tumors represent one of the leading malignant pathology in female dogs, displaying the importance of efficient therapeutic findings, beside the golden standard surgery, able to limit the development of the disease. Studies in human cancers demonstrated that Doxorubicin presents a good effect in different biological processes like apoptosis, autophagy, cell cycle, cell invasion and epithelial to mesenchymal transition. Our study following the effects of Doxorubicin on two canine mammary cancer cell lines P114 and CMT-U27, showing an inhibitory effect in cell proliferation and an expression alteration of the EMT related genes.

A global existential and interlocking environmental, climate and cooperation/equity polycrisis is being faced, which increasingly impacts and is impacted by water and land systems. As a result, transformations in response are gaining increasing traction. Advances in approaches to visualising and communicating how innovations and changes in landscape features enable shifts, transformations and transitions are more crucial than ever before. Visions help focus actions, collaboration and alignment of multiple actors in working towards a common purpose, whilst also entering people’s consciousness at the deep level of values, transforming beliefs and consequently, thinking and action. They give direction on effort and pull on transformational innovation. The evidence-based ‘Water Visions Visualisation Platform’ presents an innovative and accessible way to illustrate, communicate and support future water visioning and strategizing at the landscape scale based on composite paradigms, scenarios, horizons and concepts. Plausible visions of the future are envisioned, illustrated, narratively described and qualitatively assessed, as well as connected with real-world examples and resources through the interactive Platform. This paper outlines the co-creation methodology, the architecture and the co-development of the Platform, as well as a preliminary evaluation through literature-based criteria and the sharing of the Platform with a number of audiences.

Compared to other 2D materials, MBenes are at an early stage in both experimental and theoretical approaches. However, the wide range of possible 2D structures leads to novel and challenging properties and their consequent applications. From all the possible stoichiometries, we have performed a theoretical study of orthorhombic and hexagonal M2B2 MBenes in the framework of the Density Functional Theory. We have found that both symmetries of Cr2B2, Fe2B2, and Zr2B2 show a metallic behavior and could be grown under certain conditions, as they are demonstrated to be dynamically stable. Moreover, the values of the magnetic moment, in specific ferromagnetic cases exceeding 2.5 μB/M2B2, make them suitable as robust 2D magnets. All our findings represent an important step in the understanding of MBenes and open several windows to future research in fields like energy conversion and storage, sensing, catalysis, biochemistry, or nanotechnology, among others.

Meiosis is a specialized cell division that produces haploid gametes from diploid germ cells, and the phosphorylation activity of cyclin-CDK complexes and Polo-like kinase is required for synaptonemal complex (SC) disassembly and metaphase I exit. Here, we identified a novel protein MSCDK (meiotic substrate of cyclin dependent kinase) that functions as a substrate of CDK1 in initiating SC disassembly and metaphase I transition during meiosis prophase I in mice. Deletion of MSCDK caused germ cell death and infertility in males but not females. Mechanistically, we show that MSCDK is sparsely localized as discrete foci along synaptic homologous chromosomes from the early zygotene to the early diplotene, and we confirm that MSCDK can be phosphorylated by CDK1 and dephosphorylated by the cell cycle exit regulator phosphatase PP1α. We also provide evidence that MSCDK is essential for SC disassembly based on its dephosphorylation-related function, which apparently promotes HSPA2 nuclear recruitment.

Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy, largely due to metastasis and drug resistant recurrences. Fifteen percent of ovarian tumors carry mutations in BRCA1 or BRCA2, rendering them vulnerable to treatment with PARP inhibitors such as olaparib. Recent studies have shown that TGFβ can induce “BRCAness” in BRCA wild-type cancer cells. Given that TGFβ is a known driver of epithelial to mesenchymal transition (EMT), and the con-nection between EMT and metastatic spread in EOC and other cancers, we asked if TGFβ and EMT alter susceptibility of EOC to PARP inhibition. Epithelial EOC cells were transiently treated with soluble TGFβ and their clonogenic potential, expression and function of EMT and DNA repair genes, and response to PARP inhibitors compared with untreated controls. A second epithelial cell line was compared to its mesenchymal derivative for EMT and DNA repair gene expression and drug responses. We found that TGFβ and EMT resulted in downregulation of genes responsible for homologous recombination (HR) and sensitized cells to olaparib. HR efficiency was reduced in a dose-dependent manner. Furthermore, mesenchymal cells displayed sensitivity to olaparib, cis-platin, and the DNA-PK inhibitor Nu-7441. Therefore, treatment of disseminated, mesenchymal tumors may represent an opportunity to expand clinical utility of PARP inhibitors and similar agents.

On a rotating disk, two particles bounce at the vertices of a regular polygon in opposite directions. On the return to the entry point, a clock measures the time difference, called Sagnac effect. Due to Coriolis effects, the counterclockwise and clockwise paths are different. The particular case of the slow disk where the two trajectories are very close and almost polygonal is studied. The existence of a transition between a classical and a relativistic regime is proved. An experimental verification is proposed. Although the two Sagnac effects seem analogous, in detail their behavior is quite different.

The gauge field equation for fluid mechanics established in Part 1 is developed into a first-order scattering theory in the simplified case of a two-dimensional incompressible flow over a flat plate. This is used to present a model for the origin of Tollmien-Schlichting (TS) waves based on scattering between fluid particles. As a result, analytical formulae for the maximum amplification factor and the transition point from laminar to turbulent flow in the boundary layer are obtained. The mathematical transformations from the stationary field equations in Part 1 to a scattering theory with time evolution along the flow axis using Wick rotation are elaborated in detail.

This article is a followup to an earlier review which outlined some of the interesting features of the soliton/wave-action potential (AP) model, and noted the need to test its key aspects; including the need to test if its presumed lipid phase transition is actually happening during AP firings in excitable cells. The intent here is to point out the sort of tests, and evidence from them, that might be needed if the soliton/wave-AP model is to be accepted broadly by biologists. Here, after an overview of the modern electrophysiological-AP model and of the soliton/wave-AP model, there are three areas considered. First, possible compositional influences on membrane properties relative to the soliton/wave-AP model are presented. Including questions with regard to the soliton/wave-AP model’s assumption that changes in surface potentials influence the transmembrane potential. Second, some recent work from the good folks who advocate for the soliton/wave-AP model concerning the occurrence of lipid phase transitions in neurons or in extracts from nervous tissues are examined. Here it is noted that there is a need to consider whether these lipid phase transitions happen within normal physiological conditions or not. Third, and finally, the advocates for the soliton/wave-AP model have adopted a thermodynamic/theory-based philosophical approach in their studies. It is argued that this philosophical approach is a radical departure from the philosophical approach used under the scientific method. The features of this new approach, and implications its use, are examined.

Stemming from the Bulgarian case study developed within a European research project (ECHOES, Horizon 2020), the paper discusses the links between: (a) the urgent need to operationalize EU energy transition policy in the housing domain; (b) the complexity of factors influencing the policy implementation in different contexts – geographical, economic, and technical but also social and cultural; and (c) the important role of the urban level in policy implementation. Under the specific spatial planning context of Bulgaria, the local collective energy-related decision-making in the housing field evolves through the interaction – formal (at the municipal level of governance) and informal (individuals, households and homeowners’ associations taking decisions on self-organization and collective action). The authors claim that interdisciplinary context-sensitive research would contribute to a better understanding for the ongoing energy-related decision-making processes at the local level and would enable the development and implementation of effective and efficient policy instruments in support of energy transition in the housing sector in Europe.

Offshore grids can have a key role in the transition of the energy system to sustainability. Although they require extensive infrastructure investments, they open up for the exploitation of additional resources and may be important to provide for part of the increasing electricity demand driven by sector coupling. This paper quantifies the socio-economic value of offshore grids and identifies their major drivers, performing energy system optimization in a model application of the Northern-central European energy system and the North Sea offshore grid towards 2050. The increasing wake loss with the size of hub-connected wind farms is integrated in the modelling. We find that without sector coupling no offshore grid may develop, and that the higher the level of sector coupling, the higher the value of offshore grids. Therefore, it can be strongly stated that offshore grid infrastructure development should not be discussed as a separate political topic, but seen in connection to sector coupling.

The article is devoted to a bibliometric analysis of scientific publications reflecting trends in scientific publications related to the energy transition of leading universities in Saudi Arabia. The universities were selected based on the presence of joint publications with the Saudi Arabian Oil Company, they are: King Fahd University of Petroleum and Minerals, King Abdullah University of Science and Technology, and King Saud University. The importance of studying the experience of Saudi Arabia for Russia in the context of the energy transition was highlighted. The analysis was based on Scopus platform data related to Subject Areas: Physical Sciences. Scientists from Saudi Arabian universities are increasingly publishing with co-authors from China, India, Egypt, Pakistan, and Malaysia, while maintaining high interaction with co-authors from the United States, South Korea, and the United Kingdom. Authors from the Russian Federation publish poorly with co-authors from Saudi Arabia. The trends in the topics of scientific publications were investigated, and their connection with the renewable energy topic was shown. The VOSviewer software was used to determine the main research areas using the cluster analysis method based on the co-occurrence of key terms. The analysis was done for both Author's keywords and Index keywords of the Scopus system. Graphical representation of the final choice of terms to describe research trends was proposed. TRANSLATE with x English ArabicHebrewPolish BulgarianHindiPortuguese CatalanHmong DawRomanian Chinese SimplifiedHungarianRussian Chinese TraditionalIndonesianSlovak CzechItalianSlovenian DanishJapaneseSpanish DutchKlingonSwedish EnglishKoreanThai EstonianLatvianTurkish FinnishLithuanianUkrainian FrenchMalayUrdu GermanMalteseVietnamese GreekNorwegianWelsh Haitian CreolePersian TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back

One of the key geophysical technologies for the energy industry during energy transition to zero footprint is fluid imaging. Knowledge of fluid distribution allows better, more optimized production reducing thus CO2 footprint per barrel produced and for CO2 storage the knowledge of where stored fluids go is mandatory to monitor reservoir seals. Electromagnetic is the preferred way to image fluid due to its strong coupling to the fluid resistivity. Unfortunately, acquiring and interpreting the data takes too long to contribute significantly to field operation and cost optimization. Using artificial intelligence and Cloud based data acquisition we can reduce the operational feedback to near real time and for the interpretation to close to 24 h. This then opens new door for the usefulness of this technology from exploration, monitoring and allows the application envelope to be enlarged to much noisier environment where real time acquisition can be optimized based on the acquired data.

Beyond the usual ferromagnetic and paramagnetic phases present in spin systems, the usual q-state clock model, presents an intermediate vortex state when the number of possible orientations q for the system is equal to 5 or larger. Such vortex states give rise to the Berezinskii-Kosterlitz-Thouless (BKT) phase present up to the XY model in the limit q→∞. Based on information theory, we present here an analysis of the classical order parameters plus new short-range parameters defined here. Thus, we show that even using the first nearest neighbors spin-spin correlations only, it is possible to distinguish the two transitions presented by this system for q greater than or equal to 5. Moreover, the appearance at relatively low temperature and disappearance of the BKT phase at a rather fix higher temperature is univocally determined by the short-range interactions recognized by the information content of classical and new parameters.

The evidence is presented for the long-range previtreous changes of two static properties: dielectric constant ( ) and its strong electric field related counterpart - the nonlinear dielectric effect (NDE). Notable is the evidence for the functional characterizations of (T) temperature changes by the ‘Mossotti Catastrophe’ formula, and NDE vs. T evolution by the relations resembling one developed for critical liquids. The analysis of dynamic properties based on the activation energy index excluded the Vogel-Fulcher-Tammann (VFT) relation as a validated tool for portraying the evolution of the primary relaxation time. Such a result questions the commonly applied ‘Stickel operator’ routine as the reliable tool for determining the dynamic crossover temperature. It is worth stressing that the strong electric field radically affects the distribution of relaxation times, the form of the evolution of the primary relaxation time as well as the fragility. Obtained results support the concept of a possible semi-continuous phase transition hidden below Tg. Studies were carried out in supercooled squalene, the material with extremely low electric conductivity, strongly elongated molecule, and vitally important for biology and medicine related issues.

Indonesia is an interesting case study for students of sustainable development and sustainable energy due to its ability to connect the multiple “worlds” it has become part of. Indonesia is an important bridge to Muslim countries, the voice of the Global South in the G20 and a main pillar of the 134-country-strong G77. Indonesia’s development trajectory is also key to the achievement of the Paris Climate Agreement as well as of the 2030 Agenda. Students can learn from how Indo-nesia address contradictions that would have been unsurmountable for other countries. Indone-sia’s energy transition offers helpful lessons, because of its aspiration to become a developed country by 2045. This goal is only possible when a country is able to effectively address barriers and caveats to sustainable energy. It is interesting how Indonesia focuses on silver linings and come up with pragmatic solutions to energy-related issues. This is followed by the “teaching guide,” which provides recommendations how the lessons from Indonesia can be embedded into a learning experience. The “learning activation approach” is introduced, which encourages stu-dents to systematically reflect on the complexity of selected contexts and understand this com-plexity by looking at the technical issues and processes that allow decision-making.

Particle layers employing conductive transition metal nitrides have been proposed as possible alternative plasmonic materials for photovoltaic applications due to their reduced losses compared to metal nanostructures. We critically compare the photocurrent gain due to an additional layer made of nanopillars of nitrides with other material classes obtained in an already highly optimized doped c-Si baseline solar cell with accurate doping profile from measurements. A relative photocurrent gain with respect to the baseline cell of on average 5% to 10% is observed, with a few cases achieving around 30% gain. While the local field enhancement is moderate resonances for nitrides spread over the whole UV-VIS range. For some nitrides, the shading effect remains a problem similar as for metals, but others behave more like dielectric scatterers with high photocurrent gain.

There is considerable interest in delineating the molecular mechanisms of action of transforming growth factor-β (TGF-β), considered as central player in a plethora of human conditions, including cancer, fibrosis and autoimmune disease. TGF-β elicits its biological effects through membrane bound serine/threonine kinase receptors which transmit their signals via downstream signalling molecules, SMADs, which regulate the transcription of target genes in collaboration with various co-activators and co-repressors. Until now, therapeutic strategy for primary Sjӧgren’s syndrome (pSS) has been focused on inflammation, but, recently, the involvement of TGF-β/SMADs signalling has been demonstrated in pSS, although TGFβ family members seems to have ambiguous effects on the function of pSS salivary glands. Based on these premises, this review highlights recent advances in unravelling the molecular basis for the multi-faceted functions of TGF-β in pSS that are dictated by orchestrations of SMADs, and describe TGF-β/SMADs value as both disease markers and/or therapeutic target for pSS.

：Sleep stage on the whole night is not steady. Sleepers generally pass through three to five cycles. In each cycle, there are occur four typical sleep stages, such as wake stage (WS), light stage (LS), deep sleep (DS), rapid eye movement sleep stage (REM). According to the natural routine, in this paper, we investigate the stage transition and analyze the feature of stage transition using the local cluster Algorithm (LCA). Two-cycle sleep model (TCSM) is proposed to automatically classify sleep stages using over-night continuous heart rate variability (HRV) data. The generated model is based on the characteristics of the nested cycle's sleep stage distribution and the transition probabilities of sleep stages. Experiments were conducted using a public data set including 400 healthy subjects (female 239, male 161) and the model’s classification accuracy was evaluated for four sleep stages: WS, LS, DS, REM. The experimental results showed that based on the TCSM model, the segmentation classification of pure sleep is 5.2% higher than that of the traditional method, and the accuracy of segmentation classification is 11.2% higher than the traditional sleep staging accuracy. The experimental performance is promising in terms of the accuracy, sensitivity, and specificity rates compared with the ones of the state-of-the-art methods. The study contributes to improve the quality of sleep monitoring in daily life using easy-to-wear HRV sensors.

Reliable information on transition matrix elements of various property operators between molecular electronic states is of crucial importance for predicting spectroscopic, electric, magnetic and radiative properties of molecules. The finite-field technique is a simple and rather accurate tool for evaluating transition matrix elements of first-order properties in the frames of the Fock space relativistic coupled cluster approach. We formulate and discuss the extension of this technique to the case of transitions between the electronic states associated with different sectors of the Fock space. Pilot applications to the evaluation of transition dipole moments between the closed-shell-like states (vacuum sector) and those dominated by single excitations of the Fermi vacuum (the $1h1p$ sector) in heavy atoms (Xe, Hg) and simple molecules of heavy element compounds (I${}_2$, TlF) are reported.

Phenotypic switching in cancer cells has been found to be present across tumor types. Recent studies on Glioblastoma report a remarkably common architecture of four well-defined phenotypes coexisting within high levels of intra-tumour genetic heterogeneity. Tumours grown from any cell type recapitulate the original phenotypic composition. Similar dynamics have been shown to occur in breast cancer, melanoma and likely across further cancer types. Given the adaptive potential of phenotypic switching (PHS) strategies, understanding how it drives tumour evolution and how to break down these architectures is a major priority. Here we model the ecological dynamics behind PHS. The model is able to reproduce experimental results, and specific conditions for cancer progression and clearance reveal novel features of plastic tumours and its direct consequences on therapy resistance. Following our results we discuss \textit{transition} therapy as a novel scheme to target not only combined cytotoxicity but also the rates of phenotypic switching.

The measures for tackling the COVID-19 may shrink the global GDP by approximately 6% in 2020, the deepest post-war recession. As a result, the global energy demand declined by 3.8% in the first quarter of 2020. Concerning fossil fuels, this conjuncture reduced the demand drastically and collapsed the prices to historic levels. Despite the general market disruptions, renewable energy sources (RES) seem to be more resilient to the crisis because they are the only sources that will grow in demand in 2020, driven by priority dispatch. The RES´s significant growth in cumulative installed capacity in the last two decades and the significant cost reductions of RES and energy storage technologies are positive signs towards better market conditions for the global energy transition. Currently, the crisis is seen by international agencies and transition scholars as an opportunity to advance a renewable-based energy transformation. Nevertheless, this article aims at caution about another possibility: if societal changes are not urgently implemented, the crisis may weaken the global energy transition. This article examines this last possibility from a three-level perspective: 1) post-COVID economic recovery, 2) low oil and natural gas prices and competitiveness of alternative sources and, 3) reorganization of the world energy market and the OPEC+. This paper exists to stimulate debate.

Forests across the world stand at the crossroad with climate and land use changes shaping their future. Despite the demonstration of political will and global efforts, forest loss, fragmentation and land degradation continue unabated. No clear evidence exists that these initiatives are working. Why are policies designed to halt deforestation and increase restoration of forest landscapes failing? A key reason for this apparent ineffectiveness lies in the failure to recognize the agency of the stakeholders involved and the adaptive capacities of the systems we seek to steer. Landscapes do not happen. We make them. They are the result of the sum of individual actions and decisions made by all stakeholders, and the interactions between these and biophysical processes. Likewise, forest transitions are not ecological, but social and behavioral. They are a product of the way humans manage ecosystems. Decision-makers need to integrate better representations of people’s agency in their mental models. We suggest possible solution pathways to overcome this key current barrier. These involve eliciting mental models behind policy decision, changing perspectives to better understand divergent points of view and refining strategies through explicit theories of change. Games designed to represent the constraints and opportunities that exist in the landscapes can help decision makers in these task.

Despite the long and extensive history of 3D technology, it has recently attracted the attention of researchers. This technology has become the center of interest of young people because of the real feelings and sensations it creates. People see their environment as 3D because of their eye structure. In this study, it is hypothesized that people lose their perception of depth during sleepy moments and that there is a sudden transition from 3D vision to 2D vision. Regarding these transitions, the EEG signal analysis method was used for deep and comprehensive analysis of 2D and 3D brain signals. In this study, a single-stream anaglyph video of random 2D and 3D segments was prepared. After watching this single video, the obtained EEG recordings were considered for two different analyses: the part involving the critical transition (transition-state) and the state analysis of only the 2D versus 3D or 3D versus 2D parts (steady-state). The main objective of this study is to see the behavioral changes of brain signals in 2D and 3D transitions. To clarify the impacts of the human brain’s power spectral density (PSD) in 2D-to-3D (2D_3D) and 3D-to-2D (3D_2D) transitions of anaglyph video, 9 visual healthy individuals were prepared for testing in this pioneering study. Spectrogram graphs based on Short Time Fourier transform (STFT) were considered to evaluate the power spectrum analysis in each EEG channel of transition or steady-state. Thus, in 2D and 3D transition scenarios, important channels representing EEG frequency bands and brain lobes will be identified. To classify the 2D and 3D transitions, the dominant bands and time intervals representing the maximum difference of PSD were selected. Afterward, effective features were selected by applying statistical methods such as standard deviation (SD), maximum (max), and Hjorth parameters to epochs indicating transition intervals. Ultimately, k-Nearest Neighbors (k-NN), Support Vector Machine (SVM), and Linear Discriminant Analysis (LDA) algorithms were applied to classify 2D_3D and 3D_2D transitions. The frontal, temporal, and partially parietal lobes show 2D_3D and 3D_2D transitions with a good classification success rate. Overall, it was found that Hjorth parameters and LDA algorithms have 71.11% and 77.78% classification success rates for transition and steady-state, respectively.

In this study, a parameter of volume stability was proposed for the first time to design polymorph zirconia ceramics used for special components. A series of heterogeneous polymorph zirconia ceramics with various amounts of monoclinic (M) phase were fabricated by two-step sintering. Samples with about 27%, 31%, and 51% M phase content were selected to study the properties. The thermal shock durability was found to be associated with thermal expansion behavior and noncritical micro cracks, which both based on M phase initial content. In good agreement with experimental results, the correlation of normalized K versus M phase initial content was established. It could provide a repeatable reference to prepare special zirconia components without loss of density.

Water splitting plays an important role in electrochemical and photoelectrochemical conversion of energy devices. Electrochemical water splitting by the hydrogen evolution reaction (HER) is a straightforward route to produce hydrogen (H2), which requires an efficient electrocatalysts to minimize energy consumption. Recent advances have created a rapid rise in new electrocatalysts, particularly those based on non-precious metals. In this review, we present a comprehensive overview of the recent developments of ternary and quaternary 6d-group transition metal chalcogenides (TMCs) based electrocatalysts for water splitting, especially for HER. Detailed discussion is organized from binary to quaternary TMCs including, surface engineering, heterostructures, chalcogen substitutions, and hierarchically structural design in TMCs. Moreover, emphasis is placed on future research scope and important challenges facing these electrocatalysts for further development in their performance towards water splitting.

The unsustainability of the services related to water, sanitation and hygiene in informal settlements in Sub-Saharan Africa services is deeply embedded in current societal and governance structures, cultures and practices; it is context-dependent and involves numerous actors with different interests. The field of sustainability transitions research addresses such persistent and large scale societal challenges, with transition management being one of its widely applied governance approach. By drawing on an analysis of the root causes of unsustainability and unreliability of WASH services in three case studies in Sub-Saharan Africa (Arusha-Tanzania, Dodowa-Ghana, Kampala-Uganda), we explore how a transition management approach can be designed to support a transition towards sustainable Water, Sanitation and Hygiene (WASH) in Sub-Saharan Africa. We distinguish the following contextual dimensions related to the unsustainability of WASH services: a) Multiplicity of WASH practices, structures and arrangements, b) Governance capacities for WASH services and maintenance, c) Landownership for sustainable access to WASH, d) Public participation in decision-making related to WASH, e) socio-economic structures governing access to WASH. These dimensions prompt the identification of conceptual and application challenges for transition management. Based on these challenges, recommendations were formulated for the design of a prescriptive transition management process that is not only functional but also emancipatory of character.

In our previous works we have proposed design equations that can predict with reasonable accuracy the transition point from homogeneous to heterogeneous regime as well as the gas holdup and the mean Sauter diameter at the homogeneous regime. The validity of the proposed correlations was checked with data obtained using different geometrical configurations and several Newtonian and non-Newtonian liquids as well as the addition of surfactants. However, in all the experiments the gas phase was atmospheric air. This work investigates the effect of gas phase properties by conducting experiments employing various gases (i.e., air, CO₂, He) that cover a wide range of physical property values. Experiments revealed that only the use of low-density gas (He) has a measurable effect on bubble column performance. More precisely, when the low-density gas (He) is employed, the transition point shifts to higher gas flow rates and the gas holdup decreases, a fact attributed to the lower momentum force exerted by the gas. In view of the new data, the proposed correlations have been slightly modified to include the effect of gas phase properties and it is found that they can predict the aforementioned quantities with an accuracy of ±15%. It has been also proved that CFD simulations are an accurate means for assessing the flow characteristics inside a bubble column.

Two novel inorganic–organic hybrid supramolecular assemblies, namely, (4-HNA)(18-crown-6)(HSO₄) (1) and (4-HNA)₂(18-crown-6)₂(PF₆)₂(CH₃OH) (2) (4-HNA = 4-nitroanilinium), were synthesized and characterized by infrared spectroscopy, single X-ray diffraction, differential scanning calorimetry (DSC), and temperature-dependent dielectric measurements. The two compounds underwent reversible phase transitions at about 255 K and 265 K, respectively. These phase transitions were revealed and confirmed by the thermal anomalies in DSC measurements and abrupt dielectric anomalies during heating. The phase transition may have originated from the [(4-HNA)(18-crown-6)]⁺ supramolecular cation. The inorganic anions tuned the crystal packings and thus influenced the phase-transition points and types. The variable-temperature X-ray diffraction data for crystal 1 revealed the occurrence of a phase transition in the high-temperature phase with the space group of P2₁/c and in the low-temperature phase with the space group of P2₁/n. Crystal 2 exhibited the same space group P2₁/c at different temperatures. The results indicated that crystals 1 and 2 both underwent an iso-structural phase transition.

Migraine is a common condition that affects children as they develop into adults. Transition of care from pediatric to adult care has becoming an increasingly popular topic in the medical literature. It has been suggested that discussions between patients, their families and providers should be initiated as early as age 13. Patients who are un or underprepared have poorer outcomes due to increased morbidity and worsening of their medical condition. Many children continue to have migraine into adulthood and if efforts are taken to ensure patients receive appropriate transfer of care, the results can significantly decrease the economic burden of this disease.

The intention of this paper is to elucidate new types of heat engines with extraordinary efficiency, more specifically to eventually focus on the author’s research into a temporary magnetic remanence device. First we extend the definition of heat engines through a diagrammatic classification scheme and note a paradoxical non-coincidence between the Carnot, Kelvin-Planck and other forms of the 2nd Law, between sectors of the diagram. It is then seen, between the diagram sectors, how super-efficient heat engines are able to reduce the degrees of freedom resulting from change in chemical potential, over mere generation of heat; until in the right sector of the diagram, the conventional wisdom for the need of two reservoirs is refuted. A brief survey of the Maxwell Demon problem finds no problem with information theoretic constructs. Our ongoing experimental enquiry into a temporary magnetic remanence cycle using standard kinetic theory, thermodynamics and electrodynamics is presented – yet a contradiction results with the 2nd law placing it in the right sector of the classification diagram.

In this study, we considered the structural stability, electronic properties, and phonon dispersion of the cubic (c-ZrO₂), tetragonal (t-ZrO₂), and monoclinic (m-ZrO₂) phases of ZrO₂. We found that the monoclinic phase of zirconium dioxide is the most stable among the three phases in terms of total energy, lowest enthalpy, highest entropy, and other thermodynamic properties. The smallest negative modes were found for m-ZrO₂. Our analysis of the electronic properties showed that during the m–t phase transformation of ZrO₂, the Fermi level first shifts by 0.125 eV toward higher energies and then decreases by 0.08 eV in the t–c cross-section. The band gaps for c-ZrO₂, t-ZrO₂, and m-ZrO₂ are 5.140 eV, 5.898 eV, and 5.288 eV, respectively. Calculations based on the analysis of the influence of doping 3.23, 6.67, 10.35, and 16.15 mol. %Y₂O₃ onto the m-ZrO₂ structure showed that the enthalpy of m-YSZ decreases linearly, which accompanies further stabilization of monoclinic ZrO₂ and an increase in its defectiveness. The doping-induced and concentration-dependent phase transition of zirconium dioxide under the influence of yttrium oxide was studied, after which the position of the Fermi level changes and the energy gap decreases. It has been established that, not only for pure systems but including those doped with Y₂O₃, the main contribution to the formation of the conduction band is made by the p-states of electrons. The t-ZrO₂ (101) and t-YSZ (101) surface models were selected as optimal surfaces for water adsorption based on a comparison of their surface energies. An analysis of the mechanism of water adsorption on the surface of t-ZrO₂ (101) and t-YSZ (101) showed that H₂O on unstabilized t-ZrO₂ (101) is adsorbed dissociatively with an energy of -1.22 eV, as well as by the method of molecular chemisorption with an energy of -0.69 eV and the formation of a hydrogen bond with a bond length of 1.01 Å. In the case of t-YSZ (101), water is molecularly adsorbed onto the surface with an energy of -1.84 eV. Dissociative adsorption of water occurs at an energy of -1.23 eV, near the yttrium atom. The calculations showed that ab initio research methods are capable of describing the mechanism of phase transitions of materials under the influence of alloying. That is, by optimizing the parameters of DFT calculations, it is possible to observe the effects of doping on other physical and chemical properties of materials, which are still beyond the scope of quantum chemical modeling. The obtained results complement the database of research works carried out in the field of the application of biocompatible zirconium dioxide crystals and ceramics in green energy generation and can be used in designing humidity-to-electricity converters and creating solid oxide fuel cells based on ZrO₂.

The corona (COVID-19) pandemic offers an opportunity for dealing with persistent problems, through a transformative recovery process. It is a crisis that offers opportunities for dealing with three interrelated crises: the ecological crisis (climate change, loss of biodiversity, resource depletion, pollution and ecosystem destruction), the confidence crisis (people losing trust in government, politics, companies, regular news channels, science, each other and the future), and the inequality crisis (the widening of the gap between rich and poor). Our argument is that sustainability transitions will not succeed without a different economy and another social contract with the associated rights and duties of care (for the environment and the well-being of others, including future generations). A different social contract is not only desirable from the point of view of sustainability and fairness, justice and equality, but is also necessary to restore citizens' trust in politics, government, companies and each other. In the paper we discuss mechanisms towards a Natural Social Contract, systemic leverage points for system transformations and possibilities for co-evolutionary governance by actor coalitions interested in transformative change. The combination of those three elements helps to synchronize different agendas and reduce the chance that they will work against each other.

The article delves into the intricate phase transitions of 1-Octadecanol and n-Nonadecane within a binary system, unveiling dynamic structural changes under varying conditions. Through Fouri-er-transform infrared (FTIR) analysis, specific molecular vibrations were identified, shedding light on the molecular composition and interactions. The study highlights the challenges in detecting subtle phase transitions and emphasizes the individuality of molecular behaviours in closely related compounds. The findings underscore the complexity of phase transitions in binary systems and advocate for a nuanced approach to studying molecular structures and behaviours. Addi-tionally, the research contributes valuable insights into the molecular dynamics of Organic Polymer Functional Adsorption Materials, offering implications for synthetic waxy layers in plant epidermis.

This study presents the synthesis and electrochemical evaluation of nitrogen-doped vanadium oxide (N-V2O3/C) as a cathode material for aqueous zinc-ion batteries (AZIBs), using a hydrothermal method. Compared to undoped V2O3/C, N-V2O3/C exhibits enhanced electrical conductivity, capacity, and electrochemical kinetics, attributed to the incorporation of pyridinic and pyrrolic nitrogen. Initial charge-discharge cycles indicate phase transitions to amorphous vanadium oxides, enhancing conductivity. N-V2O3/C shows a high specific capacity of 168.4 mAh g−1 at 10 A g−1 and remarkable reversibility, highlighted by the transient existence of intermediate species during cycling. Optimal electrochemical performance is achieved with a vanadium to nitrogen molar ratio of 2:3, indicating the significant impact of nitrogen doping concentration on the material’s efficiency. This work underscores the potential of N-V2O3/C as a superior cathode material for AZIBs.

Abstract Objective Variations of sex characteristics (VSC) are atypical genetic, hormonal, gonadal and anatomical sex traits that require holistic medical management. The Chicago Consensus statement 2006 introduced the requirement that multidisciplinary teams organise the transition of care from pediatric to adult services. Yet, the evidence that the transitional care is in place is scarce. The aim of this paper is to examine the implementation of transition of care for people with VSC. Method Seven focus groups were conducted with health care professionals and peer support groups in care teams in Central, Northern and Western Europe. The data from the focus groups were examined using reflexive thematic analysis. Results The participants in the study stated that the transition of care has been implemented in the last two decades. The quality of care depends on available resources and variation of sex characteristics. However, there are significant hurdles to adequate transition of care as there is lack of time and resources. Lack of adult care providers and psychosocial support leaves young adults and adults with VSC navigating the health care system often alone. Conclusion The outcome of the study shows that the transition of care is organized through the department of pediatric endocrinology. The quality of care varies due to resources and variation. Lack of adult specialists and psychosocial support represent the biggest obstacle for young adults and adults to navigate the healthcare system and for the improvement in provision of healthcare to adults, especially psychosocial support.

The current study primarily aimed to simulate detonation initiation via turbulent jet flame acceleration in partial-premixed H2-air mixtures. Different vertical concentration gradients were generated by varying the duration of hydrogen injection (referred to as diffusion time) within an enclosed channel filled with air. H2-air mixtures with average hydrogen concentrations of 22.5% (lean mixture) and 30% (near stoichiometric mixture) were investigated at diffusion times of 3, 5, and 60 seconds. Numerical results show that the vertical concentration gradient has a major influence on the early-stage of flame acceleration (FA). In the stratified lean mixture, detonation began in all the diffusion times, and comparing the flame-speed graphs showed that a decrease in the diffusion time and an increase in the mixture inhomogeneity speeded up the flame propagation and the jet flame to detonation transition occurrence in the channel. In the stratified H2-air mixture with an average hydrogen concentration of 30%, transition from a turbulent jet flame to detonation occurred in all the cases, and the mixture inhomogeneity weakened the FA and delayed the detonation initiation.

Oral cancer ranks sixth among Taiwan's top 10 cancers, and most patients with poor prognosis acquire metastases. The essential fatty acid alpha-linolenic acid (ALA) has been found to diminish many cancer properties. However, the anti-cancer activity of ALA in oral cancer has yet to be determined. Migration and invasion assays confirmed OSCC cells' EMT capabilities, whereas flow cytometry and Western blotting identified the molecular pathways. ALA dramatically reduced cell growth in a concentration dependent manner, according to the findings. Low concentrations of ALA (100 or 200 μM) inhibit colony formation, expression of Twist and EMT-related proteins, expression of MMP2/-9 proteins and enzyme activity, as well as cell migration and invasion. Treatment with high concentrations of ALA (200 or 400 μM) greatly increases JNK phosphorylation and c-jun nuclear accumulation, then upregulates the FasL/caspase8/caspase3 and Bid/cytochrome c/caspase9/caspase3 pathways, leading to cell death. Low concentrations of ALA inhibit SAS and GNM cell migration and invasion by suppressing Twist and downregulating EMT-related proteins, or by decreasing the protein expression and enzyme activity of MMP-2/-9, whereas high concentrations of ALA promote apoptosis by activating the JNK/FasL/caspase 8/caspase 3-extrinsic pathway and the Bid/cytochrome c/caspase 9 pathway. ALA demonstrates potential as a treatment for OSCC patients.

The article aims to explore social aspects in the area of energy research by using bibliometrics methods and tools. The study is based on the data of Energy Research & Social Science journal publications exported from ScienceDirect database during 2019-2023. Methodologically, the work included clustering of the bibliometric records under consideration. This allowed to identify the main topics of publications and those in which the research of social problems prevails. This stage of the work was carried out using carrot2, an engine for clustering search results. Next, the analysis of publication topics related to social issues research was carried out using VOSviewer — a software tool for visualizing scientific landscapes. The topics of the four clusters obtained at this stage were described by key terms with the maximum total link strength. For the principal ones, a definition was made on the basis of the texts of publications that most fully disclose the meaning of these terms. The 1537 publications in the journal during the period under review deal with many aspects of energy transition research, renewable energy, energy policy, energy justice and energy systems, but only 78 of them are dominated by social issues. The paper reveals the main social issues in the field of energy research: sociology of energy, socio-technical system, community energy, energy democracy, sociology of the future, energy sovereignty, socio-technical imaginary and shows the insufficient attention to this topic, especially to the investment of such research.

Due to its economic benefits and the ability to reduce carbon emissions on a large scale, the CCUS-EOR project has been widely promoted and implemented globally. By using carbon dioxide flooding, oil water transition zone reservoirs that were once considered worthless may have new potential for development because of its rich geological reserves and high quality carbon sequestration conditions. Unlike water flooded layer, the oil in the TZ is unsaturated rather than residual oil after water flooding, which would lead to special oil-water seepage law of initial oil saturation. It is necessary to clarify special oil-water seepage law of oil-water transition zone to evaluate its production & storage potential. In this paper, we present a series of experiments to characterize the relationship between residual oil saturation and initial oil saturation. Cores in four different permeability and oil in four different viscosity are used to simulate different reservoir conditions, and that CO2 immiscible flooding experiments for each cores permeability and oil viscosity are performed with four different initial oil saturation. A total of 36 sets of CO2 flooding experiment data are used to draw the initial oil saturation & residual oil saturation chart. The results show that the residual oil saturation depends on the initial oil saturation rather than constant under certain conditions of core and oil. Under the condition of low permeability and high oil viscosity, the influence of initial oil saturation on residual oil saturation is relatively strong. The initial oil saturation & residual oil saturation chart can accurately calculate the residual oil saturation, initial water cut and final recovery based on the core permeability, oil viscosity and the initial oil saturation which is the first time to put forward this kind of chart and of the great significance to evaluate the recovery potential of the TZ.

The cubic nonlinearity of graphene oxide (GO) monolayer was characterized by open and closed Z-scan using a nano-second laser of 10 Hz repetition rate with a Gaussian spatial beam profile. The reverse saturable absorption or positive nonlinearity from open Z-scan and valley-peak traces or positive nonlinearity from closed Z-scan was displayed. The reverse saturable absorption could be from a two-photon or two-step excitation process due to the larger absorption in the lower visible and upper UV wavelength region compared with the excitation source. The nonlinear absorption and nonlinear refraction coefficient were estimated to be ~ 2.62x10-8 m/W and 3.9x10-15 m2/W, respectively. This study also reveals the effect of nonlinear absorption on nonlinear refraction traces.

Background: Ovarian cancer is the leading cause of death from gynecological malignancies with serous carcinoma being the most common histopathologic subtype. Epithelial-Mesenchymal Transition (EMT) correlates with an increased metastatic potential, whereas the transcription factor SOX11 is overexpressed in diverse malignancies. Methods: In the present study, we aim to evaluate the potential role of the immunohistochemical expression of SOX11 in 30 serous ovarian carcinomas in association with E-cadherin and Vimentin expression as well as with patients’ clinicopathological data. Results: Most of the examined cases showed concurrent expression of E-cadherin and Vimentin, whereas SOX11 was expressed in a minority of the cases (26,7%). Interestingly, the positive cases had more frequently a metastatic disease at the time of diagnosis compared to the negative cases (p=0.09), an association, however, of marginal significance. Moreover, there was a negative correlation between E-Cadherin and SOX11 expression (p=0,0077) and a positive correlation between Vimentin and SOX11 expression (p=0,0130). Conclusions: The present work, for the first time, provides preliminary evidence SOX11 overexpression alongside E-cadherin loss in the promotion of EMT in serous ovarian cancer, thereby endorsing tumor metastasis.

Digitalization technologies have been identified as enablers for the adoption of Circular Economy practices. The machinery value chain, addressed in this study, is affected by the introduction of digital technologies that enable real-time monitoring data on product condition and control optimization deploying predictive analytics techniques, as well as the offerings of circular-based services. Machinery lifetime extension can be digitally enabled on both old and new machines. The research objectives were to investigate how digital technologies enable the adoption of circular economy-based business models in manufacturing companies and provide an answer about i) what Life Cycle Extension Strategy is suitable for digital circular business model adoption and ii) how digitalization of machines enables manufacturing companies to innovate their business model. The correlation matrix is the tool developed from the proposed approach; it aims at supporting manufacturers in the very first contact with circular business models. In the context of the European RECLAIM project, two manufacturers apply the approach, proving its validity and wide applicability. The next steps are expected to introduce quantitative indicators to define thresholds for the steps toward circularity, without replacing the qualitative approach, as it guarantees the wide applicability of the approach in context that never considered circularity yet.

Lipopolysaccharides are a type of polysaccharide mainly present in the bacterial outer membrane of Gram-negative bacteria. Recent studies have revealed that lipopolysaccharides contribute to the immune response of the host by functioning as a cancer antigen. We retrospectively recruited 198 patients with gastric cancer who underwent surgery. The presence of lipopolysaccharides was determined using immunohistochemical staining, with the intensity score indicating positivity. The relationship between lipopolysaccharides and CD8, PD-L1, TGFBI (a representative downstream gene of TGF-β signaling), E-cadherin, and claudin-4 (epithelial–mesenchymal transition markers) was also investigated. Thereafter, we identified 20 patients with advanced gastric cancer receiving nivolumab and investigated the relationship between lipopolysaccharides and nivolumab sensitivity. After staining for lipopolysaccharides in the nucleus of cancer cells, 150 negative (75.8%) and 48 positive cases (24.2%) were found. The lipopolysaccharide-positive group showed increased cancer stromal TGFBI expression (p < 0.0001) and PD-L1 expression in cancer cells (p = 0.0029). Lipopolysaccharide positivity was significantly correlated with decreased E-cadherin expression (p = 0.0055) and claudin-4 expression (p = 0.029); however, no significant correlation was found between lipopolysaccharide expression and overall survival rate (p = 0.71). Among cases receiving nivolumab, the lipopolysaccharide-negative and -positive groups had a disease control rate of 66.7% and 11.8%, respectively (p = 0.049). Lipopolysaccharide positivity was associated with TGF-β signaling and epithelial–mesenchymal transition and was considered to promote therapeutic resistance to nivolumab.

Silver iodide (AgI) is a system prototype allowing the flow of ions through its structure and has a phase transition at 420 K, characterized by an abrupt change in conductivity and a high ionic conductivity. Introducing low concentrations of graphite (C) into the AgI structure produces a new material with a mixed conductivity (ionic and electronic) which increases with increasing temperature. The experimental results of the logarithm of the ionic conductivity as a function of the inverse of temperature for the (AgI)x–C(1−x) system for low carbon concentrations 0.97 ≤ x ≤ 0.99 were well fitted using a phenomenological model with a probability distribution for the charge carriers based on the carrier density

State transition in the multiple-levels system has the great potential applications in the quantum technology. In this article we employ a deterministic approach in complex space to analyze the dynamics of the 1s-2p electron transition in the hydrogen atom. The electron’s spin motion is embodied in the framework of quantum Hamilton mechanics that allows us to examine the transition dynamics more precisely. The transition is driven by an oscillating electric field in the z-direction. The electron’s transition process can be visualized by monitoring its motion in the complex space. The quantum potential and the total energy proposed in this paper provide new indices to observe the dynamic changes of electrons in the transition process.

All living organisms require some metal ions for their energy production as well as metabolic and biosynthetic processes. Within cells, metal ions are involved in the formation of adducts interact with metabolites and macromolecules (proteins and nucleic acids). The proteins that require binding to one or more metal ions to be able to carry out their physiological function are called metalloproteins. About one third of all protein structures in the Protein Data Bank involve metalloproteins. Over the past few years there has been a tremendous progress in the number of computational tools and techniques making use of 3D structural information to support the investigation of metalloproteins. This trend has been boosted also by the successful applications of neural networks and deep learning approaches in molecular and structural biology at large. In this review, we discuss recent advances in the development and availability of resources dealing with metalloproteins from a structure-based perspective. We start by addressing tools for the prediction of metal-binding sites (MBSs) using structural information on apo-proteins. Then, we provide an overview of methods for and lessons learned from the structural comparison of MBSs in a fold-independent manner. We then move to describing databases of metalloprotein/MBS structures. Finally, we summarize recent DL applications enhancing the functional interpretation of metalloprotein structures.

Intending to analyze the role of nuclear power in an integrated energy system, we used the IESA-Opt-N cost minimization model focusing on four key themes: system-wide impacts of nuclear power, uncertain technological costs, flexible generation, and cross-border electricity trade. We demonstrate that the Levelized Cost of Energy (LCOE) alone should not be used to demonstrate the economic feasibility of a power generation technology. For instance, under the default techno-economic assumptions, particularly the 5% discount rate and exogenous electricity trade potentials, it is cost-optimal for the Netherlands to invest in 9.6 GWe nuclear capacity by 2050. However, its LCOE is 34 €/MWh higher than offshore wind. Moreover, we found that nuclear power investments can reduce demand for variable renewable energy sources in the short term and higher energy independence (i.e., lower imports of natural gas, biomass, and electricity) in the long term. Furthermore, investing in nuclear power can reduce the mitigation costs of the Dutch energy system by 1.6% and 6.2% in 2040 and 2050, and 25% lower national CO₂ prices by 2050. However, this cost reduction is not significant given the odds of higher nuclear financing costs and longer construction times. In addition, this study has shown that lower financing costs (e.g., EU taxonomy support) considerably reduce the relevance of nuclear cost uncertainties on its investments. Furthermore, we demonstrate that the economic feasibility of national nuclear power investments can vary considerably depending on the cross-border electricity trade assumptions. Additionally, we found that lowering the cost of small modular reactors has more impact on their economic feasibility than increasing their generation flexibility. In conclusion, under the specific assumptions of this study, nuclear power can play a complementary role (in parallel to the wind and solar power) in supporting the Dutch energy transition from the sole techno-economic point of view.

I wish to suggest a physiological function for alpha-synuclein (a-syn) that has the potential to explain its role in pathology. Intraneuronal proteinaceous Lewy Bodies (LBs), the pathological hallmark of Parkinson’s disease and other synucleinopathies, consist majorly of a-syn. Ample evidence suggests that LBs are not the result of simple amyloidosis of cytosolic a-syn. Benign soluble unstructured a-syn gets converted into toxic species which preferentially accumulates in LBs. But how these aberrant a-syn molecules are produced in the cytosol, is still not clear. The present hypothesis is an effort to relate a metabolic reaction specific to neuronal function, that is, phase transition, with the pathobiology of a-syn. During high frequency stimulation, which entails rapid phase transition reactions at the presynaptic compartment, aberrant interaction of a-syn with the membrane occasionally generates toxic a-syn molecules. My conjecture is that the physiological function of a-syn is to modulate membrane fluidity by a process wherein it goes through a conformation cycle driven by a flux of energy from mitochondria. It is the range of toxic a-syn produced during aberrant phase transition reaction that is responsible for pathology, not the normal a-syn that reenters the conformation cycle, thereby, resolving the paradox of the Janus-face of a-syn.

Existing Reynolds Averaged Navier-Stokes based transition models do not accurately predict separation induced transition for low pressure turbines. Therefore, in this study, a novel framework based on computational fluids dynamics driven machine learning coupled with multi-expression and multi-objective optimization is explored to develop models which can improve the transition prediction for the T106A low pressure turbine at an isentropic exit Reynolds number of Re2is=100,000. Model formulations are proposed for the transfer and laminar eddy viscosity terms of the laminar kinetic energy transition model using seven non-dimensional pi groups. The multi-objective optimization approach makes use of cost functions based on the suction-side wall-shear stress and the pressure coefficient. A family of solutions is thus developed, whose performance is assessed using Pareto analysis and in terms of physical characteristics of separated-flow transition. Two models are found which bring the wall-shear stress profile in the separated region at least two times closer to the reference high-fidelity data than the baseline transition model. As these models are able to accurately predict the flow coming off the blade trailing edge, they are also able to significantly enhance the wake-mixing prediction over the baseline model.

The liquid droplet cooling technique for fast scanning chip calorimetry (FSC) is introduced, increasing the cooling rate for large samples on a given sensor. Reaching higher cooling rates and using a gas as the cooling medium, the common standard for ultra-fast temperature control in cooling, requires reducing the lateral dimensions of the sample and sensor. The maximum cooling rate is limited by the heat capacity of the sample and the heat exchange between the gas and the sample. The enhanced cooling performance of the new liquid droplet cooling technique is demonstrated for both metals and polymers, on examples of solidification of large samples of indium, high-density polyethylene (HDPE), and poly (butylene 2,6-naphthalate) (PBN). It was found that the maximum cooling rate can be increased up to 5 MK/s in room temperature environment, that is, by 2 orders of magnitude, compared to standard gas cooling. Furthermore, modifying the droplet size and using coolants at different temperatures provide options to adjust the cooling rate in the temperature ranges of interest.

We study the hadron-quark hybrid equation of state (EOS) of compact-star matter. The Nambu—Jona-Lasinio (NJL) local SU(3) model with vector-type interaction is used to describe the quark matter phase, while the relativistic mean field (RMF) theory with scalar-isovector $\delta$-meson effective field adopted to describe the hadronic matter phase. It is shown that the larger the vector coupling constant, the lower the threshold density for the appearance of strange quarks. For a sufficiently small value of the vector coupling constant, the functions of the mass dependence on the baryonic chemical potential have regions of ambiguity which leads to a phase transition in non-strange quark matter with an abrupt change in the baryon number density. We show that within the framework of the NJL model, the hypothesis on the absolute stability of strange quark matter is not realized. In order to describe the phase transition from hadronic matter to quark matter, the Maxwell's construction is applied. It is shown that the greater the vector coupling, the greater the stiffness of the EOS for quark matter and the phase transition pressure. Our results indicate that the infinitesimal core of the quark phase, formed in the center of the neutron star, is stable.

In the application of classical nucleation theory (CNT) and all other theoretical models of crystallization of liquids and glasses it is always assumed that nucleation proceeds only after the supercooled liquid or the glass have completed structural relaxation processes towards the metastable equilibrium state. Only employing such assumption, the thermodynamic driving force of crystallization and the surface tension can be determined in the way it is commonly performed. The present paper is devoted to the theoretical treatment of a different situation when nucleation proceeds concomitantly with structural relaxation. To treat the nucleation kinetics theoretically for such cases, we need adequate expressions for the thermodynamic driving force and the surface tension accounting for the contributions caused by the deviation of the supercooled liquid from metastable equilibrium. In the present paper, such relations are derived. They are expressed via deviations of structural order parameters from their equilibrium values. Relaxation processes result in changes of the structural order parameters with time. As a consequence, the thermodynamic driving force and surface tension, and basic characteristics of crystal nucleation, such as the work of critical cluster formation and the steady-state nucleation rate, also become time-dependent. We show that this scenario may be realized in the vicinity and below the glass transition temperature, and it may occur only if diffusion (controlling nucleation) and viscosity (controlling the alpha-relaxation process) in the liquid decouple. Analytical estimates are illustrated and confirmed by numerical computations for a model system. The theory is successfully applied to the interpretation of experimental data. Several further consequences of this newly developed theoretical treatment are discussed in detail. In line with our previous investigations, we reconfirm that only when the characteristic times of structural relaxation are of similar order of magnitude or longer than the characteristic times of crystal nucleation, elastic stresses evolving in nucleation may significantly affect this process. Completing the analysis of elastic stress effects, for the first time expressions are derived for the dependence of the surface tension of critical crystallites on elastic stresses. As the result, a comprehensive theoretical description of crystal nucleation accounting appropriately for the effects of deviations of the liquid from the metastable states and of relaxation on crystal nucleation of glass-forming liquids, including the effect of simultaneous stress evolution and stress relaxation on nucleation, is now available. As one if its applications, this theoretical treatment provides a new tool for the explanation of the low-temperature anomaly in nucleation in silicate and polymer glasses (the so-called \breakdown" of CNT at temperatures below the temperature of the maximum steady-state nucleation rate). We show that this anomaly results from much more complex features of crystal nucleation in glasses caused by deviations from metastable equilibrium (resulting in changes of the thermodynamic driving force, the surface tension, and the work of critical cluster formation, in the necessity to account of structural relaxation and stress effects) than assumed so far.

The current energy policy recommends the idea of energy efficiency over fossil energy as a primary matter for the coming years. The kingdom of Morocco requires restructuring of its power equipment by increasing the percentage of renewable energy supplies, optimizing their systems and power storage. Therefore, increasing energy efficiency is an as important obligation as reducing the overall energy consumption. The purpose of this research is to present the energy transition in Morocco towards renewable energies and to assess the diversity of available marine natural resources. Recent research in conversion of ocean thermal energy, wave energy, tidal energy, offshore wind energy, and osmotic energy into power supply has started to encourage different technologies. This research has led to commercial deployment in some cases such as our 550 km long Mediterranean coast and 3000 km long Atlantic. This does not only result in fossil energies independency but also provides advantages like less cost and no pollution.

The welding performance of shipbuilding steel under large heat input could be improved greatly by the Mg addition to the steel, but the impact toughness of the HAZ is not stable. According to the three different thickness steel plates obtained in the industrial experiment, the large heat input welding was carried out by different heat input, and the impact toughness analysis, impact fracture analysis, metallographic microstructure analysis and inclusions analysis were carried out. The results showed that, the HAZ of three kinds of thickness plates induced a lot of IAF, with Mg addition, the inclusion dimension had been reduced effectively, and the IAF induced ability of the inclusions had also been improved. The difference of HAZ impact toughness with different welding heat input and different impact temperature is significant, in consideration of the influence of welding heat input and metallographic microstructure on impact toughness of HAZ, the welding heat load had far greater effect than metallographic microstructure on ductile-brittle transition temperature. At the same time, if the original metallographic microstructure of steel was coarse, the pinning effect of the inclusions would be reduced significantly, and the microstructure of HAZ would be coarsened and the impact toughness of HAZ would be decreased, so there is a certain matching relationship between the metallographic microstructure and the inclusion dimension.

The energy, momentum and the action associated with the time domain transition radiation fields are investigated. The results show that for a charged particle moving with speed $v$, the longitudinal momentum associated with the transition radiation is approximately equal to $E/c$ for values of $1-v/c$ smaller than about 10^-3 where $E$ is the total radiated energy and c is the speed of light in free space. The action of the transition radiation, defined as the product of the energy dissipated and the duration of the emission, increases as $1-v/c$ decreases and, for an electron, it becomes equal to $h/4\pi$ when $v=c-v_m$ where $v_m$ is the speed associated with the lowest energy state of a particle confined inside the universe and h is the Plank constant. Combining these results with Heisenberg’s uncertainty principle, an expression for the electronic charge based on other fundamental physical constants is derived. The best agreement between the experimentally observed electronic charge and the theoretical prediction is obtained when one assumes that the actual size of the universe is about 250 times larger than the visible universe.

Objective: Aims to investigate the effects of empagliflozin (EMPA), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, on renal fibrosis in male diabetic Sprague-Dawley (SD) rat model. Methods: Streptozotocin(STZ) were injected to establish diabetes model, EMPA (10 mg/kg·d) or normal saline (NS) were administered for four weeks. The changes in renal fibrosis-related biomarkers, include vimentin (VIM), collagen types I(Col-I), collagen types III(Col-III), fibroblast-specific protein 1(FSP-1), connective tissue growth factor (CTGF), fibronectin (FN) were evaluated. Renal pathology, serum glucose levels and urinary protein excretion were also assessed. Results: Biomarkers of renal fibrosis were significantly reduced in the EMPA group compared to those in the NS group after 4-week treatment, including VIM (519.84±83.37 vs. 663.27±91.84 ng/ml, P<0.05), Col-I (21.27±1.46 vs. 25.71±2.82 ng/ml , P<0.05) and Col-III (7.06±1.12 vs. 9.43±1.36 ng/ml, P<0.05), FSP-1 (4.38±0.81 vs. 5.70±0.78 ng/ml, P<0.05), and CTGF (1147±217 vs. 1556±235 pg/ml, P<0.05),respectively. Nevertheless, compared to normal control (NC) group, the levels of renal fibrosis-related biomarkers in the EMPA group showed no significant differences except for VIM, which was VIM (336.66±28.87 vs. 519.84±83.37 ng/mL, P<0.001). NS group rats showed notable renal tubular dilation and casts, EMPA group exhibited only mild tubular dilation. Conclusion: These findings suggest that empagliflozin reverse renal fibrosis potentially through inhibiting CTGF-mediated epithelial-mesenchymal transition.

Femtoscopy is a unique tool to investigate the space-time geometry of the matter created in ultra-relativistic collisions. If the probability density distribution of hadron emission is parametrized, then the dependence of its parameters on particle momentum, collision energy, and collision geometry can be given. In recent years, several measurements came to light that indicated the adequacy of assuming a Lévy-stable shape for the mentioned distribution. In parallel, several new phenomenological developments appeared, aiding the interpretation of the experimental results, or providing tools for the measurements. In this paper we review and discuss some of these advances, phenomenological and experimental.

In 2018, the state of Himachal Pradesh in north India launched an initiative to convert all its farmers to natural farming (NF), an agroecological approach. The aim was to address multiple challenges related to rural livelihoods, high input costs, biodiversity loss, and environmental degradation. This paper is based on a qualitative case study of the state programme to transition farmers to NF. It seeks to understand how its mechanisms support and empower small and marginal women farmers. In addition to identifying mechanisms that facilitate the effective uptake of NF, the case study sought women's views on whether these increased spaces for decision-making and developed capabilities and autonomy. Framed within the vision of reclaiming food sovereignty, various mechanisms such as training in villages, participating in NF groups and networks, visits to model farms and adopting leadership roles offered new pathways for women farmers to gain confidence and capabilities. Women began to participate in spaces that had been culturally and structurally denied to them. This case study illustrates how agroecology efforts with a specific focus on gender have the potential to provide women with creative outlets and a variety of decision-making and income-generating roles, spaces for community learning and knowledge needed for sustainable ecosystems.

This review focuses on the Just Energy Transition (JET) policies of the BRICS member countries, with the aim of finding lessons and possible adoption of some of the key energy policy aspects utilized in other countries for benchmarking for the South African context. Considerations of the present stage of JET in South Africa and the energy-source mix supporting the electricity sector, cognisant of the lifespan and condition of power plants. Analysis of the energy mix revealed that all nations were energy dependent on electricity which was produced by predominantly fossil fuelled power plants with high GHG (concentrating on high CO2 emissions). It was concluded that some of the learnings and lessons learnt from the BRICS countries might be incorporated into a South African energy plan for the transition with options and guidance for formulation of policies. This study will attract responsible environmentally conscious audience that has a commitment and drive to combat global warming and curbing climate change.

The intensification of conflicts associated with the use of water in the transition region of the Cerrado and Amazon biomes caused by population and economic growth, combined with the interest in generating energy from hydroelectric plants, raise the need to quantify the surface water availability of rivers contributing with different drainage areas. The present study estimated and compared loco measurements of liquid flow (QL) and depth of rivers in the Teles Pires river basin by reference methods (MLN-7 hydrometric windlass and metal rod/winch) and by Acoustic Current Profiler by Doppler Effect (ADCP RiverRay), in addition, evaluated the total measurement time underestimation uncertainty by ADCP. Field measurements were carried out at monthly intervals between March 2020 and October 2021, seeking to represent the water seasonality and depth and QL variations in the cross-sections of the Caiabi 1 and 2, Celeste, Preto and Renato rivers. The evaluated rivers had a net flow between 3.48 and 60.78 m3 s-1 by the windlass and between 2.66 and 54.30 m3 s-1 by the ADCP, while the depths obtained were from 0.17 to 6.34 m by the rod/winch and from 0.65 to 6.20 m by the ADCP. The methods resulted in similar measurements of net flow and depth in each of the cross-sections, and the statistical performance of the linear regression model was satisfactory with a Willmott concordance index of 0.9977 and 0.9819 for estimates of QL and of the depth of the cross-sections, respectively. The ADCP accurately measured net discharge and depth in shallow (up to 6.5 m) cross-sections of Teles Pires River in relative to the reference method. Determining the total measurement time and pairs of transects to obtain accurate QL by ADCP depends on the hydraulic characteristics of the watercourses.

This study aims to investigate how the adoption of an online to offline (O2O) transition strategy impacts the sales volume of Kampoeng Merdeka Clothing. The O2O strategy includes various components, such as establishing O2O platforms, delivering personalized services, ensuring secure transactions, and engaging in offline business activities. The research employs a quantitative approach, focusing on consumers who have made clothing purchases from Kampoeng Merdeka Clothing in Macassar. The sample size comprises 83 respondents, deliberately selected using the Slovin approach. The data analysis and methodology involve the application of Partial Least Squares (PLS) structural equation modeling to assess both the external and internal models. The findings of this study emphasize the significant and positive influence of the variables "Build O2O Network Platform," "Provide Personalized Experience," "Safeguard Transactions Security," and "Offline Business" on driving the sales growth of Kampoeng Merdeka Clothing. These results indicate that the O2O transition strategy has a substantial impact on the brand's sales performance, with the establishment of O2O platforms and personalized services playing crucial roles. Additionally, ensuring secure transactions and engaging in offline business activities further contribute to the overall success of Kampoeng Merdeka Clothing in the market. This research sheds light on the effectiveness of the O2O approach in boosting sales for clothing brands and underscores the importance of integrating online and offline elements to maximize business outcomes.

Background: Epithelial-mesenchymal transition (EMT) is a biological process where epithelial cells lose their adhesive properties and gain invasive, metastatic, and mesenchymal properties. Maintaining the balance between epithelial and mesenchymal stage is essential for tissue homeo-stasis. Many of the genes promoting mesenchymal transformation has been identified; however, our understanding of the genes responsible for maintaining the epithelial phenotype is limited. Our objective was to identify genes responsible for maintaining the epithelial phenotype and in-hibiting EMT. Methods: RNA seq was performed using an vitro model of EMT. CTGF expres-sion was determined by qPCR and Western blot analysis. Knockout of CTGF was done using the CTGF sgRNA CRISPR/CAS9. Tumorigenic potential was determined using NCG mice. Results: Knocked-out of CTGF in epithelial ovarian cancer cells leads to the acquisition of functional characteristics associated with the mesenchymal phenotype such as Anoikis resistance, cytoskel-eton remodeling, increased cell stiffness, and acquisition of invasion and tumorigenic capacity. Conclusions: We identified CTGF is an important regulator of the epithelial phenotype, and its loss is associated with early cellular modifications required for EMT. We describe a novel role for CTGF, regulating cytoskeleton and the extracellular matrix interactions necessary for conserva-tion of epithelial structure and function. These findings provide a new window to understand the early stages on mesenchymal transformation

Recent advancements in the study of the protein complex photosystem II have clarified the sequence of events leading to the formation of oxygen during the S3->S4->S0 tran-sition, wherein the inorganic Mn4Ca(µ-O)6(OHx)4 cluster finishes photo-catalyzing the water splitting reaction (Greife et al, Nature 2023, 617, 623-628; Bhowmick et al, Nature 2023, 617, 629-636) . During this final step a tyrosine radical (TyrZ), stable for a couple of milliseconds, oxidizes a cluster bound oxygen while the hydrogen bonding patterns of nearby waters shift a proton away. A treatment of this redox reaction within the context of accepted transition state theories predicts rate constants that are significantly higher than experimentally recovered values (10^12s^-1 versus 10^3s^-1). In an effort to understand this disparity, temperature dependent experiments have revealed large entropic con-tributions to the rates with only a moderate energy of activation. We suggest that the entropic source may be related to the observed proton rearrangements, and further possible near isoenergetic variations in the nearby extended h-bonding network de-laying the realization of an ‘ideal’ transition state. In the following we explore this re-lation in the context of Eyring’s transition state theory and Marcus’ electron transfer theory, and evaluate their compatibility with the experimental evidence.

Nanostructured transition metal nitrides (TMNs) have been considered a promising substitute for precious metal catalysts toward ORR due to their multi-electron orbitals, metallic properties, and low cost. To design TMNs catalysts with high catalytic activity toward ORR, the intrinsic features of the influencing factor on the catalytic activity toward ORR of nanostructured TMNs need to be investigated. In the paper, titanium nitride (TiN), zirconium nitride (ZrN), and hafnium nitride (HfN) nanoparticles (NPs) are high-efficiency and one-step synthesized by the direct current arc plasma. TiN, ZrN, and HfN NPs with an oxidation layer are applied as the catalysts of hybrid sodium-air batteries (HSABs). The effect of composition and structure attributes of TMNs on ORR catalysis is defined as follows. (ⅰ) Composition effect. With the increase of the oxygen content, the catalytic ORR capability of TMNs decreases progressively due to the reduction of oxygen adsorption capacity; (ⅱ) Structure effect. The redistribution of the density of states (DOS) of ZrN indicates higher ORR activity than TiN and HfN. HSABs with ZrN exhibit an excellent cyclic stability up to 137 cycles (about 140 h), an outstanding rate performance, and a specific capacity of 2817 mAh·g−1 at 1.0 mA·cm−2.

Bimetallic (or multimetallic) catalysis has emerged as a powerful tool in modern chemical synthesis, offering improved reaction control and versatility. This review focuses on the recent de-velopments in bimetallic sequential catalysis for the synthesis of nitrogen heterocycles, essential building blocks in pharmaceuticals and fine chemicals. The cooperative action of two (and sometimes more) different metal catalysts enables intricate control over reaction pathways, enhancing selectivity and efficiency of N-heterocyclic compounds synthesis. By activating less reactive substrates, this multimetal catalytic strategy opens new synthetic possibilities for challenging compounds. The use of catalytic materials in bimetallic systems reduces waste and improves atom efficiency, aligning with green chemistry principles. With a diverse range of metal combinations and reaction conditions, bimetallic catalysis provides access to a broad array of N-heterocyclic compounds with various functionalities. This paper highlights the significant progress made in the past decade in this topic, emphasizing the promising potential of bimetallic catalysis in drug discovery and the fine chemical industries.

To achieve sustainable development during urbanization, construction waste is recycled for use as an aggregate in recycled concrete (RC). To determine the influence of the brick content in coarse recycled aggregates on the damage sustained by the resultant RC, the RC was first divided into seven phases: natural crushed stone, old gravel inside waste concrete, bricks, new mortar, old mortar on waste concrete surfaces, and new and old interface transition zones. The Monte Carlo method was then applied to establish a two-dimensional random aggregate model of the RC made with coarse brick aggregates. The ABAQUS software package was used to simulate a uniaxial compression test, the results of which were combined with those of a macro-test to determine the internal damage change rule of brick-containing RC. The stress–strain curves obtained from the simulation coincided well with that of the macroscopic tests. As the brick content increased, the damage zone inside the specimen and the number of microcracks increased. The stress concentration area decreased, as indicated by a lower compressive strength in the macro-test. The results indicate that higher brick contents in RC yield more initial damage inside the concrete and a lower compressive strength.

This paper offers a set of comprehensive guidelines aimed at facilitating the widespread adoption of hydrogen in the industrial hard-to-abate sectors. The authors begin by conducting a detailed analysis of these sectors, providing an overview of their unique characteristics and challenges. The paper delves into specific elements related to hydrogen technologies, shedding light on their potential applications and discussing feasible implementation strategies. By exploring the strengths and limitations of each technology, the paper offers valuable insights into its suitability for specific applications. Finally, through a particular analysis focused on the steel sector, the authors provide in-depth information on the potential benefits and challenges associated with hydrogen adoption in this particular context. By emphasizing the steel sector as a focal point, the authors contribute to a more nuanced understanding of hydrogen's role in decarbonizing industrial processes and inspire further exploration of its applications in other challenging sectors.

Prostate cancer is the most occurred malignant disease in the male population in over one-half of the countries and still constitutes the fifth leading cause of death in 2020, worldwide. Metastatic prostate cancer is a lethal malignancy that mostly is terminated within several years through the patient's death. Researchers should focus on the phenomenon which is rigorously appertaining to metastatic cascade and operating as an initiator of metastases to provide the knowledge needed to solve the problem of diagnostics and treatment of advanced prostate cancer patients. The epithelial-mesenchymal transition is one such phenomenon. The current review is based mainly on three papers published in 2021, which describe the most important tissue-specific factors managing epithelial-mesenchymal transition and are discussed with scientific papers published in acknowledged journals. The effect of the current review is the specification of profiles of precise tissue factors predicting the progression of the prostate neoplasm to its metastatic stage in a new edition.

Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease due to early metastatic spread, late diagnosis and the lack of efficient therapies. A major driver of cancer progression and hurdle to successful treatment is transforming growth factor (TGF)-β. Recent data from pancreatic cancer mouse models have shown that transcriptionally active p73 (TAp73), a p53 family member, inhibits tumor progression through promoting tumor suppressive canonical TGF-β/Smad signaling, while preventing non-canonical TGF-β signaling through extracellular signal-regulated kinases (ERK)1/2. Here, we have studied whether this mechanism also operates in human PDAC. Using the PDAC-derived tumor cell lines PANC-1 and HPAFII, we show that TAp73 induces the expression of the epithelial marker and invasion suppressor E-cadherin and the common-mediator Smad, SMAD4, while at the same time suppressing expression of the EMT master regulator SNAIL and basal and TGF-β1-induced activation of ERK1 and ERK2. Using dominant-negative and RNA interference-based inhibition of SMAD4 function we went on to show that inhibition of ERK activation by TAp73 is mediated through SMAD4. Intriguingly, both SMAD4 and the α isoform of TAp73 - but not the isoform - interfered with cell migration as shown by xCELLigence technology. Our findings highlight the role of TAp73-SMAD4 signaling in tumor suppression of human PDAC and identify direct inhibition of basal and TGF-β-stimulated pro-invasive ERK activation as an underlying mechanism.

The present study describes the development and application of a computer model of the national electricity system for the Caribbean dual-island nation of Antigua and Barbuda to investigate the cost-optimal mix of solar photovoltaics (PV), wind, and in the most novel contribution, concentrating solar power (CSP). These technologies, together with battery and hydrogen energy storage, can enable the aim of achieving 100% renewable electricity and zero carbon emissions. The motivation for this study was that while most nations in the Caribbean rely largely on diesel fuel or heavy fuel oil for grid electricity generation, many countries have renewable resources beyond wind and solar energy. Antigua and Barbuda generates 93% of its electricity from diesel-fueled generators and has set targets of becoming a net-zero nation by 2040 and having 86% renewable energy generation in the electricity sector by 2030, but the nation has no hydroelectric or geothermal resources. The modeled, optimal mix of renewable energy technologies presented here was found for Antigua and Barbuda by assessing the levelized cost of electricity (LCOE) for systems comprising various combinations of energy technologies and storage. Other factors were also considered, such as land use and job creation. It was found that 100% renewable electricity systems are viable and significantly less costly than current power systems, and that there is no single defined pathway towards a 100% renewable energy grid, but several options are available.

As shown previously, a relation between the superconducting transition temperature and some characteristic distance in the crystal lattice holds, which enables the calculation of the superconducting transition temperature, Tc, based only on the knowledge of the electronic configuration and of some details of the crystallographic structure. This relation was found to apply for a large number of superconductors, including the high-temperature superconductors, the iron-based materials, alkali fullerides, metallic alloys, and element superconductors. When applying this scheme called Roeser-Huber formula to Moiré-type superconductivity, i.e., magic-angle twisted bi-layer graphene (tBLG) and bi-layer WSe2, we find that the calculated transition temperatures for tBLG are always higher than the available experimental data, e.g., for the magic angle 1.1∘, we find Tc≈ 4.2–6.7 K. Now, the question arises why the calculation produces larger Tc’s. Two possible scenarios may answer this question: (1) The given problem for experimentalists is the fact that for electric measurements always substrates/caps are required to arrange the electric contacts. When now discussing superconductivity in atomically thin objects, also these layers may play a role forming the Moiré patterns. The consequence of such substrate-induced super-Moiré patterns is that the resulting Moiré pattern always will show a larger cell size, and thus, a lower Tc of the final structure will result. (2) A correction factor to the Roeser-Huber formalism may be required to account for the low charge carrier density of the tBLG. Here, we test both scenarios and find that the introduction of a correction factor η enables a proper calculation of Tc, reproducing the experimental data. We find that η depends exponentially on the value of Tc.

Oxygen evolution reaction is a momentous part of electrochemical energy storage and conversion devices such as rechargeable metal-air batteries. It is particularly urgent to develop low-cost and efficient electrocatalysts for oxygen evolution reactions. As a potential substitute for noble metal electrocatalysts, transition metal selenides are still challenging in improving the activity of oxygen evolution reaction and the research of reaction intermediates. In this study, a simple one-step solvothermal method was used to prepare a polymetallic compound carbon matrix composite (Co9Se8/Ni3Se4/Fe3O4@C) with a multilayered nanosheets structure. It exhibited good OER activity in an alkaline electrolyte solution with an overpotential of 268 mV at 10 mA/cm2 in an alkaline medium. Besides, this catalyst also showed excellent performance in the 24 hours stability test. The composite presents a multi-layer sheet structure, which effectively improves the contact between the active site and the electrolyte. The selenide formed by Ni and Co has a synergistic effect, Fe3O4 and Co9Se8 form a heterojunction structure, which can effectively improve the reaction activity by initiating the electronic coupling effect through the interface modification. In addition, carbon quantum dots have rich heteroatoms and electron transferability, which improves the electrochemical properties of the composites. This work provides a new strategy for the preparation of highly efficient OER electrocatalysts utilizing the multimetal synergistic effect.

Magnetic nanoparticles (MNPs) have attracted a great interest in nanomedical research. MNPs exhibit many important properties, particularly, magnetic hyperthermia for selective killing of cancer cells is one of them. In hyperthermia treatment, MNPs act as nano-heaters when they are under the influence of an alternating magnetic field (AMF). In this work, micromagnetic simulations have been used to investigate the magnetization dynamics of a single-domain nanoparticle of magnetite in an external AMF. Special attention is paid to the circumstances dealing with a dynamic phase transition (DPT). Besides, we focus on the influence of the orientation of the magnetic easy-axis of the MNP on the dynamic magnetic properties. For amplitudes of the external AMF above certain critical value, the system is not able to follow the magnetic field and it is found in a dynamically ordered phase; whereas for larger amplitudes, the state corresponds to a dynamically disordered phase and the magnetization follows the external AMF. Our results suggest that the way how the order-disorder DPT takes place, and both the metastable lifetime as well as the specific loss power (SLP), are strongly dependent on the interplay between the orientation of the magnetic easy-axis and the amplitude of the external AMF.

Taking a socio-technical perspective, I focus on solar businesses (niche market actors) in Iran. As one of the key stakeholder groups whose business prosperity is tied to the development of solar PV, they play a crucial role in accelerating the energy transition. Given the incumbent fossil-based electricity sector in Iran and the least enabling policies, I am first interested to find (i) the main drivers and barriers of solar businesses; and (ii) the roles these solar businesses play in bringing solar PV deployment forward in Iran. I collected the data via 20 semi-structured interviews with solar businesses in Golestan, Guilan, Tehran, Khorasan Razavi, and Eastern Azerbaijan Provinces in Iran. Taking an inductive approach, I considered sustainability transition and social acceptance theories as sensitising concepts to investigate common and specific points of solar business acceptance in Iran. I find ecological awareness, belief in intergenerational justice, and willingness to innovate, as the main intrinsic drivers and socioeconomic opportunity and tackling the energy imbalance as extrinsic drivers; while the lack of a common vision with the energy governors, and the low knowledge of solar PV among the customers, escalating prices, and challenges to accessing good quality solar equipment are the most prior obstacles. Moreover, I understand educating people, driving the innovative deployment of solar PV, and facilitating the diffusion of it, as the major roles of solar businesses in Iran. I find that the sustainability transition literature overlooked the key role of solar businesses specially in fossil-based and developing economies. My findings suggest that the positive intrinsic mechanisms among the solar businesses, in combination with better-enabling policy frameworks and external factors, like lifting the sanctions and joining the global energy market, climate change mitigation commitments and standards, can help solar businesspeople to lead and accelerate solar PV development in Iran.

As shown previously, a relation between the superconducting transition temperature and some characteristic distance in the crystal lattice holds, which enables the calculation of the superconducting transition temperature, Tc, based only on the knowledge of the electronic configuration and of some details of the crystallographic structure. This relation was found to apply for a large number of superconductors, including the high-temperature superconductors, the iron-based materials, alkali fullerides, metallic alloys, and element superconductors. When applying this scheme called Roeser-Huber formula to Moiré-type superconductivity, i.e., magic-angle twisted bi-layer graphene (tBLG) and bi-layer WSe2, we find that the calculated transition temperatures for tBLG are always higher than the available experimental data, e.g., for the magic angle 1.1∘, we find Tc≈ 4.2–6.7 K. Now, the question arises why the calculation produces larger Tc’s. Two possible scenarios may answer this question: (1) The given problem for experimentalists is the fact that for electric measurements always substrates/caps are required to arrange the electric contacts. When now discussing superconductivity in atomically thin objects, also these layers may play a role forming the Moiré patterns. The consequence of such substrate-induced super-Moiré patterns is that the resulting Moiré pattern always will show a larger cell size, and thus, a lower Tc of the final structure will result. (2) A correction factor to the Roeser-Huber formalism may be required to account for the low charge carrier density of the tBLG. Here, we test both scenarios and find that the introduction of a correction factor η enables a proper calculation of Tc, reproducing the experimental data. We find that η depends exponentially on the value of Tc.

From the formalism of the thermodynamics of irreversible processes and the theory of complex systems, characterization of longevity and aging and its relationship with the emergence and evolution of cancer was carried out. It was found that: 1. The rate of entropy production can be used as an index of robustness, plasticity, the aggressiveness of cancer, and as a measure of biological age; 2. The aging process, as well as the evolution of cancer, goes through what we have called “biological phase transition”; 3. The process of metastasis, which occurs through epithelial-mesenchymal transition (EMT), appears as a phase transition far from thermodynamic equilibrium and exhibits Shilnikov chaos-like dynamic behavior. This dynamic guarantees the robustness of the process and, in turn, its unpredictability; 4. It was shown that as the ferroptosis process is strengthened, the complexity of the dynamics associated with the emergence and evolution of cancer decreases. The theoretical framework developed contributes to a better understanding of the biophysical-chemical phenomena of longevity and aging and their relationship with cancer.

As one of the representatives of emerging metallic transition metal dichalcogenides, niobium ditelluride (NbTe₂) has attracted intensive interest recently due to its distorted lattice structure and unique physical properties. Here, we report on the ultrafast carrier dynamics in NbTe₂ measured using time-resolved pump-probe transient reflection spectroscopy. A thickness-dependent carrier relaxation time is observed, exhibiting a clear increase in the fast and slow carrier decay rates for thin NbTe₂ flakes. In addition, pump power dependent measurements indicate that the carrier relaxation rates are power-independent, with the peak amplitude of the transient reflectivity increasing linearly with pump power. Isotropic relaxation dynamics in NbTe₂ is also verified by performing polarization-resolved pump-probe measurements. These results provide an insight into the light-matter interactions and charge carrier dynamics in NbTe₂ and will pave the way for its applications to photonic and optoelectronic devices.

Description of redox reactions is critically important for understanding and rational design of materials for electrochemical technologies including metal-ion batteries, catalytic surfaces, or redox-flow cells. Most of these technologies utilize redox-active transition metal compounds due to their rich chemistry and their beneficial physical and chemical properties for these types of applications. A century since its introduction, the concept of formal oxidation states (FOS) is still widely used for rationalization of the mechanisms of redox reactions, but there exists a well-documented discrepancy between FOS and the electron density-derived charge states of transition metal ions in their bulk and molecular compounds. We summarize our findings and those of others which suggest that density-driven descriptors are in certain cases better suited to characterize the mechanism of redox reactions, especially when anion redox is involved, which is the blind spot of the FOS ansatz.

The energy transition requires integration of different energy carriers, including electricity, heat, and transport sectors. Energy modeling methods and tools are essential to provide a clear insight into the energy transition. However, the methodologies often overlook the details of small-scale energy systems. The study states an innovative approach to facilitate sub-national energy systems with 100% renewable penetration and sectoral integration. An optimization model, OSeEM-SN, is developed under the Oemof framework. The model is validated using the case study of Schleswig-Holstein. The study assumes three scenarios representing 25%, 50%, and 100% of the total available biomass potentials. OSeEM-SN reaches feasible solutions without additional offshore wind investment, indicating that they can be reserved for supplying other states’ energy demand. The annual investment cost varies between 1.02 bn – 1.44 bn €/yr for the three scenarios. The electricity generation decreases by 17%, indicating that with high biomass-based combined heat and power plants, the curtailment from other renewable plants can be decreased. Ground source heat pumps dominate the heat mix; however, their installation decreases by 28% as the biomass penetrates fully into the energy mix. The validation confirms OSeEM-SN as a beneficial tool to examine different scenarios for sub-national energy systems.

A new picture of the Josephson effect is devised. The radio-frequency (RF) signal, observed in a Josephson junction, is shown to stem from bound electrons, tunneling periodically through the insulating film. This holds also for the microwave mediated tunneling. The Josephson effect is found to be conditioned by the same prerequisite worked out previously for persistent currents, thermal equilibrium and occurence of superconductivity. The observed negative resistance behaviour is shown to originate from the interplay between the normal and superconducting currents.

Organic-organic interactions play important roles in the secondary organic aerosol formation, but the interactions are complex and poorly understood. Here we use environmental molecular beam experiments combined with molecular dynamics simulations to investigate the interactions between methanol and nopinone, as atmospheric organic proxies. In the experiments, methanol monomers and clusters are sent to collide with three types of surfaces, i.e., graphite, thin nopinone coating on graphite and multilayer surfaces, at temperatures between 140 K and 230 K. Methanol monomers are efficiently scattered from the graphite surface, whereas the scattering is substantially suppressed from nopinone surfaces. The desorption from the three surfaces is similar, suggesting that all the surfaces have weak or similar influences on the methanol desorption. The molecular dynamics results show that upon collisions the methanol clusters shatter, and the shattered fragments quickly diffuse and recombine to clusters. The desorption involves a series of processes, including detaching from clusters and desorbing as monomers. The experimental results also show that all trapped methanol molecules completely desorb within a short experimental time scale at temperatures of 180 K and above. At lower temperatures, the desorption rate decreases, and a long experimental time scale is used to resolve the desorption, where three desorption components are identified. The fast component is beyond the experimental detection limit. The intermediate component exhibits multi-step desorption character and has an activation energy of E_a = 0.18 ± 0.03 eV, in good agreement with simulation results. The slow desorption component is related to diffusion processes due to the weak temperature dependence.

Knowledge about the formation energies of compounds is essential to derive phase diagrams of multi-component phases with respect to elemental reservoirs. The determination of formation energies using common (semi-)local exchange-correlation approximations of density functional theory (DFT) exhibits well-known systematic errors if applied to oxide compounds containing transition metal elements. In this work, we generalize, reevaluate and discuss a set of approaches proposed and widely applied in the literature to correct for errors arising from the over-binding of the O2 molecule and from correlation effects of electrons in localized transition-metal orbitals. The DFT+U method is exemplarily applied to iron oxide compounds, and a procedure is presented to obtain U values, which lead to formation energies and electronic band gaps comparable to experimental values. Using such corrected formation energies, we derive the phase diagrams for LaFeO3, Li5FeO4 and NaFeO2, which are promising materials for energy conversion and storage devices. A scheme is presented to transform the variables of the phase diagrams from the chemical potentials of elemental phases to those of precursor compounds of a solid-state reaction, which represents the experimental synthesis process more appropriately. The discussed workflow of methods can directly be applied to other transition metal oxides.

We investigate a notable class of states peculiar to a bosonic binary mixture featuring repulsive intraspecies and attractive interspecies couplings. We evidence that, for small values of the hopping amplitudes, one can access particular regimes marked by the fact that the interwell boson transfer occurs in a jerky fashion. This property is shown to be responsible for the emergence of a staircase-like structure in the phase diagram and to strongly resemble the mechanism of the superfluid-Mott insulator transition. Under certain conditions, in fact, we show that it is possible to interpret the interspecies attraction as an effective chemical potential and the supermixed soliton as an effective particle reservoir. Our investigation is developed both within a fully quantum approach based on the analysis of several quantum indicators and by means of a simple analytical approximation scheme capable of capturing the essential features of this ultraquantum effect.

In this paper, we synthesized MC(BeA-co-MMA) copolymer microcapsules through suspension polymerization. The pendent n-behenyl group of BeA is highly crystalline, and it acts as the side-chain in the structure of BeA-co-MMA copolymer. The highly crystalline n-behenyl side-chain provides BeA-co-MMA copolymer thermal-energy-storage capacity. In order to investigate the correlation between thermal properties and crystal structure of BeA-co-MMA copolymer, the effects of monomer ratio, temperature changing and changing rate, as well as synthesis method were discussed. The monomer ratio influenced crystal transition behavior and thermal properties greatly. The DSC results proved that when the monomer ratio of BeA and MMA was 3:1, MC(BeA-co-MMA)3 showed the highest average phase change enthalpy ΔH (105.1 J·g–1). It indicated that the n-behenyl side-chain formed relatively perfect crystal region, which ensured a high energy storage capacity of copolymer. All the DSC and SAXS results proved that the amount of BeA had a strong effect on the thermal-energy-storage capacity of copolymer and the long spacing of crystals, but barely on the crystal lamella. It was found that MMA units worked like defects in the n-behenyl side-chain crystal structure of BeA-co-MMA copolymer. Therefore, a lower fraction of MMA, that is, a higher fraction of BeA contributed to a higher crystallinity of BeA-co-MMA copolymer for providing a better energy storage capacity and thermoregulation property. ST(BeA-co-MMA) copolymer sheets with the same ingredients as microcapsules were also prepared through light-induced polymerization aiming at clarifying the effect of synthesis method. The results proved that synthesis method mainly influenced the copolymer chemical component, but lightly on the crystal packing of n-behenyl side-chain.

The results reveal CILSS as the most accurate data set with a Kappa coefficient of 68% and an overall accuracy of 83%. CILSS data shows a decrease of savanna and forest whereas an increase of cropland over the period 1975 to 2013. The increase of cropland area of 30.97% from 1975 to 2013 can be related to the increase in population and their food demand, while the losses of forest area and the decrease of savanna are further amplified by using wood as energy sources and the lack of forest management. The three datasets were used to simulate future LULC changes using the Terrset Land Change Modeler. The validation of the model using CILSS data for 2013 showed a quality of 50.94%, it is only 40.04% for ESA and 20.13% for Globeland30. CILSS data was utilized to simulate the LULC distribution for the years 2020 and 2027 because of its satisfactory performances. The results show that a high spatial resolution is not a guarantee of high quality. The results of this study can be used for impact studies and to develop management strategies for mitigating negative effects of land use and land cover change.

We review the latest developments in the field of the metal-insulator transition in strongly-correlated two-dimensional electron systems. Particular attention is given to recent discoveries of a sliding quantum electron solid and interaction-induced spectrum flattening at the Fermi level in high-quality silicon-based structures.

We report on comparison between temperature-dependent magneto¬absorption and magnetotransport spectroscopy of HgTe/CdHgTe quantum wells in terms of detection of phase transition between topological insulator and band insulator states. Our results demonstrate that temperature-dependent magnetospectroscopy is a powerful tool to discriminate trivial and topological insulator phases, yet magnetotransport method is shown to have advantages for clear manifestation of the phase transition with accurate quantitative values of transition parameter (i.e. critical magnetic field Bc).

Dynamic mechanical analysis (DMA) is a versatile technique that complements the information given by the more traditional thermal analysis techniques such as differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and thermal mechanical analysis (TMA). Dynamic constants such as storage modulus, loss modulus, and loss factor are temperature dependent and provide information about interfacial bonding between reinforced fibre and polymer matrix of composite material. To study the above mentioned properties at the glass transition region, for unidirectional fibrous composites reinforced with continuous fibers a reliable model was applied. In particular, the composite material was considered as composed of three phases with the intermediate phase between matrix and fibres, the interphase, to have variable properties depending on those of main phases and the mode of preparation of the overall material. The glass transition temperature is defined as the point at which the specific volume versus temperature curve changes abruptly slope marking the region between rubbery polymer and glassy polymer nature. Hence, the behaviour of unidirectional fibrous composites was investigated at this region. Examination of the glass transition temperature, which constitutes an upper limit for the structurally important glassy region through the loss factor, was performed by its consideration as a combination of glass transition temperature of matrix and interphase.

The research field of two dimensional (2D) materials strongly relies on optical microscopy characterization tools to identify atomically thin materials and to determine their number of layers. Moreover, optical microscopy-based techniques also opened the door to study the optical properties of these nanomaterials. We present a comprehensive study of the differential reflectance spectra of 2D semiconducting transition metal dichalcogenides (TMDCs), MoS₂, MoSe₂, WS₂ and WSe₂, with thickness ranging from one layer up to six layers. We analyze the thickness-dependent energy of the different excitonic features, indicating the change in the band structure of the different TMDC materials with the number of layers. Our work provides a route to employ differential reflectance spectroscopy for determining the number of layers of MoS₂, MoSe₂, WS₂ and WSe₂.

This brief review highlights some current issues in Galactic stellar nucleosynthesis, and some recent laboratory studies by the Wisconsin atomic physics group that have direct application to stellar spectroscopy, in order to advance our understanding of the chemical evolution of our Galaxy. The relevant publication history of the lab studies are summarized, and investigations into the abundances of neutron-capture and iron-peak elements in low metallicity stars are described. Finally, new initatives in near-infrared spectroscopy are briefly explored.

This paper investigates the theoretical foundation for developing renewable geothermal resources locally. For this reason, we pay attention to the role of communities in geothermal development. This study presents arguments for a framework that approaches the geothermal resources as an endogenous factor of community development. To analyse it, we create a model that explains the local economic characters of the geothermal exploitation beyond its geological conditions. It aims to conceptualise a community based geothermal development standard referring to the endogeneity principle. Geothermal energy is given attention since the characteristics of this resource determine its use locally. We argue that the role of communities in geothermal exploitation is pivotal in the process of green growth for further expansion of geothermal energy use.

Positive Health (PH) has been described as a promising transformative innovation to address the challenges of promoting well-being and reducing the burden of disease. The aim of this study is to review the current state of knowledge about PH as introduced by Huber et al. (2016) within the available scientific literature. A rapid review of the literature following the Cochrane Rapid Review recommendations. Three databases were searched (PubMed, Google Scholar, and CINAHL). Data were extracted and synthesized using a narrative approach. A total of 55 articles were included. Initial evaluation studies reveal promising results both at individual and collective levels. However, a need is expressed in several articles for further refinement of the conceptualization of PH and ways to make the effects of the PH approach more measurable. Professionals also expressed a desire for a more informed application and elaboration of the PH method across various settings and populations to enhance its effectiveness in practice. This rapid review highlights the transformative potential of PH in shifting from a disease-focused to a health-oriented paradigm of healthcare. It underscores the need for continued research regarding further development of the concept and its practical method, along with the necessity for methodological innovation.

Melting, solidification and viscosity properties of a multicomponent Fe-Cu-Nb-Mo-Si-B alloys with low aluminum addition up to 0.42 at.% Al were studied using an oscillating cup viscometer. It is shown that melting and solidification are divided into two stages with a knee point at 1461 K. The temperature dependences of the liquid fraction between the liquidus and solidus temperatures during melting and solidification are calculated. It has been proven that aluminum accelerates the processes of melting and solidification and leads to an increase in liquidus and solidus temperatures. In the liquid state at temperatures above 1700 K in an alloy with a low aluminum content, the activation energy of viscous flow increases. This growth was associated with the liquid – liquid structure transition caused by the formation of large clusters based on the metastable Fe23B6 phase. Aluminum atoms attract iron and boron atoms and contribute to the formation of clusters based on the Fe2AlB2 phase and metastable phases of a higher order.

Nanocomposites of cyanate ester resin (CER) filled with three different reactive amino-functionalized polyhedral oligomeric silsesquioxane (POSS) were synthesized and characterized. The addition of a small quantity (0.1 wt.%) of amino-POSS chemically grafted to the CER network led to increasing thermal stability of CER matrix. A significant increase of the glass transition temperature, Tg (DSC data), and the temperature of α relaxation, Tα (DMTA data), by 45-55 оС of CER matrix with loading of nanofillers was evidenced. CER/POSS films exhibited a higher storage modulus than that of neat CER in the temperature range investigated. It was evidenced that CER/aminopropylisobutyl (APIB)-POSS, CER/N-phenylaminopropyl (NPAP)-POSS, and CER/aminoethyl aminopropylisobutyl (AEAPIB)-POSS nanocomposites induced a more homogenous α relaxation phenomenon with higher Tα values and an enhanced nanocomposite elastic behavior. Furthermore, CER/amino-POSS nanocomposites possessed higher specific surface area, gas permeability (CO2, He), and diffusion coefficients (CO2) values than those for neat CER, due to increasing free volume of the nanocomposites studied that is very important for their gas transport properties. Permeability grew respectively by about 2 (He) and 3.5-4 times (СО2), and diffusion coefficient of CO2 increased approximately twice for CER/amino-POSS nanocomposites in comparison with the neat CER network. The efficiency of amino-functionalized POSS in improving the thermal and transport properties of the CER/amino-POSS nanocomposites increased in a raw of reactive POSS containing one primary (APIB-POSS) &lt; eight secondary (NPAP-POSS) &lt; one secondary and one primary (AEAPIB-POSS) amino groups. APIB-POSS had the least strongly pronounced effect, since it could form covalent bonds with the CER network only by reaction of one –NH2 group, while AEAPIB-POSS displayed the most highly marked effect, since it could easily be incorporated into the CER network via reaction of –NH2 and –NH– groups with –O–C≡N groups from CER.

Cystic Fibrosis is a chronic disease affecting multiple systems including the GI tract. Clinical manifestation in patients can start as early as infancy and vary across different age groups. With the advent of new highly effective modulators, the life expectancy of PwCF has improved significantly. Various GI aspects of CF care such as nutrition are linked to the overall improvement in morbidity, lung function, and quality of life of PwCF. The variable clinical presentations and management of GI diseases in pediatrics and adults CF should be recognized. Therefore, it is necessary to ensure efficient transfer of information between pediatric and adult providers for proper continuity of management and coordination of care at the time of transition. The transition of care is a challenging process for both patients and providers and currently, there are no specific tools for GI providers to help ensure smooth transition. In this review, we aim to highlight the crucial features of GI care at the time of transition and provide a checklist that can assist in ensuring an effective transition and ease the challenges associated with it.

We present a mixing length based algebraic turbulence model calibrated to pipe flow; the main purpose of the model is to capture the increasing turbulence production-to-dissipation ratio observed in connection with the high Reynolds number transition region. The model includes the mixing length description by Gersten and Herwig which takes the observed variation of the von Kármán number with Reynolds number into account. Pipe wall roughness effects are included in the model. Results are presented for area-averaged (integral) quantities which can be used both as a self-contained model and as initial inlet boundary conditions for computational fluid dynamics simulations.