This article is devoted to discussing the famous Impact factor citation suited to indicate the published scientific result's significance. Considering this problem based on the available statistical data, we demonstrate that: Impact factor follows a distribution having a heavy power tail that may lead to inconsistency in scientifically comparable journals' evaluation. Further, we remark that many papers recognized as sleeping and seemingly sleeping beauties are not considered when calculating. This makes the impact factor unsuitable in evaluating the original, groundbreaking discoveries and their consequences. Due to permanent changes in the composition of the underlying datasets, the impact factor can not be considered as a reliable indicator and to be used as a consistent evaluation metric. Overall, discussing all represented impact factor obstacles and other appropriate considerations, we conclude that the considered index can hardly be used as a reliable estimator of the publication's significance.

Accidents at mining enterprises, including tailing dumps, pose significant threats to human lives, structures, and the environment. This study focuses on designing, constructing, and operating tailing dumps in Siberia's northern region. To ensure safety and minimize environmental impacts, comprehensive scientific monitoring and research were conducted at all stages, including design, construction, operation, and disposal. The aim was to create a uniform mass within the dam body, requiring understanding of the tailings' structure and technological characteristics during placement. Parameters like particle size, distribution, density, and moisture content were considered to assess tailings' physical and geometric properties. Estimated monitoring was introduced as a permanent model to quickly assess the stability of hydrotechnical constructions. This involved monitoring changes in exploitation properties, structure height, beach length, and water levels. A controlled inwashing technology for subsequent dam layers was developed. Complex research facilitated the formulation of an estimated monitoring methodology and an algorithm for tailing dam formation. Practical application demonstrated high reliability and confirmed load-bearing capacity, allowing for the forecast of dam stability and safe execution. Findings led to alterations in work techniques, ensuring safe and efficient operation of tailing dams.

Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat®, have failed in Phase III clinical trials. As an alternative strategy, recent efforts have been focussed on the development of more selective inhibitors or targeting other domains than their active sites (e.g., exosites, ectosites) through specific small molecule inhibitors or monoclonal antibodies. Here, we present some examples that aim to better understand the mechanisms of conformational changes/allosteric control of MMPs functions. In addition to MMP inhibitors, we discuss unbiased global approaches such as proteomics and N-terminomics to identify new MMP substrates and achieve a better understanding of the roles of these proteases in diseases.

Financial time series and other human-driven, non-natural processes are known to exhibit fat-tailed outcome distributions. That is, such processes demonstrate a greater tendency for extreme outcomes than the normal distribution or other natural distributional processes would predict. We examine the mathematical expectation, or simply "expectation," traditionally the probability-weighted outcome, regarded since the seventeenth century as the mathematical definition of "expectation." However, when considering the "expectation" of an individual confronted with a finite sequence of outcomes, particularly existential outcomes (e.g., a trader with a limited time to perform or lose his position in a trading operation), we find this individual "expects" the median terminal outcome over those finite trials, with the classical seventeenth-century definition being the asymptotic limit as trials increase to this. Since such finite-sequence "expectations" often differ in values from the classic one, so do the optimal allocations (e.g., growth-optimal). We examine these for fat-tailed distributions. The focus is on implementation, and the techniques described can be applied to all distributional forms.

In article questions of development low-waste technologies of processing of steel-smelting slag are considered, gland allowing by extraction and its connections from steel-smelting slag to receive additional raw materials for production became, and the remains to use in building industry. Studying of gravitational methods of enrichment of steel-smelting slag and heat treatment the ore-fuel of pellets is the basis for work. Proceeding from it, in work modern physic-mechanical, chemical and physical and chemical methods of researches (UV-spectroscopy, electronic microscopy, the granulometric analysis) are used.