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Preprint ARTICLE | doi:10.20944/preprints202307.1417.v1

Phenotypic Differences among Recently Diagnosed Drug-Naïve Patients with Parkinson’s Disease with or without SNCA Polymorphisms

Santiago Pérez-Lloret, Alejandro Enet, Guenson Chevalier, Sofia Bordet, Hanny Barbar, Francisco Capani, Lucas Udovin, Matilde Otero-Losada, Francisco Barrantes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: single nucleotide polymorphism; Parkinson’s disease; alpha-synuclein; phenotype, pathophysiology; PD-related variants

Online: 20 July 2023 (12:46:20 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202104.0606.v2

Role of a-Synuclein in Cell Biology: A Hypothesis and its Implications in Neurodegenerative Diseases

Renu Minda

Subject: Biology And Life Sciences, Biophysics Keywords: Parkinson’s disease; alpha-synuclein; Lewy bodies; phase transition; thermodynamics; and mitochondria

Online: 10 January 2022 (12:23:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0052.v1

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes

Georg Auburger, Suzana Gispert, Sylvia Torres-Odio, Marina Jendrach, Nadine Brehm, Júlia Canet-Pons, Jana Key, Nesli-Ece Sen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson's disease; brain phosphorylome; PINK1, alpha-synuclein; microtubular cytoskeleton; autophagy; synaptic signaling

Online: 7 June 2019 (03:21:19 CEST)

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Hereditary Parkinson’s disease (PD) can be triggered by an autosomal dominant overdose of alpha-Synuclein (SNCA) as stressor or the autosomal recessive deficiency of PINK1 Serine/Threonine-phosphorylation activity as stress-response. We demonstrated the combination of PINK1-knockout with overexpression of SNCAA53T in double mutant (DM) mice to exacerbate locomotor deficits and to reduce lifespan. To survey posttranslational modifications of proteins underlying the pathology, brain hemispheres of old DM mice underwent quantitative label-free global proteomic mass spectrometry, focused on Ser/Thr-phosphorylations. As exceptionally strong effect, we detected >300-fold reductions of phosphoThr1928 in MAP1B, a microtubule-associated protein, and a similar reduction of phosphoSer3781 in ANK2, an interactor of microtubules. MAP1B depletion is known to trigger perturbations of microtubular mitochondria trafficking, neurite extension and synaptic function, so it was noteworthy that relevantly decreased phosphorylation was detected also for other microtubule and microfilament factors, namely MAP2S1801, MARK1S394, MAP1AT1794, KIF1AS1537, 4.1NS541, 4.1GS86 and ADD2S528. While the MAP1B heavy chain supports regeneration and growth cones, its light-chain assists DAPK1-mediated autophagy. Interestingly, relevant phosphorylation decreases of DAPK2S299, VPS13DS2429 and VPS13CS2480 in the DM brain affected regulators of autophagy, which are implicated in PD. Overall, significant downregulations were enriched for PFAM C2 domains, other kinases, and synaptic transmission factors upon automated bioinformatics, while upregulations were not enriched for selective motifs or pathways. Validation experiments confirmed the change of LC3 processing as reflection of excessive autophagy in DM brain, and dependence of ANK2/MAP1B expression on PINK1 levels. Our new data provide independent confirmation in a mouse model with combined PARK1/PARK4/PARK6 pathology that MAP1B/ANK2 phosphorylation events are implicated in Parkinsonian neurodegeneration. These findings expand on previous observations in D. melanogaster that the MAP1B ortholog futsch in the presynapse is a primary target of the PARK8 protein LRRK2, and on a report that MAP1B is a component of the pathological Lewy body aggregates in PD patient brains. Similarly, ANK2 gene locus variants are associated with the risk of PD, ANK2 interacts with PINK1/Parkin-target proteins such as MIRO1 or ATP1A2, and ANK2-derived peptides are potent inhibitors of autophagy.

Preprint REVIEW | doi:10.20944/preprints201702.0020.v1

Potential Modes of Intercellular Alpha-Synuclein Transmission

Dario Valdinocci, Rowan A. W. Radford, Sue Maye Siow, Roger S. Chung, Dean L. Pountney

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: alpha-synuclein; Parkinsons disease; dementia with Lewy bodies; multiple system atrophy; tunelling nanotube; glymphatic system; cell-to-cell spread

Online: 7 February 2017 (03:24:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0334.v1

The Role of Alpha-Synuclein And Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders

C. Alejandra Morato Torres, Zinah Wassouf, Faria Zafar, Danuta Sastre, Tiago Fleming Outeiro, Birgitt Schüle

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alpha-synuclein; SNCA; PARK2; 22q11.2 deletion syndrome; autism spectrum disorders; neuronal development; Parkinson’s disease; neurodegeneration; synaptic dysfunction

Online: 15 July 2020 (11:36:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0202.v1

Accumulation of Alpha-Synuclein and Increase in the Inflammatory Response in the Substantia Nigra, Jejunum, and Colon, in a Model of O3 Pollution in Rats

Marlen Valdés-Fuentes, Erika Rodríguez-Martínez, Selva Rivas-Arancibia

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ozone pollution; neurodegeneration; Alpha-synuclein; inflammation; NFκB; Th17; substantia nigra; gut

Online: 2 April 2024 (12:16:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1829.v1

Is this the Simplest Possible Biosensor? A Surface Imprinted Polymer EIS Sensor for Detecting Alpha-synuclein, a Parkinson’s Disease Biomarker

Roslyn Massey, Rishabh Appadurai, Ravi Prakash

Subject: Chemistry And Materials Science, Biomaterials Keywords: surface imprinted polymers; electroimpedance spectroscopy; label-free biosensors; parkinson’ s disease; α -synuclein

Online: 25 January 2024 (15:47:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0197.v1

Alpha-Synuclein at the Interface between Depression, Parkinson’s Disease and Dementia: Evidence from Epidemiology, Population Genetics and Gene-Environment Interactions

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: alpha-synuclein; SNCA; major depression; dysthymia; Parkinson’s disease; dementia; neurodegeneration; gene-environment interaction; PM2.5; pesticides

Online: 14 September 2022 (08:38:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0142.v1

Simultaneous Occurrence of Bioactive Compounds (Melatonin, Protocatechuic Acid and Hydroxytyrosol) Increases Their Neuroprotective Effects Against Alpha-Synuclein-Induced Proteotoxicity

Marta Gallardo-Fernández, Ruth Hornedo-Ortega, Ana B Cerezo, Ana M Troncoso, Mª Carmen Garcia-Parrilla

Subject: Biology And Life Sciences, Toxicology Keywords: melatonin, protocatechuic acid, hydroxytyrosol, α-synuclein, toxicity, amyloid aggregation, neurodegeneration, Parkinson´s disease, olive oil, wine

Online: 6 November 2018 (13:09:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0174.v1

Pathological Relevance of Post-translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy

Berkiye Sonustun, Firat M Altay, Catherine Strand, Geshanthi Hondhamuni, Thomas T Warner, Hilal A Lashuel, Rina Bandopadhyay

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alpha-synuclein; post-translational modifications; Parkinson’s disease; Multiple system atrophy; Lewy bodies; Lewy neurites; Glial cytoplasmic inclusions; phosphorylation; nitration; immunohistochemistry

Online: 12 January 2022 (14:31:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0018.v1

The Aggregation Conditions Define Whether EGCG Is an Inhibitor or Enhancer of α-Synuclein Amyloid Fibril Formation

Rebecca Sternke-Hoffmann, Alessia Peduzzo, Najoua Bolakhrif, Rainer Haas, Alexander K. Buell

Subject: Biology And Life Sciences, Biophysics Keywords: amyloid; α-synuclein; EGCG; inhibition

Online: 3 February 2020 (05:45:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202208.0061.v1

Epigenetics and Dysfunctional Energy Factors of Neurodegenerative Disease with Therapeutic Potential of H₂O₂ as Neuroprotective Agent

Sri Widyarti, Syahputra Wibowo, Akhmad Sabarudin, Intan Abhirama, Sutiman Bambang Sumitro

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: alpha-synuclein; energy; H2O2; mitochondria; neurodegenerative disease

Online: 2 August 2022 (10:13:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0435.v1

Disease-Specific α-Synuclein Seeding and Structural Properties in Lewy Body Disease and Multiple System Atrophy are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain

Ain Kim, Ivan Martinez-Valbuena, Jun Li, Anthony E. Lang, Gabor Geza Kovacs

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: alpha-synuclein; protein extraction; FFPE; SAA; seeding behavior

Online: 27 March 2023 (03:23:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0002.v1

The Catecholaldehyde Hypothesis for the Pathogenesis of Catecholaminergic Neurodegeneration: What We Know and What We Don’t Know

David S Goldstein

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Catecholaldehyde; DOPAL; Autotoxicity; Monoamine Oxidase; Dopamine; Alpha-Synuclein

Online: 3 May 2021 (09:08:57 CEST)

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3,4-dihydroxyphenylacetaldehyde (DOPAL) is the focus of the catecholaldehyde hypothesis for the pathogenesis of Parkinson disease and other Lewy body diseases. The catecholaldehyde is produced via oxidative deamination catalyzed by monoamine oxidase (MAO) acting on cytoplasmic dopamine. DOPAL is autotoxic, in that it can harm the same cells in which it is produced. Normally DOPAL is detoxified by aldehyde dehydrogenase (ALDH)-mediated conversion to 3,4-dihydroxyphenylacetic acid (DOPAC), which rapidly exits the neurons. Genetic, environmental, or drug-induced manipulations of ALDH that build up DOPAL promote catecholaminergic neurodegeneration. A concept derived from the catecholaldehyde hypothesis imputes deleterious interactions between DOPAL and the protein alpha-synuclein (S), a major component of Lewy bodies. DOPAL potently oligomerizes S, and S oligomers impede vesicular and mitochondrial functions, shifting the fate of cytoplasmic dopamine toward MAO-catalyzed formation of DOPAL—destabilizing vicious cycles. Direct and indirect effects of DOPAL and of DOPAL-induced misfolded proteins could “freeze” intra-neuronal reactions, plasticity of which is required for neuronal homeostasis. The extent to which DOPAL toxicity is mediated by interactions with S, and vice versa, are poorly understood. Because of numerous secondary effects such as augmented spontaneous oxidation of dopamine by MAO inhibition, there has been insufficient testing of the catecholaldehyde hypothesis in animal models. The clinical pathophysiological significance of genetics, emotional stress, environmental agents, and interactions with numerous proteins relevant to the catecholaldehyde hypothesis are matters for future research. The imposing complexity of intra-neuronal catecholamine metabolism seems to require a computational modeling approach to elucidate clinical pathogenetic mechanisms and devise pathophysiology-based, individualized treatments.

Preprint CONCEPT PAPER | doi:10.20944/preprints202304.0108.v1

Towards a Biological Definition of Parkinson’s Disease

Günter U. Höglinger, Charles H. Adler, Daniela Berg, Christine Klein, Tiago F. Outeiro, Werner Poewe, Ronald Postuma, Jon Stoessl, Anthony E. Lang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; genetics; α-synuclein; neurodegeneration; clinical manifestation; diagnosis

Online: 7 April 2023 (03:54:11 CEST)

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With the growing hope that disease-modifying treatments could target the molecular basis of neurodegenerative diseases even before the onset of symptoms, there is mounting pressure to define disease entities based on pathophysiology rather than on clinical syndromes. The Alzheimer’s disease research community has recently transitioned from diagnostic criteria based on an amnestic syndrome to a purely biomarker-based disease definition, relying on the demonstration of amyloid-beta pathology, tau pathology, and neurodegeneration. In contrast, current diagnostic criteria for Parkinson’s disease still rely on the presence of the well-described clinical syndrome of parkinsonism, with the addition of characteristic motor- and non-motor signs and symptoms. However, there is now unequivocal evidence that Parkinson’s disease starts years before the onset of parkinsonism. Furthermore, neuropathologically defined Lewy body disease is clinically heterogeneous, combining a range of motor, non-motor, dopaminergic and non-dopaminergic features. Finally, clinically defined Parkinson’s disease has diverse underlying etiologies most, but not all, associated with α-synuclein positive Lewy pathology. In light of recent scientific advances, we propose a biologically based definition for the diagnosis of Parkinson's disease, initially to be used for research purposes. The criteria use a three-component ‘G-S-N’ system. The first is documentation of defined gene variants (‘G’), which cause or strongly predispose to PD as the most upstream component. The second is α-synuclein pathology (‘S’), currently defined as pathological α-synuclein deposition in tissue or positive α-synuclein seeding assays. The third is evidence of underlying neurodegeneration (‘N’), currently defined by specific neuroimaging procedures. The associated clinical syndrome (‘C’) is defined by a single high-specificity feature or multiple lower-specificity features. Initiating this transition will enable the field to fuel both basic and clinical research and move closer to the precision medicine required to develop clinically meaningful disease-modifying therapies. We acknowledge current limitations, ethical implications, and the need for prospective validation of this approach.

Preprint REVIEW | doi:10.20944/preprints202011.0380.v1

Bacteria, Lipopolysaccharides, Amyloid and the Role of Iron Dysregulation in Parkinson’s Disease

Marthinus Janse van Vuuren, Theodore Albertus Nell, Jonathan Ambrose Carr, Douglas B Kell, Etheresia Pretorius

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Bacteria; Lipopolysaccharides; Gingipains; Amyloid and Parkinson’s disease; α-Synuclein

Online: 13 November 2020 (13:22:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0173.v1

Up-And-Down γ-Synuclein Transcription in Dopamine Neurons Translates Into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice

Rubén Pavia-Collado, Raquel Rodríguez-Aller, Diana Alarcón-Arís, Lluís Miquel-Rio, Esther Ruiz-Bronchal, Verónica Paz, Leticia Campa, Mireia Galofré, Véronique Sgambato, Analia Bortolozzi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: γ-synuclein; AAV vector; antisense oligonucleotide; cognitive dysfunction; dopamine; motor deficits

Online: 12 January 2022 (14:27:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0108.v1

Systematic Surveys of Iron Homeostasis Mechanisms reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence

Jana Key, Nesli Ece Sen, Aleksandar Arsovic, Stella Krämer, Robert Hülse, Natasha Nadeem Khan, David Meierhofer, Suzana Gispert, Gabriele Koepf, Georg Auburger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Synuclein; CPT1A; MMP14; PYGL; Tfrc; Ireb2; Pgrmc1; Hmox1; Cyp46a1; Slc11a2; Slc25a37

Online: 5 September 2020 (03:54:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0587.v1

Pulsed Telecommunication Signals of Non-ionizing Radiation Affect Amyloid Precursor Protein and α-Synuclein Metabolism in Non-neural Human Cells

AIKATERINA STEFI, KATERINA SKOUROLIAKOU, LUKAS MARGARITIS, DIDO VASSILACOPOULOU

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RF/Microwaves; mobile phone; HEK293; APP; α-synuclein; oxidative stress; non-ionizing EMR

Online: 26 August 2020 (14:46:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0463.v1

α-Synuclein Amyloid Fibrils Investigation with the Use of Fluorescent Probe Thioflavin T

Anna I. Sulatskaya, Natalia P. Rodina, Maksim I. Sulatsky, Olga I. Povarova, Iuliia A. Antifeeva, Irina M. Kuznetsova, Konstantin K. Turoverov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: α-synuclein; amyloid fibrils; fibrillogenesis; thioflavin T; equilibrium microdialysis; binding parameters; structural polymorphism

Online: 28 June 2018 (10:50:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0245.v1

Parkinson’s Disease: Cells Succumbing to Lifelong Dopamine-related Oxidative Stress and Other Bioenergetic Challenges

Hirohisa Watanabe, Johannes M. Dijkstra, Toshiharu Nagatsu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; substantia nigra; dopamine; neuromelanin; α-synuclein; oxidative stress; mitochondria; calcium; energy; ATP

Online: 3 January 2024 (10:41:13 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1349.v1

A Novel NOX Inhibitor Alleviates Parkinson’s Disease Pathology in PFF-Injected Mice

Kwadwo Ofori, Anurupa Ghosh, Dinesh Kumar Verma, Darice Wheeler, Gabriela N Cabrera, Jong-Bok Seo, Yong-Hwan Kim

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: α-Synuclein preformed fibrils (PFF); cytotoxicity; Reactive Oxygen Species (ROS); oxidative stress; and protein aggregation

Online: 18 August 2023 (10:55:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0230.v1

Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2

Lindsey A. Starr, Luke E. McKay, Kylie N. Peter, Lena M. Seyfarth, Laura A. Berkowitz, Kim A. Caldwell, Guy A. Caldwell

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alpha-synuclein; ADAR; C. elegans; dopamine; neurodegeneration; Parkinson's disease; RNA editing; xanthine dehydrogenase; ABC transporter

Online: 13 March 2023 (10:34:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0301.v1

Role of the Night-Time Systemic Processes and the Astrocyte Tryptophan-Melatonin Pathway in the Regulation of α-Synuclein and Wider Parkinson’s Disease Pathophysiology

George Anderson

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: α-synuclein; Parkinson’s disease; mitochondria; melatonin; glucocorticoid receptor; aryl hydrocarbon receptor; TrkB; gut microbiome; circadian; treatment

Online: 7 November 2023 (02:28:54 CET)

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An array of diverse processes and factors have been linked to the pathoetiology and pathophysiology of Parkinson’s disease (PD), including systemic CNS factors. This article reviews some of the many processes and factors linked to the emergence and progression of PD that culminates in the loss of substantia nigra pars compacts (SNpc) in PD patients. It is proposed that SNpc astrocytes may be a key hub, with numerous systemic and CNS factors acting to suppress the astrocyte tryptophan-melatonin pathway, leading to a loss of astrocyte melatonin and lactate for SNpc dopamine neurons. Consequently, dopamine neurons show an increase in α-synuclein, oxidative stress and suboptimal mitochondrial function, partly due to the loss of melatonin induced PTEN-associated kinase (PINK)1/parkin and mitophagy. This leads to an increase in the major histocompatibility (MHC)-1 and the chemoattraction of CD8+ T cells that destroy SNpc dopamine neurons in an ‘autoimmune’/’immune-mediated’ manner. The upstream processes driving the end-point ‘chaos’ of SNpc dopamine neuron loss are proposed to be driven by the suppression of night-time pineal melatonin, gut microbiome derived butyrate and possibly bcl2-associated athanogene (BAG)-1, which all act to suppress the glucocorticoid receptor (GR) translocation to the nucleus in all systemic and CNS cells, thereby potentiating the effects of the rising levels of cortisol over the night and accelerated rise in the course of the cortisol awakening response (CAR). The potentiation of cortisol effects at the GR has consequences for the homeostatic regulation of the diverse array of systemic and CNS microenvironments, as well as a distinct regulation of different immune and glia cells. The morning CAR is classically proposed to ‘prepare the body for the coming day’. However, the differential regulation of the GR over the circadian rhythm at night would indicate that such preparation for the coming day may be powerfully determined by night-time factors and processes. The article integrates this systemic, night-time pathoetiology with the ‘immune-mediated’ processes that ultimately drive SNpc dopamine neuron loss. This has a number of novel future research and treatment implications.

Preprint REVIEW | doi:10.20944/preprints202109.0376.v1

Revisit the Cellular Transmission and Emerging Techniques in Proteinopathies

JIngwen Jiang, Yu Liu, Qihui Wu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; Parkinson’s disease; Aβ cascade hypothesis; a-synuclein aggregation and spreading; transcriptomics of nervous system

Online: 22 September 2021 (11:33:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1592.v1

In Silico and In Vitro Study towards the Rational Design of 4,4′-Disarylbisthiazoles as a Selective α-Synucleinopathy Biomarker

Bright Uzuegbunam, Junhao Li, Wojciech Paslawski, Wolfgang Weber, Per Svenningsson, Hans Ågren, Hooshyar Yousefi B

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: α-synuclein aggregates; 4,4'-diarylbisthiazole; binding affinity; Hantzsch thiazole synthesis; lipophilicity; O-fluoroethylation; O-fluoroPEGylation; O-methylation

Online: 25 October 2023 (08:36:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.2149.v2

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Érica Novaes Soares, Ana Carla dos Santos Costa, Gabriel de Jesus Ferrolho, Rodrigo Portes Ureshino, Bruk Getachew, Silvia Lima Costa, Victor Diogenes Amaral Da Silva, Yousef Tizabi

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Parkinson’ s disease, Dopamine, Acetylcholine, Nicotine, Nicotinic receptors, Microglia, Astroglia, Oligodendrocyte, NG2 Cells, Alpha-Synuclein, Toll-Like receptors, Neuroinflammation, Neuroprotection

Online: 4 March 2024 (09:56:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0149.v1

Transcript Variants of Genes Involved in Neurodegeneration Are Differentially Regulated by the Apoe and Mapt Haplotypes

Sulev Koks, Abigail Pfaff, Vivien Bubb, John Quinn

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Apolipoprotein E (ApoE); microtubule associated protein (MAPT); synuclein alpha (SNCA); eQTL; TOMM40; KANSL1; mitochondria; Parkinson’s Progression Markers Initiative (PPMI)

Online: 8 January 2021 (11:45:19 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202210.0383.v2

Pioneering Organelle Structural Biology: Golgi Apparatus Dysfunction in Parkinson’s Disease, Neurodevelopmental Disorders, and Cancer

Daniel Gómez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: structural biology; organelles; Golgi Apparatus (GA); Parkinson’s disease (PD); cryo-ET; alpha-synuclein; neurodegenerative diseases; soft X-ray tomography (SXT); cancer; NDDs

Online: 5 December 2022 (02:27:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0001.v1

Using High-Content Screening Technology as a Tool to Generate Single-Cell Patient-Derived Gene-Corrected Isogenic iPS Clones for Parkinson’s Disease Research

Peter A. Barbuti, Paul M. Antony, Bruno F.R. Santos, François Massart, Gérald Cruciani, Claire M. Dording, Jonathan Arias, Jens C. Schwamborn, Rejko Krüger

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: CRISPR-Cas9; high-content screening (HCS); fluorescent-activated cell sorting (FACS); Parkinson's disease (PD); patient-derived iPS; single-cell clones; isogenic cell lines; SNCA; alpha-synuclein; A30P

Online: 2 May 2020 (11:20:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0476.v1

Meta-Analysis of the Mechanisms Underlying COVID-19 Modulation of Parkinson’s Disease

Jonathan Zhang, Muhammed Bishir, Sharman Barbhuiya, Sulie L Chang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: QIAGEN Knowledge Base (QKB); Ingenuity Pathway Analysis (IPA); Network Meta-analysis (NMA); Parkinson’s disease (PD); severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2); Coronavirus Disease-2019 (COVID-19); Neuroinflammation; Synuclein Alpha (SNCA); Angiotensin-converting enzyme-2 (ACE2)

Online: 7 July 2023 (10:55:52 CEST)

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