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Preprint REVIEW | doi:10.20944/preprints202308.1664.v1

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for Fast-Track Team-Based Approach

Giorgio Ventoruzzo, Giulia Mazzitelli, Umberto Ruzzi, Francesco Liistro, Alessia Scatena, Eugenio Martelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: peripheral arterial disease; critical limb ischemia; chronic limb-threatening ischemia; survival; mortality; limb salvage

Online: 25 August 2023 (02:41:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.0172.v1

Whole-Body Cryostimulation, a Complementary Treatment for Phantom Limb Syndrome: Preliminary Evidence from a Case Study

Paolo Piterà, Isabella Springhetti, Angelo Alito, Federica Verme, Jacopo Maria Fontana, Paolo Capodaglio

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: whole-body cryostimulation; phantom limb pain; phantom limb syndrome; neuropathic pain; central sensitization

Online: 3 November 2023 (04:12:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0268.v1

Extensive Limb Lengthening for Achondroplasia and Hypochondroplasia

Dror Paley

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: achondroplasia; hypochondroplasia; dwarfism; short-limb; short stature; FGFR3; skeletal dysplasia; genetic condition; extensive limb lengthening

Online: 12 May 2021 (11:22:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1071.v1

Error-enhancement for upper limb rehabilitation in the chronic phase after stroke: a 5-day pre-post intervention study

Marjan Coremans, Eli Carmeli, Ineke De Bauw, Bea Essers, Robin Lemmens, Geert Verheyden

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: stroke; upper limb rehabilitation; error-enhancement

Online: 14 December 2023 (10:44:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0915.v1

Exploring Methodological Issues in Mental Practice for Post-stroke Paralytic Lateral Upper Limb Function: A Scoping Review

Akira Nakashima, Ryohei Okamura, Takefumi Moriuchi, Kengo Fujiwara, Toshio Higashi, Kounosuke Tomori

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Mental practice; stroke; upper limb function; methodology

Online: 12 January 2024 (04:00:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1881.v1

Hospital Readmission of Patients with Diabetic Foot Ulcers: Prevalence, Causes and Outcomes

Marco Meloni, Aikaterini Andreadi, Valeria Ruotolo, Maria Romano, Ermanno Bellizzi, Laura Giurato, Alfonso Bellia, Luigi Uccioli, Davide Lauro

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetes; diabetic foot; hospital admission; limb salvage

Online: 27 June 2023 (10:18:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0160.v1

Methodology for the Design of Rehabilitation Robots: Application in an Exoskeleton for Upper Limb Rehabilitation

Giorgio Mackenzie Cruz Martinez, Luis Adrian Zuñiga Aviles

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: methodology; exoskeleton; upper limb rehabilitation; design; digital twin

Online: 14 June 2020 (03:27:20 CEST)

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Working Paper ARTICLE

An Estimation Algorithm for General Linear Single Particle Tracking Models with Time-Varying Parameters

Boris Godoy, Nicholas Vickers, Sean Andersson

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: single particle tracking; single molecule biophysics; fluorescence

Online: 25 January 2021 (12:26:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0083.v1

Electrical Manipulation, Characterization and Application of Single Cell

Weitao Zhu, Jiaao Wang, Hongzhi Luo, Sutong Liu, Binwen Luo, Xue Li, Shan Liu, Chenzhong Li

Subject: Engineering, Bioengineering Keywords: single-cell analysis; electrical manipulation; single-cell application

Online: 1 August 2023 (10:50:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0275.v1

Understanding the Impact of COVID-19 on Angioplasty Service and Outcome of Patients Treated for Critical Limb Ischaemia: A Single-Centre Retrospective Cohort Study

Alexander D. Rodway, Jenny Harris, Lydia Hanna, Charlotte Allan, Felipe Pazos-Casal, Ciara Giltinan, Ali Dehghan-Nayeri, Andre Santos, Martin B. Whyte, Nikolaos Ntagiantas, Ivan Walton, Richard Brown, Simon S. Skene, Ajay Pankhania, Benjamin C.T. Field, Gary D. Maytham, Christian Heiss

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: day-case angioplasty; critical limb ischaemia; peripheral artery disease

Online: 5 June 2023 (08:37:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0579.v1

Pneumatic Compression Combined with Standard Treatment after Total Hip Arthroplasty: Effects on Edema of the Operated Limb and on Physical Outcomes. A Clinical Randomized Control Trial

Vittoria Carnevale Pellino, Alessandro Gatti, Matteo Vandoni, Pamela Patanè, Massimiliano Febbi, Stefania Ballarin, Caterina Cavallo, Luca Marin

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: leg pneumatic compression; total hip arthroplasty; lower limb edema

Online: 9 May 2023 (05:44:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0205.v1

Different Lower Extremity Arterial Calcification Patterns in Patients with Chronic Limb-Threatening Ischemia Compared with Asymptomatic Controls

Louise CD Konijn, Richard AP Takx, Willem PThM Mali, Hugo TC Veger, Hendrik van Overhagen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic limb-threatening ischemia; peripheral arterial disease; calcification pattern

Online: 7 April 2021 (14:45:17 CEST)

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Objectives The most severe type of peripheral arterial disease (PAD) is critical limb ischaemia (CLI). In CLI, calcification of the vessel wall plays an important role in symptoms, amputation rate and mortality. However, calcified arteries are also found in asymptomatic persons (non-PAD patients). We investigated whether the calcification pattern in CLI patients and non- PAD patients are different and could possibly explain the symptoms in CLI patients. Materials and Methods 130 CLI and 204 non-PAD patients underwent a CT of the lower extremities. This resulted in 118 CLI patients (mean age 72±12, 70.3% male) that were age-matched with 118 non-PAD patients (mean age 71±11, 51.7% male). The characteristics severity, annularity, thickness and continuity were assessed in the femoral and crural arteries and analysed by binary multiple logistic regression. Results Nearly all CLI patients have calcifications and these are equally frequent in the femoropopliteal (98.3%) and crural arteries (97.5%), while the non-PAD patients had in just 67% any calcifications with more calcifications in the femoropopliteal (70.3%) than in the crural arteries (55.9%, p<0.005). The crural arteries of the CLI patients had significantly more complete annular calcifications (OR 2.92, p=0.001.) while in the non-PAD patients dot-like calcifications dominated. In CLI patients, the femoropopliteal arteries had more severe, irregular / patchy and thick calcifications (OR 2.40, 3.27, 1.81, p≤0.05, respectively) while in non-PAD patients, thin continuous calcifications prevailed. Conclusions Compared with non-PAD patients CLI patients are more frequently and extensively calcified. Annular calcifications were found in the crural arteries of CLI patients while dot-like calcifications were mostly present in the non-PAD patients. These different patterns of calcifications in CLI point at different etiology and can have prognostic and eventually therapeutic consequences.

Preprint REVIEW | doi:10.20944/preprints201901.0293.v1

The Homuncular Jigsaw: Investigations of Phantom Limb and Body Awareness Following Brachial Plexus Block or Avulsion

Mariella Pazzaglia, Erik Leemhuis, Anna Maria Giannini, Patrick Haggard

Subject: Social Sciences, Behavior Sciences Keywords: phantom limb, somatotopy, brachial plexus, deafferentation rehabilitation, anesthetic block.

Online: 29 January 2019 (09:46:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0945.v1

The Effect of Cerium Oxide (CeO2) on Ischemia-Reperfusion Injury in Skeletal Muscle in Mice with Streptozocin-Induced Diabetes

Abdullah Özer, Necmiye Şengel, Ayşegül Küçük, Zeynep Yığman, Çağrı Özdemir, Yiğit Kılıç, Ali Doğan Dursun, Hasan Bostancı, Gülay Kip, Mustafa Arslan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: diabetes mellitus; cerium oxide; skeletal muscle; lower limb; ischemia-reperfusion

Online: 19 February 2024 (14:12:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1383.v1

Test-Retest Repeatability of Human Gestures in Manipulation Tasks

Elisa Digo, Elena Caselli, Michele Polito, Mattia Antonelli, Laura Gastaldi, Stefano Pastorelli

Subject: Engineering, Mechanical Engineering Keywords: Industry 5.0; MIMUs; collaborative robotics; upper limb; human-machine interaction

Online: 20 June 2023 (03:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1704.v1

Active Device for Shoulder Rehabilitation Based on Force Control

Isabel M. Alguacil-Diego, Alicia Cuesta-Gómez, David Pont-Esteban, Juan Carrillo-Rios, Paul Espinosa-Peralta, Miguel Ángel Sánchez-Urán, Manuel Ferré

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Force control; haptic; upper limb; rehabilitation; shoulder movements; medical rehabilitation

Online: 24 May 2023 (05:33:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0512.v1

Objective and Subjective Evaluation of a Passive Exoskeleton for Upper Limbs

Berenger Le Tellier, Thomas Albouy, Kevin Lebel

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: MSDs; exoskeleton; upper limb assistance; EMG; balance test; subjective questionnaire

Online: 26 November 2021 (18:09:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.0983.v1

Lanthanide Complexes with Tripodal Ligands

Kira E. Vostrikova

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: tripodal ligands; lanthanides; single-molecule magnets; single-ion magnets; axiality

Online: 14 June 2023 (04:47:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0103.v1

The Expected Competitive Ratio on a Kind of Stochastic-Online Followtime Scheduling with Machine Subject to an Uncertain Breakdown

Zhenpeng Li, Congdian Cheng

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: single machine; single breakdown; schedule; flowtime; stochastic optimization; online optimization

Online: 6 March 2023 (13:00:04 CET)

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Preprint REVIEW | doi:10.20944/preprints201911.0236.v1

A Tribute to Lewis Wolpert on the 50th Anniversary of the Publication of His Paper ‘Positional Information and the Spatial Pattern of Differentiation’. Evidence for a Timing Mechanism for Setting Up the Vertebrate Anterior-Posterior (A-P) Axis

Antony Durston

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Hox genes; limb development; main body axis; timing; time space translation

Online: 20 November 2019 (10:31:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0504.v1

Sparsely Connected Autoencoders: A Multi-Purpose Tool for Single Cell Omics Analysis

Luca Alessandri, Maria Luisa Ratto, Sandro Gepiro Contaldo, Marco Beccuti, Francesca Cordero, Maddalena Arigoni, Raffaele A. Calogero

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: single cell RNAseq; single cell ATACseq; sparsely connected autoencoder; pseudo-bulk

Online: 29 September 2021 (17:26:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0317.v1

Parental Burnout in the Context of Special Needs, Adoption, and Single Parenthood

Isabelle Roskam, Moïra Mikolajczak

Subject: Social Sciences, Psychology Keywords: exhaustion; disability; illness; disorder; adopted child; adoptive parent; single mom; single dad

Online: 5 June 2023 (12:07:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0744.v1

A Rapid Control Prototyping and Hardware-in-the Loop Approach for Upper Limb Robotic Exoskeletons Control

Giulia Bodo, Federico Tessari, Stefano Buccelli, Matteo Laffranchi

Subject: Engineering, Control And Systems Engineering Keywords: Rehabilitative Robotics; Compliant actuation; Robotic Control; Upper Limb Exoskeleton; Rapid Control Prototyping

Online: 13 February 2024 (12:26:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1523.v1

Topical Application of Autologous Leukocyte-Rich Platelet-Rich Plasma with a High Concentration of Monocytes in Patients with Recalcitrant Ischemic Diabetic Foot Ulcers: Efficacy, Safety and Economic Evaluation.

Benedetta Ragghianti, Giovanni Antonio Silverii, Bianca Maria Berardi, Linda Luppichini, Maria Masulli, Matteo Monami

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; Foot ulcer; Cell-therapy; Chronic Limb-Threatening Ischemia; Economic evaluation

Online: 20 December 2023 (10:18:08 CET)

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BACKGROUND: Patients with diabetic foot ulcers (DFU) and chronic limb-threatening ischemia (CLTI are at higher risk for major amputations and mortality. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of autologous monocyte-rich PRP platelet-rich plasma Tropocells® PRP (Estar Medical, Holon, Israel) in diabetic patients with chronic limb-threatening ischemia (CLTI) in which revascularization was not feasible. METHODS: a retrospective study was carried out on a series of patients with type 2 diabetes, grade Texas 3C or D DFU, and CLTI. All patients had undergone at least a previous revascularization and were allocated to a surgery waiting list for major amputation. According to the data provided by the manufacturer (https://www.zuccatobiotech.it/index.php/prodotti/tropocells), the monocyte-rich PRP kit obtained a platelet-rich plasma with a high concentration of peripheral blood mononuclear cells (with a proportionately lower amount of lymphocytes), a low concentration of neutrophils and an almost complete depletion of red blood cells. All patients underwent a procedure of local infiltration of autologous mononuclear cells through multiple perilesional and intramuscular injections of 10 mL PBMNC suspensions (0.2–0.3 mL in boluses) performed below the knee along the relevant vascular axis (anterior tibial artery and posterior tibial artery) at intervals of 1–2 cm and to a mean depth of 1.5–2 cm, using a 21 G needle. The procedures were performed according to the instructions of the manufacturer and were repeated at least two times (maximum 3 times) at intervals of 30 days. The principal endpoint was a composite of TcPO2 values at the first toe ≥30 mmHg and/or TcPO2 increase of at least 50% from baseline and/or ulcer healing. Secondary endpoints were individual components of the primary endpoint, quality of life, any adverse events, and direct costs. All the endpoints were evaluated at 26 weeks. RESULTS: Out of 21 enrolled patients, 13 (61.9%) reached the primary endpoint, whereas three patients underwent a major amputation, and two patients died. The median TpCO2 was significantly increased, and pain was significantly reduced. The overall mean and median cost per patient were 9,255±7,328€ and 4,001 [2,991;7,565]€, respectively. CONCLUSIONS: the use of PBMNCs implants in patients with DFU and no-option CLTI seems to be efficacious in reducing the risk of major amputation and improve ulcer healing.

Preprint REVIEW | doi:10.20944/preprints202312.0244.v1

Translational Relevance of Advanced Age and Atherosclerosis in Preclinical Trials of Biotherapies for Peripheral Artery Disease

Keith A Webster

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: gene therapy; cell therapy; peripheral artery disease; critical limb ischemia; clinical trials

Online: 5 December 2023 (14:44:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1684.v3

Reference Values for the Grocery Shelving Test among United Arab Emirates Population: A Cross Sectional Study

Gopala Krishna Alaparthi, Aishwarya Prabhakar Gatty, Huda Isa, Latifa Hassan, Noura Khalid, Abdullah Osman, Sara Mahmoud, May Tamim, Kalyana Chakravarthy Bairapareddy, Arthur De Sa Ferreira

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Arm elevation; Grocery Shelving Test; Functional assessment; Reference values; Upper limb activities

Online: 8 June 2023 (08:52:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1276.v1

A Concise Review of Single-Molecule Magnets, Carbon Nanotubes and Hybrids Between Them

Mudasir A Yatoo, Faiza Habib, Ahmad Husain, Sharique Ahmad, Zubair Ahmad

Subject: Chemistry And Materials Science, Inorganic And Nuclear Chemistry Keywords: Molecular magnetism; single-molecule magnets; carbon nanotubes; single-molecule magnets-carbon nanotubes hybrids.

Online: 19 June 2023 (03:38:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0318.v1

RepRapable Automated Open Source Bag Valve Mask-Based Ventilator

Aliaksei Petsiuk, Nagendra G. Tanikella, Samantha Dertinger, Adam Pringle, Shane Oberloier, Joshua Pearce

Subject: Medicine And Pharmacology, Other Keywords: ventilator; pandemic; ventilation; influenza pandemic; coronavirus; coronavirus pandemic; pandemic ventilator; single-limb; open source; open hardware; COVID-19; medical hardware; RepRap; 3-D printing; open source medical hardware; embedded systems; real-time operating system

Online: 26 June 2020 (17:25:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0741.v1

Advances in the Multi-Orthogonal Folding of Single Polymer Chains into Single-Chain Nanoparticles

Agustín Blazquez-Martín, Ester Verde-Sesto, Angel J. Moreno, Arantxa Arbe, Juan Colmenero, José A. Pomposo

Subject: Chemistry And Materials Science, Biomaterials Keywords: folding; interactions; single-chain nanoparticles

Online: 30 November 2020 (16:20:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0221.v1

Single Cell Analysis of ACE2 Expression Reveals the Potential Targets for 2019-nCoV

Yanyan Zhu, Miaomiao Jiang, Liang Gao, Xiaoyun Huang

Subject: Biology And Life Sciences, Virology Keywords: ACE2; single cell; 2019-nCoV

Online: 16 February 2020 (14:56:57 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0351.v1

Advances in Phototriggered Synthesis of Single-Chain Polymer Nanoparticles

Ester Verde-Sesto, Agustín Blázquez-Martín, José A. Pomposo

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: photochemistry; photofolding; single-chain nanoparticles

Online: 30 October 2019 (09:03:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0361.v1

Inconsistent Outcomes of Metabolic Surgery for Nonobese Patients with Type 2 Diabetes

Kyung Yul Hur

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: inconsistent outcomes; epithelial-mesenchymal crosstalk; altered identity; duodenal-jejunal bypass; biliopancreatic limb; GIP

Online: 21 March 2023 (01:36:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0396.v1

Feasibility Study of Cable Routing for Bi-Planar Trajectory Tracking in Cable Driven Lower Limb Exoskeleton

Rajan Prasad, Marwan El-Rich, Mohammad I. Awad, Sunil K. Agrawal, Kinda Khalaf

Subject: Engineering, Mechanical Engineering Keywords: cable driven; exoskeleton; lower limb rehabilitation; hip adduction; bi-planar trajectory; optimized routing.

Online: 26 October 2022 (03:54:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0083.v1

On the Role of Robotic Assistance in Upper-Limb Neurorehabilitation

Aravind Nehrujee, Sujatha Srinivasan, Sivakumar Balasubramanian

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: robotic assistance; Hebbian learning; sensorimotor recovery; upper-limb rehabilitation; stroke; re-habilitation robots

Online: 6 June 2022 (10:08:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0020.v1

Skeletal Muscle Cells Derived from Induced Pluripotent Stem Cells: A Platform for Limb Girdle Muscular Dystrophies

Celine Bruge, Marine Geoffroy, Manon Benabides, Emilie Pellier, Jamila Dhiab, Evelyne Gicquel, Lucile Hoch, Isabelle Richard, Xavier Nissan

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: limb girdle muscular dystrophies; induced pluripotent stem cells; skeletal muscle cells; pathological modeling

Online: 5 May 2022 (03:44:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0974.v1

Early Single Center Experience of DaVinci^® Single-Port (SP) Robotic Surgery in Colorectal Patients

Hye Jung Cho, Woo Ram Kim

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: colorectal neoplasm; robotic surgery; single-port

Online: 16 April 2024 (02:50:07 CEST)

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Background DaVinci Single-Port (SP) robotic surgery offers several benefits compared to traditional multiport laparoscopic or robotic surgeries. One of the main advantages is that it allows for a minimally invasive approach, resulting in a single, smaller incision and reduced trauma to the patient’s body leading to less postoperative pain, faster recovery, and reduced risk of complications. The cosmesis of a single port with minimal visible scarring is also an attractive aspect to the patients; however, many surgeons use an additional port for energy device, stapler use, and drain insertion. Pure single port surgery with one incision is still rare. Here we share our experience of first 10 cases using SP robotic platform in colorectal surgery. Methods From May 2023 to December 2023, colorectal patients who underwent SP-robotic surgery were analyzed. Placement of the incision was umbilicus for 8 patients, and right lower quadrant for 2 patients through which ileostomy maturation was performed. Data including perioperative parameters and postoperative outcomes were analyzed with a median follow-up of 4.6months (range 0.6-7.4months). Results A total number of 10 colorectal patients underwent DaVinci Single-Port robotic colorectal surgery at our institution during this period. Demographics of the patients showed 4 males (40%) and 6 females (60%) with a median age of 63.5years (range 50-75years). Median body mass index (BMI) was 22.89kg/m2 (range 19.92-26.84kg/m2), and 9 patients were diagnosed with colorectal cancer and 1 patient was diagnosed with rectal gastrointestinal tumor. One patient underwent anterior resection and cholecystectomy simultaneously. Mean operation time was 222min (range 142-316min), and mean wound size was 3.25cm (range 2.5-4.5cm). Nine patients underwent surgery with single incision through which single port trocar was inserted, and one patient had one additional port for drain insertion. Mean hospital stay was 6 days (range 4-8 days) with 1 postoperative complication of bleeding requiring transfusion, but there was no re-admission within 30 days. Conclusion Overall, our experience with single-port robotic colorectal surgery has been promising. With only one patient with additional port for drain insertion, all nine patients underwent SP-robotic surgery with single incision for colon as well as rectal surgeries. Compared to an average postoperative length of stay of 6.5-8 days in laparoscopic colorectal surgeries reported in literature, SP-robotic surgery showed faster recovery of 6 days highlighting its benefits in patient recovery and satisfaction.

Preprint ARTICLE | doi:10.20944/preprints202311.0280.v1

Optimizing Saffron (Crocus sativus) Yield and Quality through Nutrient Inputs and Timing: Insight from a Study in Lebanon

Abdel kader Amin El Hajj, Abir Chamandy, Faten Sayour, Sara Jaber, Nadine Oueidat

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Saffron; single administration dose; Fertilization; Crocin

Online: 6 November 2023 (13:38:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1070.v1

Association of Genetic Polymorphisms with Longevity in the population of the Sardinian Blue Zone

Alessandra Errigo, Maria Pina Dore, Giovanni Mario Pes

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: human longevity; single nucleotide polymorphisms; Sardinia

Online: 18 September 2023 (07:02:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0151.v1

Epididymis May Be More Important in Male Fertility than Our Cognition

Meng-Meng Liu, Hao Shang, Xin-Lei Feng, Chao Qi, Shu-Er Zhang, Yuan-Chao Sun, Chun-Yang Gou, Yu-Jiang Sun, Guo-Liang Zhang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Epididymis; Regional; Single cell/Spatial Transcriptomics

Online: 3 May 2023 (12:43:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0090.v1

Strong Coupling between A Single Quantum Emitter and a Plasmonic Nanoantenna on a Metallic Film

Shun Cao, Yuwei Sun, Zhenchao Liu, Sailing He

Subject: Physical Sciences, Optics And Photonics Keywords: strong coupling; nanoantenna; single quantum dot

Online: 7 March 2022 (07:49:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0207.v1

SMARTdenovo: A de novo Assembler Using Long Noisy Reads

Hailin Liu, Shigang Wu, Alun Li, Jue Ruan

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: SMARTdenovo; single-molecule sequencing; genome assembly

Online: 9 September 2020 (10:48:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0518.v1

The Association of RNF34 3′UTR-588 G>A and RNF128 I1-2380C>T with Carcass and Meat Quality Traits of Chinese Simmental-cross Steers

Azher Nawaz, JunZheng Zhang, Sihan Wang, Tian Quan, Chunyin Geng, YINGHAI JIN, Shuang Ji

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Cattle; RNF128; RNF34; Single nucleotide polymorphisms

Online: 24 August 2020 (09:44:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0099.v1

Artificial Intelligent Image Recognition System for Preventing Wrong Side Upper Limb Surgery

Yi-Chao Wu, Chao-Yun Chang, Yu-Tse Huang, Sung-Yuan Chen, Cheng-Hsuan Chen, Hsuan-Kai Kao

Subject: Engineering, Bioengineering Keywords: Intelligent Image Recognition; Left and Right Upper Limb Dislocation Surgery; Accuracy Rate; Recall Rate; IRB

Online: 3 October 2023 (09:17:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0290.v1

Intelligent Image Recognition System for Preventing Wrong Side Upper Limb Surgery

Yi-Chao Wu, Chao-Yun Chang, Yu-Tse Huang, Sung-Yuan Chen, Cheng-Hsuan Chen, Hsuan-Kai Kao

Subject: Engineering, Bioengineering Keywords: Intelligent Image Recognition; Left and Right Upper Limb Dislocation Surgery; Accuracy Rate; Recall Rate; IRB

Online: 5 September 2023 (09:20:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0684.v1

The Isokinetic Method in Female Uninjured Female Soccer Players: A Survey of Applications and Common Mismatches

Antonio Cicchella, Cheng Zhang

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: Female soccer; isokinetics; hamstring/quadriceps ratio; dominant non dominant limb ratio; errors in isokinetic dynamometry

Online: 9 June 2023 (08:17:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1171.v1

Topical Application of Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers: Efficacy, Safety and Economic Evaluation

Benedetta Ragghianti, Bianca Maria Berardi, Edoardo Mannucci, Matteo Monami

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; Foot ulcer; Cell-therapy; Small Artery Disease; Chronic Limb-Threatening Ischemia; Economic evaluation

Online: 17 May 2023 (02:41:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202008.0451.v1

The Molecular Interactome of the Centriole, Cell Cycle and Ciliary Proteins Modulates Cell Mass Growth and Structural Organization During Development in Metazoans

Roopasree OJ, Adivitiya ., Soura Chakraborty, Suneel Kateriya, Shobi Veleri

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Metazoa; body plan; developmental pathways; limb development; Shh; centriole; cell division; cilia; centriole gene expression

Online: 20 August 2020 (09:49:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0371.v1

Nuclei on the Rise: When Nuclei-Based Methods Meet Next-Generation Sequencing

Tamer Butto, Kanak Mungikar, Peter Baumann, Jennifer Winter, Beat Lutz, Susanne Gerber

Subject: Medicine And Pharmacology, Hematology Keywords: Nuclei isolation; Next-generation sequencing; Cell-type specific isolation; Epigenetics; Transcriptomics; Single cell sequencing; Single nucleus sequencing

Online: 21 March 2023 (06:40:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1843.v1

Passivation of Defective States in Single Crystal MAPbBr3 and Their Optoelectronic Properties Study

Hui Li, Jin Wang, Haitao Li, Zhi Guo, Zhenhua Chen

Subject: Physical Sciences, Applied Physics Keywords: single crystal; perovskite; synchrotron; MAPbBr3; optical property

Online: 28 August 2023 (09:52:48 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202306.2148.v1

The Homoleptic Curcumin-Copper Single Crystal (ML2): A Long Awaited Cherry on the Cake in the Field of Curcumin Metal Complexes

Antonino Arenaza Corona, Marco A. Obregón Mendoza, William Meza Morales, María Teresa Ramírez Apan, Antonio Nieto Camacho, Rubén A. Toscano, Leidys L. Pérez González, Rubén Sánchez Obregón, Raúl G. Enríquez

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Curcumin-Copper (II); single crystal; cytotoxicity; antioxidant

Online: 29 June 2023 (13:26:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1079.v1

Virtual Screening of Different Subclasses of Lignans with Anticancer Potential and Based on Genetic Profile

Mayara dos Santos Maia, Francisco Jaime Bezerra Mendonça-Junior, Gabriela Cristina Soares Rodrigues, Adriano Soares da Silva, Niara Isis Pereira de Oliveira, Pablo Rayff da Silva, Cícero Francisco Bezerra Felipe, Ana Pavla Almeida Diniz Gurgel, Anuraj Nayarisseri, Marcus Tullius Scotti, Luciana Scotti

Subject: Medicine And Pharmacology, Pharmacy Keywords: lignans; cancer; single nucleotide polymorphisms; virtual screening

Online: 16 June 2023 (05:10:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1104.v1

Elucidating the Role of Immune Cell Dysregulation in Atypical Hemolytic Uremic Syndrome: A Comprehensive Single-Cell Sequencing Analysis

I-Ru Chen, Chiu-Ching Huang, Siang‑Jyun Tu, Guei-Jane Wang, Ping-Chin Lai, Ya-Ting Lee, Ju-Chen Yen, Ya-Sian Chang, Jan‑Gowth Chang

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: hemolytic uremic syndrome; complement; single cell sequencing

Online: 16 May 2023 (05:36:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0476.v1

Optimization of a Single Ion Heat Engine for Adiabatic Processes at High and Low Temperature Limits

Abdi Belina Atomsa, Tolasa Adugna Dima

Subject: Physical Sciences, Applied Physics Keywords: Adiabatic; figure of merit; Heat engine; Single

Online: 26 December 2022 (06:50:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0135.v1

The Translocator Protein (TSPO) Genetic Polymorphism A147T is Associated with Worse Survival in Male Glioblastoma Patients

Katie M. Troike, Arlet M Acanda De La Rocha, Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Gino Cioffi, Kristin A. Waite, Jill S. Barnholtz-Sloan, Justin D. Lathia, Tomas R. Guilarte, Diana J. Azzam

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Glioblastoma; biomarker; TSPO; single nucleotide polymorphism; survival.

Online: 5 August 2021 (10:22:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0613.v1

“Clickase” Single-Chain Nanoparticles: Effect of Intra-Chain Distribution of Catalytic Sites on Catalytic Activity

Isabel Asenjo-Sanz, Tatiana Claros, Edurne González, Ester Verde-Sesto, José A. Pomposo

Subject: Chemistry And Materials Science, Biomaterials Keywords: folding; single-chain nanoparticles; catalysis; click chemistry

Online: 29 January 2021 (11:51:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0498.v1

Fermentation Optimization for Actinomycetes as a Single Cell Protein: A Comprehensive Review

Hayat Ullah, Asad Ullah, Muhammad Waseem Khan

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: single cell protein; probiotic; actinomycetes; fermentation optimization

Online: 28 April 2020 (10:49:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0142.v1

Single-Molecule Dynamics and Discrimination between Hydrophilic and Hydrophobic Amino Acids in Peptides, through Controllable, Stepwise Translocation across Nanopores

Alina Asandei, Isabela S. Dragomir, Giovanni Di Muccio, Mauro Chinappi, Yoonkyung Park, Tudor Luchian

Subject: Chemistry And Materials Science, Nanotechnology Keywords: nanopore; peptide sensing; electrophysiology; single-molecule sequencing

Online: 9 July 2018 (13:26:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0155.v1

Fracture Failure Mechanisms of Long Single PA6 Fibers

Huiling Ding, Yongzhen Zhang, Zhitao He

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: single fiber; cutting; fracture morphology; failure mechanism

Online: 22 May 2017 (05:29:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1188.v1

Reappraisal of Duodenal Exclusions and Biliopancreatic Limb Length in Metabolic Surgery for Nonobese Patients with Type 2 Diabetes

Kyung Yul Hur

Subject: Medicine And Pharmacology, Surgery Keywords: metabolic surgery; type 2 diabetes; postoperative hyperglycemia; duodenal exclusion; biliopancreatic limb length; altered epithelial identity; GIP

Online: 19 September 2023 (03:49:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0193.v1

Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia

Frantisek Jaluvka, Peter Ihnat, Juraj Madaric, Vaclav Prochazka

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cell therapy, Peripheral arterial disease, Bone marrow, Adipose tissue, Mesenchymal stem cells, Exosome, Critical limb ischemia.

Online: 4 November 2020 (12:37:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0266.v1

Effect of Fiber Sizing Levels on the Mechanical Properties of Carbon Fiber Reinforced Thermoset Composites

Albraa A. Jaber, Sara Abbas, Abdiaziz A. Farah, Karina Kopec, Yahya Al-Salik, Mohammed Tayeb, Nikhil Verghese

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: Carbon fiber; thermoset; sizing; single fiber tensile testing; single fiber pullout testing; sizing levels; X-ray photoelectron spectroscopy (XPS)

Online: 3 August 2023 (10:52:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0773.v1

Identification and Functional Analysis of Transcriptome Profiles, Long Non-coding RNAs, Single-Nucleotide Polymorphisms, and Alternative Splicing from the Oocyte to the Preimplantation Stage of Sheep by Single-Cell RNA Sequencing

Zi Jing Zhang, Qiao ting Shi, Xiao ting Zhu, Lei Jin, Li min Lang, Shi jie Lyv, Xiao ling Xin, Yong zhen Huang, Xiang Yu, Zhi ming Li, Su Juan Chen, Zhao xue Xu, Wei Zhang, Er yao Wang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Key words: transcriptome profiles; long non-coding RNAs; single-nucleotide polymorphisms; alternative splicing; sheep; preimplantation; Single-cell RNA sequencing

Online: 23 April 2023 (04:57:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1235.v1

Patient’s Healthy Limb Motion Characteristics Based Assist-as-Needed Control Strategy for Upper-Limb Rehabilitation Robot

Bingjing Guo, Zhenzhu Li, Mingxiang Huang, Xiangpan Li, Jianhai Han

Subject: Engineering, Mechanical Engineering Keywords: upper-limb rehabilitation robot; assist-as-needed control; endpoint stiffness estimation; stiffness mapping algorithm; surface electromyographic signal

Online: 16 January 2024 (12:33:07 CET)

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The implementation of a progressive rehabilitation training model to promote patients’ motivation efforts can greatly restore the damaged central nervous system function in patients. The patients’ active engagement can be effectively stimulated by assist-as-needed (AAN) robot rehabilitation training. However, its application in robotic therapy has been hindered by a simple determination method of robot assisted torque which focuses on the evaluation only of the affected limb's movement ability. Moreover, the expected effect of assistance depends on the designer, which deviates from the patient's expectations, and its applicability to different patients is deficient. In this study, we propose a control method with personalized treatment features based on the idea of estimating and mapping the stiffness of the patient’s healthy limbs. This control method comprises an interactive control module in the task-oriented space based on the quantitative evaluation of motion needs and an inner loop position control module for the pneumatic swing cylinder in the joint space. An upper limb endpoint stiffness estimation model is constructed and a parameter identification algorithm is designed. The upper limb endpoint stiffness which characterizes the patient's ability to complete training movements is obtained by collecting surface electromyographic (sEMG) signals and human-robot interaction forces during patient movement. Then the motor needs of the affected limb when completing the same movement are quantified based on the performance of the healthy limb. A stiffness mapping algorithm is designed to dynamically adjust the rehabilitation training trajectory and auxiliary force of the robot based on the actual movement ability of the affected limb, achieving AAN control. Experimental studies were conducted on a self-developed pneumatic upper limb rehabilitation robot, and the results showed that the proposed AAN control method can effectively estimate the patient's movement needs and achieve progressive rehabilitation training. The rehabilitation training robot that simulates the movement characteristics of the patient's healthy limbs drives the affected limb, making the intensity of the rehabilitation training task more in line with the patient's pre-morbid limb use habits, and also beneficial for the consistency of bilateral limb movements.

Preprint ARTICLE | doi:10.20944/preprints202310.0965.v1

Clinical Efficacy of Antibiotic Bone Cement plus Lateral Bone Repositioning for Severe Diabetic Foot and Its Impact on Wound Healing Rate

Fangcheng Luo, Lei Zhang, Hong Cao, Rongzhi Wen, Wei Shang, Xinhua Cheng

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Diabetic foot; Severe disease; Antibiotic bone cement; Lateral bone repositioning; Lower limb function; Dorsalis pedis artery hemodynamics

Online: 16 October 2023 (15:42:17 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.0607.v2

A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters

Spyros Papageorgiou

Subject: Biology And Life Sciences, Biophysics Keywords: Hox gene collinearity; temporal collinearity; Noether theory; self similarity; double strand break; split Ηox cluster; limb growth

Online: 11 May 2023 (04:34:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1262.v1

Role of Il-6, IL-10 and TNFα Gene Variants in Preterm Birth

Mirta Kadivnik, Deni Plečko, Kristina Kralik, Nena Arvaj, Jasenka Wagner

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: premature birth; single nucleotide polymorphisms; inflammation; cytokines; interleukins

Online: 21 March 2024 (08:57:59 CET)

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Introduction: The association of gene variants for interleukin 6(IL-6) (rs1800796), interleukin 10 (IL-10) (rs1800896) and tumor necrosis factorα (TNFα (rs1800629) with the occurrence of spontaneous preterm birth (PTB) was investigated to determine whether these genetic variants are a risk factor. Materials and methods: 199 blood samples from pregnant women who had given birth prematurely and 200 control blood samples were analyzed to determine single nucleotide polymor-phisms (SNPs) of genes for IL-6 (rs1800796), IL-10 (rs1800896) and TNFα (rs1800629). The control samples were samples from pregnant women with term delivery. Isolation of DNA was per-formed on mini-spin columns according to the manufacturer's protocol. The quality and purity of the isolated DNA were tested using a Qubit 3 fluorometer. Genotyping was performed with an ABI PRISM 7500 SDS using TaqMan SNP genotyping assays. The genotypes obtained were an-alyzed using the 7500 Software v2.3 package. Results: Carriers of the A/A genotype for the rs1800629 of the TNFα gene have 4.81 times greater chance of late-onset PTB compared to carriers of the G/G and A/G genotypes in the recessive inheritance model. The presence of the G/G genotype in the recessive inheritance model compared with the G/A and A/A genotypes for the rs1800896 of the IL-10 gene represents a potentially protective factor, with mothers in the term-birth group having an almost 2-fold lower odds of PTB in general and an almost 10-fold lower odds of early PTB. On the other hand, carriers of the A/G genotype of rs1800896 have a 1.54-fold higher chance of preterm birth in general and a 1.6-fold higher chance of late preterm birth in the super dominant inheritance model compared to the A/A and G/G genotypes in the group of mothers with PTB. In this study, no association was found between PTB and rs1800796 of the IL-6 gene. Conclusion: rs1800629 in mothers was associated with PTB. rs1800896 shows a potentially protective effect for the occurrence of PTB in this study. No association was found between PTB and rs1800796.

Preprint REVIEW | doi:10.20944/preprints202401.1659.v1

Juvenile Delinquency as a Contemporary Issue in Nigeria: Unraveling the Impact of Parenting Styles and Family Structures

Sunkanmi Folorunsho, Victor Ajayi, Oluwakemi Abdulrazaq

Subject: Social Sciences, Sociology Keywords: Adolescent; Family; Juvenile Parent; Children; Delinquency; Single Parenting

Online: 23 January 2024 (07:44:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0532.v1

Evaluating a 3D Ultrasound Imaging Resolution of Single Transmitter/Receiver with Coding Mask by Extracting Phase Information

Mohammad Syaryadhi, Eiko Nakazawa, Norio Tagawa, Ming Yang

Subject: Computer Science And Mathematics, Signal Processing Keywords: single transducer; coding mask; frequency subband compound; SCM

Online: 7 December 2023 (14:32:26 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.1266.v1

Asymmetric Dual-Grating Dielectric Laser Accelerator Optimization

Sophie Crisp, Alexander Ody, Pietro Musumeci

Subject: Physical Sciences, Other Keywords: DLA; Dielectric Laser Accelerator; Dual Grating; Single Drive

Online: 19 October 2023 (11:04:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1833.v1

R-PreNet: Deraining Network Based on Image Background Prior

Congyu Jiao, Fanjie Meng, Tingxuan Li, Ying Cao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: single image deraining; residual channel prior; interactive fusion

Online: 27 September 2023 (05:38:23 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202309.1293.v1

Multispectral SNSPD Using Modified Distributed Bragg Reflector, Gold Mirror, and Multilayer-Nanowire Structures

Ping-Han Wu, Hsin-Yeh Wu, Stathes Paganis

Subject: Physical Sciences, Optics And Photonics Keywords: SNSPD; multispectral; dual-spectral; single photon; quantum communication

Online: 20 September 2023 (02:29:29 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202308.0079.v1

Influence of Different Evolutive Forces on GDF5 Gene Variability

Laura Flore, Paolo Francalacci, Myosotis Massidda, Renato Robledo, Carla Maria Calò

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Single nucleotide polymorphism, Population Branch Statistic, selective pressure.

Online: 1 August 2023 (10:37:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0164.v1

Laboratory Tests Using Distributed Fiber Optical Sensors to Validated a Future Field Application for Strain Monitoring Pile

Rodrigo Moraes Silveira, Marcelo Buras, André Luiz Delmondes Pereira Filho, Juliana Ferreira Fernandes, Marcos Massao Futai

Subject: Engineering, Civil Engineering Keywords: distributed fiber optics; tensile tests; single mode fiber

Online: 4 May 2023 (02:56:37 CEST)

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The use of fiber optics as a tool for different kinds of geotechnical monitoring can become highly attractive and cost effective when compared to conventional instruments such as piezometers, inclinometers, among others. A single fiber optic cable may cover a larger monitoring area compared to conventional instrumentation, and the possibility of monitoring more than one physical quantity with the same fiber optic cable. Consulting the literature, it is possible to find several different examples where distributed fiber optic systems are being used. For the use of any sensor, a calibration curve is required. In the case of strain sensors, calibration is required to derive strain values from the frequency measurement quantity. However, fiber optic sensor cable manufacturers often do not provide their own calibration parameters and consult the values in specialized literature, which can result in monitoring errors. In this context, this article presents a bench adjusted for tests on single mode fiber optic cables, as well as results of tensile tests aimed at defining the function of strain variations of two different optical fiber cables, manufactured by different companies, using two different distributed interrogators. This paper also proposes a methodology for calibrating of the fiber optic cables deformation since the calibration parameters are provided by the cable manufacturers, which can result in errors depending on the application. It should be noted that there are few manufacturers of fiber optic cables aimed at application in civil engineering. Therefore, with the calibration methodology proposed in this paper, it is intended to transmit to the academic community the possibility of obtaining calibration parameters of any fiber optic cable, even those manufactured for telecommunications purposes and not only for cables manufactured with the intended use in civil engineering. Because of this fact, researchers will not be restricted to the acquisition of special cables for their applications. Based on the results, it was possible to conclude that the application of calibrated fiber optic sensors in experimental piles foundations is viable, in order to evaluate the load-displacement behavior of these elements, under different loading conditions.

Preprint ARTICLE | doi:10.20944/preprints202205.0106.v1

Seepage Characteristics Study of Single Rough Fracture Based on Numerical Simulation

Shidong Wang, Qing Zhang, Li Zhao, Yi Jin, Jiazhong Qian

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: seepage characteristics; single fracture; roughness; numerical simulation; Fluent

Online: 9 May 2022 (06:13:55 CEST)

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Working Paper ARTICLE

Diffusivity Measurement by Single Molecule Recycling in a Capillary Microchannel

Bo Wang, Lloyd M. Davis

Subject: Physical Sciences, Acoustics Keywords: capillary; microfluidic device; single-molecule recycling; maximum likelihood

Online: 26 May 2021 (10:50:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0562.v1

Active and Stable MgAl₂O₄ and Ni(SA)/MgAl₂O4 Catalysts for the Reverse Water Gas Shift Reaction

Lingling Zhang, Qi Song, Yimeng Xing, Zhichun Si, Yuxiang Liu, Rui Ran, Xiaodong Wu, Duan Weng, Feiyu Kang

Subject: Chemistry And Materials Science, Biomaterials Keywords: MgAl2O4, Single atomic Nin+, RWGS, Stability, Reaction mechanism

Online: 24 May 2021 (10:50:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0704.v2

Improving Absorption in Single Silicon Nanowires by Symmetry-breaking Design from Square to Rectangular Cross-section

Wenfu Liu

Subject: Chemistry And Materials Science, Biomaterials Keywords: single nanowires; Symmetry breaking; rectangular cross-section; absorption

Online: 8 February 2021 (11:38:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0712.v2

Light Trapping in Single Elliptical Silicon Nanowires

Wenfu Liu, Yinling Wang, Xiaolei Guo, Jun Song, Xiao Wang, Yasha Yi

Subject: Chemistry And Materials Science, Biomaterials Keywords: silicon; single nanowires; elliptical cross-section; absorption; photocurrent

Online: 19 October 2020 (15:58:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0596.v1

Monitoring HIV-1 Assembly in Living Cells: Insight from Dynamic and Single Molecule Microscopy

Kaushik Inamdar, Charlotte Floderer, Cyril Favard, Delphine Muriaux

Subject: Biology And Life Sciences, Virology Keywords: HIV-1 assembly, Gag, single molecule microscopy, dynamics

Online: 26 November 2018 (14:12:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0371.v1

Single Cell Isolation Using Optical Tweezers

Anusha Keloth, Owen Anderson, Donald Risbridger, Lynn Paterson

Subject: Physical Sciences, Applied Physics Keywords: optical tweezers; optical trap; PDMS devices; single cells

Online: 25 June 2018 (06:10:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0183.v1

The Structure of Ferroselite, FeSe₂, at Pressures Upto 46 GPa and Temperatures Down to 50 K: ASingle-Crystal Micro-Diffraction Analysis

Barbara Lavina, Robert T Downs, Stanislav Sinogeikin

Subject: Physical Sciences, Condensed Matter Physics Keywords: FeSe2; high pressure; low temperature; single crystal diffraction

Online: 12 June 2018 (10:25:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0129.v1

Crystal Growth Techniques for Layered Superconductors

Masanori Nagao

Subject: Physical Sciences, Condensed Matter Physics Keywords: single crystal growth; incongruent melting compound; flux method

Online: 26 September 2017 (12:04:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1355.v1

Atorvastatin Treatment Significantly Increased the Concentration of BM-MNCs and TcPO2 and Lowered Pain Scale after BMCs Treatment Patients with “No-Option” Critical Limb Ischaemia.

Jan Kyselovic, Adriana Adamickova, Andrea Gažová, Simona Valášková, Nikola Chomanicova, Zdenko Cervenak, Juraj Madaric

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Atorvastatin; Critical limb ischaemia; Bone marrow cell therapy; Mesenchymal stem cells; RAS-acting agents; Predictive analysis; Spearman correlation

Online: 22 March 2024 (06:27:04 CET)

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Background: The present study investigated the outcomes and possible predictive factors of autologous bone marrow cells (BMCs) therapy in patients with „no-option“ critical limb ischaemia (CLI). It was focused on exploring the clinical background and prior statin and renin-angiotensin system (RAS)-acting agent’s pharmacotherapy related to the therapeutic efficacy of BMCs treatment. Methods: In the present study, we have reviewed thirty-three patients (mean age 64.9 ± 10 years; 31 males) with advanced CLI after failed or impossible revascularisation, who were treated with 40 ml of autologous BMCs by local intramuscular application. Patients with limb salvage and wound healing (n=22) were considered responders to BMCs therapy, and patients with limb salvage and complete ischemic wound healing (n=13) were defined as super-responders. Logistic regression models were used to screen and identify the prognostic factors, and a receiver operating characteristics (ROC) curve, a linear regression and a survival curve were drawn to determine the predictive accuracy, the correlation between the candidate predictors and the risk of major amputation. Results: Based on the univariate regression analysis, baseline C-reactive protein (CRP) and transcutaneous oxygen pressure (TcPO2) values were identified as prognostic factors of the responders, while CRP value, ankle-brachial index (ABI) and bone marrow-derived mononuclear cells (BM-MNCs) concentration were identified as prognostic factors of the super-responders. An area under the ROC curve of 0.768 indicated good discrimination for CRP ˃ 8.1 mg/L before transplantation as a predictive factor for negative clinical response. Linear regression analysis revealed a significant dependence between the levels of baseline CRP and the concentration of BM-MNCs in transplanted bone marrow. Patients taking atorvastatin before BMCs treatment (n=22) had significantly improved TcPO2 and reduced pain scale after BMCs transplant, compared to the non-atorvastatin group. Statin treatment was associated with reduced risk for major amputation. However, the difference was not statistically significant. Statin use was also associated with a significantly higher concentration of BM-MNCs in the transplanted bone marrow compared to patients without statin treatment. Patients treated with RAS-acting agents (n=20) had significantly reduced pain scale after BMCs transplant, compared to the NON-RAS group. Similar results, reduced pain scale and improved TcPO2, were achieved in patients treated with atorvastatin and RAS-acting agents (n=17) before BMCs treatment. Results of the Spearman correlation showed a significant positive correlation between CLI regression, responders, and previous therapy before BMCs transplant with RAS-acting agents alone or with atorvastatin. Conclusions: CRP and TcPO2 were prognostic factors of the responders, while CRP value, ABI and BM-MNCs concentration were identified as predictive factors of the super-responders. Atorvastatin treatment was associated with a significantly increased concentration of BM-MNCs in bone marrow concentrate and higher TcPO2 and lower pain scale after BMCs treatment in CLI patients. Similarly, reduced pain scales and improved TcPO2 were achieved in patients treated with atorvastatin and RAS-acting agents before BMCs treatment. Positive correlations between responder and previous treatment before BMCs transplant with RAS-acting agents alone or atorvastatin were significant.

Preprint REVIEW | doi:10.20944/preprints202308.0175.v1

Review and Analysis of Platform-Related Performance of Rehabilitation Lower Limb Exoskeletons

Hossein Karami, Stefano Maludrottu, Christian Vassallo, Matteo Laffranchi, Lorenzo De Michieli

Subject: Engineering, Bioengineering Keywords: Powered lower limb exoskeletons; rehabilitation and assistance; performance criteria; neurological disorders; auxiliary devices; control strategies; effectiveness of PLLE

Online: 2 August 2023 (10:04:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1008.v1

Patient Reported Outcome Measures (PROMs) Amongst Lower Extremity Agonist-Antagonist Myoneural Interface (AMI) Amputees

Rachael B Chiao, Corey L Sullivan, Lori Berger, Tawnee L Sparling, Tracy L Landry, Kendall Clites, Matthew J Carty

Subject: Medicine And Pharmacology, Surgery Keywords: Transtibial amputation; transfemoral amputation; agonist-antagonist myoneural interface; AMI; proprioception; neural interface; functional limb restoration; patient reported outcomes

Online: 14 July 2023 (13:29:21 CEST)

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Background: The standard surgical approach to amputation has failed to evolve significantly over the past century. Consequently, standard amputations often fall short with regards to improving the quality-of-life (QoL) for patients. A modified amputation has been designed at both the transtibial (TTA) and transfemoral (TFA) level that incorporates agonist-antagonist myoneural interface (AMI) constructs to provide patients with a novel alternative to standard amputation. Here, we present the patient reported outcome measures (PROMs) amongst our lower extremity AMI amputees and demonstrate an overall significant improvement in their physical and mental wellbeing. Methods: Four PROMs surveys, 1) EQ-5D-3L, 2) Lower Extremity Functional Scale (LEFS), 3) PROMIS-57, 4) Short Form-36 (SF-36), and 5) Sickness Impact Profile (SIP), were administered to lower extremity AMI amputees pre-operatively (baseline) and at 6 weeks, 3 months, 6 months, 9 months, 12 months, 24 months, 36 months, and 48 months post-operatively between June 24th, 2018, and December 15th, 2022. The surveys were either administered during a clinic visit or emailed at the encounter timepoint. Study data was collected and managed using REDCap (Research Electronic Data Capture) electronic data capture tools hosted at Brigham and Women’s Hospital. Analyses of collated data were performed by fitting a linear mixed model using SAS version 9.4 (SAS Institute, Cary, NC). Results: The cohort’s baseline and 12-month post-operative responses were compared to determine score improvement. The cohort demonstrated a significantly improved EQ-5D-3L index value (p<0.0001) and EQ VAS (p<0.0001) at 12-months post-operatively (n=22) when compared to baseline (n=28). The LEFS score significantly improved at 12-months post-operatively compared to baseline (p<0.0001) with a mean of 59.04 ± 3.14 (SE) at 12-months and a mean of 31.96 ± 2.84 (SE) at baseline. AMI patients demonstrated significantly improved scores across PROMIS-57 domains at 12-months compared to baseline scores; the p-value was <0.0001 for all domains except for the Depression domain where p=0.0181. The health domain scores significantly improved from baseline to 12-months post-operation for all SF-36 domains. Lastly, the SIP indicated a significant decrease in overall dysfunction from baseline to 12-months post-operation (p<0.0001). Conclusions: Modified lower extremity amputation with AMI construction has the potential to provide amputees with increased quality-of-life when compared to the pre-operative state. However, further investigation is necessary to determine whether the patient reported outcome measures of the AMI amputee cohort are superior to those who receive a standard amputation.

Preprint ARTICLE | doi:10.20944/preprints202404.0154.v1

Towards Improving YARN performance for Frugal Heterogeneous SBC-based Edge Clusters

Basit Qureshi

Subject: Computer Science And Mathematics, Computer Science Keywords: Single Board Computers; Frugal edge computing; Hadoop; YARN; heterogeneous

Online: 2 April 2024 (09:14:06 CEST)

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In the dynamic landscape of sustainable computing, use of edge devices is paramount for reducing the need for large-scale centralized data centers. By processing data locally, edge devices minimize the energy-intensive computing in data centers, improving the overall performance, cost-effectiveness whereas reducing the environmental impact. Edge devices may constitute edge clusters composed of resource frugal Single Board Computers (SBC) such as Raspberry Pi etc. The small form-factor and energy efficiency of these computers makes them ideal for processing large data on the edge. Despite their potential, traditional Hadoop configurations struggle to optimize performance in heterogeneous SBC clusters due to disparities in computing resources. Consequently, we propose modifications to the Yet Another Resource Negotiator (YARN) scheduling mechanism to address these challenges. Our proposed changes include the introduction of a Frugality Index and an adaptiveConfig policy. The Frugality Index categorizes SBC nodes based on their capabilities, enabling intelligent resource allocation. The adaptiveConfig policy dynamically adjusts resource allocation in response to workload and cluster conditions, enhancing system efficiency. Additionally, we introduce a fetch_threshold for reduce tasks to improve task prioritization based on locality and data processing efficiency. We evaluate our approach using a 13-node SBC cluster and conduct experiments with CPU-intensive and IO-intensive Hadoop benchmarks. The results demonstrate significant performance improvements compared to native YARN settings, with execution times 4.7 times faster than the worst_native and 1.9 times faster than the best_native scenarios. Furthermore, the proposed adaptiveConfig policy implementing the frugality index and a fetch_threshold outperforms the native YARN by 5.86 times and 1.79 times in Terasort and wordcount executions respectively. Our findings underscore the effectiveness of our approach in managing the heterogeneous nature of SBC clusters and optimizing performance across various hardware configurations. The adaptive policies prove well-suited to the frugal SBC-cluster context, yielding enhanced outcomes and paving the way for sustainable big data processing initiatives.

Preprint ARTICLE | doi:10.20944/preprints202403.0475.v1

A Model for Generating Playlists based on Consumer Emotions

Josué Alexis Lugos Abarca

Subject: Business, Economics And Management, Other Keywords: Single Equation Model, Decision Theory, Microeconomics, Utility Function, Neuroeconomics

Online: 8 March 2024 (09:05:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0293.v1

A Utility Function for the Music Consumer Based on Emotions

Josué Alexis Lugos Abarca

Subject: Business, Economics And Management, Other Keywords: Single equation model; mathematical; expected utility theory; probability; neuroeconomics

Online: 6 March 2024 (10:13:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1281.v1

Single-Cell RNA Sequencing, Current Progresses and Future Perspectives

Getnet Molla Desta, Alemayehu Godana Birhanu

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Single cell RNA sequencing; Transcriptome; high-throughput; spatial transcriptomics

Online: 22 February 2024 (15:17:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2174.v1

Surviving the Storm: An Exploratory Analysis of Pandemic's Impact on Urban Single Mother Entrepreneurship

Abdullah Sallehhuddin Abdullah Salim, Norzarina Md Yatim, Salmi Md Zahid

Subject: Social Sciences, Urban Studies And Planning Keywords: microfinance; single mother entrepreneurs; empowerment; urban; pandemic COVID-19

Online: 31 January 2024 (07:59:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0446.v1

Bimetallic Single-Atom Catalyst for Enhancing Hydrogen Evolution Reaction

Mengyang Zhang, Keyu Xu, Ning Sun, Yanling Zhuang, Longlu Wang, Dafeng *Yan

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: bimetallic single-atom; characterization; catalytic mechanism; hydrogen evolution reaction

Online: 8 October 2023 (11:59:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2074.v1

Prevalence of RAF1 Aberrations in Metastatic Cancer Patients: A Real World Data

Sung Hee Lim, Jaeyun Jung, Jung Young Hong, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Kyoung-Mee Kim, Jeeyun Lee

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: RAF1 aberration; amplification; fusion; single nucleotide variants; RAF inhibitor

Online: 29 September 2023 (10:33:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0832.v1

Puppis: Hardware Accelerator of Single-Shot Multibox Detectors for Edge-Based Applications

Vladimir Vrbaski, Slobodan Josic, Vuk Vranjkovic, Predrag Teodorovic, Rastislav Struharik

Subject: Engineering, Electrical And Electronic Engineering Keywords: Hardware acceleration; Convolutional Neural Networks; Single-Shot Multibox Detector

Online: 10 August 2023 (10:25:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1799.v2

QTL Epistasis Plays a Role of Homeostasis on Heading Date in Rice

Lilong Huang, Jichun Tang, Bihuang Zhu, Guodong Chen, Leyi Chen, Suhong Bu, Haitao Zhu, Zupei Liu, Zhan Li, Lijun Meng, Guifu Liu, Shaokui Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Epistasis; Homeostasis; Single segment substitution line; Heading date; Rice

Online: 31 July 2023 (09:42:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0475.v1

The Local Coordination Effects on the Reactivity and Speciation of Active Sites in Graphene-Embedded Single-Atom Catalysts Over Wide pH and Potential Range

Milica S. Ritopečki, Ana S. Dobrota, Natalia V. Skorodumova, Igor A. Pašti

Subject: Chemistry And Materials Science, Nanotechnology Keywords: single-atom catalysts; graphene; activity; reactivity; stability; Pourbaix plots

Online: 25 November 2022 (10:06:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0129.v1

Gradient-Applied Weighted Loss for Details of 3D Shape in Single-View Reconstruction

Jiho Lee, Taehyeon Kim, Gihwan Lee, Yoonsik Choe

Subject: Engineering, Electrical And Electronic Engineering Keywords: 3D shapes; single-view reconstruction; gradient map; fine-grained

Online: 8 November 2022 (01:04:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0387.v1

Exponentially–Fitted Fourth–Derivative Single–Step Obrechkoff Method for Oscillatory/Periodic Problems

Ashiribo Senapon Wusu, Olusola Olabanjo

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Exponentially–fitted; Obrechkoff; Fourth–derivative; Oscillatory; Periodic; Single–step

Online: 28 June 2022 (12:50:23 CEST)

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