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Preprint ARTICLE | doi:10.20944/preprints202403.0245.v1

Deciphering the Diversity of Bacterial Transporters that Salvage Queuosine Precursors

Samia Quaiyum, Yifeng Yuan, Paul Kuipers, Maria Martinelli, Marshall Jaroch, Valérie De Crécy-Lagard

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Queuosine; queuine; transporter; tRNA; salvage; biogeography; phylogenomic

Online: 5 March 2024 (10:49:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1881.v1

Hospital Readmission of Patients with Diabetic Foot Ulcers: Prevalence, Causes and Outcomes

Marco Meloni, Aikaterini Andreadi, Valeria Ruotolo, Maria Romano, Ermanno Bellizzi, Laura Giurato, Alfonso Bellia, Luigi Uccioli, Davide Lauro

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetes; diabetic foot; hospital admission; limb salvage

Online: 27 June 2023 (10:18:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1485.v1

Multidisciplinary and Tailored Treatment of LABC in Progression during NAC: Case Report

Letizia Cuniolo, Marco Gipponi, Federica Murelli, Francesca Depaoli, Chiara Cornacchia, Simonetta Franchelli, Marianna Pesce, Elena Ronda, Stefano Picardi, Raquel Diaz, Daniele Friedman, Franco De Cian, Piero Fregatti

Subject: Medicine And Pharmacology, Surgery Keywords: Locally Advanced Breast Cancer (LABC); Progressive Disease (PD); Salvage Treatment (ST)

Online: 20 December 2023 (09:34:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.2015.v1

Clinical Efficacy and Openness to New Challenges of Low Dose Rate (LDR) Brachytherapy for Prostate Cancer

Manabu Kato, Shinichiro Higashi, Yusuke Sugino, Shinya Kajiwara, Shiori Tanaka, Goshi Kitano, Yasuhumi Yamashita, Yuji Ogura, Hiroyuki Tachibana, Takahiro Kojima, Takahiro Inoue

Subject: Biology And Life Sciences, Life Sciences Keywords: prostate cancer; brachytherapy; low dose rate brachytherapy, tri-modality therapy, salvage brachytherapy, focal brachytherapy

Online: 30 August 2023 (09:50:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1664.v1

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for Fast-Track Team-Based Approach

Giorgio Ventoruzzo, Giulia Mazzitelli, Umberto Ruzzi, Francesco Liistro, Alessia Scatena, Eugenio Martelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: peripheral arterial disease; critical limb ischemia; chronic limb-threatening ischemia; survival; mortality; limb salvage

Online: 25 August 2023 (02:41:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0854.v1

Pectoralis Major in Salvage Total Laryngectomy After Irradiation. Morbidity, Mortality, Functional and Oncological Results in a Referral Center in Egypt

Mahmoud Abdelghany, Ayman Amin, Emilia Degni, Claudia Crescio, Asem Elsani M.A. Hassan, Tarek Ftohy, Francesco Bussu

Subject: Medicine And Pharmacology, Otolaryngology Keywords: salvage total laryngectomy; radiotherapy; pectoralis major flap; pharyngocutaneous fistula; laryngeal cancer; surgical morbidity; organ preservation

Online: 12 June 2023 (15:54:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0235.v1

The Challenge of Converting “Failed Spinal Cord Stimulation Syndrome” Back to Clinical Success, Using SCS Reprogramming as Salvage Therapy, Through Neurostimulation Adapters Combined with 3D-Computerized Pain Mapping Assessment. A Real-Life Retrospective Cohort Analysis

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Tania Banor, France Héroux, Manuel Roulaud, Etienne Babin, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Nihel Adjali, Kevin Nivole, Mathilde Many, Elodie Charrier, Delphine Rannou, Laure Poupin, Chantal Wood, Romain David, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Spinal Cord Stimulation; rescue therapy; salvage therapy; new waveforms; paresthesia-free waveforms; High-Frequency stimulation; Burst stimulation; spatial neural targeting; temporal neural targeting; SCS programming; adapter; mapping software; paresthesia coverage; patient outcome; salvage algorithm

Online: 18 October 2021 (10:04:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2044.v1

The Use of Salvage Chemotherapy for Patients with Relapsed Testicular Germ Cell Tumor (GCT) in Canada: A National Survey

Esmail M. Al-Ezzi, Amer Zahralliyali, Aaron R. Hansen, Robert J. Hamilton, Michael Crump, John Kuruvilla, Lori Wood, Lucia Nappi, Christian K. Kollmannsberger, Scott A. North, Eric Winquist, Denis Soulières, Sebastien J. Hotte, Di Maria Jiang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: relapsed germ cell tumors; salvage chemotherapy; conventional dose chemotherapy; high dose chemotherapy; autologous stem cell transplant

Online: 30 May 2023 (04:48:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0031.v1

The Added Value of Subcutaneous Peripheral Nerve Field Stimulation Combined with SCS, as Salvage Therapy, for Refractory Low Back Pain Component in Persistent Spinal Pain Syndrome Implanted Patients: A Randomized Controlled Study (CUMPNS Study) Based on 3D-Mapping Composite Pain Assessment

Philippe Rigoard, Amine Ounajim, Lisa Goudman, Benedicte Bouche, Manuel Roulaud, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Elodie Charrier, Delphine Rannou, Laure Poupin, Chantal Wood, Romain David, Dylan Héraud, Maarten Moens, Maxime Billot

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: spinal cord stimulation (SCS); peripheral nerve field stimulation (PNfS); SubQ-stimulation; hybrid stimulation; multidimensional pain assessment; pain mapping; pain software; persistent spinal pain syndrome - T2 (PSPS-T2); failed back surgery syndrome; failed spinal cord stimulation syndrome (FSCSS); salvage therapy; salvage algorithm

Online: 1 September 2021 (18:16:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0068.v1

Defining an Optimal Time Window for Salvage Surgery: Primary Radiochemotherapy Does Not Induce Radiomically Assessable Short-Term Alterations of Skeletal Muscle Composition in Head and Neck Squamous Cell Carcinoma

Matthias Santer, Herbert Riechelmann, Benedikt Hofauer, Joachim Schmutzhard, Wolfgang Freysinger, Annette Runge, Timo Gottfried, Philipp Zelger, Gerlig Widmann, Hanna Kranebitter, Stephanie Mangesius, Julian Mangesius, Florian Kocher, Daniel Dejaco

Subject: Medicine And Pharmacology, Otolaryngology Keywords: head and neck neoplasms; head and neck cancer; head and neck squamous cell carcinoma; radiotherapy; radiochemotherapy; salvage surgery; time interval; body composition; skeletal muscle; computed tomography scan; radiomics

Online: 4 September 2023 (02:41:55 CEST)

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Patients with locally advanced head and neck squamous cell carcinoma (HNSCC) frequently require primary radiochemotherapy (RCT). Despite intensity-modulation, desired radiation-induced effects observed in HNSCC, may also be observed as side-effects in healthy tissue e.g. the sternocleidomastoideus muscle (SCM). These side-effects (e.g. tissue fibrosis) depend on the interval between completion of RCT and restaging-CT. For salvage surgery, the optimal time window for surgery is currently postulated between 6 and 12 weeks after completion of RCT. Thus, no extensive tissue fibrosis is to be expected. This interval is based on studies exploring surgical complications. Studies directly exploring radiation-induced changes of the SCM in HNSCC-patients are sparse. The present study quantifies tissue alterations in SCM and paravertebral musculature (PVM) after RCT applying radiomics to determine the optimal time window for salvage surgery. Three radiomic key parameters 1) volume, 2) mean positivity of pixels (MPP) and 3) uniformity were extracted with mint lesionTM in the staging-CTs and restaging-CTs of 98 HNSCC-patients. Of these, 25 were female, the mean age was 62 (±9.6) years and 80.9% were UICC Stage IV. The mean restaging-interval was 55 (±28; range29-229) days. Only the mean volume significantly decreased after RCT from 9.0 to 8.4 and 96.5 to 91.9 ml for SCM and PVM, respectively (both p=0.007, both Cohen’s d=0.28). In addition, the mean body mass index (BMI) decreases from 23.9 (±4.2) to 21.0 (±3.6) kg/m² (p<0.001); Cohen's d = 0.9). The mean BMI-decrease significantly correlated with the volume decrease for SCM (r=0.27; p=0.007) and PVM (r=0.41; p<0.001). If t-test p-values were adjusted for the BMI-decrease, no significant change in volumes for SCM and PVM was observed (both p>0.05). The present data supports the postulated optimal interval for salvage surgery of 6 to 12 weeks. Irrespective of the remaining risk-benefit ratio of salvage surgery, the risk of additional surgical complications due to fibrosis is not supported by the present observations.

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