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Preprint ARTICLE | doi:10.20944/preprints202311.1162.v1

Factors Influencing Postoperative Outcomes in Children with Ureteropelvic Junction Obstruction: A Logistic Regression Analysis

Li Zhang, Qingtao Zhong, Xuan Wang, Jiali He, Peng Li, Xianhai YU, Shengde Wu, Yi Hua, Feng Liu, Xing Liu, Dawei He, Tao Lin, Guanghui Wei, Deying Zhang

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Ureteral Obstruction; Hydronephrosis; Prognosis; Pediatrics

Online: 17 November 2023 (11:52:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0828.v1

ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer

Irene Fernández De Los Reyes, Marisa Gómez-Dorronsoro, Iñaki Monreal-Santesteban, Agustin F Fernandez, Mario Fraga, Pablo Azcue, Laura Alonso, Beatriz Fernandez-Marlasca, Javier Suárez-Alecha, Alicia Córdoba-Iturriagagoitia, David Guerrero-Setas

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: methylation; prognosis; colon cancer; biomarkers

Online: 12 July 2023 (11:09:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1374.v1

Clinicopathological Features and Prognosis of Resected Pancreatic Ductal Adenocarcinoma Patients with Claudin-18 Overexpression

Se Jun Park, Kabsoo Shin, In-Ho Kim, Tae Ho Hong, MyungAh Lee, Younghoon Kim, Ja Hee Suh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic cancer; claudins; zolbetuximab; prognosis

Online: 19 June 2023 (15:00:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0284.v2

Benchmarking of Machine Learning Models to Assist the Prognosis of Tuberculosis

Maicon Herverton Lino Ferreira da Silva Barros, Geovanne Oliveira Alves, Lubnnia Morais Florêncio Souza, Élisson da Silva Rocha, João Fausto Lorenzato de Oliveira, Theo Lynn, Vanderson Sampaio, Patricia Takako Endo

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: machine learning; benchmarking; tuberculosis; prognosis

Online: 12 April 2021 (12:20:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0242.v1

Characteristics and Prognosis of COVID-19 in Patients with COPD

Desirée Graziani, Joan B Soriano, Carlos Del Rio-Bermudez, Diego Morena, Teresa Díaz, María Castillo, Miguel Alonso, Julio Ancochea, José Luis Izquierdo

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COPD; COVID-19; prevalence; prognosis

Online: 11 September 2020 (05:47:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0109.v1

Should Tumor Infiltrating Lymphocyes, Androgen Receptor, and FOXA1 expression predict Clinical Outcome in Triple Negative Breast Cancer Patients?

Anita Mangia, Concetta Saponaro, Alessandro Vagheggini, Giuseppina Opinto, Matteo Centonze, Chiara Vicenti, Ondina Popescu, Maria Irene Pastena, Francesco Giotta, Nicola Silvestris

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: TILs; TNBC; AR; FOXA1; Prognosis

Online: 8 August 2019 (12:28:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0278.v1

Propranolol Treatment is Associated with Better Survival in Cirrhotic Patients with Hepatic Encephalopathy

Pei-Chang Lee Lee, Yu-Ju Chen, Yueh-Ching Cho, Kuei-Chuan Lee, Ping-Hsien Chen, Wei-Yu Kao, Yi-Hsiang Huang, Teh-Ia Huo, Han-Chieh Lin, Ming-Chih Hou, Fa-Yauh Lee, Jaw-Ching Wu, Chien-Wei Su

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Cirrhosis; Hepatic encephalopathy; Propranolol; Prognosis

Online: 24 December 2018 (12:41:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0197.v1

Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response

Jacqueline Donoghue, Lauren Kerr, Naomi Alexander, Sameer Greenall, Anthony Longano, Nicholas Gottardo, Rong Wang, Viviane Tabar, Timothy Adams, Paul Mischel, Terrance Johns

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: GBM, EGFR, ERBB4, prognosis, therapy

Online: 12 June 2018 (14:51:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1748.v1

Identification and Validation of a PEX5-Dependent Signature for Prognostic Prediction in Glioma

Xuhui Qin, Bing Wang, Xia Lu, Yanyang Song, Wei Wang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Glioma; peroxisome; PEX5; prognosis; immune microenvironment

Online: 26 September 2023 (07:16:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0557.v1

The Role of Biomarkers in the Pathogenesis, Clinical Manifestations, and Therapeutic Approach in Systemic Sclerosis

Anna Bazsó, Emese Kiss

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: systemic sclerosis; organ manifestations; biomarkers; prognosis

Online: 8 August 2023 (02:49:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1126.v1

High Expression of MRE11A, the Gene Involved in the Resection Step During Homologous Recombination, Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients

Daniel de Barcelos Azambuja, Helena de Castro E Glória, Gabriel e Silva Montenegro, Antonio Nocchi Kalil, Jean-Sébastien Hoffmann, Natalia Leguisamo, Jenifer Saffi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: colorectal cancer; homologous recombination; prognosis; Mre11

Online: 16 May 2023 (08:30:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0328.v1

An Update on the General Features of Breast Cancer in Male Patients- a Literature Review

Sinziana Ionescu, Alin Nicolescu, Marian Marincas, Octavia Luciana Madge, Laurentiu Simion

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: male; breast; cancer; diagnosis; treatment; prognosis

Online: 24 May 2022 (09:34:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0314.v2

Clinical Perspectives of Theranostics

Shozo Okamoto, Tohru Shiga, Nagara Tamaki

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: PET; theranostics; radionuclide therapy; cancer; prognosis

Online: 22 February 2021 (07:51:33 CET)

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Working Paper ARTICLE

Distribution of Symptoms, Comorbidities, and Severity Among Patients with COVID-19 by Age Groups, Countries, and Stages of Outbreak: A Systematic Review and Meta-Analysis

Kuan-Fu Chen, Ismaeel Yunusa, Su-Hsun Liu, Chin‐Chieh Wu, Chun‐Fu Yeh, Shih-Tsung Han, Chih-Yang Mao, Dasari Harika, Richard Rothman, Andrew Pekosz

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: COVID-19; sensitivity; specificity; diagnosis; prognosis

Online: 15 January 2021 (12:44:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0346.v1

Heart in Patients Infected with 2019 Novel Coronavirus (COVID-19)

Abdallah Fayssoil, Benjamin Davido, Hazrije Mustafic, Aurélien Dinh, Nicolas Mansencal

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronavirus; heart; prognosis; COVID-19; ICU

Online: 19 April 2020 (13:15:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints201903.0282.v1

Review of Current Evidence in the etiopathogenesis, epidemiology, diagnosis and management of acute pancreatitis

Samantha Varley, Kirsten Rossi, Meghan Murray, Alissa Nichole

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: pancreatitis; epidemiology; diagnosis; complications; treatment; prognosis.

Online: 29 March 2019 (12:13:17 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201809.0203.v1

Primary Female Urethral Cancer：A Case Report and Review of Literature

Yupeng Guan, Gang Yu, Qianyun Tang, Huan Zhou, Zhiming Bai

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Primary urethral cancer; Elderly female; Prognosis

Online: 11 September 2018 (15:43:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1621.v1

DEPDC1 Promotes Thyroid Cancer Migration, Invasion, and Proliferation, and Correlates with Poor Prognosis

Haosheng Tan, Hui Huang, Huaiyu Yang, Jiaxin Qian, Liyuan Wei, Wensheng Liu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: DEPDC1; Dedifferentiation; Expression correlation; Cancer progression; Prognosis

Online: 28 November 2023 (01:42:00 CET)

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Background: We screened key genes involved in the dedifferentiation process of thyroid cancer by analyzing differentially expressed genes in anaplastic thyroid carcinoma (ATC) using Gene Expression Omnibus (GEO) database. Methods: We analyzed differentially expressed genes in ATC from GEO database and constructed a co-expression network using Weighted Gene Co-expression Network Analysis (WGCNA) . Cytoscape was used to calculate top ten key genes based on their gene scores. DEPDC1 was selected as interest gene for further validation, including examination of its prognostic relationship with thyroid cancer, correlation analysis with thyroid differentiation markers, immune cell infiltration, and tumor microenvironment. The impact of DEPDC1 on cancer cell migration, invasion, and proliferation was validated through downregulation and overexpression of DEPDC1 gene in thyroid cancer cell lines c643 and BCPAP. Results: We identified top 10 key genes in ATC: AURKA, TPX2, RACGAP1, MELK, DLGAP5, DEPDC1, KIF2C, NCAPG, CCNB1, and PBK. DEPDC1 showed a strong correlation with the prognosis of thyroid cancer. The odds ratio (OR) for overall survival was 3.5 (P=0.016) in individuals with high DEPDC1 expression, and the OR for disease-free survival was 2.6 (P=0.003). Additionally, the analysis revealed a significant negative correlation between the expression of DEPDC1 and thyroid differentiation markers. Gene Ontology enrichment analysis demonstrated that DEPDC1 co-expressed genes were enriched in cellular processes, cell cycle pathways, and dynamic protein groups. Matrix and immune scoring indicated tumor microenvironment and immune scores were associated with DEPDC1 expression. TIMER2.0 online analysis revealed a strong correlation between DEPDC1 expression and immune cell infiltration in papillary thyroid carcinoma. After downregulation of DEPDC1 expression, the invasion, migration, and proliferation abilities of tumor cells were significantly reduced. Conversely, overexpression of DEPDC1 exhibited the opposite effect. Conclusion: DEPDC1, a newly identified dedifferentiation gene in thyroid cancer, inversely correlated with the degree of differentiation. High expression of DEPDC1 promotes cancer progression and leads to poor prognosis in thyroid cancer.

Preprint ARTICLE | doi:10.20944/preprints202308.2025.v1

Pan-Cancer Profiling of Intron Retention and Its Clinical Significance in Diagnosis and Prognosis

Leihuan Huang, Xin Zeng, Haijing Ma, Yu Yang, Yoshie Akimoto, Gang Wei, Ting Ni

Subject: Biology And Life Sciences, Life Sciences Keywords: intron retention; RNA-seq; cancer; diagnosis; prognosis

Online: 30 August 2023 (14:10:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1572.v1

The Prognostic Nutritional Index (PNI): A New Biomarker for Determining Prognosis in Metastatic Castration-Sensitive Prostate Carcinoma

Halil İbrahim Ellez, Merve Keskinkilic, Huseyin Salih Semiz, Mehmet Emin Arayici, Erdem Kısa, Ilhan Oztop

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: prostate cancer; prognostic nutritional index; inflammation; prognosis

Online: 23 May 2023 (04:50:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0144.v1

Predicting Remission among Perinatal Women with Depression in Rural Pakistan: A Prognostic Model for Task-Shared Interventions in Primary Care Settings

Ahmed Waqas, Siham Sikander, Abid Malik, Najia Atif, Eirini Karyotaki, Atif Rahman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Perinatal depression; prognosis; prognostic modeling; nomogram; Pakistan

Online: 10 May 2022 (15:40:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0042.v1

Magnetic Resonance for Differential Diagnosis of Left Ventricular Hypertrophy: Diagnostic and Prognostic Implications

Giovanni Donato Aquaro, Elisabetta Corsi, Giancarlo Todiere, Chrysanthos Grigoratos, Andrea Barison, Valerio Barra, Gianluca di Bella, Michele Emdin, Fabrizio Ricci, Alessandro Pingitore

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Left ventricular hypertrophy; Echocardiography; Magnetic Resonance; Prognosis

Online: 5 January 2022 (13:10:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202109.0242.v1

The landscape of PDK1 in Breast Cancer

Na Wang, Jianjiang Fu, Zhihua Li, Ningni Jiang, Yanhong Chen, Juan Peng

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: PDK1; breast cancer; survival; prognosis; targeted therapy

Online: 14 September 2021 (14:51:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0420.v1

Hodgkin Lymphoma in People Living With HIV

Jose Tomas Navarro, Jose Moltó, Gustavo Tapia, Josep Maria Ribera

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hodgkin lymphoma, HIV,; antiretroviral therapy; prognosis; etiopathogenesis

Online: 20 August 2021 (14:08:47 CEST)

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Working Paper REVIEW

Hodgkin Lymphoma In People Living With HIV

Jose Tomas Navarro, Jose Moltó, Gustavo Tapia, Josep Maria Ribera

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hodgkin lymphoma, HIV; antiretroviral therapy; prognosis; etiopathogenesis

Online: 2 June 2021 (11:53:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0530.v1

Discovery of Simple Blood-Based Test to Predict Early Onset of Alzheimer’s Using Standard Clinical Mass Spectrometry Platforms

Simona Piccirella, Simone Cristoni, Christopher Fowler, James Doecke, Giulia Abate, Daniela Uberti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; biomarker; prognosis; P53; mass spectrometry

Online: 26 January 2021 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0185.v1

Prognostic Value of the Six-Minute Walk Test in Heart Failure

Vinicius Astolpho, Roberto Barbosa, Gabriela Devens, Leticia Louzada, Pietro Lima, Rodolfo Sylvestre, Renato Serpa, Osmar Calil, Luiz Fernando Barbosa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: heart failure; 6-minute walk test; prognosis

Online: 4 November 2020 (10:08:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0003.v1

Prognostic Impact of Acute Kidney Injury on Decompensated Heart Failure

Layane Batista, Roberto Barbosa, Caroline Carrera, Gabriella Curcio, Pietro Lima, Vinicius Astolpho, Rodolfo Sylvestre, Lucas De Barros, Renato Serpa, Osmar Calil, Luiz Fernando Barbosa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Heart Failure; Acute Kidney Injury; Prognosis; Mortality.

Online: 2 November 2020 (08:09:49 CET)

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Introduction: Decompensated heart failure (HF) is a complex and debilitating syndrome, which constitutes a severe emergency condition with high morbidity and mortality. The kidneys play fundamental roles in the pathophysiology of HF and, in the context of decompensations, acute kidney injury (AKI) has a bilateral cause-and-effect relationship, which can significantly worsen prognosis. However, the interaction between AKI and decompensated HF is poorly understood. Objective: This study aimed to assess the occurrence of AKI in patients hospitalized due to decompensated HF and to analyze its prognostic impact during hospitalization. Methods: Prospective single-center observational study that included patients hospitalized due to decompensated HF in a tertiary-level teaching hospital, conducted between July 2017 and January 2020. Patients who developed AKI during hospitalization were compared with those who did not develop it, until hospital discharge or death. AKI was defined as a serum creatinine increase greater than or equal to 0.3 mg/dl in 48 hours, a 1.5-fold increase in baseline creatinine in seven days or urinary volume <0.5 ml/kg/h during six hours, according to the Acute Kidney Injury Network (AKIN) criteria. The endpoints analyzed were death, need for invasive mechanical ventilation (IMV) and length of hospital stay. The Wilcoxon, Mann-Whitney and unpaired student t tests were used. Results: Ninety-nine patients were included, with a mean age of 65.4 ± 14 years, of which 47 (47.5%) were male and 52 (52.5%) were female. Reduced ejection fraction was observed in 77.8% of patients, whilst 22.2% had a diagnosis of HF with preserved EF. The decompensation clinical classifications were: dry and warm = 7 (7.1%), wet and warm = 72 (72.7%), wet and cold = 15 (15.1%) and dry and cold = 5 (5.1%). The average left ventricular ejection fraction was 38.3% ± 15. AKI ocurred in 22 patients (22.2%). Comparison between patients who evolved with and without AKI showed higher mortality (36.4% vs 10.4%, p = 0.004) and the need for IMV (54.5% vs 13%, p = 0.0001) in the first group. There was no significant difference regarding the length of in-hospital stay (22.9 ± 19 vs 18.8 ± 16 days, p = 0.26). Conclusions: The occurrence of AKI was frequent in patients with decompensated HF requiring hospitalization, affecting approximately one out of five patients. This complication was significantly associated with increased mortality and the need for IMV during hospitalization.

Preprint ARTICLE | doi:10.20944/preprints201903.0064.v1

The Expression of RN7SL494P (7SL) Predicts Nodal Metastasis and Prognosis in Lung Adenocarcinoma

Xiao Zhu, Yongmei Huang, Hui Luo, Ying Xu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TCGA; lung adenocarcinoma; RN7SL494P; nodal metastasis; prognosis

Online: 5 March 2019 (12:27:55 CET)

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The metastasis of lung cancer can spread to the lymph nodes around the lungs. Metastasis, rather than the primary cancer, judges patients survival. Wherefore, a more detailed study on transcriptome of metastatic lung adenocarcinoma including primary carcinoma was carried out. LUAD RNA-seq data and the corresponding clinical information were available from The Cancer Genome Atlas (TCGA), which included 522 cases but only 515 cases have transcriptome data. Differential expression analyses between cases and controls, between primary cancer and metastasis subgroup, or between TNM stages, were respectively carried out using edgeR package. Then, the Kruskal-Wallis tests were used to verify the gradient changes of cancer metastasis or staging with the differential expression genes. The survival analyses were calculated using the Kaplan-Meier algorithm and log-rank test. The functional predictions for the differentially expressed genes were porformed with the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (GO/KEGG). Single gene set enrichment analysis (single GSEA) was run to explore the biological pathways associated with the expressions of RN7SL494P gene based on the Molecular Signatures Database (MSigDB). 406 and 439 differentially expressed genes were identified respectively in lymph node metastasis or TNM stages. 112/296 intersection genes were associated with nodal metastasis and/or staging, among them only 25 genes were associated with the nodal metastasis, 13 genes were associated with the staging with gradient changes. Only one gene (RN7SL494P) was found to be associated with prognosis. But RN7SL494P was not found joining any biological functions or processes or cellular components with GO/KEGG analyses. Finally, single GSEA enrichment and pathway analyses showed that RN7SL494P might be involving in cancer development process and poor outcome in lung adenocarcinoma. These findings highlight the potential applications of RN7SL494P as a promising molecular predictor not only in nodal metastasis but prognosis evalution in lung adenocarcinoma patients.

Preprint ARTICLE | doi:10.20944/preprints201901.0155.v1

Prognostic Significance of EIF4G1 in Patients with Pancreatic Ductal Adenocarcinoma

Tae Sik Goh, Mihyang Ha, Jung Sub Lee, Dae Cheon Jeong, Eun Sang Jung, Myoung-Eun Han, Yun Hak Kim, Sae-Ock Oh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: EIF4GI; pancreatic ductal adenocarcinoma; prognosis; GEO; TCGA

Online: 16 January 2019 (07:54:33 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0077.v1

Impact of Sarcopenia as a Prognostic Biomarker of Bladder Cancer

Hiroshi Fukushima, Kosuke Takemura, Hiroaki Suzuki, Fumitaka Koga

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: sarcopenia; prognosis; biomarker; bladder cancer; urothelial carcinoma

Online: 3 August 2018 (16:05:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0190.v1

Epithelial-Mesenchymal Transition in Tumor Cells and Activated Intra-Tumor Immunity Respectively Are Correlated With Prognosis and Chemo-Sensitivity in Breast Cancer Patients With a Non-pathological Response to Neoadjuvant Chemotherapy

Junichi Kurebayashi, Takayuki Iwamoto, Yoshikazu Koike, Tomoka Mikami, Fumiaki Sanuki, Takuya Moriya, Yutaka Yamamoto, Naruto Taira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: breast cancer; neoadjuvant chemotherapy; vimentin; vascular invasion; prognosis

Online: 4 October 2023 (11:22:07 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202310.0091.v1

Neutrophil to Lymphocyte Ratio as a Prognostic Marker in Amyotrophic Lateral Sclerosis

Camille Cotet, Hugo Alarcan, Olivier Herault, Philippe Corcia, Patrick Vourc'h, Christian R Andres, Hélène Blasco, Charlotte Veyrat-Durebex

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Amyotrophic lateral sclerosis; neutrophils; lymphocytes; NLR; survival; prognosis

Online: 3 October 2023 (05:55:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0880.v1

Imaging Carotid Plaque Inflammation Using Positron Emission Tomography: Emerging Role in Clinical Stroke Care, Research Applications, and Future Directions

John McCabe, Nicholas Evans, Sarah Gorey, Shiv Bhakta, James Rudd, Peter Kelly

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: inflammation; stroke; prognosis; positron emission tomography; recurrence; carotid

Online: 13 July 2023 (10:11:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2054.v1

Inhibition of CDK1 by RO-3306 Exhibits Anti-Tumorigenic Effects in Ovarian Cancer Cells and a Transgenic Mouse Model of Ovarian Cancer

Yu Huang, Yali Fan, Ziyi Zhao, Xin Zhang, Katherine Tucker, Allison Staley, Hongyan Suo, Wenchuan Sun, Xiaochang Shen, Boer Deng, Stuart R Pierce, Lindsay West, Yajie Yin, Michael J Emanuele, Chunxiao Zhou, Victoria Bae-Jump

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: CDK1; RO-3306; ovarian cancer; apoptosis; invasion; prognosis

Online: 28 June 2023 (16:02:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2013.v1

The Role of miRNAs in the Progression and Prognosis of Gliomas

Omar Bassam Tluli, Mazyona Jumah Al-Maadhadi, Aisha Abdulla Al-Khulaifi, Aishat Funmilayo Akomolafe, Shaikha Yousef Al-Kuwari, Roudha Saed Al-Khayarin, Cristina Maccalli, Shona Pedersen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: microRNA; glioma; cancer stem cells.; prognosis; targeted therapy

Online: 28 June 2023 (11:06:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0567.v1

Stable Coronary Artery Disease: Who Finally Benefits from Coronary Revascularization in the Modern Era? The ISCHEMIA and Interim ISCHEMIA-EXTEND Analysis

Leonid L Bershtein, Alexey Sumin, Elizaveta Zbyshevskaya, Victoria Gumerova, Darejan Tsurtsumia, Igor Kochanov, Alina Andreeva, Vartan Piltakian, Sergey Sayganov

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic coronary syndromes; revascularization; prognosis; ISCHEMIA; ISCHEMIA-EXTEND

Online: 8 June 2023 (02:13:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0175.v1

Prognostic Impact of Non-cardiac Comorbidities on Long-Term Prognosis in Patients with Reduced and Preserved Ejection Fraction Following Acute Myocardial Infarction

Lidija Savić, Igor Mrdovic, Milika Asanin, Sanja Stankovic, Ratko Lasica, Matić Dragan, Damjan Simic, Gordana Krljanac

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: non-cardiac comorbidities; ejection fraction; myocardial infarction; prognosis

Online: 2 June 2023 (10:00:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0342.v1

A Novel Anoikis-Related Gene Signature Predicts Prognosis in Patients with Low-Grade Glioma and Reveals Immune Infiltration

Songyun Zhao, Hao Chi, Wei Ji, Qisheng He, Guichuan Lai, Gaoge Peng, Xiaoyu Zhao, Chao Cheng, Weiyi Huang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: anoikis; Low-grade glioma; signature; prognosis; immune microenvironment

Online: 22 September 2022 (10:38:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0104.v1

HLA-G 14bp ins/del Polymorphism, Plasma Level of Soluble HLA-G and Association with IL-6/IL-10 Ratio and Survival of Glioma Patients

Maria Bucova, Kristina Kluckova, Jan Kozak, Boris Rychly, Marian Svajdler, Viktor Matejcik, Juraj Steno, Eszter Zsemlye, Vladimíra Ďurmanová

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: glioma; HLA-G; IL-6; polymorphism; prognosis; survival

Online: 7 December 2021 (12:55:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0063.v1

Challenging the Current Paradigm of Liquid Biopsy Through Dielectrophoresis (DEP) In Prostate Cancer

Giorgio I. Russo, Nicolò Musso, Alessandra Romano, Giuseppe Caruso, Salvatore Petralia, Luca Lanzanò, Giuseppe Broggi, Massimo Camarda

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: circulating tumor cells; dielectrophoresis; prostate cancer; detection; prognosis

Online: 6 December 2021 (12:03:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0455.v1

Major Prosthetic Factors Influencing the Prognosis of Implant Prosthodontics. A Systematic Review.

Javier Montero

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Prognosis; prosthodontics; dental implant; clinical performance; risk factor.

Online: 18 December 2020 (11:34:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0602.v1

Unusual Faces of Bladder Cancer

Claudia Manini, José I. López

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Bladder cancer; diagnosis; differential diagnosis; prognosis; histopathology; immunohistochemistry

Online: 29 October 2020 (09:25:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0718.v1

Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children

D M Kamrul Hasan, Shafayat Hossain Evan, Md Rezaul Karim, Xin Yi Men, Zhang Huifeng, Chen Yuan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Sepsis, Septic shock, Lactic acid, Dynamic monitoring, Prognosis

Online: 30 July 2020 (11:23:48 CEST)

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Objectives: To investigate the value of early lactate dynamic monitoring index in predicting prognosis of patients with sepsis and septic shock. Methods: We performed our test on 50 patients. Out of 50 patients, 28 are male, and 22 are female. Prospectively studied pediatric patients with septic shock were performed. Vital signs, Lactate clearance, were obtained at presentation 6 h, 12 h, 24 h over the first 48 h of hospitalization. The therapy received, outcome parameters of mortality and duration of hospitalization were recorded. Results: The statistical data and comparative analysis showed that an average of 16.88 days after admission, 5 patients have died, 17 patients are poorly prognosis leaves the hospital, and the remaining 28 are recovered and discharged. The primary outcome variable of mean 16 days hospitalization mortality rate was 10%. Poor prognosis 34% and fully recovery 56 % were observed. In this retrospective cohort study, a lactate level of more than 2.5mmol/L was the best threshold to predict 28-day mortality among severe sepsis and septic shock patients. In our research, we found mean LC 6 h 3.08mmol/L, and after 48 h mean it is 1.79mmol/L. Significant LC 6 h found, which is 8.08mmol/L in the death group patient where 48 h mmol/L shows significant high. Poor prognosis also presents a clinical increase of lactate level high in the LC 6 h analysis, which is 3.32mmol/L. Recovered patients showed a significant improvement after administering treatment depending on the patient organ involvement and good decrease of lactate reports achieved, which is 1.20mmol/L, where admission reports show it was 1.91mmol/L in LC 6 h. Mean Heart rate 94/51mmhg, pulse 119, temperature 39℃, respiratory rate 32.26, and urine output 456 ml recorded during our study. Death patient shows a remarkable detonation of those reports but has a significant clinical report with the recovered patients. Conclusion: The early lactate dynamic monitoring index has a high value in predicting sepsis and septic shock patients' prognosis, thus worth popularizing.

Working Paper ARTICLE

Identification of Nine lncRNAs Signature for Predicting Survival Benefit of Melanoma Patients Treated with Immune Checkpoint Inhibitors

Jian-Guo Zhou, Bo Liang, Jian-Guo Liu, Su-Han Jin, Si-si He, Benjamin Frey, Ning Gu, Rainer Fietkau, Markus Hecht, Hu Ma, Udo Gaipl

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lncRNA; melanoma; prognosis; immune checkpoint inhibit; WGCNA; NMF

Online: 11 July 2020 (04:35:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0221.v1

Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985–2014

Amro K. Bin Abdulrahman, Yousef R. Bukhari, Abdulaziz M. Faqihi, Khalid A. Bin Abdulrahman, Juan Gabriel Ruiz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: brain cancer; glioblastoma multiforme; giant cell glioblastoma; prognosis

Online: 17 May 2019 (08:40:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1440.v1

Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases

Sofía Tesolato, Juan Vicente-Valor, Jose-Ramón Jarabo, Joaquín Calatayud, Melchor Saiz-Pardo, Asunción Nieto, Dolores Álvaro-Álvarez, María-Jesús Linares, Carlos-Alfredo Fraile, Florentino Hernando, Pilar Iniesta, Ana-María Gómez-Martínez

Subject: Biology And Life Sciences, Life Sciences Keywords: Interstitial lung diseases; Idiopathic pulmonary fibrosis; Telomere length; Prognosis

Online: 23 November 2023 (17:35:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0897.v1

Role of rs873601 Polymorphisms in Prognosis of Lung Cancer Patients Treated with Platinum-Based Chemotherapy

Ting Zou, Jun Yan Liu, Qun Qin, Jie Guo, Wen Zhi Zhou, Xiang Ping Li, Honghao Zhou, Juan Chen, Zhao Qian Liu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: lung cancer; platinum-based chemotherapy; ERCC5; Genetic polymorphism; prognosis

Online: 13 October 2023 (11:34:21 CEST)

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Background: Lung cancer is still the most lethal malignancy in the world from the report of Cancer Statistics in 2021. Platinum-based chemotherapy combined immunotherapy is the first-line treatment in lung cancer patients. However, the 5-year survival rate always affected by the adverse reaction and drug resistance caused by platinum-based chemotherapy. DNA damage and repair system is one of the important mechanisms which can affect the response to chemotherapy and clinical outcome in lung cancer patients. Objective: The objective of this study is to find the relationship between the polymorphisms of DNA repair genes with the prognosis in platinum-based chemotherapy in lung cancer patients. Patients and Methods: We performed genotyping in 17 single nucleotide polymorphisms (SNPs) of Excision Repair Cross-Complementation group (ERCC) genes and X-ray Repair Cross-Complementing (XRCC) genes of 345 lung cancer patients by Sequenom MassARRAY. We used Cox proportional hazard models, state and plink to analyze the associations between SNPs and the prognosis of lung cancer patients. Results: We found that the ERCC5 rs873601 was associated with the overall survival time in lung cancer patients treat by platinum-based chemotherapy (p=0.031*). We also discovered that the polymorphisms in rs873601 was significantly associated with the prognosis in age more than 55 years, Small Cell Lung Cancer (SCLC) and smoking patients, Long Intergenic Non-protein Coding RNA (PNKY) rs2444933 in age less than 55 years, SCLC, metastasis and stage III/IV/ED patients, Short Tau Inversion Recovery (STIR1) rs3740051 in SCLC and metastasis patients, PNKY rs1869641 in SCLC patients, XRCC5 rs1051685 in non-metastasis patients, respectively. Conclusion: The ERCC5 rs873601(G>A) maybe a valuable biomarker for predicting the prognosis in lung cancer patients treated with platinum-based chemotherapy. Statements and Declarations: The authors declare that they have no conflict of interest.

Preprint ARTICLE | doi:10.20944/preprints202309.1409.v1

Early and Late Complications after Cataract Surgery in Patients with Uveitis

Gentian Bajraktari, Tomislav Jukić, Miro Kalauz, Martin Oroz, Andrea Radolović Bertetić, Nenad Vukojević

Subject: Medicine And Pharmacology, Ophthalmology Keywords: uveitis-associated cataract; postoperative complications; phacoemulsification; uveitis; visual prognosis

Online: 21 September 2023 (04:56:43 CEST)

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Background and Objectives: Uveitis, a prevalent eye disorder characterized by inflammatory processes, often leads to cataract formation and significant visual impairment. This study aimed to evaluate preoperative conditions and postoperative outcomes following cataract surgery in uveitis patients. Materials and Methods: A retrospective study was conducted at the University Hospital Center Rebro Zagreb, Croatia, involving uveitis patients who underwent cataract surgery between 2013 and 2022. Eligible patients had uveitic cataracts affecting visual acuity or posterior segment visualization in a "quiet eye" and were disease-inactive for at least three months. Patients with certain preexisting ocular conditions were excluded. Data collected included patient demographics, uveitis type, preoperative therapy, preexisting lesions, and postoperative outcomes such as visual acuity, intraocular pressure, central macular thickness, and complications. Statistical analysis was performed to identify risk factors associated with complications. Results: The study included 105 patients. After cataract surgery, there was a significant improvement in visual acuity at various time points, with 90% of eyes showing improvement. Intraocular pressure decreased over time. Central macular thickness increased at three months post-surgery but remained stable thereafter. Early and late complications were observed in 52.4% and 63.8% of eyes, respectively. The most common complications were posterior capsular opacification, macular edema, and epiretinal membrane. Factors associated with complications varied between early and late stages but included age, age at onset of uveitis, and uveitis type. Conclusion: Cataract surgery in uveitis patients presents challenges but can lead to significant visual improvement. This study highlights the importance of careful patient selection, preoperative and postoperative inflammation management, and precise surgical techniques. Although complications were common, they were manageable, and most patients experienced improved vision, emphasizing the benefits of cataract surgery in this population. However, future investigations should address the study's limitations and further refine perioperative strategies.

Preprint REVIEW | doi:10.20944/preprints202308.1837.v1

Colorectal Cancer: From Risk Factors to Oncogenesis

Vlad Alexandru Ionescu, Gina Gheorghe, Nicolae Bacalbasa, Alexandru Laurentiu Chiotoroiu, Camelia Diaconu

Subject: Biology And Life Sciences, Life Sciences Keywords: colorectal cancer; risk factors; oncogenesis; lifestyle; gut microbiota; prognosis

Online: 28 August 2023 (08:44:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1287.v1

Applying Stochastic Models to Analyze Vibration Features of Roller Bearings

Saima Bhatti, ASIF Ali Shaikh, Asif Mansoor, Murtaza Hussain

Subject: Engineering, Mechanical Engineering Keywords: machinery; prognosis framework; vibration data; roller bearings; stochastic models

Online: 18 August 2023 (09:04:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2009.v1

Sex Differences in Prognosis of Heart Failure Due to Ischemic and Nonischemic Cardiomyopathy

Antonio Padua Mansur, Antonio Carlos Pereira-Barretto, Carlo Henrique Del Carlo, Solange Desirée Avakian, Naomi Kondo Nakagawa, Luiz Antonio Machado Cesar, Edimar Alcides Bocchi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; cardiomyopathy; ischemic heart disease; prognosis; women; men

Online: 29 June 2023 (07:27:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0849.v1

Epigenetic Alterations That Are the Backbone of Immune Evasion in T-Cell Malignancies

Mihaela Andreescu

Subject: Medicine And Pharmacology, Hematology Keywords: Molecular biology; infectious diseases; clinical diagnostic; early detection; prognosis

Online: 12 June 2023 (14:31:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0335.v1

Prognostic Factors in Epithelioid Hemangioendothelioma: Analysis of a Nationwide Molecularly/Immunohistochemically Confirmed Cohort of 57 Cases

Tess Tomassen, Yvonne M H Versleijen-jonkers, Melissa H S Hillebrandt-roeffen, Patricia H J Van Cleef, Thijs Van Dalen, Marije E Weidema, Ingrid M E Desar, Uta Flucke, Joost M Van Gorp

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Epithelioid hemangioendothelioma; Aggressive; Malignant; Prognosis; Risk stratification; Lymph node

Online: 5 June 2023 (14:26:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1725.v1

Molecular Insights into the Role of Gut Microbiota in Antibiotic Therapy Selection and Resistance Mitigation

Mihaela Andreescu

Subject: Medicine And Pharmacology, Hematology Keywords: Molecular biology; infectious diseases; clinical diagnostic; early detection; prognosis

Online: 25 May 2023 (03:34:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0047.v1

Prognostic Impact of Visceral Fat Area Measured by Bioelectrical Impedance Analysis on Oncologic Outcomes of Colorectal Cancer

Kyeong Eui Kim, Sung Uk Bae, Woon Kyung Jeung, Seung Kyu Baek

Subject: Biology And Life Sciences, Food Science And Technology Keywords: colorectal neoplasm; nutrition assessment; body composition; electric impedance; prognosis

Online: 5 September 2022 (07:33:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0235.v1

Coarsened Exact Matching of Excisional to Plasma-Ablative Ab Interno Trabeculectomy

Mohamad Dakroub, Raoul Verma-Fuehring, Alicja Strzalkowska, Jost Hillenkamp, Yousef Al Yousef, Nils A. Loewen

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; TrabEx; Trabectome; ab-interno trabeculectomy; prognosis; intraocular pressure

Online: 14 September 2021 (11:01:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0527.v1

Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries

In Woong Han, Jangho Park, Eun Young Park, So Jeong Yoon, Gang Jin, Dae Wook Hwang, Kuirong Jiang, Wooil Kwon, Xuefeng Xu, Jin Seok Heo, Delinag Fu, Woo-Jung Lee, Xueli Bai, Yoo-Seok Yoon, Yinmo Yang, Keun Soo Ahn, Chunhui Yuan, Hyeon Kook Lee, Bei Sun, Eun Kyu Park, Seung Eun Lee, Sunghwa Kang, Wen hui Lou, Sang-Jae Park

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Nonfunctioning neuroendocrine tumor of pancreas; Prognosis; Resection; Risk factors

Online: 23 July 2021 (08:07:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0434.v1

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Hye-Young Kim, Ha Young Jo, Seong Heon Kim

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

Online: 20 July 2021 (09:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0074.v1

Impact of Physical Activity on Recurrence Dynamics in Early Breast Cancer Patients

Elia Biganzoli, Christine Desmedt, Romano Demicheli

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: early breast cancer; prognosis; physical activity; tumor dormancy; recurrence

Online: 2 February 2021 (08:24:31 CET)

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Several studies have suggested that pre and/or postdiagnosis physical activity can reduce the risk of recurrence in breast cancer patients, however its effect according to follow-up time has not yet been investigated. We analyzed recurrence and mortality dynamics in randomized clinical trials (RCTs) from Australia and Canada. The combined Australian RCTs evaluated, at median follow-up of 8.3 years, an 8-month pragmatic exercise intervention in 337 women with newly diagnosed breast cancer, while the Canadian RCT evaluated, at median follow-up of 7.4 years, supervised aerobic or resistance exercise during chemotherapy in 242 patients. For each RCT, the control arm consisted of patients undergoing usual care. We estimated the event dynamics by the discrete hazard function, through flexible regression of yearly conditional event probabilities with generalized additive models. In the considered RCTs, the recurrence and mortality risk of patients enrolled in the physical activity arm was stably reduced at medium/long term after five year of follow-up. In the Australian RCTs where patients were recruited by urban versus rural area, the latter group did not display benefit from physical activity. Estimated Odds Ratios (95% Confidence Intervals) for Disease Free Survival (DFS) in urban women were 0.63 (0.22-1.85); 0.27 (0.079-0.90); 0.11 (0.013-0.96) at the 3rd, 5th and 7th year of follow-up, respectively. For rural women, DFS patterns were overlapping with ORs approximating 1 at the different years of follow-up. Although not reaching statistical evidence, the estimates in the Canadian trial were in line with the results from the Australian urban women with ORs (95% CI) forDFS of 0.70 (0.33-1.50); 0.47 (0.19-1.18); 0.32 (0.077-1.29) at 3rd, 5th, 7th follow-up year, respectively. While we acknowledge that the analyzed RCTs were not designed for investigating disease recurrence over time, these results support the evidence that physical activity reduces the risk of developing medium/long-term metastases. Additional translational research is needed to clarify the mechanisms underlying these observations.

Preprint ARTICLE | doi:10.20944/preprints202012.0476.v1

Exhaustive Capture of Ovarian Cancer Transcriptional and Genomic Variant Integrating Canonical and Mapping-Free Protocols

Zhiqin Fu, Chao Lu, Chao Ding, Chengxi Zhou, Tingting Yu, Yue Yang, Liang Shi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Ovarian cancer; mapping-based; mapping-free; SNVs; survival prognosis

Online: 18 December 2020 (15:15:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0441.v1

Pulmonary Vesicle and Bullae Formation in Patients With COVID-19: Experiences from Wuhan

Hexiao Tang, Li Zhang, Yanhong Wei, Changsheng Li, Bo Hu, Jinping Zhao, Nahush A Mokadam, Hua Zhu, Jun Lin, Sufang Tian, Xuefeng Zhou

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Corona Virus Disease 2019; pulmonary vesicle; prognosis; surgical treatment

Online: 24 April 2020 (12:06:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0109.v1

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

Trond Aasen, Irene Sansano, Maria Ángeles Montero, Cleofé Romagosa, Jordi Temprana-Salvador, Alexandre Martínez-Marti, Teresa Moliné, Javier Hernández-Losa, Santiago Ramón y Cajal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: connexins; Cx43; gap junctions; lung cancer; immunohistochemistry; prognosis; nuclear

Online: 13 February 2019 (10:30:49 CET)

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Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. This feature is connexin- and tissue-specific and may be mediated by complex signalling pathways through gap junctions or hemichannels or by completely junction-independent events. Lung cancer is the number one cancer in terms of mortality worldwide, and novel biomarkers and therapeutic targets are urgently needed. Our objective was to gain a better understanding of connexins in this setting. We used several in silico tools to analyse TCGA data in order to compare connexin mRNA expression between healthy lung tissue and lung tumours and correlated these results with gene methylation patterns. Using Kaplan-Meier plotter tools, we analysed a microarray dataset and an RNA-seq dataset of non-small cell lung tumours in order to correlate connexin expression with patient prognosis. We found that connexin mRNA expression is frequently either upregulated or downregulated in lung tumours. This correlated with both good and poor prognosis (overall survival) in a clear connexin isoform-dependent manner. These associations were strongly influenced by the histological subtype (adenocarcinoma versus squamous cell carcinoma). We present an overview of all connexins but particularly focus on four isoforms implicated in lung cancer: Cx26, Cx30.3, Cx32 and Cx43. We further analysed the protein expression and localization of Cx43 in a series of 72 human lung tumours. We identified a subset of tumours that exhibited a unique strong nuclear Cx43 expression pattern that predicted worse overall survival (p=0.014). Upon sub-stratification, the prognostic value remained highly significant in the adenocarcinoma subtype (p=0.002) but not in the squamous carcinoma subtype (p=0.578). This finding highlights the importance of analysis of connexin expression at the protein level, particularly the subcellular localization. Elucidation of the underlying pathways regulating Cx43 localization may provide for novel therapeutic opportunities.

Preprint REVIEW | doi:10.20944/preprints201808.0454.v1

Biomarkers for Predicting Clinical Outcomes of Chemoradiation-Based Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer

Fumitaka Koga, Kosuke Takemura, Hiroshi Fukushima

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: biomarker; chemoradiation; prognosis; bladder preservation; bladder neoplasm; urothelial carcinoma

Online: 27 August 2018 (11:13:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0152.v1

Targeting Cytochrome P450 Enzymes in Ovarian Cancers: new approaches for Tumour-Selective Interventions

Yousef M. Al-saraireh, Fatemah O. F. O. Alshammari, Omar H. Abu-azzam, Sa’ed M. Al-dalain, Yahya M. Al-sarayra, Mansour Haddad, Hafiz Makeen, Aiman Al-Qtaitat, Mohammad Almermesh, Sameeh A. Al-sarayreh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cytochromes P450; ovarian cancer; gynecologic cancers; pro-drug; xenobiotics; prognosis

Online: 4 September 2023 (11:58:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0879.v1

Enhanced risk stratification in early-stage endometrial cancer: Integrating Molucular-L1CAM Classification and Simplified L1CAM/p53 Categorization

Seungyeon Joe, Miseon Lee, Jun Kang, Joori Kim, Sook-Hee Hong, Sung Jong Lee, Keun Ho Lee, Ahwon Lee

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: early-stage endometrial cancer; molecular classification; L1CAM; risk stratification; prognosis

Online: 11 August 2023 (08:38:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0385.v1

Impact of BRAFV600E Mutation on Event Free Survival in Patients with Papillary Thyroid Carcinoma: A Retrospective Study in a Romanian Population

Adela Nechifor-Boila, Ancuta Cota, Claudia Banescu, Valeriu Moldovan, Doina Piciu, Septimiu Voidazan, Angela Borda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: papillary thyroid cancer; BRAFV600E mutation; lymph node metastasis; prognosis; outcomes.

Online: 6 July 2023 (07:14:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1767.v1

Usefulness of Tumor Marker Score for Prediction of Prognosis in Hepatocellular Carcinoma Patients Treated with Atezolizumab plus Bevacizumab: A Multicenter Retrospective Study

Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; tumor marker; atezolizumab plus bevacizumab; prognosis; predictive model

Online: 26 June 2023 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0782.v1

Long-term Outcomes of Birdshot Chorioretinopathy Treated With Corticosteroids: A Retrospective Cohort Study

Dino Ferracci, Thibaud Mathis, Antoin Gavoille, Mathieu Gerfaud-Valentin, Arthur Bert, Meriem Hafidi, Philippe Denis, Olivier Loria, Laurent Kodjikian, Pascal Sève

Subject: Medicine And Pharmacology, Ophthalmology Keywords: birdshot chorioretinopathy (BSCR); corticosteroids; inflammatory macular edema; prognosis; relapse; uveitis.

Online: 12 June 2023 (07:17:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0837.v1

Prognostic Performance of Three Lymph Node Staging Systems on Gastric Signet Ring Cell Carcinoma

Limin Zhang, Qi You, Bao Liu

Subject: Biology And Life Sciences, Biophysics Keywords: Gastric signet ring cell carcinoma; lymph node metastases; LODDS; prognosis

Online: 24 April 2023 (09:00:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0015.v1

Serum Biomarkers of Inflammation in the Identification and Prognostication of Frail Patients Undergoing Emergency Laparotomy

Michael George, Rajarshi Mukherjee

Subject: Medicine And Pharmacology, Surgery Keywords: Frailty; elderly; inflammageing; inflammation; biomarkers; prognosis; outcomes; emergency; laparotomy; surgery

Online: 3 April 2023 (08:20:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0391.v1

Feature Selection in the Context of Prognostic Health Management

Indrawata Wardhana

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: prognosis and health management, preprocessing data, feature extraction, feature selection.

Online: 22 March 2023 (04:31:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0400.v1

Estimation of ALU Repetitive Element in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer

Madhumathy G Nair, Rakesh S Ramesh, Chandrakala M, Apoorva D, Snijesh VP, Vishakha Ramamurthy, Vidya M Somashekaraiah, Anupama CE, Kiruthiga Raghunathan, Anuradha Panigrahi, Manjula Das, Sujan K. Dhar, Jyothi S Prabhu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast Cancer; Liquid biopsy; ctDNA; ALU 247; Disease progression; Prognosis

Online: 21 December 2022 (11:43:52 CET)

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Background: Liquid biopsy is widely recognised as an efficient diagnostic method in oncology for disease detection and monitoring. Though examination of circulating tumor cell (CTC) is mostly implemented for assessment of genomic aberrations, need of complex methodologies for their detection has impeded its acceptance in low resource settings. We evaluated the cell free DNA (cfDNA) as a liquid biopsy tool and investigated its utility in breast cancer patients. Methods: Total cell free DNA was extracted from plasma of breast cancer patients (n=167) with median follow up of more than 5 years, at various stages of the disease. Quantitative PCR was performed to estimate the copy numbers of two fractions of ALU repetitive elements (ALU 115 and ALU 247) and DNA Integrity (DI) was calculated as the ratio of ALU 247/115. Mutations in TP53 and PIK3CA in the cfDNA was estimated by next-gen sequencing (NGS) in a subset of samples. Association of the levels of both the ALU fragments with various clinico-pathological factors and disease-free survival at various stages were examined. Nomogram models were constructed with clinical variables and ALU 247 levels to predict disease-free survival and best performing model was evaluated by decision curve analysis. Results: DI and ALU 247 levels were significantly lower (p<0.0001) in the post-operative plasma when compared to their pre-surgery levels. DI and ALU 247 were found to be significantly higher in patients with metastasis (p<0.05). Patients with higher levels of ALU 247 in their post-operative plasma had significantly poor disease-free survival (p=0.005). Higher level of ALU 247 in circulation also correlated with low tumor-infiltrating lymphocytes (TIL) within their primary tumors in the ER-negative breast cancer subtype (p=0.01). Cox proportional hazard analysis confirmed ALU 247 as an independent variable of disease-free survival both in univariate and multivariate analysis [HR 1.3 (95% CI 1.047 to 1.613, p= 0.017)]. Nomogram model showed addition of ALU 247 with other variables significantly improved (C-index-0.823) the predictive ability of the model. Conclusion: Our results confirm the utility of cfDNA as an evolving liquid biopsy tool for molecular analysis. Evaluation of larger fragment of cfDNA estimated through ALU 247 can provide vital information concurrent with the pathological process of disease evolution in breast cancer and warrants expansion to other cancer types.

Preprint ARTICLE | doi:10.20944/preprints202212.0068.v1

Is there a Role of Warburg Effect in Prostate Cancer Aggressiveness? Analysis of Expression of Enzymes of Lipidic Metabolism by Immunohistochemistry in Prostate Cancer Patients (DIAMOND Study)

Giorgio Ivan Russo, Maria Giovanna Asmundo, Arturo Lo Giudice, Giuseppe Trefiletti, Sebastiano Cimino, Matteo Ferro, Riccardo Lombardo, Cosimo De Nunzio, Giuseppe Morgia, Eliana Piombino, Maria Failla, Rosario Caltabiano, Giuseppe Broggi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: prostate cancer; Warburg effect; prognosis; radical prostatectomy; lipidic; metabolism; mortality

Online: 5 December 2022 (08:50:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0289.v1

Prognostic Value of Resistance Proteins in Plasma Cells From Multiple Myeloma Patients Treated With Bortezomib

Pawel Robak, J.; Szemraj, D.; Mikulski, I.; Drozdz, K; Juszczak, D. Jarych, W.; Robak, K; Kościelny, W.; Fendler, T.; Robak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bortezomib; cMAF; MAFb; multiple myeloma; POMP; prognosis; PFS; survival; OS

Online: 13 August 2021 (08:43:42 CEST)

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Working Paper ARTICLE

Prognostic Impact of Immunoglobulin Kappa C (IGKC) In Early Breast Cancer

Marcus Schmidt, Karolina Edlund, Jan G Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Slavomir Krajnak, Marco J. Battista, Walburgis Brenner, Annette Hasenburg, Jörg Rahnenführer, Mathias Gehrmann, Pirkko-Liisa Kellokumpu-Lehtinen, Ralph M Wirtz, Heikki Joensuu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: triple-negative breast cancer; prognosis; immune system; immunoglobulin kappa C

Online: 31 May 2021 (12:27:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0569.v1

Quantitative Imaging and Radiomics in Multiple Myeloma: opportunity or hype?

Alberto Stefano Tagliafico, Alida Dominietto, Liliana Belgioia, Cristina Campi, Daniela Schenone, Michele Piana

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: multiple myeloma; computed tomography; artificial intelligence; radiomics; prognosis; imaging; diagnosis

Online: 23 November 2020 (09:17:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0466.v1

Relationship between Dietary Fiber Intake and the Prognosis of Amyotrophic Lateral Sclerosis

Haelim Yu, Seung Hyun Kim, Min-Young Noh, Sang-Gon Lee, Yongsoon Park

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Amyotrophic lateral sclerosis; dietary fiber; gut microbiota; prognosis; vegetable fiber

Online: 22 October 2020 (21:26:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0159.v1

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Hossein Tabatabaeian, Samantha Yang Peiling, Yvonne Tay

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Thyroid carcinoma; non-coding RNA; radioactive iodine; drug resistance; prognosis

Online: 7 October 2020 (14:28:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0280.v1

Altered Spatial Composition of the Immune Cell Repertoire in the Bone Marrow Stem Cell Niche in Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia

Marcus Bauer, Christoforos Vaxevanis, Haifa Kathrin Al-Ali, Nadja Jaekel, Christin Le Hoa Naumann, Judith Schaffrath, Achim Rau, Barbara Seliger, Claudia Wickenhauser

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: MDS; immune cell repertoire; prognosis; multiplex immunohistochemistry; stem cell niche

Online: 13 September 2020 (11:51:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0235.v1

Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis

Li Zhang, Jia Liu, Peisong Wang, Shuai Xue, Jie Li, Guang Chen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: strap muscle invasion; prognosis; differentiated thyroid carcinoma; meta-analysis; review

Online: 14 May 2020 (11:35:41 CEST)

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Gross strap muscle invasion (gSMI) in patients with differentiated thyroid cancer (DTC) was defined as high-risk recurrent group in the 2015 American Thyroid Association guidelines. However, controversy persists because several studies suggested gSMI had little effect on disease outcome. Herein, a systematic review and meta-analysis was conducted to investigate impact of gSMI on outcome of DTC. Methods: A systematic search of electronic databases (PubMed, EMBASE, Cochrane Library, and MEDLINE) for studies published until February 2020 was performed. Case-control studies and randomized controlled trials that studied the impact of gSMI on outcome of DTC were included. Results: Six studies (all retrospective studies) involving 13639 patients met final inclusion criteria. Compared with no extrathyroidal extension (ETE), patients with gSMI were associated with increased risk of recurrence (P=0.0004,OR, 1.46; 95% CI: 1.18 to 1.80) and lymph node metastasis (LNM) (P<0.00001,OR 4.19;95% CI. 2.53 to 6.96). For mortality (P=0.34,OR 1.47;95% CI:0.67 to 3.25), ten-year disease-specific survival (P=0.80, OR 0.91;95% CI:0.44 to 1.88) and distant metastasis (DM) (P=0.21, OR 2.94;95% CI. 0.54 to 15.93), there was no significant difference between gSMI and no ETE group. In contrast with maximal ETE, patients with gSMI were associated with decreased risk of recurrence (P<0.0001,OR, 0.58; 95% CI: 0.44 to 0.76) , mortality (P=0.0003,OR 0.20;95% CI:0.08 to 0.48), LNM (P=0.0003,OR 0.64;95% CI. 0.50 to 0.81) and DM (P=0.0009,OR 0.28;95% CI. 0.13 to 0.59). Conclusions: DTC patients with gSMI had a higher risk of recurrence and LNM than those without ETE. However, in contrast with maximal ETE, a much better prognosis was observed in DTC patients with only gSMI. The findings of our meta-analysis provide supportive evidence for the validity of the T category changes in the 8th edition American Joint Committee on Cancer system. The actual impact of gSMI should be re-evaluated and revised in the recurrent risk stratification system in the future.

Preprint ARTICLE | doi:10.20944/preprints201805.0461.v1

Forecasting the Bladder Tumor Size and Immune Response of a Patient Over the Time Using a Dynamic Mathematical Model

Clara Burgos, Noemí García-Medina, David Martínez-Rodríguez, José-Luis Pontones, David Ramos, Rafael-J. Villanueva

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bladder cancer; dynamic model; uncertainty quantification; model calibration; cancer prognosis

Online: 31 May 2018 (08:18:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1627.v1

Neutrophil-Creatinine Index: A New Prognostic Factor for Severity of Acute Pancreatitis

Abdurrahman Sahin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: acute pancreatitis; neutrophil-creatinine index; neutrophil-to-lymphocyte ratio; prognosis; severity

Online: 25 October 2023 (10:06:31 CEST)

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Background and Objectives: The severity of acute pancreatitis (AP) is graded as mild (MAP), moderately severe (MSAP), and severe (SAP) according to the revised Atlanta Classification. Determining the severity of AP is the main goal in the early time of AP. The aim of this study was to compare laboratory parameters or indices including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and neutrophil-creatinine index (NCI) at admission for predicting severity of AP. Materials and Methods: In this retrospective study, the data from patients who admitted with diagnosis of AP between January 2018 and December 2021 were collected. Laboratory parameters and indices including NLR, PLR and NCI were compared in the discrimination of AP severity groups. Results: A total of 421 patients [MAP group (n=213), MSAP group (n=158) and SAP group (n=50)] were included. WBC count, neutrophil count, hematocrit, CRP, BUN, creatinine, NLR and NCI were significant parameters to discriminate AP subgroups. The AUROC analysis for discriminating MSAP from MAP showed that WBC (AUC: 0.723, 95% CI: 0.674-0.768, p<0.001), hematocrit (AUC: 0.566, 95% CI: 0.514-0.607, p=0.032), NLR (AUC: 0.649, 95% CI: 0.598-0.698, p< 0.001) and NCI (AUC: 0.749, 95% CI: 0.701-0.792, p<0.001) were statistically significant parameters. Similarly, AUCs to discriminate SAP from MSAP were (AUC: 0.649, 95% CI: 0.579-0.713, p < 0.001) for WBC, (AUC: 0.703, 95% CI: 0.621-0.785, p< 0.001) for BUN, (AUC: 0.602, 95% CI: 0.532-0.669, p=0.029) for CRP and (AUC: 0.742, 95% CI: 0.676-0.800, p<0.001) for NCI. Logistic regression analyses indicated that NCI was the only parameter to discriminate MSAP form MAP (OR: 1.119, 95% CI: 1.015-1.235, p=0.023) and SAP from MSAP (OR: 1.113, 95% CI: 1.042-1.888, p = 0.001). Conclusions: The present study enabled the identification of neutrophil-creatinine index as a new prognostic tool for the assessment AP severity at hospital admission.

Preprint ARTICLE | doi:10.20944/preprints202308.0686.v1

Estimated pulse wave velocity in the prediction of clinical outcomes in patients undergoing drug-eluting stent implantation

Hack-Lyoung Kiim, Hyun Sung Joh, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Joo-Hee Zo, Myung-A Kim

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: arterial stiffness; cardiovascular disease; percutaneous coronary intervention; prognosis; pulse wave analysis.

Online: 9 August 2023 (10:15:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0069.v1

The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications

Anna Puła, Paweł Robak, Damian Mikulski, Tadeusz Robak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: biology; drug resistance; gene expression profiling; mRNA; multiple myeloma; prognosis; treatment

Online: 5 October 2021 (08:20:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0711.v1

A Novel Approach for Early detection of Alzheimer's disease Based on Multi Level Fuzzy Neural Networks

Hamid Akramifard, MohammadAli Balafar, SeyedNaser Razavi, Abd Rahman Ramli

Subject: Social Sciences, Psychology Keywords: Alzheimer's disease; classification; early detection; Multi-Level Fuzzy Neural Networks; prognosis

Online: 29 March 2021 (17:09:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0330.v1

Detection of Rare Germline Variants in the Genomes of B Cell Neoplasms

Adrian Mosquera Orgueira, Miguel Cid Lopez, Andres Peleteiro Raindo, Jose Angel Diaz Arias, Beatriz Antelo Rodriguez, Laura Bao Perez, Natalia Alonso Vence, Angeles Bendaña Lopez, Aitor Abuin Blanco, Paula Melero Valentin, Roi Ferreiro Ferro, Carlos Aliste Santos, Maximo Francisco Fraga Martinez, Marta Sonia Gonzalez Perez, Manuel Mateo Perez Encinas, Jose Luis Bello Lopez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: germline; rare variant; cancer; lymphoid; B-cell; lymphomal; CLL; driver; prognosis

Online: 18 January 2021 (12:14:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0289.v1

Environmental Impact of Subsidy Concepts to Stimulate Car Sales in Germany

Malte Scharf, Ludger Heide, Alexander Grahle, Anne Syré, Dietmar Göhlich

Subject: Engineering, Automotive Engineering Keywords: subsidy; automotive industry; prognosis; COVID-19; environmental impact; life cycle analysis

Online: 10 November 2020 (08:20:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0484.v1

Expression of Intestinal Stem Cell and Cancer Stem Cell Markers in Submucosal Invasion and Its Prognostic Significance in Gastric Cancers

Hye Sung Kim, Hyun Joo Song, In Ho Jeong, Bo Gun Jang

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Gastric cancer; Submucosal invasion; Intestinal stem cell; Cancer stem cell; Prognosis

Online: 21 July 2020 (12:34:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0373.v1

The Hidden Story on Heterogeneous B-raf V600E Mutation Quantitative Protein Expression in Metastatic Melanoma – Association with Clinical Outcome and Tumor Phenotypes

Lazaro Hiram Betancourt, A. Marcell Szasz, Magdalena Kuras, Jimmy Rodriguez Murillo, Yutaka Sugihara, Indira Pla, Zsolt Horvath, Krzysztof Pawlowski, Melinda Rezeli, Kenichi Miharada, Jeovanis Gil, Jonatan Eriksson, Roger Appelqvist, Tasso Militois, Bo Baldetorp, Christian Ingvar, Håkan Olsson, Lotta Lundgren, Peter Horvatovich, Charlotte Welinder, Elisabet Wieslander, Ho Jeong Kwon, Johan Malm, Istvan Balazs Nemeth, Göran Jönsson, David Fenyo, Aniel Sanchez, György Marko-Varga

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malignant melanoma; BRAF V600E mutation; proteomics; mass spectrometry genetics; heterogeneity; prognosis

Online: 31 October 2019 (10:36:32 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0478.v1

Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine

Noriko Kimura, Kazuhiro Takekoshi, Mitsuhide Naruse

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: pheochromocytoma; paraganglioma; GAPP; metastasis; prognosis; catecholamine; gene mutation; immunohistochemistry; pathology; diagnosis

Online: 25 July 2018 (11:41:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0635.v1

Innate Immune Gene Polymorphisms and COVID‐19 Prognosis

Evangelos Bakaros, Ioanna Voulgaridi, Vassiliki Paliatsa, Nikolaos Gatselis, Georgios Germanidis, Evangelia Asvestopoulou, Stamatia Alexiou, Elli Botsfari, Vasiliki Lygoura, Olga Tsachouridou, Iordanis Mimtsoudis, Maria Tseroni, Styliani Sarrou, Varvara A. Mouchtouri, Katerina Dadouli, Fani Kalala, Simeon Metallidis, George Dalekos, Christos Hadjichristodoulou, Matthaios Speletas

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID‐19; IL18; TLR2; TLR4; CD14; CD40; CARD8; innate immunity; polymorphism; prognosis

Online: 8 August 2023 (11:53:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1636.v1

Clinical Decision Support Systems for brain tumour diagnosis and prognosis: a systematic review

Teesta Mukherjee, Omid Pournik, Sarah N. Lim Choi Keung, Theodoros N. Arvanitis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: clinical decision support system; brain tumour; brain neoplasms; diagnosis; prognosis; systematic review

Online: 22 June 2023 (14:59:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0206.v1

Evaluation of Baseline Characteristics and Prognostic Factors in Multisystemic Inflammatory Syndrome in Children: Is It Possible to Foresee the Prognosis in the First Step?

Benhur Sirvan Cetin, Ayşenur Paç Kısaarslan, Sedanur Tekin, Merve Basol Goksuluk, Ali Baykan, Başak Nur Akyıldız, Yılmaz Seçilmiş, Hakan Poyrazoglu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; multisystem inflammatory syndrome in children (MIS-C); risk classification; prognosis

Online: 14 June 2022 (11:12:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0096.v1

ColoSTEM Dx Kit: Innovative Alliance of Cancer Stem Cells and Glycosylation for Earlier Prediction of Colon Cancer Aggressiveness and Prognosis

Sabrina Blondy, Stéphanie Durand, Aurélie Lacroix, Niki Christou, Charline Bouchaud, Maud Peyny, Serge Battu, Alain Chaunavel, Vincent Carre, Marie-Odile Jauberteau, Fabrice Lalloue, Muriel Mathonnet

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Aggressiveness; biomarker; cancer stem cells; diagnosis; colon cancer; glycan; immunohistochemistry; lectin; prognosis

Online: 4 November 2021 (09:23:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0513.v1

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Jordan H. Whitlock, Tabea M. Soelter, Avery S. Williams, Andrew A. Hardigan, Brittany N. Lasseigne

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: liquid biopsy; epilepsy; circulating biomarkers; cfDNA; lncRNA; tRNA; miRNA; diagnosis; prognosis; therapeutics

Online: 26 August 2021 (16:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0729.v1

Prognostic Significance of CKS2 and CD47 Expression in Patients With Gastric Cancer Who Underwent Radical Gastrectomy

Yang zhou, Jing zeng, Haoran zhuang, wei zhou, keyan wu, weigan shen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gastric cancer; Cyclin-dependent protein kinase; Cluster of differentiation (CD) 47; Prognosis

Online: 31 May 2021 (10:13:20 CEST)

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Objective: To investigate the protein expression levels of cyclin‑dependent kinase subunit 2 (CKS2) and cluster of differentiation (CD) 47 in gastric cancer (GC) and their clinical significances. Methods: A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 patients with benign gastric tumor, 42 patients with low-grade intraepithelial neoplasia (LGIEN), and 49 patients with high-grade intraepithelial neoplasia (HGIEN) who underwent surgery were selected as the control groups. Immunohistochemistry was used to detect the expression of CKS2 and CD47 in surgical specimens. We statistically analyzed the clinical significance of the expression of the two factors. Results: (1) The positivity rates for CKS2 in benign gastric tumor tissue, LGIEN tissue, HGIEN tissue, and GC tissue gradually increased, i.e., 6.3% (2/32), 30.9% (13/42), 38.8% (19/49), and 60.3% (76/126), respectively, and the positivity rates for CD47 were 18.8% (6/32), 38.1% (16/42), 46.9% (23/49), and 65.9% (83/126), respectively. (2) High expression of CKS2 and CD47 were associated with tumor diameter, Lauren classification, number of lymph node metastases, and TNM stage. In addition, the immunohistochemical scores for CKS2 and CD47 were positively correlated (r=0.625, P=0.000). (3) The median follow-up time of 126 patients was 46.5 months, and the overall survival rate was 40.5% (51/126). Survival analysis showed that compared with that in the CKS2 (-) group, the overall survival rate for patients in the CKS2 (+) group was significantly worse (25.0% vs 64.0%, 2=15.67, P=0.000) and that compared with the CD47 (-) group, the CD47 (+) group had significantly worse overall survival (30.1% vs 60.5%, 2=15.67, P=0.000). (4) The overall survival rates of CKS2(+)CD47(+) group, CKS2(+)CD47(-) group, CKS2(-)CD47(+) group, and CKS2 (-)CD47 (-) group were 20.0%(13/65), 58.3%(7/12), 57.1%(8/14), 65.7% (23/35), respectively, the prognosis of patients in CKS2(+)CD47(+) group was significantly poor. Conclusion: High expression levels of CKS2 and CD47 were closely related to the occurrence of GC and can be used as independent risk factors to assess the prognosis of patients.

Preprint ARTICLE | doi:10.20944/preprints202101.0303.v1

Controlling Nutritional Status (CONUT) Score is a Prognostic Indicator for Patients with Hemorrhagic Stroke: Results from a 3-month Follow-up Study

Bei-lei Zhu, Yan-zhi Wu, Zhong-ming Cai, Cheng-wei Liao, Le-qiu Sun, Zhi-peng Liu, Hao-man Chen, Xue-rong Huang, Ren-qian Feng, Sheng-lie Ye, Qun-li Lin, Xu-dong Zhou, Man-man Zhang, Bo Yang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Controlling Nutritional Status Score; Hemorrhagic stroke; Nutrition screening; Prognosis; Modified Rankin Scale

Online: 15 January 2021 (16:08:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0154.v1

Advances in Prognostic Methylation Biomarkers for Prostate Cancer

Dilys Lam, Susan Clark, Clare Stirzaker, Ruth Pidsley

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA methylation; epigenetics; biomarkers; circulating DNA; cfDNA; prostate cancer; early detection; prognosis

Online: 7 October 2020 (09:27:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0258.v1

An Integrated Pan-Cancer Analysis and Structure-Based Virtual Screening of GPR15

Yanjing Wang, Xiangeng Wang, Yi Xiong, Cheng‐Dong Li, Qin Xu, Lu Shen, Aman Chandra Kaushik, Dong-Qing Wei

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: GPR15, pan-cancer, TCGA, cancer immunity, differential gene expression, prognosis, virtual screening

Online: 23 July 2019 (11:15:19 CEST)

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