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Preprint HYPOTHESIS | doi:10.20944/preprints202003.0021.v2

Bottleneck, Isolate, Amplify, Select (BIAS) as a Mechanistic Framework for Intracellular Population Dynamics of Positive Sense RNA Viruses

Feng Qu, Limin Zheng, Shaoyan Zhang, Rong Sun, Jason Slot, Miyashita Shuhei

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: virus; population bottleneck; positive sense RNA virus; evolution

Online: 1 October 2020 (08:28:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0212.v1

Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

Tessa Nelemans, Marjolein Kikkert

Subject: Biology And Life Sciences, Virology Keywords: positive-sense single-stranded rna viruses; innate immune evasion; type 1 interferon; viral pathogenesis; type 3 interferon

Online: 18 September 2019 (17:12:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0358.v1

Full-Length Genomic RNA of Foot-and-Mouth Disease Virus is Infectious for Cattle by Injection

Hanna Keck, Benedikt Litz, Bernd Hoffmann, Julia Sehl-Ewert, Martin Beer, Michael Eschbaumer

Subject: Biology And Life Sciences, Virology Keywords: Foot-and-mouth disease virus; safe sample transport; single-stranded positive-sense RNA; TRIzol extraction; naked RNA; infectivity; RNA transfection; lipofectamine; self-transfection; BHK cells

Online: 25 July 2022 (08:14:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0172.v4

Protein-Encoding RNA-to-RNA Information Transfer in Mammalian Cells: Principles of RNA-Dependent mRNA Amplification

Vladimir Volloch

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNA-dependent amplification of mammalian mRNA; physiologically occurring intracellular PCR, iPCR; RNA-dependent RNA polymerase, RdRp; chimeric RNA; sense-strand RNA; antisense-strand RNA

Online: 12 June 2019 (12:21:59 CEST)

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The transfer of protein-encoding genetic information from DNA to RNA to protein, a process formalized as the “Central Dogma of Molecular Biology”, has undergone a significant evolution since its inception. It was amended to account for the information flow from RNA to DNA, the reverse transcription, and for the information transfer from RNA to RNA, the RNA-dependent RNA synthesis. These processes, both potentially leading to protein production, were initially described only in viral systems, and although RNA-dependent RNA polymerase activity was shown to be present, and RNA-dependent RNA synthesisfound to occur, in mammalian cells, its function was presumed to be restricted to regulatory. However, recent results, obtained with multiple mRNA species in several mammalian systems, strongly indicate the occurrence of protein-encoding RNA to RNA information transfer in mammalian cells. It can result in the rapid production of the extraordinary quantities of specific proteins as was seen in cases of terminal cellular differentiation and during cellular deposition of extracellular matrix molecules. A malfunction of this process may be involved in pathologies associated either with the deficiency of a protein normally produced by this mechanism or with the abnormal abundanceof a protein or of its C-terminal fragment. It seems to be responsible for some types of familial thalassemia and may underlie the overproduction of beta amyloid in sporadic Alzheimer’s disease. The aim of the present article is to systematize the current knowledge and understanding of this pathway. The outlined framework introduces unexpected features of the mRNA amplification such as its ability to generate polypeptides non-contiguously encoded in the genome, its second Tier, a physiologically occurring intracellular polymerase chain reaction, iPCR, a Two-Tier Paradox and RNA Dark Matter. RNA-dependent mRNA amplification represents a new mode of genomic protein-encoding information transfer in mammalian cells. Its potential physiological impact is substantial, it appears relevant to multiple pathologies and its understanding opens new venues of therapeutic interference, it suggests powerful novel bioengineering approaches and its further rigorous investigations are highly warranted.

Preprint ARTICLE | doi:10.20944/preprints202105.0322.v1

Replication-Dependent Biogenesis of Turnip Crinkle Virus Long Noncoding RNAs

Shaoyan Zhang, Rong Sun, Limin Zheng, Feng Qu

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Virus; plant virus; long noncoding RNA; replication; positive sense RNA virus

Online: 14 May 2021 (11:01:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

Preprint CASE REPORT | doi:10.20944/preprints202103.0466.v1

The Role of White Matter Disconnection in the Symptoms Relating to the Anarchic Hand Syndrome: A Single Case Study

Valentina Pacella, Giuseppe Kenneth Ricciardi, Silvia Bonadiman, Elisabetta Verzini, Federica Faraoni, Michele Scandola, Valentina Moro

Subject: Social Sciences, Psychology Keywords: anarchic hand syndrome; DTI; white matter disconnection; lesion mapping; sense of agency; posterior lesions.

Online: 18 March 2021 (10:09:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0147.v1

Schizophrenia Phenomenology Revisited: Positive and Negative Symptoms are Strongly Related Reflective Manifestations of an Underlying Single Trait Indicating Overall Severity of Schizophrenia

Abbas Almulla, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia, positive symptoms, negative symptoms, inflammation, neuro-immune

Online: 10 July 2019 (11:02:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0188.v1

Immediate Effects of Quadriceps Muscle Kinesiology Taping on Joint Position Sense and Force Sense in Healthy Individuals

Mariam Maqsood, Márk Váczi

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: kinesiology tape; maximum isometric voluntary contraction; joint position sense; force sense; proprioception

Online: 10 March 2023 (08:50:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0160.v1

Targeted Therapeutic Options and Future Perspectives for HER2-Positive Breast Cancer

Angelica Ferrando-Díez, Eudald Felip, Anna Pous, Milana Bergamino Sirven, Mireia Margelí

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; HER2-positive; estrogen receptor positive; triple-positive; HER2-targeted therapy; immunotherapy

Online: 10 June 2022 (11:03:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0293.v2

Dethroning the Planetary Perspective: Dealing with Actually-Occurring Transformations Using Dialogical Sense-Making and Critical Phenomenology

Stephen Woroniecki, Victoria Wibeck, Kristin Zeiler, Björn-Ola Linnér

Subject: Arts And Humanities, Philosophy Keywords: sense making analysis; critical phenomenology; sustainability transformations

Online: 13 October 2022 (09:26:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0110.v1

The Link between ADHD and Antisocial Behavior: The Moderating Role of the Protective Factor Sense of Coherence

Haym Dayan, Mona Khoury-Kassabri, Yehuda Pollak

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ADHD; Antisocial Behavior; Sense of Coherence; Protective Factors

Online: 7 September 2022 (11:03:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0167.v1

Sense of Safety and Planning and Design Policies

Rangajeewa Ratnayake, Naduni Wickramaarachchi, Julie Rudner

Subject: Social Sciences, Safety Research Keywords: CBD; planning and design policies; sense of safety

Online: 26 February 2018 (12:07:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1216.v1

Exploration of the Feeling Sensing Analysis via Electrochemical In-Vitro Carbon Nano Tube Paste Tattoo Working Sensor

Jong wan Choi, Ji won Min, Sahng wook Kim, Jung Hyun Park, Suw Young Ly5

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Voltammetry, bio current, feeling sense, in vivo, brain wave

Online: 16 August 2023 (13:48:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0749.v1

The Mediating Role of Psychological Distress in Excessive Gambling Among Young People: A Four-Country Study

Ilkka Vuorinen, Atte Oksanen, Iina Savolainen, Anu Sirola, Markus Kaakinen, Hye-Jin Paek, Izabela Zych

Subject: Social Sciences, Psychology Keywords: psychological distress; loneliness; sense of mastery; adolescents; young adults

Online: 31 May 2021 (11:35:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0281.v1

Belonging, Strangerhood and Mobility: South Sudanese in a Rural Town, Victoria

Naduni Wickramaarachchi, Edgar Burns

Subject: Arts And Humanities, Humanities Keywords: migrants; sense of belonging; small town; stranger; South Sudanese

Online: 30 January 2018 (10:35:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1899.v1

Impact of Peripheral Magnetic Stimulation on Sensory Ataxic Paresis of Upper Extremity Early after Stroke: A Pilot Randomized Controlled Trial

Shigeru Obayashi, Rina Takahashi, Hirotaka Saito, Kazue Taguchi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: motor recovery; neurorehabilitation; proprioceptive impairment; position sense; thumb localizing test

Online: 30 October 2023 (10:32:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0626.v1

A High Efficacy DNA Vaccine Against Tilapia Lake Virus in Nile Tilapia (Oreochromis niloticus)

Nai-tong Yu, Wei-wei Zeng, Jian-hua Wang, Yu-liang Zhang, Xiu-chun Zhang, Zhi-xin Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: tilapia; negative-sense RNA virus; Tilapia lake virus; DNA vaccine

Online: 28 July 2021 (11:11:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0602.v1

On the Inconsistency of: The Classical Propositional Calculus and Its Metatheory

Lukasz Stepien

Subject: Computer Science And Mathematics, Logic Keywords: classical propositional calculus; zero-order logic; zeroth-order logic; consistency in the traditional sense; consistency in the absolute sense; inconsistency; metalogic; metatheory

Online: 8 December 2023 (10:31:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2199.v1

Hope Mediates Stress to Reduce Burden in Family Caregivers of Persons with Dementia

Jocelyn Shealy McGee, Edward C. Polson, Dennis Myers, Angela McClellan, Rebecca Meraz, Weiming Ke, Holly Carlson Zhao

Subject: Public Health And Healthcare, Other Keywords: Alzheimer's disease; dementia; cargiving; burden; hope; positive psychology; positive aspects of caregiving; stress; coping

Online: 28 December 2023 (14:36:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1895.v1

Bounded Number Theory: A Study on the Negation of Infinite Numbers in Parts or Completely

carlos eduardo ramos cardoso cardoso

Subject: Computer Science And Mathematics, Mathematics Keywords: limited number; different physical spaces; mathematics sense; number belongs to space

Online: 30 October 2023 (10:11:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1736.v1

The Influence of Urban Gardening Activities on Participants’ Perceived Restorativeness, Resilience, Sense of Community and Stress

Hee-Ran Kim, Won-Suk Oh, Jin Gun Kim, Won Sop Shin

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Urban Garden; Perceived Restorativeness; Resillience; Sense of Community; Stress; Salivary cortisol

Online: 25 May 2023 (05:10:25 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201911.0386.v1

How a Strategic Scoping Canvas Can Facilitate Collaboration between Partners in Sustainability Transitions

Seerp Wigboldus, Jan Brouwers, Herman Snel

Subject: Social Sciences, Area Studies Keywords: multi-stakeholder processes; sustainability transformations; sense-making; strategy; theory of change

Online: 30 November 2019 (09:52:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0282.v1

Ascertaining the Sense of Safety in Urban Neighborhood Streets: The Case of Kotahena, Sri Lanka

Sanduni Karunananda, Amanda Rajapakse, Rangajeewa Rathnayake

Subject: Social Sciences, Safety Research Keywords: environmental cues; fear of crime spots; sense of safety; social cues

Online: 1 February 2018 (07:59:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0943.v1

Revealing a Binary Pattern Validates 3n+1 Problem for All Positive Integers

Budee U Zaman

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Binary pattern,Positive integers ,Collatz conjecture

Online: 15 April 2024 (10:55:15 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints201911.0214.v1

Unbiasing in the Genome Analysis of Iconic Shark Species

Kazuaki Yamaguchi, Shigehiro Kuraku

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: shark; genome; longevity; gigantism; positive selection

Online: 18 November 2019 (07:46:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0053.v1

Theory of Relationships between Spaces to Obtain Numerical Knowledge

carlos eduardo ramos cardoso cardoso

Subject: Computer Science And Mathematics, Mathematics Keywords: relationships between spaces; numerical knowledge; sense of mathematics; odd and even numbers

Online: 1 November 2023 (09:46:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1289.v1

The Role of the Hippocampus Concerning Personal Narrative Construction and Mental Health Signifying Positive Health Outcomes Through a Narrative Development Process

Carol Nash

Subject: Social Sciences, Psychology Keywords: hippocampus; narrative; mental health; positive health outcomes

Online: 20 September 2023 (02:23:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0332.v2

Witnessing Evolution of SARS-CoV-2 through Comparative Phylogenomics: The Proximate Origin is Guangdong, not Wuhan

Özgül Doğan, Ertan Mahir Korkmaz, Mahir Budak, Battal Çıplak, Hasan Hüseyin Başıbüyük

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: coronavirus; substitution rate; positive selection; demographic dynamics

Online: 21 June 2020 (16:10:26 CEST)

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A new form of coronavirus called severe acute respiratory disease coronavirus type 2 (SARS-CoV-2) is currently causing a pandemic. A six-month evolutionary history of SARS-CoV-2 is witnessed by characterising the total genome of 821 samples using comparative phylogenomic approaches. Our analyses produced striking inclusive results that may guide scientists/professionals for the past/future of pandemic. Phylogenetic and time estimation analyses suggest the proximate origin of pandemic strain as Guangdong and the origin time as first half of September 2019, not Wuhan and December 2019, respectively. The viral genome experienced a substitution rate similar to other RNA viruses, but it is particularly high in some of the peptides encoding sequences such as leader protein, E gene, orf8, orf10, nsp10, N gene, S gene and M gene and nsp4, while low in nsp11, orf7a, 3C-like proteinase, nsp9, nsp8 and endoRNase. Most strikingly, the divergence rate of amino acid sequences is high proportional to nucleotide divergence. Additionally, specific non-synonymous mutations in nsp3 and nsp6 evolved under positive selection. The exponential growth rate (r), doubling time (Td) and R₀ were estimated to be 47.43 per year, 5.39 days and 2.72, respectively. Comparison of synapomorphies distinguishing the SARS-CoV-2 and the candidate ancestor bat coronavirus indicates that mutation pattern in nsp3 and S gene enabled the new strain to invade human and become a pandemic strain. We arrive at the following main conclusions: (i) six months evolution of viral genome is nearly neutral, (ii) origin of pandemic is not Wuhan and predates formal reports, (iii) although viral population is ongoing an exponential growth, the doubling time is evolving towards shortening, and (iv) divergence rate of total genome is similar to other RNA viruses, but it is prominently high in some genes while low in some others and evolution in these genes should be closely monitored as their protein products intervening to pathogenicity, virulence and immune response.

Preprint ARTICLE | doi:10.20944/preprints202308.1056.v1

Flood Perception from Local Perspective of Rural Community vs Geomorphological Control of Fluvial Processes in Large Alluvial Valley (the Middle Vistula River, Poland)

Daria Wiesława Krasiewicz, Grzegorz Wierzbicki

Subject: Environmental And Earth Sciences, Geography Keywords: sense of place; dyke; flood protection embankment; flood collective memory; suballuvial bedrock protrussion

Online: 15 August 2023 (08:42:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0790.v1

Does the High Level of Navigational Strategy Depend On the Number of Flight Hours or on an Innate Predisposition? The Case of Military Pilots

Marco Giancola, Paola Verde, Luigi Cacciapuoti, Gregorio Angelino, Laura Piccardi, Alessia Bocchi, Massimiliano Palmiero, and Raffaella Nori

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Cognitive style; Spatial Cognition; Sense of Direction; Spatial Orientation; Mental Rotation; Individual Differences

Online: 30 April 2021 (15:23:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0368.v1

The Role of Perceived Social Support in the Psychological Well-Being of Young Offenders: from Pretrial Detention to Correctional Camps

Fedor Ushkov, Roman Shilko, Ludmila Shaigerova, Alexandra Dolgikh, Olga Almazova, Olga Vakhantseva, Yuri Zinchenko

Subject: Social Sciences, Psychology Keywords: psychological well-being; young offenders; social support; pretrial detention; correctional camps; positive and negative feelings; positive and negative affects

Online: 29 November 2019 (04:16:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1429.v1

Impaired Regulation of Emotion in Bipolar Disorder: Behavioral and Neurophysiological Signatures

Mathilde Carminati, Frédéric Isel, Josselin Houenou, Michèle Wessa, Chantal Henry

Subject: Public Health And Healthcare, Other Keywords: bipolar disorder; emotion regulation; EEG; late positive potential

Online: 18 January 2024 (14:48:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0029.v1

Disentangling the Effects of Mindfulness, Savoring, and Depressive Symptoms among Emerging Adults

Rebecca Y. M. Cheung, Melody C. Y. Ng

Subject: Social Sciences, Psychology Keywords: savoring; mindfulness; depressive symptoms; emerging adults; positive experiences

Online: 2 March 2023 (04:11:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0784.v1

Artificial Compassion—From An AI Scholar

Cindy Mason

Subject: Social Sciences, Anthropology Keywords: Artificial Intelligence, Robots, Compassion, Human Sciences, Positive Plasticity

Online: 30 April 2021 (10:36:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1704.v1

Fruitlet Freeze Tolerance in Peach Germplasm

Ufuk Caglar, John Mark Lawton, Juan Carlos Melgar, Ksenija Gasic

Subject: Biology And Life Sciences, Horticulture Keywords: broad sense heritability; climate change; cold stress; electrolyte leakage; late spring frosts; Prunus persica.

Online: 22 December 2023 (04:56:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0054.v1

Early and Dynamic Socio-Academic Variables Related to Dropout Intention: A Predictive Model Made During Pandemic

Jorge Maluenda-Albornoz, Valeria Infante-Villagrán, Celia Galve-González, Gabriela Flores-Oyarzo, José Berríos-Riquelme

Subject: Social Sciences, Education Keywords: dropout intention; perceived social isolation; perceived social support; engagement; sense of belonging; higher education

Online: 3 December 2021 (13:08:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0288.v1

COVID-19 and Health Information Seeking Behavior: Digital Health Literacy Survey Amongst University Students in Pakistan

Rubeena Zakar, Sarosh Iqbal, Muhammad Zakria Zakar, Florian Fischer

Subject: Business, Economics And Management, Accounting And Taxation Keywords: eHealth Literacy; digital health literacy; sense of coherence; COVID-19; COVID-HL-Q; Pakistan.

Online: 10 March 2021 (15:07:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1525.v1

The Eﬀects of Idol Fans’ Interactions in Online Fan Community Platforms on Their Well-Being and Loyalty

Soyoung Wang, Min Sung Kim, Seongcheol Kim

Subject: Social Sciences, Media Studies Keywords: Fan community platform; Mental well-being; Sense of virtual community; Fan interaction; Parasocial relationship; Weverse

Online: 22 August 2023 (07:15:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1717.v1

Retrospective Review of Positive Newborn Screening Results for Isovaleric Acidemia and Development of a Strategy to Improve the Efficacy of Newborn Screening in the UK.

Rachel S Carling, Katy Hedgethorne, Anupam Chakrapani, Patricia L Hall, Nick Flynn, Toby Greenfield, Stuart J. Moat, Joshua Ssali, Lynette Shakespeare, Nazia Taj, Mark Anderson, Teresa H.Y. Wu, Arunabha Ghosh, Hugh Lemonde, Germaine Pierre, Mark Sharrard, Sreevidya Sreekantam, James R Bonham

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: isovaleric acidemia; false positive; newborn screening; inherited metabolic disease.

Online: 24 January 2024 (09:54:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0683.v1

Pathogenic Potential of Coagulase-Positive Staphylococcus Strains Isolated from Aviary Capercaillies and Free-Living Birds in South-Eastern Poland

Magdalena Sulikowska, Agnieszka Marek, Łukasz Sebastian Jarosz, Ewelina Pyzik, Dagmara Stępień-Pyśniak, Tomasz Hauschild

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: free-living birds; capercaillies; coagulase-positive Staphylococcus; virulence genes

Online: 9 January 2024 (05:25:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0726.v1

An Impact-Centered Sustainable Positive Experience Design Model

Chunmao Wu, Xuan Wang

Subject: Social Sciences, Psychology Keywords: Impact-centered design; sustainable design; positive experience; design model

Online: 13 October 2023 (07:11:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0237.v1

Positive Parenting and Sociodemographic Factors Related to the Development of Chilean Children Born to Adolescent Mothers

Laura Léniz-Maturana, Rosa Vilaseca, David Leiva, Rodrigo Gallardo-Rodríguez

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: adolescent mothers; positive parenting; child development; family sociodemographic factors

Online: 5 October 2023 (06:48:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1624.v1

On Positive Recurrence of M_n/GI/1/∞ Model

Alexander Veretennikov

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: M/GI/1/∞; positive recurrence; general service distribution function

Online: 25 September 2023 (05:37:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0116.v1

The Influence of Perceived Security in Childhood on Adult Self-Concept: the Mediating Role of Resilience and Self-Esteem

Juan Carlos Martín Quintana, Pedro Francisco Alemán Ramos, Paula Morales Almeida

Subject: Public Health And Healthcare, Other Keywords: Security; Attachment; Positive parenting; Resilience; Self-esteem; Self-concept

Online: 2 August 2023 (08:04:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0821.v1

On a System of Hadamard Fractional Differential Equations With Nonlocal Boundary Conditions on an Unbounded Domain

Rodica Luca, Alexandru Tudorache

Subject: Computer Science And Mathematics, Analysis Keywords: Hadamard fractional differential equations; nonlocal boundary conditions; positive solutions

Online: 11 May 2023 (08:29:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0041.v1

Employee Well-being in the Perspective of Positive Psychology and of the Job Demands-Resources Theory. The Role of Trust Within the Organization

Agnieszka Czerw, Damian Grabowski, Agata Chudzicka-Czupała, Katarzyna Stapor, Marta Żywiołek-Szeja

Subject: Social Sciences, Psychology Keywords: Well-being; Positive psychology; Organizational psychology; Job demands-resources

Online: 2 March 2023 (10:20:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0349.v1

Isoflurane Rescue Schizophrenia-related Deficits through Parvalbumin-positive Neurons in the Dentate Gyrus

Hualing Peng, Jie Jia, Yi-Sheng Lu, Hua Zheng

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: isoflurane; schizophrenia; adult neurogenesis; synaptic plasticity; parvalbumin-positive interneuron

Online: 23 September 2022 (02:05:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0431.v1

Management of Bladder Cancer Patients with Clinical Evidence of Lymph Node Invasion (cN+)

Bartosz Małkiewicz, Adam Gurwin, Jakub Karwacki, Krystian Nagi, Klaudia Knecht-Gurwin, Krzysztof Hober, Magdalena Łyko, Kamil Kowalczyk, Wojciech Krajewski, Anna Kołodziej, Tomasz Szydełko

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: bladder cancer; clinically positive lymph nodes; diagnosis; treatment; lymphadenectomy

Online: 25 August 2022 (10:05:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0012.v3

Quantifying Nature Positive

Anna-Mieke Mathilde Vlieg, Shadia Moazzem, Direshni Naiker, Delwyn Gloria Jones

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Nature-Positive; Quantified Benefit Assessment; Security; Wellness; Viability; Gain

Online: 21 April 2022 (17:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0576.v1

Acute Effect of Positive Airway Pressure on Heart Rate Variability in Obstructive Sleep Apnea

Ji Hye Shin, Min Ji Song, Ji Hyun Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Obstructive sleep apnea; heart rate variability; continuous positive airway pressure

Online: 9 November 2023 (09:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0968.v1

Multiple Positive Solutions for a Coupled System of Fractional Order BVP with p-Laplacian Operators and Parameters

Abdullah Ali H. Ahmadini, Mahammad Khuddush, Sabbavarapu Nageswara Rao

Subject: Arts And Humanities, Humanities Keywords: Fractional derivative; Positive solutions; Boundary value problems; p-Laplacian; parameters

Online: 14 September 2023 (09:45:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0506.v2

Effect of Continuous Positive Airway Pressure Given as Treatment for Obstructive Sleep Apnea on Central Corneal Thickness: Results at 12 Months

Pedro Naranjo-Bonilla, Estefania Mira-Padilla, María Carmen Muñoz-Villanueva, Bernabé Jurado Gámez, Rafael Giménez-Gómez

Subject: Medicine And Pharmacology, Ophthalmology Keywords: central corneal thickness; obstructive sleep apnea; continuous positive airway pressure

Online: 13 July 2023 (05:23:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0114.v1

Frequency-Shift of Quartz Crystal Microbalance Depends on the Length of Actin Filaments

Naoki Matsumoto, Honoka Kobayashi, Taiki Nishimura, Hideki Ashizawa, Takashi Kuwahara, Hajime Honda, Ikuko Fujiwara

Subject: Engineering, Bioengineering Keywords: quartz crystal microbalance; actin; positive frequency shift; physical property; biomolecule

Online: 3 May 2023 (08:14:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0277.v2

A Quantitative Poisitive Energy District Definition with Contextual Targets

Simon Schneider, Thomas Zelger, David Sengl, José Baptista

Subject: Environmental And Earth Sciences, Sustainable Science And Technology Keywords: Positive energy districts; PED definition; Context Factors; energy balance assessment

Online: 27 April 2023 (02:54:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0998.v1

Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV Positive and HIV Negative Individuals

Ariane Gomes Paixão, Marcos Abreu Almeida, Roberta Espírito Santo Correia, Beatriz Brittes Kamiensky, Rosely Maria Zancopé-Oliveira, Marcia dos Santos Lazera, Bodo Wanke, Cristiane da Cruz Lamas

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Histoplasmosis; Brazil; Epidemiology; HIV positive; AIDS; Immunosuppression; Culture; Serology; Mortality

Online: 26 April 2023 (14:58:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0816.v1

Characterization of Positive Invariance of Quadratic Convex Sets for Discrete Systems Using Optimization Approaches

Yuyao Lei, Hongli Yang, Ivan Ganchev Ivanov

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: discrete-time dynamic systems; positive invariance; ellipsoid; Lorenz cone; optimization

Online: 24 April 2023 (04:10:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0437.v1

Differences in Psychological Vulnerability, Mental Health Liter-Acy, Positive Mental Health, and Health Behaviours in Portu-Guese Higher Education Students: A Cross-Sectional Study

Maria José Nogueira, José Carlos Carvalho, Patrício Soares Costa, Carlos Alberto Sequeira

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: nursing health promotion; literacy; positive mental health; psychological vulnerability; students

Online: 27 March 2023 (03:34:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0357.v1

From Deficit to Strength-Based Aboriginal Health Research – Learning from those Who Flourish

Jonathan Bullen, Trish Hill-Wall, Kate Anderson, Alex Brown, Clint Bracknell, Elizabeth A. Newnham, Gail Garvey, Lea Waters

Subject: Social Sciences, Psychology Keywords: Aboriginal; First Nations; wellbeing; salutogenesis; flourishing; positive psychology; complex systems

Online: 21 February 2023 (09:09:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0196.v1

SARS-CoV-2 PCR Persistence and Duration of COVID-19 Symptoms in Health Professionals

Tatiana Schäffer Gregianini, Ludmila Fiorenzano Baethgen, Richard Steiner Salvato, Ivone Andreatta Menegolla, CEVS COVID-19 Team, Ana Beatriz Gorini da Veiga

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: SARS-CoV-2; PCR persistent positive; respiratory infection; COVID-19

Online: 12 December 2022 (09:04:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0515.v1

Positive Adult Education Learned Helplessness and the Pygmalion Effect

David Cobos-Sanchiz, Manuel-Jesús Perea-Rodriguez, Juan-Agustín Morón-Marchena, María-Carmen Muñoz-Díaz

Subject: Social Sciences, Education Keywords: Positive education; Pygmalion effect; learned helplessness; lifelong education; adult education

Online: 29 November 2021 (07:52:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0439.v1

One Possible Reinfection with SARS-CoV-2 Validated by 205-days Interval of Re-detection in Sapporo City, Japan

Toshiaki Asakura, Akiko Tamakoshi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; COVID-19; reinfection; re-detected positive; Japan

Online: 16 April 2021 (11:09:45 CEST)

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Working Paper BRIEF REPORT

Positive Rate Is Useful to Evaluate the Sufficiency of RT-PCR Test Availability for COVID-19

Sadao Suzuki

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; RT-PCR test; pre-test probability; positive rate

Online: 5 May 2020 (06:04:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0126.v1

Viral strategies of manipulating autophagy to benefit infection

Ho Him Wong, Sumana Sanyal

Subject: Biology And Life Sciences, Virology Keywords: Autophagy; positive stranded RNA virus; proviral autophagy; viral subversion strategies

Online: 10 May 2019 (14:00:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0305.v1

Influence of Congruency between Ideal Self and Brand Image on Sustainable Happiness

Jeongsoo Han, Mina Jun, Miyea Kim, Sookyoung Key

Subject: Business, Economics And Management, Marketing Keywords: sustainable happiness; ideal self; ideal social self; brand identification; positive

Online: 17 July 2018 (10:39:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0877.v1

A Challenge in A(G)I, Cybernetics Revived in the Ouroboros Model as One Algorithm for All Thinking

Knud Thomsen

Subject: Physical Sciences, Other Keywords: Ouroboros Model; Analogical Algorithms; AI-Challenge; Large Language Models; Cybernetics; Synergetics; Understanding; Common Sense; Consciousness; Free Will.

Online: 13 July 2023 (12:28:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0832.v1

What Am I Doing for (Their) a Living? Positive Impact and Innovative Behavior at Work: The Mediating Role of Needs Satisfaction

Konstantinos Papachristopoulos, Marc Antoine Gradito Dupord, Florence Jauvin, Jacques Forest, Patrick Coulombe

Subject: Social Sciences, Psychology Keywords: positive impact; needs satisfaction; prosocial motivation; benevolence; innovative work behavior; creativity

Online: 13 September 2023 (09:03:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0917.v1

On \Sigma-classes in E^8. IV. The neighbourhood of F_{22}

Peter Engel

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: lattice of translations, parallelohedra, cone of positive quadratic forms, \Sigma-subcones

Online: 13 July 2023 (10:00:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0024.v1

Indexing Inefficacy of Efforts to Stop Escalation of COVID Mortality

Ram Shanmugam, Lawrence Fulton, Jose Betancourt, Gerardo J Pacheco

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: Positive Poisson distribution, Under dispersion, Bayesian analysis, prediction, index of infectivity.

Online: 1 December 2022 (10:25:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0415.v1

Development of a Positive Psychology Well-Being Intervention in a Community Pharmacy Setting

Jennifer Louise Ward, Alison Sparkes, Ricketts Marie, Paul Hewlett, Amie-Louise Prior, Britt Hallingberg, Delyth Higman James

Subject: Social Sciences, Psychology Keywords: community pharmacy; well-being; positive psychology; public health; intervention; PERMA, diary.

Online: 22 November 2022 (09:44:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0053.v2

Protective Factors and Burnout Risk of Teachers During the COVID-19 Pandemic – A Two-Step Cluster Analysis

Camelia-Mădălina Răducu, Elena Stănculescu

Subject: Social Sciences, Psychology Keywords: COVID-19, positive emotionality, professional experience, selfcontrol, teacher burnout, well-being

Online: 26 October 2022 (09:37:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0164.v1

Neoadjuvant Pertuzumab plus Trastuzumab in Combination with Docetaxel and Carboplatin in Patients with HER2 Positive Breast Cancer: Real-World Data from a National Institute of Oncology in Poland.

Agnieszka Irena Jagiełło-Gruszfeld, Magdalena Rosinska, Malgorzata Meluch, Katarzyna Pogoda, Anna Niwińska, Renata Sienkiewicz, Aleksander Grous, Pawel Winter, Zbigniew I. Nowecki

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer,; neoadjuvant chemotherapy; elederly; HER2- positive; pathological complete response; safety

Online: 12 January 2022 (13:31:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0039.v1

Part 2 – Roots to Grow and Wings to Fly: An Ethnography of Psychosocial Development in Adolescent Performance Sport.

Sergio Lara-Bercial, Jim McKenna

Subject: Social Sciences, Psychology Keywords: Positive youth development, youth sport, realist evaluation, life skills, personal development.

Online: 5 January 2022 (12:40:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0172.v1

Enhancing the Positive Impact Rating: A New Business School Rating in Support of a Sustainable Future

Kathleen Rodenburg, Taimoor Rizwan, Ruifeng Liu, Julia Christensen Christensen Hughes

Subject: Business, Economics And Management, Business And Management Keywords: Positive Impact Rating (PIR); Sustainable Development Goals (SDGs); Rankings; Ratings, Biases

Online: 10 May 2021 (11:05:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0197.v1

Stability and Stabilization of Ecosystem for Epidemic Virus Transmission Under Neumann Boundary Value Via Impulse Control

Ruofeng Rao

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Neumann boundary value; positive equilibrium point; Poincare inequality lemma; impulse control

Online: 8 February 2021 (12:05:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0626.v1

Isolation and Identification of Gram Positive and Negative Bacteria from Dairy Department Waste Lines at Baraton University

Stella Wanyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Isolation; Identification; gram positive; gram negative; tests staining; microbio metabolic activities

Online: 25 November 2020 (08:36:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0491.v1

Cross-Sectional Study on Relationships Among FoMO, Social Influence, Positive Outcome Expectancy, Refusal Self-Efficacy and SNS Usage

KUNHUA LEE, Chia-Yu Lin, Jing Tsao, Lien Fang Hsieh

Subject: Social Sciences, Psychology Keywords: FoMO; Social Cognitive Theory; Social Influence; Self-efficacy; Positive Outcome Expectancy

Online: 21 July 2020 (12:57:49 CEST)

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Working Paper ARTICLE

Turkish Adaptation of the Positive-Negative Relationship Quality (PN-RQ) Scale: A Reliability and Validity Study

Arzu Araz, Duygu Güngör, Eda Aşçı

Subject: Social Sciences, Psychology Keywords: positive-negative relationship quality; reliability; validity; confirmatory factor analysis (CFA); bifactor

Online: 16 September 2019 (16:33:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0027.v1

Comparison of Smallest Eigenvalues for Nabla Fractional Boundary Value Problems

Jagan Mohan Jonnalagadda

Subject: Computer Science And Mathematics, Analysis Keywords: nabla fractional difference; boundary value problem; cone; u0- positive operator; eigenvalue

Online: 3 September 2019 (00:38:36 CEST)

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Working Paper ARTICLE

Interrogating Hope Theory

Jacob Shivley

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: interrogating hope theory, hope theory, hope, the hope scale, positive psychology

Online: 25 March 2019 (09:53:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0314.v1

From Individual Resource to Social Capital: The Mechanism of How Political Skill Affect Job Satisfaction and Turnover Intention

Yi Li, Mengqiu Ma

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: political skill; job satisfaction; turnover intention; popularity; positive affect; negative affect

Online: 26 December 2018 (12:16:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0102.v1

Age-Related Diseases as Vicious Cycles

Aleksey V. Belikov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: aging; age-related disease; mortality rate; positive feedback loop; vicious cycle

Online: 18 April 2017 (02:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0176.v1

The Severity of Traumatic Stress Associated with COVID-19 Pandemic, Perception of Support, Sense of Security, and Sense of Meaning in Life Among Nurses: Research Protocol and Preliminary Results from Poland

Grzegorz Józef Nowicki, Barbara Ślusarska, Kinga Tucholska, Katarzyna Naylor, Agnieszka Chrzan-Rodak, Barbara Niedorys

Subject: Public Health And Healthcare, Nursing Keywords: COVID-19; nurses; posttraumatic stress disorder; perceived social support; changes in outlook; sense of security; meaning in life

Online: 7 August 2020 (08:10:28 CEST)

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The COVID-19 pandemic affects not only physical health but also deteriorates mental health resulting in sleep problems, depression, and traumatic stress. Our research investigates the level of posttraumatic stress, perceived social support, opinions on positive and negative consequences of the pandemic, sense of security, and sense of meaning among nurses in the face of new and not fully understood global epidemiological phenomena. For this purpose, computer-assisted web interviewing methods were conducted between May 1 and May 15, 2020. Participating nurses completed the following research tools: The Impact Event Scale-Revised (IES-R), The Multidimensional Scale of Perceived Social Support (MSPSS), The Changes in Outlook Questionnaire (CIOQ), The Safety Experience Questionnaire (SEQ) and The Meaning in Life Questionnaire (MLQ). Three hundred and twenty-five nurses working throughout Poland joined the study of an average age of 39.18 ± 11.16 years. The average overall IES-R score in the study group was 1.78 ± 0.65. Among the dimensions of traumatic stress, the highest score was obtained in the dimension Avoidance 1.86 ± 0.73, then in the dimensions Hyperarousal 1.8 ± 0.78 and Intrusion 1.74 ± 0.83. Amongst studied nurses, the highest support rates were provided by significant others (22.58 ± 5.22), then from friends (21.91 ± 5) and family (21.45 ± 4.4). Among the surveyed nurses, higher average scores were noted in the subscale measuring positive psychological changes (18.56 ± 4.04). In contrast, a higher average level of assessment was noted on the Reflection on the safety dimension (4.21 ± 0.49). The mean MLQ score was 5.33 ± 0.87. A slightly higher result was observed in the subscale Presence (5.35 ± 1.14). The results of the research implemented during the period of severe psychological pressure associated with the COVID-19 pandemic provided information on symptoms of traumatic stress in the examined group of nurses. Their sense of security has been lowered and accompanied by an intensified reflection on issues concerning security. However, the sense of meaning (currently felt) in life remains higher than the tendency to searching for it. The surveyed nurses perceive individual support from the so-called significant others (apart from family and friends). They see positive changes resulting from painful experiences related to the COVID-19 pandemic, which can be characterized by adaptation in the form of posttraumatic growth.

Preprint ARTICLE | doi:10.20944/preprints202402.0249.v1

A Positive Experience Design Model: The Product Attachment Perspective

Chunmao Wu, Lili Chen

Subject: Arts And Humanities, Other Keywords: internalising positive experiences; product attachment; designing for well-being; systematic design models

Online: 5 February 2024 (13:28:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1877.v1

Nonlinear Differential Equation and SIS Epidemiological Model with a Time Delay Bounded by Two Positive Functions

Iveta Ilavská, Zuzana Malacká

Subject: Computer Science And Mathematics, Mathematics Keywords: nonlinear differential equation with time delay; SIS model; epidemiological model; positive solution

Online: 26 January 2024 (09:38:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1059.v1

Human Resources Management Development Regarding Work-Related Flow in Contrast to Either Happiness or PERMA Factors for Career Sustainability

Carol Nash

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: HRM; career sustainability; work-related flow; Csikszentmihalyi; happiness; PERMA; positive psychology; MDPI

Online: 15 January 2024 (10:27:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0437.v1

HER2 Positive Early Breast Cancer: Time for Ultimate De-escalation?

Nikolas Tauber, Christoph Cirkel, Anna Claussen, Franziska Fick, Emmanuel Kontomanolis, Natalia Krawczyk, Achim Rody, Maggie Banys-Paluchowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HER2 positive; Breast Cancer; Systemic De-Escalation; Chemo-free therapy; Targeted Therapy

Online: 5 January 2024 (06:47:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2328.v1

EMS for Active and Reactive Power Management in a Polygenerative Microgrid feeding a PED

Abhinav Sawhney, Federico Delfino, Barbara Bonvini, Stefano Bracco

Subject: Engineering, Electrical And Electronic Engineering Keywords: Microgrids; Optimization; EMS; E-mobility; V2G; Smart Grid; MILP; Positive Energy District

Online: 29 December 2023 (16:26:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1826.v1

Oral SERD, A Novel Endocrine Therapy for Estrogen Receptor-Positive Breast Cancer

Niraj Neupane, Sawyer Bawek, Sayuri Gurusinghe, Elham Moases Ghaffary, Omid Mirmosayyeb, Sangharsha Thapa, Carla Falkson, Ruth O’Regan, Ajay Dhakal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast cancer; Estrogen receptor-positive; endocrine therapies; resistance; selective estrogen degrades; Oral

Online: 29 November 2023 (08:15:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1720.v1

Exposure to Climate Change Information on Affect and Pro‐Environmental Behavioural Intentions: A Randomised Controlled Trial

Samantha Greaves, Caroline Harvey, Yashuhiro Kotera

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: climate change; positive and negative affect; pro-environmental behavioural intentions; climate anxiety

Online: 28 November 2023 (08:15:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1857.v1

Effect of Chest Physiotherapy with Threshold Valve in Hospitalized Adults with COVID-19 Pneumonia

Julia Estela, Emilio José Sánchez, Georgina Mateu, Elena Fernandez, Eva Robert, Silvia Pozo, Mariona Noray, Joan Carles Oliva, Fernanda Caballero, Manel Luján

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; pneumonia; hospitalized patients; chest physiotherapy; positive expiratory pressure; threshold valve

Online: 27 July 2023 (07:24:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0279.v2

COVID-19 Testing – Impact of Prevalence, Sensitivity, and Specificity on Patient Risk and Cost

Zoe C. Brooks, Saswati Das

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID19; risk; clinical; metrics; cost; false-positive; false-negative; prevalence; sensitivity; specificity

Online: 9 July 2020 (15:57:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0014.v1

Participating in HIV Prevention Clinical Trial: Reasons and Experiences among Female Participants in Antibody Mediated Prevention Study at UNC Project, Lilongwe, Malawi

Ruth Holla, Adamson Muula

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: HIV/AIDS; community health worker; clinical trial; informed consent; HIV positive; STI

Online: 2 May 2020 (13:45:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0225.v1

Analysis of Water Bodies under Partial Cloud Conditions Using Satellite Images

Rahul Neware, Mansi Thakare

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: water bodies; satellite images; vector data; SVM; positive and negative buffering; polygons

Online: 21 August 2019 (10:30:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0003.v1

Ventilation Positive Pressure Intervention Effect on IAQ in a School Building with Moisture Problems

Camilla Vornanen-Winqvist, Kati Järvi, Sander Toomla, Kaiser Ahmed, Maria A. Andersson, Raimo Mikkola, Tamas Marik, Laszlo Kredics, Heidi Salonen, Jarek Kurnitski

Subject: Engineering, Civil Engineering Keywords: ventilation; positive pressure; indoor air quality; mycobiota; indoor air questionnaire; moisture damage

Online: 1 December 2017 (07:06:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0206.v1

Genome Characterization of a Novel Binary Toxin-Positive Strain of Clostridium difficile and Comparison with the Epidemic 027 and 078 Strains

Zhong Peng, Sidi Liu, Xiujuan Meng, Wan Liang, Biao Tang, Yuanguo Wang, Juping Duan, Chenchao Fu, Bin Wu, Anhua Wu, Chunhui Li

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Clostridium difficile; ST201; binary toxin-positive; whole genome sequencing; comparative genomic analysis

Online: 30 May 2017 (06:15:11 CEST)

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A novel binary toxin-positive non-027, non-078 Clostridium difficile strain designated LC693 whose sequence type was ST201 was isolated from the fecal sample of a patient with severe diarrhea in China. To understand the pathogenesis basis of C. difficile ST201, this recently recovered isolate LC693 was then chosen for whole genome sequencing. The project finally generated an estimated genome size of approximately 4.07 Mbp. The genome sequence was then analyzed together with the other two ST201 strains VL-0104 and VL-0391 and compared to the epidemic 027/ST1 and 078/ST11 strains. Phylogenetic analysis demonstrated that the ST201 strains belonged to clade 3. Genome size of the three ST201 strains ranged from 4.07 Mb~4.16 Mb, with an average GC content between 28.5%~28.9%. The ST201 genomes contained more than 40 antibiotic resistance genes and 15 of them were predicted to be associated with vancomycin-resistance, suggesting that they may have a strong antibiotic resistance. The ST201 strains contained a typical clade 3 specific PaLoc with a Tn6218 element inserted, and those genes harbored on their PaLoc that participated in the toxin expression and regulation were highly homologues to the epidemic 027 and 078 strains, with the exception of tcdC. A truncated TcdC was found in the ST201 strains, which is suggestive to have a contribution to the toxin production of the ST201 strains. In addition, the ST201 strains contained intact binary toxin coding and regulation genes, which is also proposed to contribute to the virulence. Genome comparison of the ST201 strains with the epidemic 027 and 078 strain identified 641 genes specific for the C. difficile ST201, and a number of them were predicted as fitness and virulence associated genes. The identification of those genes also contributes to the pathogenesis of the ST201 strain. To our knowledge, this is the first study that the genome sequence of C. difficile ST201 was discussed in detail, and the present study would have a contribution to understanding the pathogenesis basis of C. difficile ST201.

Preprint COMMUNICATION | doi:10.20944/preprints202403.1065.v1

Descartes’ error with love

Jean-Olivier Durand

Subject: Social Sciences, Behavior Sciences Keywords: sex; pornography; wonderful body; love; positive emotions; homeostasis: Descartes’ error

Online: 19 March 2024 (10:14:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1458.v1

Rapid Review on the Concept of Positive Health and Its Implementation in Practice

Marja Van Vliet, Miriam De Kleijn, Karolien Van den Brekel, Tim Huijts, Sandra van Hogen-Koster, Hans Peter Jung, Machteld Huber

Subject: Public Health And Healthcare, Health Policy And Services Keywords: positive health; health; rapid review; shared decision making; health concept; transition; sustainable healthcare

Online: 19 January 2024 (07:53:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0054.v1

Play Behavior as a Positive Welfare Indicator for Farmed Spotted Paca (Cuniculus paca)

Allison Ferreira de Lima, Stella Guedes Calazans Lima, Sérgio L G Nogueira-Filho, Suzanne D. E. Held, Michael Mendl, Selene Siqueira da Cunha Nogueira

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: animal welfare; applied ethology; animal emotions; farmed animals; play behavior; positive welfare indicator

Online: 1 November 2023 (10:34:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0907.v1

Continuation of Radial Positive Definite Functions and Their Characterization

Fethi Bouzeffour

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Positive definite functions; completely monotone functions; Fractional integral and derivative; Fractional diffusion equation

Online: 11 August 2023 (12:54:09 CEST)

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