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Preprint ARTICLE | doi:10.20944/preprints202103.0088.v2

A Family Based Whole Exome Sequence Study to Indentify Modifier Genes for Phenotype Heterogeneity Between Severe and Non-Severe Thalassemia Patients

ANUPAM BASU, Dipankar Saha, Prosanto Kumar Chowdhury, , Debashis Pal, Kaustav Nayek, Gispati Chakrabortye, Surupa Basu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: WES; Thalassemia; phenotype

Online: 3 January 2023 (08:28:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1295.v1

Phenotypic Characterization of a Diverse Population of Cannabis sativa for Agronomic, Morphological, and Biochemical Traits

Éliana Lapierre, Maxime De Ronne, Rosemarie Boulanger, Davoud Torkamaneh

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: cannabis; breeding; phenotype; correlations

Online: 20 September 2023 (02:35:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0636.v1

Syncephalastrum massiliense sp. nov. and Syncephalastrum timoneanum sp. nov., Isolated from Clinical Samples

Jihane Kabtani, Fatima BOULANOUAR, Papa Mouhamadou GAYE, Muriel Militiello, Stéphane Ranque

Subject: Biology And Life Sciences, Other Keywords: Mucormycosis; Mucorales; Syncephalastrum; genotype; phenotype

Online: 11 October 2023 (03:35:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0903.v1

Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization

Fernanda Silva Almeida, Shayenne Eduarda Ramos Vanderley, Fernando Cézar Comberlang, Arthur Gomes de Andrade, Luiz Henrique Agra Cavalcante-Silva, Edson dos Santos Silva, Pedro Henrique de Sousa Palmeira, Ian P.G. do Amaral, Tatjana S. L. Keesen

Subject: Biology And Life Sciences, Parasitology Keywords: leishmaniasis; immune response; macrophage phenotype

Online: 25 April 2023 (08:36:54 CEST)

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Working Paper HYPOTHESIS

Competitive Coherence Generates Qualia in Bacteria and Other Living Systems

Vic Norris

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: consciousness; qualia; network; bacteria; learning; phenotype

Online: 15 September 2021 (15:58:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0210.v1

Common Connectivity Phenotypes in Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease: The Search for an Intermediate Phenotype

Craig A. Moodie, Kelvin O. Lim, Bryon A. Mueller, Laura S. Hemmy, Michael J. Howell, Paul J. Tuite

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s; RBD; connectivity; phenotype; classification; network

Online: 18 December 2018 (03:58:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0216.v1

SpainUDP: The Spanish Undiagnosed Rare Diseases Program

Estrella López Martín, Beatriz Martínez-Delgado, Eva Bermejo-Sánchez, Alonso Javier, Manuel Posada

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Diagnosis delay; rare diseases; undiagnosed programs; standardized phenotype; phenotype ontologies; whole exome analysis; international data sharing

Online: 13 June 2018 (15:41:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0235.v1

Alcohol: Epigenome Alteration and Transgenerational Effect

Nazila Heidari, Arman Hajikarim-Hamedani, Amirhossein Heidari, Yekta Ghane, Mitra-Sadat Sadat-Shirazi, Ghorbangol Ashabi, Mohammad-Reza Zarrindast

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alcohol; Ethanol; Epigenetics change; phenotype; offspring; Epigenome

Online: 4 July 2023 (13:25:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0378.v1

Frequency and Antibiotic Susceptibility Patterns of Streptococcus Agalactiae Strains Isolated from Women in Yaounde, Cameroon

Cécile Ingrid Djuikoue, Paule Dana Djouela Djoulako, Rodrigue Kamga Wouambo, Rosine Yemetio Foutsa, Dorine Ekeu, Teke Apalata

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Antibiotic resistance; Colonization; Prevalence; GBS; Resistance phenotype

Online: 22 August 2022 (08:04:16 CEST)

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Group B Streptococcus (GBS), a commensal in the body, causes a wide range of infectious diseases. The colonisation levels of GBS and its resistance profile to antibiotics provide important information useful for orienting prevention strategies. There is little data available on the subject with determination of resistance phenotypes in Cameroon. We therefore aimed to determine the prevalence of colonization, antibiotic resistance, including patterns of inducible resistance to clindamycin of GBS in Yaounde. To achieve this goal, a prospective cross-sectional study with an analytical component was carried out from the 28th June to the 29th August 2020 at the BIOSANTE laboratory and the Yaounde Gynaeco-Obstetrics and Paediatrics hospital. Vaginal swabs and urine were collected on 163 women. This samples were analysed using 5% defibrinated sheep blood agar and chocolate plus polyvitex agar. The isolates were identified using the morphology of the colony, Gram staining, haemolysis, catalase test and latex grouping test. Antibiotic susceptibility testing was done by disk diffusion method following the recommendations of the ACFSM 2019. The double disk diffusion method was used to identify isolates with clindamycin inducible resistance. Our data was analysed by the software SPSS version 2.1. The results obtained showed that the global prevalence of colonization by GBS was 37% (57/163), 40.35% in non-pregnant women and 59.65% in pregnant women. Pregnancy (P-value = 0.019) and gestational age (P-value = 0.025) constituted the risk factors of maternal colonization by GBS. In addition, the strains of GBS were resistant to all antibiotics tested. A D test showcased that 64.7% of GBS were resistant in a constitutive manner to clindamycin. We also note the presence of M phenotypes. As a whole, our results demonstrate that the rate of GBS colonization in this study was similar or higher than those in the previous report in Cameroon. All this indicates that attention should be paid to this bacterium in the monitoring of antimicrobial resistance and in the care of pregnant women and newborns.

Preprint REVIEW | doi:10.20944/preprints202010.0118.v1

From FAANG to Fork: Application of Highly Annotated Genomes to Improve Farmed Animal Production

Emily L Clark, Alan L Archibald, Hans D Daetwyler, Martien AM Groenen, Peter W Harrison, Ross D Houston, Christa Kuehn, Sigbjorn Lien, Daniel J Macqueen, James M Reecy, Diego Robledo, Mick Watson, Christopher K Tuggle, Elisabetta Giuffra

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: FAANG; farmed animal; genomics; genotype-to-phenotype

Online: 6 October 2020 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0034.v1

Phenotype, Genotype and Environment in Architecture Case Study: Traditional Malay House, West Borneo

Indah Kartika Sari, Wiendu Nuryanti, Ikaputra Ikaputra

Subject: Engineering, Architecture, Building And Construction Keywords: the building and the environment; phenotype; genotype

Online: 3 May 2020 (08:10:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0454.v1

Prevalence of Blood Groups in Eastern UP Population

Pradeep Kumar, Vandana Rai

Subject: Medicine And Pharmacology, Hematology Keywords: ABO blood groups; antigen; allele frequency; phenotype

Online: 29 February 2020 (08:26:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0089.v1

The Importance of a Multidisciplinary Approach in the Management of a Patient with Type I Gaucher Disease

Miguel-Ángel Torralba-Cabeza, Susana Olivera-González, José-Luis Sierra-Monzón

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: multidisciplinary; Gaucher; genotype/phenotype correlation; genetic counselling

Online: 5 July 2018 (08:51:35 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202311.1364.v1

Advocacy of Precision Allergy Molecular Diagnosis in Decision-Making for Eligibility of Customized Allergen Immunotherapy

Ruperto González-Pérez, Paloma Poza-Guedes, Fernando Pineda, Inmaculada Sánchez-Machín

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Mites; Allergen Immunotherapy; Molecular Allergology; Allergens; Allergic Phenotype

Online: 22 November 2023 (14:45:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1502.v1

Arabinose Plays an Important Role in Regulating the Growth and Sporulation of Bacillus subtilis NCD-2

Yifan Fu, Xiaomeng Liu, Zhenhe Su, Peipei Wang, Qinggang Guo, Ping Ma

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Phenotype Microarrays; Bacillus subtilis; L-arabinose; sporulation; transcriptome

Online: 24 October 2023 (13:28:42 CEST)

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Bacillus subtilis NCD-2 showed a promising biocontrol effect against plant soil-borne diseases, and was developed as a commercial microbial fungicide against cotton verticillium wilt in China. Spores were main ingredient of the fungicide and played the crucial role in biological control of plant diseases. Therefore, the key to reducing the cost of fungicide was to find ways to increase the number of spores of strain NCD-2 during fermentation. In this study, 755 substances were evaluated by Phenotype Microarray technology, and 5 kinds of carbon sources and 1 kind of nitrogen source were found to promote the metabolism of strain NCD-2. Among carbon sources L-arabinose showed strongest ability to promote the bacteria growth and sporulation of strain NCD-2. When L-arabinose was used as a single carbon source, it could increase the bacteria concentration and the sporulation efficiency of strain NCD-2 by 2.04 times and 1.99 times, respectively, compared with D-glucose. Moreover, L-arabinose could significantly decrease the autolysis of strain NCD-2 revealed by microscopy observation. The mechanism for promoting the sporulation by L-arabinose was analysed by RNA-seq sequencing. Results showed that total of 790, 923 and 1270 genes were up-regulated and 639, 850 and 1001 genes were down-regulated under L-arabinose supplies when cultured at 8 h, 12 h and 16 h, respectively. Fourteen differentially expressed genes associated with arabinose transportation and sporulation were selected for qRT-PCR analysis, and the result showed basically consistent expression trend with transcriptome. Notably, genes associated with arabinose metabolism, sporulation, spore resistance to heat and spore coat formation were significantly up-regulated, and genes associated with sporulation-delaying protein were significantly down-regulated under L-arabinose supplies. msmX gene which was involved in arabinose transport in Bacillus genus was deleted, and the mutant decreased the growth and sporulation by 53.71% and 86.46%, respectively, when compared to strain NCD-2 wild type. Complementary of the mutant by importing intact msmX gene could restore the growth and sporulation of the mutant strain. In conclusion, arabinose played an important role in regulating the growth and sporulation of strain NCD-2.

Preprint ARTICLE | doi:10.20944/preprints202307.1200.v1

Target soybean leaf automatic segmentation based on object detection and interactive segmentation models

Dong Wang, Zetao Huang, Haipeng Yuan, Yun Liang, Shuqin Tu, Cunyi Yang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: plant phenotype; soybean leaf; image segmentation; object detection

Online: 18 July 2023 (09:14:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1013.v1

Agricultural Sciences in the Big Data Era: Genotype and Phenotype Data Standardization, Utilization and Integration

Cecilia H. Deng, Sushma Naithani, Sunita Kumari, Irene Cobo-Simon, Elsa H. Quezada-Rodriguez, Maria Skrabisova, Nick Gladman, Melanie J. Correll, Akeem Babatunde Sikiru, Olusola O. Afuwape, Annarita Marrano, Ines Rebollo, Wentao Zhang, Sook Jung

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Genotype; phenotype; sequencing; phenomics; data integration; metadata; standardization

Online: 14 June 2023 (08:30:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0583.v1

A Systematic Review on Extreme Phenotype Strategies to Search for Rare Variants in Genetic Studies of Complex Disorders

Sana Amanat, Teresa Requena, Jose Antonio Lopez-Escamez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic association studies; extreme phenotype; genetic epidemiology; tinnitus

Online: 24 July 2020 (13:43:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1190.v1

Endotypes of Atopic Dermatitis: Correspondence to Classical Subtypes

Tsuyoshi Suzuki, Shumpei Kondo, Yasuaki Ogura, Masaki Otsuka, Yoshiki Tokura

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic dermatitis; endotype; extrinsic type; intrinsic type; subtype; phenotype

Online: 20 November 2023 (11:10:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1932.v1

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Jawad Nadeem, Amna Parveen, Sun Yeou Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Anti-aging, DNA damage response, senescence-associated secretory phenotype

Online: 28 September 2023 (04:56:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1133.v1

Tailored Therapy in Severe Asthma: The Importance of Moving beyond a Disease-Centric Approach

Andreas Photiades, Lamprini Vlassi, Chrysoula Kontogianni, Mina Gaga, Eleftherios Zervas

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: severe asthma; phenotype; endotype; personalized medicine; targeted therapy; treatment

Online: 15 June 2023 (11:35:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0316.v1

Type of ANCA may be Superior to Clinical Phenotype in Distinguishing Different Clinical Entities in ANCA-associated Vasculitis

Afroditi Maria Konstantouli, Georgios Lioulios, Asimina Fylaktou, Maria Stangou

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ANCA-associated vasculitis; Proteinase 3; Myeloperoxidase; Clinical Phenotype; Outcome

Online: 17 August 2022 (09:58:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1256.v1

TitleBiological Effects of “Inflammageing” on Human Oral Cells: Insights into a Potential Confounder of Age-Related Diseases

Elli Alexakou, Athina Bakopoulou, Danae A Apatzidou, Aristeidis Kritis, Andigoni Malousi, Vassiliki Anastassiadou

Subject: Biology And Life Sciences, Life Sciences Keywords: inflammageing; senescence; pro-inflammatory stimulus; Senescence Associated Secretory Phenotype (SASP)

Online: 20 November 2023 (16:15:05 CET)

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Objectives: The term "inflammageing” describes the process of inflammation-induced aging that leads living cells to a state of permanent cell cycle arrest due to chronic antigenic irritation. This in vitro study aimed to shed light on the mechanisms of “inflammageing” on human oral cells. Methods: Primary cultures of human gingival fibroblasts (hGFs) were exposed to variable pro-inflammatory stimuli, including lipopolysaccharide (LPS), Tumor Necrosis Factor-alpha (TNFa), and gingival crevicular fluid (GCF) collected from active periodontal pockets of systemically healthy patients. Inflammageing was studied through two experimental models, employing either late-passage (“aged”) cells (p.10) that were exposed to the pro-inflammatory stimuli or early-passage (“young”) cells (p.1) continuously exposed during a period of several passages (up to p.10) to the above-mentioned stimuli. Cells were evaluated for the expression of beta-galactosidase activity (histochemical staining), senescence-associated genes (qPCR analysis), and biomarkers related to a Senescence Associated Secretory Phenotype (SASP), through proteome profile analysis and bioinformatics. Results: A significant increase (p<0.05) of beta-galactosidase-positive cells was observed after exposure to each pro-inflammatory stimulus. The senescence-associated gene expression included upregulation for CCND1 and downregulation for SUSD6, and STAG1, a profile typical for cellular senescence. Overall, pro-inflammatory priming of late-passage cells caused more pronounced effects in terms of senescence, than long-term exposure of early-passage cells to these stimuli. Proteomic analysis showed induction of SASP, evidenced by upregulation of several pro-inflammatory proteins (IL-6, IL-10, IL-16, IP-10, MCP-1, MCP-2, M-CSF, MIP-1a, MIP-1b, TNFb, sTNF-RI, sTNF-RII, TIMP-2) implicated in cellular aging and immune responses. The least potent impact on the induction of SASP was provoked by LPS and the most pronounced by GCF. Conclusion: This study demonstrates that long-term exposure of hGFs to various pro-inflammatory signals induced or accelerated cellular senescence with the most pronounced impact noted for the late-passage cells. The outcome of this analyses provides insights into oral chronic inflammation, as a potential confounder of age-related diseases.

Preprint BRIEF REPORT | doi:10.20944/preprints202308.1537.v1

Optimal Protocols of Clinical and Genomic Data Collection for Prevention and Management of Congenital Anomalies

Heui Seung Jo, Misun Yang, So Yoon Ahn, Se In Sung, Won Soon Park, Ja-Hyun Jang, Yun Sil Chang

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital anomalies; newborns; whole genome sequencing analysis; protocol; phenotype; registry

Online: 22 August 2023 (07:59:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2120.v1

Impact of Obesity and Bariatric Surgery on Metabolic Enzymes and P-glycoprotein Activity using Geneva Cocktail Approach

Hengameh Ghasim, Mohammadreza Rouini, Saeed Safari, Farnoosh Larti, Mohammadreza Khoshayand, Kheirollah Gholami, Navid Neyshaburinezhad, Yvonne Gloor, Youssef Daali, Yalda H. Ardakani

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Phenoconversion; Bariatric surgery; CYP450 Phenotype and Genotype; Cocktail; Personalized medicine

Online: 30 May 2023 (10:59:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0488.v1

Primary Chemoradiotherapy Treatment (PCRT) for HER2+ and Triple Negative Breast Cancer Patients: A Feasible Combination

Raquel Ciérvide, Angel Montero Luis, Eduardo García-Rico, Mariola Garcia-Aranda, Mercedes Herrero, Jessica Skaarup, Leticia Benasi, Maria Jose Barrera, Estela Vega, Beatriz Rojas, Raquel Bratos, Ana Luna, Manuela Parras, Maria Lopez, Ana Delgado, Paloma Quevedo, Silvia Castilla, Margarita Feyjoo, Ana Higueras, Mario Prieto, Ana Suarez-Gauthier, Lina Garcia-Cañamaque, Nieves Escolán, Beatriz Alvarez, Xin Chen, Rosa Alonso, Mercedes Lopez, Ovidio Hernando, Jeannette Valero, Emilio Sánchez Sahugar, Eva Ciruelos, Carmen Rubio

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chemoradiation; preoperative; neoadjuvant; TN/HER-2+ phenotype; pathological response; breast cancer

Online: 29 August 2022 (10:47:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1417.v1

Phenotypic Differences among Recently Diagnosed Drug-Naïve Patients with Parkinson’s Disease with or without SNCA Polymorphisms

Santiago Pérez-Lloret, Alejandro Enet, Guenson Chevalier, Sofia Bordet, Hanny Barbar, Francisco Capani, Lucas Udovin, Matilde Otero-Losada, Francisco Barrantes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: single nucleotide polymorphism; Parkinson’s disease; alpha-synuclein; phenotype, pathophysiology; PD-related variants

Online: 20 July 2023 (12:46:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1450.v1

Oleocanthal Ameliorates Metabolic and Behavior Phenotypes in a Mouse Model of Alzheimer’s Disease

Euitaek Yang, Junwei Wang, Lauren N. Woodie, Michael W. Greene, Amal Kaddoumi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; blood-brain barrier; metabolic phenotype; sleep behavior; Promethion cages; oleocanthal

Online: 20 June 2023 (14:31:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0677.v1

Supervised Analysis for Phenotype Identification: The Case of Heart Failure Ejection Fraction Class

Cristina Lopez, Jose Luis Holgado, Raquel Cortes, Inma Sauri, Antonio Fernandez, Jose Miguel Calderon, Julio Nuñez, Josep Redon

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: heart failure, phenotype, left ventricular ejection fraction, primary care, artificial intelligence, supervised analysis

Online: 27 May 2021 (14:08:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0033.v2

Recent Trends of Antibiotic Resistance in Staphylococcus aureus Causing Clinical Mastitis in Dairy Herds in Abruzzo and Molise Regions, Italy

Franca Rossi, Ilaria Del Matto, Maria Antonietta Saletti, Luciano Ricchiuti, Lucio Marino

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Staphylococcus aureus; clinical mastitis; antibiotic resistance (AR) prevalence; AR phenotype; AR genotype; recent trend

Online: 22 January 2023 (06:50:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0187.v1

Sample Preservation and Plant Sex Prediction in White Guinea Yam (Dioscorea rotundata Poir.) Seedlings

Asrat Asfaw, Paterne Agre, Chidinma Nwachukwu, Bunmi Olasanmi, Jude Obidiegwu, Emmanuel Nwachukwu, Patrick Adebola, David De Koeyer

Subject: Biology And Life Sciences, Plant Sciences Keywords: dioecious; DNA quality; flower type; sample preservation method; sex genotype; sex phenotype; visual assay

Online: 14 February 2020 (04:22:20 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0185.v1

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Rostyslav Bubnov, Mykola Spivak

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: predictive preventive personalized medicine; Lactobacillus; Bifidobacterium; probiotics, gut microbiota; patient phenotype, individualized medicine; metabolic syndrome

Online: 11 September 2018 (06:00:03 CEST)

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The modification the gut microbiota in metabolic syndrome and associated chronic diseases is among leading tasks of microbiome research and needs for clinical use of probiotics. Evidence lack for the implications for microbiome modification to improve metabolic health in particular when applied impersonalized. Probiotics have tremendous potential in personalized nutrition and medicine to develop healthy diets. The aim was to to conduct comprehensive overview of recent updates of role of microbiota on human health and development of metabolic syndrome and efficacy of microbiota modulation considering specific properties of probiotic strain and particular aspects of metabolic syndrome and patient`s phenotype to fill the gap between probiotic product and individual to facilitate development of individualized / personalized probiotic and prebiotic treatments. We discuss the relevance of using host phenotype-associated biomarkers, those based on imaging and molecular and patrient`s history, reliable and accessible to facilitate person-specific appication of probiotics and prebiotic substances. Microbiome phenotypes can be parameters of predictive medicine to recognize patient`s predispositions and evaluate treatment responses; the number of phenotype markers can be effectively involved to monitor microbiome modulation. The studied strain-dependent properties of probiotic strains are potentially relevant for individualized treatment for gut and distant sites microbiome modulation. The evidence regarding probiotic strains properties can be taken to account via pathophysiology-based approach for most effective individualized treatment via gut, oral and vaginal and other sites microbiome modulation according to phenotype of the patient providing individualized and personalized medical approaches. Preventive potential of probiotics is strong and well-documented. Recommendations for individualized clinical use of probiotics, and for probiotic studies design have been suggested.

Preprint ARTICLE | doi:10.20944/preprints202108.0368.v1

An Investigation of Point Mutations Discovers Novel Genes and Their Corresponding Motifs in Pancreatic Cancer

Amin Ghareyazi, Amir Mohseni, Hamed Dashti, Abdollah Dehzangi, Hamid R. Rabiee, Hamid Alinejad-Rokny

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: pancreatic cancer; cancer subtype identification; somatic point mutations; genotype and phenotype characterization; therapeutic targets; personalized medicine

Online: 17 August 2021 (22:24:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0083.v1

Strengthening the Practical Application of Experiments Assessing Maize Drought Tolerance

Qinbin Zhang, Wei Wang

Subject: Biology And Life Sciences, Plant Sciences Keywords: drought-tolerance characteristics; maize breeding; maize drought tolerance; molecular markers; phenotype; screening of drought-tolerant plants

Online: 7 April 2020 (10:28:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201905.0330.v1

Cloudy with a Chance of Insights: Context Dependent Gene Regulation and Implications for the Evolution of Gene Expression

Elisa Buchberger, Micael Reis, Ting-Hsuan Lu, Nico Posnien

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: gene expression; gene regulation; evolution; allele specific expression; eQTL; RNAseq; ChIPseq; chromatin; ATACseq; genotype-phenotype map

Online: 28 May 2019 (10:29:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1046.v1

Effects of S-Adenosylhomocysteine-Hydrolase Down-Regulation on Wnt Signaling Pathway in SW480 Cells

Ivana Pavicic, Filip Rokic, Oliver Vugrek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: AHCY deficiency, S-adenosylhomocysteine (SAH), LEF1, STAT3, MYC, metastasis, EMT, cancer cell phenotype, shRNA, Next-generation sequencing,

Online: 15 September 2023 (11:03:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0242.v1

Genomic Fabric Remodeling in Prostate Cancer

Sanda Iacobas, Dumitru A. Iacobas

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: apoptosis; evading apoptosis; expression variability; cancer functional pathway; prostate cancer phenotype; immortality; proliferation; P53 signaling; transcriptomic network

Online: 9 March 2021 (08:44:15 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202005.0321.v2

Proposed O-GalNAc/Gal Gycosylation Pathways in Blood Group O and Non-O Blood Group Phenotypes During Plasmodium falciparum Infections Driving Evolution

Peter Arend

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: trans-species O-glycosylation; trans-species functional bridge; phenotype-specific plasma glycosylation; glycosidic exclusion; ontogenetic Tn formation

Online: 12 January 2021 (12:33:29 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202008.0574.v2

An Engineering Theory of Evolution

Simeon Castle, Claire Grierson, Thomas Gorochowski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: evolution; evotype; engineering theory; genotype-phenotype maps; directed evolution; selection; synthetic biology; bioengineering; evolvability; self-adaptive systems

Online: 9 December 2020 (10:51:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0733.v1

Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

Yi Yang, Milos Mihajlovic, Rosalinde Masereeuw

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; uremic toxins; renal tubular transport; extracellular matrix remodeling; apoptosis resistance; inflammatory response; senescence-associated secretory phenotype factors

Online: 9 August 2023 (10:49:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0192.v1

The Human Extracellular Matrix Diseasome Reveals Genotype-Phenotype Associations with Clinical Implications for Age-Related Diseases

Cyril Statzer, Karan Luthria, Arastu Sharma, Maricel G. Kann, Collin Y. Ewald

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Phenome; Matrisome; Matreotype; Phenotype; Extracellular Matrix; Data Mining; SNP; PheWAS; GWAS; Electronic Health Records; Drug Repurposing; Precision Medicine; Collagen; Human

Online: 10 March 2023 (09:34:15 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202309.2051.v1

The Underappreciated Role of Reproductively Lethal Mutations in the Evolution of Living Beings

Feng Qu, Khwannarin Khemsom, Camila Perdoncini Carvalho, Junping han

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Lethal mutation; reproductively lethal mutation; reproductive bottlenecking; evolution; natural selection; phenotype; asexual reproduction; sexual reproduction; virus; bacterium; plant; insect, animal; eusociality

Online: 29 September 2023 (08:24:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0186.v1

Roles of Extracellular Vesicles (EVs) Carrying HSPs in Cancer Biomarkers, Immune Surveillance, and Immune Evasion

Eman Taha, Kisho Ono, Takanori Eguchi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy

Online: 17 August 2019 (16:15:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1353.v1

D1-like and D2-like Dopamine Receptor of Rat Prefrontal Cortex: Impacts of Genetic Generalized Epilepsies and Social Behavioral Deficits

Lidia M Birioukova, Gilles Van Luijtelaar, Inna S Midzyanovskaya

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: dopamine; D1-like dopamine receptors; D2-like dopamine receptors; prefrontal cortex; generalized epilepsy; absence epilepsy; audiogenic epilepsy; animal model; autism spectrum disorder; phenotype

Online: 20 September 2023 (08:51:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0744.v1

Comparative Analysis of Frailty Identification Criteria on Continuous Non-invasive Neurocardiovascular Signals during an Active Stand Test in the Irish Longitudinal Study on Ageing (TILDA)

Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O’Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno

Subject: Engineering, Bioengineering Keywords: NIRS; Frailty; active stand; Frailty Phenotype; Frailty Index; Clinical Frailty Scale; cardiovascular; cerebrovascular; neurocardiovascular; statistical parametric mapping; SPM; blood pressure; heart rate; brain oxygenation; TSI

Online: 13 November 2023 (10:50:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1385.v1

Clinical Rationale for Dietary Lutein Supplementation in Post COVID-19 and mRNA Vaccine Injury Syndromes

Anthony M Kyriakopoulos, Greg Nigh, Peter A McCullough, Stephanie Seneff

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Lutein; post-COVID syndrome; mRNA vaccination injury syndrome; inflammatory response; reactive oxygen species; reactive nitrogen species; arrhythmogenic heart phenotype; antioxidant defense; bioavailability; extra virgin olive oil

Online: 20 September 2023 (10:07:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0386.v1

Exosome Release of Drugs: Coupling with Epithelial-Mesenchymal Transition

Takanori Eguchi, Kisho Ono, Stuart Calderwood, Kuniaki Okamoto

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology

Online: 29 December 2019 (13:46:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.1344.v1

Gray-Zone Lymphoma: A Still Open Issue

Stefano Pileri, Valentina Tabanelli, Chiarle Roberto, Angelica Calleri, Federica Melle, Giovanna Motta, Maria Rosaria Sapienza, Elena Sabattini, Pier Luigi Zinzani, Enrico Derenzini

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: mediastinal gray-zone lymphoma; classical Hodgkin lymphoma; primary mediastinal B-cell lymphoma; diffuse large B-cell lymphoma; NOS; EBV-positive diffuse large B-cell lymphoma; NOS; morphology; phenotype; gene expression profile; mutational landscape

Online: 18 May 2023 (12:25:07 CEST)

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