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Preprint REVIEW | doi:10.20944/preprints202212.0564.v1

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAMs) in Pharmaceuticals and Environmental Chemical Risk Assessment

Deepika Deepika, Vikas Kumar

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Physiologically Based Pharmacokinetic Model (PBPK); Drugs; environmental chemicals; Adverse outcome pathway (AOP); machine learning

Online: 30 December 2022 (01:30:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0261.v1

Unbiased Approach for the Identification of Molecular Mechanisms Sensitive to Chemical Exposures

Alexander Suvorov, Victoria Salemme, Joseph McGaunn, Anthony Poluyanoff, Menna Teffera, Saira Amir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: adverse outcome pathway; toxicity pathway; computational toxicology

Online: 21 June 2020 (11:10:34 CEST)

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Background: Targeted methods that dominated toxicological research until recently did not allow for screening of all molecular changes involved in toxic response. Therefore, it is difficult to infer if all major mechanisms of toxicity have already been discovered, or if some of them are still overlooked. Objectives: To identify molecular mechanisms sensitive to chemical exposures in an unbiased manner. Methods: We used data on 641,516 unique chemical-gene interactions from the Comparative Toxicogenomic Database. Only data from high-throughput gene expression experiments with human, rat or mouse cells/tissues were extracted. The total number of chemical-gene interactions was calculated for every gene, and used as a measure of gene sensitivity to chemical exposures. These values were further used in enrichment analyses to identify molecular mechanisms sensitive to chemical exposures. Results: Remarkably, use of different input subsets with non-overlapping lists of chemical compounds identified largely the same genes and molecular pathways as most sensitive to chemical exposures, indicative of an unbiased nature of our analysis. One of the most important findings of this study is that almost every known molecular mechanism may be affected by chemical exposures. Predictably, xenobiotic metabolism pathways and mechanisms of cellular response to stress and damage were among the most sensitive. Additionally, our analysis identified a range of highly sensitive molecular pathways, which are not widely recognized by modern toxicology as major targets of toxicants, including lipid metabolism pathways, longevity regulation cascade and cytokine mediated signaling. Discussion: Molecular mechanisms identified as the most sensitive to chemical exposures are relevant for significant public health problems, such as aging, cancer, metabolic and autoimmune disease. Thus, public health system will likely benefit from future research focus on these sensitive molecular mechanisms. Additionally, approach used in this study may guide identification of priority adverse outcome pathways (AOP) for in-vitro and in-silico toxicity testing methods.

Preprint ARTICLE | doi:10.20944/preprints202305.2092.v1

Technology-Based Issues in The New Education Policy of India

Nitish Ojha, Preetish Ranjan

Subject: Social Sciences, Education Keywords: NEP; new education policy; Indian education system; technology in education; outcome based education

Online: 30 May 2023 (10:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0653.v1

A New Approach in the Induction of Labor with Misoprostol Vaginal Insert in High-Risk Pregnancy Obese Women

Valentin Nicolae Varlas, Georgiana Bostan, Bogdana Adriana Nasui, Nicolae Bacalbasa, Anca Lucia Pop

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: misoprostol; induction of labor; high-risk pregnancy; obesity; diabetes; hypertension; perinatal outcome

Online: 25 November 2020 (16:41:16 CET)

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Background and objectives: Induction of labor (IOL) is an event that occurs in up to one-quarter of pregnancies; less is known about the outcomes and safety of IOL in obese pregnant woman; no data is available on misoprostol vaginal insert (MVI) IOL in high-risk pregnancy obese women. Objectives: (1) to evaluate the rate of successful IOL with 200 μg MVI in obese (Body Mass Index - BMI over 30 kg/m2) high-risk pregnant women: late-term pregnancy, hypertension or diabetes, compared to obese non-high-risk ones; (2) to evaluate the safety profile of MVI in high-risk pregnancy obese patients. Study design: We conducted a cross-sectional study in "Filantropia" Clinical Hospital, Bucharest, Romania, from June 2017 to September 2019 (28 months). From a total of 11,096 registered live births, IOL was performed in 206 obese patients; 74 obese high-risk pregnant patients matched the inclusion criteria; of these, 33.8% pregnancies (n=25) were late-term (41 – 41+6 weeks), 43.2% (n=32) had associated pathologies (hypertension and diabetes); labor induction was guided using a standardized protocol. We evaluated the maternal and gestational age, parity, fetal tachysystole, hyper-stimulation, initial cervical status, time from induction to delivery, drug side effects, mode of delivery, and neonatal outcomes. Results: (a) The overall successful labor induction rate, evaluated by the vaginal delivery rate, was 71.6% (n=53), spontaneously or instrumentally assisted; 28.4% (n=21) births were unsuccessful MVI IOL, converted into caesareans. (b) No significant differences were found regarding the maternal outcomes; in terms of perinatal outcomes of safety, four cases of high-risk pregnancies vaginally delivered were associated with neonatal intensive care unit (NICU) admissions and a one-minute Apgar score under seven (5.4%). Most cases with adverse effects of misoprostol have been managed conservatively, except for three emergency C-section cases. Conclusions: Misoprostol vaginal insert is a safe choice in IOL in obese high-risk pregnancies with good maternal and perinatal outcomes.

Preprint REVIEW | doi:10.20944/preprints202304.1108.v1

Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments

Ebru Altuntaş, Burcu Özkan, Sevgi Güngör, Yıldız Özsoy

Subject: Medicine And Pharmacology, Pharmacy Keywords: biopolymers; nanogels; drug delivery; polysaccharide-based nanogels; protein-based nanogels; nanotechnology

Online: 28 April 2023 (04:32:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0001.v1

The Pattern of Changes in Body Mass Index before and during Pregnancy: The Maternal and Neonatal Outcome

Gamal Sayed, Husam Salama, Lina Abdullah, Sawsan Al-Obaidly, Mai Al-Qubaisi, Ashraf Mansour

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: BMI; obesity; pregnancy; maternal outcome; neonatal outcome; Qatari women

Online: 3 April 2023 (02:07:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0288.v1

Predicting Idiosyncratic Volatility from Stock Market Trade Records: A Machine Learning Approach

Nasrin Seifi, Hassan S. Shavarani

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Idiosyncratic Volatility Estimation/Prediction; Machine Learning; Deep learning Based Regression; Tree-Based Regression; Artificial Intelligence

Online: 6 July 2023 (02:14:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1257.v1

Complex Systems Modelling: A Systematic, Quantitative Systems Engineering Approach

David Slater, Rees Hill

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: complex systems; model-based system engineering; FRAM ;

Online: 17 January 2024 (09:03:53 CET)

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In his Cynefin classification of system behaviours, Snowden (2007), posits that his Simple (Clear ) and even Complicated system categories are sufficiently understandable to be amenable to the traditional methods of system analysis and modelling. Here, relationships between entities in the system are clear and unambiguous and they behave predictably. So, we can build mathematical “models” to describe how the system is expected to function in different situations. Leaving aside his fourth category, Chaotic, as too hard for the moment, this paper focusses on the third category, Complex systems. Yaneer Bar-Yam [1998] defined "complex systems" as systems that "have multiple interacting components, whose collective behaviour cannot be simply inferred from the behaviour of components." So, the traditional system modelling approach of decomposition into components and attempting to build up a picture of system performance from individual pieces, alone, is no longer appropriate for this class. The problem is that most of the methods we currently employ, and particularly the methods that attempt to make the case that these systems are safe, (such as Fault trees, FMEA. and Root Cause Analysis), rely on this decomposition into components and attempt to make the parts more reliable individually. Even the more systemic approaches, such as Reason’s (1990) Swiss Cheese Model, and Leveson’s System Theoretic Analysis (STPA) (2004), encourage adding layers of protection, barriers, strengthened control loops and better safety critical systems, in the hope that they are making the systems safer. But without a valid model to test the effectiveness of these add-ons, we cannot be sure that they will not have an opposite effect, of making the systems even more complex, unreliable and unpredictable. For complex systems, the careful gathering and documentation of system components and their relationships is still a necessary first step, but we need an additional capacity to model these complex systems to test out and prove they work safely and successfully in the real world. (not just draw fixed component relationships as system “models” (wiring diagrams)) In the last 10 years, an original approach developed by Hollnagel, (2012), to model systems as sets of interactive, interdependent “functions”, (abstracted from and independent of component details), has now been developed to the point where it can take the basic data and structures from the current component focussed system engineering “models”, such as MBSE( Goldberg (1994)), and can pull it all together in a dynamic system model from which analysts can discern how it really works in practice, and predict the emergent behaviours characteristic of complex systems. The paper describes how this methodology developed and how it is currently used to model real situations, to analyse incidents and anticipate events.

Preprint ARTICLE | doi:10.20944/preprints202210.0192.v1

IndShaker: A Knowledge-based Approach to Enhance Multi-perspective System Dynamics Analysis

Salvatore Flavio Pileggi

Subject: Computer Science And Mathematics, Analysis Keywords: Knowledge-based Systems; Ontology; Knowledge Engineering; MCDA.

Online: 13 October 2022 (09:54:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0067.v1

The Impact of First Timing of Antibiotics for Community Acquired Pneumonia in Emergency Department

Yiwu Zhou, Casey M. Clements, Man Li, Yanqi He, Rong Yao

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Pneumonia; Timing; Antibiotics; Outcome

Online: 3 September 2020 (09:29:32 CEST)

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Working Paper ARTICLE

Prospective Systematic Data Collection in Early COVID-19 Patients: A Protocol for Individualized Treatment and Outcomes Research

Flávio Dantas

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Treatment outcome; Data Collection; Pharmaceutical Preparations; Outcome Assessment; Health Care

Online: 4 September 2020 (10:12:02 CEST)

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Human infection caused by the SARS-CoV-2 virus, called COVID-19, is a new pandemic with devastating effects worldwide. Science seeks the rational and systematic explanation of phenomena. In pandemics, decisions on prevention and treatment of people should be consistently taken, supported by scientific knowledge and ethical principles to produce more good than harm. At first, prospective observational studies to systematically collect patient data, correlating protective or therapeutic interventions with outcomes to assess effectiveness and safety, should be prioritized as the most appropriate type of study. The proposed protocol in this article aims to provide doctors with information on the reduction of harm in early COVID-19 patients by applying individualized interventionist or expectant therapeutic strategies, respecting the autonomy and preferences of physicians and patients in clinical decision-making. The evaluation of the clinical status, besides laboratory confirmation of COVID-19, comprises an individualized symptom score for each patient, a global self-perception scale of the severity of the disease, a clinical progression scale developed by the WHO for clinical studies in COVID-19 and, at the first consultation, doctors´ overall impression on the clinical prognosis. The analysis of anonymized data should preferably use descriptive and inferential statistical resources. The case report form is available for free use in the protocol, along with examples of patient informed consent forms for the prescription of off-label medications and authorization to use the data. Their results may be useful to indicate interventions that are candidates for efficacy trials, in randomized controlled trials, with a higher chance of success. It respects the autonomy and preferences of doctors and patients to decide the best options for treatment in uncertain situations. It also allows the gathering of useful information for future more rigorous clinical trials, trying to link science, ethics, and personal clinical experience.

Preprint ARTICLE | doi:10.20944/preprints201710.0032.v1

What do Users Really Want? Participatory Development of Decision Support Tools for Environmental Management based on Outcomes.

Richard J. Hewitt, C.J.A. Macleod

Subject: Social Sciences, Geography, Planning And Development Keywords: Environmental decision support systems; applications; outcome-based approach; adaptive management; user requirements; environmental management; participatory land planning

Online: 6 October 2017 (08:51:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0025.v1

Collective List-only Entity Linking: A Graph-based Approach

Weixin Zeng, Xiang Zhao, Jiuyang Tang

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: list-only entity linking; named entity disambiguation; graph-based approach

Online: 4 December 2017 (16:01:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0124.v1

A Novel Approach-Based Sparsity for Damage Localization in Functionally Graded Material

Emad Ghandourah, Kouider Bendine, Samir Khatir, Brahim Benaissa, Essam Mohammed Banoqitah, Abdulsalam Mohammed Alhawsawi, Essam B. Moustafa

Subject: Engineering, Mechanical Engineering Keywords: damage detection; sparsity-based approach; finite element; FISTA

Online: 4 July 2023 (03:31:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0164.v1

Maximising Classroom Environment by Blended Team-Based Teaching Approach with Continued Team Reallocation

Maryam Malekigorji

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: team-based learning; flipped classroom; team re-allocation

Online: 15 April 2019 (11:36:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0206.v1

Human-based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State-of-the-art with a Feto-placental Organ-on-a-chip Platform

Michaela Luconi, Miguel Angel Sogorb, Udo R. Markert, Emilio Benfenati, Tobias May, Susanne Wolbank, Alessandra Roncaglioni, Astrid Schmidt, Marco Straccia, Sabrina Tait

Subject: Biology And Life Sciences, Toxicology Keywords: new approach methodologies (NAMs); adverse outcome pathways (AOPs); endocrine disruptors; animal replacement; OECD TG 414

Online: 11 November 2022 (02:00:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0107.v1

On SINDy Approach to Measure-based Detection of Nonlinear Energy Flows in Power Grids with High Penetration IBR-based Renewables

Reza Saeed Kandezy, John Jiang, Di Wu

Subject: Engineering, Electrical And Electronic Engineering Keywords: Inverter-based resources; Measure-based method; Model identification; Non-linear dynamics; Power system; SINDy; Synchronous generators; System-level nonlinearity; Volterra-based nonlinearity index

Online: 1 November 2023 (17:22:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1016.v1

Emergency and Elective Colorectal Cancer – Relationship between Clinical and Biological Factors, Tumor Topography and Surgical Strategies. A Cohort Study

Ionut Simion Coman, Raluca Cristina Vital, Violeta Elena Coman, Cosmin Burleanu, Mircea Liţescu, Costin George Florea, Daniel Alin Cristian, Gabriel-Petre Gorecki, Petru Adrian Radu, Iancu Emil Pleşea, Anwar Erchid, Valentin Titus Grigorean

Subject: Medicine And Pharmacology, Surgery Keywords: colorectal; cancer; emergency; analysis; outcome

Online: 19 February 2024 (08:07:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1197.v1

Long-Term Outcomes in Patients Undergoing Thoracic Endovascular Aortic Repair. Single Center Experience

Aleksander Dokollari, Serge Sicouri, Gianluca Torregrossa, Roberto Rodriguez, Robert Meisner, Henry Hirsch, Vincent DiGiovanni, Alexander Uribe, Beatrice Bacchi, Francesso Cabrucci, Bruno Chiarello, Basel Ramlawi, Massimo Bonacchi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: TEVAR; long-term outcome; MACCE

Online: 16 August 2023 (09:17:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1834.v1

DIAG Approach: Introducing the Cognitive Process Mining by an Ontology-Driven Approach to Diagnose and Explain Concept Drifts

Sina NAMAKI ARAGHI, Franck FONTANILI, Arkopaul SARKAR, Elyes LAMINE, Mohammed-Hedi KARRAY, Frederick BENABEN

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: process mining; ontology; care pathways; digital thread; model-based system engineering; real-time location systems

Online: 25 December 2023 (08:22:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1582.v1

A Comprehensive Review on the Role of Resting State Functional Magnetic Resonance Imaging in Predicting Post-stroke Motor and Sensory Outcome

Foteini Christidi, Ilias Orgianelis, Ermis Merkouris, Christos Koutsokostas, Dimitrios Tsiptsios, Efstratios Karavasilis, Evlampia A. Psatha, Anna Tsiakiri, Aspasia Serdari, Nikolaos Aggelousis, Konstantinos Vadikolias

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: functional magnetic resonance imaging; resting-state functional connectivity; stroke; motor outcome; sensory outcome; biomarkers

Online: 20 December 2023 (21:49:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0242.v3

A Simulation Based Solution Approach for the Capacitated Lot-Sizing Problem With Remanufacturing

Luis Rocha

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: simulation based optimization; capacitated lot-sizing problem; heuristics; remanufacturing

Online: 21 April 2023 (09:46:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1279.v1

A Purely Entity-Based Semantic Search Approach for Document Retrieval

Mohamed Lemine SIDI, Serkan GUNAL

Subject: Computer Science And Mathematics, Information Systems Keywords: Keywords: Information Retrieval; Document Retrieval; Knowledge graphs; Entity-based Search; Entity Linking.

Online: 17 August 2023 (09:47:09 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.1188.v1

Community-Based Adaptation as a Transdisciplinary Approach and Instrument for a Social-Ecological Transformation

Tom Selje, Paul Strikker, Boris Heinz

Subject: Social Sciences, Other Keywords: community-based adaptation; transdisciplinary; critical realims; social-ecological transformation

Online: 17 April 2024 (15:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0241.v1

Analysis of Interest in Becoming Social Entrepreneurs among the Millennials and Z Generation Using the Theory of Planned Behavior and Outcome Expectation: A Multigroup Analysis Approach

Florentina Kurniasari, Elissa Dwi Lestari, Herlin Handayani

Subject: Social Sciences, Sociology Keywords: Attitude Toward Behavior; Subjective Norms; Perceived Behavioral Control; Outcome Expectation; Social Entrepreneurial Intention; Generation Z; Generation Millennials

Online: 14 February 2023 (09:01:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1373.v1

Development of Monthly Scale Precipitation Forecasting Model for Indian Subcontinent Using Wavelet Based Deep Learning Approach

Pavan Kumar Yeditha, Anusha Ganapathiraju, Siva Shyam Sai Nandikanti, Maheswaran Rathinasamy

Subject: Engineering, Civil Engineering Keywords: monthly precipitation forecast; wavelet-based machine learning; teleconnections

Online: 19 May 2023 (04:12:22 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202104.0070.v1

Dynamic-based Learning: A Novel Approach for Higher Education during COVID-19

Arnon Jumlongkul

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; dynamic-based learning; , higher education; interactive learning; online classroom

Online: 2 April 2021 (14:17:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2247.v1

Using a Metadata Approach to Extend the Functional Resonance Analysis Method to Model Quantitatively, Emergent Behaviours in Complex Systems.

Rees Hill, David Slater

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: Complex systems, model-based system engineering, FRAM

Online: 31 January 2024 (16:58:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0222.v1

Ensemble Machine Learning Approach for Evaluating the Material Characterization of Carbon Nanotube-Reinforced Cementitious Composites

Faramarz Bagherzadeh, Torkan Shafighfard

Subject: Engineering, Mechanical Engineering Keywords: machine learning; CNT-reinforced cement-based composites; mechanical attributes

Online: 15 March 2022 (16:50:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1983.v1

Spontaneous Cultural Conversion Rate of Mycobacterium avium Complex Pulmonary Disease Based on Baces Severity

Bo-Guen Kim, Jin Young Yu, Byung Woo Jhun

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Mycobacterium avium complex; outcome; treatment; severity

Online: 31 October 2023 (09:07:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1876.v1

The Clinical Implications of Serum Carbohydrate Antigen 19-9 Levels in Patients with Nontuberculous Mycobacteria Pulmonary Disease

Daegeun Lee, Byung Woo Jhun

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: nontuberculous mycobacteria; carbohydrate antigen; outcome; treatment

Online: 30 October 2023 (12:20:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0092.v1

Neutrophil Dynamics in Acute Coronary Syndrome

Patrick Maréchal, Julien Tridetti, Mai-Linh Nguyen, Odile Wéra, Zheshen Jiang, Maxime Gustin, Anne-Françoise Donneau, Cécile Oury, Patrizio Lancellotti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Acute coronary syndrome; inflammation; neutrophil; outcome

Online: 7 April 2020 (11:18:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0087.v1

Difference between Serum BNP Admission Level and that Detected at Discharge in Patients with ADHF Predicts Six-Month Mortality in a More Reliable Manner with Respect to Isolated BNP Determination Taken on Admission

Renato De Vecchis, Carmelina Ariano, Cesare Baldi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: natriuretic peptides; heart failure; congestion; outcome

Online: 9 August 2016 (11:33:03 CEST)

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Background According to some authors, a single isolated measurement of serum BNP executed on hospital admission would not be a sufficiently accurate method to predict the outcome of patients with ADHF. Aims For verifying this assumption, a retrospective study was conducted on patients hospitalized for ADHF. Our main objective was to ascertain whether there was any difference in midterm mortality among patients with rising BNP at discharge as compared to those with decreasing BNP at discharge. Methods Medical records were examined so as to make a partition of the ADHF patient population into two groups, the former characterized by a rise in BNP during hospitalization, and the latter exhibiting a decrease in BNP in the measurement taken at hospital discharge. Results 177 patients were enrolled in a retrospective study. Among them, 53 patients (29.94%) had increased BNPs at the time of discharge, whereas 124 (70.06%) showed decreases in serum BNP during their hospital stay. The group with patients who exhibited BNP increases at the time of discharge had higher degree of congestion evident in the higher frequency of persistent jugular venous distention and persistent orthopnea at discharge. Moreover, patients with increased BNP at the time of discharge had a lower reduction in inferior vena cava maximum diameter [1.58 ± 2.2 mm vs. 6.32 ± 1.82 mm; p (one-way ANOVA)=0.001]. In contrast, there was no significant difference in weight loss when patients with increased BNP at discharge were compared to those with no such increase. A total of 14 patients (7.9%) died during the six-month follow-up period. Cox proportional hazard analysis revealed that BNP increase at the time of discharge was an independent predictor of six-month all-cause mortality after adjustment for age, sodium at discharge, creatinine at discharge and New York Heart Association (NYHA) class at discharge (hazard ratio 34.49; 95% confidence intervals: 4.55–261.06; P =0.001). Conclusions Among patients with history of ADHF, more elevated BNP levels at the time of discharge from the hospital compared to those detected at admission identify a patient subset with higher grade of congestion and higher six-month mortality.

Preprint ARTICLE | doi:10.20944/preprints202403.1318.v1

Arguments for a Community Based Approach to the Geothermal Energy Development

Katarzyna A. Kurek, Jacek Strojny, Johan van Ophem

Subject: Business, Economics And Management, Other Keywords: geothermal energy; endogenous growth; green transition; energy based local economic system; geothermal community

Online: 21 March 2024 (15:00:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1684.v1

Adaptive Learning in Agent-Based Models: An Approach for Analyzing Human Behavior in Pandemic Crowding

David Romero, Paula Escudero

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Agent-based Modeling and Simulation; Reinforcement Learning; COVID-19; Social Simulation.

Online: 25 September 2023 (11:41:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0970.v1

The 10 “Cardinal Sins” in the Clinical Diagnosis and Treatment of Endometriosis: a Bayesian Approach

Philippe R Koninckx, Anastasia Ussia, Stephan Gordts, Jörg Keckstein, Ertan Saridogan, Malzoni Mario, Assia Stepanian, António Gutierrez Setúbal, Leila Adamyan, Arnaud Wattiez

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Endometriosis diagnosis; endometriosis therapy; endometriosis surgery; Bayesian statistics; evidence-based medicine

Online: 14 June 2023 (07:38:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0733.v1

Is Maternal Selenium Status Associated with Pregnancy Outcomes in Physiological and Complicated Pregnancy?

Joanna Pieczyńska, Rafał Sozański, Sylwia Płaczkowska, Halina Grajeta

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: selenium; GPX; pregnancy; pregnancy complications; pregnancy outcome

Online: 10 April 2024 (13:01:47 CEST)

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Selenium is essential for the synthesis and function of various selenoenzymes, such as glutathione peroxidases, selenoprotein P, and thioredoxin reductase, which play an important role in both antioxidant defense and limiting oxidative damage. Associations between serum selenium concentration and obstetric complications as well as pregnancy outcomes has been reported in many studies. The aim of this study was to determine whether the dietary intake of selenium, its concentration in serum and the activity of glutathione peroxidase in subsequent trimesters of pregnancy affect the birth condition of newborns assessed on the basis of the Apgar score in the 1st and 5th minute of life, birth weight, body length and head and chest circumference in physiological and complicated pregnancy course. Twenty-seven pregnant women at a mean age 29.6 ± 4.8 years from the Lower Silesia region of Poland were recruited to the study, 55% of studied group had pregnancy complications. The mean reported Se intake and serum selenium content for Polish pregnant women was in the first trimester – 56.53 μg/day and 43.75 μg/l, the second trimester – 61.79 μg/day and 41.77 μg/l and the third trimester – 58.37 μg/day and 42.13 μg/l, respectively. In the subgroup of pregnant women with a physiological pregnancy course, a weak, although statistically significant, positive correlation was found in the first trimester between Se intake and the length (R=0.48, p=0.019) and birth weight of newborns (R=0.472, p=0.022), and in the second trimester with the APGAR score at 1 (R=0.680, p=0.005) and 5 minutes (R=0.55, p=0.033), as well as in the third trimester with th APGAR score at 1 minut (R=0.658, p=0.019). The GPX value had a strong positive correlation with the APGAR score at 1 min. (R=0.650, p=0.008) in the second trimester and with the birth weight of the newborns (R=0.598, p=0.039) in the third trimester. There was no correlation between newborns' birth measurements and serum selenium concentration. In the subgroup of pregnant women with pregnancy complications, a strong, statistically significant, negative correlation was found between Se intake in the second trimester and gestational age (R=-0.618, p=0.032), and in the third trimester, a positive correlation between Se concentration in serum and head circumference (R=0.587, p=0.021). The obtained results indicate that there is a relationship between the maternal selenium status during pregnancy, both in terms of the intake of this element, its serum concentration as well as the glutathione peroxidase activity, and the anthropometric parameters of the newborn, such as birth weight, length and APGAR score, especially in the group with physiological course of pregnancy, but when pregnancy complications occur, these relationships lose their importance.

Preprint ARTICLE | doi:10.20944/preprints202307.0382.v1

Everyday Cardiac Surgery in Jehovah‘s Witnesses of Typically Advanced Age: Clinical Outcome and Matched Comparison

Martin Hartrumpf, Ralf-Uwe Kuehnel, Roya Ostovar, Filip Schroeter, Johannes M. Albes

Subject: Medicine And Pharmacology, Surgery Keywords: Jehovah’s Witnesses; cardiac surgery; outcome; transfusion; blood

Online: 7 July 2023 (09:58:24 CEST)

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Background and Objectives: Jehovah's Witnesses (JW) reject the transfusion of blood components based on their religious beliefs even if they are in danger of harm or death. In cardiac surgery, this significantly reduces the margin of safety and leads to ethical conflicts. Informed consent should be carefully documented and the patient's family should be involved. This study aims to compare the postoperative course of JW who underwent major cardiac surgery with a similar population of non-Witnesses (NW). Patients and Methods: Demographic, procedural, and postoperative data of all consecutive JW who underwent cardiac surgery at our institution were obtained from the records. They were compared with a propensity score matched group of NW. Anemic JW were treated with erythropoietin and/or iron as needed. Cardiac surgery was performed by experienced surgeons using median sternotomy and cardiopulmonary bypass. Common blood-sparing techniques were routinely used. Periprocedural morbidity and mortality were statistically evaluated for both groups. Results: 32 JW and 64 NW were part of the matched dataset showing no demographic or procedural differences. EPO was used preoperatively in 34.4% and postoperatively in 15.6% of JW but not in NW. Preoperative hemoglobin levels were similar (JW, 8.09±0.99 mmol/l; NW, 8.18±1.06; p=0.683). JW did not receive any transfusions except for one who revoked, while NW transfusion rates were 2.5±3.1 units for red cells (p<0.001) and 0.3±0.8 for platelets (p=0.018). Postoperative levels differed significantly for hemoglobin (JW, 6.05±1.00 mmol/l; NW, 6.88±0.87; p<0.001), and hematocrit (JW, 0.29±0.04; NW, 0.33±0.04; p<0.001) but not for creatinine. Early mortality was similar (JW, 6.3%; NW, 4.7%; p=0.745). There were more pacemakers and pneumonias in JW, while all other postoperative conditions were not different. Conclusions: Real-world data indicate that Jehovah's Witnesses can safely undergo cardiac surgery provided that patients are preconditioned and treated by experienced surgeons who use blood-saving strategies. Postoperative anemia is observed but does not translate into a worse clinical outcome. This is consistent with other studies.

Preprint ARTICLE | doi:10.20944/preprints202107.0680.v1

Characteristics of Surgical Necrotizing Enterocolitis: Is It Different from Medical Necrotizing Enterocolitis? A Single-Center Retrospective Study

Ara Cho, Dayoung Ko, JoongKee Youn, Hee-Beom Yang, Hyun-Young Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: NEC; Surgical; Medical; Risk factor; Outcome; Neonate

Online: 30 July 2021 (09:11:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0717.v1

Molecular Characterization of Ovarian Yolk Sac Tumor (OYST)

Khalil Hodroj, Aleksandra Stevovic, Valery Attignon, Domenico Ferraioli, Pierre Meeus, Sabrina Croce, Nicolas Chopin, Lea Rossi, Anne Floquet, Christine Rousset-Jablonski, Olivier Tredan, Frédéric Guyon, Isabelle Treilleux, Corinne Rannou, Marie Morfouace, Isabelle Ray-Coquard

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: OYST; molecular characteristics; targetable mutation; patients’ outcome

Online: 30 November 2020 (11:06:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0021.v1

Pioglitazone is Associated with Lower Major Adverse Cardiovascular and Cerebrovascular Events than DPP4-Inhibitors in Diabetic Patients with End-Stage Renal Disease: A Taiwan Nationwide Cohort Study, 2006-2016

Min-Hao Lin, Huang-Yu Yang, Chieh-Li Yen, Chao-Yi Wu, Chang-Chyi Jenq, George Kuo, Wei-Sheng Peng, Jia-Rou Liu, Ya-Chung Tian, Chih-Wei Yang, Gerard Anderson, Lai-Chu See

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pioglitazone; DPP4-inhibitor; ESRD; Cardiovascular outcome; Mortality

Online: 1 October 2020 (15:41:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0733.v1

Fluid-Structure Interaction in Coronary Stents: a Discrete Multiphysics Approach

Adamu Musa Mohammed, Mostapha Ariane, Alessio Alexiadis

Subject: Engineering, Automotive Engineering Keywords: Discrete multiphysics; smooth particle hydrodynamics; Lattice Spring Model; Fluid-structure interaction; particle-based method; Coronary stent; Atherosclerosis

Online: 30 June 2021 (11:55:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0521.v1

Introducing a Non-Invasive Monitoring Approach for Bridge Infrastructure with Ground-Based Interferometric Radar

Chris Michel, Sina Keller

Subject: Engineering, Automotive Engineering Keywords: displacement monitoring; ground-based interferometric radar; non contact measurement; structural health monitoring (SHM)

Online: 26 October 2020 (12:04:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0186.v1

Experimental and Density Functional Theory (DFT): a Dual Approach for the Adsorption of Cd (II) Ion from Aqueous Solution by Starch-Based Activated Carbon

Saad Melhi, Saeed Ullah Jan, Adnan Ali Khan, Khan Badshah, Saeed Ullah, Bushra Bostan, Zeliha Selamoglu

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: Adsorption; DFT; Starch-based Activated Carbon; Kinetics; Thermodynamics

Online: 12 October 2021 (14:58:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0007.v1

An Advanced Approach on Enhancing Accommodation Maintenance Via Text-Based Customer Review Analysis

Tharindu Wickramasinghe, Pumudu Fernando

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Machine Learning; Classification; Natural Language Processing; Text-based Customer Review Analysis; Sentiment Analysis; Deep Learning

Online: 1 May 2023 (03:21:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0750.v2

A New Approach Combining a Multilayer Radiative Transfer Model with an Individual Based Forest Model: Application to Boreal Forests in Finland

Hans Henniger, Friedrich J Bohn, Kim Schmidt, Andreas Huth

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: forest model; radiative transfer; vegetation indices; individual based; forest reflectance

Online: 12 June 2023 (03:41:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1310.v1

Incidence, Risk Factors and Consequences of Acute Kidney Injury in Patients Undergoing Esophageal Cancer Surgery: A Historical Cohort

Ilaria GODI, Paolo Feltracco, Giulia Lorenzoni, Alessio Antonelli, Renato Salvador, Dario Gregori, Ivo Tiberio, Michele Valmasoni

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: postoperative acute kidney injury; esophageal cancer surgery; outcome

Online: 23 February 2024 (10:32:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1946.v1

Direct Comparison of Elastic Stable Intramedullary Nailing and External Fixation for Managing Diaphyseal Femoral Fractures in Children: A Retrospective Analysis

Norbert Thomas, Ulrike Wittig, Thomas Boehm, Maximilian Burtscher, Harald Binder, Micha Komjati, Stephan Payr, Kambiz Sarahrudi, Thomas Manfred Tiefenboeck

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: children; diaphyseal femur fractures; external fixation; ESIN; outcome

Online: 28 September 2023 (09:39:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1518.v1

Comparative Analysis of Maternal and Neonatal Outcomes between Elective and Emergency Cesarean Section at a Single Tertiary Hospital

Nihal Al Riyami, Shurooq Al Shereiqi, Silja Pillai

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cesarean section; risk factors; pregnancy complications; pregnancy outcome

Online: 22 May 2023 (11:21:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0025.v1

A Cross sectional Observational Study of Safety and Protective Effects of Maternal Influenza Vaccination on Pregnancy and Birth Outcomes in pregnant women from Pune, India

Hanif Shaikh, Pranesha Koli, Anil Pardeshi, Vaishali Undale, Mahesh Asalkar, Sushant Sahatrabuddhe, Anand Kawade, Chandrashekhar Upasani

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Maternal immunization; influenza vaccination; pregnant women; pregnancy outcome

Online: 3 April 2023 (11:00:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0057.v1

Learning Ethical, Environmental and Professional Responsibil-Ity at Universitat Politècnica de València. Where Are We?

Ester Gimenez-Carbo, M. Esther Gómez-Martín, Ernesto Fenollosa, Marta Cabedo-Fabrés, Eloína Coll-Aliaga, Ignacio Andrés-Doménech, María-Teresa Sebastiá-Frasquet, María Vargas, Nuria Pascual-Seva, Alicia LLorca-Ponce, J. Felix Lozano, Antonio Martí-Campoy

Subject: Engineering, Automotive Engineering Keywords: cross-curricular learning outcome; ethical responsibility; environmental responsibility

Online: 2 July 2021 (14:13:00 CEST)

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Working Paper ARTICLE

Patterns, Management and Outcome of Traumatic Femur Fracture: Exploring the Experience of the Only Level 1 Trauma Center in Qatar

Syed Imran Ghouri, Mohammad Asim, Fuad Mustafa, Ahad Kanbar, Mohamed Ellabib, Hisham Al Jogol, Mohammed Muneer, Nuri Abdurraheim, Atirek Pratap Goel, Husham Abdelrahman, Hassan Al-Thani, Ayman El-Menyar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: femur fracture; orthopedic; trauma; management and outcome; Qatar

Online: 15 April 2021 (12:11:23 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202005.0253.v1

Outcomes Comparison of SpCas9- and LbCas12a-mediated DNA Editing in Zebrafish Embryos

Darya Meshalkina, Aleksei Glushchenko, Elana Kysil, Igor Mizgirev, Andrej Frolov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cas9; Cas12a; Cpf1; zebrafish; gene knockout; repair outcome

Online: 15 May 2020 (10:16:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0745.v1

Microbial Therapy and Breast Cancer Management: Exploring Mechanisms, Clinical Efficacy, and Integration Within the One Health Approach

Charalampos Filippou, Sophie C. Themistocleous, Giorgos Marangos, Yiannis Panayiotou, Maria Fyrilla, Christina A. Kousparou, Zoi-Dorothea Pana, Constantinos Tsioutis, Elizabeth O. Johnson, Andreas Yiallouris

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Microbiome; Breast Cancer; Microbial diversity; Microbiota-based cancer therapies; One Health; Microbiome immunomodulation

Online: 13 November 2023 (14:14:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0133.v1

A GIS Based Approach for Radiation Risk Assessment Around a Thermal Power Plant Towards Adopting Remedial Measures

Kajori Parial, S. Mukherjee, A. R. Ghosh, D. Sengupta

Subject: Engineering, Safety, Risk, Reliability And Quality Keywords: Radiation risk analysis, GIS based model, thermal power plant, surface radiation, remedial measures

Online: 11 December 2018 (13:57:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0229.v1

A Novel Framework for Production Planning and Class-Based Storage Location Assignment: Multi-Criteria Classification Approach

MEHMET AKİF YERLİKAYA, FEYZAN ARIKAN

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Order Picking; Class-Based Storage Location Assignment; Production Planning; TOPSIS; Decision Support System Flow

Online: 5 June 2023 (03:23:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1213.v1

Development of An Effective Corruption-Related Scenario-Based Testing Approach for Robustness Verification and Enhancement of Perception Systems in Autonomous Driving

Huang Hsiang, Yung-Yuan Chen

Subject: Engineering, Automotive Engineering Keywords: autonomous driving; corruption factors; perception system; robustness verification; scenario-based testing

Online: 20 November 2023 (07:24:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0035.v1

A Novel Hybrid Approach Based on Instance Based Learning Classifier and Rotation Forest Ensemble for Spatial Prediction of Rainfall-Induced Shallow Landslides Using GIS

Quang-Khanh Nguyen, Dieu Tien Bui, Nhat-Duc Hoang, Phan Trong Trinh, Viet-Ha Nguyen, Isık Yilmaz

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: landslide; classifier ensemble; instance based learning; Rotation Forest; GIS; Vietnam

Online: 4 May 2017 (08:25:12 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202101.0065.v1

Advanced Adverse Outcome Pathways Potentially Bridging the Pathogenesis of COVID-19

Youngjun kim, Chang Gyun Park, Sang Rak Lim, Indong Jun, Yong Oh Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; Angiotensin Converting Enzyme 2 (ACE2); Adverse outcome pathway(AOP); Molecular initiation Event (MIE); Key event (KE); Adverse Outcome (AO)

Online: 4 January 2021 (16:37:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1265.v1

How Technology-Based Interventions Can Sustain Ageing Well in the New Decade through the User-Driven Approach

Magdalen Velciu, Luiza Spiru, Mircea Dan Marzan, Eva Reithner, Simona Geli, Barbara Borgogni, Oana Cramariuc, Irina G. Mocanu, Jerzy Kołakowski, Jaouhar Ayadi, Margherita Rampioni, Vera Stara

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: active and healthy ageing; intrinsic capacity; user-centered design; eHealth literacy; technology-based interventions

Online: 18 May 2023 (04:48:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0447.v1

Critical Appraisal of Current Acute LBP Management and the Role of a Multimodal Approach

Magdi Hanna, Serge Perrot, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: low-back pain (LBP); guidelines; gaps; evidence-based; acute pain; analgesics; multimodal analgesia; fixed doses combination (FDC)

Online: 26 August 2022 (04:36:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0809.v1

Prognostic Significance of Physiological and Biochemical Parameters in Colic-Afflicted Equine

Indrė Mickevičienė, Donata Mikalauskienė, Dovilė Dambrauskaitė, Zoja Miknienė

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: colic syndrome; equine; prognostic; survival; outcome; physiological; parameters; biochemical

Online: 14 November 2023 (05:34:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0124.v1

The Impact of Body-Mass-Index on Functional Outcomes and Bleeding Volumes in Patients Suffering Non-Traumatic Intracerebral Haemorrhage

Stefan Wanderer, Attill Saemann, Basil Grüter, Sivani Sivanrupan, Julian Louis Muff, Donato D'Alonzo, Miriam Weiss, Angelo Tortora, Christian Musahl, Gerrit Schubert, Serge Marbacher, Lukas Andereggen

Subject: Public Health And Healthcare, Other Keywords: Body-mass-index; intracerebral haemorrhage; bleeding volume; functional outcome

Online: 3 October 2023 (10:35:39 CEST)

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The association between obesity and clinical as well as radiological outcomes in patients suffering non-traumatic intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective effect regarding in-hospital mortality. This study evaluates the impact of body mass index (BMI) on functional long-term outcome and bleeding volume in patients with non-traumatic ICH. A retrospective cohort study including all consecutive patients with spontaneous ICH treated at a tertiary referral centre between December 2017 and June 2021, aged 80 years or younger (n = 218), were included. Patients were dichotomized into overweight (OW, BMI ≥ 25 kg/m2) and normal weight (NW, BMI < 25 kg/m2). Functional outcomes were assessed by the modified Rankin scale (mRS), extended Glasgow Outcome Scale (GOS-E) and the National Institutes of Health Stroke Scale score (NIHSS) at 1, 3, 6 and 12-months follow-up. Bleeding volumes were calculated as ABC/2. Univariate and multivariate analysis were performed to assess clinical predictors of favourable outcome in the long-term. Of 218 patients (66.04 ± 15.18 years) suffering non-traumatic ICH, 115 (52.75%) were OW (29.72 ± 3.82). Female sex (p = 0.1), NIHSS (p = 0.69), cardiovascular risk factors (p = 0.55), ICH volume (p = 0.19), and presence of anticoagulation (p = 0.67) did not significantly differ between the OW and NW cohort. At discharge, functional outcome did not significantly differ between both cohorts (NW, mRS 3.92 ± 2.54 vs. OW, mRS 3.21 ± 2.43, (p = 0.28)). Multivariate analysis revealed that haemorrhage volume (p = 0.01) was the only robust risk factor to predict functional outcome after 1 year. Our data suggests that in ICH patients, neither obesity nor patient’s age are negative predictors for functional outcome in the long-term. Instead, bleeding volume is a robust risk factor predicting poor functional status after ICH. Therefore, prospective randomized trials analysing this coherence are highly warranted.

Preprint ARTICLE | doi:10.20944/preprints202308.1569.v1

Cross-cultural adaptation, reliability, and validity of the Polish version of the Neck Outcome Score

Nicola Dyrek, Łukasz Pulik, Aleksandra Piwowarczyk, Wiktoria Skała, Nina Grabowska, Paweł Łęgosz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Cervical Pain; Patient-Reported Outcome Measure; Validation Study; Poland

Online: 22 August 2023 (11:33:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2045.v1

Evolving a Model for Cochlear Implant Outcome

Ulrich Hoppe, Anne Hast, Joachim Hornung, Thomas Hocke

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Word Recognition; CI Outcome; prediction; generalised linear model; adults

Online: 31 July 2023 (11:47:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1454.v1

Effects of Vasopressin Receptor Agonists During the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies

Eleni Laou, Nikolaos Papagiannakis, Androniki Papadopoulou, Theodora Choratta, Minas Sakellakis, Mariachiara Ippolito, Ioannis Pantazopoulos, Andrea Cortegiani, Athanasios Chalkias

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: vasopressin; vasopressin receptor agonist; hemorrhagic shock; resuscitation; hemodynamics; outcome

Online: 20 June 2023 (14:57:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2082.v1

Characteristics Associated with Major Complications and Refractory Course in Patients with Osteomyelitis of the Jaw: Clinical, Radiological, and Bacteriological Features of 54 Patients

MATHILDE FENELON, Steven Gernandt, Romain Aymon, PAOLO SCOLOZZI

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Bone; Osteomyelitis; Decortication; Treatment Outcome; Oral and Maxillofacial Surgery

Online: 30 May 2023 (08:16:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0916.v1

Diagnostic and Prognostic Roles of Procalcitonin and Other Markers in Pneumonia: A Literature Update

Sedat OZBAY, Mustafa AYAN, Ozgur Karcioglu

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: pneumonia; bacteremia; sepsis; procalcitonin; diagnosis; biomarker; outcome; antibiotic stewardship

Online: 25 April 2023 (10:00:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0390.v1

Prospective Evaluation of the Weekend Effect on Mortality Outcomes in Aortic Dissection

Cosmin Banceu, Marius Harpa, Klara Brinzaniuc, Nicolae Neagu, Dan Alexandru Szabo, Diana Banceu, Marvin Oprean, Hussam Al Husseim, Daiana Cristutiu, Alexandru Antoniu Stan, Marius Neamtu Halic, Horatiu Suciu

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aortic dissection outcome; weekend effect; aortic dissection risk factor

Online: 22 March 2023 (03:29:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202208.0316.v1

Type of ANCA may be Superior to Clinical Phenotype in Distinguishing Different Clinical Entities in ANCA-associated Vasculitis

Afroditi Maria Konstantouli, Georgios Lioulios, Asimina Fylaktou, Maria Stangou

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ANCA-associated vasculitis; Proteinase 3; Myeloperoxidase; Clinical Phenotype; Outcome

Online: 17 August 2022 (09:58:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0223.v1

Characteristics of Nephroblastoma / Nephroblastomatosis in Children With a Clinically Reported Underlying Malformation or Cancer Predisposition Syndrome

Nils Welter, Angelo Wagner, Rhoikos Furtwängler, Patrick Melchior, Leo Kager, Christian Vokuhl, Jens-Peter Schenk, Clemens Magnus Meier, Stefan Siemer, Manfred Gessler, Norbert Graf

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nephroblastoma; clinical malformations; cancer predisposition syndromes; tumor surveillance; outcome

Online: 10 August 2021 (09:55:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0167.v1

Predictive Utility of Changes in Optic Nerve Sheath Diameter after Cardiac Arrest for Neurologic Outcomes

Heekyung Lee, Joonkee Lee, Hyungoo Shin, Changsun Kim, Hyuk Joong Choi, Bo Seung Kang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Heart arrest; optic nerve sheath diameter; Patient outcome assessment

Online: 10 May 2021 (10:51:42 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202101.0573.v1

Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework

Penny Nymark, Magdalini Sachana, Sofia Batista-Leite, Jukka Sund, Catharine E Krebs, Kristie Sullivan, Stephen Edwards, Laura Viviani, Kate Willett, Brigitte Landesmann, Clemens Wittwehr

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Adverse Outcome Pathways; COVID-19; mechanisms; systematic organization; interdisciplinary

Online: 27 January 2021 (17:01:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0392.v1

Comparison of Renin–Angiotensin–Aldosterone System Inhibitors with Other Antihypertensives in Association with Coronavirus Disease-19 Clinical Outcomes: Systematic Review and Meta-Analysis

Yihienew M. Bezabih, Alemayehu Bezabih, Endalkachew Admassie, Gregory M. Peterson, Woldesellassie Bezabhe

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: RAAS inhibitors; COVID-19; coronavirus; angiotensin; clinical outcome; antihypertensive

Online: 24 May 2020 (17:48:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0269.v1

Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria

Maria-Lauretta Orji, Nnamdi Onyire, Uche Unigwe, Nnennaya Ajayi, Demian Nwidi, Elizabeth Odey, Joseph Agboeze, Chiedozie Ojide, Fortune Ujunwa, Emeka Onwe, Robinson Onoh, Precious Madume

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: case fatality; Lassa virus; pattern; positivity rate; outcome; ribavirin

Online: 16 May 2020 (16:41:27 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201909.0081.v1

Prenatal Mercury Exposure and Postnatal Outcome: A Case Series in Bogotá, Colombia

Nelsy Niño-Rodríguez, María Margarita Manrique Andrade, Diana María Perez-Castiblanco, Cesar Alejandro Geney, Diana Patricia Castro Aguilar, Adriana Ruíz, Angélica María Téllez, Luis Jorge Hernández-Florez, Oscar Andrés Bociga, Helena Groot de Restrepo, Diana María Narváez

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: mercury; prenatal exposure; postnatal outcome; environmental health; epidemiological monitoring

Online: 7 September 2019 (01:06:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0089.v1

‘All I Ever Want to Eat is Pizza and Pasta’: Italian Food Temptations Associated with Adverse Perinatal Outcomes

Stefania Triunfo, Roberta Mayer, Michelangela Danza, Antonio Lanzone

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Fook intake; pizza; pasta; vegetables; pregnancy; adverse perinatal outcome

Online: 8 April 2019 (11:35:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0010.v1

Emotional Performance of a Low-Cost Eco-Friendly PBL Methodology for Science Education. Approach in Prospective Teachers

Míriam Andrea Hernández-Barco, Jesús Sánchez-Martín, Florentina Cañada-Cañada, Isaac Corbacho-Cuello

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Project Based Learning; Scientific education; Preservice primary teacher; Emotions; Active Methodologies; Higher Education for Sustainable Development

Online: 1 March 2021 (13:13:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0326.v2

Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture

Natalie Rubio, Isha Datar, David Stachura, Kate Krueger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cellular agriculture; cell-based seafood; fish tissue culture; bioreactor; serum-free media; ocean conservation; marine cell culture; aquaculture

Online: 25 January 2019 (11:36:58 CET)

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Cellular agriculture is defined as the production of agricultural products from cell cultures rather than from whole plants or animals. With growing interest in cellular agriculture as a means to address the public health, environmental, and animal welfare challenges of animal agriculture, the concept of producing seafood from fish cell- and tissue-cultures is emerging as a means to address similar challenges with industrial aquaculture systems and marine capture. Cell-based seafood - as opposed to animal-based seafood - can combine developments in biomedical engineering with modern aquaculture techniques. Biomedical engineering developments such as closed-system bioreactor production of land animal cells create a basis for large scale production of marine animal cells. Aquaculture techniques such as genetic modification and closed system aquaculture have achieved marked gains in production that can pave the way for innovations in cell-based seafood production. Here, we present the current state of innovation relevant to the development of cell-based seafood across multiple species as well as specific opportunities and challenges that exist for advancing this science. The authors find that the physiological properties of fish cell- and tissue- culture may be uniquely suited to cultivation in vitro. These physiological properties, including hypoxia tolerance, high buffering capacity, and low-temperature growth conditions, make marine cell culture an attractive opportunity for scale production of cell-based seafood; perhaps even more so than mammalian and avian cell cultures for cell-based meats. This, coupled with the unique capabilities of crustacean tissue-friendly scaffolding such as chitosan, a common seafood waste product and mushroom derivative, presents great promise for cell-based seafood production via bioreactor cultivation. To become fully realized, cell-based seafood research will require more understanding of fish muscle culture and cultivation; more investigation into serum-free media formulations optimized for fish cell culture; and bioreactor designs tuned to the needs of fish cells for large scale production.

Preprint ARTICLE | doi:10.20944/preprints202305.0407.v1

Developing a Reference Framework for Claim Management Office: A Multi-Method Approach of an International Con-Struction Firm

Ali Mohammad Mirzaee, David Edwards, Wellington Didibhuku Thwala

Subject: Business, Economics And Management, Human Resources And Organizations Keywords: Claim management office (CMO); organisational project management (OPM); built environment; project-based organization (PBO); construction claim

Online: 6 May 2023 (09:45:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1006.v1

PlasmaBlade versus Electrocautery for DIEP Flap Harvesting in Autologous Breast Reconstruction: A Comparative Clinical Outcome Study.

Angela Augustin, Ines Schoberleitner, Sophie-Marie Unterhumer, Johanna Krapf, Thomas Bauer, Dolores Wolfram

Subject: Medicine And Pharmacology, Surgery Keywords: autologous breast reconstruction; clinical outcome; electrosurgery; flap harvesting; PEAK PlasmaBlade

Online: 18 March 2024 (10:24:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1523.v1

Liver Transplantation for Hepatocellular Carcinoma beyond Milan Criteria

Oliver Rohland, Lea Freye, Laura Schwenk, Aladdin Ali-Deeb, Michael Ardelt, Astrid Bauschke, Utz Settmacher, Falk Rauchfuß, Felix Dondorf

Subject: Medicine And Pharmacology, Transplantation Keywords: hepatocellular carcinoma; Milan criteria; living-donor liver transplantation; transplant outcome

Online: 22 January 2024 (10:08:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1346.v1

Robot-Assisted and Manual Cochlear Implantation: An Intra-Individual Study of Speech Recognition

Clémentine MAHEO, Antoine MARIE, Renato TORRES, Jerrid ARCHUTICK, Jean-Christophe LECLERE, Rémi MARIANOWSKI

Subject: Medicine And Pharmacology, Otolaryngology Keywords: electrode array insertion; robot-assisted implantation; hearing outcome; scala translocation

Online: 20 September 2023 (09:57:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1019.v1

Vitamin D Levels as a Marker of Severe SARS-Cov-2 Infection

Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Sofia Nikolakopoulou, Alexandra Konstantinou, Olga Mascha, Evangelos Siarkos, Charilaos Samaras, Panagiotis Athanassiou, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: vitamin D; SARS-CoV-2; outcome; ferritin; d-dimers; fibrinogen

Online: 15 September 2023 (02:40:24 CEST)

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Severe infection from the SARS-CoV-2 virus is associated with various clinical findings, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may lead to death. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is concerned. The aim was to measure 25(OH)D3 levels in patients hospitalized for severe COVID-19 infection, to explore the relationship between 25(OH)D3 and outcome and to investigate the relationship between 25(OH)D3 levels, CRP, ferritin, d-dimers and fibrinogen levels in this cohort. In a cohort of 88 patients hospitalized for severe infection from the SARS-CoV-2 virus and a control group matched for age and sex the levels of 25(OH)D3 were measured. In the same cohort CRP, ferritin, d-dimer and fibrinogen levels were also analyzed. Levels of 25(OH)D3 were 17.36±8.80 ng/ml (mean±SD) as compared with 24.34±10.34 ng/ml, in patients with severe SARS-CoV-2 infection and the control group, respectively, p<0.001 (Student’s t test). The levels of 25(OH)D3 were found to be significantly related to outcome, i.e. survival as opposed to non-survival, as more patients with 25(OH)D3 deficiency (0-10 ng/ml) and insufficiency (10-20 ng/ml) had a fatal outcome as compared with those with vitamin D sufficiency, p<0.001, chi-square test, p<0.001, Fischer’s exact test. Levels of 25(OH)D3 were inversely related to CRP, ferritin, d-dimer and fibrinogen levels, p<0.001, linear regression analysis, beta coefficient of variation, -0.176, -0,160, -0.178, -0.158, respectively. Vitamin D deficiency observed in severe SARS-CoV-2 infection was related to the disease outcome. Increased ferritin levels, and increased thrombotic markers, namely d-dimer and fibrinogen levels were observed in the patients and their concentration was also inversely related to vitamin D. We showed that vitamin D levels were low in hospitalized patients with severe SARS-CoV-2 infection and also inversely related to CRP, ferritin, d-dimer and fibrinogen concentration. It is proposed that vitamin D levels may be an index of severity in the context of SARS-CoV-2 infection.

Preprint ARTICLE | doi:10.20944/preprints202211.0266.v1

In Underweight Women, Insufficient Gestational Weight Gain is Associated with Adverse Obstetric Outcomes

Alizee Montvignier Monnet, Delphine Savoy, Lise Preaubert, Pascale Hoffmann, Cécile Bétry

Subject: Biology And Life Sciences, Food Science And Technology Keywords: pregnancy; newborn; obstetric outcome; birth weight; foetal growth restriction; thinness

Online: 15 November 2022 (01:39:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0108.v1

Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS). Part II

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Adrian M. E. Pilatz, Kurt G. Naber, Florian M. E. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women

Online: 6 September 2021 (17:02:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0285.v1

Wastewater Based Epidemiology, Phylogenetic Analysis and Machine Learning Approach to Describe the Evolution of SARS-CoV-2 in the South-East of Spain

JOSE ANTONIO FEREZ, ENRIC CUEVAS-FERNANDO, MARIA AYALA-SAN NICOLAS, PEDRO J Simón Andreu, ROMAN LOPEZ, Pilar Truchado, Gloria Sánchez, ANA ALLENDE

Subject: Biology And Life Sciences, Virology Keywords: SARS-CoV-2; Epidemiology; Wastewater-based Epidemiology; Phylogenetic Analysis; Machine Learning Approach; Molecular virology

Online: 5 May 2023 (03:31:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0198.v1

Suggestion of an Alternative Approach of Inhalation of Volatile Chemicals from Onion and Garlic for Isolated Patient of Mild Onset Infected Flu: Review and Communication

Huibing Tan, Ganqiu Wu, Xiaotong Li, Wei Hou

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: mild virus-infected flu; home-based treatment; inhalation of volatile chemicals; onion; garlic

Online: 15 February 2020 (14:38:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0282.v1

A Two-step FE Model Updating Approach for System and Damage Identification of Full-Scale Prestressed Bridge Girders

Niloofar Malekghaini, S. Farid Ghahari, Hamed Ebrahimian, Matthew Bowers, Eric Ahlberg, Ertugrul Taciroglu

Subject: Engineering, Civil Engineering Keywords: Modal-based model updating, Bayesian model updating, System identification, Damage identification, Operational health monitoring, I-girder, Bridge, Aging.

Online: 15 December 2022 (10:10:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0219.v1

Mapping Informal Settlements in the Middle East Environment using an Object-Based Machine-Learning Approach

Ahmad Fallatah, Simon Jones, David Mitchell

Subject: Computer Science And Mathematics, Information Systems Keywords: informal settlement indicators; very high resolution (VHR); urbanisation; sustainable development goals; object-based image analysis (OBIA); machine learning (ML); random forest (RF)

Online: 12 September 2018 (12:32:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1221.v1

Long-Term Vocational Outcome at 15 Years from Severe Traumatic and Non Traumatic Brain Injury in Pediatric Age

Sandra Strazzer, Valentina Pastore, Susanna Frigerio, Katia Colombo, Sara Galbiati, Federica Locatelli, Susanna Galbiati

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Brain Injuries; Disorders of consciousness; Childhood; Follow-Up Studies; Vocational Outcome

Online: 16 June 2023 (10:38:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1917.v1

Serum Biomarker Concentrations on Admission in Acute Traumatic Brain Injury: Associations with, TBI Severity, Toxoplasma gondii Infection and Outcome in a Referral Hospital Setting, Cameroon

Franklin Chu Buh, Germaine Sotoing Taiwe, Firas H. Kobeissy, Kevin W. Wang, Andrew I.R. Maas, Basil Kum Meh, Motah Mathieu, Eric Youm, Peter J.A. Hutchinson, Irene Ule Ngole Sumbele

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Serum biomarkers; Traumatic brain injury; CT-scan findings; outcome; Toxoplasma gondii

Online: 26 May 2023 (10:28:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0491.v1

Cross-Sectional Study on Relationships Among FoMO, Social Influence, Positive Outcome Expectancy, Refusal Self-Efficacy and SNS Usage

KUNHUA LEE, Chia-Yu Lin, Jing Tsao, Lien Fang Hsieh

Subject: Social Sciences, Psychology Keywords: FoMO; Social Cognitive Theory; Social Influence; Self-efficacy; Positive Outcome Expectancy

Online: 21 July 2020 (12:57:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0113.v1

Prevalence of Current Smoking and Association with Adverse Outcome in Hospitalized COVID-19 Patients: A Systematic Review and Meta-Analysis

Konstantinos Farsalinos, Konstantinos Poulas, Riccardo Polosa, Anastasia Barbouni, Pasquale Caponnetto, Raymond Niaura

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; COVID-19; inflammation; smoking; nicotine; hospitalization; adverse outcome

Online: 7 May 2020 (08:52:04 CEST)

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Background: The purpose of this study was to examine the prevalence and effects of current smoking on adverse outcomes among hospitalized COVID-19 patients. Methods: We performed a systematic review of the literature (PubMed) for studies published until April 25. Studies were included into the analysis if they satisfied all of the following criteria: 1. To present hospitalized patients with COVID-19. 2. To classify patients into less and more severe disease, irrespective of the severity definition (defined as “adverse ourtcome”). 3. To present data on the smoking status, separately for each severity classification. We identified 18 (from a total of 1398) relevant studies. Pooled current smoking prevalence was compared with the gender-adjusted, population-based expected prevalence by calculating Prevalence Odds Ratio (POR). The association between current, compared to non-current and former, smoking and adverse outcome was examined by calculating Odds Ratio (OR). All analyses were performed using random-effects meta-analysis. Results: Among 6515 patients, 440 of whom were current smokers, the pooled prevalence of current smoking was 6.8% (95%CI: 4.8-9.1%) and the POR was 0.21 (95%CI: 0.16-0.26, P < 0.001). In Chinese studies only, the POR was 0.22 (95%CI: 0.17-0.27, P < 0.001). Current smokers were more likely to have an adverse outcome compared to non-current smokers (OR: 1.53, 95%CI: 1.06-2.20, P = 0.022). However, they were less likely to have an adverse outcome compared to former smokers (OR: 0.42, 95%CI: 0.27-0.74, P = 0.003). Conclusion: An unexpectedly low prevalence of current smoking was observed among hospitalized patients with COVID-19. Hospitalized current smokers had higher odds compared to non-current smokers but lower odds compared to former smokers for an adverse outcome. The possibility that nicotine may have a protective effect in COVID-19 which may be masked by smoking-related toxicity and by the abrupt cessation of nicotine intake when smokers are hospitalized should be explored.

Preprint REVIEW | doi:10.20944/preprints201811.0506.v2

Sleep Disorders as a Mediator Between Socioeconomic Status and Health Outcomes: A Review of Differents Theories

Faustin Armel Etindele Sosso, Dimitrios Papadopoulos

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: circadian rhythm; sleep disorders; socioeconomic status; stress; allostatic load; health outcome

Online: 10 December 2018 (14:18:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0678.v1

Unstructured Text in EMR Improves Prediction of Death after Surgery in Children

Oguz Akbilgic, Ramin Homayouni, Kevin Heinrich, Max Raymond langham, Jr, Robert Lowell Davis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: post-operative death; unstructured data; logistic regression; text mining; surgery outcome

Online: 29 October 2018 (11:46:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0186.v1

The Effect of Pain Relief on Daily Physical Activity: in-Home Objective Physical Activity Assessment in Chronic Low Back Pain Patients after Paravertebral Spinal Block

Tzu Chuan Yen, Jane Mohler, Michael Dohm, Kaveh Laksari, Bijan Najafi, Nima Toosizadeh

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Gait; Pain; Back disorder; Outcome evaluations; Daily activity; Fear of pain

Online: 9 August 2018 (11:26:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0121.v1

Integrated Approach for the Assessment of Strategies for the Decarbonization of Urban Traffic

Dietmar Göhlich, Kai Nagel, Anne Magdalene Syré, Alexander Grahle, Kai Martins-Turner, Ricardo Ewert, Ricardo Miranda Jahn, Dominic Jefferies

Subject: Engineering, Automotive Engineering Keywords: Decarbonization Methodology; Urban Traffic; Agent-Based Transport Simulation; Life Cycle Assessment; Sustainability; Total Cost of Ownership; Charging Concepts; Conceptual Vehicle Design; Battery Electric Vehicles; Vehicle Routing Problem

Online: 6 December 2020 (18:16:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0042.v1

Is it all about Surface Topography? An Intraindividual Clinical Outcome Analysis of Two Different Implant Surfaces in Breast Reconstruction

Ines Schoberleitner, Angela Augustin, Daniel Egle, Christine Brunner, Birgit Amort, Bettina Zelger, Andrea Brunner, Dolores Wolfram

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nipple-sparing mastectomy; prophylactic implant-based breast reconstruction; SMI (silicone mammary implants); SMI surface topography; surface roughness; fibrosis; capsular contracture; aesthetic outcome; intra-individual comparison; titanised mesh implant pocket

Online: 2 December 2022 (07:40:06 CET)

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