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Preprint ARTICLE | doi:10.20944/preprints202402.1016.v1

Emergency and Elective Colorectal Cancer – Relationship between Clinical and Biological Factors, Tumor Topography and Surgical Strategies. A Cohort Study

Ionut Simion Coman, Raluca Cristina Vital, Violeta Elena Coman, Cosmin Burleanu, Mircea Liţescu, Costin George Florea, Daniel Alin Cristian, Gabriel-Petre Gorecki, Petru Adrian Radu, Iancu Emil Pleşea, Anwar Erchid, Valentin Titus Grigorean

Subject: Medicine And Pharmacology, Surgery Keywords: colorectal; cancer; emergency; analysis; outcome

Online: 19 February 2024 (08:07:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1006.v1

PlasmaBlade versus Electrocautery for DIEP Flap Harvesting in Autologous Breast Reconstruction: A Comparative Clinical Outcome Study.

Angela Augustin, Ines Schoberleitner, Sophie-Marie Unterhumer, Johanna Krapf, Thomas Bauer, Dolores Wolfram

Subject: Medicine And Pharmacology, Surgery Keywords: autologous breast reconstruction; clinical outcome; electrosurgery; flap harvesting; PEAK PlasmaBlade

Online: 18 March 2024 (10:24:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1310.v1

Incidence, Risk Factors and Consequences of Acute Kidney Injury in Patients Undergoing Esophageal Cancer Surgery: A Historical Cohort

Ilaria GODI, Paolo Feltracco, Giulia Lorenzoni, Alessio Antonelli, Renato Salvador, Dario Gregori, Ivo Tiberio, Michele Valmasoni

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: postoperative acute kidney injury; esophageal cancer surgery; outcome

Online: 23 February 2024 (10:32:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0382.v1

Everyday Cardiac Surgery in Jehovah‘s Witnesses of Typically Advanced Age: Clinical Outcome and Matched Comparison

Martin Hartrumpf, Ralf-Uwe Kuehnel, Roya Ostovar, Filip Schroeter, Johannes M. Albes

Subject: Medicine And Pharmacology, Surgery Keywords: Jehovah’s Witnesses; cardiac surgery; outcome; transfusion; blood

Online: 7 July 2023 (09:58:24 CEST)

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Background and Objectives: Jehovah's Witnesses (JW) reject the transfusion of blood components based on their religious beliefs even if they are in danger of harm or death. In cardiac surgery, this significantly reduces the margin of safety and leads to ethical conflicts. Informed consent should be carefully documented and the patient's family should be involved. This study aims to compare the postoperative course of JW who underwent major cardiac surgery with a similar population of non-Witnesses (NW). Patients and Methods: Demographic, procedural, and postoperative data of all consecutive JW who underwent cardiac surgery at our institution were obtained from the records. They were compared with a propensity score matched group of NW. Anemic JW were treated with erythropoietin and/or iron as needed. Cardiac surgery was performed by experienced surgeons using median sternotomy and cardiopulmonary bypass. Common blood-sparing techniques were routinely used. Periprocedural morbidity and mortality were statistically evaluated for both groups. Results: 32 JW and 64 NW were part of the matched dataset showing no demographic or procedural differences. EPO was used preoperatively in 34.4% and postoperatively in 15.6% of JW but not in NW. Preoperative hemoglobin levels were similar (JW, 8.09±0.99 mmol/l; NW, 8.18±1.06; p=0.683). JW did not receive any transfusions except for one who revoked, while NW transfusion rates were 2.5±3.1 units for red cells (p<0.001) and 0.3±0.8 for platelets (p=0.018). Postoperative levels differed significantly for hemoglobin (JW, 6.05±1.00 mmol/l; NW, 6.88±0.87; p<0.001), and hematocrit (JW, 0.29±0.04; NW, 0.33±0.04; p<0.001) but not for creatinine. Early mortality was similar (JW, 6.3%; NW, 4.7%; p=0.745). There were more pacemakers and pneumonias in JW, while all other postoperative conditions were not different. Conclusions: Real-world data indicate that Jehovah's Witnesses can safely undergo cardiac surgery provided that patients are preconditioned and treated by experienced surgeons who use blood-saving strategies. Postoperative anemia is observed but does not translate into a worse clinical outcome. This is consistent with other studies.

Preprint ARTICLE | doi:10.20944/preprints201810.0678.v1

Unstructured Text in EMR Improves Prediction of Death after Surgery in Children

Oguz Akbilgic, Ramin Homayouni, Kevin Heinrich, Max Raymond langham, Jr, Robert Lowell Davis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: post-operative death; unstructured data; logistic regression; text mining; surgery outcome

Online: 29 October 2018 (11:46:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0394.v1

Has the Timing of the Surgery a Major Role in Influencing Outcome in Elderly Patients with Acute Subdural Hematomas?

Gianluca Trevisi, Alba Scerrati, Oriela Rustemi, Luca Ricciardi, Tamara Ius, Anna Maria Auricchio, Pasquale De Bonis, Alessio Albanese, Annunziato Mangiola, Rosario Maugeri, Federico Nicolosi, Carmelo Lucio Sturiale

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: acute subdural hematoma; comorbidity; elderly; outcome; surgery; timing of surgery; traumatic brain injury

Online: 23 August 2022 (05:08:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0733.v1

Is Maternal Selenium Status Associated with Pregnancy Outcomes in Physiological and Complicated Pregnancy?

Joanna Pieczyńska, Rafał Sozański, Sylwia Płaczkowska, Halina Grajeta

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: selenium; GPX; pregnancy; pregnancy complications; pregnancy outcome

Online: 10 April 2024 (13:01:47 CEST)

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Selenium is essential for the synthesis and function of various selenoenzymes, such as glutathione peroxidases, selenoprotein P, and thioredoxin reductase, which play an important role in both antioxidant defense and limiting oxidative damage. Associations between serum selenium concentration and obstetric complications as well as pregnancy outcomes has been reported in many studies. The aim of this study was to determine whether the dietary intake of selenium, its concentration in serum and the activity of glutathione peroxidase in subsequent trimesters of pregnancy affect the birth condition of newborns assessed on the basis of the Apgar score in the 1st and 5th minute of life, birth weight, body length and head and chest circumference in physiological and complicated pregnancy course. Twenty-seven pregnant women at a mean age 29.6 ± 4.8 years from the Lower Silesia region of Poland were recruited to the study, 55% of studied group had pregnancy complications. The mean reported Se intake and serum selenium content for Polish pregnant women was in the first trimester – 56.53 μg/day and 43.75 μg/l, the second trimester – 61.79 μg/day and 41.77 μg/l and the third trimester – 58.37 μg/day and 42.13 μg/l, respectively. In the subgroup of pregnant women with a physiological pregnancy course, a weak, although statistically significant, positive correlation was found in the first trimester between Se intake and the length (R=0.48, p=0.019) and birth weight of newborns (R=0.472, p=0.022), and in the second trimester with the APGAR score at 1 (R=0.680, p=0.005) and 5 minutes (R=0.55, p=0.033), as well as in the third trimester with th APGAR score at 1 minut (R=0.658, p=0.019). The GPX value had a strong positive correlation with the APGAR score at 1 min. (R=0.650, p=0.008) in the second trimester and with the birth weight of the newborns (R=0.598, p=0.039) in the third trimester. There was no correlation between newborns' birth measurements and serum selenium concentration. In the subgroup of pregnant women with pregnancy complications, a strong, statistically significant, negative correlation was found between Se intake in the second trimester and gestational age (R=-0.618, p=0.032), and in the third trimester, a positive correlation between Se concentration in serum and head circumference (R=0.587, p=0.021). The obtained results indicate that there is a relationship between the maternal selenium status during pregnancy, both in terms of the intake of this element, its serum concentration as well as the glutathione peroxidase activity, and the anthropometric parameters of the newborn, such as birth weight, length and APGAR score, especially in the group with physiological course of pregnancy, but when pregnancy complications occur, these relationships lose their importance.

Preprint ARTICLE | doi:10.20944/preprints201701.0013.v1

Persons with Rheumatoid Arthritis Challenge the Relevance of the Health Assessment Questionnaire: A Qualitative Study of Patient Perception

David Ebbevi, Anna Essén, Helena Hvitfeldt Forsberg

Subject: Public Health And Healthcare, Nursing Keywords: Rheumatoid Arthritis; thematic analysis; Outcomes assessment; Qualitative Research; Patient reported outcome measures

Online: 3 January 2017 (11:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0130.v1

Effects of Postoperative Wound Infiltration Analgesia with Bupivacaine or Diclofenac on Long-Term Outcomes in Patients After Breast Cancer Surgery

Josipa Glavas Tahtler, Dajana Djapic, Marina Neferanovic, Jelena Miletic, Marta Milosevic, Kristina Kralik, Nenad Neskovic, Ilijan Tomas, Dora Mesaric, Ksenija Marjanovic, Jasmina Rajc, Zelimir Orkic, Ana Cicvaric, Slavica Kvolik

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Breast Cancer; Acute Postoperative Pain; Postoperative analgesia; Patient-Controlled Analgesia; Levobupivacaine; Diclofenac; Hand Grip Strength; Quality of life; Treatment Outcome; Long term survival.

Online: 2 August 2023 (04:37:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0087.v1

Difference between Serum BNP Admission Level and that Detected at Discharge in Patients with ADHF Predicts Six-Month Mortality in a More Reliable Manner with Respect to Isolated BNP Determination Taken on Admission

Renato De Vecchis, Carmelina Ariano, Cesare Baldi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: natriuretic peptides; heart failure; congestion; outcome

Online: 9 August 2016 (11:33:03 CEST)

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Background According to some authors, a single isolated measurement of serum BNP executed on hospital admission would not be a sufficiently accurate method to predict the outcome of patients with ADHF. Aims For verifying this assumption, a retrospective study was conducted on patients hospitalized for ADHF. Our main objective was to ascertain whether there was any difference in midterm mortality among patients with rising BNP at discharge as compared to those with decreasing BNP at discharge. Methods Medical records were examined so as to make a partition of the ADHF patient population into two groups, the former characterized by a rise in BNP during hospitalization, and the latter exhibiting a decrease in BNP in the measurement taken at hospital discharge. Results 177 patients were enrolled in a retrospective study. Among them, 53 patients (29.94%) had increased BNPs at the time of discharge, whereas 124 (70.06%) showed decreases in serum BNP during their hospital stay. The group with patients who exhibited BNP increases at the time of discharge had higher degree of congestion evident in the higher frequency of persistent jugular venous distention and persistent orthopnea at discharge. Moreover, patients with increased BNP at the time of discharge had a lower reduction in inferior vena cava maximum diameter [1.58 ± 2.2 mm vs. 6.32 ± 1.82 mm; p (one-way ANOVA)=0.001]. In contrast, there was no significant difference in weight loss when patients with increased BNP at discharge were compared to those with no such increase. A total of 14 patients (7.9%) died during the six-month follow-up period. Cox proportional hazard analysis revealed that BNP increase at the time of discharge was an independent predictor of six-month all-cause mortality after adjustment for age, sodium at discharge, creatinine at discharge and New York Heart Association (NYHA) class at discharge (hazard ratio 34.49; 95% confidence intervals: 4.55–261.06; P =0.001). Conclusions Among patients with history of ADHF, more elevated BNP levels at the time of discharge from the hospital compared to those detected at admission identify a patient subset with higher grade of congestion and higher six-month mortality.

Preprint ARTICLE | doi:10.20944/preprints202304.0001.v1

The Pattern of Changes in Body Mass Index before and during Pregnancy: The Maternal and Neonatal Outcome

Gamal Sayed, Husam Salama, Lina Abdullah, Sawsan Al-Obaidly, Mai Al-Qubaisi, Ashraf Mansour

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: BMI; obesity; pregnancy; maternal outcome; neonatal outcome; Qatari women

Online: 3 April 2023 (02:07:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0067.v1

The Impact of First Timing of Antibiotics for Community Acquired Pneumonia in Emergency Department

Yiwu Zhou, Casey M. Clements, Man Li, Yanqi He, Rong Yao

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Pneumonia; Timing; Antibiotics; Outcome

Online: 3 September 2020 (09:29:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0838.v1

Reference Values for the German Version of the Quality of Life after Brain Injury in Children and Adolescents (QOLIBRI-KID/ADO) from a General Population Sample

Leonie Krol, York Hagmayer, Nicole von Steinbuechel, Katrin Cunitz, Anna Buchheim, Inga K. Koerte, Marina Zeldovich

Subject: Social Sciences, Psychology Keywords: reference values; general population; patient-reported outcome measure (PROM); health-related quality of life; children and adolescents; traumatic brain injury

Online: 15 February 2024 (10:02:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1582.v1

A Comprehensive Review on the Role of Resting State Functional Magnetic Resonance Imaging in Predicting Post-stroke Motor and Sensory Outcome

Foteini Christidi, Ilias Orgianelis, Ermis Merkouris, Christos Koutsokostas, Dimitrios Tsiptsios, Efstratios Karavasilis, Evlampia A. Psatha, Anna Tsiakiri, Aspasia Serdari, Nikolaos Aggelousis, Konstantinos Vadikolias

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: functional magnetic resonance imaging; resting-state functional connectivity; stroke; motor outcome; sensory outcome; biomarkers

Online: 20 December 2023 (21:49:18 CET)

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Working Paper ARTICLE

Prospective Systematic Data Collection in Early COVID-19 Patients: A Protocol for Individualized Treatment and Outcomes Research

Flávio Dantas

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Treatment outcome; Data Collection; Pharmaceutical Preparations; Outcome Assessment; Health Care

Online: 4 September 2020 (10:12:02 CEST)

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Human infection caused by the SARS-CoV-2 virus, called COVID-19, is a new pandemic with devastating effects worldwide. Science seeks the rational and systematic explanation of phenomena. In pandemics, decisions on prevention and treatment of people should be consistently taken, supported by scientific knowledge and ethical principles to produce more good than harm. At first, prospective observational studies to systematically collect patient data, correlating protective or therapeutic interventions with outcomes to assess effectiveness and safety, should be prioritized as the most appropriate type of study. The proposed protocol in this article aims to provide doctors with information on the reduction of harm in early COVID-19 patients by applying individualized interventionist or expectant therapeutic strategies, respecting the autonomy and preferences of physicians and patients in clinical decision-making. The evaluation of the clinical status, besides laboratory confirmation of COVID-19, comprises an individualized symptom score for each patient, a global self-perception scale of the severity of the disease, a clinical progression scale developed by the WHO for clinical studies in COVID-19 and, at the first consultation, doctors´ overall impression on the clinical prognosis. The analysis of anonymized data should preferably use descriptive and inferential statistical resources. The case report form is available for free use in the protocol, along with examples of patient informed consent forms for the prescription of off-label medications and authorization to use the data. Their results may be useful to indicate interventions that are candidates for efficacy trials, in randomized controlled trials, with a higher chance of success. It respects the autonomy and preferences of doctors and patients to decide the best options for treatment in uncertain situations. It also allows the gathering of useful information for future more rigorous clinical trials, trying to link science, ethics, and personal clinical experience.

Preprint ARTICLE | doi:10.20944/preprints202310.1983.v1

Spontaneous Cultural Conversion Rate of Mycobacterium avium Complex Pulmonary Disease Based on Baces Severity

Bo-Guen Kim, Jin Young Yu, Byung Woo Jhun

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Mycobacterium avium complex; outcome; treatment; severity

Online: 31 October 2023 (09:07:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1876.v1

The Clinical Implications of Serum Carbohydrate Antigen 19-9 Levels in Patients with Nontuberculous Mycobacteria Pulmonary Disease

Daegeun Lee, Byung Woo Jhun

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: nontuberculous mycobacteria; carbohydrate antigen; outcome; treatment

Online: 30 October 2023 (12:20:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1197.v1

Long-Term Outcomes in Patients Undergoing Thoracic Endovascular Aortic Repair. Single Center Experience

Aleksander Dokollari, Serge Sicouri, Gianluca Torregrossa, Roberto Rodriguez, Robert Meisner, Henry Hirsch, Vincent DiGiovanni, Alexander Uribe, Beatrice Bacchi, Francesso Cabrucci, Bruno Chiarello, Basel Ramlawi, Massimo Bonacchi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: TEVAR; long-term outcome; MACCE

Online: 16 August 2023 (09:17:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0717.v1

Molecular Characterization of Ovarian Yolk Sac Tumor (OYST)

Khalil Hodroj, Aleksandra Stevovic, Valery Attignon, Domenico Ferraioli, Pierre Meeus, Sabrina Croce, Nicolas Chopin, Lea Rossi, Anne Floquet, Christine Rousset-Jablonski, Olivier Tredan, Frédéric Guyon, Isabelle Treilleux, Corinne Rannou, Marie Morfouace, Isabelle Ray-Coquard

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: OYST; molecular characteristics; targetable mutation; patients’ outcome

Online: 30 November 2020 (11:06:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0261.v1

Unbiased Approach for the Identification of Molecular Mechanisms Sensitive to Chemical Exposures

Alexander Suvorov, Victoria Salemme, Joseph McGaunn, Anthony Poluyanoff, Menna Teffera, Saira Amir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: adverse outcome pathway; toxicity pathway; computational toxicology

Online: 21 June 2020 (11:10:34 CEST)

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Background: Targeted methods that dominated toxicological research until recently did not allow for screening of all molecular changes involved in toxic response. Therefore, it is difficult to infer if all major mechanisms of toxicity have already been discovered, or if some of them are still overlooked. Objectives: To identify molecular mechanisms sensitive to chemical exposures in an unbiased manner. Methods: We used data on 641,516 unique chemical-gene interactions from the Comparative Toxicogenomic Database. Only data from high-throughput gene expression experiments with human, rat or mouse cells/tissues were extracted. The total number of chemical-gene interactions was calculated for every gene, and used as a measure of gene sensitivity to chemical exposures. These values were further used in enrichment analyses to identify molecular mechanisms sensitive to chemical exposures. Results: Remarkably, use of different input subsets with non-overlapping lists of chemical compounds identified largely the same genes and molecular pathways as most sensitive to chemical exposures, indicative of an unbiased nature of our analysis. One of the most important findings of this study is that almost every known molecular mechanism may be affected by chemical exposures. Predictably, xenobiotic metabolism pathways and mechanisms of cellular response to stress and damage were among the most sensitive. Additionally, our analysis identified a range of highly sensitive molecular pathways, which are not widely recognized by modern toxicology as major targets of toxicants, including lipid metabolism pathways, longevity regulation cascade and cytokine mediated signaling. Discussion: Molecular mechanisms identified as the most sensitive to chemical exposures are relevant for significant public health problems, such as aging, cancer, metabolic and autoimmune disease. Thus, public health system will likely benefit from future research focus on these sensitive molecular mechanisms. Additionally, approach used in this study may guide identification of priority adverse outcome pathways (AOP) for in-vitro and in-silico toxicity testing methods.

Preprint ARTICLE | doi:10.20944/preprints202107.0680.v1

Characteristics of Surgical Necrotizing Enterocolitis: Is It Different from Medical Necrotizing Enterocolitis? A Single-Center Retrospective Study

Ara Cho, Dayoung Ko, JoongKee Youn, Hee-Beom Yang, Hyun-Young Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: NEC; Surgical; Medical; Risk factor; Outcome; Neonate

Online: 30 July 2021 (09:11:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1554.v1

Computation of The Mann-Whitney Effect under Parametric Survival Copula Models

Kosuke Nakazono, Yu-Cheng Lin, Gen-Yih Liao, Ryuji Uozumi, Takeshi Emura

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: censoring; copula; Hand’s paradox; potential outcome; Mann-Whitney effect; stress-strength model; two-sample comparison; survival analysis; survival function; treatment effect

Online: 26 March 2024 (09:41:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0092.v1

Neutrophil Dynamics in Acute Coronary Syndrome

Patrick Maréchal, Julien Tridetti, Mai-Linh Nguyen, Odile Wéra, Zheshen Jiang, Maxime Gustin, Anne-Françoise Donneau, Cécile Oury, Patrizio Lancellotti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Acute coronary syndrome; inflammation; neutrophil; outcome

Online: 7 April 2020 (11:18:03 CEST)

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Working Paper ARTICLE

Patterns, Management and Outcome of Traumatic Femur Fracture: Exploring the Experience of the Only Level 1 Trauma Center in Qatar

Syed Imran Ghouri, Mohammad Asim, Fuad Mustafa, Ahad Kanbar, Mohamed Ellabib, Hisham Al Jogol, Mohammed Muneer, Nuri Abdurraheim, Atirek Pratap Goel, Husham Abdelrahman, Hassan Al-Thani, Ayman El-Menyar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: femur fracture; orthopedic; trauma; management and outcome; Qatar

Online: 15 April 2021 (12:11:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0025.v1

A Cross sectional Observational Study of Safety and Protective Effects of Maternal Influenza Vaccination on Pregnancy and Birth Outcomes in pregnant women from Pune, India

Hanif Shaikh, Pranesha Koli, Anil Pardeshi, Vaishali Undale, Mahesh Asalkar, Sushant Sahatrabuddhe, Anand Kawade, Chandrashekhar Upasani

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Maternal immunization; influenza vaccination; pregnant women; pregnancy outcome

Online: 3 April 2023 (11:00:36 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202005.0253.v1

Outcomes Comparison of SpCas9- and LbCas12a-mediated DNA Editing in Zebrafish Embryos

Darya Meshalkina, Aleksei Glushchenko, Elana Kysil, Igor Mizgirev, Andrej Frolov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cas9; Cas12a; Cpf1; zebrafish; gene knockout; repair outcome

Online: 15 May 2020 (10:16:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1518.v1

Comparative Analysis of Maternal and Neonatal Outcomes between Elective and Emergency Cesarean Section at a Single Tertiary Hospital

Nihal Al Riyami, Shurooq Al Shereiqi, Silja Pillai

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Cesarean section; risk factors; pregnancy complications; pregnancy outcome

Online: 22 May 2023 (11:21:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1946.v1

Direct Comparison of Elastic Stable Intramedullary Nailing and External Fixation for Managing Diaphyseal Femoral Fractures in Children: A Retrospective Analysis

Norbert Thomas, Ulrike Wittig, Thomas Boehm, Maximilian Burtscher, Harald Binder, Micha Komjati, Stephan Payr, Kambiz Sarahrudi, Thomas Manfred Tiefenboeck

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: children; diaphyseal femur fractures; external fixation; ESIN; outcome

Online: 28 September 2023 (09:39:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1454.v1

Effects of Vasopressin Receptor Agonists During the Resuscitation of Hemorrhagic Shock: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies

Eleni Laou, Nikolaos Papagiannakis, Androniki Papadopoulou, Theodora Choratta, Minas Sakellakis, Mariachiara Ippolito, Ioannis Pantazopoulos, Andrea Cortegiani, Athanasios Chalkias

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: vasopressin; vasopressin receptor agonist; hemorrhagic shock; resuscitation; hemodynamics; outcome

Online: 20 June 2023 (14:57:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1569.v1

Cross-cultural adaptation, reliability, and validity of the Polish version of the Neck Outcome Score

Nicola Dyrek, Łukasz Pulik, Aleksandra Piwowarczyk, Wiktoria Skała, Nina Grabowska, Paweł Łęgosz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Cervical Pain; Patient-Reported Outcome Measure; Validation Study; Poland

Online: 22 August 2023 (11:33:55 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202101.0065.v1

Advanced Adverse Outcome Pathways Potentially Bridging the Pathogenesis of COVID-19

Youngjun kim, Chang Gyun Park, Sang Rak Lim, Indong Jun, Yong Oh Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; Angiotensin Converting Enzyme 2 (ACE2); Adverse outcome pathway(AOP); Molecular initiation Event (MIE); Key event (KE); Adverse Outcome (AO)

Online: 4 January 2021 (16:37:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0021.v1

Pioglitazone is Associated with Lower Major Adverse Cardiovascular and Cerebrovascular Events than DPP4-Inhibitors in Diabetic Patients with End-Stage Renal Disease: A Taiwan Nationwide Cohort Study, 2006-2016

Min-Hao Lin, Huang-Yu Yang, Chieh-Li Yen, Chao-Yi Wu, Chang-Chyi Jenq, George Kuo, Wei-Sheng Peng, Jia-Rou Liu, Ya-Chung Tian, Chih-Wei Yang, Gerard Anderson, Lai-Chu See

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pioglitazone; DPP4-inhibitor; ESRD; Cardiovascular outcome; Mortality

Online: 1 October 2020 (15:41:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2082.v1

Characteristics Associated with Major Complications and Refractory Course in Patients with Osteomyelitis of the Jaw: Clinical, Radiological, and Bacteriological Features of 54 Patients

MATHILDE FENELON, Steven Gernandt, Romain Aymon, PAOLO SCOLOZZI

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Bone; Osteomyelitis; Decortication; Treatment Outcome; Oral and Maxillofacial Surgery

Online: 30 May 2023 (08:16:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0809.v1

Prognostic Significance of Physiological and Biochemical Parameters in Colic-Afflicted Equine

Indrė Mickevičienė, Donata Mikalauskienė, Dovilė Dambrauskaitė, Zoja Miknienė

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: colic syndrome; equine; prognostic; survival; outcome; physiological; parameters; biochemical

Online: 14 November 2023 (05:34:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0390.v1

Prospective Evaluation of the Weekend Effect on Mortality Outcomes in Aortic Dissection

Cosmin Banceu, Marius Harpa, Klara Brinzaniuc, Nicolae Neagu, Dan Alexandru Szabo, Diana Banceu, Marvin Oprean, Hussam Al Husseim, Daiana Cristutiu, Alexandru Antoniu Stan, Marius Neamtu Halic, Horatiu Suciu

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aortic dissection outcome; weekend effect; aortic dissection risk factor

Online: 22 March 2023 (03:29:20 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202101.0573.v1

Systematic Organization of COVID-19 Data Supported by the Adverse Outcome Pathway Framework

Penny Nymark, Magdalini Sachana, Sofia Batista-Leite, Jukka Sund, Catharine E Krebs, Kristie Sullivan, Stephen Edwards, Laura Viviani, Kate Willett, Brigitte Landesmann, Clemens Wittwehr

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Adverse Outcome Pathways; COVID-19; mechanisms; systematic organization; interdisciplinary

Online: 27 January 2021 (17:01:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0916.v1

Diagnostic and Prognostic Roles of Procalcitonin and Other Markers in Pneumonia: A Literature Update

Sedat OZBAY, Mustafa AYAN, Ozgur Karcioglu

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: pneumonia; bacteremia; sepsis; procalcitonin; diagnosis; biomarker; outcome; antibiotic stewardship

Online: 25 April 2023 (10:00:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0167.v1

Predictive Utility of Changes in Optic Nerve Sheath Diameter after Cardiac Arrest for Neurologic Outcomes

Heekyung Lee, Joonkee Lee, Hyungoo Shin, Changsun Kim, Hyuk Joong Choi, Bo Seung Kang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Heart arrest; optic nerve sheath diameter; Patient outcome assessment

Online: 10 May 2021 (10:51:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0223.v1

Characteristics of Nephroblastoma / Nephroblastomatosis in Children With a Clinically Reported Underlying Malformation or Cancer Predisposition Syndrome

Nils Welter, Angelo Wagner, Rhoikos Furtwängler, Patrick Melchior, Leo Kager, Christian Vokuhl, Jens-Peter Schenk, Clemens Magnus Meier, Stefan Siemer, Manfred Gessler, Norbert Graf

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nephroblastoma; clinical malformations; cancer predisposition syndromes; tumor surveillance; outcome

Online: 10 August 2021 (09:55:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0269.v1

Prevalence, Pattern and Outcome of Pediatric Lassa Fever Disease (LFD) in a Tertiary Hospital, Southeast Nigeria

Maria-Lauretta Orji, Nnamdi Onyire, Uche Unigwe, Nnennaya Ajayi, Demian Nwidi, Elizabeth Odey, Joseph Agboeze, Chiedozie Ojide, Fortune Ujunwa, Emeka Onwe, Robinson Onoh, Precious Madume

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: case fatality; Lassa virus; pattern; positivity rate; outcome; ribavirin

Online: 16 May 2020 (16:41:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0316.v1

Type of ANCA may be Superior to Clinical Phenotype in Distinguishing Different Clinical Entities in ANCA-associated Vasculitis

Afroditi Maria Konstantouli, Georgios Lioulios, Asimina Fylaktou, Maria Stangou

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ANCA-associated vasculitis; Proteinase 3; Myeloperoxidase; Clinical Phenotype; Outcome

Online: 17 August 2022 (09:58:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0124.v1

The Impact of Body-Mass-Index on Functional Outcomes and Bleeding Volumes in Patients Suffering Non-Traumatic Intracerebral Haemorrhage

Stefan Wanderer, Attill Saemann, Basil Grüter, Sivani Sivanrupan, Julian Louis Muff, Donato D'Alonzo, Miriam Weiss, Angelo Tortora, Christian Musahl, Gerrit Schubert, Serge Marbacher, Lukas Andereggen

Subject: Public Health And Healthcare, Other Keywords: Body-mass-index; intracerebral haemorrhage; bleeding volume; functional outcome

Online: 3 October 2023 (10:35:39 CEST)

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The association between obesity and clinical as well as radiological outcomes in patients suffering non-traumatic intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective effect regarding in-hospital mortality. This study evaluates the impact of body mass index (BMI) on functional long-term outcome and bleeding volume in patients with non-traumatic ICH. A retrospective cohort study including all consecutive patients with spontaneous ICH treated at a tertiary referral centre between December 2017 and June 2021, aged 80 years or younger (n = 218), were included. Patients were dichotomized into overweight (OW, BMI ≥ 25 kg/m2) and normal weight (NW, BMI < 25 kg/m2). Functional outcomes were assessed by the modified Rankin scale (mRS), extended Glasgow Outcome Scale (GOS-E) and the National Institutes of Health Stroke Scale score (NIHSS) at 1, 3, 6 and 12-months follow-up. Bleeding volumes were calculated as ABC/2. Univariate and multivariate analysis were performed to assess clinical predictors of favourable outcome in the long-term. Of 218 patients (66.04 ± 15.18 years) suffering non-traumatic ICH, 115 (52.75%) were OW (29.72 ± 3.82). Female sex (p = 0.1), NIHSS (p = 0.69), cardiovascular risk factors (p = 0.55), ICH volume (p = 0.19), and presence of anticoagulation (p = 0.67) did not significantly differ between the OW and NW cohort. At discharge, functional outcome did not significantly differ between both cohorts (NW, mRS 3.92 ± 2.54 vs. OW, mRS 3.21 ± 2.43, (p = 0.28)). Multivariate analysis revealed that haemorrhage volume (p = 0.01) was the only robust risk factor to predict functional outcome after 1 year. Our data suggests that in ICH patients, neither obesity nor patient’s age are negative predictors for functional outcome in the long-term. Instead, bleeding volume is a robust risk factor predicting poor functional status after ICH. Therefore, prospective randomized trials analysing this coherence are highly warranted.

Preprint ARTICLE | doi:10.20944/preprints202109.0108.v1

Clinical Validation of the Greek Version of the Acute Cystitis Symptom Score (ACSS). Part II

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Adrian M. E. Pilatz, Kurt G. Naber, Florian M. E. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; cystitis; patient-reported outcome; questionnaire; women

Online: 6 September 2021 (17:02:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0392.v1

Comparison of Renin–Angiotensin–Aldosterone System Inhibitors with Other Antihypertensives in Association with Coronavirus Disease-19 Clinical Outcomes: Systematic Review and Meta-Analysis

Yihienew M. Bezabih, Alemayehu Bezabih, Endalkachew Admassie, Gregory M. Peterson, Woldesellassie Bezabhe

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: RAAS inhibitors; COVID-19; coronavirus; angiotensin; clinical outcome; antihypertensive

Online: 24 May 2020 (17:48:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0057.v1

Learning Ethical, Environmental and Professional Responsibil-Ity at Universitat Politècnica de València. Where Are We?

Ester Gimenez-Carbo, M. Esther Gómez-Martín, Ernesto Fenollosa, Marta Cabedo-Fabrés, Eloína Coll-Aliaga, Ignacio Andrés-Doménech, María-Teresa Sebastiá-Frasquet, María Vargas, Nuria Pascual-Seva, Alicia LLorca-Ponce, J. Felix Lozano, Antonio Martí-Campoy

Subject: Engineering, Automotive Engineering Keywords: cross-curricular learning outcome; ethical responsibility; environmental responsibility

Online: 2 July 2021 (14:13:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1019.v1

Vitamin D Levels as a Marker of Severe SARS-Cov-2 Infection

Lambros Athanassiou, Ifigenia Kostoglou-Athanassiou, Sofia Nikolakopoulou, Alexandra Konstantinou, Olga Mascha, Evangelos Siarkos, Charilaos Samaras, Panagiotis Athanassiou, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: vitamin D; SARS-CoV-2; outcome; ferritin; d-dimers; fibrinogen

Online: 15 September 2023 (02:40:24 CEST)

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Severe infection from the SARS-CoV-2 virus is associated with various clinical findings, including hematological manifestations. Thrombotic events or a tendency to develop thrombotic events also characterize severe COVID-19 disease and may lead to death. Vitamin D is known to have immunomodulating properties and to enhance the body defense system against invading pathogens and to have immunostimulatory properties as far as the innate immune response is concerned. The aim was to measure 25(OH)D3 levels in patients hospitalized for severe COVID-19 infection, to explore the relationship between 25(OH)D3 and outcome and to investigate the relationship between 25(OH)D3 levels, CRP, ferritin, d-dimers and fibrinogen levels in this cohort. In a cohort of 88 patients hospitalized for severe infection from the SARS-CoV-2 virus and a control group matched for age and sex the levels of 25(OH)D3 were measured. In the same cohort CRP, ferritin, d-dimer and fibrinogen levels were also analyzed. Levels of 25(OH)D3 were 17.36±8.80 ng/ml (mean±SD) as compared with 24.34±10.34 ng/ml, in patients with severe SARS-CoV-2 infection and the control group, respectively, p<0.001 (Student’s t test). The levels of 25(OH)D3 were found to be significantly related to outcome, i.e. survival as opposed to non-survival, as more patients with 25(OH)D3 deficiency (0-10 ng/ml) and insufficiency (10-20 ng/ml) had a fatal outcome as compared with those with vitamin D sufficiency, p<0.001, chi-square test, p<0.001, Fischer’s exact test. Levels of 25(OH)D3 were inversely related to CRP, ferritin, d-dimer and fibrinogen levels, p<0.001, linear regression analysis, beta coefficient of variation, -0.176, -0,160, -0.178, -0.158, respectively. Vitamin D deficiency observed in severe SARS-CoV-2 infection was related to the disease outcome. Increased ferritin levels, and increased thrombotic markers, namely d-dimer and fibrinogen levels were observed in the patients and their concentration was also inversely related to vitamin D. We showed that vitamin D levels were low in hospitalized patients with severe SARS-CoV-2 infection and also inversely related to CRP, ferritin, d-dimer and fibrinogen concentration. It is proposed that vitamin D levels may be an index of severity in the context of SARS-CoV-2 infection.

Preprint ARTICLE | doi:10.20944/preprints202309.1346.v1

Robot-Assisted and Manual Cochlear Implantation: An Intra-Individual Study of Speech Recognition

Clémentine MAHEO, Antoine MARIE, Renato TORRES, Jerrid ARCHUTICK, Jean-Christophe LECLERE, Rémi MARIANOWSKI

Subject: Medicine And Pharmacology, Otolaryngology Keywords: electrode array insertion; robot-assisted implantation; hearing outcome; scala translocation

Online: 20 September 2023 (09:57:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2045.v1

Evolving a Model for Cochlear Implant Outcome

Ulrich Hoppe, Anne Hast, Joachim Hornung, Thomas Hocke

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Word Recognition; CI Outcome; prediction; generalised linear model; adults

Online: 31 July 2023 (11:47:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201909.0081.v1

Prenatal Mercury Exposure and Postnatal Outcome: A Case Series in Bogotá, Colombia

Nelsy Niño-Rodríguez, María Margarita Manrique Andrade, Diana María Perez-Castiblanco, Cesar Alejandro Geney, Diana Patricia Castro Aguilar, Adriana Ruíz, Angélica María Téllez, Luis Jorge Hernández-Florez, Oscar Andrés Bociga, Helena Groot de Restrepo, Diana María Narváez

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: mercury; prenatal exposure; postnatal outcome; environmental health; epidemiological monitoring

Online: 7 September 2019 (01:06:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0089.v1

‘All I Ever Want to Eat is Pizza and Pasta’: Italian Food Temptations Associated with Adverse Perinatal Outcomes

Stefania Triunfo, Roberta Mayer, Michelangela Danza, Antonio Lanzone

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Fook intake; pizza; pasta; vegetables; pregnancy; adverse perinatal outcome

Online: 8 April 2019 (11:35:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0506.v2

Sleep Disorders as a Mediator Between Socioeconomic Status and Health Outcomes: A Review of Differents Theories

Faustin Armel Etindele Sosso, Dimitrios Papadopoulos

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: circadian rhythm; sleep disorders; socioeconomic status; stress; allostatic load; health outcome

Online: 10 December 2018 (14:18:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0113.v1

Prevalence of Current Smoking and Association with Adverse Outcome in Hospitalized COVID-19 Patients: A Systematic Review and Meta-Analysis

Konstantinos Farsalinos, Konstantinos Poulas, Riccardo Polosa, Anastasia Barbouni, Pasquale Caponnetto, Raymond Niaura

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: SARS-CoV-2; COVID-19; inflammation; smoking; nicotine; hospitalization; adverse outcome

Online: 7 May 2020 (08:52:04 CEST)

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Background: The purpose of this study was to examine the prevalence and effects of current smoking on adverse outcomes among hospitalized COVID-19 patients. Methods: We performed a systematic review of the literature (PubMed) for studies published until April 25. Studies were included into the analysis if they satisfied all of the following criteria: 1. To present hospitalized patients with COVID-19. 2. To classify patients into less and more severe disease, irrespective of the severity definition (defined as “adverse ourtcome”). 3. To present data on the smoking status, separately for each severity classification. We identified 18 (from a total of 1398) relevant studies. Pooled current smoking prevalence was compared with the gender-adjusted, population-based expected prevalence by calculating Prevalence Odds Ratio (POR). The association between current, compared to non-current and former, smoking and adverse outcome was examined by calculating Odds Ratio (OR). All analyses were performed using random-effects meta-analysis. Results: Among 6515 patients, 440 of whom were current smokers, the pooled prevalence of current smoking was 6.8% (95%CI: 4.8-9.1%) and the POR was 0.21 (95%CI: 0.16-0.26, P < 0.001). In Chinese studies only, the POR was 0.22 (95%CI: 0.17-0.27, P < 0.001). Current smokers were more likely to have an adverse outcome compared to non-current smokers (OR: 1.53, 95%CI: 1.06-2.20, P = 0.022). However, they were less likely to have an adverse outcome compared to former smokers (OR: 0.42, 95%CI: 0.27-0.74, P = 0.003). Conclusion: An unexpectedly low prevalence of current smoking was observed among hospitalized patients with COVID-19. Hospitalized current smokers had higher odds compared to non-current smokers but lower odds compared to former smokers for an adverse outcome. The possibility that nicotine may have a protective effect in COVID-19 which may be masked by smoking-related toxicity and by the abrupt cessation of nicotine intake when smokers are hospitalized should be explored.

Preprint ARTICLE | doi:10.20944/preprints201808.0186.v1

The Effect of Pain Relief on Daily Physical Activity: in-Home Objective Physical Activity Assessment in Chronic Low Back Pain Patients after Paravertebral Spinal Block

Tzu Chuan Yen, Jane Mohler, Michael Dohm, Kaveh Laksari, Bijan Najafi, Nima Toosizadeh

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Gait; Pain; Back disorder; Outcome evaluations; Daily activity; Fear of pain

Online: 9 August 2018 (11:26:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0162.v1

Outcome at 7 Years of Age of Former Very Preterm Neonates Treated with Repeated Surfactant for Prolonged Respiratory Distress in the Neonatal Period

Jean-Michel Hascoet, Hélène Deforge, Silvia Demoulin, Jean-Charles Picaud, Veronique Zupan, Isabelle Ligi, Francois Moreau, Aurelie Labarre, Patrick Daoud, Laurent Storme, Claude Bonabel, Isabelle Hamon

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: extreme prematurity; surfactant; outcome; children; longitudinal study; pulmonary function testing; neurodevelopment; asthma

Online: 5 September 2023 (05:08:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0662.v1

Seven Years Maintenance Cost of Implant-Retained Overdentures on Ball Versus Locator ® Abutments.

Jan D'haese, Carine Matthys, Hamed Sahak, Jos Besseler, Hugo De Bruyn

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: maintenance cost; patient related outcome measurements; quality of life; mandibular overdentures; edentulism

Online: 26 November 2020 (10:40:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1523.v1

Liver Transplantation for Hepatocellular Carcinoma beyond Milan Criteria

Oliver Rohland, Lea Freye, Laura Schwenk, Aladdin Ali-Deeb, Michael Ardelt, Astrid Bauschke, Utz Settmacher, Falk Rauchfuß, Felix Dondorf

Subject: Medicine And Pharmacology, Transplantation Keywords: hepatocellular carcinoma; Milan criteria; living-donor liver transplantation; transplant outcome

Online: 22 January 2024 (10:08:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0266.v1

In Underweight Women, Insufficient Gestational Weight Gain is Associated with Adverse Obstetric Outcomes

Alizee Montvignier Monnet, Delphine Savoy, Lise Preaubert, Pascale Hoffmann, Cécile Bétry

Subject: Biology And Life Sciences, Food Science And Technology Keywords: pregnancy; newborn; obstetric outcome; birth weight; foetal growth restriction; thinness

Online: 15 November 2022 (01:39:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0512.v1

Real-World Effectiveness of Meropenem: Results of an Observational Study in 84 Colombian Patients

Santiago Garnica-Velandia, Aristizábal-Ruiz Luz Adriana, Carlos Arturo Alvarez-Moreno

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: antimicrobials; meropenem; generic drug; real-life studies; product surveillance, postmarketing; treatment outcome; pharmacovigilance

Online: 19 November 2020 (13:34:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1870.v1

Polish Adaptation and Psychometric Validation of the PREM-C9 Questionnaire Dedicated for Patients with Chronic Obstructive Pulmonary Disease

Iwona Damps-Konstańska, Weronika Ciećko, Ewa Jassem, Tomasz Bandurski, Dominika Bosek, Marzena Olszewska-Karaban, Ewa Bandurska

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic obstructive pulmonary disease (COPD); Patient Reported Outcome Measures; Health Care Surveys

Online: 29 August 2023 (03:31:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0653.v1

A New Approach in the Induction of Labor with Misoprostol Vaginal Insert in High-Risk Pregnancy Obese Women

Valentin Nicolae Varlas, Georgiana Bostan, Bogdana Adriana Nasui, Nicolae Bacalbasa, Anca Lucia Pop

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: misoprostol; induction of labor; high-risk pregnancy; obesity; diabetes; hypertension; perinatal outcome

Online: 25 November 2020 (16:41:16 CET)

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Background and objectives: Induction of labor (IOL) is an event that occurs in up to one-quarter of pregnancies; less is known about the outcomes and safety of IOL in obese pregnant woman; no data is available on misoprostol vaginal insert (MVI) IOL in high-risk pregnancy obese women. Objectives: (1) to evaluate the rate of successful IOL with 200 μg MVI in obese (Body Mass Index - BMI over 30 kg/m2) high-risk pregnant women: late-term pregnancy, hypertension or diabetes, compared to obese non-high-risk ones; (2) to evaluate the safety profile of MVI in high-risk pregnancy obese patients. Study design: We conducted a cross-sectional study in "Filantropia" Clinical Hospital, Bucharest, Romania, from June 2017 to September 2019 (28 months). From a total of 11,096 registered live births, IOL was performed in 206 obese patients; 74 obese high-risk pregnant patients matched the inclusion criteria; of these, 33.8% pregnancies (n=25) were late-term (41 – 41+6 weeks), 43.2% (n=32) had associated pathologies (hypertension and diabetes); labor induction was guided using a standardized protocol. We evaluated the maternal and gestational age, parity, fetal tachysystole, hyper-stimulation, initial cervical status, time from induction to delivery, drug side effects, mode of delivery, and neonatal outcomes. Results: (a) The overall successful labor induction rate, evaluated by the vaginal delivery rate, was 71.6% (n=53), spontaneously or instrumentally assisted; 28.4% (n=21) births were unsuccessful MVI IOL, converted into caesareans. (b) No significant differences were found regarding the maternal outcomes; in terms of perinatal outcomes of safety, four cases of high-risk pregnancies vaginally delivered were associated with neonatal intensive care unit (NICU) admissions and a one-minute Apgar score under seven (5.4%). Most cases with adverse effects of misoprostol have been managed conservatively, except for three emergency C-section cases. Conclusions: Misoprostol vaginal insert is a safe choice in IOL in obese high-risk pregnancies with good maternal and perinatal outcomes.

Preprint ARTICLE | doi:10.20944/preprints201810.0228.v1

A Web-Based Calculator for Prediction of Severe Neurodevelopmental Impairment in Preterm Infants Using Clinical and Imaging Characteristics

Zachary A. Vesoulis, Nathalie M. El Ters, Maja Herco, Halana V. Whitehead, Amit M. Mathur

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: cerebellar hemorrhage; intraventricular hemorrhage; preterm; MRI; neurodevelopment; outcome prediction; white matter injury

Online: 11 October 2018 (04:21:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0326.v1

Association Between Duration of Deep Hypothermic Circulatory Arrest and Surgical Outcome in Patients with Acute Type A Aortic Dissection: A Large Retrospective Cohort Study

Mona Salehi Ravesh, Christine Friedrich, Jan Schoettler, Lars Hummitzsch, Gunnar Elke, Mohamed Salem, Georg Lutter, Thomas Puehler, Jochen Cremer, Assad Haneya

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Deep hypothermic circulatory arrest time; acute type A aortic dissection; surgical outcome

Online: 21 January 2022 (13:12:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2092.v1

Technology-Based Issues in The New Education Policy of India

Nitish Ojha, Preetish Ranjan

Subject: Social Sciences, Education Keywords: NEP; new education policy; Indian education system; technology in education; outcome based education

Online: 30 May 2023 (10:39:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0073.v1

Perceptions of Teachers and School Nurses on Child and Adolescent Oral Health

Carl A. Maida, Mavin Marcus, Di Xiong, Paula Ortega-Verdugo, Elizabeth Agredano, Yilan Huang, Linyu Zhou, Steve Y. Lee, Jie Shen, Ron D. Hays, James J. Crall, Honghu Liu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: focus group; patient reported outcome measures; oral health; education; COVID-19; dental problem

Online: 4 March 2022 (07:08:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0595.v1

Safety and Efficacy of TKIs in Very Elderly Patients (≥75 Years) with Chronic Myeloid Leukemia

Alessandro Costa, Elisabetta Abruzzese, Roberto Latagliata, Olga Mulas, Ida Carmosino, Emilia Scalzulli, Maria Laura Bisegna, Claudia Ielo, Maurizio Martelli, Giovanni Caocci, Massimo Breccia

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; tyrosine kinase inhibitor; very elderly; safety; efficacy; outcome; dose optimization

Online: 8 December 2023 (10:26:16 CET)

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Background: While outcomes of chronic phase chronic myeloid leukemia (CP-CML) patients aged over 65 years have been extensively evaluated in real-life experiences, limited data exist for the very elderly population (i.e., aged ≥ 75 years), especially for next-generation tyrosine kinase inhibitors (TKIs). In this retrospective study, we sought to evaluate the safety and efficacy of TKIs in this particular setting of patients. Methods: We conducted a retrospective analysis of a multicenter cohort of 123 newly diagnosed CP-CML very elderly patients. Results: The median age at diagnosis was 80 years (range: 75-96). In the first-line, 86.1% of patients received imatinib, 7.1% dasatinib, 5.6% nilotinib, and 0.81% received bosutinib. A total of 31 patients (25.2%) switched to second-line therapy, nine patients to a third-line and one patient to a fourth line of therapy. Resistance to treatment was the primary reason for switching therapy in both the first (64.5%) and second lines (77.7%). At diagnosis, reduced doses were administered in 36.5% of patients, in 61.2% in the second line, and in all patients in subsequent lines of therapy. In first-line setting, 71.9% of patients achieved an early molecular response (EMR, i.e. 3-month BCR::ABL1 IS <10%); at 6, 12, and 24 months, MR3 was reached by 35.7%, 55.7%, and 75.0% of patients, with 16.6%, 35.7%, and 51.7% achieving DMR at the same timepoints. Treatment-free remission (TFR) was successfully attempted in 11 patients. During the follow-up period, adverse events (AEs) were observed in 78.8% of patients, including 22 cases of cardiovascular AEs. Toxicity grade ≥ 3 was more commonly observed in patients treated with standard doses of TKIs compared to reduced doses (p=0.033). Overall, median follow-up was 46.62 months (range: 1.8-206.2), and 43 patients died due to non CML related causes. Three patients died due to disease progression to advanced (n=1) and blastic (n=2) phases. The 5-year overall survival (OS) for the entire cohort was 71.9% (95% CI: 0.63-0.81), with no significant difference between patients treated with standard doses of TKI compared to those treated with reduced doses (p=0.35). Conclusions: TKIs appear to be safe and effective even in very elderly CML patients, and dose optimization strategies yield satisfactory molecular responses for adequate disease control with an improved safety profile.

Preprint ARTICLE | doi:10.20944/preprints202306.1221.v1

Long-Term Vocational Outcome at 15 Years from Severe Traumatic and Non Traumatic Brain Injury in Pediatric Age

Sandra Strazzer, Valentina Pastore, Susanna Frigerio, Katia Colombo, Sara Galbiati, Federica Locatelli, Susanna Galbiati

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Brain Injuries; Disorders of consciousness; Childhood; Follow-Up Studies; Vocational Outcome

Online: 16 June 2023 (10:38:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1917.v1

Serum Biomarker Concentrations on Admission in Acute Traumatic Brain Injury: Associations with, TBI Severity, Toxoplasma gondii Infection and Outcome in a Referral Hospital Setting, Cameroon

Franklin Chu Buh, Germaine Sotoing Taiwe, Firas H. Kobeissy, Kevin W. Wang, Andrew I.R. Maas, Basil Kum Meh, Motah Mathieu, Eric Youm, Peter J.A. Hutchinson, Irene Ule Ngole Sumbele

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Serum biomarkers; Traumatic brain injury; CT-scan findings; outcome; Toxoplasma gondii

Online: 26 May 2023 (10:28:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0491.v1

Cross-Sectional Study on Relationships Among FoMO, Social Influence, Positive Outcome Expectancy, Refusal Self-Efficacy and SNS Usage

KUNHUA LEE, Chia-Yu Lin, Jing Tsao, Lien Fang Hsieh

Subject: Social Sciences, Psychology Keywords: FoMO; Social Cognitive Theory; Social Influence; Self-efficacy; Positive Outcome Expectancy

Online: 21 July 2020 (12:57:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1627.v1

Comparison of Unilateral versus Bilateral Instrumented Transforaminal Lumbar Interbody Fusion in Lumbar Degenerative Diseases: A Minimum of 5-Year Follow-Up

Sung Cheol Park, Jae Seong Bae, Seon Ok Jung, Kyeong-Hoon Sung, Hoon-Jae Chung

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Transforaminal lumbar interbody fusion; TLIF; Unilateral instrumentation; Bilateral instrumentation; Coronal alignment; Long-term outcome

Online: 26 September 2023 (02:48:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0484.v1

Validation of the American English Version of The Acute Cystitis Symptom Score

Jakhongir F. Alidjanov, Kurt G. Naber, Adrian Pilatz, Florian M. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Acute Cystitis Symptom Score; ACSS; cystitis; urinary tract infection; female patients; diagnosis; patient-reported outcome

Online: 18 November 2020 (16:35:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0033.v1

Perceived Credibility, Evaluation of Outcome and Attitude towards Behavioural Change in 360-Degree Assessment

Peter Cheng

Subject: Social Sciences, Behavior Sciences Keywords: 360-degree assessment; perceived credibility; evaluation of outcome; theory of reasoned action; attitude formation

Online: 6 December 2016 (11:09:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1839.v1

The Sarcoma Assessment Measure (SAM): Preliminary Psychometric Validation of a Novel Patient-Reported Outcome Measure

Lee Hulbert-Williams, Nicholas J. Hulbert-Williams, Ana Martins, Lesley Storey, Jennie Bradley, Hatty O’Sullivan, Lorna A. Fern, Maria Lawal, Rachael Windsor, Craig Gerrand, Jeremy S. Whelan, Lindsey Bennister, Mary Wells, Rachel M Taylor

Subject: Public Health And Healthcare, Other Keywords: soft tissue sarcoma; bone tumours; gastrointestinal stromal tumours; quality of life; patient-reported outcome

Online: 29 November 2023 (09:51:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0564.v1

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAMs) in Pharmaceuticals and Environmental Chemical Risk Assessment

Deepika Deepika, Vikas Kumar

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Physiologically Based Pharmacokinetic Model (PBPK); Drugs; environmental chemicals; Adverse outcome pathway (AOP); machine learning

Online: 30 December 2022 (01:30:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0411.v1

Nature of Occupational Incidents among Electrical Contractors

Pouya Gholizadeh, Behzad Esmaeili

Subject: Engineering, Architecture, Building And Construction Keywords: safety; electrical contractors; construction accidents; nature and outcome of injuries; Chi-square test of independence

Online: 31 December 2019 (11:19:50 CET)

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Electrical contractors have experienced a rise in occupational fatalities in recent years. In 2017, electrical contractors also had the second highest number of non-fatal injuries among specialty trade contractors. Identifying statistically significant dependencies between these catastrophic outcomes and a handful of well-defined contributing factors in construction accidents offers a first step in mitigating the risks of construction accidents in this trade. Therefore, this study used methodologies of descriptive and quantitative statistics to identify the contributing factors most affecting occupational accident outcomes among electrical contracting enterprises, given an accident occurred. Accident reports were collected from the Occupational Safety and Health Administration’s fatality and catastrophe database. To ensure the reliability of the data, the team manually codified more than 600 incidents through a comprehensive content analysis using injury-classification standards. Inclusive of both fatal and non-fatal injuries, the results showed that most accidents happened in nonresidential buildings, new construction, and small projects (i.e., $50,000 or less). The main source of injuries manifested in parts and materials (46%), followed by tools, instruments, and equipment (19%), and structure and surfaces (16%). The most frequent types of injuries were fractures (31%), electrocutions (27%), and electrical burns (14%); the main injured body parts were upper extremities (25%), head (23%), and body system (18%). Among non-fatal cases, falls (37%), exposure to electricity (36%), and contact with objects (19%) caused most injuries; among fatal cases, exposure to electricity was the leading cause of death (50%), followed by falls (28%) and contact with objects (19%). The analysis also investigated the impact of several accident factors on the degree of injuries and found significant effects from such factors such as project type, source of injury, cause of injuries, injured part of body, nature of injury, and event type. In other words, the statistical probability of a fatal accident—given an accident occurrence—changes significantly based on the degree of these factors. Beyond these outcomes, the described content-analysis methodology contributes to the accident-analysis body of knowledge by providing a framework for codifying data from accident reports to facilitate future analysis and modeling attempts (e.g., developing logistic regression models) to subsequently mitigate more injuries in other fields.

Preprint ARTICLE | doi:10.20944/preprints202109.0010.v1

Machine Learning Algorithms Provide Greater Prediction of Response to Scs Than Lead Screening Trial: A Predictive AI-Based Multicenter Study

Amine Ounajim, Maxime Billot, Lisa Goudman, Pierre-Yves Louis, Yousri Slaoui, Manuel Roulaud, Bénédicte Bouche, Philippe Page, Bertille Lorgeoux, Sandrine Baron, Nihel Adjali, Kevin Nivole, Nicolas Naiditch, Chantal Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: spinal cord stimulation; screening trial; infection; supervised learning; machine learning; predictive modeling; patient outcome

Online: 1 September 2021 (12:05:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0601.v1

Virological and Clinical Outcomes in Adults Treated with Ribavirin Aerosol for COVID-19 Pneumonia

Emanuela Messina, Giulia Morsica, Sabrina Bagaglio, Laura Galli, Riccardo Lolatto, Michela Sampaolo, Maxime Barakat, Robert J Israel, Antonella Castagna, Nicola Clementi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; pneumonia; ribavirin aerosol; treatment; outcome; viral load; whole genome sequencing

Online: 10 July 2023 (10:16:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1766.v1

Hypoxic-Ischemic Brain Injury in ECMO: Pathophysiology, Neuromonitoring, and Therapeutic Opportunities

Shivalika Khanduja, Jiah Kim, Jin Kook Kang, Cheng-Yuan Feng, Melissa Ann Vogelsong, Romergryko G Geocadin, Glenn Whitman, Sung-Min Cho

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: hypoxia-ischemia brain injury; extracorporeal membrane oxygenation; neurological complication; neu-romonitoring; outcome.

Online: 25 May 2023 (08:26:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0213.v1

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

Elise Goetschalkx, Djalila Mekahli, Elena Levtchenko, Karel Allegaert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: glomerular filtration rate; Brenner hypothesis; extreme low birth weight infants; renal outcome

Online: 19 January 2020 (05:12:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0444.v1

Caesareans Section Scar Ectopic Pregnancy: An Emerging Challenge

Ayman Al-Talib

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Caesarean scar ectopic pregnancy; risk factors; clinical presentation; complication; management; outcome of CSEP

Online: 19 February 2021 (14:35:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0206.v1

Human-based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State-of-the-art with a Feto-placental Organ-on-a-chip Platform

Michaela Luconi, Miguel Angel Sogorb, Udo R. Markert, Emilio Benfenati, Tobias May, Susanne Wolbank, Alessandra Roncaglioni, Astrid Schmidt, Marco Straccia, Sabrina Tait

Subject: Biology And Life Sciences, Toxicology Keywords: new approach methodologies (NAMs); adverse outcome pathways (AOPs); endocrine disruptors; animal replacement; OECD TG 414

Online: 11 November 2022 (02:00:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0271.v1

Treatment of Patients with Low Back Pain: A Comparison of Physical Therapy and Chiropractic Manipulation

Nima Khodakarami

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: chiropractic; physical therapy; treatment outcome; low back pain; therapy; economics; patient satisfaction; recurrence; health care costs; illness

Online: 20 December 2019 (07:41:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.1190.v1

Early Prediction of Mortality after Birth Asphyxia with the nSOFA

Anne-Kathrin Dathe, Anja Stein, Nora Bruns, Elena-Diana Craciun, Laura Tuda, Johanna Bialas, Maire Brasseler, Ursula Felderhoff-Müser, Britta Hüning

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Birth asphyxia; nSOFA; outcome prediction; neonate; Hypoxic-ischemic encephalopathy (HIE); therapeutic hypothermia; resuscitation; organ dysfunction; biomarker; mortality

Online: 29 April 2023 (02:52:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0264.v1

Personalized Prediction of Postconcussive Working Memory Decline: A Feasibility Study

Yung-Chieh Chen, Yung- Li Chen, Duen-Pang Kuo, Yi-Tien Li, Yung-Hsiao Chiang, Jyh-Jong Chang, Sung-Hui Tseng, Cheng-Yu Chen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: concussion; mild traumatic brain injury; working memory; long-term cognitive outcome; support vector machine classifier; personalized prediction

Online: 16 December 2021 (10:24:08 CET)

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Concussion, also known as mild traumatic brain injury (mTBI), commonly causes transient neurocognitive symptoms, but in some cases, it causes cognitive impairment, including working memory (WM) deficit, which can be long-lasting and impede a patient’s return to work. The predictors of long-term cognitive outcomes following mTBI remain unclear because abnormality is often absent in structural imaging findings. The purpose of the study was to determine whether machine learning-based models using functional magnetic resonance imaging (fMRI) biomarkers and demographic or neuropsychological measures at baseline could effectively predict 1-year cognitive outcomes of concussion. We conducted a prospective, observational study of patients with mTBI who were compared with demographically-matched healthy controls enrolled between September 2015 to August 2020. Baseline assessments were collected within the first week of injury, and follow-ups were conducted at 6 weeks, 3 months, 6 months, and 1 year. Potential demographic, neuropsychological, and fMRI features were selected according to the significance of correlation with the estimated changes in WM ability. The support vector machine classifier was trained using these potential features and estimated changes in WM between the predefined time periods. Patients demonstrated significant cognitive recovery at the third month, followed by worsened performance after 6 months, which persisted until 1 year after concussion. Approximately half of the patients experienced prolonged cognitive impairment at 1-year follow up. Satisfactory predictions were achieved for patients whose WM function did not recover at 3 months (accuracy=87.5%), 6 months (accuracy=83.3%), 1 year (accuracy=83.3%), and performed worse at 1-year follow-up compared to baseline assessment (accuracy=83.3%). This study demonstrated the feasibility of personalized prediction for long-term postconcussive WM outcomes based on baseline fMRI and demographic features, opening a new avenue for early rehabilitation intervention in selected individuals with possible poor long-term cognitive outcomes.

Preprint ARTICLE | doi:10.20944/preprints202302.0241.v1

Analysis of Interest in Becoming Social Entrepreneurs among the Millennials and Z Generation Using the Theory of Planned Behavior and Outcome Expectation: A Multigroup Analysis Approach

Florentina Kurniasari, Elissa Dwi Lestari, Herlin Handayani

Subject: Social Sciences, Sociology Keywords: Attitude Toward Behavior; Subjective Norms; Perceived Behavioral Control; Outcome Expectation; Social Entrepreneurial Intention; Generation Z; Generation Millennials

Online: 14 February 2023 (09:01:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0042.v1

Machine Learning-Based Assessment Indicates Patient-Reported Outcomes to Be Less Reliable than Clinical Parameters for Predicting 1-Year Survival in Cancer Patients.

Maria Rosa Salvador Comino, Paul Youseff, Anna Heinzelmann, Florian Bernhardt, Christin Seifert, Mitra Tewes

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Patient Reported Outcome Measure; Artificial Intelligence; Machine Learning; Predictive Analytics; Cancer Patients; Palliative Care

Online: 1 November 2023 (08:51:18 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.1082.v1

Host and HBV Interactions and Their Potential Impact on Clinical Outcome

Alexis Jose-Abrego, Sonia Roman, Saul Laguna-Meraz, Arturo Panduro

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B virus; HBV genotype H; immune response; metabolic interaction; clinical outcome; viral adaptation

Online: 15 August 2023 (08:50:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0731.v1

High CD169 Monocyte/Lymphocyte Ratio Reflects the Immunophenotyping Disruption and Predicts Oxygen Need in COVID-19 Patients

Antonella Minutolo, Vita Petrone, Marialaura Fanelli, Marco Iannetta, Martina Giudice, Ines Ait Belkacem, Marta Zordan, Pietro Vitale, Guido Rasi, Sinibaldi-Vallebona Paola, Loredana Sarmati, Massimo Andreoni, Fabrice Malergue, Emanuela Balestrieri, Sandro Grelli, Matteucci Claudia

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cytokine storm; COVID-19; CD169; inflammation; respiratory outcome; T-cell exhaustion; COVID-19 therapy

Online: 31 May 2021 (10:28:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0596.v1

Patient Reported Outcome Measure in Atopic Dermatitis Patients Treated with Dupilumab: 52-Weeks Results

Servando E. Marron, Lucia Tomas-Aragones, Carlos A. Moncin-Torres, Manuel Gomez-Barrera, Francisco Javier Garcia-Latasa de Aranibar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Atopic dermatitis; Patient Reported Outcome Measures; Dupilumab; Quality of life; Satisfaction; Efficacy; Safety; Adherence

Online: 25 May 2021 (09:15:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0032.v1

What do Users Really Want? Participatory Development of Decision Support Tools for Environmental Management based on Outcomes.

Richard J. Hewitt, C.J.A. Macleod

Subject: Social Sciences, Geography, Planning And Development Keywords: Environmental decision support systems; applications; outcome-based approach; adaptive management; user requirements; environmental management; participatory land planning

Online: 6 October 2017 (08:51:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0269.v2

Factors Predicting the Physical Activity Behavior based on Theory of Reasoned Action among Chronic Low Back Pain of the Patients Referring to Comprehensive Health Service Centers in the Shahid Beheshti University of Medical Sciences in Tehran, Iran

Mohammad Hossein Delshad, Alireza Hidarnia, Fatemeh Pourhaji

Subject: Social Sciences, Psychology Keywords: Exercise; Health Behavior; Attitudes; Referral; Quality of Life; Low Back Pain; Health Services; Models; Outcome Assessment (Health Care)

Online: 11 December 2020 (11:32:36 CET)

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Background: Low-level physical activity (PA) among Chronic Low Back Pain (cLBP) is associated with various biopsychosocial factors. This research aimed to study the predictors of PA behavior among cLBP patients. Methods: In the present study 300 eligible patients with cLBP who referred to comprehensive health service centers in the Shahid Beheshti University of Medical Sciences (SBUMS) in Tehran, Iran were random selected.To diagnose the predictors of PA behavior, all the Theory of Reasoned Action (TRA) constructs were examined as risk factors to see if they influence on the probability of PA behavior occurrence and were interpreted through odds ratio (OR). SPSS version 19 was used to analyze the data. Results: Totally 280 cLBP patients with mean age of 57.07 ±13.09 years old participated in the study. This study showed that motivation to comply significant predictor the cLBP patients for subjective norm OR (%95CI): 2.095(0.116-2.792), p-value<0.001), intention was significant predictor for perform the PA behavior OR (%95CI): 1.431(0.138-1.538), p-value <0.001), behavior beliefs could predictor for attitude OR (%95CI): 1.276(0.106-1.355), p-value= 0.002). attitude, normative beliefs, subjective norm ,and evaluation outcome behavior could predictors the cLBP patients for intention to perform the PA behavior OR (%95CI): 1.188(0.032-1.312), p-value<0.001)., OR (%95CI): 1.158(0.076-2.208), p-value=0.003) ., OR (%95CI): 1.104(0.076-1.128), p-value<0.001) ., OR (%95CI): 0.814(0.301-1.440), p-value=0.007). Conclusions: This study showed that the cLBP patients who were normative beliefs and evaluation regarding PA behavior could effect on the intention to engage in greater PA than those via other constructs (attitude and subjective norm). This study showed that the cLBP patients who were normative beliefs and evaluation regarding PA behavior could effect on the intention to engage in greater PA than those via other constructs (attitude and subjective norm). This study showed that the cLBP patients who were normative beliefs and evaluation regarding PA behavior could effect on the intention to engage in greater PA than those via other constructs (attitude and subjective norm).

Preprint ARTICLE | doi:10.20944/preprints202311.0455.v1

Lower Caesarean Section and Higher Spontaneous Vaginal Birth Rates Are Connected with Yoga Practice in Pregnancy: A Randomized Controlled Clinical Trial

Lucija Kuder, Dejan Dinevski, Vesna Elveđi Gašparović, Izidora Vesenjak Dinevski, Iztok Takač, Faris Mujezinović

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: caesarean section; caesarean section rate; caesarean section reduction; yoga; spontaneous birth; prenatal yoga; birth outcome

Online: 8 November 2023 (01:43:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2094.v1

40-Years Outcome of Old-School Non-Surgical Endodontic Treatment: Practice-based Retrospective Evaluation

Roland Frankenberger, Stephan Becker, Benedicta Beck-Broichsitter, Susanne Albrecht-Hass, Charlotte J. Behrens, Matthias J. Roggendorf, Andreas Koch

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: endodontic treatment; root canal disinfection; root canal preparation; root canal obturation; clinical outcome; root canal post; postendodontic restoration

Online: 28 December 2023 (04:30:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0735.v1

Greek Version of the Acute Cystitis Symptom Score. Part I: Linguistic Validation

Konstantinos Stamatiou, Evangelia Samara, Jakhongir F. Alidjanov, Kurt G. Naber, Adrian Pilatz, Florian M. Wagenlehner

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Greek language; translation; acute cystitis symptom score; ACSS; cystitis; urinary tract infection; female pa-tients; diagnosis; patient-reported outcome

Online: 29 December 2020 (15:40:33 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0721.v1

Efficacy of Direct Current Stimulation on Experimental Sensory Modalities and Pain Outcome Measures in Healthy Participants: Systematic Review and Meta-Analysis.

Guillermo García-Barajas, Julian Taylor, Juan Pablo Romero Muñoz, Sergio Lerma Lara, Alfonso Gil-Martínez, Josué Fernandez Carnero

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Non-invasive direct current stimulation; Cortical, Suboccipital and Spinal stimulation; Quantitative sensory testing, Pain outcome measures, Endogenous pain modulation.

Online: 30 November 2020 (11:44:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1239.v1

Combined Score Based on Match between Donor and Recipient in Age-Sex-Body Mass Index Is Related to the Evolution of the Graft after Renal Transplantation

Sergio Barroso Hernández, Álvaro Álvarez López, Elena García de Vinuesa Calvo, Jorge Alberto Rodríguez Sabillón, Teresa de Jesús Giraldo Rúa, Román Hernández Gallego, Jaime Hernán Merino, Miguel Nuno Petrucci Mauricio, Nicolás Roberto Robles Pérez-Monteoliva

Subject: Medicine And Pharmacology, Transplantation Keywords: Renal transplantation; donor-recipient matching; matching non-HLA; matching in age, gender and body mass index; renal graft outcome.

Online: 20 October 2023 (08:14:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0065.v1

Review: Influence of Vitamin D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes

Nataliia Karpova, Olga Dmitrenko, Ekaterina Arshinova, Malik Nurbekov

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: preeclampsia; neonatal outcome; vitamin D; 25(OH)D, 1,25(OH)2D; diabetes; pregnancy complication; vitamin D deficiency; vitamin D supplementation

Online: 6 October 2022 (12:16:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0454.v1

Perioperative Goal Directed Therapy During Kidney Transplantation: An Impact Evaluation on the Major Postoperative Complications

Marco Cavaleri, Massimiliano Veroux, Filippo Palermo, Francesco Vasile, Mirko Mineri, Joseph Palumbo, Lorenzo Salemi, Marinella Astuto, Paolo Murabito

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: perioperative goal-directed fluid therapy; haemodynamics monitoring; fluid management; kidney transplantation; major postoperative complications; outcome of surgery

Online: 19 November 2018 (10:57:00 CET)

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Background: Kidney transplantation is considered the first-choice therapy in ESRD patients. Despite recent improvements in terms of outcomes and graft survival in recipients, postoperative complications still concern health-care providers involved in the management of those patients. Particularly challenging are cardiovascular complications. Perioperative goal-directed fluid-therapy (PGDT) and hemodynamic optimization are widely used in high-risk surgical patients, and are associated with a significant reduction in postoperative complication rates and length of stay (LOS). The aim of this work is to compare the effects of perioperative goal-directed therapy (PGDT) with conventional fluid therapy (CFT), and to determine whether there are any differences in major postoperative complications rates and delayed graft function (DGF) outcomes. Methods: Prospective study with historical controls. Two groups, a PGDT- and a CFT- group were used: the stroke volume (SV) optimization protocol was applied in PGDT group throughout the procedure. Conventional fluid therapy with fluids titration at a central venous pressure (CVP) 8-12 mmHg and mean arterial pressure (MAP) >80mmHg was applied to the control-group. Postoperative data collection including vital signs, weight, urinary output, serum creatinine, blood urea nitrogen, serum potassium, and assessement of volemic status and the signs and symptoms of major postoperative complications occurred at 24h, 72h, 7 days and 30 days after transplantation. Results: Among the 66 patients enrolled, 33 were in each group and both groups had similar physical characteristics. Good fuctional recovery was evident in the 94% of patients. The statistical analysis has showed a difference in postoperative complications as follows: significant reduction of cardiovascular complications, DGF episodes (p<0.05) and surgical complications (p<0.01). There were no significant differences in pulmonary or other complication. Conclusions: PGDT and SV optimization effectively influenced the rate of major postoperative complications, reducing the overall morbidity and thus the mortality in patients receiving kidney transplantation.

Preprint ARTICLE | doi:10.20944/preprints202102.0059.v1

Development and Validation of a Prediction Model for 28-Day in-Hospital Mortality in Critically Ill Patients with COVID-19

Paloma Ferrando-Vivas, Doug Gould, James Doidge, Karen Thomas, Paul Mouncey, Manu Shankar-Hari, Duncan Young, Kathryn Rowan, David Harrison

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; Critical Illness; Hospital Mortality; Intensive Care Units; Outcome Assessment, Health Care; Prognosis; Risk Adjustment; Severe acute respiratory syndrome coronavirus 2

Online: 1 February 2021 (15:51:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0044.v1

Long-term Results after Autologous Breast Reconstruction with DIEP Versus PAP Flaps based on Quality of Life and Aesthetic Outcome Analysis

Angela Augustin, Evi M. Morandi, Selina Winkelmann, Ines Schoberleitner, Daniel Egle, Magdalena Ritter, Thomas Bauer, Tanja Wachter, Dolores Wolfram

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; mastectomy; autologous breast reconstruction; PAP flap; DIEP flap; donor-site morbidity; quality of life; aesthetic outcome; scar quality; Breast Q

Online: 2 December 2022 (09:57:20 CET)

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