Metal and alloy toughening was the core and long-term research direction in materials filed. As grain size had bimodal distribution, micro/nano-structured alloys presented excellent comprehensive mechanical properties, and this had become one of the research hotspots and developing trends in the field of nanotechnology. In-situ tensile test was a direct and effective method to study the deformation mechanism of materials, which revealed the multiple mechanisms responding to feature grain sizes and provided reliable experimental means and research technique. Research on development of in-situ technique and its applications in mechanical properties was reviewed in this paper according to the recent advances on the modern mechanical properties for high strength and high plasticity alloy at home and abroad. The disadvantages of the present study of preparation methods and investigation techniques for high-performance alloy had been concluded. Finally, the development prospects of high strength and high plasticity alloy materials were analyzed.

Both the use of plastic and its decomposition products lead to the distribution of plastic all over the earth and finally to the uptake by all kind of living beings including humans. Still, it is widely unknown what risks harbor the widespread uptake of plastics for human health, espe-cially regarding contributing factors like size, shape and surface composition. We assessed the uptake of polymethylmethacrylate (PMMA)-nano- and microbeads for HEK293-, A549- and MRC5 cells. Via confocal microscopy, we localized multiple PMMA-beads inside the cytosol of cells. Uptake of PMMA-beads did not alter cell growth and cell division, implying no short-term toxicity towards human cells. Further, we used a cAMP response element binding protein (CREB)-mediated reporter assay to assess whether internalized PMMA-nanobeads alter cell-signaling pathways. In contrast to the in vitro transcription, where the addition of PMMA-nanobeads abolished the transcription, no changes regarding CREB-mediated cell sig-naling are given in HEK293-cells. Our data led to the assumption that PMMA-nano-and mi-crobeads are internalized via endocytosis and end up as lysosomes within the cells cytosol. Therefore, we concluded differences regarding the surface composition of the PMMA-nanobeads mainly affect its potential to alter cell signaling. These findings emphasize the key role the sur-face composition plays regarding microplastic and its risks for human health.

Magnesium ions play an important immune-regulatory role during bone repair. For this study, we prepared micro-nano bioactive glass containing magnesium, which can release magnesium, silicon, and calcium ions and has a positive impact on osteogenic differentiation and vascular regeneration. In this study, MgMNBG was compounded and combined with PLGA and PCL for 3D printing. Afterwards, the physicochemical properties and bone repair performance of the scaffolds were evaluated through in vitro and in vivo experiments. We also investigated the effects of MgMNBG on osteogenic differentiation, immune regulation, and vascular regeneration. The results showed that MgMNBG can inhibit inflammation and promote osteogenesis and angiogenesis by regulating macrophages. PLGA/PCL/MgMNBG scaffolds have good osteogenic and angiogenic effects, and the composite scaffolds have excellent bone repair performance and potential application value.

The evolution of metals micro/nano-structure upon severe plastic deformation (SPD) is still far to be theoretically explained, while experimental datasets are persistently growing for several decades. Major problem associated with understanding of SPD is related to a fact that the latter is a synergetic product of several competing physical effects which alter the material micro/nano-structure. In attempt to find deformational boundaries, where predominantly one mechanism determines the micro/nano-structure, in this paper we propose a continuous piecewise model for the analysis of experiments on material hardness vs strain of SPD processed materials. The novelty of this approach lies in its ability to find, as free-fitting parameters, the strain breakpoints which separate different micro/nano-structure modes generated upon SPD process. The model is applied to analyse experimental data for polycrystalline samples of pure iron and two distinctive strain breakpoints are revealed with good accuracies. This finding is in a good agreement with our earlier results on TEM microscopy studies on pure iron polycrystals after SPD treatment.

In vitro fertilization (IVF) has revolutionized the field of assisted reproductive technologies (ART) by offering hope to individuals and couples struggling with infertility. Nevertheless, traditional IVF methods are not exempt from drawbacks, such as suboptimal success rates, intrusive procedures, and ethical considerations. The introduction of micro/nanorobotics in IVF offers a revolutionary chance to tackle these difficulties. This paper presents a short review of the utilization of micro/nanorobotics in IVF, investigating progress in the manipulation of sperm, retrieval of oocytes, culture of embryos, and potential future developments in this fast progressing area. In this discussion, we explore the fundamental concepts, advantages, difficulties, and possible influence of micro/nanorobotics in transforming IVF processes and enhancing patient outcomes.

In the field of clinical medicine, the real-time monitoring of carbon dioxide gas exhaled by the human body is of great significance. At present, the detection devices in the market are mainly detected by sucking a small amount of gas in the nasal cavity to the detection device, and there are some problems such as too long sampling tubes, easy blockage or distortion, and abnormal gas dispersion. In this paper, a micro-nano optical fiber sensor that can directly detect the concentration of end-tidal carbon dioxide is proposed. The measurement is achieved by using the principle of high evanescent field absorption, and the operating band is 2.004 μm. The sensor uses micro-nano optical fiber as the sensing area, and then detects the presence of carbon dioxide gas exhaled by human body through optical power attenuation. The function of micro-nano fiber is to realize the transmission of signal light and also serve as the absorption medium of the gas to be measured. In addition, the variation of light power also reflects the respiratory cycle of the human body. The sensor can realize rapid real-time response to carbon dioxide gas detection, with small size, low cost, and easy to replace. It has great application potential in clinical scenarios such as Gastrointestinal Endoscopes that require real-time monitoring of human respiration.

This paper discusses the basic concepts of phase dislocations and vortex formation in the electric fields of fundamental air core mode of hollow core waveguides with specific types of rotational symmetry of the core – cladding boundary. Analysis of the behavior of the electric field phase in the transmission bands shows that the mechanism of light localization in the hollow core waveguides with discrete rotational symmetry of the core – cladding boundary cannot be completely described by the ARROW model. For an accurate description of the phase behavior, it is necessary to account for phase jumps of the magnitude of π when passing through the phase dislocations.

The size of TiO2 (either nanometric or micrometric) can significantly affect both its photocatalytic and photoelectrochemical properties, thus altering the photooxidation of organic pollutants in air or water. The purpose of this work is to give an account of the photoelectrochemical and photocatalytic features of some nano- and micro-sized TiO2 commercial powders towards a model reaction, the photooxidation of acetone. Cyclic voltammograms (CV) of TiO2 particulated electrodes under UV illumination experiments were carried out in either saturated O2 or N2 solutions for a direct correlation with the photocatalytic process. In addition, the effect of different reaction conditions on the photocatalytic efficiency under UV light in both aqueous and gaseous phases was also investigated. CV curves with the addition of acetone under UV light showed a negative shift of the photocurrent onset, confirming the efficient transfer of photoproduced reactive oxygen species (ROSs), e.g., hydroxyl radicals, or holes to acetone molecules. The photocatalytic experiments showed that the two nano-sized samples exhibit the best photocatalytic performance. The different photoactivity of the micro-sized samples is probably attributed to their morphological differences, affecting both the amount and distribution of free ROSs involved in the photooxidation reaction.

A facile and novel synthesis of thirteen 2-amino-3-cyanopyridine derivatives 5(a-m), by a one-pot multicomponent reaction (MCRs), is described for the first time, starting from aromatic aldehydes, malononitrile, methyl ketones, or cyclohexanone and ammonium acetate in the presence of the nanostructured diphosphate Na2CaP2O7 (DIPH) at 80 °C, under solvent-free conditions. These compounds were synthesized in short reaction times with good to excellent yields (84-94%). The diphosphate Na2CaP2O7 is used as an efficient catalyst, environmentally, easy handling, non-toxic, stable, and reusable. Our study was strengthened by the synthesis of five new pyrido[2,3-d]pyrimidine derivatives 6(b, c, g, h, j) by intramolecular cyclization of 2-amino-3-cyanopyridines 5(b, c, g, h, j), with formamide. The synthesized products were characterized by FT-IR, SEM, XRD, TEM, 1H NMR, 13C NMR, TLC, and BET. The operating conditions were optimized using a model reaction in which the catalyst amount, temperature, time, and solvent effect were evaluated. The antibacterial activity was tested against Gram-positive and Gram-negative strains for the synthesized compounds.

Micro nano bubbles (MNBs) can generate ·OH in situ, which provides a new idea for the safe and efficient removal of pollutants in water supply systems. However, the difficulty in obtaining stable MNBs causes the low efficiency of ·OH generation, which makes the inability to guarantee the removal efficiency of pollutants. This paper reviews the application research of MNBs technology in water security from three aspects: the generation process of MNBs in water, the generation rule of ·OH during MNBs collapse, and the control mechanism of MNBs on pollutants and biofilms. We found that MNBs generation methods are divided into chemical and mechanical (about 10 kinds) categories, and the instability of bubble size restricts the application of MNBs technology. The generation of ·OH by MNBs is affected by pH, gas source, bubble size, temperature, external stimulation. And pH and external stimulus have more influence on ·OH generation in situ than other factors. Adjusting pH to alkaline or acidic conditions and selecting ozone or oxygen as the gas source can promote the ·OH generation. MNBs’ collapse also releases a large amount of energy, which the temperature and pressure can reach 3000K and 5Gpa respectively, making it efficient to remove ≈90 % of pollutants (i.e., trichloroethylene, benzene, and chlorobenzene). The biofilm can also be removed by physical, chemical, and thermal effect. MNBs technology also has great application potential in drinking water, which can be applied to improve water quality, optimize household water purifiers, and enhance the taste of bottled water. Under the premise of safety, let people of different ages taste, finding that compared with ordinary drinking water, 85.7 % of people think MNBs water is softer, 73.3 % of people think MNBs water is sweeter. This further proves that MNBs water has a great prospect in the drinking water application. This review provides innovative theoretical support for solving the problem of drinking water safety.

The 1060 aluminium alloy is widely applied to electronic industry, construction area, aerospace field, traffic engineering, decoration and consumption goods market for its good chemical, physical and mechanical properties. In general, excellent processing property is necessary and important for manufacturing of complicated panels. In this paper, a special 2D ultrasonic vibration incremental forming method is designed to improve its plasticity and mechanical properties. Three kind of processing methods including traditional single point incremental forming, longitudinal ultrasonic vibration incremental forming and 2D ultrasonic vibration incremental forming are conducted for flexible manufacture of conical parts of 1060 aluminium alloy sheet. Then micro-hardness tests, residual stress tests and scanning electron microscopy tests are carried out to probe its revolution of micro-structure and mechanical properties and to analysis the effects of different types of ultrasonic vibration on plasticity and fracture characteristic of 1060 aluminium alloy. It is proved that 2D ultrasonic vibration is facilitated to improvement of plasticity and surface qualities of 1060 aluminium alloy than the other two processing methods. So, the novel 2D ultrasonic vibration incremental forming possesses substantial application values on flexible and rapid manufacturing of complicated thin-walled component of aluminium alloy.

Using analysis methods such as Rutherford backscattering Spectrometry, scanning electron microscopy, X-ray diffraction, and Raman spectroscopy, the diffusion behavior of iodine in micro/nano-porous graphite under high-temperature conditions was studied. The results indicate that iodine diffusion leads to the contraction of graphite microcrystals, a decrease in interlayer spacing, and an increase in defect density, resulting in a reduction in microcrystal size. Upon diffusion of iodine out of iodine-loaded graphite, the microcrystal size of the graphite increases, the interlayer spacing appears to return to the initial state, and the defect density decreases. By comparing the iodine diffusion performance of nanoporous graphite G400 and G450 with microporous graphite G500, it was determined that nanoporous graphite exhibits better inhibition of iodine diffusion compared to microporous graphite. Studying the diffusion behavior of iodine in micro/nano-porous graphite has significant academic significance and engineering value for the screening, design, and performance optimization of nuclear graphite.

Micro satellites must survive severe mechanical conditions during their launch phase. Therefore, structural design requirements are imposed on the micro satellites. These requirements are the strength requirement and the stiffness requirement. Usually, the structural design of a micro satellite is performed using the internal stress analysis and the natural frequency analysis, which are based on a Finite Element Method (FEM). The validity of this structural design is evaluated through vibration tests. In an early stage of development, which has a FEM model of a satellite in the process of creation, presumption of the natural frequency of a satellite may be difficult. In this study, a simple method for determining the longitudinal and lateral minimum natural frequencies of the micro satellites during the ascent phase was clarified. The structure of the micro satellites used in this research is made of aluminum alloy, and they have a monocoque structure. The Young's modulus and moment of inertia of area used to calculate the minimum natural frequencies were determined using the area ratio of the monocoque structure to the entire satellite. When this method is used, the estimated minimum natural frequencies of the longitudinal direction and the lateral direction are in agreement with the measured values acquired by the vibration tests. In order to shorten the process of micro satellites development, this paper describes a practical estimation method of the minimum natural frequency for micro satellites.

With the increasing demand for energy worldwide, researchers from different fields have been striving to improve the sustainability and proper utilization of energy resources. Passive radiative cooling, as a natural energy transport method, can achieve cooling without additional external energy input. This review provides a comprehensive examination of passive radiative cooling, including its fundamental theories and latest development. A particular emphasis is placed on the diverse range of fields where passive radiative cooling has been applied, notably including but not limited to construction and architecture. The current state of applications, potential challenges that may arise with wider adaption and promising research directions for each field are thoroughly discussed. This review underscores the universal applicability and feasibility of passive radiative cooling and contributes to its future development by identifying promising areas for further exploration.

Lamellar eutectic structure of Al_0.7CoCrFeNi high-entropy alloy (HEA) is emerging as a promising candidate for structural applications because of its high strength-ductility combination. The alloy consists of a fine-scale lamellar fcc+B2 microstructure with high flow stresses >1500 MPa under quasi-static conditions. The response to shear loading was not investigated so far. This is the first report on the shear deformation of an eutectic structured HEA and effect of precipitation on shear deformation. The dynamic shear response (DSR) of the eutectic HEA was examined in two microstructural conditions, with and without the presence of L1₂ precipitates. A split-Hopkinson pressure bar (SHPB) was used to compress the hat-shaped specimens to study the local DSR of the alloy. The adiabatic shear bands (ASBs) in two different microstructural conditions were characterized after deformation at dynamic strain rates. The adiabatic shear localization occurs at low strains for the high strength material, and the eutectic microstructure does not delay cracking. The width of ASBs and the extent of plastic deformation around them has been correlated with the rate of straining. Dynamic recrystallization within ASBs and profuse twinning around it was observed. Local mechanical response of individual lamellae before and after shear deformation was examined using nano-indentation.

Micro channel tube (MCT) is widely employed in industry due to its excellent efficiency in heat transfer. An MCT is commonly produced through extrusion within a porthole die, where severe plastic deformation is inevitably involved. Moreover, the plastic deformation, which dramatically affects the final property of the MCT, varies significantly from location to location. In order to understand the development of the microstructure and its effect on the final property of the MCT, the viscoplastic self-consistent (VPSC) model, together with the finite element analysis and the flow line model, is employed in the current study. The flow line model is used to reproduce the local velocity gradient within the complex porthole die, while VPSC model is employed to predict the evolution of the microstructure accordingly. In addition, electron backscatter diffraction (EBSD) measurement and mechanical tests are used to characterize the evolution of the microstructure and the property of the MCT. The simulation results agree well with the corresponding experimental ones. The influence of the material’s flow line on the evolution of the orientation and morphology of the grains, and the property of the produced MCT are discussed in detail.

Extracellular vesicles (EV) such as exosomes, are newly recognized fundamental, natural and physiologic particles of life that seemingly are involved all biologic processes and clinical diseases. Due to their universal involvements, understanding the nature and the potential therapeutic uses of these nano-vesicles requires innovative experimental approaches, in virtually every field. Of the EV group, exosome nano-vesicles and larger companion extracellular micro vesicles (MV) can mediate completely new phenomena dependent on intercellular transfer of proteins and selected RNAs; particularly miRNAs, between donor and targeted cells to elicit epigenetic alterations inducing functional cellular changes. These recipient acceptor cells are nearby (paracrine transfers) or far away after distribution via the circulation (endocrine transfers). The major properties of such vesicles seem to have been conserved over eons, suggesting that they may have ancient evolutionary origins arising perhaps even before cells in the primordial soup from which life evolved. Their potential ancient evolutionary attributes may be responsible for the ability of some modern day exosomes to withstand unusually harsh conditions; perhaps due to unusual membrane lipid compositions. This is exemplified by maternal milk exosome survival of the neonatal acid/enzyme rich stomach. It is postulated that this also applies to their durable presence in phagolysosomes; suggesting unique intracellular release of contents. A major issue discussed is the generally poorly realized superiority of these naturally evolved nano vesicles to therapies compared human engineered artificial nanoparticles; say for treatment of cancers.

Keywords: friction stir processing; additive manufacturing; wire; titanium alloy; material transfer; microstructure; microhardness

The human body contains 60-70% of water, depending on age. As a body fluid, it is not only a medium in which physical and chemical processes take place, but it is also one of the active mediators. Water is the richest substance with non-covalent hydrogen bonds. Water molecules, by themselves (in vacuum), are diamagnetic, but when organized into clusters, become diamagnetic or paramagnetic. Also, biomolecules (DNA, collagen, clathrin, and other proteins) have non-covalent hydrogen bonds in their structure. The interaction, as well as signal transmission, between water and biomolecules is achieved through the vibrations of covalent and non-covalent hydrogen bonds, which determine the state and dynamics of conformational changes of biomolecules. Disruptive conformational changes of biomolecules, cells, and tissues lead to their dysfunctionality, so they are a frequent cause of many disorders and diseases. For example, the rearrangement of hydrogen bonding due to mitochondrial disease mutation in cytochrome bc1 disturbs heme bH redox potential and spin state. In order to prevent and repair the dysfunctional conformational changes, a liquid substance was developed based on the second derivative of the C₆₀ molecule (SD-C₆₀), which has classical and quantum properties. Characterization of SD-C₆₀ by UV-VIS-NIR, FTIR, TEM, and AFM/MFM was done and it is shown that SD-C₆₀ water layers generate vibrations with near-zero phase dispersion which are transmitted through the Fibonacci’s water chains to biomolecules. In comparison to previously published SD-C₆₀ derivate (3HFWC, size until 10 nm, and 1-5 water layers), improved formulation (3HFWC-W, size 10-25 nm, and 6-9 water layers) showed multiplied cytotoxic activity against melanoma cell lines of different aggressiveness. Apart from this, the mode of action was preserved and based on induction of senescence rather than cell death. Importantly, high selectivity toward malignant phenotype was detected. Observed effects can be ascribed to a machinery of hydrogen bonds, which are generated in SD-C₆₀ and transmitted through water to biomolecules. This approach may open a new field in science and healthcare - a “water-based nanomedicine”.

Nano medicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future. The current medical field is in dire need of new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging. Here in this experimental study, the nano materials used in DNA biosensors like silver nano dots were incorporated as nano biosensors are used for both therapeutic and diagnostic applications. The most important step while preparing a DNA biosensor is the immobilization of DNA probe on the surface of a sensing device such as an electrode. The amount of immobilized DNA probe will influence the accuracy sensitivity, selectivity and life of a DNA biosensor directly. Because of the high surface to volume ratio and excellent biological compatibility, nano materials can enlarge the sensing surface area to increase the amount of immobilized DNA and the DNA mixed with nano materials can keep its biologically activity well.In this study,silver nano dots created in our lab were functionalized with thio nucleides and were used as nano sensor probes in bio bar code assays.

This work presents the results of the experimental and theoretical study of the static pull-in of tilting actuation executed by a hybrid levitation micro-actuator (HLMA) based on the combination of inductive levitation and electrostatic actuation. A semi-analytical model to study such the pull-in phenomenon is developed, for the first time, as a result of using the qualitative technique based on the Lagrangian approach to analyze inductive contactless suspensions presented in work and a recent progress in the calculation of mutual inductance and force between two circular filaments. The obtained non-linear model, accounting for two degrees of freedom of the actuator, allows us to predict accurately the static pull-in displacement and voltage. The results of modelling were verified experimentally and agree well with measurements.

Control of autonomous robot motion in radial mass density field is presented. In that sense the robot motion is described as the function of the radial mass density parameters. The radial mass density field is between the maximal radial mass density and the minimal radial mass density. Between these two limited values one can use n points (n = 1, 2, . . . nmax) and calculate the related radial mass density for each point. The radial mass density is maximal at the minimal gravitational radius and minimal at the maximal gravitational radius. This conclusion is valid for Planck scale, but also for the scales that are less or higher of that one. Using the ratio of the Planck mass and Planck radius it is generated energy conservation constant with value κ = 0.99993392118. Further, in this theory it is possible to connect Planck’s and gravitational parameters as functions of the maximal (or minimal) radial mass density. In that sense the autonomous robot motion in radial mass density field is important for the control of the robot motion at micro and nano scales.

When a limb suffers a fracture, rupture, or dislocation, it is traditionally immobilized with plaster. This may induce discomfort in the patient, excessive itching and sweating, which creates the growth of bacteria, leading to an unhygienic and difficulty to keep clean from treatment. Furthermore, if the plaster remains for a long period, it may cause lesions in the joints and ligaments. To overcome all these disadvantages, orthoses have emerged as important medical devices to help patients in rehabilitation, as well as for self-care of deficiencies in clinics and daily life. Traditionally, these devices are produced manually, which becomes time-consuming and error prone. From another point-of-view, it is possible to use imageology (X-ray or computed tomography) to scan the human body; a process that may help orthoses manufacturing but induces radiation to the patient. To overcome this great disadvantage, several types of 3D scanners, without any kind of radiation have emerged. This article describes the use of various types of scanners capable of digitizing the human body, to produce custom orthoses. Studies have shown that photogrammetry is the most used and most suitable 3D scanner for the acquisition of the human body in 3D. With this evolution of technology, it is possible to decrease the scanning time and it will be possible to introduce this technology in clinical environment.

The occurrence of potential spikes in a cell is a sign of life, and it is called action potential. There is a common notion that neuron signal conduction is the conduction of action potential. Hence, action potential is a typical and essential life activity. However, such potential spikes occur even in simple nonliving systems. According to the experimental observations by Pollack, structured water molecules can generate a negative potential environment. From this observation, the potential spike generation process for both living and nonliving systems caused by ion and water molecule adsorption-desorption process could be explained in this paper. So, taking into consideration the electrically neutral water molecules,the action potential generation mechanism could be explained. It is a fully inanimate model. Hence, the action potential may not be a life activity. Here, the role of water molecules in life is investigated further. It was found that the phase transition of the membrane is involved in the neuron signal conduction, but the membrane phase transition could be due to the change of state of the water molecules, which forms a large-scale structure in the cavities created by a number of lipids.

Fluorescence microscopy provides an unparalleled tool for imaging biological samples. However, producing high-quality volumetric images quickly and without excessive complexity remains a challenge. Here, we demonstrate a simple multi-camera structured illumination microscope (SIM) capable of simultaneously imaging multiple focal planes, allowing for the capture of 3D fluorescent images without any axial movement of the sample. This simple setup allows for the acquisition of many different 3D imaging modes, including 3D time lapses, high-axial-resolution 3D images, and large 3D mosaics.

While laminar flow heat transfer and mixing in microfluidic geometries has been investigated experimentally, as has the effect of geometry-induced turbulence in microfluidic flow (it is well documented that turbulence increases convective heat transfer in macrofluidic flow), little literature exists investigating the effect of electrokinetically-induced turbulence on heat transfer at the micro scale. Using recently observed experimental data, this work employed computational fluid dynamics coupled with electromagnetic simulations to determine if electrokinetically-forced, low-Reynolds number turbulence could be observed in a rectangular microchannel with using Newtonian fluids. Analysis of the results was done via comparison to the experimental criteria defined for turbulent flow. This work shows that, even with a simplified simulation setup, computational fluid dynamics (CFD) software can produce results comparable to experimental observations of low-Reynolds turbulence in microchannels using Newtonian fluids. In addition to comparing simulated velocities and turbulent energies to experimental data this work also presents initial data on the effects of electrokinetic forcing on microfluidic flow based on entropy generation rates.

Curcumin, a polyphenol with a rich history spanning two centuries, has emerged as a promising therapeutic agent targeting multiple signaling pathways and exhibiting cellular-level activities that contribute to its diverse health benefits. Extensive preclinical and clinical studies have demonstrated its ability to enhance the therapeutic potential of various bioactive compounds. While its reported therapeutic advantages are manifold, predominantly attributed to its antioxidant and anti-inflammatory properties, its efficacy is hindered by poor bioavailability stemming from inadequate absorption, rapid metabolism, and elimination. To address this challenge, nano-delivery systems have emerged as a promising approach, offering enhanced solubility, biocompatibility, and therapeutic effects for curcumin. We have analyzed the knowledge on curcumin nano-encapsulation and its synergistic effects with other compounds, extracted from electronic databases. We discuss the pharmacokinetic profile of curcumin, current advancements in nano-encapsulation techniques, and the combined effects of curcumin with other agents across various disorders. By unifying existing knowledge, this analysis intends to provide insights into the potential of nano-encapsulation technologies to overcome constraints associated with curcumin treatments, emphasizing the importance of combinatorial approaches in improving therapeutic efficacy. Finally, this compilation of study data aims to inform and inspire future research into encapsulating drugs with poor pharmacokinetic characteristics and investigating innovative drug combinations to improve bioavailability and therapeutic outcomes.

This work emphasizes to use silver decorative method to enhance the antibacterial activity of TiO₂ and ZnO nanoparticles. These silver decorated nanoparticles (hybrid nanoparticles) were synthesized by using sodium borohydride as a reducing agent, with the weight ratio of Ag precursors: oxide nanoparticles = 1: 30. The morphology and optical property of these hybrid nanoparticles were investigated using transmission electron microscopy (TEM) and UV–vis spectroscopy. The agar-well diffusion method was used to evaluate their antibacterial activity against both Staphylococcus aureus and Escherichia coli bacteria, with or without light irradiation. The TEM images indicated clearly that silver nanoparticles (AgNPs, 5-10 nm) were well deposited on the surface of nano-TiO₂ particles (30-60 nm). Besides, smaller AgNPs (< 2 nm) were dispersed on the surface of nano-ZnO particles (20-50 nm). UV-vis spectra confirmed that the hybridization of Ag and oxide nanoparticles led to shift the absorption edge of oxide nanoparticles to the lower energy region (visible region). The antibacterial tests indicated that both oxide pure nanoparticles did not exhibit inhibitory against bacteria, with or without light irradiation. However, the presence of AgNPs in their hybrids, even at low content (< 40 mg/mL) leads to a good antibacterial activity and the higher inhibition zones under light irradiation as compared to that in dark was observed.

The three-point bending behavior of a single Au nanowire deformed with an atomic force microscope was monitored by coherent X-ray diffraction using a sub-micrometer sized hard X-ray beam. While three-dimensional reciprocal-space maps were recorded before and after deformation by standard rocking curves, they were measured by scanning the energy of the incident X-ray beam during deformation at different loading stages. The mechanical behavior of the nanowire is visualized in reciprocal space and a complex deformation mechanism is described. In addition to the expected bending of the nanowire, torsion is detected. Bending and torsion angles are quantified from the high resolution diffraction data.

Real and complex analytic functions are largely studied in the field of complex analysis and are seen as very useful tools in solving problems in mathematics, physics and engineering. Real and complex numbers are a subset of semi-structured complex numbers (a new number set created to algebraically solve division by zero). Nevertheless, the properties of analytic functions made up of semi-structured complex variables (called semi-structured complex analytic functions) is yet to be explored. This limits the range of possible problems that can be resolved using analytic functions). In this regard, the aim of this paper was to expound upon the properties of semi-structured complex analytic functions and show their application in solving engineering problems. The results of this paper included (1) developing a full set of Cauchy–Riemann Equations for the semi-structured complex -space; (2) define sufficient and necessary conditions for a semi-structured complex function to be analytic; (3) determine the relationship between semi-structured complex analytic functions, Laplace’s Equations and Poisson’s Equations; and (5) provide an example of the use of these functions.

As a growing public interest in social health of elderly, studies focusing on social networks and interpersonal relationships of the elderly are needed. The present study was conducted to de-velop a structured interview to evaluate the interpersonal schema based on Self-Defining Memory of elderly. First, the word cues that the elderly often report on interpersonal events were con-firmed. Next, the indices and scoring rules were prepared, including Relationship frequency (RF), Conflict frequency (CF), Dominance mean (Dm), and Warmth mean (Wm). Healthy elderly peo-ple living alone (mean age = 71.81, SD = 3.95) were interviewed. Finally, the correlation between each index and Short form of Korean Inventory of Interpersonal Problems Circumplex Scales (KIIP-SC) was analyzed for criterion validity. The inter-rater reliability was substantial (Kappa = .61 ~ .66). Based on the analysis of criterion validity, the indices of CF, Dm, and Wm indices showed an appropriate level of criterion validity. This study developed a structural interview based on a novel system of reporting autobiographical memory and established indices with appropriate validity to evaluate interpersonal relationships. The interview is expected to identify the characteristics of interpersonal relationships of the elderly and contribute to the establishment of the elderly community, accordingly.

In recent years, antimicrobial resistance in many human pathogens has become a serious health concern. Since infections with resistant pathogens cannot be treated with traditional antimicro-bial drugs, new strategies are necessary to fight bacterial infections. Hybrid nano-systems may provide a solution to this problem, by combining multiple mechanisms for killing bacteria to synergistically increase the effectiveness of the antimicrobial treatment. In this review, we high-light recent advances in the development of hybrid nano-systems for the treatment of bacterial infections. We discuss the use of hybrid nano-systems for combinational therapy, focusing on various triggering mechanisms for drug release and the development of biomimetic nanomateri-als. We also examine inherently antimicrobial nano-systems and their uses in preventing infec-tions due to wounds and medical implants. This review summarizes recent advances and pro-vides insight into the future development of antimicrobial treatments using hybrid nanomateri-als.

Micro-technology has played a substantial role in bioscience, biomedical and biotechnological research due to its core advantages in modern science and engineering. It has created unique development in various sectors of bio-research and upsurges the efficacy of research at the molecular level in recent years. Microfluidic technology makes it possible to manipulate sample volumes at the micro- and nano-level (called nanofluidics) with terrific control outside in vivo cellular microenvironment, enabling the reduction of discrepancies between in vivo and in vitro environments as well as reducing reaction time and cost. In this review, we discuss various effective integrations of microfluidic technologies into biotechnology and its paradigmatic significance in bio-research, supporting mechanical and chemical in vitro cellular micro-environment. Specific innovations relating to the application of microfluidics to advance microbial life, solitary and co-cultures along with a multiple-type cell culturing, cellular communications, cellular interactions and population dynamics are discussed.

Drought is one of the leading abiotic factors limiting morphological and physiological activities in blackberry cultivation. We investigated the effect of silver nanoparticles (AgNPs) on morphological and physiological processes in the boysenberry crop (Rubus ursinus Chamisso &amp; Schlenhtendal) under drought stress. The experiment was performed with three drought stress levels (0% PEG, 4% PEG and 8% PEG) and three AgNPs treatments (0, 0.1, 0.2 mg L−1) invitro conditions. The results showed that drought stress induced by PEG, reduced root and shoot development of boysenberry plants grown invitro. The addition of AgNPs is significantly alleviated the adverse effect of drought stress and increased the plant growth parameters. Antioxidant activity of SOD and CAT enzymes increased in boysenberry leaves when treated with AgNPs under drought conditions, while the amount of MDA decreased. Therefore, the results obtained in this study suggest that 0.1 mg L-1 AgNPs added to the medium improve the growth and development of invitro boysenberry plants under drought stress.

Ultra-short 230 fs laser pulses of 515 nm wavelength were tightly focused into 700 nm focal spots and utilised in opening ~ 400 nm nano-holes in a Cr etch mask that was tens-of-nm thick. Nano-holes ablated at slightly above the threshold of ablation irradiance became nano-disks and nano-rings at slightly lower pulse energies. Subtle sub-1 nJ pulse energy control was harnessed to pattern large surface areas with controlled nano-alloying of Si and Cr. This technique is extendable to vacuum-free large area patterning of nanolayers by alloying them at distinct locations with sub-diffraction resolution. Such metal masks with nano-hole opening can be used for formation of random patterns of nano-needles with sub-100 nm separation when applied to dry etching of Si.

Electro-spun ultra-fine fibers exhibit two significant properties: a high surface-to-volume ratio and a relatively defect-free molecular structure. Due to the high surface-to-volume ratio, electro-spun materials are well suited for activities requiring increased physical contact, such as providing a site for a chemical reaction or filtration of small-sized physical materials. However, electrospinning has many shortcomings, including difficulties in producing inorganic nanofibers and a limited number or variety of polymers used in the process. The fabrication of nanofiber bundles via electrospinning is explored in this analytical study, as well as the relationship between extrinsic electrospinning parameters and the relative abundance of various fiber morphologies. Numerous variables could impact the fabrication of nanofibers, resulting in a variety of morphologies; therefore, adequate ambient conditions and selecting the appropriate solvent for achieving a homogenous polymer solution and uniform electro-spun materials are examined. Finally, common polymers suitable for electrospinning and the promising applications of ultra-fine fibers achieved via electrospinning are studied in this paper.

The research progress of nano-hydroxyapatite and its composite biomaterials, which are widely used, is summarized. The preparation techniques and applications of nano-hydroxyapatite and its composites in tissue engineering scaffolds, sustained and controlled release drug carriers, targeting drug delivery and environmental functional materials show that nano-hydroxyapatite and its composites will have good prospects in the field of biomedicine. The nano-hydroxyapatite composite biomaterial is a first phase or multi-phase material added to the nano-hydroxyapatite to obtain a favorable histological reaction, satisfactory strength and rigidity, and to synthesize a scaffold material for tissue regeneration. As a scaffold for guiding bone tissue regeneration, nano-hydroxyapatite composite material can also be used as a targeted drug release system for drug delivery system. It has good biocompatibility and degradability and has become a research hotspot in bone tissue engineering. The complex is expected to be applied to medical diagnostic fields such as tumor cell detection and nano biological probes.

This review focuses on an extensive synopsis of the recent improvements in the field of CO2 hydrogenation over structured zeolites including their properties, synthesis methods, and characterization approaches. The role of bimodal mesoporous structures surface oxygen vacancies, and the Si/Al ratio in improving catalytic activity is highlighted. The porosity, thermal stability, and structural integrity are also discussed in the review along with how structured zeolites are affected by electrical and plasma interactions. The synthesis methods are analyzed in detail by comparing the benefits and drawbacks of the bottom-up techniques, such as hard templating, soft templating, and non-templating on the one side; and the top-down approaches, e.g. dealumination, desilication, and recrystallization on the other. This review also draws attention to the necessity of overcoming the difficulties arising from these synthesis techniques, for example, micropore-induced diffusion restrictions and morphological constraints, employing innovative approaches and optimization strategies. Conventional and advanced characterization techniques are pointed out in this respect as crucial for understanding the catalytic mechanism and the dynamic behavior, hence, beneficial in the advancements of research on structured zeolites with higher efficiency and activity. The review ends with a perspective that highlights the necessity of further research in the improvement of synthesis approaches and characterization procedures of the structured zeolites to increase their catalytic activity in CO2 hydrogenation, a critical process of paramount importance in the global effort to reduce excessive carbon emissions and combat climate change..

Cross-industry clusters are important for the economic prosperity of a region. However, studies are lacking to address competitive clusters among the aviation and tourism industries. Thus, this paper considers the case of both industries in terms of clusters and synergies formed. This research aim is to provide an understanding of both industries' protagonists' involvement in contributing to knowledge insights on the establishment of synergies or clusters among the two industries. Cyprus is highly dependent on tourism and aviation because they facilitate connectivity. The research is filled with semi-structured interviews with the main players and organizations of the airline and tourism industries (government bodies, airports, airlines, tour operators, and hotels). The results are indicative and suggest that, in a small geographical context, the notion of clusters involves a synergetic relationship among tourism stakeholders. Airlines’ role is important because it has an effect on all stakeholders involved in tourism.

The controllability and consistency in the fabrication of micro-textures on large-scale remains a challenge for existing production processes. Mask electrolyte jet machining (MEJM) is an alternative to Jet-ECM for controllable and high-throughput surface microfabrication with more consistency of dimensional tolerances. This hybrid configuration combines the high-throughput of masked-ECM and the adjustable flow-field of jet-ECM. In this work, a duckbill jet nozzle was introduced to make MEJM more capable of batch micro-structuring. A multiphysics model was built to simulate the distribution of electrochemical reaction ions, the cur- rent density distribution and the evolution of the shape of the machined cavity. Experimental investigations are presented showing the influence of the machining voltage and nozzle moving speed on the micro cavity. Several 35 ×35 micro cavity arrays with a diameter of 24.92 − 11.73 µm and depth of 15.86 − 7.24 µm are generated on 304 stainless steel.

We report a 92 channel RF channelizer based on a 48.9 GHz integrated micro-comb that operates via soliton crystals, together with a passive high-Q ring resonator that acts as a periodic filter with an optical 3dB bandwidth of 121.4 MHz. We obtain an instant RF bandwidth of 8.08 GHz and 17.55 GHz achieved through temperature tuning. These results represent a major advance to achieving fully integrated photonic RF spectrum channelizers with reduced low complexity, size, and high performance for digital-compatible signal detection and broadband analog signal processing.

The steady streaming (SS) phenomenon is gaining increased attention in the microfluidics community, because it can generate net mass flow from the zero-mean vibration. We developed numerical simulation and experimental measurement tools to analyze this vibration induced flow, which has been challenging due to its unsteady nature. Validity of these analysis methods is confirmed by comparing the three-dimensional (3D) flow field induced around a cylindrical micropillar under circular vibration. In the numerical modeling, we directly solved the flow in the Lagrangian frame so that the substrate with a micropillar becomes stationary, and the result was converted to the Eulerian frame to compare them with the experimental results. The present approach enables to avoid the introduction of moving boundary or small perturbation approximation. The flow field obtained by the micro particle image velocimetry (PIV) measurement supported the three-dimensionality observed in the numerical results, which could be important for controlling the mass transport and manipulating particulate objects in the microfluidic systems.

In this paper, we present an experimental procedure to enhance the dimensional accuracy of fabrication via Stereolithography (SLA) of features at the micro-scale. Using a custom benchmark part, deviations in feature dimensions (micro-pores diameters and depths) were detected and measured by confocal microscopy. Samples characterization and experimental observations allowed the identification of inaccuracy sources, mainly due to the laser beam scanning strategy and to the incomplete removal of uncured liquid resin in post-processing (i.e., IPA washing). As a technology baseline, the measured dimensional errors on pores diameters were up to -46%. A compensation method of the nominal laser spot diameter (85m) was defined and implemented resulting in relevant improvements in dimensional accuracy of 9.8% and 11.3% on full-open pores diameter and depth, respectively. Further investigation was performed on a customized test part to adjust the calibration procedure. The measurements revealed that the estimate of the laser beam spot size is 968m. Measurements on micro-pores having different sizes revealed that a constant compensation parameter (i.e., C=85, 96, 120m) is not fully effective at the micro-scale, where average errors still remain at -24%, -18.8%, and -16% for compensations equals to 85, 96 and 120m, respectively. A further experimental campaign allowed the identification of an effective nonlinear compensation law where the compensation parameter depends on the micro-feature size C= f (D). Results show a sharp improvement in dimensional accuracy on micro-pore fabrication, with errors consistently below +8.2%. The proposed compensation method can be extended for the fabrication of any micro-features without restrictions on the specific technology implementation. Concerning the inaccuracy introduced by the laser path, experimentation with a customized part allowed the optimization of the part orientation to reduce the errors and their differences along the X and Y machine axes.

In a recent paper discussing Newton’s third law in the framework of special relativity for charged bodies, it was suggested that one can construct a practical relativistic motor provided high enough charge and current densities are available. As on the macroscopic scale charge density is limited by the phenomena of dielectric breakdown, it was suggested to take advantage of the high charge densities which are available on the microscopic scale. A preliminary analysis of this option denoted "nano relativistic scale" is studied in the current paper.

To improve the measurement accuracy of wood density and study the linear correlation between the drill feed resistance and wood density, a new micro drill instrument that can can simultaneously measure the rotation resistance and feed resistance of the drill needle was designed. The test wood samples included hardwood, softwood and conifer. The absolute dry density of each wood sample was measured. The drill resistance data was tested by using self-developed micro drill instrument and Resistogaph 650-SC. 4 linear models between drill resistance and the absolute dry density of wood . The results showed that: the statistical indicators of each model of the self-made micro drill resistance in-strument were better than the corresponding indicators of Resistogaph 650-SC; the coefficient of determination of the linear regression model between the feed resistance of the self-made micro drill resistance instrument and the absolute dry density of wood was 0.946; the statistical indicators of model including rotation resistance and feed resistance, were better than those of the model only including rotation resistance. Therefor, the design proposed in the article is reasonable, and increasing the feed resistance can improve the measurement accuracy of the micro drill resistance instrument for measuring wood density.

A semi-structured interview (SSI) is one of the essential tools in conduction qualitative research. This essay draws upon the pros and cons of applying semi-structured interviews (SSI) in the qualitative research method. Moreover, the challenges of SSI during the coronavirus pandemic are critically discussed to provide plausible recommendations.

The electronic structure of 7/9-AGNR superlattices with up to eight unit cells has been studied by means of state of the art Density Functional Theory (DFT) and also by two model Hamiltonians, the first one including only local interactions (Hubbard model, Hu) while the second one is extended to allow long-range Coulomb interactions (Pariser, Parr and Pople model, PPP). Both are solved within mean field approximation. At this approximation level, our calculations show that 7/9 interfaces are better described by spin non-polarized solutions than by spin-polarized wavefunctions. Consequently, both Hu and PPP Hamiltonians lead to electronic structures characterized by a gap at the Fermi level that diminishes as the size of the system increases. DFT results show similar trends although a detailed analysis of the density of states around the Fermi level shows quantitative differences with both Hu and PPP models. Before improving model Hamiltonians, we interpret the electronic structure obtained by DFT in terms of bands of topological states: topological states localized at the system edges and extended bulk topological states which interact between them due to the long-range Coulomb terms of Hamiltonian. After careful analysis of the interaction among topological sates, we find that the discrepancy between ab initio and model Hamiltonians can be resolved considering a screened long-range interaction that is implemented adding an exponential cutoff to the interaction term of PPP model. In this way, an adjusted cutoff distance λ = 2 allows a good recovery of DFT results. In view of this, we conclude that the correct description of the density of states around the Fermi level (Dirac point) needs the inclusion of long-range interactions well beyond Hubbard model but not completely unscreened as is the case for the PPP model.

Nano-titanium has excellent corrosion resistance and can be widely used in the field of corrosion resistant coatings. This paper introduces nano-weight titanium modified phenolic resin coatings and their anti-corrosion properties to explore the principle of nano-titanium modification and the mechanism of anti-corrosion to further develop more advanced corrosion resistant coatings. The article uses scanning electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy and UV-Vis spectrophotometer to characterise the morphology and structure of the nano-titanium modified phenolic resin coatings and to determine the corrosion resistance properties of the modified phenolic resin coatings. The results show that the 4% nano-titanium modified phenolic resin coating, nano-titanium powder and phenolic resin will maximize the dispersion and combination, and the structure is good; nano-titanium grafted on phenolic resin, the successful preparation of nano-titanium modified phenolic resin; modified nano-titanium added to improve the coating's ability of UV absorption. The corrosion resistance of the coating is much better than that of the unmodified phenolic resin coating.

It is important to add second- or third-phase materials to improve the physical, mechanical, and biodegradable properties of polypropylene (PP) nanocomposites. A unique hybrid bio-nanocomposite was fabricated using microparticle cellulose powder from wastepaper with a polypropylene (PP) polymeric matrix using a low-shear chaotic mixing method. A small amount (2-5%) of layered micro clay was also added to investigate the hybrid effect of nanocomposite fabrication on the mechanical properties. A low-shear chaotic melt mixing method induces the formation of nano cellulose structures and layered clay nanoparticles by via exfoliation. The nanoparticles were characterized using Fourier transform infrared (FTIR) spectroscopy. Mechanical properties such as the flexural strength (FS) and tensile strength (TS) were investigated using an Izod impact tester (IZ), and a dynamic mechanical testing analyzer (DMTA). Further, scanning electron microscopy (SEM) was used to observe the microstructure of the nanocomposite. In addition, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were conducted to investigate the crystallinity and degradation of the samples, respectively. The addition of wastepaper cellulose powder below 2.5 wt. % did not improve the mechanical properties, however, improvements were observed when more than 5wt.% wastepaper cellulose powder was added. With the addition of a small amount of nano-clay, the mechanical properties were significantly improved, and a synergistic effect could be noticed. The observed results were then compared with PP-clay nanocomposites used in automotive industries to replace cellulose nanocomposites. The application areas can also cover lead production in paper cups and vacuum foaming.

It is important to add second- or third-phase materials to improve the physical, mechanical, and biodegradable properties of polypropylene (PP) nanocomposites. A unique hybrid bio-nanocomposite was fabricated using microparticle cellulose powder from wastepaper with a polypropylene (PP) polymeric matrix using a low-shear chaotic mixing method. A small amount (2-5%) of layered micro clay was also added to investigate the hybrid effect of nanocomposite fabrication on the mechanical properties. A low-shear chaotic melt mixing method induces the formation of nano cellulose structures and layered clay nanoparticles by via exfoliation. The nanoparticles were characterized using Fourier transform infrared (FTIR) spectroscopy. Mechanical properties such as the flexural strength (FS) and tensile strength (TS) were investigated using an Izod impact tester (IZ), and a dynamic mechanical testing analyzer (DMTA). Further, scanning electron microscopy (SEM) was used to observe the microstructure of the nanocomposite. In addition, differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) were conducted to investigate the crystallinity and degradation of the samples, respectively. The addition of wastepaper cellulose powder below 2.5 wt. % did not improve the mechanical properties, however, improvements were observed when more than 5wt.% wastepaper cellulose powder was added. With the addition of a small amount of nano-clay, the mechanical properties were significantly improved, and a synergistic effect could be noticed. The observed results were then compared with PP-clay nanocomposites used in automotive industries to replace cellulose nanocomposites. The application areas can also cover lead production in paper cups and vacuum foaming.

In today’s world, it is the need of the hour to adopt new technology to sustain the production of the future. Nanotechnology is gaining popularity for its efficiency in various applied fields of science. In agriculture, nanomaterials have a huge impact on the efficiency of fertilizers pesticides, etc. As it requires very fewer quantities and has a negligible residual effect the environment is safe with the innovation of Nano fertilizer. Keeping this view into account an experimental Trial at a farmer’s field was carried out at Berui village in the Hooghly District of West Bengal during the winter (rabi) season of 2019 – 20 under the supervision of Berui Cooperative, KVK-Hooghly, BCKV, and IFFCO with nano-Urea, nano-Zn and nano-Cu using RBD design with 10 treatments and 3 replications. Experimental results revealed that the highest tuber yield was obtained in T-7 (50% N+100% P & K+ 2 spray of nano-Urea), and that was followed by T-10 (50% N + 100% P & K + 50% Zn + 1 spray each of Nano-Urea, Zn and Cu) and T-8 (100% N-P-K + 50% Zn + 2 spray of Nano-Zn). The performance of nano fertilizers, Nano- Urea, was quite promising and economically viable as compared to the 100% recommended dose with commercial fertilizers (RDF).

In this review, the following information describes the manifestation of sleep deprivation by human beings and its adverse effect on their health. Sleep deprivation has been demonstrated into namely two types known as REM sleep and NREM sleep affecting our health in so a problematic way that it is making our body immune to many diseases leading to lethal problems. Therefore, great research by many scientists has discovered that the turmeric “Curcuma longa” which is been used in every Indian kitchen since ancient times, has shown a remarkable effect on the problem caused by sleep deprivation but due to its poor solubility and low bioavailability drawn it into a great disadvantage. But the help of the study of nanotechnology and the evolution of curcumin into nano–curcumin made the possibility of the remarkable effect by making the curcumin more potent and enhancing its stability. Immunological changes due to sleep deprivation lead to Alzheimer’s disease, glioma, neuropathic pains, and many more. Therefore, this review has been summarized as it is been providing information related to curcumin and its affection for sleep deprivation.

Rubber-based composites are widely used especially in transportation. The goal of this paper is to study the mechanical properties of rubber-based composites of carbon black and Nano Aluminum trioxide additive (50 nm). Various percentage of carbon black was used (20,40, and 60 phr). The increase in Carbon black percentage shows an increase in mechanical properties of the composites (for 60 phr properties tensile test improve by 49%, for hardness resistance the improve was 21%, and for the wear test the composite improve by 22%). Various wetting percentage of nano Aluminum trioxide was used (1,1.5,2, and 2.5 %). Increasing the wetting percentage increase tensile strength (27%, hardness resistance increase by 28%, and wear resistance increase nonlinearly with a percentage reaching 70%). Selecting the optimal composition of the two fillers, then study different irradiances for it with the ultraviolet laser of moderately low energy after the vulcanization process. Post ultraviolet laser of (345 nm). Furthermore, laser vulcanization shows improvement in mechanical properties.

The thermal properties of novel nanomaterials play a significant role in determining the performance of the material in technological applications. Herein, direct measurement of the temperature diffusivity of cellulose nanocomposite films was carried out by the micro-contact method. Polymer films containing up to 2%wt. of nanocellulose were synthesised by a simple chemical process. Films of a high optical transmittance T ≈ 80 % (for a 200- μ m-thick film), which were up to 44% crystalline, were characterised. Two different modalities of temperature diffusivity based on: 1) a resistance change and 2) micro-thermocouple detected modulation of a heat wave, were used for the polymer films with cross-sections of ∼ 100 μ m thickness. Twice different in-plane α ‖ and out-of-plane α ⊥ temperature diffusivities were directly determined with high fidelity: α ‖ = 2 . 12 × 10 − 7 m 2 /s and α ⊥ = 1 . 13 × 10 − 7 m 2 /s. An amorphous polyethylene terephthalate (PET) fiber was measured for comparison α ‖ = 1 . 15 × 10 − 7 m 2 /s. This work provides an example of a direct contact measurement of thermal properties of nanocellulose composite films. The thermal diffusivity, which is usually high in strongly interconnected networks and crystals, was investigated for the first time in this composite.

Microbolometer is the most common uncooled infrared technique that allows to achieve 50mK-temperature resolution on the scene. However, this approach has to struggle with both the self-heating inherent to the resistive readout principle and the 1/f noise. We present an alternative approach that consists in using micro / nanoresonators vibrating according to a torsional mode, and whose resonant frequency changes with the incident IR-radiation. Dense arrays of such electromechanical structures were fabricated with a 12µm-pitch at low temperature allowing their integration on CMOS circuits according to a post-processing method. H-shape pixels with 9 µm-long nano-rods and a cross-section of 250 × 30 nm² were fabricated to provide large thermal responses, whose experimental measurements reached up to 1024 Hz/nW. These electromechanical resonators featured a noise equivalent power of 140pW for a response time of less than 1 ms. To our knowledge, these performance are unrivaled with such small dimensions. We also showed that a temperature sensitivity of 20 mK within 100ms-integration time is conceivable at a 12µm-pitch by co-integrating the resonators with their readout electronics and suggesting a new readout scheme. This sensitivity could be reached at short-term by depositing on top of the nano-rods a vanadium oxide layer having a phase-transition that could possibly enhance the thermal response by one order of magnitude.

The BRightest Target Explorer (BRITE) is the pioneering nanosatellite mission dedicated for photometric observations of the brightest stars in the sky. The BRITE CCD sensors are poorly shielded against extensive flux of energetic particles which constantly induce defects in the silicon lattice. In this paper we investigate the temporal evolution of the generation of the dark current in the BRITE CCDs over almost 4 years after launch. Utilizing several steps of image processing and employing normalization of the results it was possible to obtain useful information about the progress of thermal activity in the sensors. The outcomes show clear and consistent linear increase of induced damage despite the fact that only about 0.14% of CCD pixels were probed. By performing the analysis of temperature dependencies of the dark current, we identified the observed defects as phosphorus-vacancy (PV) pairs, which are common in proton irradiated CCD matrices. Moreover, the Meyer-Neldel empirical rule was confirmed in our dark current data, yielding E_MN=24.8 meV for proton-induced PV defects.

Europium (Eu)-doped fluorapatite (FA) nanorods has a similar biocompatibility with hydroxyapatite (HA) in terms, attracted much attention as cell imaging biomaterials due to their luminescent property. Here, we will discuss the new feature of europium doped fluorapatite (Eu-FA) nanorods as anticancer drug carrier. Eu-FA nanorods was prepared using a hydrothermal method. The morphology, crystal structure, fluorescence and composition are investigated. The specific crystal structure, enabling an effective loading of drug molecules. Doxorubicin (DOX), used as an anticancer model drug, was shown to be effectively loaded onto the surface of the nanorods. The DOX release was fairly pH-dependent, occurring more rapidly at pH 5.5 than pH 7.4 was observed. The intracellular penetration of the DOX-loaded Eu-FA nanorods (Eu-FA/DOX) can be imaged in situ due to the self-fluorescence property. Treatment of melanoma A375 cells with Eu-FA/DOX elicited a more effective apoptosis rate than direct DOX treatment. Overall, Eu-FA show great promise for tracking and treating tumor, may potentially useful as a multifunctional carrier system to effectively load and sustainably deliver drugs.

Using structured light to drive colloidal motors, due to its advantages of remote manipulation, energy tunability, programmability, and controllability of spatiotemporal distribution, has been attracting much attention in the fields of targeted drug delivery, environmental control, chemical agent detection, and smart device design. Here, we focus on studying the group control of colloidal made from a photo-responsive organic polymer molecule NO-COP (N,O-Covalent organic polymer). These colloidal motors mainly respond to the light intensity patterns. We chose a digital micromirror device (DMD) to modulate the structured light field shining on the sample, by considering its merit of fast refreshing speed, good programmability, and high-power threshold. It is found that under ultraviolet or green light modulation, such colloidal motors exhibit various group behaviors including group diffusion, group patterning, and group migration. The qualitative interpretation is also provided for these observations.

Recently, a paper was written to reformulate and strengthen the theory of semi-structured complex numbers H (a new number set invented to enable division by zero). Whilst the paper had profound results, the application of this number set in many areas of engineering and science has not been fully explored. Consequently, the aim of this paper was to establish the number set H as a useful mathematical tool by providing an amalgam of results arising from its application in several areas of engineering and science. In the process, this paper makes four major contributions: these are (1) determining the product of the gradients of a horizontal and vertical line; (2) developing new Euler formulas relating exponential, trigonometric and hyperbolic functions in the 3D semi-structured complex number Euclidean space; (3) establishing semi-structured complex numbers as a better extension of the complex number set than quaternions; (4) resolving singularities that may arise in engineering and science equations (because of division by zero) to develop reasonable conclusions in the absence of experimental data. These results and their applications provide a firm foundation to advance the number set H as a useful mathematical tool.

In this work modeling and analysis of an integrated opto-fluidic sensor, with a focus on achievement of single mode optical confinement and continuous flow of micro particles in the microfluidic channel for Lab-on-a Chip (LOC) sensing application is presented. This sensor consists of integrated optical waveguides, microfluidic channel among other integrated optical components. A continuous flow of micro particles in a narrow fluidic channel is achieved by maintaining the two sealed chambers at different temperatures and by maintaining a constant pressure of 1Pa at the centroid of narrow fluidic channel geometry. The analysis of silicon on insulator (SOI) integrated optical waveguide at an infrared wavelength of 1550nm for single mode sensing operation is presented. The optical loss is found to be 0.0005719dB/cm with an effective index of 2.2963. The model presented in this work can be effectively used to detect the nature of micro particles and continuous monitoring of pathological parameters for sensing applications.

Nowadays, it is highly desired to develop highly active and humidity resistive ozone decomposition catalyst to eliminate the ozone contaminant, one of the primary pollutants in air. In this work, a series of Cu2S hollow structured materials are rapidly synthesized using different structured Cu2O templates. The Cu2S from porous Cu2O shows the highest ozone catalytic decomposition efficiency of >95% to 400 ppm ozone with a weight hourly space velocity of 480,000 cm3g-1h-1 in dry air. Importantly, the conversion still keeps >85% in a high relative humidity of 90%. The mechanism is explored by diffusive reflectance infrared spectroscopy which shows the decomposition intermediate of O22-, and the X-ray photoelectron spectroscopy reveals the dual active site of both Cu and S. All these results show the effective decomposition of ozone by Cu2S especially in harsh environments, promising for active ozone elimination.

In the realm of artificial intelligence, knowledge graphs have become a fascinating area of research. Relationships between entities are depicted through a structural framework in knowledge graphs. In this paper, we propose to build a domain-specific medicine dictionary (DSMD) based on the principles of knowledge graphs. Our dictionary is composed of structured triples, where each entity is defined as a concept, and these concepts are interconnected through relationships. This comprehensive dictionary boasts more than 348,000 triples, encompassing over 20,000 medicine brands and 1,500 generic medicines. It offers a groundbreaking approach to storing and accessing medical data. Our dictionary facilitates various functionalities, including medicine brand information extraction, brand-specific queries, as well as queries involving two words or question answering. We anticipate that our dictionary will serve a broad spectrum of users, catering to both human users, such as diverse range of healthcare professionals as well as AI applications.

The proton exchange membrane fuel cell (PEMFC) is a critical and essential component of zero-emission electro-hydrogen generators. An accurate prediction of its performance is important for optimal operation management and preventive maintenance of these generators. However, the prediction is not simple because the PEMFCs have complex electrochemical reactions with multiple nonlinear relations between operating variables as inputs and voltage as output. In this paper, we propose an efficient prediction approach based on XGBRegressor and Tree-structured Parzen Estimator. In addition, to better select relevant features, Kernel Principal Component Analysis and Mutual Information are jointly used. The proposed approach allows consideration of the dynamic operating conditions of the PEMFC. To test and validate the robustness of the proposed approach, a real data-set of ten PEMFCs was considered. Furthermore, a comparison study with traditional machine learning models, such as artificial neural networks and support vector machine regression, was investigated. The obtained results confirm that our model outperforms the considered traditionel machine learning models.

Semi-structured complex numbers H was a number set developed to enable division by zero in ordinary algebraic equations. Its utility has been shown in mathematics and engineering. However, very little has been done to show its usefulness in computer science. Consequently, the aim of this paper was to show the utility of semi-structured complex numbers in computer science by developing a division by zero calculator. First two computer programs were written, one for a standard (STD) calculator and the other for a division by zero (DBZ) calculator. The programs were fed 20000 randomly generated arithmetic equations of varying lengths and the space and time complexity associated with processing these equations were measured and compared to determine the efficiency of each calculator. In the process, three major contributions were made: (1) A representation for semi-structured complex numbers that enables it to be easily used by a computer was developed; (2) It was demonstrated that the DBZ calculator outperforms the STD calculator in terms of efficiency; and, (3) It was shown that the number set H reduced the amount of error handling required to run a computer program. These results provide a firm foundation to advance the number set as a useful tool in computer science.

Social media has become part and parcel of the world of today. These days, it’s still the most talked about thing. It cannot be overlooked because it plays a key role in our business functions such as marketing and advertising. Social Media is all about collaboration on files, ideas and projects that help users and stakeholders to successfully complete the project. It influences how people communicate, develop relationship, build trust, increase transparency and provide cultural context. The fundamental aim of this research is to investigate the capacity for project management in social media. This paper explains how social media is used for project management knowledge areas and process groups. Also this research aims to identify SM tools that can be suitable for project management processes. Two studies Delphi Study of three rounds and structured case study interview are used to investigate the impact on the performance of the project team and process robustness. These studies support social media use by accessing the contribution to relationship building, trusts, coordination and cohesion.

For several millennia, doctors and healers used therapeutic ingredients extracted from minerals, plants, and animals. Among the active remedies derived from animals, the placenta was among the most popular ones. The use of placenta-based remedies has retained its significance in our time. The placenta-based therapeutics are indicated for stimulating immunity, wound healing, reduction of skin pigmentation, treatment of various patients suffering from gynecological disorders, etc. By the beginning of the 21st century, the majority of specific functions and chemical ingredients of the placenta were identified and described. However, only now active proteins and peptides with molecular weight of about ten kDa were revealed. Presumably, they play an essential role during the therapeutic application of placental extract. Hopefully, this discovery will start a new era in the research and clinical application of organotherapeutic remedies, including placenta.

This study introduces an innovative integration of hyperbolic metamaterials (HMMs) and photonic crystals (PtCs), each possessing unique dispersion properties that effectively manipulate the propagation of light. We present a PtC waveguide consisting of arrays of HMM nanorods, denoted as HMM PtCs. This waveguide configuration enables the realization of a high figure of merit (FOM) nano-sensor. By modifying the refractive indices of the surrounding materials, the PtC waveguide exhibits alterations in absorption and transmission, allowing for the detection of temperature, pressure, and material variations. Numerical methods were employed to demonstrate the remarkable efficiency of this proposed system, achieving a sensitivity of 324.16 nm/RIU (refractive index unit) and an impressive FOM of 469.58 RIU−1. These results signify a substantial improvement over surface plasmonic sensors, which typically exhibit limited FOMs. As a consequence, the HMM PtC waveguide sensor emerges as an exceptionally appealing option for photonic sensing applications. The proposed HMM PtC waveguide holds vast potential across diverse fields, including biology, medicine, and clinics, representing an exciting advancement for both industry and scientific research.

Current spacecraft mass are mostly fuel, this is dictated by the lack of fueling stations in space and also by the Tsiolkovsky rocket equation which defines the mass ratio needed to escape earths gravity. The Tsiolkovsky rocket equation gives a relationship between the mass ratio and the final velocity in multiples of the exhaust speed, and dictates a high mass ration for current exhaust speeds. A relativistic motor exchanging momentum and energy with the electromagnetic field may mitigate such considerations, enabling efficient interplanetary travel. In this paper we will discuss the advantages and challenges of this novel mover for space transportation.

This study reports the preparation of silica and nano-fructosome encapsulated Candida antarctica lipase B particles (CalB@NF@SiO2) and demonstration of their enzymatic hydrolysis and acylation. CalB@NF@SiO2 particles were prepared as a function of TEOS concentration (3-100 mM). Their mean particle size was 185 nm by TEM. Enzymatic hydrolysis was performed to compare catalytic efficiencies of CalB@NF and CalB@NF@SiO2. Catalytic constants (Km, Vmax, and Kcat) of CalB@NF and CalB@NF@SiO2 were calculated with Michaelis-Menten equation and Line-weaver Burk plot. Optimal stability of CalB@NF@SiO2 was found at pH 8 and temperature of 35 ℃. Moreover, CalB@NF@SiO2 particles were reused for seven cycles to evaluate their reusability. In addition, enzymatic synthesis of benzyl benzoate was demonstrated by an acylation reaction with benzoic anhydride. The efficiency of CalB@NF@SiO2 for converting benzoic anhydride to benzyl benzoate by the acylation reaction was 97%, indicating that benzoic anhydride was almost completely converted to benzyl benzoate. Consequently, CalB@NF@SiO2 particles are better than CalB@NF particles for enzymatic synthesis. In addition, they are reusable with high stability at optimal pH and temperature.

Advanced Nano structural hard coatings are thin materials films that range in thickness from a few nanometers to a few micrometers and are applied to different surfaces to increase their hardness and wear resistance. Physical vapor deposition (PVD) or chemical vapor deposition (CVD) methods are frequently used to deposit these coatings. These coating’s distinctive characteristics result from their microstructure, which is made up of material columns or grains with a diameter of only a few nanometers. Increased hardness, higher wear resistance, and improved tribological properties result from these short dimensions. In applications with significant wear and/or high contact pressures, such as cutting tools, bearings, and engine parts, the usage of sophisticated Nano structural hard coatings is crucial. Advanced Nano structural hard coatings include, 1. Amorphous carbon coatings with high hardness, low friction, and exceptional wear resistance are known as diamond-like carbon (DLC) coatings. DLC coatings are frequently used in a variety of industries, including the automotive, aerospace, and biomedical ones. 2. Coatings made of titanium nitride (TiN): These metallic coatings have high hardness and wear resistance. Cutting tool, machining, and aerospace industries frequently use TiN coatings. 3. Chromium nitride (CrN) coatings: These coatings have great corrosion resistance, good wear resistance, and high hardness. Cutting tools, gears, and bearings are just a few of the objects that use CrN coatings. 4. Tungsten carbide (WC) coatings: These coatings, which have a high degree of hardness and wear resistance, are frequently employed in cutting tools and other applications that require wear resistance. Advanced Nano structural hard coatings provide many advantages over conventional coatings, including better hardness, increased wear resistance, and improved tribological qualities. The automotive, aerospace, and biomedical industries are just a few that could use these coatings. In this paper the author will explain about the design synthesis and applications of advanced Nano structural hard coating in aerospace and automotive applications.

Reaction of 2-mercapto-3-phenylquinazolin-4(3H)-one (MPQ) with both 4-vinyl benzyl chloride and allyl bromide furnished the reactive heterocyclic monomers 3-phenyl-2-((4-vinylbenzyl) thio) quinazolin-4(3H)-one (PVTQ) and 2-(allylthio)-3-phenylquinazolin-4(3H)-one (APQ), respectively. Copolymerization of PVTQ monomer with styrene and methyl methacrylate in the presence of 2,2′-azobisisobutyronitrile (AIBN) afforded the copolymers PS-co-PPVTQ and PMMA-co-PPVTQ, respectively. Similarly, copolymerization of monomer APQ with styrene and methyl methacrylate (MMA) afforded the copolymers PS-co-PAPQ and PMMA-co-PAPQ, respectively. The resulted copolymers were characterized by using FT-IR, 1H-NMR and GPC techniques. Silver nanocomposites of PS, PMMA, PS-co-PPVTQ, PMMA-co-PPVTQ, PS-co-PAPQ and PMMA-co-PAPQ were synthesized by the addition of silver nitrate into the polymer solution. The reduction of silver ions into silver nanoparticles was performed in DMF and water. Thermogravimetric (TGA) analysis was used to determine the thermal stability of the copolymers and their silver nanocomposites. The X-ray diffraction (XRD) analysis indicated the amorphous structures of the co-polymers and confirmed the formation of silver nanoparticles. The antitumor and antibacterial activities were screened for the copolymers and enhanced by the formation of their silver nanocomposites. In vivo antitumor activity in Ehrlich Ascitic Carcinoma (EAC) mice model showed that PS-co-PPVTQ/Ag NPs, PMMA-co-PPVTQ/Ag NPs, and PMMA-co-PAPQ/Ag NPs displayed promising inhibitory effects against EAC and induce apoptosis against MCF-7 cells.

Natural products endowed of biological activity represent a primary source of commodities ranging from nutrition to therapeutic agents, as well as cosmetic tools, and recreational principles. These natural means have been used by mankind since centuries if not millennia. They are commonly used all over the world and socio-economical contexts but are particularly attractive in disadvantaged area or economically emerging situations all over the world. This is very likely due to the relatively easy recovery of these bioactive principles from the environment, to the low if any cost as well as ease of administration and to the general popular compliance concerning their consumption/ingestion. In this concise review, we focus on some popular bioactive principles of botanical origin which find a wide use in the Madagascan populations. But, due to space limitations only some most common and largely diffused principles in this country are considered. Finally, a possible nanotechnological administration is discussed in the case where a potential therapeutic usage is envisaged.

Nowadays, we can observe a worldwide trend towards the development of synthetic biomaterials. Numerous researches have been carried out in order to better understand the cellular behavior involved in the inflammation and bone healing processes related to living tissues. The aim of this study is to evaluate the tissue behavior of two different types of biomaterials: synthetic nano-hydroxyapatite / beta-tricalcium phosphate and hydroxyapatite in non-critical bone defects in rat calvaria. Twenty four rats underwent surgery in which two 3 mm defects in each cavity were performed. The rats were divided into 2 groups: Group 1, using xenogen hydroxyapatite (Bio oss ™); Group 2, using synthetic nano-hydroxyapatite / beta-tricalcium phosphate (Blue Bone ™). Sixty days after the surgery, the calvaria bone defect was filled with biomaterial, the animals were sacrificed and marked with Masson's trichrome and PAS staining, and immunohistochemistry (TNF-α, MMP-9) and electron microscopy analyzes were performed. Histomorphometric analysis indicates a greater presence in the protein matrix in Group 2, in addition to higher levels of TNF-α, MMP-9. The ultrastructural analysis shows an association of material with fibroblasts in the tissue regeneration stage. Paired statistical data indicates that Blue Bone ™ can improve bone formation / remodeling when compared to biomaterials of xenogenous origin.

A highly dirt resistant paint for building facades without chemicals harmful to nature and environment, is developed which resolves the unattractive disfigurement of building walls caused by dirt. The experimentation is scientifically and statistically planned with the aid of computer programming. It consists of a sequence of phases which include the selection of appropriate raw materials, adopting of Basic Language computer programming to generate a target population of paint formulations. The average PVC percentage is computed using theory and found to be 54.98% for the target population of 543143 paint formulations hence verifies the literature results. Experimentation and statistical analysis are performed to compare the classical conventional agitator with latest lab equipment like Nano mill and it is concluded that Nano mill performs better on the average than conventional agitator in preparation of paint formulations. Hence the sample of paint formulations is prepared on Nano mill and tested in laboratory using advanced available technology for the analysis and comparison of paint properties to determine the best paint formulation. The results are analyzed using Analysis Of Variance Technique (ANOVA) and it is concluded that the paint formulation named “O3” has the highest dirt resistance on the average. The final selected formula O3 is compared with three other competitor paints in market under natural environment for a period of almost one year. A regression model is also constructed to study the effect of environmental factors like time, temperature and humidity on dirt resistance of paints. It is found that O3 formulation is the best environment friendly which performs equally well with one competitor paint and has higher dirt resistance than two other competitor paint formulations containing harmful chemicals. The regression model of dirt resistance on variables including time, temperature and humidity shows that these factors are significantly affecting the dirt resistance of a given paint at 5% level of significance. 95.34% variation in the dirt resistance of a given paint is due to and explained by the given factors. The regression model is useful to predict the average dirt resistance of a given paint with a certain level of confidence. The project exemplifies the work of an applied research from conceptualization to successful commercialization for the paint industry.

In this work, pure TiO₂ and nano-magnetic of Fe₃O₄/TiO₂ were synthesized for degradation of 2,4-dichlorophenol (2, 4-DCP) as an organic pollutant. A range of analytical techniques including XRD, DRS, FESEM, and VSM were employed to reveal the crystal structure, morphology and property of the nanocomposite. The XRD results showed the prepared samples including 100% anatase phase. We obtained the band gap energy 2.9 and 2.8 eV for pure TiO₂ and Fe₃O₄/TiO₂ respectively. VSM results demonstrate that easy, fast separation and redispersion of Fe₃O₄/TiO₂ sample can be realized. We obtained 62% and 31% degradation of 2,4-DCP in the presence of Fe₃O₄/TiO₂ and pure TiO₂ under visible light respectively.

A compact 2-DOF (two degrees of freedom) piezoelectric-driven platform for 3D cellular bio-assembly systems has been proposed based on “Z-shaped” flexure hinges. Multiple linear motions with high resolution both in x and y directions are achieved. The “Z-shaped” flexure hinges and the parallel-six-connecting-rods structure are utilized to obtain the lowest working stress while compared with other types of flexure hinges. In order to achieve the optimized structure, matrix-based compliance modeling (MCM) method and finite element method (FEM) are used to evaluate both the static and dynamic performances of the proposed 2-DOF piezoelectric-driven platform. Experimental results indicate that the maximum motion displacements for x stage and y stage are lx=17.65 μm and ly=15.45 μm, respectively. The step response time for x stage and y stage are tx=1.7 ms and ty =1.6 ms, respectively.

The present study aims at deposition of zinc phosphate coatings with the incorporation of nano Titanium dioxide particles by chemical phosphating method. Zinc phosphate coatings were developed on low carbon steel by using nano TiO2 in the standard phosphating bath. The Coated low carbon steel samples were assessed for corrosion studies using electrochemical impedance spectroscopy and potentiodynamic polarisation techniques in 3.5% NaCl solution. Chemical composition of the coatings was analysed by energy dispersive X-ray spectroscopy (EDX). Significant variations in the coating weight, porosity and corrosion resistance were observed with the addition of nano TiO2 in the phosphating bath. Corrosion rate of nano TiO2 incorporated chemical phosphate coated samples was found to be 3.5 mpy which was 4 times less than the bare uncoated low carbon steel (~14 mpy). Electrochemical impedance spectroscopy studies revels in the reduction of porosity in nano TiO2 phosphate coated samples. It was found that nano TiO2 particles in the phosphating solution yielded phosphate coatings of higher coating weight, greater surface coverage and enhanced corrosion resistance than the normal zinc phosphate coatings (developed using normal phosphating bath).

Grape dehydration is practiced widely in the food industry with large yields of sultanas produced globally. This paper proposes an investigation into grape microstructure changes as it is dried by imaging specimens at intervals during dehydration at two temperatures using scanning electron microscopy. Detailed images of the microstructure were obtained, and a unique image processing algorithm was developed to quantitatively analyse the properties of this microstructure. Two main methods were developed to obtain the complex boundaries of cells present in the grape tissue in over 36 SEM images. Segmentation of the binary image using an adapted watershed function obtained the most consistent and accurate morphological shape. This was compared to a secondary method which used Canny’s edge detection function, morphological closing and skeletonizing to outlines the cellular microstructure. MATLAB was utilised to convert these boundaries into measurable areas so that quantitative data on average cell area, perimeter and cell axis lengths was acquired. It was found that over drying time cell area and perimeter reduced as expected. Some variability in the data was clear due to only single samples being analysed for each temperature and time combination. The development of automatic image processing techniques will enable quantitative data to be extracted from these images. Trends in cell perimeter, diameter and shape will be used to demonstrate relationships between morphological structure, drying temperature, and duration.

With the increased emphasis on competition in academic settings, anxiety is becoming more common, which inevitably has some impact on students’ learning process and result. This study aimed to explore how competition-induced anxiety influences the subjective cognitive load (SCL), attention level and test score. Meanwhile, we investigated the mediating role of the behavioral inhibition system/behavioral activation system (BIS/BAS) in those processes. A total of 101 college students were recruited in Study 1 to learn five micro-lectures from massive open online courses (MOOC) under with and without competitive conditions. The results showed that participants’ state anxiety (SA) scores were higher after the experiment, participants in the competition condition had higher test scores, and the relationship between SA/ trait anxiety (TA) and SCL could be mediated by the BIS. To obtain more objective data on learning processes (attention levels), we conducted Study 2, which collected behavioral and EEG data from 42 college students during the online learning. The results showed that the competition group had higher SA, lower attention levels, and worse test scores, and the relationship between SA/TA and attention levels could be mediated through the BIS. The present study not only expands previous research by finding that BIS functioning plays an important role in the effects of anxiety on cognitive load and attention, but also offers implications for using competitive strategies to motivate students according to their aptitude.

In our day-to-day life, Lie detection has a significant concern. We human beings are very much inaccurate while detecting the liars and We believe in what we are told. Lie detection is important in today’s life, because Concealing the information or faking it can sometimes take you to huge problems. In any areas like airport management[2], criminal investigations, counterterrorism, etc this concept has great importance. It is an evergreen challenging and changing topic. This paper presents the common technique which was followed up till now and why it was not considered effective and a review of Robust solutions to detection of deception. People generally do not[3] always believe on what someone says but also try to visualize their facial expressions. While in Robust solution these facial micro-expressions are identified, which are tiny, natural expressions seen on the individual’s face, when they try to conceal or suppress emotions. In addition, the article also provides the year-wise assessment and analysis of research articles published in the area of Lie detection from 2011 to 2022. In the end, our proposed framework for lie detection system is also presented. This paper cover up current issues as well as challenges that could be helpful to resolve in future research works. The review paper closes up by supporting future directions.

Abstract: Microstructural and mechanical properties of the eutectic Sn58Bi and micro-alloyed Sn57.6Bi0.4Ag solder alloys were compared. With the addition of Ag micro-alloy, the tensile strength was improved and this is attributed to a combination of microstructure refinement and an Ag3Sn precipitation hardening mechanism. However, ductility is slightly deteriorated due to the brittle nature of the Ag3Sn intermetallic compounds (IMCs). Additionally, a board level reliability study of Ag micro-alloyed Sn58Bi solder joints produced utilising a surface-mount technology (SMT) process, were assessed under accelerated temperature cycling (ATC) conditions. Results reveal that micro-alloyed Sn57.6Bi0.4Ag has a higher characteristic lifetime with a narrower failure distribution. This enhanced reliability corresponds with improved bulk mechanical properties. It is postulated that Ag3Sn IMCs are located at the Sn-Bi phase boundaries and suppress the solder microstructure from coarsening during the temperature cycling, hereby extending the time to failure.

The tissue micro environment or milieu consists of a highly dynamic population of cellular and non-cellular components which constitute a complex regulatory network aimed at maintaining the organ homeostasis. In the modern medicine the discovery of miRNAs is undoubtedly a promising field of research and they are essential in orchestrating immune system logic and their release in the gut micro milieu can directly affect bacterial gene expression. Here, we briefly review the role of microRNAs, focuses on their role on immune system components in physiological and pathophysiological gut micro milieu.

One of the most important objectives of the studies worldwide is to improve the performance of automotive engines to reduce fuel consumption and environmental pollution. Accordingly, the principal motivation of this research study is improving the tribological behavior of the piston ring/cylinder liner interfaces as a promising and straightforward approach in automotive fuel economy and increasing engine durability using Al₂O₃ and TiO₂ nanomaterials as smart nano-lubricant additives that adapted to different operating conditions by replenishing mechanisms anti-friction and anti-wear in automotive engines.

Titanium micro-scale topography results in excellent osteoconductivity and bone-implant integration. However, the biological effects of sub-micron topography are unknown. We compared osteoblastic phenotypes and in vivo bone and implant integration abilities between titanium surfaces with micro- (1–5 µm) and sub-micro-scale (0.1–0.5 µm) topographies and machined titanium. Average roughness was 12.5 ± 0.65 nm, 123 ± 6.15 nm, and 24 ± 1.2 nm for machined, micro-rough, and sub-micro-rough surfaces, respectively. The micro-rough surface showed the fewest cells attaching during the initial stage and the lowest proliferation. Calcium deposition and expression of osteoblastic genes were highest on the sub-micro-rough surface and lowest on the machined surface. Bone-to-implant integration was strongest for the micro-rough surface, consistent with it having the greatest ability to retain cells in vitro. Thus, the biological effects of titanium surfaces are not necessarily proportional to the degree of roughness in osteoblastic cultures or in vivo. Sub-micro-rough titanium ameliorates the disadvantage of micro-rough titanium by restoring cell attachment and proliferation and enhances the rate of osteoblastic differentiation over that of micro-rough titanium; however, bone integration and the ability to retain cells are compromised due to its lower interfacial mechanical locking compared to that of micro-rough titanium.

This study demonstrates the efficacy of structured pruning and architectural fine-tuning on the YOLOv7-tiny model for eye state detection, emphasizing optimization for real-time applications. Structured pruning significantly reduced the model's complexity and storage size while maintaining high detection accuracy, as evidenced by stable precision, recall, and mAP@.5 metrics across iterations. Further fine-tuning adjusted the model's width and depth, optimizing efficiency and processing speed without compromising performance. These optimizations yielded YOLOv7-tiny variants that are both computationally efficient and accurate, suitable for resource-constrained environments. The findings highlight the critical role of model optimization in deploying effective neural networks for specific detection tasks in real-time scenarios.

Spatial biology is a rapidly growing research field which focuses on the transcriptomic or proteomic profiling of single cells within tissues with preserved spatial information. Imaging-based spatial transcriptomics uses epifluorescence microscopy, which has shown remarkable results for identification of multiple targets in situ. Nonetheless, the number of genes that can be reliably visualized is limited by the diffraction of light. Here, we investigate the effect of structured illumination (SIM), a super-resolution microscopy approach, over the performance of single gene transcript detection in spatial transcriptomics experiments. We performed direct mRNA-targeted hybridization in situ sequencing for multiple genes in mouse coronal brain tissue sections. We evaluated spot detection performance in widefield and confocal images versus those with SIM in combination with 20X, 25X and 60X objectives. In general, SIM increases the detection efficiency of gene transcripts spots compared to widefield and confocal modes. For each case, the specific fold increase in localizations is dependent on gene transcripts density and the numerical aperture of the objective used, which showed to play an important role especially for densely clustered spots. Taken together, our results suggest that SIM has the capacity to improve spot detection and overall data quality in spatial transcriptomics.

In this study, the impact of the addition of high-aspect-ratio nano-ettringite to photocurable epoxy acrylate resin was explored, with a specific focus on the changes observed in viscosity, shrinkage, tensile strength, and elongation at the break of composites formed. Herein, the nano-ettringite samples were modified using KH-570. The 3 wt% or 6 wt% KH-570-modified and unmodified nano-ettringite were dispersed into the resin by ultrasonic treatment in conjunction with mechanical stirring. The grafting effects of nano-ettringite onto KH-570 were analyzed through scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric (TG) analysis, and Fourier transform infrared spectroscopy (FTIR). The results demonstrate that increased dosages of unmodified and modified nano-ettringite led to increased viscosity of the composite while reducing shrinkage. At the same dosage, the photocurable resin with modified nano-ettringite demonstrated a lower shrinkage and a higher tensile strength. Notably, when the amount of modified nano-ettringite was 3 wt%, the highest tensile strength of the composite was 64.61 MPa, presenting a 72.57% increase compared to the blank sample. Furthermore, the incorporation of modified nano-ettringite as a filler provides a new perspective for improving the performance of photocurable epoxy acrylate resin composites.

A new method is proposed for performance assessment of lubricating compositions based on industrial lubricants that contain nano-additives of different chemical composition for higher wear resistance of heavy-loaded steel friction pairs. The method is based on the joint analysis of the experimental data on the wear kinetics, change of the relative hardness, and damage in the surface layers of the metal of friction pairs. The level of structural damage to the materials in the contact zone is determined by using the statistical parameters of dispersion of the hardness values. The paper investigates the known experimental results of assessment of the level of damage to structural materials of various grades under the conditions of long-term, cyclic, static loading, and lubricated friction. It is demonstrated that the structural changes occurring in the materials during loading correlate to the changes in the statistical dispersion characteristics of hardness measurement results. Experimental substantiation of the method is carried out for steel friction pairs using lubricating compositions based on industrial oil Greaseline Lithium BIO Rail 000 by AIMOL and nano-additives of copper of M2 grade, magnesium alloy of MA2 grade, aluminum alloy of Al-Mg system, graphite of medium carbon steel grades, i.e. rail and industrial. Under system of indicators presented in the paper, the highest efficiency in terms of increase in the wear resistance of steel friction pairs is demonstrated by the lubricating composition based on industrial lubricant with the additive of nano-powder made of rail steel, as it provided the optimum value of friction coefficient, minimum damage and wear of friction surface.

Some of Iran's gas resources are known as sour gas because one of the major by-products of this gas is water. In fact, natural gas is combined with water vapor in underground reservoirs. In some areas, the amount of water vapor in natural gas is so high that it can be used as a source of drinking water. However, it should be noted that water vapor in natural gas may exacerbate corrosion in pipes and industrial equipment, and the combustion of more natural gas produces high temperatures that can lead to the production of nitrogen oxides (NOx), which They are the cause of air pollution. This is while the processed gas has a standard percentage composition in which the amount of water has the lowest position. The removal of moisture from natural gas is due to the need to prevent the reduction of the calorific value of the gas and also to purify the gas in order to achieve the necessary standards for delivering gas to petrochemicals, industries and domestic uses. The main goal of this research is to investigate the influencing parameters on zeolite TiO2 nanocomposite membranes in order to absorb moisture from gas. For this reason, with the construction of a TiZ-V membrane as a standard membrane, the result of the initial evaluation of a suitable membrane for gas dehumidification was made, and this membrane was placed as a standard for measuring the effect of the manufacturing parameters in a way that in each stage of membrane construction It was found that it was different from standard TiZ-V membrane only in terms of one parameter. This type of investigation made it possible to determine the effect of various effective parameters in membrane construction on efficiency. The findings showed that increasing the concentration of SiO2 has the greatest effect on increasing the water flux of the membrane. According to the other findings of this study, the effect of increasing the reaction time of the vapor phase carrier has been to reduce the process of paternity selectivity loss at higher pressures. Although due to the safety limitation of the equipment to measure the efficiency of the membrane at pressures higher than 7 bar, this measurement was not carried out, but charts were presented regarding the state of the water in the water, which were a measure of the superiority of the water in the water in comparison to the gas in the water, which is the higher water in the water It is an indicator of the appropriateness of the membrane's efficiency at its corresponding pressure, so that the examination of the difference between these two graphs shows the possibility of using the membrane at higher pressures

Nanomaterials exhibit novel properties and profound attributes as an additive in asphalt binder modification. However, the application of nano-silica in asphalt binders and mixture modification is still limited and further research is required. Along these lines, in this work, nano-silica with a content from 2% to 8% and an increment of 2% were utilized in modifying the bitumen binder type C320, which is considered the most conventional type of bitumen used in Western Australia road asphalt mixtures. Various tests were performed to assess their properties including dynamic shear rheometer, penetration, softening point, and multiple stress creep recovery (MSCR) test. The extracted results revealed an increase in the strength and stiffness properties by lowering the penetration, improving the softening point, and increasing the complex shear modulus of all nano-silica modified bitumen samples. Interestingly, a relatively big content of nano-silica leads to a higher rutting resistance. Nevertheless, the rutting resistance was affected by the size of the nano-silica coated with the silane coupling agent. The ideal sample of nano-silica modified C320 was determined as NS-15nm (NS-A), which can improve the rutting resistance. Nevertheless, the rutting resistance of the modified asphalt mixtures needs to be further investigated in the future to elaborate on the impact of nano-silica as modified binders on the mechanical properties of Australian asphalt mixtures.

In the current study nanocellulose was isolated from walnut shell using mechanical and chemical methods. This study highlights the particle size, morphology and these methods’ efficiency in nano structure extraction. The difference between morphology and size of the particles (of the both extracted methods) were investigated by field emission scanning electron microscopy (FESEM). Walnut shell is an agro-waste material with source of lignin and cellulose. Ball mill-ing with different times, in the presence and absence of additive and acid hydrolysis were used as mechanical and chemical methods, respectively. The result showed mechanical method is unable to extract nanoparticle and just reshape the walnut shell. Milling time were also found important in morphology of fiber extracted. FE-SEM images represented that structure mean diameter of using ball mill was 1± 5 μm while hydrolysis acid method extract nano particle with mean diameter of 40± 20 nm.

In this study, grit blasting pretreatment was used to improve the adhesion and corrosion resistance and microhardness of Ni-W/SiC nanocomposite coatings fabricated using conventional electrodeposition technique. Prior to deposition, grit blasting and polishing (more commonly used) pretreatment were used to prepare the surface of the substrate and the 3D morphology of the pretreated substrates was characterized using laser scanning confocal microscopy. The coatings surface and the cross section morphology were analyzed using scanning electron microscopy (SEM). The chemical composition, crystalline structure, microhardness, adhesion, and the corrosion behavior of the deposited coatings were characterized using energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), microhardness tester, scratch tester and electrochemical workstation, respectively. The results indicated that the grit blasting and SiC addition, improved the microhardness, adhesion and corrosion resistance. The Ni-W-SiC nanocomposites pretreated by grit blasting exhibited the best adhesion strength, up to 36.5 ± 0.75 N. Its hardness was the highest and increased up to 673 ± 5.47Hv and its corrosion resistance was the highest compared to the one pretreated by polishing.

The present study examines the effect of SiO2 nano-additives on the performance and emission characteristics of a diesel engine fuelled with soybean biodiesel. Soybean biofuel was prepared using the transesterification process. Nano-additives characterisations were done using different tests such as FESEM, XRD, EDS, etc., to study the morphology of nano-additives. For proper blending of nano-additives with biodiesel, the ultrasonication process was used. Surfactant was used for the stabilisation of nano-additives. After making all the combinations of nano fuel blends, physicochemical properties were measured as per ASTM standards. Performance and emissions readings were taken at different load conditions. It was found that with the addition of SiO2 nano-additives, brake thermal efficiency (BTE) and brake specific fuel consumption (BSFC) was increased by 3.48-6.39% and 5.81-9.88%, respectively. Significant reduction of CO, CO2, NOx, and smoke emissions were also observed compared to baseline fule due to better combustion efficiency with the use of SiO2 nano-additive.

Recently, a paper was written to establish semi-structured complex numbers ℍ (a new number set invented to enable division by zero) as a useful mathematical tool providing novel results from its application in engineering and science. Whilst the paper was a milestone, the application of this number set to quantum and classical physics had not been fully explored. Consequently, the aim of this research was to use semi-structured complex numbers to develop a new mathematical model for the mass of an object and in course unite classical and quantum physics in a simple yet effective manner. As its major contributions this paper: (1) develops a new mathematical model for the mass of an object called the wave-mass function using De Broglie’s mass and frequency relation and semi-structured complex numbers; (2) uses the new wave-mass function to determine what happens to an object traveling at the speed of light; (3) derives a relation between Schrödinger’s wave function and the new wave-mass function; (4) derives a relation between Einstein’s Field Equation and the new wave-mass function; (5) uses the wave-mass function to combine Einstein’s Field Equation with Schrödinger’s wave function to form a new quantum gravity equation. These results and their applications provide a firm foundation to advance the number set ℍ as a useful mathematical tool.

Process (or business process) management systems fulfill defining, executing, monitoring and managing process models deployed on process-aware enterprises. Accordingly, the functional formation of the systems is made up of three subsystems such as modeling subsystem, enacting subsystem and mining subsystem. In recent times, the mining subsystem has been becoming an essential subsystem. Many enterprises have successfully completed the introduction and application of the process automation technology through the modeling subsystem and the enacting subsystem. According as the time has come to the phase of redesigning and reengineering the deployed process models, from now on it is important for the mining subsystem to cooperate with the analyzing subsystem; the essential cooperation capability is to provide seamless integrations between the designing works with the modeling subsystem and the redesigning work with the mining subsystem. In other words, we need to seamlessly integrate the discovery functionality of the mining subsystem and the analyzing functionality of the modeling subsystem. This integrated approach might be suitable very well when those deployed process models discovered by the mining subsystem are complex and very large-scaled, in particular. In this paper, we propose an integrated approach for seamlessly as well as effectively providing the mining and the analyzing functionalities to the redesigning work on very large-scale and massively parallel process models that are discovered from their enactment event logs. The integrated approach especially aims at analyzing not only their structural complexity and correctness but also their animation-based behavioral properness, and becomes concretized to a sophisticated analyzer. The core function of the analyzer is to discover a very large-scale and massively parallel process model from a process log dataset and to validate the structural complexity and the syntactical and behavioral properness of the discovered process model. Finally, this paper writes up the detailed description of the system architecture with its functional integration of process mining and process analyzing. And more precisely, we excogitate a series of functional algorithms for extracting the structural constructs as well as for visualizing the behavioral properness on those discovered very large-scale and massively parallel process models. As experimental validation, we apply the proposed approach and analyzer to a couple of process enactment event log datasets available on the website of the 4TU.Centre for Research Data.

Organisms in the wild have cryptic life stages that are sensitive to changing environmental conditions and can be difficult to survey. In this study, I used mark-recapture methods to repeatedly survey Anaea aidea (Nymphalidae) caterpillars in nature, then modeled caterpillar demography as a hidden Markov process to assess if temporal variability in temperature and density influence the survival and growth of A. aidea over time. Individual encounter histories result from the joint likelihood of being alive and observed in a particular stage, and I included hidden states by separating demography and observations into parallel and independent processes. I constructed a demographic matrix containing the probabilities of all possible fates for each stage, including hidden states, e.g., eggs and pupae. I observed both dead and live caterpillars with high probability. Peak caterpillar abundance attracted multiple predators, and survival of fifth instars declined as per capita predation rate increased through spring. A time lag between predator and prey abundance was likely the cause of improved fifth instar survival estimated at high density. Growth rates showed an increase with temperature, but the most likely model did not include temperature. This work illustrates how state-space models can include unobservable stages and hidden state processes to evaluate how environmental factors influence vital rates of cryptic life stages in the wild.

Background: This study aimed to assess the impact of a nutrition-care bundle on growth and neurodevelopmental outcomes of micro-preterm infants born in a level III neonatal intensive care unit (NICU) by two years corrected age. Methods: A nutrition-care bundle emphasizing the prompt initiation of parenteral nutrition at birth, initiation of enteral feeds within 6 hours after birth, and early addition of human milk fortifiers was implemented in 2015 for infants born &lt;26 weeks gestation. This before-and-after study evaluated growth and neurodevelopmental outcomes in infants born between 2012-2013 (before-nutrition-bundle BNB) and 2016-2017 (after-nutrition-bundle ANB). Results: A total of 145 infants were included in the study. Infants in the ANB group (n=73) were smaller (birthweight and gestational age), and there were more male infants and multiples included compared to the BNB group (n=72). Enteral feeds and fortifiers started earlier in the ANB group. Growth velocity and weight-z-score changes were similar in both groups during NICU stay and post-discharge. Systemic steroid use, but not cohort, was linked to lower Bayley scores across all domains. Conclusions: Implementing a nutrition-care bundle was not consistently associated with improved weight-gain and neurodevelopmental outcomes in the micro-preterm infant population, likely due to ongoing high-quality nutritional care by the clinical team.

It was for long time believed that lidar systems based on the use of high-repetition micro-pulse lasers could be effectively used to only stimulate atmospheric elastic backscatter echoes, and thus only exploited in elastic backscatter lidar systems. Their application to stimulate rotational and roto-vibrational Raman echoes, and consequently their exploitation in atmospheric thermodynamic profiling, was considered not feasible based on the technical specifications possessed by these laser sources until a few years ago. However, recent technological advances in the design and development of micro-pulse lasers, presently achieving high UV average powers (1-5 W) and small divergences (0.3-0.5 mrad), in combination with the use of large aperture telescopes (0.3-0.4 m diameter primary mirrors), allow to presently develop micro-pulse laser-based Raman lidars capable to measure the vertical profiles of atmospheric thermodynamic parameters, namely water vapour and temperature, both in daytime and nighttime. This paper is aimed at demonstrating the feasibility of these measurements and at illustrating and discussing the high achievable performance level, with a specific focus on water vapour profile measurements. The technical solutions identified in the design of the lidar system and their technological implementation within the experimental setup of the lidar prototype are also carefully illustrated and discussed.

Mass transfer is often the rate determining step for solid-liquid chemical reactions. Decrease of the concentration boundary layer thickness is essential to intensify the chemical reaction. Because the concentration boundary layer exists in the velocity boundary layer, force imposition in the concentration boundary layer by superimposing an electrical current and a magnetic field was proposed. Through, flow can be directly excited in the concentration boundary layer. The previous result indicates that by superimposing a DC current and a gradient magnetic field, the development of the concentration boundary layer was suppressed, because of a macro-scale flow excitation in the whole vessel. And by superimposing the gradient magnetic field with a modulate current, the development of the concentration boundary layer was further suppressed. This is because of the macro-scale flow enhancement and the excitation of a micro-scale flow near the solid-liquid interface. However, the mechanism for the micro-scale flow excitation has not been clarified. To clarify this, a uniform magnetic field was superimposed with the DC current or the modulate current. By this means, only the micro-scale flow was excited near the anode surface. The results found that the non-unform electromagnetic force distribution is the main reason for the micro-scale flow excitation.

As the scarcity of potable water increases, recycling of treated wastewater is increasing. Small-scale, decentralized treatment can be implemented to serve local populations by keeping water within their boundaries and within reach for reuse, particularly in less dense, non-urban communities. Availability of cellular networks and high-speed internet connectivity, along with significant reduction in cost, allows ongoing monitoring of decentralized treatment systems at a central location. In this paper a decentralized treatment system using micro nanobubble aeration, moving media and membranes is able to produce reusable water with low energy consumption, thereby allowing the use of solar energy in places with unreliable electrical supply. The treatment system, which uses no external chemicals, is able to operate unattended and deliver clear, disinfected water with non-detect suspended solids, BOD5 less than 10 mg/L and nutrients below 5 mg/L.