ARTICLE | doi:10.20944/preprints202206.0055.v1
Subject: Chemistry And Materials Science, Organic Chemistry Keywords: Sulfonated silica catalyst (SiO2-SO3H); methyl salicylate; green chemistry; methylating agent; deacetylation (acyl nucleophilic substitution); solid acid catalyst
Online: 6 June 2022 (03:45:09 CEST)
SiO2-SO3H, with a surface area of 115 m2/g, pore volume of 0.38 cm3g-1 and 1.32 mmol H+/g, was used as a 20% w/w catalyst for the preparation of methyl salicylate (Wintergreen oil or MS) from acetylsalicylic acid (ASA). A 94% conversion was achieved in a microwave reactor during 40.0 minutes at 120 oC in MeOH. The resulting crude product was purified by flash chromatography. The catalyst could be re-used three times.