This research proposes a roof-mounted auxiliary power supply (APS) system for 600VDC low-floor light rail vehicle (LRV). The proposed APS system consists of five parallel-connected dc-ac inverter modules (modules 1-5). The inverter modules 1 and 2 are three-phase dc-ac inverters for compressor motors of the cooling system, and the inverter modules 3 and 4 are three-phase dc-ac inverters for air pump motors of the braking system. The inverter module 5 is single-phase dc-ac inverter for 220VAC power supply for onboard electric loads. Simulations and experiments were carried out under variable load torque and output frequency for modules 1 – 4; and under full and no resistive loads for the inverter module 5. The measured total input current and total input power of the proposed APS system under full load condition are 118.76A and 71.25kW. Essentially, the proposed APS system is operationally applicable to the 600VDC low-floor RLV. Besides, the novelty of this research lies in the use of five parallel-connected inverter modules, unlike in the conventional APS systems which require three-phase output transformer or isolated dc-dc converter. Specifically, the proposed APS system requires neither three-phase output transformer nor isolated dc-dc converter.

This article introduces a novel payload structure, which has been experimentally proven to have smaller impact force while the carried internal electronics remains intact. The study describes in details how materials and geometric structures were chosen based on information analysis. It is clarified how possible geometric structures and materials can be chosen to yield optimal efficiency. Finite element method simulations were carried out to investigate the mechanical properties of several geometric structures, which has led to the dodecahedron form. For the frame, Polylactic Acid were chosen as an optimal material. A low air pressure test for parts of the structure, and also the whole structure were carried out with successful results. Drop tests, with force measuring sensors and high speed videos, were carried out for measuring and comparing the maximal impact force of classical payloads and the novel one. Laboratory and real life tests demonstrated that the developed new structure is safer and it is applicable.

For underwater vehicles navigating in Arctic Sea ice-covered waters, fatigue damage is a crucial issue. Many scholars have conducted low-temperature fatigue analysis on low-temperature ma-terials and substrate platforms for ships, and the results show that low-temperature is beneficial for improving the mechanical properties of materials. However, they mainly focus on low-temperature performance experiments and simulation analysis of standard components of materials, and there are very few fatigue life experimental studies on underwater vehicle me-chanical structures. This paper conducts experimental investigations on a scaled model of an underwater vehicle rudder mechanism in a polar environment laboratory. Using a comparative analysis method involving simulations and experiments, the low-temperature fatigue test data of the scaled underwater vehicle rudder mechanism are analyzed, and the quantified analysis be-tween fatigue and different low-temperature loading cycles, as well as the influence of icing on the fatigue life, is explored. It is indicated that the arctic environment can decrease the fatigue life of the underwater vehicle rudder mechanism by deteriorating its material properties. The paper builds the foundation for the fatigue life of an underwater vehicle rudder mechanism in arctic low-temperature environments.

In this study, we explore the potential of using a straightforward neural network inspired by the retina model to efficiently restore low-light images. The retina model imitates the neurophysiological principles and dynamics of various optical neurons. Our proposed neural network model reduces the computational overhead compared to traditional signal-processing models while achieving results similar to complex deep learning models from a subjective perceptual perspective. By directly simulating retinal neuron functionalities with neural networks, we not only avoid manual parameter optimization but also lay the groundwork for constructing artificial versions of specific neurobiological organizations.

Based on the theory of turbulence, equations are derived for estimations of turbulent fluctuations of the longitudinal and transverse components of the wind velocity during ideal hovering of a quadcopter in a turbulent atmosphere. We present the results of experiments which were carried out on the territory of the Geophysical Observatory of Institute of Monitoring of Climatic and Ecological Systems, Siberian Branch, Russian Academy of Sciences, located in Tomsk Akademgorodok on the territory with complex orography, in a parkland zone with buildings of research institutes and motorways. Time series of turbulent fluctuations of the longitudinal and transverse components of wind velocity fluctuations were received with the use of an automated weather station, and time series of estimates of these components, from data of a DJI Phantom 4 Pro quadcopter during hovering. According to the automated weather station data, anisotropy was observed in one experiment during measurements in the atmosphere, but this phenomenon was not observed in the other experiment: the fluctuation spectra of all components of wind speed fluctuations coincide. The spectra of fluctuations of the longitudinal and transverse wind velocity components based on the automated weather station data and UAV telemetry are presented. The fluctuation spectra of these components for the automated weather station data and quadcopter generally coincide. The behavior of the spectra coincides with the spectrum which corresponds to Kolmogorov–Obukhov “–5/3” law within the inertial range. The turbulent spectra of the wind velocity fluctuations obtained with the use of the automatic weather station and with the unmanned aerial vehicle differ in the high-frequency spectral region.

A millimeter-wave microstrip leaky-wave antenna array based on the substrate-integrated waveguide (SIW) and the complementary split-ring resonator (CSRR) is proposed in this paper. The slow wave characteristics of the SIW are enhanced by etching two rows of symmetrical CSRR-type slots on the surface of the SIW layer. The magnetic coupling between the CSRR-SIW layer and equally spaced circular patches array on the upper layer realizes the radiation of electromagnetic energy. In the 23~30 GHz (relative bandwidth 26.4%) operating frequency band, the horizontal polarization radiation beam scanning from -62° to -2° is realized, with a peak gain of 9.6~11.7 dBi, and the cross-polarization ratio is more than 43.8 dB.

With the advent of deep learning, significant progress has been made in low-light image enhancement methods. However, deep learning requires enormous paired training data, which is challenging to capture in real-world scenarios.To address this limitation, this paper presents a novel unsupervised low-light image enhancement method, which first introduces the frequency domain features of images in low-light image enhancement tasks. Our work is inspired by imagining a digital image as a spatially varying metaphoric “field of light”, then subjecting the influence of physical processes such as diffraction and coherent detection back onto the original image space via a frequency-domain to spatial-domain transformation (inverse Fourier transform). However, the mathematical model created by this physical process still requires complex manual tuning of the parameters for different scene conditions to achieve the best adjustment. Therefore, we proposed a dual-branch convolution network to estimate pixel-wise and high-order spatial interactions for dynamic range adjustment of the frequency feature of the given low-light image. Guided by the frequency feature from the “field of light” and parameter estimation networks, our method enables dynamic enhancement of low-light images. Extensive experiments have shown that our method performs well compared to state-of-the-art unsupervised, and its performance approximates the level of the state-of-the-art supervised methods qualitatively and quantitatively. At the same time, the light network structure design allows the proposed method to have an extremely fast inference speed(nearly 150 FPS on an NVIDIA 3090 Ti GPU for an image of size 600×400×3 ). Furthermore, the potential benefits of our method to object detection in the dark are discussed.

In recent years, researches on combining wavelet decomposition and convolutional neural network (CNN) together to classify hyperspectral images (HSI) have emerged, and some effective classification models have been proposed and achieved good classification results. However, there are two problems for most of the proposed models. One is the heavy training parameters and the other is that there is no distinction between the classification effectiveness of low frequency and high frequency features after wavelet decomposition. In this paper, a new light-weighted HSI classification model (LLFWCNN) is proposed, which performs multi-layer wavelet decomposition for HSI after dimensionality reduction, and only arranges the low frequency features in a specific stack mode, then classifies them through a well-designed convolutional neural network. Compared with other classification models, the number of parameters is only 2.5% of that of other models. And only the low frequency features after wavelet decomposition are used, while the high frequency features are abandoned. The results showed that compared with the state-of-the-art classification models, LLFWCNN could obtain the same or even better classification results with fewer network parameters and proved that the low frequency features after wavelet decomposition provide LLFWCNN with more favorable information for HSI classification as well.

This study explores the significance of active suspension systems for vehicles with lower chassis compared to conventional ones, aiming at the development of future automobiles. Conventional linear MR (Magneto-Rheological) dampers were found inadequate in ensuring sufficient vibration control because the vehicle's chassis becomes lowered in the unmanned vehicles or purposed based vehicles. As an alternative, a rotary type of MR damper is proposed in this work. The proposed damper is designed based on pre-specified design parameters through mathematical modeling and magnetic field analyses. Subsequently, a prototype of the rotary MR damper identical to the design is fabricated, and effectiveness is shown through experimental investigations. In configuring the experiments, a proportional-integral (PI) controller is employed for current control to reduce the response time of the damper. The results presented in this work provides useful guidelines to develop a new type of MR damper applicable to various types of future vehicles’ suspension systems with low distance from the tire to the body floor.

In this letter, we show an alternative low-cost fabrication method to obtain poly(dimethyl siloxane) (PDMS) microfluidic devices. The proposed method allows the inscription of micron resolution channels on polystyrene (PS) surfaces, used as a mold for the wanted microchip’s production, by applying a high absorption coating film on the PS surface to ablate it with a focused low-power visible laser. The method allows obtaining micro resolution channels at powers between 2 and 10mW and can realize any two-dimensional polymeric devices. The effect of the main processing parameters on the channel’s geometry is presented.

Vehicle driveability is one of the important vehicle attributes in range-extender electric vehicles due to the electric motor torque characteristics at low-speed events. The process of validating and rectifying vehicle driveability attributes is typically utilised by a physical vehicle prototype that can be expensive and required several design iterations. In this paper, a model-based energy method to assess vehicle driveability is presented based on a high-fidelity 49 degree-of-freedom powertrain and vehicle systems. Multibody dynamics components were built according to their true centre of gravity relative to the vehicle datum for providing an accurate system interaction. The work covered a frequency at less than 20 Hz. The results that consisted of the component frequency domination are structured and examined to identify the low-frequency sensitivity based on different operating parameters such as a road surface coefficient. An energy path technique was also implemented on the dominant component by decoupling its compliances to study the effect on the vehicle driveability and low-frequency response. The outcomes of the research provided a good understanding of the interaction across the sub-systems levels. The powertrain rubber mounts were the dominant components that controlled the low-frequency contents (< 15.33 Hz) and can change the vehicle driveability quality.

In table tennis competitions the rule violation judgment with the greatest controversy is the height of the ball serve. This is because inaccuracy in the ball height judgment, which results in erroneous judgment, is unavoidable. Thus, we designed an automatic image judgment auxiliary system for table tennis ball height during service in this study. We used a high-speed camera to record the ball toss in the table tennis service. The designed algorithm architecture can automatically search for the ball and the position of the hand action under low light source conditions. The algorithm is mainly divided into hue-saturation-value color space processing and morphology processing using Hough transform to search for the circular ball. Experiment result shows that color segmentation can successfully and accurately determine the ball position under low light conditions. The morphology method can find the position of the hand and help determine the moment when the ball leaves the hand during the service ball toss. Finally, the actual size of the target is used to estimate the actual distance unit represented by the image pixel.

An ultra-low anti-reflection optical coating on both surfaces of a plastic cover slip was studied for use in confocal image measurement. The optical reflectance at a wavelength of 632.8 nm was less than 0.1% when the coated sample was placed in a liquid having a refractive index of 1.34 close to the aqueous solution of the biomaterial. The high- and low-index coating films, Substance-2 (PrTiO3) and silicon dioxide (SiO2), were measured by an ellipsometer to determine their optical refraction indices and extinction coefficients. Theoretically, when the two layer thicknesses are designed using the optical admittance diagram of the cover slip to approach the equivalent index of 1.34, a reflectance of 1.6×10-5% in the liquid could be obtained. Experimentally, the reflectance of the sample deposited on the two faces of the cover slip was 4.223±0.145% as measured in the air; and 0.050±0.002% as measured by a He-Ne laser in the liquid.

The copper end paste used in multilayer ceramic capacitors sintered in nitrogen atmosphere will lead to carbon residue of organic vehicle, which will lead to the reduction of electrode conduc-tivity and high scrap rate. With an attempt to leave no residue in the sintering, the compatibility of solvents and thickeners should be improved because it has an important influence on the hi-erarchical volatilization and carbon residue of organic vehicles. In this work, the volatility of different solvents was compared and several solvents were mixed in a definite proportion to prepare an organic vehicle with polyacrylate resins. The hierarchical volatility and solubility parameters of mixed solvents were adjusted effectively by changing proportions of different components, the thermogravimetric curves of resins and organic vehicles were measured by thermogravimetric analyzer, the effect of solubility parameter on the dissolvability of resins in the solvent and the residual of organic vehicles were studied. Results showed that the hierar-chical volatilization of solvents can be obtained by mixing different solvents; the intrinsic vis-cosity of the organic vehicle is higher and the thermal decomposition residue of polyacrylate resins is lower when the solubility parameters of mixed solvents and polyacrylate resins are closer. The low residual sintering of organic vehicles can be achieved by using the mixed solvent with hierarchical volatility and approximate solubility parameters as resins.

Background: The prevalence of atopic dermatitis in domestic animals is one of the problems of modern veterinary. Treating with standard techniques using chemotherapeutic agents not always leads to a positive result of therapy; moreover, many drugs produce adverse side effects. Methods: Low level laser therapy, in particular, intravenous laser blood illumination (ILBI) has a pronounced and long-lasting impact on the immune system of animals. The combined technique including ILBI-635 (635 nm, 2 mW, 5 min) and LUVBI^® (365 nm, 2 mW, 3 min) every other day provides a positive change in clinical status of cats with allergic dermatitis after the 3rd-4th treatment session. Results: The increased level of erythrocytes and hemoglobin was identified in the course of treatment, and it indirectly indicates increased blood transport activity, which improves trophic provision and microcirculation. A double reduction of leukocytes and a significant decrease of neutrophil cells indicate the immunomodulatory effect of LILI (low-intensity laser illumination). The increase in the percentage of lymphocytes and the decrease of eosinophils and monocytes against the background of basophil concentrations deviations within physiological concentration result in the reduction of inflammatory mediators expression that induce itching. The reduction of total IgE concentration 32 times against control on the 7th day of treatment correlates with the decrease in the quantitative content of peripheral blood eosinophils, indicating the decrease in severity of an allergic process. Conclusion: LLLT is recommended against the background of standard drug therapy to achieve quick clinical outcome together with a long-lasting prolonged effect.

The size of the population and the need for residential spaces are increasing. One possible solution is to add new floors to existing buildings. The positive aspects of such a solution with respect to its socio-economic impact and impact on the environment is that large amounts of carbon dioxide release will be avoided, waste and its treatment will be reduced, and agricultural land and green spaces will be preserved. However, adding floors to existing structures might be structurally challenging, especially in terms of the behavior under seismic actions. This paper presents a numerical study of a reinforced concrete frame in an old building to which new floors are subsequently added. The analysis shows that the frame does not behave as a whole with the old part of the structure, nor does it behave the same as if it were made with rigid joints compared to additional ones connected using hinge joints. The change from the corner (knee) joint to the external joint has its own effect on the distribution of internal forces in the structure as a whole and in the joint in particular.

Given the high number of vehicle-crash victims, it has been established as a priority to reduce this figure in the transportation sector. For this reason, many of the recent researches are focused on including control systems in existing vehicles, to improve their stability, comfort and handling. These systems need to know in every moment the behavior of the vehicle (state variables), among others, when the different maneuvers are performed, to actuate by means of the systems in the vehicle (brakes, steering, suspension) and, in this way, to achieve a good behavior. The main problem arises from the lack of ability to directly capture several required dynamic vehicle variables, such as roll angle, from low-cost sensors. Previous studies demonstrate that low-cost sensors can provide data in real-time with the required precision and reliability. Even more, other research works indicate that neural networks are efficient mechanisms to estimate roll angle. Nevertheless, it is necessary to assess that the fusion of data coming from low-cost devices and estimations provided by neural networks can fulfill the reliability and appropriateness requirements for using these technologies to improve overall safety in production vehicles. Because of the increasing of computing power, the reduction of consumption and electric devices size, along with the high variety of communication technologies and networking protocols using Internet have yield to Internet of Things (IoT) development. In order to address this issue, this study has two main goals: 1) Determine the appropriateness and performance of neural networks embedded in low-cost sensors kits to estimate roll angle required to evaluate rollover risk situations. 2) Compare the low-cost control unit devices (Intel Edison and Raspberry Pi 3 Model B), to provide the roll angle estimation with this artificial neural network-based approach. To fulfil these objectives an experimental environment has been set up composed of a van with two set of low-cost kits, one including a Raspberry Pi 3 Model B, low cost Inertial Measurement Unit (BNO055 - 37€) and GPS (Mtk3339 - 53€) and the other having an Intel Edison System on Chip linked to a SparkFun 9 Degrees of Freedom module. This experimental environment will be tested in different maneuvers for comparison purposes. Neural networks embedded in low-cost sensor kits provide roll angle estimations very approximated to real values. Even more, Intel Edison and Raspberry Pi 3 Model B have enough computing capabilities to successfully run roll angle estimation based on neural networks to determine rollover risks situation fulfilling real-time operation restrictions stated for this problem.

Prevention of obstetric trauma from damage to the pelvic floor is not always possible and sacral nerve stimulation (SNS) may be necessary later in life. Sacral nerve stimulation has been a promising innovation in the management of moderate to severe faecal incontinence and following sphincter repair failure. Although the indication spectrum for SNS is expanding, the success of neuromodulation for constipation is limited. Adverse events of SNS requiring re-intervention are not common but a long-term successful outcome may depend on interventions for maintenance of the device.

Stress urinary incontinence (SUI) influences the quality of life of women. The research applied ICIQ LUTS qol (The International Consultation Incontinence Questionnaire Lower Urinary Tract Symptoms quality of life) as a tool to measure the quality of life (QOL) of patients with stage 1 SUI in many areas. 140 perimenopausal women who participated in a urodynamic test at Department of Gynecology, Endocrinology and Gynecologic Oncology, Pomeranian Medical University, Police, Poland in the years 2013-2015 were enrolled in the study. Patients were divided into two groups: A and B. Two questionnaires were applied: the author’s original questionnaire and the standardized ICIQ LUTS qol. Gymnastic plans were recommended 4 times per week for the period of 3 months. The plan for group A included the exercises of pelvic floor muscles (PFM) with the simultaneous tension of the transverse abdominal muscle (TrA) and for group B included the exercises of PMF without TrA. The evaluation of the quality of life of patients with stage 1 SUI with the use of ICIQ LUTS qol among patients from groups A and B after therapy showed a significant improvement in most areas. More impact is observed in the physiotherapy of both PFM with TrA.

Floor mats are commonly used to improve the impact sound performance of existing homes, but the actual reduction does not consistently appear depending on the test-bed conditions used to determine it. Therefore, this study evaluated the effects of the environmental conditions of the test-bed on the impact sound reduction performance of different floor mats. The Korean Industrial Standard, KS F 2865, specifies the measurement method in the test room and sets the thickness range of the available target floor structure from bare slab 120 mm to 210 mm. The evaluation method is ∆?, which is the difference in standardized impact sound levels before and after the installation of the floor finishing material. In this study, a total of eight types of floor mats were tested in four different test-beds according to KS F 2865. The impact sources used were tapping, bang machines and a rubber ball to consider both light-weight and heavy-weight impact sounds. The results were derived as impact sound reduction performance for each frequency band and a single number quantity. The results showed that light impact sound had a similar minimum reduction characteristic of at least 38 dB, regardless of the floor structure on which the mat was installed. However, the heavy-weight impact sound showed different tendencies depending on the floor mat and the characteristics of the floor structure of the test-bed when a bang machine and a rubber ball were used. In particular, the reduction by the bang machine showed less than half the tendency of the reduction by the rubber ball, and the tendency of the heavy-weight impact sound to be reduced depending on the floor mat was maintained, but the reduction differed depending on the test bed. The reduction was larger in the box-type test room than in the real-life type test room, and among the box-type test rooms, the one with a thicker bare slab showed a relatively larger reduction. In addition, the reliability of the measurement results was discussed through the correlation analysis between the single number quantities depending on the thickness of the bare slab of the test-beds.

In municipal waterworks large amounts of waste in the form of sludge have to be discarded. This investigation focuses on the processing of ceramic floor tiles incorporated with a municipal waterworks sludge. Four floor tile formulations containing up to 10 wt. % of the municipal waterworks sludge in replacement of kaolin were prepared. The floor tile processing route consisted of dry powder granulation, uniaxial pressing, and firing between 1190 and 1250 °C using a fast-firing cycle (<60 min). The densification behavior and technological properties of the floor tile pieces as function of the sludge addition and firing temperature were determined. The development of the microstructure was followed by XRD and SEM/EDS. The results show that the replacement of kaolin with municipal waterworks sludge, in the range up to 10 wt. %, allows the production of ceramic floor tiles (group BIb and group BIIa, ISO 13006 Standard) at lower firing temperatures. These results suggest a new possibility for valorization of municipal waterworks sludge with many economical and environmental benefits.

The introduction of innovative digital tools for supporting manufacturing processes has far-reaching effects on an organizational and an individual level due to the development of Industry 4.0. The FACTS4WORKERS project funded by H2020, i.e. Worker-Centric Workplaces in Smart Factories, aims to develop user-centered assistance systems in order to demonstrate their impact and applicability at the shop floor. To do so it is important to understand how to develop such tools and how to assess if advantages can be derived from the created ICT system. This study introduces the technology of a workplace solution that is linked to a specific industrial challenge. Subsequently, a 2-stepped approach to evaluate the presented system is discussed. Heuristics, which are an output of project “Heuristics for Industry 4.0”, are used to test if the developed solution covers critical aspects of socio-technical system design. Insights into the design, development and holistic evaluation of digital tools at the shop floor should be shown.

The aim of this study was to evaluate implants survival rate, marginal bone loss, surgical and prosthetic complications of implants placed through sinus floor elevation and tilted implants en-gaged in basal bone in order to bypass maxillary sinus. 60 patients were enrolled for this study. According with residual bone height of posterior maxilla the sample was divided in three groups of 20 patients: Group A (lateral sinus floor elevation), Group B (transrectal sinus floor elevation) and Group C (tilted implants employed to bypass sinus floor). Follow-up visits were performed one week after surgery, at 3, 6 months and then once a year for next 4 years. The outcomes were implants survival rate, marginal bone loss and surgical and prosthetic complications. Although the Group A, B and C have demonstrated an implants survival rate of 83.3%, 86,7% and 98,3% respectively, the statistically analysis showed that there was no statistically significant difference between groups. Statistically significant differences between the groups were also not found con-cerning marginal bone loss, as recorded by intra-oral X-ray measurements during follow-up. About complications it wasn’t possible to perform a statistical analysis. To as to reduce potential surgical risks implants placement in basal bone should be preferred.

This paper presents a new framework to classify floor plan elements and represent them in a vector format. Unlike existing approaches using image-based learning frameworks as the first step to segment the image pixels, we first convert the input floor plan image into vector data and utilize graph neural network. Our framework consists of three steps. (1) image pre-processing and vectorization of the floor plan image. (2) region adjacency graph conversion. (3) graph neural network on converted floor plan graphs. Our approach is able to capture different types of indoor elements including basic elements such as walls, doors, and symbols as well as spatial elements such as rooms and corridors. In addition, the proposed method can also detect element shapes. Experimental results show that our framework can classify indoor elements with an F1 score of 95%, with scale and rotation invariance. Furthermore, we propose a new graph neural network model that takes the distance between nodes into account, which is a valuable feature of spatial network data.

As the energy efficiency demands for future buildings become increasingly stringent, preliminary assessments of energy consumption are mandatory. These are possible only through numerical simulations, whose reliability crucially depends on boundary conditions. We therefore investigate their role in numerical estimates for the usage of geothermal energy, performing annual simulations of transient heat transfer for a building employing a geothermal heat pump plant and energy piles. Starting from actual measurements, we solve the heat equations in 2D and 3D using COMSOL Multiphysics and IDA-ICE, and discover a negligible impact of the multiregional ground surface boundary conditions. Moreover, we verify that the thermal mass of the soil medium induces a small vertical temperature gradient on the piles surface. We also find a roughly constant temperature on each horizontal cross-section, with nearly identical values if the average temperature is integrated over the full plane or evaluated at one single point. Calculating the yearly heating need for an entire building we then show that the chosen upper boundary condition affects the energy balance dramatically. Using directly the pipes’ outlet temperature induces a 54% overestimation of the heat flux, while the exact ground surface temperature above the piles reduces the error to 0.03%.

Keywords: Wood residuals; Forest biomass; Wood composite; Wood floor; Life Cycle Assessment.

The need for quick and easy deflection calculations of various prefabricated slabs causes that simplified procedures and numerical tools are used more and more often. Modelling of full 3D finite element (FE) geometry of such plates is not only uneconomical but often requires the use of complex software and advanced numerical knowledge. Therefore, numerical homogenization is an excellent tool, which can be easily employed to simplify a model, especially when accurate modelling is not necessary. Homogenization allows for simplifying a computational model and replacing a complicated composite structure with a homogeneous plate. Here, a numerical homogenization method based on strain energy equivalence is derived. Using the method proposed, the structure of the prefabricated concrete slabs reinforced with steel spatial trusses is homogenized to a single plate element with an effective stiffness. There is a complete equivalence between the full 3D FE model built with solid elements combined with truss structural elements and the simplified homogenized plate FE model. The method allows for the correct homogenization of any complex composite structures made of both solid and structural elements, without the need to perform advanced numerical analyses. The only requirement is a correctly formulated stiffness matrix of a representative volume element (RVE) and appropriate formulation of the transformation between kinematic constrains on RVE boundary and generalized strains.

Water inrush from coal floor constitutes one of the main disasters in mine construction and mine production, which always brings high risks and losses to the coal mine safe production. As the mining depth of coal fields in North China gradually increased, especially in the complicated structural region, the threat posed by limestone karstic water of coal floor to the safe stoping of mines has become increasingly prominent. In this paper, the Taoyuan coalmine was taken as an example, for which, the directional borehole grouting technology was utilized to reinforce the coal seam floor prior to mining. Also, the factors affecting the grouting effect were analyzed. These were the geological structure, the crustal stress and the range of slurry diffusion. The layout principle of grouting drilling was put forward and the directional drilling structure was designed. The water level observations in the end hole indicated that the target stratum was accurate and reliable. The effect of grouting was validated through the audio frequency electric perspective method and the holedrilling in the track trough. The results demonstrated that the effect of grouting in third limestone and the rock stratum above the third limestone of coal seam floor was apparent. Simultaneously, no water inrush occurred following the actual mining of the working face, which further demonstrated that the grouting reinforcement effect was apparent. The research findings were of high significance for the prevention and control of floor water disaster and water conservation in deep complex structural areas.

Little is known about how the degree of mixing of forest-forming species affects forest floor hydrology. We evaluated the water storage capacity of the resulting litter layer by mixing litterfall of Scots pine and sessile oak and studying their decomposition time. We prepared 90 artificial samples containing pure pine litter, pure oak litter, and mixed pine-oak litter with varying shares of pine needles. These samples were subjected to 15 months of decomposition in soil. After every three months of decay, some samples were removed from the soil, and their water storage capacity, bulk density, and C:N ratio were evaluated. Our findings indicate that samples with the greatest water storage capacity had a low C:N ratio and a predominant share of oak leaves. Conversely, samples with a high C:N ratio and a predominant share of pine needles had the lowest water storage capacity. After 12 and 15 months of decomposition, the water storage capacity increased by more than 52% compared to the initial water capacity of the samples. The highest increase in water storage capacity (>40%) was observed in samples with a predominant share of oak leaves, while the lowest (approximately 28%) was recorded in samples with 80 and 100% of pine needles.

Abstract: Female pelvic floor dysfunction (FPFD) is a series of conditions caused by the displacement or dysfunction of the patient's pelvic organs due to defects, injuries, and deterioration of the pelvic floor supportive structures, with stress urinary incontinence and pelvic organ prolapse being the most common. The mechanism of pelvic floor dysfunction is complex and not yet fully understood, and is often related to one or more functional abnormalities of muscles, connective tissues, fascia, nerves and blood vessels. Specialized clinicians are often unable to cover the comprehensive medical professional information of various specialties such as gynecology and obstetrics, urology, anus and intestines, imaging, etc., and the systematic and comprehensive diagnosis and treatment of the disease will be limited. The application of artificial intelligence concepts in the medical field not only improves the diagnostic efficiency of physicians, but also provides reference and basis for the development of comprehensive treatment programs. This article follows and draws on the diagnosis and treatment process of pelvic floor dysfunction recommended in various guidelines, incorporates physical therapy techniques into the conventional non-surgical treatment of pelvic floor dysfunction, provides guidance for the diagnosis and treatment of pelvic floor dysfunction, and briefly introduces the clinical application and value of pelvic floor intelligent diagnosis and treatment in pelvic floor dysfunction.

In this paper, we analyze the measurements of the normalized radar cross-section(NRCS) in Wave Mode for Chinese C-band Gaofen-3(GF-3) synthetic aperture radar (SAR). Based on 2779 images from GF-3 quad-polarization SAR in Wave Mode and collocated wind vectors from ERA-Interim, we verify the feasibility of using ocean surface wind fields and VV-polarized NRCS to perform normalized calibration. The method uses well-validated empirical C-band geophysical model function (CMOD4) to estimate the calibration constant for each beam. The Amazon rainforest experiment results show that the accuracy of obtained calibration constant meets the requirements. In addition, the relationship between cross-pol NRCS and wind vectors is discussed. The cross-pol NRCS increases linearly with wind speed and it has an approximate cosine modulation with the wind direction when the wind speed is greater than 8m/s. The cross-polarized system noise floor is low enough to ignore it in wind retrieval. Furthermore, we also investigate the properties of the polarization ratio, denoted PR, and show that it is dependent on incidence angle and azimuth angle. Two empirical models of the PR are fitted, one as a function of incidence angle only, the other with additional dependence on azimuth angle. Assessments show that the σ_VV^0 retrieved from new PR models as well as σ_HH^0 is in good agreement with σ_VV^0 extracted from SAR images directly. And it is also shown that considering the azimuth angle can improve polarization conversion accuracy.

In order to study the way how to improve the spatial action of precast monolithic composite floor slabs, and would replace the cast-in-place surface layer for reduce the weight of structure, using pseudo-dynamic tests on 1/4 scale models of two-span and three-story frame structure. The lateral load tests compared the stresses and displacements with cast-in-place floor frame-shear wall structure (SJ1) and precast monolithic floor frame-shear wall structure with X horizontal braces at the bottom of the floor (SJ2). The results show the X horizontal braces can improve the spatial action. Structural integrity (SJ2) as well as the effective transmission of the horizontal force can be ensured by additional X bracing at the bottom of the rigidity of the floor without cast-in-place concrete topping. The results show that X horizontal braces more effectively transfer horizontal, which provides a beneficial reference for similar research.

The aim of this study was to examine the relationship of the distance between the apex tip of the upper central tooth (U1A) and the anterior nasal spine (ANS) and the nasal floor (NF) with the vertical cephalometric values using cone-beam computerized tomography (CBCT). A total of 122 patients who applied to Department of Orthodontics between January 2011-June 2019 were included. On the CBCT’s, distances between the U1A and the NF and ANS were measured. Statistical significance was considered as p&lt;0.05. Of 122 individuals 73.8% (n=90) were female and 26.2% (n=32) were male with an mean age of 22,8±3,3 years. A statistically significant moderate positive correlation was found between the NF-U1A mean values and the measurements of N-Me, ANS-Me and ANS-Gn, S-Go, and N-ANS measurements (p &lt;0.01). A statistically significant positive correlation was found between the ANS-U1A mean values and Ar-Go-Me, total posterior angles, N-Me, SN/GoGn and Y-axis angle, ANS-Me and ANS-Gn (p &lt;0.01). In this study, we found that the distance of U1A from ANS and NF points was related to orthodontic vertical direction parameters. It was demonstrated that the ANS-U1A and NF-U1A points can serve as reference points for identifying the orthodontic vertical growth pattern on CBCT scans.

This paper reports modelling outcomes for improvements to building energy performance in Indonesia. Long-term climate effects due to building energy demands including carbon emissions are also considered. The global change assessment model (GCAM) was used to generate the related end-user building energy data, including socioeconomics for urban areas of Indonesia. As a comprehensive study, the total life cycle of carbon in the building sector and the concept of zero-carbon buildings, including energy efficiency, zero-emissions electricity and fuel switching options were considered. Building shell conductance (u-value) of building envelope, floor area ratio (FAR), air conditioner (AC) efficiency, electrical appliances (APLs) efficiency, rooftop photovoltaic (PV) performance and ground source heat pump (GSHP) systems were considered as parameters to mitigate carbon emissions under the operational energy category in GCAM. Carbon mitigation associated with the cement production process was considered in the raw material category. Urban population and labour productivity in Indonesia were used as base inputs with projected growth rates to 2050 determined from available literature. Low growth rate ‘LowRate’ and high growth rate ‘HighRate’ were considered as variable inputs for u-value, FAR, AC efficiency, APLs efficiency, and PV capacity factor to model emissions mitigation. The energy consumption of the GSHP was compared to the conventional reverse cycle ACs to identify the potential of the GSHP as a fuel-switching option. Only base input data were used for cement production process parameters without applying any variable inputs. GCAM base scenarios based on input data only (without modifying variable data) for the residential building sector in Indonesia were considered the benchmark for this study. Total potential carbon emissions mitigation was found to be 432 Mt CO2-e for the residential building sector in Indonesia over 2020-2050. It was found that an average of 24% carbon emissions mitigation could be achieved by 2020-30 and 76% in 2031-2050.

Research has been growing on object detection using semi-supervised methods in past few years. We examine the intersection of these two areas for floor-plan objects to promote the research objective of detecting more accurate objects with less labelled data. The floor-plan objects include different furniture items with multiple types of the same class, and this high inter-class similarity impacts the performance of prior methods. In this paper, we present Mask R-CNN based semi-supervised approach that provides pixel-to-pixel alignment to generate individual annotation masks for each class to mine the inter-class similarity. The semi-supervised approach has a student-teacher network that pulls information from the teacher network and feeds it to the student network. The teacher network uses unlabeled data to form pseudo-boxes, and the student network uses both unlabeled data with the pseudo boxes and labelled data as ground truth for training. It learns representations of furniture items by combining labelled and unlabeled data. On the Mask R-CNN detector with ResNet-101 backbone network, the proposed approach achieves mAP of 98.8%, 99.7%, and 99.8% with only 1%, 5% and 10% labelled data, respectively. Our experiment affirms the efficiency of the proposed approach as it outperforms the fully supervised counterpart using only 10% of the labels.

The German government's ambitious goal of achieving CO2-neutrality by 2045 has prompted a focus on improving building insulation as a vital step toward energy efficiency. However, in this process, existing radiators and boilers are often left unchanged, leading to inefficiencies due to oversized heating systems. This paper presents various approaches to reduce the required radiator inlet temperature, drawing on data from 100 multifamily buildings. The approaches include heat reserve reduction, heat power shifting, uniform radiator usage, and heat requirement analysis. These approaches collectively aim to lower flow temperatures and decrease peak heat loads, reducing energy consumption, and minimizing waste in compliance with the user comfort temperature. The findings reveal that the application of these methods can lead to substantial temperature reductions, with an average decrease of 20.82 K and 7.28 K for the highest necessary flow temperature in the provided example. Furthermore, peak load reductions of 21.07% and 13.65% were achieved, demonstrating the potential to enhance energy efficiency. While each approach can be applied individually, their synergistic implementation can highly increase the efficiency of water to x heat pumps, due to the lower required flow temperatures.

Climate change is increasing air temperatures and altering the precipitation and hydrological re-gime on a global scale. Challenges arise when assessing the impacts of climate change on the local scale for water resources management proposes, especially for low mountain headwater catch-ments that not only serve as important water towers for local communities, but also have distinct hydrological characteristics. Until now, no low flow or hydrological drought studies have been carried out on the Lauter River. This study is unique in that it compares the Lauter River, a transboundary Rhine tributary with a nearby station on the River Rhine just below its confluence at the French-German border. The Lauter catchment is a mostly natural, forested catchment, however, its water course has been influenced by past and present cultural activities. Climate change disturbances cascade through the hydrologic regime right down to the local scale. As we are expecting more low flow events, the decrease in water availability could cause conflicts be-tween different water user groups in the Lauter catchment. However, the choice of different methods for identifying low flow periods may cause confusion for local water resources manag-ers. Using flow rate time series of the Lauter River between 1956 and 2022 we compare for the first time three low flow identification methods: the variable threshold method (VT), the fixed threshold method (FT), and the Standardized Streamflow Index (SSI). Similar analyses are applied and compared to the adjacent Maxau station on the Rhine River for the same time period. This study aims at 1) interpreting the differences amongst the various low flow identification methods and 2) revealing the differences in low flow characteristics of the Lauter catchment compared to the Rhine River. It appears that the FT reacts faster to direct climate or anthropogenic impacts whereas VT is more sensitive to indirect factors such as decreasing subsurface flow which is typical for small headwater catchments, such as the Lauter where flow dynamics react faster to flow disturbances. Abnormally low flow during the early Spring in tributaries such as the Lauter can help predict low flow conditions of the Rhine River during the following half year and espe-cially for the summer. The results could facilitate Early Warning of hydrological droughts and drought management for water users in the Lauter catchment and further downstream along some of the Rhine.

As the PCIe 6.0 specification places higher requirements on signal integrity and transmission la-tency, it becomes especially important to improve signal transmission performance at the physical layer of the transceiver interface. Retimer circuit as a key component of high-speed serial interface, its delay and jitter size directly affect the overall performance of PCIe. For the conventional Retimer circuit with large latency and low jitter performance, this paper proposes a low latency and low jitter Retimer circuit based on CDR+PLL architecture for PCIe 6.0, using a jitter canceling filter circuit to eliminate the frequency difference between the retiming clock and data, reduce the retiming clock jitter, and improve the quality of Retimer output data; The data is sampled using the retiming clock and then output, avoiding the problem of large penetration latency of con-ventional Retimer circuits. The circuit is designed using CMOS 28nm process. Simulation results show that when 112Gbps PAM4 data is input to the Retimer circuit, the Retimer penetration la-tency is 27.3 ps, which is 83.5% lower than the conventional Retimer structure; the output data jitter is 741 fs, a 31.4% reduction compared to the conventional Retimer structure.

Failure characteristics induced by unloading disturbance and the corresponding mechanical mechanism of the coal seam floor are important theoretical bases for water-bursting prevention from the floor of the coal seam and rock burst alarm in deep mining. However, the existing two-dimensional ground-pressure-control theory based on shallow mining cannot sufficiently guide deep-mining practices. In this study, the redistribution of mining-induced stress field in rocks surrounding the longwall face and mechanical behaviors of strata in deep mining are investigated through a combination of numerical simulation, physical simulation, and field measurement. Results demonstrate that mining-induced stress fields in the floor of the longwall face differ in space and time. Vertical stress unloading from top to bottom of the floor and horizontal stress unloading are relatively low. A concentration zone of high horizontal stress exists at stope boundaries. The critical yield load of rock stratum in the floor is determined through thin plate yield theory. Under the combined effect of concentrated high horizontal and vertical resilience stresses, strata in the floor fracture from seam to seam if the load increases to the minimum critical buckling value. Fractured strata slide along the fracture surface, which leads to floor heave. The stope floor shows evident time-delay progressive failure characteristics. The stress shell in the stope floor in deep mining is found to be a sensitive mechanical parameter that produces three-dimensional ground-pressure behavior in the floor. This ground-pressure behavior in the stope floor is controlled by the existence of the corresponding stress shell and effects induced by its space–time evolution. This study provides theoretical basis for the dynamic control of a hazard-inducing environment in engineering and minimizing or altering disaster-occurrence conditions during the construction engineering of the coal seam floor.

Near-infrared spectroscopy (NIRS) was implemented to monitor the moisture content of broadleaf litters. Partial least-squares regression (PLSR) models, incorporating optimal wavelength selection techniques, have been proposed to better predict the litter moisture of forest floor. Three broadleaf litters were used to sample the reflection spectra corresponding the different degrees of litter moisture. Maximum normalization preprocessing technique was successfully applied to remove unwanted noise from the reflectance spectra of litters. Four variable selection methods were also employed to extract the optimal subset of measured spectra for establishing the best prediction model. The results showed that the PLSR model with the peak of beta coefficients method was the best predictor among all candidate models. The proposed NIRS procedure is thought to be a suitable technique for on-the-spot evaluation of litter moisture.

The occurrence rate of occupational accidents caused by slipping and falling is 50% worldwide. Determining the slip safety risk is necessary to minimize the accidents caused by slipping in pedestrian walking areas. By on-site testing, this study aims to determine the slip risks of floor coverings used in walking areas with many pedestrians in public service buildings (PSB). For this purpose, on-site measurements were performed in two environments and six locations in PSB using portable GMG 200 and pendulum testers operating according to DIN 51131 and TS EN 14231 standards. These tests were performed on four-floor coverings with polished surface treatment in PSB. Since the floor coverings measured have a polished surface, it can be seen that the dynamic friction coefficients (DCOF) values are very low, and the slip risks are high. By statistically analyzing the slip test data using the K-means method, a new safety classification was made according to the usage areas of floor coverings. To minimize the risk of slip safety, especially for students, patients, and employees in PSB, it is recommended to use floor coverings with high DCOF values and low slip risk.

Bamboo engineering materials are green, high-strength, tough, durable, and structurally safe, and have promising application prospects in various modern green and low-carbon buildings. To invest the vibration behavior of new bamboo bundle veneer -laminated lumber (BLVL) for use in floor slabs, this study designed two kinds of full-scale vibration tests under a pedestrian load: an extraction hammer impact test, and a static concentrated load test, it is expected to provide theoretical and data support for the application of bamboo bundle veneer laminated composite materials in the construction field. The results showed that the self-oscillation frequency and mid-span deflection of the BLVL composite met the requirements of multiple relevant regulations when used as the structural material of floor slabs. The BLVL floor slab had a higher flexural stiffness and better vibration-damping performance than the OSB floor slab. The first-order self-oscillation frequency of the BLVL composite floor slab was 13.769 Hz, the damping ratio of the first three orders of modalities was 1.262–2.728%, and the maximum static deflection in the span of the joist was 0.932 mm under a 1 kN concentrated load. The 1 kN static deflection of the BLVL was reduced by 22.33%, and the root mean square (RMS) acceleration of the walking load response was significantly lower than that of the OSB floor slab. The preparation of BLVL composite materials by homogeneous lamination of bamboo bundle veneer and wood veneer may help improve the vibration behavior of bamboo-wood structures such as floor slabs and walls.

African scientific research faces formidable challenges, particularly with limited access to state-of-the-art measurement instruments. The high cost associated with these devices presents a significant barrier for regional research laboratories, impeding their ability to conduct sophisticated experiments and gather precise data. This predicament not only hampers the individual laboratories but also has broader implications for the African scientific community and the advancement of knowledge in developing nations—the financial cost barrier considerably impacts the research quality of these laboratories. Reflection on technical and economical solutions needs to be quickly found to help these countries advance their research. In civil Engineering, the thermal conductivity property is the most important measurement for characterising heat transfer in construction materials. Existing devices (i.e., conductometers) in a laboratory are expensive (approximately 30,000 euros) and unavailable for some African laboratories. The study proposes a new and affordable device to evaluate thermal conductivity in construction materials. The method involves establishing a thermal flux between a heat source ( from the Joule effect provided by steel wool where a current is circulating) and a cold source (generated by ice cube) under steady-state conditions. The development of the cylindrical prototype is based on the comparative flux-meter method outlined in the measuring protocol of the ASTM E1225 standard document. Experiments were conducted on four distinct materials (polystyrene, wood, agglomerated wood, and rigid foam). The results indicate a correct correlation between the experimental values obtained from the newly developed prototype and the reference values found in the literature. For example, concerning the experimental polystyrene study, the detailed case analysis reveals a good correlation, with a deviation of only 4%. The percent error found falls within the acceptable range indicated by the standards recommendations of the ASTM E1225 standard, i.e., within 5% acceptable error.

A novel low-power MOS-only voltage reference is presented. The Enz-Krummenacher-Vittoz (EKV) model is adopted to provide a new perspective on the operating principle. The normalized charge density, introduced as a new variable, serves as an indicator when trimming the output temperature coefficient. The proposed voltage reference consists of a specific current generator and a 5-bit trimmable load. Thanks to the well-match between the current source stage and the output stage, the non-linear temperature dependence of carrier mobility is automatically canceled out. The circuit is designed in 55 nm COMS technology. The operating temperature ranges from -40 ∘C to 120 ∘C. The average temperature coefficient of the output voltage can be reduced to 21.7 ppm/∘C by trimming. The power consumption is only 23.2 nW with a supply voltage of 0.8 V. The line sensitivity and the power supply rejection ratio at 100 Hz are 0.011 %/V and -89 dB respectively.

The present study investigates the role of a simple inerter in supplemental devices for possible implementation in the matured seismic base isolation technique. Firstly, the response of the base-isolated structure with an optimally tuned mass damper-inerter (TMDI) is investigated to see the tuning effects. The time required to tune the TMDI was found to be significantly longer than the duration of a strong-motion earthquake. There was still a reduction in the response of the isolated structure, which is primarily due to the added damping and stiffness (ADAS) of TMDI and not because of the tuning effects. Hence, it is proposed that the corresponding ADAS of the TMDI be directly added to the isolation device. Secondly, the response of the base-isolated structures with the fluid inerter damper (FID) is studied. It was observed that the inerter of the FID does not influence the displacement variance of an isolated structure under broadband earthquake excitation. It implies that the response of the isolated structure with FID is primarily controlled by its counterpart fluid damper (FD). The performance of optimal TMDI, ADAS, FID, and FD to mitigate the seismic response of the flexible multi-story base-isolated structure under real earthquake excitations is also investigated. In terms of suppressing the displacement and acceleration responses of the isolated structure, it has been found that TMDI and ADAS perform similarly. Comparing the response of the isolated structure with FID and FD demonstrated that the inerter in the FID has detrimental effects on the isolated structures, in which the top floor's acceleration and base shear are substantially increased.

The present work presents and discusses an analysis of the floor types of Villa of Diomedes (Pompeii archaeological park in the Campania region, Italy) both from architectural, archaeological, and structural point of view. In particular, the geometrical structural parameters of different floor types and the rules used by ancient builders to design them are investigated by means of interdisciplinary research. Link between structural-based assumptions, archival sources, geometric survey, in situ visual inspections and the archaeological information make it possible to define the geometrical structural parameters of eleven-barrel vaults, three wooden floors and three sloped wooden roofs (buried and collapsed during the Vesuvius eruption). A specific study of the barrel vaults is presented to investigate the relationships between the main vaults’ structural parameter. Furthermore, a comparison between the vaults’ dimensions obtained from surveys and those produced by the literature formulations from the 15th to the 20th centuries concerning masonry-vault designs is presented and discussed. These analyses carried out in the framework of Villa of Diomedes interdisciplinary project was very useful to interpret the fabrication of the Villa and to make a reconstruction of 3D model as it probably resulted to be the fateful year of 79 A.D.

Serious damage caused by floor heave in the coal given chamber of a vertical coal bunker is one of the challenges faced in underground coal mines. Engineering practice shows that it is more difficult to maintain the coal given chamber (CGC) than a roadway. More importantly, repairing the CGC during mining practice will pose major safety risks and reduce production. Based on the case of the serious collapse that occurred in the bearing structure of the CGC at the lower part of the 214# coal bunker in Xiashijie mine, China, this work analysed (i) the main factors influencing floor heave and (ii) the failure mechanism of the load-bearing structure in the CGC using FLAC^2D numerical models and expansion experiment. The analysis results indicate that: the floor heave, caused mainly by mine water, is the basic reason leading to the instability and repeated failure of the CGC in the 214# coal bunker. Then a new coal bunker, without building the CGC, is proposed and put into practice to replace the 214# coal bunker. The FLAC^3D software program is adopted to establish the numerical model of the wall-mounted coal bunker (WMCB), and the stability of the rock surrounding the WMCB is simulated and analysed. The results show that: (1) the rock surrounding the sandstone segment is basically stable. (2) The surrounding rock in the coal seam segment, which moves into the inside of the bunker, is the main zone of deformation for the entire rock mass surrounding the bunker. Then the surrounding rock is controlled effectively by means of high-strength bolt–cable combined supporting technology. According to the geological conditions of the WMCB, the self-bearing system, which includes (i) H-steel beams, (ii) H-steel brackets, and (iii) self-locking anchor cables, is established and serves as a substitute for the CGC to transfer the whole weight of the bunker to stable surrounding rock. The stability of the new coal bunker has been verified by field testing, and the coal mine has gained economic benefit to a value of 158.026174 million RMB over three years. The new WMCB thus made production more effective and can provide helpful references for construction of vertical bunkers under similar geological conditions.

Low volatility ETFs have become popular in recent year because investors are starting to understand the advantages involved in investing in those ETFs compared to traditional index investment. In this research I have examined the performance of six popular low volatility ETFs, four of them invest in U.S stocks and the other two invest in other developed and emerging markets. Results have pointed out that not only five of the low volatility ETFs have exposed their investors to lower risk, four of them have also produced higher returns. The advantage of investing in low volatility ETFs is prominent in the U.S stock market. All three sizes of stocks categories (Large, Mid and Small Capitalization) low volatility ETFs have outperformed their indexes bench marks in terms of risk and returns. For the non U.S stock investing, while no advantage have been found for investing in low volatility ETFs for developed countries, significant lower risk was found for emerging markets.

Logistics industry has been found to be among the key sources of carbon emission. In Vietnam logistics industry, there is a considerable difference between the number of foreign and Vietnamese firms as well as the proportion of markets that they are taking. This study is to research the low-carbon emission measures conducted by domestic and foreign invested logistics service providers (LSPs) and compare the results of the two groups. Both qualitative and quantitative approaches are applied. Literatures in relevant fields are reviewed and expert opinions are taken for structuring a questionnaire which was later distributed to 279 LSPs, with 166 returned and 159 being valid for data calculation. The results imply that there are differences in extension of applications of low-carbon practices between foreign and domestic firms. Except for transport mode switch and energy-saving lighting, the other practices witness that adoption levels of foreign LSPs are higher than their counterparts, which is possibly thanks to their global operation, more comfortable capital resources and awareness level of green initiative necessity. In conclusion, a comparison between the application conducted by foreign-invested firms and domestic ones, which has not been investigated before, was made.

Background. ADHD is a neurodevelopmental disorder that is accompanied by executive deficits. Objectives. To obtain evidence of the usefulness of the BRIEF-P and to analyse the possible ceiling and floor effect of its scores in the assessment of executive function in preschoolers with signs compatible with a possible diagnosis of ADHD. Methods. Seven articles were selected from 2538 potentially eligible articles from different databases. We included studies assessing samples of individuals with symptoms compatible with ADHD, with age range 2-6 years, published in English or Spanish, during the period 2012-2022. References published in: Science Direct, NCBI (PubMed), ProQuest Education Journals in the last decade. Risk of bias was assessed using the QUADAS-2 questionnaire. The main variables were: age and executive functioning. Conclusions. Executive deficits in early-life individuals with ADHD-compatible symptoms are more extensive than deficits in working memory. BRIEF-P is an instrument that facilitates obtaining a sensitive and discriminative executive profile. It should be used in combination with other neuropsychological performance tests, finding a floor effect in tests associated with warm executive functions and a ceiling effect in cold executive functions. This requires using a variety of tests to assess executive performance in preschoolers with symptoms compatible with ADHD and designing intervention proposals in line with them...

Object detection is one of the most critical tasks in the field of Computer vision. This task comprises identifying and localizing an object in the image. Architectural floor plans represent the layout of buildings and apartments. The floor plans consist of walls, windows, stairs, and other furniture objects. While recognizing floor plan objects is straightforward for humans, automatically processing floor plans and recognizing objects is a challenging problem. In this work, we investigate the performance of the recently introduced Cascade Mask R-CNN network to solve object detection in floor plan images. Furthermore, we experimentally establish that deformable convolution works better than conventional convolutions in the proposed framework. Identifying objects in floor plan images is also challenging due to the variety of floor plans and different objects. We faced a problem in training our network because of the lack of publicly available datasets. Currently, available public datasets do not have enough images to train deep neural networks efficiently. We introduce SFPI, a novel synthetic floor plan dataset consisting of 10000 images to address this issue. Our proposed method conveniently surpasses the previous state-of-the-art results on the SESYD dataset and sets impressive baseline results on the proposed SFPI dataset. The dataset can be downloaded from SFPI Dataset Link. We believe that the novel dataset enables the researcher to enhance the research in this domain further.

Digital-based differential amplifiers (DDA) are particularly suitable to low voltage digital integrated circuit technologies. This paper presents an exhaustive analysis of the digital-based analog amplifiers to take advantage of today's high-performance digital technologies and of computer-aided design (CAD) commonly employed to design integrated circuits. The operating principle and the main mathematical relations of the digital-based differential amplifiers are discussed along with an exhaustive explanation of its operating regions and of the corresponding power consumption. Finally, a detailed description of the design procedure of in UMC 180nm standard CMOS technology is shown.

HER2-low and ultra-low breast cancer (BC) have been recently proposed as new subcategories of HER2 BC, re-considering the immunohistochemical negative score of 0, 1+ or score of 2+/in situ hybridization (ISH) negative phenotype. In the present review we have outlined the needed criteria to exactly distinguish HER2 low and ultra-low BC. Recent clinical trials have demonstrated significant clinical benefits of novel HER2 directing antibody-drug conjugates (ADCs) in treating these group sof tumors. In particular, Trastuzumab-deruxtecan (T-Dxd), a HER2-directing ADC has been recently approved by the U.S. Food and Drug Administration as the first targeted therapy to treat HER2-low BC. Furthermore, ongoing trials, such as the DESTINY-Breast06, are currently evaluating ADCs in patients with HER2-ultra low BC. Finally we hope that new guidelines may help to codify HER2 low and ultra-low BC, increasing our knowledge of tumor biology and improving a targetable new therapeutical treatment.

Multidisciplinary Design Optimization (MDO) is the most active field in the design of current complex system engineering, which is possessed with such two difficulties as subsystem information exchange and analytical and computational complexity of systems. Therefore, an improved collaborative optimization algorithm based on ANN (artificial neural network) response surface was proposed dependent on the consistency constraint algorithm and concurrent subspace algorithm. As an optimization method with secondary structure, it satisfied only local constraints in discipline layer, but provided a coordinated mechanism for interdisciplinary conflict in system layer. Finally, it was applied in the multidisciplinary design optimization of autonomous underwater vehicle (AUV). As shown from the result, the MDO convergence stability and reliability of low resistance, low noise and high maneuvering performance of the AUV shape can be ensured by the improved collaborative optimization algorithm, thus verifying the effectiveness of the algorithm.

To estimate the progressive collapse resistance capacity of a multi-column frame tube structure with the assembled truss beam composite floor (ATBCF), the pushdown analysis, and the nonlinear dynamic analysis as well, are conducted for such a structure by using the alternate load path (ALP) method. The bearing capacities of the remaining structures at three different work conditions, which are the side middle column failure, the edge middle column failure, and the corner column failure, are individually studied, and the collapse mechanism for the remaining structures is analyzed from the aspects of the internal force redistribution and the failure mode of the second defense line. Simultaneously, the influence of the column failure time on the dynamic response of the remaining structure and the dynamic amplification coefficient are discussed. The results show that the residual bearing capacity of the remaining structure with the bottom corner column failure is higher than that of the one with the side or edge middle column failure, while the latter has a stronger plastic deformation capacity. When the ALP method is adopted to operate the progressive collapse analysis, it is reasonable to take the column failure time as 0.1 times of the first-order vertical vibration period of the remaining structure, and it is suitable to set the dynamic amplification coefficient as of 2.0, which is the ratio of the maximum dynamic displacement to the static displacement of the remaining structure under the transient loading condition.

Poly(2,6-dimethyl phenyl oxide) (PPO) is known for its low dissipation factor. To achieve insulating materials with low dissipation factor for high-frequency communication application, a monomer-type benzoxazine (P-APPO) and a main-chain-type benzoxazine (BPA-APPO) were prepared from an amine end-capped oligo (2,6-dimethyl phenylene oxide) (APPO). The APPO was prepared from a nucleophilic substitution of a phenol-end capped oligo (2,6-dimethyl phenylene oxide) (a commercial product, SA 90) with fluoronitrobenzene, and followed by catalytic hydrogenation. After self-curing or curing with a dicyclopentadiene-phenol epoxy (HP 7200), thermosets with high-T_g and low-dissipation factor can be achieved. Furthermore, the resulting epoxy thermosets show better thermal and dielectric properties than those of epoxy thermoset cured from its precursor SA90, demonstrating it is a successful modification in simultaneously enhancing the thermal and dielectric properties.

To achieve rapid post-earthquake repair of self-centering ribbed floor flat beam frame structures, a ductile hybrid joint consisting of dog bone weakened energy dissipating steel bars connected to the upper and lower column sections through high-strength threads based on the damage control design concept is proposed. By moving the ductile energy dissipating zone out to the locally weakened section of the energy dissipating steel bars and the locally unbonded prestressed steel bars in the core area, the residual deformation was limited and the seismic performance was improved. Based on the working principle of hybrid joints, low cycle loading tests were conducted on two joint specimens to analyze the influence of lateral prestress on the seismic performance of the hybrid joints. Numerical modeling methods were used to compare the position of the energy-consuming steel bars in the composite layer and the friction performance of joints. The research results indicated that the hybrid joint had stable load-bearing, deformation, and energy dissipation capabilities, with damage primarily concentrated on the energy-consuming steel bars. Even at an inter-story displacement angle of 5.5%, the upper and lower column segments remained elastic. After unloading, the connection seam at the joint was closed, and the self-centering performance was good. When the inter-story displacement angle reached 5.5%, the lateral prestress increased from 150 kN to 250 kN, the ultimate bearing capacity of the joint increased by 16.3%, and the cumulative energy consumption increased by 30.0%. The influence of the friction coefficient of the joint surface on the structural performance was set at a threshold of 0.7. When it was less than the threshold, the ultimate bearing capacity and initial stiffness of the joint increased with an increase in the friction coefficient. After reaching the threshold, the increase in the ultimate bearing capacity of the joint slowed down, and the rate of stiffness degradation gradually accelerated. This joint had excellent seismic performance and can also achieve post-earthquake repair of structures.

The influence of the Fe2O3 addition amount on the dephosphorization of hot metal at 1623 K with the slag of the low basicity (CaO/SiO2) of about 1.5 was investigated by using high-temperature laboratorial experiments. With increasing the Fe2O3 addition amount, the contents of [C], [Si], [Mn] and [P] in hot metal at the end of dephosphorization decrease, and the corresponding removal ratios increase. The P2O5 content in slag increases, and the CaO and SiO2 contents in slag decrease. The phosphorus mainly exists in the form of the nCa2SiO4-Ca3(PO4)2 solid solution in the phosphorus-rich phase and the value of coefficient n decreases from 20 to 1 with increasing the Fe2O3 addition amount from 5 g to 30 g. With increasing the Fe2O3 addition amount, the oxygen potential and activity at the interface between the slag and hot metal increase. When the oxygen potential and the oxygen activity at the interface are greater than 0.72×10-12 and 7.1×10-3, respectively, the dephosphorization ratio begins to increase rapidly. With increasing the Fe2O3 addition amount to 30 g, the ratio of the Fe2O3 addition amount to theoretical calculation consumption is around 175%, and the dephosphorization ratio reaches the highest value of 83.3%.

In this part of the series of two papers, we extend the theorems discussed in part I for infinite series. We then use these theorems to develop distinct novel results involving the Hurwitz zeta function, Riemann zeta function, Polylogarithm and Fibonacci numbers. In continuation, we obtain some zeros of the newly developed zeta functions and explain their behaviour using plots in complex plane. Furthermore, we provide particular cases for the theorems and corollaries which show that our results generalise the currently available functions and series such as the Riemann zeta function and the geometric series. Finally, we provide four miscellaneous examples to showcase the vast scope of the developed theorems.

Low 25 OH vitamin D (25(OH)D) in preterm infants is a risk factor of bronchopulmonary dysplasia (BPD), but increased supplementation failed to demonstrate beneficial effect on BPD. In neonatal animal models, deficiency and excessive vitamin D exposure have been associated with increased mortality and lung histological alterations evocative of BPD. Our hypothesis is that 25(OH)D levels ≥ 120nmol/L is also a risk factor for BPD or death. This retrospective single-center cohort study included all infants born <31 weeks gestational age without major malformation with at least a determination of 25(OH)D <36 weeks corrected age and no determination <50 nmol/L. Routine 25(OH)D determination was performed at 1 month and monthly thereafter. A total of 175 infants were included. Infants with BPD or who died had a significantly lower term and weight, but a similar frequency of 25(OH)D ≥120nmol/L (50.5% vs 43.9%, p=0.53). The logistic regression identified weight (OR 0.997, 95%CI [0.995-0.998]) and term (OR 0.737, 95%CI [0.551-0.975]) as significantly associated with BPD or death; the occurrence of excessive 25(OH)D was not significantly associated (OR 1.029, 95%CI [0.503-2.093]). The present study did not demonstrate any significant association between excessive 25(OH)D after one month of age and BPD or death.

An accurate flux measurement of low-energy charged particles trapped in the magnetosphere is necessary for space weather characterization and to study the coupling between the lithosphere and magnetosphere, which allows for the investigation of the correlations between seismic events and particle precipitation from Van Allen belts. In this work, the project of a CubeSat space spectrometer, the Low-Energy Module (LEM), is shown. The detector will be able to perform an event-based measurement of the energy, arrival direction, and composition of low-energy charged particles down to 0.1 MeV. Moreover, thanks to a CdZnTe mini-calorimeter, the LEM spectrometer also allows for photon detection in the sub-MeV range, joining the quest for the investigation of the nature of Gamma-ray bursts. The particle identification of the LEM relies on the ΔE−E technique performed by thin silicon detectors. This multipurpose spectrometer will fit within a 10 × 10 × 10 cm3 CubeSat frame, and it will be constructed as a joint project between the University of Trento, FBK, and INFN-TIFPA. To fulfil the size and mass requirements, an innovative approach, based on active particle collimation, was designed for the LEM; this avoids the heavy/bulky passive collimators of previous space detectors. In this paper, we will present the LEM geometry, its detection concept, the results from the developed GEANT4 simulation, and some characterisations of a candidate silicon detector for the instrument payload.

Tropical rock lobsters (Panulirus ornatus) are a highly cannibalistic species with intermoult animals predominantly attacking animals during ecdysis (moulting). Rapid, positive characterisation of pre-ecdysis lobsters may open a pathway to disrupt cannibalism. Ecdysial suture line development is considered for pre-ecdysis recognition with suture line definition compared for lobsters emerged and immerged, using white, near ultraviolet (365 nm), near infrared (850 nm) and spe-cialty Osram SFH 4737 broadband IR LEDs against a reference of intermoult lobsters with no suture line development. An alternative pre-ecdysis recognition strategy used a novel low-cost spectral camera composed of the Sony IMX219, AMS AS7265x spectral sensors and Osram SFH 4737 broadband infrared LEDs. Images and data using the novel low-cost spectral camera was acquired from intermoult, pre-ecdysis, and post-ecdysis lobsters. Compared with the white light appear-ance, suture line definition was enhanced under 850 nm, 365 nm, and SFH 4737 LEDs for immerged lobsters, while the 850 nm LED achieved the best suture line definition of emerged lobsters. The spectral camera was unable to characterise pre-ecdysis. A least squares regression for binary classification decision boundary successfully separated 86.7% of post-moult lobsters. Achieving post-moult characterisation validated the speculative exploratory approach in developing this novel low-cost spectroscopy tool.

GNSS is nowadays a standard tool for monitoring and studying the Earth’s dynamic environment. However, the development of dense GNSS measurements remains limited in many experiments by the cost of geodetic-class equipments allowing to achieve the high precision required by many applications. Recently, multi-constellation, multi-frequency, low-power and, above all, less expensive GNSS electronic chips have become available. We present a prototype of a low-cost, open-source multi-GNSS station. Our prototype comprises a dual-frequency GNSS chip, a calibrated antenna, a Raspberry Pi card and a 4G key for data transmission. The system is easy to deploy in the field and allows precise positioning in real time and post-processing. We assess the performance of our prototype in terms of raw data quality, and quality of the obtained high rate and daily position one-year-long time series. Our results demonstrate a quality equivalent to geodetic-class equipment and better quality than other low-cost systems proposed so far.

The manufacturing geometrical variability in axial compressors is a stochastic source of uncertainty, implying that the real geometry differs from the nominal design. This causes the real geometry to lose the ideal axial symmetry. Considering the aerofoils of a stator vane, the geometrical variability affects the flow traversing it. This impacts the downstream rotor, especially when considering the aeroelastic excitation forces. Optical surface scans coupled with a parametrization method allow for acquiring the information relative to the real aerofoils geometries. The measured data are included in a multi-passage and multi-stage CFD setup to represent the mistuned flow. In particular, low excitation harmonics on the rotor vane are introduced due to the geometrical deviations of the upstream stator. The introduced low engine orders as well as their amplitude depend on the stator geometries and their order. A method is proposed to represent the phenomena in a reduced CFD domain, limiting the size and number of solutions required to probabilistically describe the rotor excitation forces. The resulting rotor excitation forces are reconstructed as a superposition of disturbances due to individual stator aerofoils geometries. This indicates that the problem is linear in in the combination of disturbances from single passages.

Disseminated or military tuberculosis (TB) is defined as the presence of at least two non-contiguous sites of Mycobacterium tuberculosis, occurring as a result of progressive primary infection, reactivation and spread of a latent focus or due to iatrogenic origin. Disseminated TB represents a life-threatening condition, especially in at-risk children and when the diagnosis and treatment are delayed. We report on a case of a 3-year old boy who presented with long-lasting unrecognised disseminated TB that was successfully managed in a low-resource setting.

This paper presents high-resolution digital measurements at low cost, combining oversample and averaging. Experiments of processing data between samples and between multiple temperature sensors in the same environment are conducted. They provide results with effective increase in the analog to digital converter bits, in correspondence with the minimization on the effects of noise. It is shown that averaging a set of small, low-cost sensors at a small microcontroller can give flexible access to improved measurement accuracy.

The production and secretion of very-low density lipoproteins (VLDL) by hepatocytes has a direct impact on liver fat content as well as the concentration of cholesterol and triglycerides in the circulation and thus affects liver and cardiovascular health, respectively. Importantly, excess caloric intake and lack of physical activity are associated with overproduction of VLDL, hepatic steatosis, and increased levels of atherogenic lipoproteins. Cholesterol as well as triglycerides in remnant particles after VLDL lipolysis are risk factors for atherosclerotic cardiovascular disease (ASCVD) and have garnered increasing attention over the last few decades. To date, however, increased risk of ASCVD is not the only concern when considering today’s cardiometabolic patients, as they often also suffer from hepatic steatosis. This notion highlights the importance of understanding the molecular regulation of VLDL biogenesis. Fortunately, there has been a resurgence of interest in the intracellular assembly, trafficking, degradation, and secretion of VLDL by hepatocytes, that has led to many exciting new molecular insights, the topic of this review. We think that increasing our understanding of the biology of this pathway will help improve the health of the cardiometabolic patient in the long term.

Two modal decomposition techniques, including proper orthogonal decomposition (POD) and dynamic mode decomposition (DMD), are used to identify the wake patterns past single and two crossing cylinders in 60° and 90° arrangements with gap ratio G = 4. The flow is simulated using direct numerical simulations (DNS) for Reynolds numbers Re = 100. The spatial scale of flow decreases with increasing modal frequency from the modal analysis. Two main modes are identified in the wake of the cylinders, namely spatially antisymmetric and symmetric modes. Antisymmetric and symmetric modes are related to cylinders’ vortex shedding and shedding vortices’ shift motion, respectively, whose frequencies are odd and even multiples of cylinders’ lift force frequency. In addition, a low-frequency mode concerning the shadowing effect of the downstream cylinder (DC) in 90° arrangement is found in the wake of the DC centre.

The present work aimed to validate a low-cost passive monitoring procedure. For its validation, the monitoring of atmospheric organic pollutants - polycyclic aromatic hydrocarbons (PAH) was carried out in a capital of the central-western region of Brazil. The sensors were fixed on poles intended for electrification during the dry season. After 15 days, samples were extracted by solvent extraction and analysed by High-Resolution Gas Chromatography with Flame Ionization Detector (HRGC-FID). For the validation of the procedure, PAHs monitored and standardised by the American Environmental Agency (EPA), a benchmark for environmental monitoring of air quality by several countries, were analysed. The results demonstrated that the low-cost passive monitoring method was effective in the quantification of PAH in the environment-air, capable of being used by countries that do not have many resources for monitoring air quality.

This article introduces the design and analysis of a slope detection circuit tailored for on-chip sensing of the load current in DC-DC converters. The novel indirect sensing approach is grounded in measuring the output voltage slope across the filtering capacitor during discharge phases. Consequently, this slope data can be effectively harnessed to control the converter switches. The slope detector circuit was designed in standard 65 nm CMOS technology using the nominal supply voltage of 1.2 V and can be used for current sensing within the range from one to hundreds of mA. Since the proposed circuit has mainly digital character, the robustness to process, temperature and supply voltage variations can be ensured rather conveniently.

Background: Protein CCDC186 is involved in the maturation of dense core vesicles in the trans-Golgi network in neurons and endocrine cells. To date, only one patient, within a large sequencing study of 1000 cases, and a single case report with variants in CCDC186 had previously been described. However, no functional studies in any of these two cases had been performed. Methods: Exome sequencing from one affected individual of each family was performed. In addition, Sanger sequencing of the parents and one of the affected siblings was also performed. CCDC186 protein was assessed in cultured fibroblasts or muscle tissue by western blot. Transcriptomic analysis was done by means of RNA sequencing. Results. We identified three patients from two gypsy families, unrelated to each other, with the same homozygous mutations in CCDC186 gene. Clinically, all patients presented with seizures, frontotemporal atrophy, hypomyelination, recurrent infections, and endocrine disturbances such as severe non ketotic hypoglycemia. Low levels of cortisol, insulin or growth hormone could only be verified in one patient. All of them had a neonatal onset and died between 7 months and 4 years of age. WES identified a homozygous variant in CCDC186 gene (c.2215C>T, p.Arg739Ter) in the index patients of both families. Protein expression studies demonstrated that the CCDC186 was practically undetectable in fibroblasts and muscle tissue. These observations correlated perfectly with the transcriptomic analysis performed in fibroblasts in one of the patients, which showed a significant reduction of CCDC186 mRNA levels. Conclusion. Our study provides functional evidence that mutations in this gene have a pathogenic effect on the protein and reinforces CCDC186 as a new disease-associated gene. In addition, mutations in CCDC186 could explain the combined endocrine and neurologic alterations detected in our patients

This paper aims at trying to answer the question of whether a low cost drone equipped with a regular camera can serve as a simple device to estimate the size of objects. Ad-ditionally, it assesses if the accuracy of measurement is good enough for using a drone for measurements, relying solely on GPS position and camera. A review of the literature pertaining to ground object measurements was conducted. The availability of such in-struments was evaluated in terms of purchase and rental costs, the number of instru-ments on the market, and the time to obtain them. The most common measurement methods were considered and their unit costs were reviewed. The cost of professional surveying and measuring equipment was compared to the possibility of using low-cost, non-commercial drones to measure objects and surfaces. The quality of the images ob-tained was compared with high-resolution satellite systems. Is an ordinary drone with a standard camera suitable for length measurement without professional measuring equipment? Should the results be considered only in the category of size estimation?

One of the key issues in sustainable tourism research is the gap between tourists' expressed friendly attitudes towards sustainable behaviors and their actual behaviors. Although many "low-carbon" themed restaurants have emerged during the low-carbon transformation of the Chinese tourism industry, low-carbon food services have not been significantly improved. This study takes food as the entry point to explore tourists' behavior and attitudes towards low-carbon tourism in relation to food. We conducted two interviews. The first interview was a semi-structured contextual interview with 120 tourists who had experiences in food streets, aim-ing to identify the core user group: low-carbon attitude-friendly tourists with high-carbon food behaviors. The second interviews was an in-depth interview based on grounded theory with 29 core users, analyzing the four main reasons for their high-carbon food behaviors and their re-quirements for low-carbon food services in tourism. Based on this, we extracted four design ele-ments for low-carbon tourism food services: low-carbon information show service, low-carbon service product attractiveness improvement, low-carbon food environment atmosphere creation, and service providers' low-carbon behaviors. Through these four service elements, we constructed a low-carbon tourism food service design framework based on the core users' needs, discussed the mechanism of service elements, and provided service design suggestions accordingly. The re-search results serve tourism providers, low-carbon tourism researchers, and designers.

Chronic pain is a serious health concern and potentially debilitating condition, leading to anxiety, depression, reduced productivity and functionality, and poor quality of life. This condition can be even more detrimental and incapacitating in the pediatric patient population. In low and middle income countries (LMICs), pain services are inadequate or unavailable, leaving most of the world's pediatric population with chronic pain untreated. Many of these children in LMICs are suffering without treatment, and often die in pain. Awareness and advocacy for this population must be prioritized. We reviewed the available literature on the chronic pediatric pain burden in LMICs, barriers to treatments, and current efforts to treat these patients.

To investigate the structural behavior of simply supported concrete beams with steel and polypropylene fiber under low velocity impact loading. In all twenty-four beams (150X200X1800 mm) with simply supported boundary condition were modeled and analyzed using ABAQUS software. Steel and polypropylene fibers of aspect ratio of 60 and 231 respectively are used. The total volumes of fibers are maintained at 1% by volume of specimen. A 100 kg hammer with tip diameter 16 mm (hemispherical contact area = 201 mm2) with four different velocities (3.13 m/s, 4.42 m/s, 5.43 m/s and 6.11 m/s) were used in the analysis. It is observed that with the addition of hybrid fibers the deflection in beams was reduced. The beams with 1% PP and 0% steel fiber shows the maximum deflection values due to low modulus of elasticity. Beams with 0.9% steel and 0.1% polypropylene fibers was less affected in terms of deflection as compared to all other beams, it is due to presence of high tensile strength fibers.

Phenylketonuria is an inherited metabolic disorder that leads to neurobehavioral dysfunction. The main treatment is a low-phenylalanine diet and/or the cofactor tetrahydrobiopterin. Regular outpatient follow-up care and measurement of the phenylalanine level in the blood are required. We aimed to analyze the economic burden of phenylketonuria on families and the state. The pa-tients with phenylketonuria were divided into three groups according to their treatment: a low-phenylalanine diet group (n= 50), a tetrahydrobiopterin group (n= 44) and a group taking tetra-hydrobiopterin together with the diet (n= 25). A comparative cost analysis was carried out. The annual economic burden to the state was calculated to average €18801±15345 and was lowest in the diet group, then in the tetrahydrobiopterin group and highest in the tetrahydrobiopterin+diet group (p < 0.001). Out-of-pocket costs amounted to €1531±1173 per year, and indirect losses aver-aged €2125±1930 per year for all families. The economic loss was significantly lower in the fami-lies taking tetrahydrobiopterin than in the other groups (p=0.001). The combined use of medical nutrition and BH4 treatments has been shown to increase the economic harm to the state. Reim-bursing low-protein products and increasing the rate of patients eligible for financial allowances may reduce the economic harm to families.

In the field of delta-sigma modulators, reducing system power consumption without sacrificing accuracy has become a challenge. The summing circuit, as the main part of the cascade-of-integrator-in-feedforward delta-sigma modulator, consumes a significant amount of power in active summing. On the other hand, passive summing circuits have low power consumption but can cause attenuation in the summing results. This article proposes a low-power multi-bit delta-sigma modulator based on passive and attenuationless summation scheme. The summation circuit achieves multiplication of the voltage signal carried on the summation capacitor through bidirectional sampling technique, compensating for the inherent attenuation caused by passive summation, thus eliminating the need for active OTA to achieve perfect summation. A 2-order delta-sigma modulator based on 4-bit 1-order passive noise-shaping (NS) SAR quantizer is designed to verify the scheme. By combining a passive NS SAR as the 4-bit quantizer and the third-stage integrator of the system, and incorporating an energy-efficient cascode floating inverter amplifier (FIA) structure as the core active OTA, these elements have significantly enhanced the energy-efficiency of the modulator. Simulation results show that at a supply voltage of 1.2 V and a bandwidth of 20 kHz, the SNDR reaches 102.62 dB, power consumption is only 148.32 μW, and Schreier figure-of-merit (FoM) of SNDR is 183.92 dB.

The low-altitude quasi-periodic (LQP) E-region echoes observed with the upgraded HCOPAR located in Hainan Island of China (19.5°N, 109.1°E) are presented. With the interferometry technique, the interferometry equations can be developed to investigate the structures of the irregularities. The results show that the plasma structures of the LQP echoes with negative slope mainly drift southwestward almost horizontally, but they also drifted southeastward in some striations. According to the movement of the plasma structures, we find strong wind shear in the region where the LQP echoes are produced. Meanwhile, The periodicity of the LQP echoes may be related to the strength of the wind shear. It is proposed that the plasma structures are most likely produced by the Kelvin-Helmholtz instability.

Glucose is an important carbon sources for microbial growth, and its content in infertile soils is essential for the growth of the bacterium. Since the mechanism of oligotrophic bacterium adaptation in barren soils is unclear, the research employed RNA Seq technology to examine the impact of glucose concentration on the low nutrient bacteria BS-G1 in soil affected by desertification. RNA-Seq revealed that differentially expressed genes（DEG）histidine metabolism, glutamate synthesis, HIF-1 signalling pathway, sporulation, and TCA cycle pathway of BS-G1 were significantly enriched in 0.015 g/L glucose concentration, compared with 10 g/L glucose concentration. DEG amino acids system, two-component system, Metal Ion Transport, and nitrogen metabolism system of B. subtilis BS-G1 were significantly enriched in 5 g/L glucose concentration, compared with 10 g/L glucose concentration. In addition, The present study identified its regulation pattern and key genes under the low glucose environment (7 mRNAs, 16 sRNAs). This study primarily investigates the variances in the regulatory pathways of oligotrophic bacteria BS-G1, which holds substantial importance in comprehending the mechanism underlying the limited sugar tolerance of oligotrophic bacteria.

Regulatory monitoring networks are often too sparse to support community-scale PM2.5 exposure assessment while emerging low-cost sensors have the potential to fill in the gaps. Recent advances in air quality monitoring have produced portable, easy-to use, low-cost, sensor-based monitors, which has given a new dimension to the air pollutant monitoring and has democratized the air quality monitoring process by making monitors and results directly available at community level. This study used PurpleAir(c) sensors for PM2.5 assessment in California, USA. Evaluation of PM2.5 from sensors included Quality Assurance &amp; Quality Control (QAQC) procedures, assessment with respect to reference monitored PM2.5 concentrations, and formulation of a decision support system integrating these observations using geostatistical techniques. The hourly and daily average observed PM2.5 concentrations from PurpleAir monitors followed the trends of observed PM2.5 at regulatory monitors. PurpleAir monitored PM2.5 also captured the peak PM2.5 concentrations due to incidents like forest fire. In comparison with reference monitored PM2.5 levels, it was found that PurpleAir PM2.5 concentrations were mostly higher. The most important reason for PurpleAir higher PM2.5 concentrations was the inclusion of moisture or water vapor as aerosol in contrast to measurements of PM2.5 excluding water content in FEM/FRM and non-FEM/FRM monitors. On long term assessment (2016-2020), R2 was between 0.54 and 0.86 at selected collocated PurpleAir and regulatory monitors for hourly PM2.5 concentrations. Past research studies have been conducted for mostly shorter time periods (&lt;3-4 months) that resulted in higher R2 values between 0.80 to 0.98. This study aims to provide reasonable estimations of PM2.5 concentrations with high spatiotemporal resolutions based on statistical models using PurpleAir measurements. The methods of Kriging and IDW, geostatistical interpolation techniques, showed similar spatio-temporal patterns. Overall, this study revealed that low-cost, sensor based PurpleAir sensors could be effective and reliable tools for episodic and long-term ambient air quality monitoring.

Most of the fishing currently practiced in Japan is done by small vessels with a small number of fishermen (one or two). One of the most common fishing methods is longline fishing. However, this method requires the vessel to operate at a constant low speed because the depth of the hook must be kept constant while adjusting the speed of the fishing boat to the tidal current. In addition, because the vessel must maneuver and fish at the same time, automation is desired. Thus, we propose a robotic system that can control the depth of the trap at a constant depth even when the speed of the vessel and the current change, and that can successfully fish without the need for skilled fishermen. Fishing can be conducted regardless of the speed of the vessel, whereas currently it is controlled by the speed of the vessel and the tidal current. Therefore, it may contribute to proposing new fishing methods as well as the existing ones. This can contribute to the shortage of successors to the fishing industry and to the revitalization of the fishing industry.

The purpose of this project was to demonstrate the potential of converting an existing internal combustion engine for hydrogen operation at relatively low cost and to optimize the combustion process for ultra-low NOx emissions. The conversion has been carried out on a 450cc naturally aspirated single cylinder engine. The first baseline measurements and setup have shown lower NOx emissions than the baseline gasoline engine (without catalytic converter) for similar power output and engine efficiency. Further optimization of the combustion process allowed to achieve Euro VI and (latest European Commission proposal) Euro VII heavy-duty NOx limits without exhaust gas aftertreatment system (EATS) in steady state conditions. The concept is very promising and the knowledge gained should allow for further optimization to achieve near zero NOx emissions at high engine efficiency and power output with supercharging. It should also allow an efficient conversion of other engine types for different applications. In particular, a project with the aim to convert a heavy duty 6 cylinder engine intended for public transport buses has started. It follows a feasibility study which has shown the competitiveness of the hydrogen engine for this application.

The paper explores the potential of a low-cost advanced video-based technique for the assessment of structural damage induced to buildings by seismic loading. A low-cost high-speed video camera was utilized for motion magnification (MM) processing of footages of a two-story reinforced concrete frame building subjected to shaking table tests. The damage after seismic loading was estimated by analyzing the dynamic behavior (i.e. in terms of modal parameters) and the structural deformations of the building in the MM videos. The results by MM were compared for method validation to damage assessment obtained by the analyses of conventional accelerometers and high-precision optical markers tracked by a passive 3D motion capture system. Also, 3D laser scanning to obtain an accurate survey of the building geometry before and after the seismic tests was carried out. In particular, accelerometers were also processed and analyzed by using several stationary and non-stationary techniques with the aim to analyze the linear behavior of the undamaged structure and the nonlinear structural behavior during damaging shaking table tests. The proposed MM-based procedure provided accurate estimate of the main modal frequency and the damage location through the analysis of modal shapes, which were confirmed by advanced analyses of accelerometric data.

Methane is the main cause of sewer explosion accidents, and the available monitoring methods mainly use portable gas sensors for on-site detection. However, these methods cannot grasp the dynamic changes in methane in a sewer in real time or make better predictions of methane explosion accidents. Here, we present a low-power online monitoring system for sewer methane in order to ensure the safety of urban sewers. A low-power ultrasonic gas sensor was used to monitor the methane content in biogas. Due to the impacts of changes in CO2, temperature, and humidity in the sewer on the ultrasonic methane measurement results, a corresponding compensation method was proposed. The effectiveness of the compensation method was verified through experiments, which measured the methane concentration under different influences, and the methane values measured before and after compensation were compared. The power consumption was only 1.28 mW if the system worked in intermittent operation mode, and it could operate for about 1.5 years by selecting a lithium battery with a capacity of 5 A · H. The experimental results showed that the gas detection accuracy could meet the commercial requirements and had a high compensation for the impacts of carbon dioxide, temperature, and humidity.

The goal of classroom English instruction is to educate students on how to use the English language effectively for communication in any scenario. It is identified by presenting various teaching tactics and speaking activities to encourage students to participate more actively in conversations. The study intended to identify the problems in the speaking performance of Grade 8 Jade in Tagum City National High School. The study was conducted using a quantitative non-experimental descriptive survey method. Results revealed that the problems in speaking performance have garnered a mean of 3.20 (moderate) as descriptive equivalent and it was found out that the prevailing speaking problem is anxiety with a mean of 3.84, interpreted as high. Thus, an intervention program is designed to address the problems in the speaking performance of the respondents. This program is divided into two: Overcoming Speaking Anxiety Seminar-Workshop and Speaking Enhancement Activities.

Low back pain is a common problem in the active population, and the second reason for visiting a physician. In patients with lumbar disc protrusion, the nucleus pulposus bulges against the disc and the latter protrudes into the spinal column, but the annulus fibrosus remains intact. The purpose of this study was to prove that starting an early complex rehabilitation treatment results into pain and disability reduction, and increased muscle strength and mobility in patients with lumbar disc protrusions. We performed a prospective cohort study, enrolling 60 patients (25 men and 35 women) aged between 26 to 76 years, diagnosed with lumbar disc protrusion. Patients in the experimental group registered significant improvements in all studied variables (pain, mobility, muscle strength, disability) after 6 months of treatment. The results of our study suggest that, in the lumbar disc disease, a combined rehabilitation program may be more effective in terms of pain and disability reduction, if it starts early after diagnosis. The current study proves the importance of combining electrotherapy with hydrotherapy and physical therapy. Patients who received this treatment combination showed an extremely significant improvement in pain relief, and reduction of functional disability after 6 months of treatment.

Pepper plants experience complex environmental factors including abiotic and biotic stresses in field and the importance of climate changes including low and high temperatures has been emerged. Low temperature stress in the growth and development is one of the most critical issues, which directly impact on the crop yield and productivity of pepper plants. It is essential to select and breed low temperature-(LT) tolerant pepper (Capsicum annuum L.) cultivars. The research was performed to assess the agronomical traits of 39 pepper accessions belonging to chili and bell fruit types which cultivated two different night temperature set-points at 15°C for suboptimal temperature (CT) and at 10°C for low temperature (LT), respectively. Plant heights (PH) of most pepper accessions in LT were significantly decreased compared to those in CT. The stem diameter (SD) and the length of main axis (LMA) were various depending on the genotypes under LT. Moreover, the number of flowers (NFL), the total number of fruits (NFR), fruit yield (FY), fruit fresh weight (FFW), fruit length (FL), fruit diameter (FD), and the number of seeds in a fruit (NSF) were notably declined in LT compared to CT. The evaluated agronomical traits between LT and CT were further applied for the correlation analysis, the principal component analysis (PCA), and the hierarchical cluster analysis. Notably, FY trait was correlated with other reproductive traits including NFR, FFW, FD, and FL on positive directions and LT treated-39 pepper accessions were clustered into seven groups by the clustering analysis. The selected accessions were primarily involved with the positive trends with the reproductive index including NFR, FL, FD, and FW traits and would be used for pepper breeding programs on developing LT-tolerant cultivars.

(1) Background: Although manual therapy for pain relief has been used as an adjunct in treatments for chronic low back pain (CLBP), there is still the belief that a single session of myofascial release would be effective. This study aimed to investigate whether a single session of a specific technique reduces pain and disability. (2) Methods: This was a crossover clinical trial in which 41 participants over 18 years old with CLBP were randomly enrolled into 3 situations - experimental, placebo, control, in a balanced and cross-over manner. The subjects underwent a single session of myofascial release on thoracolumbar fascia and compare it with the control and placebo. Outcome were pain and functionality, evaluated using the numerical pain rating scale (NPRS), pressure pain threshold (PPT) and Oswestry (ODI). (3) Results: There was no effects between-, within-tests, and interaction for all the outcomes, i.e., NPRS (η 2 = 0.32, F = 0.48, p = 0.61), PPT (η2 = 0.73, F = 2.80, p = 0.06), ODI (η 2 = 0.02, F = 0.02, p = 0.97). (4) Conclusion: A single trial of thoracolumbar myofascial release technique was not enough to reduce pain and disability in subjects with CLBP.

Background: To examine the association between income levels and mortality rates in patients with chronic kidney disease. Methods: We analyzed data obtained from 3,172 patients with chronic kidney disease obtained from the Korean National Health Insurance claims database (2003–2009). Each patient was monitored until December 2010 or until death, whichever came first. Individual income was estimated from the national health insurance premium. Information on mortality was obtained from the Korean National Statistical Office. Cox proportional hazard models were used to compare mortality rates between different income groups after adjusting for possible confounding risk factors. Results: A low income was significantly associated with a high mortality rate after adjusting for covariates (adjusted HR 1.298 [1.082–1.556]). In addition, dialysis patients who had low incomes were more likely to have higher mortality rates compared to those in dialysis patients who had high incomes (adjusted HR 1.528 [1.122–2.082]). Conclusion: The findings of this study indicate that chronic kidney disease patients with low incomes have the highest mortality risk. Promotion of targeted policies and priority health services for patients with low incomes may help reduce the mortality rate in this vulnerable group.

To achieve efficient utilization of low-concentration mine gas, reduce resource waste, and alleviate environmental pollution, high-temperature oxidation of low-concentration gas at a concentration range of 1.00% to 1.50% that is directly discharged into the atmosphere during coal mine production was oxidized to recover heat for reuse. The gas oxidation equipment was improved for the heating process, and the safety of low-concentration gas oxidation under high-temperature environment was evaluated. Experimental results showed that the reactor could provide a 1000 ℃ high-temperature oxidation environment for gas oxidation after installing high-temperature resistant ceramics. The pressure variation curves of the reactor with air and different concentrations of gas were similar. Due to the thermal expansion, the air pressure slightly increased and then returned to normal pressure. In contrast, the low-concentration gas exhibited a stable pressure response in the high-temperature environment of 1000 ℃. The outlet pressure was significantly greater than the inlet pressure, and the pressure difference between the inlet and outlet exhibited a trend to increase with the gas concentration. The explosion limit varied with the temperature and the blend with oxidation products. The ratio of measured gas pressure to air pressure after oxidation was below the explosion criterion, indicating that the measured concentration gas is still safe after the shift of explosion limit, which provides a safe concentration range for efficient use of low-concentration gas in the future.

The establishment of low carbon assessment initiatives is a crucial task especially at the city level. The determination of which source of carbon contributed more require robust data set and strategic approach. Hence, by using the campus as a small city approach, the establishment of carbon assessment and its’ reduction initiatives was required to keep track of the hotspot of the carbon source. The substantial amount of carbon source from campus operations such as energy consumption in the building, waste generation, and water consumption were identified. Moreover, as institutions of higher education, the execution of low carbon campus was initiated structurally involves the triangulation of research activities, teaching & learning and as well as campus operations or known as campus living lab approach. The application of low carbon cities framework, LCCF and assessment system enables to strategize the low carbon campus initiatives through the use of carbon footprint concept and the LCCF carbon track.

This paper deals with a non-contact method to identify the aerodynamic propeller parameters of the Parrot AR.Drone quadrotor. The experimental set consists in a camera recording the vehicle flights, the audio signal is extracted and is used a spectrogram analysis to estimates the propeller velocity. First, the aerial vehicle takes off and starts a hovering maneuver. The experiment is repeated with different additional masses attached to its rigid body. If the weight over the UAV increases/decreases, then the propeller must rotates faster/slower to produce a higher/lower thrust, and consequently, the sound frequency increases/decreases. Finally, this proposition is validated experimentally, and the estimated velocity is used to identify the quadrotor thrust parameters.

Introduction: We investigated the potential effect of smoking on pathological staging in clinically low-risk patients. Material-Methods: Data of 59 patients who were diagnosed with a bladder tumor for the first time and had a single lesion radiologically and endoscopically smaller than 3 cm were investigated, retrospectively. A total of 33 patients who currently smoke or smoked were classified as ever smokers group and 26 patients who did not ever smoke were classified as never smokers group. Pathological diagnoses of the patients in both groups were compared. Results: A total of 9 patients (27.3%) in ever smokers group and 18 patients (69.2%) in never smokers group had Ta disease (p<0.05). Morover, 19 patients (57.6%) in ever smokers group and 5 patients (19.2%) in never smokers group had T1 disease (p<0.05). The number of patients with low grade (LG) tumor were 8 (24.2%) and 19 (73.1%) in ever smoking and never smoking groups, respectively (p<0.05). The number of patients with high grade (HG) tumor were 25 (75.8%) and 7 (26.9%) in ever smoking and never smoking groups, respectively (p<0.05). Ta HG was detected in 9 (27.3%) patients in ever smoking group. In contrast, no patients in never smoking group had Ta HG disease (p<0.05). The number of patients with T1 HG was 17 (51.5%) in ever smoking group and 2 (7.69%) in never smoking group (p<0.05). Conclusion:Smoking seems to associate with pathologically worse stage and grade in patients with primary, single, < 3cm bladder cancer.

AbstractWe investigated the effect of cigarette smoking on pathological staging in clinically low-risk patients. Data of 59 patients who were diagnosed with bladder tumor for the first time and had a single lesion radiologically and endoscopically smaller than 3 cm were investigated retrospectively. 33 patients who smoked were classified as Group I, and 26 patients who did not smoke were classified as Group II. Pathological diagnoses of the patients in both groups were compared. The mean age of the patients were 64.8 (20–86) years. In Group II, 5 (19.2%) were female and 21 (80.8%) were male (p < 0.05). Nine patients (27.3%) in Group I and 18 patients (69.2%) in Group II had Ta disease (p < 0.05). Nineteen patients (57.6%) in Group I and 5 patients (19.2%) in Group II had T₁ disease (p < 0.05). The number of patients with low grade (LG) tumor were 8 (24.2%) and 19 (73.1%) in Group I and in Group II, respectively (p < 0.05). The number of patients with high grade(HG) tumor were 25 (75.8%) and 7 (26.9%) in Group I and in Group II, respectively (p < 0.05). TaHG was detected in 9 (27.3%) patients in Group I. In contrast, no patients in Group II had TaHG disease (p < 0.05). The number of patients with T₁HG was 17(51.5%) patients in Group I and 2 (7.69%) patients in Group II (p < 0.05). Smoking is associated with pathologically HG and stage in patients with first time bladder tumor which is single and smaller than 3 cm.

Hyper-radiosensitivity (HRS) is the increased sensitivity to low doses of ionizing radiation observed in most cell lines. We previously demonstrated that HRS is permanently abolished in cells irradiated at a low dose rate (LDR), in a mechanism dependent on transforming growth factor β3 (TGF-β3). In this study, we aimed to elucidate the activation and receptor binding of TGF-β3 in this mechanism. T-47D cells were pre-treated with inhibitors of potential receptors and activators of TGF-β3, along with addition of small extracellular vesicles (sEVs) from LDR primed cells, before their radiosensitivity was assessed by the clonogenic assay. The protein content of sEVs from LDR primed cells was analyzed with mass spectrometry. Our results show that sEVs contain TGF-β3 regardless of priming status, but only sEVs from LDR primed cells remove HRS in reporter cells. Inhibition of the matrix metalloproteinase (MMP) family prevents removal of HRS, suggesting an MMP-dependent activation of TGF-β3 in the LDR primed cells. We demonstrate a functional interaction between TGF-β3 and activin receptor like kinase 1 (ALK1), by showing that TGF-β3 removes HRS through ALK1 binding, independent of ALK5 and TGF-βRII. These results are an important contribution to a more comprehensive understanding of the mechanism behind TGF-β3 mediated removal of HRS.

The goal of this paper is to present a low-cost, low-power prototype of a pulsed Ultra Wide Band UWB) oscillator and an UWB elliptical dipole antenna integrated on the same Radio Frequency (RF) Printed Circuit Board (PCB) and its digital control board for Real Time Locating System (RTLS) applications. The design is compatible with IEEE 802.15.4 high rate pulse repetition UWB standard being able to work between 6 GHz and 8.5 GHz with 500 MHz bandwidth and with a pulse duration of 2 ns. The UWB system has been designed using the CST Microwave Studio transient Electro-Magnetic (EM) circuit co-simulation method. This method integrates the functional circuit simulation together with the full wave (EM) simulation of the PCB’s 3D model allowing fast parameter tuning. The PCB has been manufactured and the entire system has been assembled and measured. Simulated and measured results are in excellent agreement with respect to the radiation performances as well as the power consumptions.

With the widespread use of new equipment such as distributed photovoltaics, distributed energy storage, electric vehicles, and distributed wind power, the control of low-voltage distribution networks (LVDNs) has become increasingly complex. Acquiring the most recent topological structure is essential for conducting accurate analysis and real-time control of LVDNs. The signal-injection-based topology identification algorithm is favored for its speed and efficiency. This study proposes a new signal-injection-based topology identification algorithm aimed at solving the issues of reduced completeness and correctness of identification caused by missing feature signal records (FSRs). By analyzing the correlations between FSRs of different positions, the algorithm employs vertical and horizontal completion methods to effectively address missing data, combined with inclusion detection algorithms, to identify the topology of LVDNs. Based on the study of actual LVDN data, the results indicate that the algorithm not only significantly improves the completeness and correctness of topology identification for LVDNs but can also increase the number of devices in operation by evaluating the status of topological equipment, further enhancing the topology identification performance.

In the process of climate change mitigation and adaptation, the focus on climate risk driven by transition innovations has received widespread attention from governments, regulators, and investors. Based on the identification of low-carbon patents through the Green and Low-carbon Technology Inventory in China, this study constructs low-carbon innovation measurements of listed firms in China from 2015 to 2021. Then, an empirical model is used to investigate the impact and mechanism of climate transition innovations on the default risk. The baseline regression model shows that low-carbon innovations can mitigate the default risk of listed firms. Moreover, our findings are supported by instrumental variable regressions that use the time costs of innovation. Finally, the mediation effect demonstrates that investor attention, total factor productivity, and technology spillovers are paths through which transition innovations can affect the default risk. This study reveals that low-carbon technological advances have a positive effect on climate transition risks.

This review provides a comprehensive and updated information on chalcones, presenting their sources, methods of identification and properties putting emphasis on applications in agricultural industry. Vast exploitation of synthetic pesticides led to the weed and pest resistance issue, causing economic loss but more importantly health risk due to pesticide overuse. Because one of the aim of the European Green Deal 2030 is the Farm to Fork strategy which targets on reducing by 50% the use of chemical pesticides by 2030, and push towards natural pesticides which are more environmentally friendly and restore natural resources, chalcones and their derivatives seem to fit perfectly. They have herbicidal, fungicidal, bactericidal and antiviral properties. Moreover, chalcones are naturally occurring substances, known for their favorable health effect for years, working on many areas. This review is complementary to the previous ones describing chalcones use in agriculture, updates them but additionally shows methods of detection.

Public housing stock, called Social Housing, in Italy developed between the 1950s and the 1980s. As of today, the first residential developments are almost nearing their end-of-life age, in need of urgent and intensive renovation. The European Commission, with the Renovation Wave, has set a goal of doubling the rate of building renovation over the next 10 years, reducing emissions, improving energy performance, and promoting decarburization. Renovation interventions, including structural, functional, energy, plant upgrading, etc., are to be preferred over integral demolition and reconstruction interventions, which have significant repercussions in terms of managerial and social discomfort. The case studies examined concern renovation interventions aimed at energy efficiency, functional adaptation of housing as well as facade restyling. The design variants analyzed were evaluated in terms of CO2e emissions, according to LCI (Life Cycle Inventory) and EPD (Environmental Product Declaration) approaches. This approach has a twofold purpose: to propose design guidelines, with low CO2e emissions, through hypotheses of variants to the case studies, and to propose, to the Economic Operators, economically advantageous bidding scenarios, in the procurement process.