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Preprint ARTICLE | doi:10.20944/preprints202308.1352.v1

Oral Iron Absorption of Ferric Citrate Hydrate and Hepcidin-25 in Hemodialysis Patients: A Prospective, Multicenter, Observational Riona-Oral Iron Absorption Trial

Naohisa Tomosugi, Yoshitaka Koshino, Chie Ogawa, Kunimi Maeda, Noriaki Shimada, Kimio Tomita, Shoichiro Daimon, Tsutomu Shikano, Kazuyuki Ryu, Toru Takatani, Kazuya Sakamoto, Satonori Ueyama, Daisuke Nagasaku, Masato Nakamura, Shibun Ra, Masataka Nishimura, Chieko Takagi, Yoji Ishii, Noritoshi Kudo, Shinsuke Takechi, Takashi Ishizu, Takamoto Yanagawa, Masamichi Fukuda, Yutaka Nitta, Takayuki Yamaoka, Taku Saito, Suzuko Imayoshi, Momoyo Omata, Joji Oshima, Akira Onozaki, Hiroaki Ichihashi, Yasuhisa Matsushima, Hisahito Takae, Ryoichi Nakazawa, Koichi Ikeda, Masato Tsuboi, Keiko Konishi, Shouzaburo Kato, Maki Ooura, Masaki Koyama, Tsukasa Naganuma, Makoto Ogi, Shigeyuki Katayama, Toshiaki Okumura, Shigemi Kameda, Sayuri Shirai

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: oral iron absorption; ferric citrate hydrate; hemodialysis; hepcidin-25; iron shift

Online: 18 August 2023 (11:20:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0137.v1

Follow the Water in Its High-Subcritical State

Marie-Paule Bassez

Subject: Chemistry And Materials Science, Physical Chemistry Keywords: anoxic iron oxidation; abiogenic ferric iron; high-subcritical water; alkaline; ferric oxides; ferric silicates; amorphous silica; origin of life; fluid inclusions; geobiotropy

Online: 8 October 2018 (10:42:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0435.v1

The Magnetosome Protein, Mms6, is a Lipid-Activated Ferric Reductase

Dilini Singappuli-Arachchige, Shuren Feng, Lijun Wang, Pierre E. Palo, Samuel O. Shobade, Michelle Thomas, Marit Nilsen-Hamilton

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Mms6; ferric reductase; lipid; bicelles

Online: 28 July 2022 (09:00:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2108.v1

Nutritional Performance of Five Citrus Rootstocks under Different Fe Levels

Maribela Pestana, Pedro García-Caparros, Teresa Saavedra, Florinda Gama, Javier Abadía, Amarilis de Varennes, Pedro José Correia

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Fe-chlorosis; ferric-chelate reductase; mineral composition

Online: 31 July 2023 (11:19:47 CEST)

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Working Paper ARTICLE

Ferric Oxide Containing Waterworks Sludge Reduces Emissions of Hydrogen Sulfide in Biogas Plants and the Needs for Virgin Chemicals

Tobias Persson, Kenneth M. Persson, Jenny Åström

Subject: Engineering, Automotive Engineering Keywords: biogas digestion; hydrogen sulfide; ferric oxide; waterworks sludge)

Online: 25 May 2021 (14:15:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0019.v1

Influences of Etchants on Etched Surfaces of High-Strength and High Conductivity Cu Alloy of Different Processing States

Jinyang Fang, Qingke Zhang, Xinli Zhang, Feng Liu, Chaofeng Li, Lijing Yang, Cheng Xu, Zhenlun Song

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Cu alloy; Etching; Ferric chloride; Copper chloride; Surface morphology; Roughness

Online: 1 April 2024 (10:07:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1984.v1

Preoperative Intravenous Ferric Carboxymaltose Improves Recovery from Anemia in Patients Undergoing Revision Joint Arthroplasty: A Randomized Controlled Trial

Hong Yeol Yang, Kyung soon Park, Hyun Ho Shin, Ji Hoon Choi, Jong Keun Seon

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: revision joint arthroplasty; iron supplementation; ferric carboxymaltose; hemoglobin; iron metabolism

Online: 26 December 2023 (11:00:22 CET)

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(1) Background: Ferric carboxymaltose (FCM) is an intravenous (IV) high-dose iron that is effective in the treatment of iron deficiency anemia. This study was to determine if preoperative IV FCM administration could improve recovery from postoperative anemia in patients undergoing revision total joint arthroplasty. (2) Methods: This prospective randomized controlled study analyzed 82 patients undergoing revision total joint arthroplasty during a single hospitalization. Patients in the iron group (n = 41) were administered 1000 mg of IV FCM two weeks preoperatively, while those in the control group (n = 41) were not. Moreover, patients with anemia defined as a preoperative suboptimal Hb concentration <13.0 g/dl were compared according to IV FCM administration. The absolute Hb levels and changes in Hb levels, iron profiles, transfusion rate, and EuroQOL 5-dimension (EQ-5D) scores were compared. (3) Results: There were no significant differences in recovery of Hb levels at each timepoint between the two groups; however, the changes in Hb levels from baseline to four weeks postoperatively showed marginally significant differences favoring the iron group (p = 0.052). However, for preoperatively anemic patients, the change in hemoglobin (Hb) levels between baseline and four weeks postoperatively was significantly better in the iron group than in the control group (iron group [n = 26], −0.3 ± 0.7 g/dL vs. control group [n = 27], −0.9 ± 0.8 g/dL; p = 0.040), although the absolute Hb levels, transfusion rates, and patient quality of life were comparable (all p > 0.05). The iron group showed improved iron metabolite levels including serum ferritin and transferrin saturation four weeks postoperatively, and no adverse events associated with IV FCM administration occurred in either group. (4) Conclusions: Preoperative IV FCM in anemic individuals undergoing revision joint arthroplasty was effective in accelerating recovery from surgery-related anemia by improving Hb levels without any adverse events, despite similar actual Hb levels between the groups. Our findings are clinically relevant and can facilitate determination of the suitability of IV FCM as a safe and reliable protocol for iron supplementation for anemia correction.

Preprint ARTICLE | doi:10.20944/preprints202011.0146.v4

The Role of Divalent Transition Metal Ions in the Binding of Fur Dimer to DNA: Binding of Mn²⁺ and Co²⁺ to EC Fur dimer-DNA Complex

Mazen Hamed, Salih Jabour

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ferric Uptake Regulation; Fur, Iron(II), Molecular dynamics; DNA; protein

Online: 10 November 2020 (12:23:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0056.v1

Rapid Removal of Azophloxine via Catalytic Degradation by A Novel Heterogeneous Catalyst under Visible Light

Di Wu, Kequan Xia, Chengzhu Fang, Xuegang Chen, Ying Ye

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: peroxymonosulfate; ferric alginate; activated carbon fiber; visible radiation; heterogeneous photocatalysis

Online: 7 January 2020 (10:32:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0113.v1

Entomopathogenic Fungi-Mediated Solubilization and Induction of Fe related Genes in Melon and Cucumber Plants

Fabián García-Espinoza, Enrique Quesada-Moraga, María José García del Rosal, Meelad Yousef-Yousef

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Entomopathogenic fungi; Growth promoters; Nutrient Solubilization; Bioavailability; Iron acquisi-tion genes; ferric reductase activity

Online: 7 February 2023 (02:54:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0252.v1

Iron Depletion Reduces Abce1 Transcripts While Inducing the Mitophagy Factors Pink1 and Parkin

Jana Key, Nesli Ece Sen, Aleksandar Arsovic, Stella Krämer, Robert Hülse, Suzana Gispert-Sanchez, Georg Auburger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ferric ammonium citrate; deferoxamine; 2,2′-bipyridine; iron homeostasis; ISC; mitochondrial clearance; longevity; starvation; Parkinson’s disease

Online: 22 October 2019 (05:01:43 CEST)

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Lifespan extension was recently achieved in Caenorhabditis elegans nematodes by mitochondrial stress and mitophagy, triggered via iron depletion. Conversely in man, deficient mitophagy due to Pink1/Parkin mutations triggers iron accumulation in patient brain and limits survival. We now aimed to identify murine fibroblast factors, which adapt their mRNA expression to acute iron manipulation, relate to mitochondrial dysfunction and may influence survival. After iron depletion, expression of the plasma membrane receptor Tfrc with its activator Ireb2, the mitochondrial membrane transporter Abcb10, the heme-release factor Pgrmc1, the heme-degradation enzyme Hmox1, the heme-binding cholesterol metabolizer Cyp46a1, as well as the mitophagy regulators Pink1 and Parkin showed a negative correlation to iron levels. After iron overload, these factors did not change expression. Conversely, a positive correlation of mRNA levels with both conditions of iron availability was observed for the endosomal factors Slc11a2 and Steap2, as well as for the iron-sulfur-cluster (ISC)-containing factors Ppat, Bdh2 and Nthl1. Positive correlation only after iron depletion was observed for the iron export factor Slc40a1, mitochondrial iron transporters Slc25a28, Abcb7 and Abcb8, mitochondrial ISC-containing factors Glrx5, Nfu1, Bola1 and Abce1, cytosolic Aco1 and Tyw5, as well as nuclear Dna2, Elp3, Pold1 and Prim2. The latter are regulators of nucleotide synthesis and DNA quality control, which have known importance for growth and lifespan. The only Pink1-/- triggered transcript modulation was the reduced expression of the ISC-containing ribosomal factor Abce1. These mammalian findings support previous fly data that Pink1 influences co-translational quality control via Abce1, as well as mitophagy. Our findings provide the first systematic survey how iron dosage triggers homeostatic transcriptional regulations and elucidate how iron deprivation results in mitophagy.

Preprint REVIEW | doi:10.20944/preprints202311.1158.v1

Parenteral Iron Therapy for Pediatric Patients

Elpis Mantadakis, Sonia Alexiadou, Panagiota Zikidou

Subject: Medicine And Pharmacology, Hematology Keywords: iron deficiency; iron deficiency anemia; intravenous iron; iron sucrose; ferric carboxymaltose; iron isomaltoside; inflammatory bowel diseases

Online: 20 November 2023 (02:41:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0022.v1

Development of Phaleria macrocarpa (Scheff.) Boerl Fruits Using Response Surface Methodology On Phenolic, Flavonoid and Antioxidants Properties

Khurul Ain Mohamed Mahzir, Siti Salwa Abdul Gani, Nor Fadzillah Mokhtar

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Phaleria macrocarpa; extraction; free radical scavenging activity (DPPH); ferric ion reducing power assay (FRAP); total phenolic content (TPC); total flavonoid content (TFC); response surface methodology (RSM)

Online: 3 January 2018 (10:15:16 CET)

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