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Preprint REVIEW | doi:10.20944/preprints202211.0160.v1

Chondroitin Sulfate Proteoglycan 4 as a Marker for Aggressive Squamous Cell Carcinoma

Kathryn Chen, Joel Yong, Roland Zauner, Verena Wally, John Whitelock, Mila Sajinovic, Zlatko Kopecki, Kang Liang, Kieran Scott, Albert Sleiman Mellick

Subject: Life Sciences, Molecular Biology Keywords: chondroitin sulfate proteoglycan; cutaneous squamous cell carcinoma; head and neck squamous cell carcinoma; cancer biomarker; gene expression.

Online: 9 November 2022 (01:08:57 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202004.0150.v1

Cytoplasmic Increase of Hsp70 Protein: Potential New Biomarker of Early Infiltration of Cutaneous Squamous Cell Carcinoma Arising from Actinic Keratosis

Montserrat Fernandez-Guarino, José Javier Zamorano León, Antonio José López Farré, Maria Luisa Gonzalez Morales, Ana Isabel Sanchez Adrada, Jose Barrio Garde, Jose Antonio Arias Navalon, Pedro Jaen-Olasolo

Subject: Medicine & Pharmacology, Dermatology Keywords: actinic keratosis; cutaneous squamous cell carcinoma; cytoplams; skin cancer; heat shock protein

Online: 9 April 2020 (12:21:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0393.v1

Primary Cutaneous Anaplastic Large Cell Lymphoma (pcALCL) in Elderly, the Importance of a Sport Activity Training

Antonello Sica, Paola Vitiello, Andrea Ronchi, Beniamino Casale, Armando Calogero, Evangelista Sagnelli, Gilca Costa Nachtigal, Teresa Troiani, Renato Franco, Giuseppe Argenziano, Elvira Moscarella, Caterina Sagnelli

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cutaneous lymphoma in elderly; skin tumors; T-cell lymphomas; sport activity training

Online: 30 December 2019 (05:43:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0136.v1

Altitude Effect on Cutaneous Melanoma Epidemiology in the Veneto Region (Northern Italy): A Pilot Study

Paolo Del Fiore, Irene Russo, Alessandro Dal Monico, Jacopo Tartaglia, Beatrice Ferrazzi, Marcodomenico Mazza, Francesco Cavallin, Saveria Tropea, Alessandra Buja, Rocco Cappellesso, Lorenzo Nicolè, Vanna Chiarion-Sileni, Chiara Menin, Antonella Vecchiato, Angelo Paolo Dei Tos, Mauro Alaibac, Simone Mocellin

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cutaneous melanoma; altitude; coast-plain-hill gradient

Online: 14 April 2022 (14:54:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0309.v1

Transcriptional Analysis-Based Alterations Affecting Neuritogenesis of the Peripheral Nervous System in Psoriasis

Dóra Romhányi, Kornélia Szabó, Lajos Kemény, Endre Sebestyén, Gergely Groma

Subject: Medicine & Pharmacology, Pathology & Pathobiology Keywords: psoriasis; cutaneous nervous system; axon development; myelination

Online: 17 November 2021 (12:54:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0162.v1

Association of Circular RNA and Long Noncoding RNA Dysregulation to Clinical Response to Immunotherapy in Cutaneous Metastatic Melanoma

Javier Oliver, Juan Luis Onieva, Maria Garrido-Barros, Miguel Berciano-Guerrero, Alfonso Sánchez, Maria Jose Lozano, Angela Farngren, Martina Álvarez, Beatriz Martinez-Galvez, Elisabeth Pérez, Emilio Alba, Manuel Cobo-Dols, Antonio Rueda-Dominguez, Isabel Barragán

Subject: Life Sciences, Genetics Keywords: Circular RNA; Cutaneous Melanoma; Immunotherapy; metastasis; LncRNA; ecRNA

Online: 11 July 2022 (14:14:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0128.v1

Rapid Response of Refractory Systemic Lupus Erythematosus Skin Manifestations to Anifrolumab – A Case-Based Review of Clinical Trial Data Suggesting A Domain-Based Therapeutic Approach

Marlene Plüß, Silvia Piantoni, Chris Wincup, Peter Korsten

Subject: Medicine & Pharmacology, Other Keywords: systemic lupus erythematosus; anifrolumab; interferon; cutaneous lupus erythematosus

Online: 10 May 2022 (07:45:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0236.v1

Canine and Feline Cutaneous Lymphocytosis: Reactive Process or Indolent Neoplastic Disease?

Francesco Albanese, Francesca Abramo, Michele Marino, Maria Massaro, Laura Marconato, Lucia Minoli, Valeria Martini, Luca Aresu

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: cat; cutaneous lymphocytosis; dog; immunohistochemistry; lymphoma; PARR; skin

Online: 14 December 2021 (13:01:19 CET)

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Working Paper REVIEW

Cutaneous and Systemic Psoriasis: Classification Criteria and Personalized Treatment

Bing-Xi Yan, Xue-Yan Chen, Li-Ran Ye, Jia-Qi Chen, Min Zheng, Xiao-Yong Man

Subject: Medicine & Pharmacology, Allergology Keywords: Psoriasis; cutaneous psoriasis; systemic psoriasis; classification criteria; therapy

Online: 26 September 2020 (15:03:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0624.v1

Real Life Clinical Management and Survival in Cutaneous Malignant Melanoma: the Italian Clinical National Melanoma Registry (CNMR) Experience

Anna Crispo, Maria Teresa Corradin, Erika Giulioni, Antonella Vecchiato, Paolo Del Fiore, Paola Queirolo, Francesco Spagnolo, Vito Vanella, Corrado Caracò, Giulio Tosti, Elisabetta Pennacchioli, Giuseppe Giudice, Eleonora Nacchiero, Pietro Quaglino, Simone Ribero, Monica Giordano, Desire Marussi, Stefania Barruscotti, Michele Guida, Vincenzo De Giorgi, Marcella Occelli, Federica Grosso, Giuseppe Cairo, Alessandro Gatti, Daniela Massa, Laura Atzori, Nicola Calvani, Tommaso Fabrizio, Giuseppe Mastrangelo, Federica Toffolutti, Egidio Celentano, Mario Budroni, Sara Gandini, Carlo Riccardo Rossi, Alessandro A. E. Testori, Giuseppe Palmieri, Paolo A. Ascierto

Subject: Medicine & Pharmacology, Allergology Keywords: medical record systems; cutaneous malignant melanoma; survival analysis; immunotherapy

Online: 29 October 2020 (16:02:44 CET)

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Background: Cutaneous malignant melanoma (CMM) is one of the most aggressive types of skin cancer. Currently, innovative approaches such as target therapies and immunotherapies have been introduced in clinical practice for the treatment of metastatic CMM. Data of clinical trials and real life studies that evaluate the outcomes of these therapeutic associations are necessary to establish their clinical utility. The aim of this study is to investigate the types of oncological treatments employed in the real-life clinical management of patients with advanced CMM in several Italian centers which are part of the Clinical National Melanoma Registry (CNMR), and the oncological outcomes obtained. Methods: CNMR collects data of patients with a histologically confirmed diagnosis of primary CMM treated in one of the 38 Italian institutions (hospitals, research institutes, etc.) participating in the network. Melanoma-specific survival and Overall survival were calculated. Kaplan-Meier curves and medians of OS and 95% CI are presented overall and by immunotherapy and target treatments. The Log-rank test compared curves by treatments. Multivariate Cox regression models were used to estimate the hazard ratios adjusting for confounders and other prognostic factors. Results: The median follow-up time was 36 months (range 1.2-185.1). 787 CMM were included in the analysis with completed information about therapies.Global immunotherapy showed a significant improved survival compared with all other therapies (p=0.001). 75% was the highest reduction of death reached by nivolumab/pembrolizumab immunotherapy (anti-PD1 HR=0.25 95% CI 0.14-0.42), globally immunotherapy was significantly associated with improved survival, either for anti-CTL A4 monotherapy or combined with anti-PD1 (HR=0.47;95% CI 0.33-0.66 and HR=0.26; 95% CI 0.15-0.46, respectively). Conclusions: The nivolumab/pembrolizumab and the combination of ipilimumab can be considered the best therapy to improve survival in a real-world-population. The CNMR can complement clinical registries with the intent of improving cancer management and standardizing cancer treatment.

Preprint ARTICLE | doi:10.20944/preprints201902.0177.v1

Clinico-Histopathological and Immunohistochemistry Study of Ruminant’s Cutaneous Papillomavirus in Al-Muthanna Veterinary Hospital/ Iraq

Ahmed H. Al-Dabhawi, karima A. Al-Salihi, Ibrahim A. Erzuki, Tho Alfiqar H. Ali

Subject: Life Sciences, Virology Keywords: Bovine cutaneous papilloma, Iraq, Immunohistochemical (IHC), hyperkeratosis, p53 marker.

Online: 19 February 2019 (11:04:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0239.v1

Prognostic Value of the Intratumoral Lymphocyte to Monocyte Ratio and M0 Macrophage Enrichment in the Melanoma Immune Microenvironment

Neil Jairath, Mark Farha, Ruple Jairath, Paul Harms, Lam Tsoi, Trilokraj Tejasvi

Subject: Medicine & Pharmacology, Dermatology Keywords: Cutaneous Melanoma; Immunotherapy; Lymphocytes; Monocytes; Macrophages; RNAseq; tumor immune microenvironment

Online: 11 September 2020 (04:02:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0703.v1

Microfluidic and Lab-on-a-Chip Systems for Cutaneous Wound Healing Studies

Ghazal Shabestani Monfared, Peter Ertl, Mario Rothbauer

Subject: Biology, Anatomy & Morphology Keywords: Cell mogration; Cutaneous wound healing; Wound healing assay; lab-on-a-chip; Skin; Microvasculature; Microfluidics

Online: 27 April 2021 (10:17:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0020.v1

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling

Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N. Chamcheu, Abu Bakar Siddique, Melissa B. Bloch, Sergette Banang Mbeumi, Abiola S. Babatunde, Mohammad B. Uddin, Felicite K. Noubissi, Peter W. Jurutka, Yong-Yu Liu, Vladimir S. Spiegelman, G. Kerr Whitfield, Khalid A. El Sayed

Subject: Medicine & Pharmacology, Dermatology Keywords: Annona muricata; apoptosis; basal cell carcinoma; cutaneous squamous cell carcinoma; graviola; Hedgehog signaling pathway; natural products chemistry; non-melanoma skin cancer

Online: 1 June 2018 (13:00:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0158.v1

Cutaneous and Mucosal Manifestations Associated to Celiac Disease

Luis Rodrigo, Valia-Patricia Beteta, Nuria Álvarez, Celia Gómez de Castro, Álvaro de Dios, Laura Palacios, Jorge Santos-Juanes

Subject: Medicine & Pharmacology, Dermatology Keywords: celiac disease; dermatitis herpetiformis; alopecia areata; cutaneous vasculitis; urticaria; atopic dermatitis; psoriasis; recurrent aphtous ulceration; chronic ulcerative stomatitis; gluten-free diet

Online: 10 May 2018 (08:04:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0299.v1

Interactions of Human Dermal Dendritic Cells and Langerhans Cells Treated with Hyalomma Tick Saliva with Crimean-Congo Hemorrhagic Fever Virus

Sergio E. Rodriguez, Alexander J. McAuley, Aysen Gargili, Dennis A. Bente

Subject: Life Sciences, Virology Keywords: Crimean-Congo hemorrhagic fever virus; Crimean-Congo hemorrhagic fever; Hyalomma marginatum; human cutaneous immune response; Langerhans cells; dermal dendritic cells; tick-borne virus; tick-virus-host interface

Online: 19 June 2018 (11:50:54 CEST)

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