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Preprint REVIEW | doi:10.20944/preprints202307.1105.v1

The Role of Chronic Fatigue in Patients with Crohn’s Disease

Marcin Włodarczyk, Adam Makaro, Mateusz Prusisz, Jakub Włodarczyk, Marta Nowocień, Kasper Maryńczak, Jakub Fichna, Łukasz Dziki

Subject: Biology And Life Sciences, Life Sciences Keywords: Crohn’s disease; fatigue; pathophysiology; chronic fatigue syndrome

Online: 17 July 2023 (10:47:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0392.v1

Amani Zidan, Ahmed Awaisu, Maguy El-Hajj, Samya Al-Abdulla, Dianne Figueroa, Nadir Kheir

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Medication-related burden; Questionnaire; chronic disease conditions; adherence

Online: 25 June 2018 (14:35:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1162.v1

CfDNA and Caspase-3 Levels in Patients with Chronic Kidney Disease

Anna Clementi, Grazia Maria Virzì, Sabrina Milan Manani, Massimo De Cal, Giovanni Giorgio Battaglia, Claudio Ronco, Monica Zanella

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: cell free DNA, caspase-3, chronic kidney disease,

Online: 16 June 2023 (03:31:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0340.v1

The Efficacy and Safety of High Dose Cholecalciferol Therapy in Hemodialysis Patients

Agnieszka Tarasewicz, Michał Komorniczak, Agnieszka Zakrzewska, Bogdan Biedunkiewicz, Sylwia Małgorzewicz, Magdalena Jankowska, Katarzyna Jasiulewicz, Natalia Płonka, Małgorzata Dąbrowska, Alicja Dębska-Ślizień, Leszek Tylicki

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: vitamin D; cholecalciferol; 25-hydroxycholecalciferol, calcidiol; calcitriol; hemodialysis; parathyroid hormone; chronic kidney disease; chronic kidney disease–mineral; bone disorder

Online: 7 November 2023 (02:38:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0353.v1

Lactic Acidosis Associated with Metformin in Patients with Diabetic Kidney Disease: A Narrative Review

Fatkhu Rahman, Syahrul Tuba

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Diabetic; Chronic Kidney Disease; Metformin; Acidosis Lactate

Online: 28 February 2022 (09:28:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0028.v2

Motivating Diabetic and Hypertensive Patients to Engage in Regular Physical Activity: A Multi-Component Intervention Derived from the Concept of Photovoice

Angela Y. M. Leung, Pui Hing Chau, Isaac S. H. Leung, Michael Tse, Perick Lai Choi Wong, Wai Ming Tam, Doris Y. P. Leung

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: photovoice; chronic illness; physical activity; barriers; facilitator

Online: 2 April 2019 (07:48:28 CEST)

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Aims: A community-based multi-component intervention (increasing awareness of the importance of physical activity in chronic illness management through reading comic books, training regarding warm-up stretching exercises, identifying facilitators and barriers to exercise through photosharing, supporting self-reflection and development of action plans) was developed to promote physical activity (PA) among patients with diabetes and hypertension. This study aimed to evaluate the efficacy of this intervention on health behaviour (walking) and health outcomes. Design: A non-randomized controlled trial with waitlisted control and pre- and post-measures. Setting: Community centres for the elderly. Participants: A total of 204 older adults with diabetes and/or hypertension were recruited. They were assigned to either the intervention group (IG) or waitlisted to the control group (CG). Intervention: Under the supervision of a nurse, six weekly group meetings were arranged in community centres for the elderly in which the participants freely exchanged their views regarding the barriers and facilitators of regular physical activity. Participants were encouraged to take photos in their neighbourhood or at home and brought these photos to share at the group meetings. The photos showed both the barriers and the facilitators to PA. In the last meeting, each participant worked out a plan to perform PA in the coming four weeks. Measures: PA referred to the number of steps taken per day and it was measured by a Garmin Accelerometer at baseline, Week 6 and Week 10. Other measures included the nine-item Self-Efficacy Scale for Exercise - Chinese version (SEE-C), the 23-item Chinese Barriers to Exercise Scale and Senior Fitness Tests. Generalised Estimating Equations (GEE) models compared the outcomes over time between IG and CG. Results: A statistically significant difference in the changes in the average number of steps taken daily between the two groups at Week 10 (mean difference = 965.4; 95% confidence interval: 92.2, 1838.6, p = 0.030) was observed, although the difference at Week 6 was non-significant (mean difference = 777.6; 95% confidence interval: −35.3, 1590.5, p = 0.061). IG participants also showed significant improvements in lower body strength (mean difference = 0.967; 95% confidence interval: 0.029, 1.904, p = 0.043) and lower limb flexibility (mean difference = 2.068; 95% confidence interval: 0.404, 3.731, p = 0.015) at Week 10 compared to CG participants. Conclusion: This multi-component intervention improved the participants’ physical activity level and physical fitness, particularly in lower limb flexibility and body strength.

Preprint ARTICLE | doi:10.20944/preprints202309.1214.v1

Questionable Validity of Creatinine-Based eGFR in Elderly Patients

Dario Geißer, Lina Hetzel, Ralf Westenfeld, Fritz Boege

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: renal dysfunction; chronic kidney disease; CKD-stage; eGFR; creatinine; cystatin C

Online: 18 September 2023 (16:13:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0672.v1

Renal Biomarkers in Cardiovascular Patients with Acute Kidney Injury

Rolando Claure-Del Granado, Jonathan S. Chávez-Iñiguez

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Cardiorenal syndromes; Acute kidney injury; Biomarkers; Chronic kidney disease; Heart failure

Online: 21 April 2023 (05:26:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1623.v1

Prevalence of Type 1 and 2 Diabetes among Chronic Kidney Disease Patients and Laboratorial Differences between Them

Abdullah Shyah, Ahmad Almouselli, Taghreed Hmoud

Subject: Medicine And Pharmacology, Internal Medicine Keywords: diabetes; chronic kidney disease; diabetic nephropathy; MDRD

Online: 28 February 2024 (10:43:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0062.v1

Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

Marianne J. Middelveen, Eva Sapi, Jennie Burke, Katherine R. Filush, Agustin Franco, Melissa C. Fesler, Raphael B. Stricker

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Lyme disease; Borrelia burgdorferi; Tickborne disease; Chronic infection; Spirochete culture

Online: 8 March 2018 (07:08:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0448.v1

MERTK rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in HCV-Infected Patients: A Longitudinal Study

Maria Angeles Jimenez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Oscar Brochado-Kith, Juan José Sánchez-Ruano, Tomás Artaza-Varasa, Alicia Gómez-Sanz, Amanda Fernández-Rodríguez, Salvador Resino

Subject: Biology And Life Sciences, Virology Keywords: liver stiffness; MERTK; chronic hepatitis C; cirrhosis; SNPs

Online: 19 October 2018 (10:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0100.v1

Electrocardiogram, Echocardiogram and NT-proBNP in Screening for Thromboembolism Pulmonary Hypertension in Patients after Pulmonary Embolism

Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Iwona Dudzik-Niewiadomska, Michał Machowski, Marek Roik, Małgorzata Wiśniewska, Jan Siwiec, Izabela Magdalena Staniszewska, Piotr Pruszczyk

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: screening after pulmonary embolism; chronic thromboembolic pulmonary disease; chronic thromboembolic pulmonary hypertension; diagnostic work-up of post-pulmonary syndrome

Online: 9 October 2022 (02:09:20 CEST)

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Background: The annual mortality of patients with untreated chronic thromboembolism pulmonary hypertension (CTEPH) is approximately 50% unless a timely diagnosis is followed by adequate treatment. In pulmonary embolism (PE) survivors with functional limitation the diagnostic work-up starts with echocardiography. It is followed by lung scintigraphy and right heart catheterization. However, noninvasive test providing diagnostic clues to CTEPH, or ascertain this diagnosis as very unlikely, would be extremely useful since the majority of post PE functional limitations is caused by deconditioning. Methods: Patients after acute PE underwent a structured clinical evaluation with electrocardiogram, routine laboratory tests including NT-proBNP and echocardiography. The aim of study was to verify whether the parameters from echocardiographic or perhaps electrocardiographic examination and NT-proBNP concentration best determine the risk of CTEPH. Results: A total (n = 261, male n = 123) patients after PE were included into the study, in group of 155 patients (59.4%) with reported functional impairment 13 patients (8.4%) had CTEPH and 7 PE survivors had chronic thromboembolic pulmonary disease (CTEPD) (4,5%). Echo parameters differed significantly between CTEPH/CTEPD cases and other symptomatic PE survivors. Patients with CTEPH/CTEPD had also higher level of NT-proBNP (p = 0.022) but concentration of NT-proBNP above 125 pg/ml did not differentiate patients with CTEPH/CTEPD (p>0.05). Additionally, proportion of patients with right bundle brunch block registered in ECG was higher in group with CTEPH/CTED (23.5% vs. 5.8%, p = 0.034) but there were no differences between other ECG characteristics of right ventricle overload. Conclusion: Screening for CTEPH/CTEPD should be performed in patients with reduced exercise tolerance compared to pre PE period, It is not effective in asymptomatic PE survivors. Patients with CTEPH/CTED had predominantly abnormalities indicatingchronic thromboembolism in the echocardiographic assessment. NT-proBNP and electrocardiographic characteristics of right ventricle overload proved to be insufficient in predicting CTEPH/CTEPD development.

Preprint ARTICLE | doi:10.20944/preprints202312.0048.v1

Sa-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

Pasquale Esposito, Daniela Picciotto, Daniela Verzola, Giacomo Garibotto, Emanuele Luigi Parodi, Antonella Sofia, Francesca Costigliolo, Gabriele Gaggero, Valentina Zanetti, Michela Saio, Francesca Viazzi

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: senescence; cell; chronic kidney disease; kidney tubules

Online: 1 December 2023 (05:32:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1358.v1

A Study on Mortality Predictors in Hemodialysis Patients Infected with COVID-19: Impact of Vaccination Status

Voin Brkovic, Gorana Nikolic, Marko Baralić, Milica Kravljava, Marija Milinkovic, Jelena Pavlovic, Mirjana Lausevic, Milan Radovic

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Covid-19; vaccines; chronic kidney disease; hemodialysis; lymphocytopenia

Online: 22 November 2023 (07:39:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1434.v1

Exploring Chronic Patients' Views and Perceptions on Life Constraints and Self- Management Strategies. A Qualitative Study

Michael Rovithis, Sofia Koukouli, Alexios Dimitropoulos, Argyroula Kalaitzaki, Nikos Rikos, George Vasilopoulos, Aikaterini Papachristou, George Tsolas, Alexandra Tamiolaki, Eleni Tsapnidou, Anastasia Dimitrantzou, Dimitrios Katsiris, Elli Katsiri, Areti Stavropoulou

Subject: Public Health And Healthcare, Other Keywords: chronic disease; self-management; elder patients; qualitative study

Online: 21 June 2023 (08:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0940.v1

18 Months Follow-Up of Deep Molecular Response 4.5 (MR4.5) with Nilotinib in Patients with Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: A Prospective, Multi-Center Study in China

Bingbing Wen, Yuming Zhang, Haiqing Lin, Jin Lou, Chuangqing Tu, Yirong Jiang, Xiaolian Liu, Yan Chen, Huiqing He, Zelin Liu, Xiaoling Xie, Wangxiang Huang, Liping Pang, Xin Du

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: 18 months; deep molecular response; nilotinib; newly diagnosed; chronic-phase chronic myeloid leukemia

Online: 13 June 2023 (12:52:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1452.v1

Application of bioelectrical impedance analysis in nutritional management of patients with chronic kidney disease

Yanchao Guo, Meng Zhang, Ting Ye, Zhixiang Wang, Ying Yao

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: body composition; bioelectrical impedance analysis; chronic kidney disease; nutrition

Online: 21 August 2023 (09:57:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1436.v1

Cognitive Impairment and Brain Atrophy in Patients with Non-Dialysis and Dialysis Dependent Chronic Kidney Disease

Kazuhiko Tsuruya, Hisako Yoshida

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: brain atrophy; cognitive impairment; chronic kidney disease; dialysis; exercise

Online: 18 January 2024 (15:58:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0102.v1

Comparison of Surgical Risk Scores in a European Cohort of Patients with Advanced Chronic Liver Disease

Lidia Canillas, Amalia Pelegrina, Elena Colominas-González, Aina Salis, Cesar J. Enríquez-Rodríguez, Xavier Duran, Antonia Caro, Juan Álvarez, Jose A Carrión

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Cirrhosis; Advanced Chronic Liver Disease; Surgery; Postoperative risk; Mortality

Online: 4 September 2023 (07:24:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0381.v1

CLINICAL PROFILE OF PATIENTS WITH CORONARY TORTUOSITY AND ITS RELATION WITH CORONARY ARTERY DISEASE

Ankush Gupta, Prashant Panda, YASH SHARMA, Ashwin Mahesh, Prafull Sharma, Nalin Kumar Mahesh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronary tortuosity; myocardial ischemia; coronary artery disease; chronic stable angina.

Online: 25 June 2018 (11:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0205.v1

Different Lower Extremity Arterial Calcification Patterns in Patients with Chronic Limb-Threatening Ischemia Compared with Asymptomatic Controls

Louise CD Konijn, Richard AP Takx, Willem PThM Mali, Hugo TC Veger, Hendrik van Overhagen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic limb-threatening ischemia; peripheral arterial disease; calcification pattern

Online: 7 April 2021 (14:45:17 CEST)

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Objectives The most severe type of peripheral arterial disease (PAD) is critical limb ischaemia (CLI). In CLI, calcification of the vessel wall plays an important role in symptoms, amputation rate and mortality. However, calcified arteries are also found in asymptomatic persons (non-PAD patients). We investigated whether the calcification pattern in CLI patients and non- PAD patients are different and could possibly explain the symptoms in CLI patients. Materials and Methods 130 CLI and 204 non-PAD patients underwent a CT of the lower extremities. This resulted in 118 CLI patients (mean age 72±12, 70.3% male) that were age-matched with 118 non-PAD patients (mean age 71±11, 51.7% male). The characteristics severity, annularity, thickness and continuity were assessed in the femoral and crural arteries and analysed by binary multiple logistic regression. Results Nearly all CLI patients have calcifications and these are equally frequent in the femoropopliteal (98.3%) and crural arteries (97.5%), while the non-PAD patients had in just 67% any calcifications with more calcifications in the femoropopliteal (70.3%) than in the crural arteries (55.9%, p<0.005). The crural arteries of the CLI patients had significantly more complete annular calcifications (OR 2.92, p=0.001.) while in the non-PAD patients dot-like calcifications dominated. In CLI patients, the femoropopliteal arteries had more severe, irregular / patchy and thick calcifications (OR 2.40, 3.27, 1.81, p≤0.05, respectively) while in non-PAD patients, thin continuous calcifications prevailed. Conclusions Compared with non-PAD patients CLI patients are more frequently and extensively calcified. Annular calcifications were found in the crural arteries of CLI patients while dot-like calcifications were mostly present in the non-PAD patients. These different patterns of calcifications in CLI point at different etiology and can have prognostic and eventually therapeutic consequences.

Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0143.v1

Income Levels and Mortality Rates in Patients with Chronic Kidney Disease in South Korea: a Population-Based Cohort Study Using National Health Insurance Data

Young Choi

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic kidney disease; low socioeconomic status; mortality

Online: 6 August 2020 (09:46:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0342.v1

Factors Associated With Chronic Kidney Disease in Patients With Type 2 Diabetes in Bangladesh

Sheikh Mohammed Shariful Islam, Masudus Salehin, Sojib Bin Zaman, Tania Tansi, Rajat Das Gupta, Lingkan Barua, Palash C Banik, Riaz Uddin

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 2 Diabetes Mellitus; Chronic Kidney Diseases; Hypertension; Risk Factors; Bangladesh

Online: 19 November 2021 (09:26:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1329.v1

A Review about Lateral Ankle Instability and Emerging Alternative Outcome Monitoring Tools in Patients Following Ankle Ligament Reconstruction Surgery

Ibrahim Saliba, Alexandre Hardy, Wenzheng Wang, Raphael Vialle, Sylvain Feruglio

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: ankle instability; chronic ankle instability; postoperative management; diagnostics; NIRS

Online: 18 December 2023 (12:45:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1898.v1

First-line Treatment of the Older Patients with CLL: A New Approach in the Chemo-free Era

Antonio Urso, Francesco Cavazzini, Maria Pia Ballardini, Silvia Gambara, Sara Consolo, Gian Matteo Rigolin, Antonio Cuneo

Subject: Medicine And Pharmacology, Hematology Keywords: chronic lymphocytic leukemia; older patient; ibrutinib; acalabrutinib; zanubrutinib; venetoclax; sustainabiity

Online: 27 June 2023 (12:04:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1193.v1

The Influence of Emotional Intelligence in Quality of Life in Patients Undergoing Chronic Hemodialysis

Afra Masià-Plana, Miquel Sitjar-Suñer, Susana Mantas-Jiménez, Rosa Suñer-Soler

Subject: Public Health And Healthcare, Nursing Keywords: Chronic Kidney Disease; Hemodialysis; Emotional Intelligence; Quality of life; Sex differences; Nursing

Online: 16 January 2024 (06:22:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1348.v1

Examining the Impact of Infection Reactivation on Extracellular Vesicles purified from Patients with Chronic Chagas Disease

Rafael Pedro Madeira, Paula Meneghetti, Nicholy Lozano, Gislene M. Namiyama, Vera Lucia Pereira-Chioccola, Ana Claudia Torrecilhas

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; extracellular vesicles; chronic Chagas Disease patients; immunosuppression; infection reactivation.

Online: 18 December 2023 (15:17:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0339.v1

Comparative Analysis of Vascular Calcification Risk Factors and Biomarkers in Pre-Hemodialysis and Prevalent Hemodialysis Patients

Marko Petrović, Voin Brković, Marko Baralić, Ivko Maric, Nenad Petković, Sanja Stankovic, Natasa Lalic, Dejana Stanisavljevic, Višnja Ležaić

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease patients 1; vascular calcifications 2; risk factors 3

Online: 7 November 2023 (02:49:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0043.v3

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients

Daniel Missailidis, Sarah Annesley, Claire Allan, Oana Sanislav, Brett Lidbury, Donald Lewis, Paul Fisher

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Myalgic Encephalomyelitis; Chronic Fatigue Syndrome; mitochondria; Complex V; TORC1; Seahorse respirometry

Online: 3 February 2020 (09:34:29 CET)

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Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic condition characterized by exacerbation of symptoms after exertion (post-exertional malaise or “PEM”), and by fatigue whose severity and associated requirement for rest are excessive and disproportionate to the fatigue-inducing activity. There is no definitive molecular marker or known underlying pathological mechanism for the condition. Increasing evidence for aberrant energy metabolism suggests a role for mitochondrial dysfunction in ME/CFS. Our objective was therefore to measure mitochondrial function and cellular stress sensing in actively metabolising patient blood cells. We immortalized lymphoblasts isolated from 51 ME/CFS patients diagnosed according to the Canadian Consensus Criteria and an age- and gender-matched control group. Parameters of mitochondrial function and energy stress sensing were assessed by Seahorse extracellular flux analysis, proteomics, and an array of additional biochemical assays. As a proportion of the basal oxygen consumption rate (OCR), the rate of ATP synthesis by Complex V was significantly reduced in ME/CFS lymphoblasts, while significant elevations were observed in Complex I OCR, maximum OCR, spare respiratory capacity, nonmitochondrial OCR and “proton leak” as a proportion of the basal OCR. This was accompanied by a reduction of mitochondrial membrane potential, chronically hyperactivated TOR Complex I stress signalling and upregulated expression of mitochondrial respiratory complexes, fatty acid transporters and enzymes of the β-oxidation and TCA cycles. By contrast, mitochondrial mass and genome copy number, as well as glycolytic rates and steady state ATP levels were unchanged. Our results suggest a model in which ME/CFS lymphoblasts have a Complex V defect accompanied by compensatory upregulation of their respiratory capacity that includes the mitochondrial respiratory complexes, membrane transporters and enzymes involved in fatty acid β-oxidation. This homeostatically returns ATP synthesis and steady state levels to “normal” in the resting cells, but may leave them unable to adequately respond to acute increases in energy demand as the relevant homeostatic pathways are already activated.

Preprint ARTICLE | doi:10.20944/preprints202306.2098.v1

Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Dialysis in Vietnam

Tan Van Nguyen, Thu Thi Xuan Pham, Mason Jenner Burns, Tu Ngoc Nguyen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic kidney disease; end-stage renal disease; dialysis; diabetes; frailty; elderly; Vietnam

Online: 29 June 2023 (10:16:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0101.v1

Developing and Validating an Algorithm to Identify Incident Chronic Dialysis Patients Using Administrative Data

Dino Gibertoni, Claudio Voci, Marica Iommi, Benedetta D'Ercole, Marcora Mandreoli, Antonio Santoro, Elena Mancini

Subject: Computer Science And Mathematics, Information Systems Keywords: chronic dialysis; administrative data; hospital discharge records; ambulatory specialty visits; case definition; algorithm

Online: 6 May 2020 (15:26:06 CEST)

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Background: Administrative healthcare databases are widespread and are often standardized with regard to their content and data coding, thus they can be used also as data sources for surveillance and epidemiological research. Chronic dialysis requires patients to frequently access hospital and clinic services, causing a heavy burden to healthcare providers. This also means that these patients are routinely tracked on administrative databases, yet very few case definitions for their identification are currently available. The aim of this study was to develop two algorithms derived from administrative data for identifying incident chronic dialysis patients and test their validity compared to the reference standard of the regional dialysis registry. Methods: The algorithms are based on data retrieved from hospital discharge records (HDR) and ambulatory specialty visits (ASV) to identify incident chronic dialysis patients in an Italian region. Subjects are included if they have at least one event in the HDR or ASV databases based on the ICD9-CM dialysis-related diagnosis or procedure codes in the study period. Exclusion criteria comprise non-residents, prevalent cases, or patients undergoing temporary dialysis, and are evaluated only on ASV data by the first algorithm, on both ASV and HDR data by the second algorithm. We validated the algorithms against the Emilia-Romagna regional dialysis registry by searching for incident patients in 2014. Results: Algorithm 1 identified 680 patients and algorithm 2 identified 676 initiating dialysis in 2014, compared to 625 patients included in the regional dialysis registry. Sensitivity for the two algorithms was respectively 90.8% and 88.4%, positive predictive value 84.0% and 82.0%, and percentage agreement was 77.4% and 74.1%. Conclusions: These results suggest that administrative data have high sensitivity and positive predictive value for the identification of incident chronic dialysis patients. Algorithm 1, which showed the higher accuracy and has a simpler case definition, can be used in place of regional dialysis registries when they are not present or sufficiently developed in a region, or to improve the accuracy and timeliness of existing registries.

Preprint ARTICLE | doi:10.20944/preprints201811.0185.v1

The Use of Dietary Interventions in Pediatric Patients

Shirin Madzhidova, Lusine Sedrakyan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: pediatric pharmacy; complementary alternative medicine; dietary interventions; oral manifestations; chronic pediatric conditions; ketogenic diet; gluten free casein free diet

Online: 8 November 2018 (03:55:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0217.v1

Factors Associated with the Prevalence of Malnutrition among Adult Haemodialytic Patients: A Two-Centre Study in Jeddah Region, Saudi Arabia

Firas S. Azzeh, Waad M. Turkistani, Mazen M. Ghaith, Lujain A. Bahubaish, Osama A. Kensara, Hussain A. Almasmoum, Abdullah F. Aldairi, Anmar A. Khan, Ahmad A. Alghamdi, Ghalia Shamlan, Maha H. Alhussain, Reham M. Algheshairy, Abdullah M. AlShahrani, Maysoun S. Qutob, Awfa Y. Alazzeh, Haitham M. Qutob

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Chronic Kidney Disease; Protein-Energy Wasting; Modified-Subjective Global Assessment

Online: 25 April 2022 (04:53:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0595.v1

Safety and Efficacy of TKIs in Very Elderly Patients (≥75 Years) with Chronic Myeloid Leukemia

Alessandro Costa, Elisabetta Abruzzese, Roberto Latagliata, Olga Mulas, Ida Carmosino, Emilia Scalzulli, Maria Laura Bisegna, Claudia Ielo, Maurizio Martelli, Giovanni Caocci, Massimo Breccia

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; tyrosine kinase inhibitor; very elderly; safety; efficacy; outcome; dose optimization

Online: 8 December 2023 (10:26:16 CET)

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Background: While outcomes of chronic phase chronic myeloid leukemia (CP-CML) patients aged over 65 years have been extensively evaluated in real-life experiences, limited data exist for the very elderly population (i.e., aged ≥ 75 years), especially for next-generation tyrosine kinase inhibitors (TKIs). In this retrospective study, we sought to evaluate the safety and efficacy of TKIs in this particular setting of patients. Methods: We conducted a retrospective analysis of a multicenter cohort of 123 newly diagnosed CP-CML very elderly patients. Results: The median age at diagnosis was 80 years (range: 75-96). In the first-line, 86.1% of patients received imatinib, 7.1% dasatinib, 5.6% nilotinib, and 0.81% received bosutinib. A total of 31 patients (25.2%) switched to second-line therapy, nine patients to a third-line and one patient to a fourth line of therapy. Resistance to treatment was the primary reason for switching therapy in both the first (64.5%) and second lines (77.7%). At diagnosis, reduced doses were administered in 36.5% of patients, in 61.2% in the second line, and in all patients in subsequent lines of therapy. In first-line setting, 71.9% of patients achieved an early molecular response (EMR, i.e. 3-month BCR::ABL1 IS <10%); at 6, 12, and 24 months, MR3 was reached by 35.7%, 55.7%, and 75.0% of patients, with 16.6%, 35.7%, and 51.7% achieving DMR at the same timepoints. Treatment-free remission (TFR) was successfully attempted in 11 patients. During the follow-up period, adverse events (AEs) were observed in 78.8% of patients, including 22 cases of cardiovascular AEs. Toxicity grade ≥ 3 was more commonly observed in patients treated with standard doses of TKIs compared to reduced doses (p=0.033). Overall, median follow-up was 46.62 months (range: 1.8-206.2), and 43 patients died due to non CML related causes. Three patients died due to disease progression to advanced (n=1) and blastic (n=2) phases. The 5-year overall survival (OS) for the entire cohort was 71.9% (95% CI: 0.63-0.81), with no significant difference between patients treated with standard doses of TKI compared to those treated with reduced doses (p=0.35). Conclusions: TKIs appear to be safe and effective even in very elderly CML patients, and dose optimization strategies yield satisfactory molecular responses for adequate disease control with an improved safety profile.

Preprint ARTICLE | doi:10.20944/preprints202104.0173.v1

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-based Study

Joaquim Oristrell, Joan C. Oliva, Isaac Subirana, Enrique Casado, Didier Dominguez, Andrea Toloba, Patricia Aguilera, Joan Esplugues, Pilar Fafian, Maria Grau

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: calcitriol; vitamin D; COVID-19; SARS-CoV2 infection; chronic kidney disease

Online: 6 April 2021 (11:50:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0569.v1

Effects of Clinical Characteristics on Sleep Quality in Patients with Chronic Temporomandibular Disorders

Yeon-Hee Lee, Q-Schick Auh, Jung-Sub An, Tae Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sleep quality; Chronic pain; Temporomandibular disorder; Pittsburgh Sleep Quality Index; STOP-Bang; Epworth Sleepiness Scale

Online: 23 June 2021 (11:11:14 CEST)

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Objectives: This study aimed to investigate and compare sleep quality between patients with chronic temporomandibular disorder and healthy controls, and to analyze the association of sleep quality with disease characteristics, obstructive sleep apnea risk factors, and excessive daytime sleepiness. Methods: Chronic temporomandibular disorder patients (n=503) and 180 age- and sex-matched healthy controls were included, who completed well-organized clinical report and answered questions on sleep quality (Pittsburgh Sleep Quality Index), sleep apnea risk factors (STOP-Bang questionnaire), and excessive daytime sleepiness (Epworth sleepiness scale). Results: Mean global Pittsburgh Sleep Quality Index scores were significantly higher in the patients (6.25±2.77) than in healthy controls (6.25±2.77) (p<0.001). Poor sleep was significantly more prevalent in the patient group (56.9%) than in healthy controls (22.2%) (p<0.001). Compared with healthy controls, chronic temporomandibular disorder patients had a higher likelihood of obstructive sleep apnea. (STOP-Bang total score ≥3; 7.2% vs. 16.1%; p<0.01) and higher excessive daytime sleepiness (Epworth sleepiness scale score ≥10; 12.8% vs. 19.7%; p<0.05). Age (odds ratio=2.551; p<0.001), female sex (odds ratio=1.885; p=0.007), total Epworth sleepiness scale score (odds ratio=1.839; p=0.014), and headache attributed to temporomandibular disorder (odds ratio=1.519; p=0.049) were the most powerful predictors of poor sleep (global Pittsburgh Sleep Quality Index score ≥5) in chronic temporomandibular disorder patients. Conclusion: Chronic temporomandibular disorder patients had sleep quality impairment. Various factors, including peripheral and central factors, affect the patient's sleep quality. Therefore, in addition to sleep quality and sleep-related problems, the underlying central mechanism for poor sleep quality should be assessed when treating chronic temporomandibular disorder patients.

Preprint ARTICLE | doi:10.20944/preprints201810.0254.v1

Solanum Fruit Juice as a Natural and Sustainable Source of Antioxidants for Patients with Chronic Hepatitis C under Antiviral Therapy

Chidiebere Uchenna Iheka, Justice Obinna Osuoha, Idongesit Ekong Archibong, Peter Uchenna Amadi, Oluwatoyin Taiwo Adeoti

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Solanum fruit juice; biochemical markers; chronic hepatitis C; oxidative stress; antioxidants

Online: 12 October 2018 (04:55:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1870.v1

Polish Adaptation and Psychometric Validation of the PREM-C9 Questionnaire Dedicated for Patients with Chronic Obstructive Pulmonary Disease

Iwona Damps-Konstańska, Weronika Ciećko, Ewa Jassem, Tomasz Bandurski, Dominika Bosek, Marzena Olszewska-Karaban, Ewa Bandurska

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic obstructive pulmonary disease (COPD); Patient Reported Outcome Measures; Health Care Surveys

Online: 29 August 2023 (03:31:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0213.v1

High Sensitivity Cardiac Troponin T in Patients with Severe Chronic Kidney Disease and suspected Acute Coronary Syndrome

Brunilda Alushi, Fabian Jost-Brinkmann, Adnan Kastrati, Salvatore Cassese, Massimiliano Fusaro, Karl Stangl, Ulf Landmesser, Holger Thiele, Alexander Lauten

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: troponin; high-sensitivity; chronic kidney disease; renal insufficiency; myocardial infarction; acute coronary syndrome

Online: 10 August 2021 (08:45:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2135.v1

Vaccination against Influenza: Clinical and Cytokine Profile of Patients with Asthma and Chronic Obstructive Pulmonary Disease

Мikhail Petrovich Kostinov, Alexander Chuchalin, Anna Chebykina, Nelli Kimovna Akhmatova, Valentina Borisovna Polishchuk, Nadezhda Kryukova, Aristitsa M. Kostinova, Anna E Vlasenko, Alexander Petrovich Cherdantsev, Irina Leonidovna Solovieva, Marina Loktionova, Anna Dmitrievna Shmitko, Lilya Solomonovna Gladkova, Yvette Albahansa Mana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Influenza vaccine; Grippol® Plus; asthma; chronic obstructive pulmonary disease; vaccine efficacy; cytokines; CRP

Online: 30 September 2023 (08:27:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0018.v2

Effects of Excitatory Repetitive Transcranial Magnetic Stimulation of the P3 Point in Chronic Stroke Patients – Case Reports

Ronaldo Luis da Silva, Angela Maria Costa de Souza, Francielly Ferreira Santos, Sueli Toshie Inoue, Johanne Higgins , Victor Frak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: intraparietal sulcus; stroke; rTMS; Fugl-Meyer Assessment; fast frequency TMS; motricity; sensibility; chronic patients

Online: 17 April 2018 (08:35:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0311.v1

Retrospective Cross-Sectional Study on Chronic Hepatitis C in Estonia, Latvia, Lithuania, and Ukraine: Virus, Patient, and Disease Characteristics in Patients under Care (RESPOND-C Study)

Ligita Jančorienė, Baiba Rozentāle, Ieva Tolmane, Agita Jēruma, Riina Salupere, Arida Buivydienė, Jonas Valantinas, Limas Kupčinskas, Jolanta Šumskienė, Eglė Čiupkevičienė, Arvydas Ambrozaitis, Olga Golubovska, Larysa Moroz, Robert Flisiak, Borys Bondar

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Baltic states; chronic hepatitis C; epidemiology; hepatitis C virus; genotype; Ukraine

Online: 5 July 2023 (12:30:04 CEST)

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Background and objectives: Since 2013, highly effective direct-acting (DAA) chronic hepatitis C (CHC) antiviral therapy became available, which has cure rates of over 95%. For choice of optimal CHC treatment, assessment of hepatitis C virus (HCV) genotype (GT) and liver fibrosis stage are necessary. Information about distribution of these parameters among CHC patients in Baltic states and especially in Ukraine is scarce. This study was performed to obtain epidemiological data regarding CHC GT and fibrosis stage distribution for better planning of resources and prioritization of patients for DAA drug treatment according to disease severity in high-income (Baltic states) and lower-middle income (Ukraine) countries. Materials and Methods: This was an epidemiological, retrospective, cross-sectional study that included 1451 CHC patients. Demographic and disease information from medical charts was collected for each patient during a single visit. Results: Most frequent suspected mode of viral transmission was blood transfusions (17.8%), followed by injection drug use (15.7%); however, in 50.9% of patients exact mode of transmission was not clarified. In Ukraine (18.4%) and Estonia (26%) transmission by the injection drug use was higher than in Lithuania (5%) and Latvia (5.3%). Distribution of HCV GT among patients with CHC was as follows: GT1 - 66.4%; GT3 - 28.1; and GT2 - 4.1%. The prevalence of GT1 was the highest in Latvia (84%), and the lowest in Ukraine (63%, p<0.001). Liver fibrosis stages were distributed as follows: F0 - 12.2%, F1 - 26.3%, F2 - 23.5%, F3 – 17.1% and F4 - 20.9%. Cirrhosis (F4) was more prevalent in Lithuanian patients (30.1%) than in Estonians (8.1%, p <0.001). Conclusions: This study contributes to the knowledge of epidemiological characteristics of HCV infection in the Baltic states and Ukraine. The data regarding the patterns of HCV GT and fibrosis stage distribution will be helpful for the development of national strategies to control HCV infection in the era of DAA therapy.

Preprint ARTICLE | doi:10.20944/preprints202209.0178.v1

A Prospective Cohort Study: Erector Spinae Plane Block Decreases Chronic Postoperative Pain Severity in Patients Undergoing Coronary Artery Bypass Grafting

Marcin Wiech, Sławomir Żurek, Arkadiusz Kurowicki, Beata Horeczy, Mirosław Czczuwar, Paweł Piwowarczyk, Kazimierz Widenka, Michał Borys

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic postoperative pain; erector spinae plane block; coronary artery bypass grafting; Neuropathic Pain Symptom Inventory

Online: 13 September 2022 (11:24:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0045.v1

Effects of Direct-Acting Antiviral Agents on the Mental Health of Patients with Chronic Hepatitis C: A Prospective Observational Study

Michele Fabrazzo, Rosa Zampino, Martina Vitrone, Gaia Sampogna, Lucia Del Gaudio, Daniela Nunziata, Salvatore Agnese, Anna Santagata, Emanuele Durante-Mangoni, Andrea Fiorillo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic hepatitis C; Direct-acting antiviral agents; Hepatitis C virus; Consultation-liaison psychiatry; Depression; Anxiety

Online: 5 July 2020 (05:15:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0488.v1

Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C

Valeriy Tsvetkov, Ivan Tokin, Dmitriy Lioznov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hepatitis C virus; Chronic viral hepatitis C; Liver fibrosis; Liver cirrhosis; Diagnosis of liver fibrosis; Machine learning

Online: 22 February 2021 (15:31:11 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.1407.v1

B Cell Subsets and Immune Checkpoint Expression in Patients With Chronic Lymphocytic Leukaemia

Aviwe Ntsethe, Zekhethelo Alondwe Mkhwanazi, Phiwayinkosi Vusi Dludla, Bongani Brian Nkambule

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic lymphocytic leukaemia; immune checkpoints; B cell subsets; beta-2 microglobulin; programmed death protein 1; cytotoxic T-lymphocyte associated protein 4

Online: 19 January 2024 (04:36:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1523.v1

Topical Application of Autologous Leukocyte-Rich Platelet-Rich Plasma with a High Concentration of Monocytes in Patients with Recalcitrant Ischemic Diabetic Foot Ulcers: Efficacy, Safety and Economic Evaluation.

Benedetta Ragghianti, Giovanni Antonio Silverii, Bianca Maria Berardi, Linda Luppichini, Maria Masulli, Matteo Monami

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; Foot ulcer; Cell-therapy; Chronic Limb-Threatening Ischemia; Economic evaluation

Online: 20 December 2023 (10:18:08 CET)

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BACKGROUND: Patients with diabetic foot ulcers (DFU) and chronic limb-threatening ischemia (CLTI are at higher risk for major amputations and mortality. The aim of this study was to assess the safety and cost-efficacy of intramuscular injection of autologous monocyte-rich PRP platelet-rich plasma Tropocells® PRP (Estar Medical, Holon, Israel) in diabetic patients with chronic limb-threatening ischemia (CLTI) in which revascularization was not feasible. METHODS: a retrospective study was carried out on a series of patients with type 2 diabetes, grade Texas 3C or D DFU, and CLTI. All patients had undergone at least a previous revascularization and were allocated to a surgery waiting list for major amputation. According to the data provided by the manufacturer (https://www.zuccatobiotech.it/index.php/prodotti/tropocells), the monocyte-rich PRP kit obtained a platelet-rich plasma with a high concentration of peripheral blood mononuclear cells (with a proportionately lower amount of lymphocytes), a low concentration of neutrophils and an almost complete depletion of red blood cells. All patients underwent a procedure of local infiltration of autologous mononuclear cells through multiple perilesional and intramuscular injections of 10 mL PBMNC suspensions (0.2–0.3 mL in boluses) performed below the knee along the relevant vascular axis (anterior tibial artery and posterior tibial artery) at intervals of 1–2 cm and to a mean depth of 1.5–2 cm, using a 21 G needle. The procedures were performed according to the instructions of the manufacturer and were repeated at least two times (maximum 3 times) at intervals of 30 days. The principal endpoint was a composite of TcPO2 values at the first toe ≥30 mmHg and/or TcPO2 increase of at least 50% from baseline and/or ulcer healing. Secondary endpoints were individual components of the primary endpoint, quality of life, any adverse events, and direct costs. All the endpoints were evaluated at 26 weeks. RESULTS: Out of 21 enrolled patients, 13 (61.9%) reached the primary endpoint, whereas three patients underwent a major amputation, and two patients died. The median TpCO2 was significantly increased, and pain was significantly reduced. The overall mean and median cost per patient were 9,255±7,328€ and 4,001 [2,991;7,565]€, respectively. CONCLUSIONS: the use of PBMNCs implants in patients with DFU and no-option CLTI seems to be efficacious in reducing the risk of major amputation and improve ulcer healing.

Preprint ARTICLE | doi:10.20944/preprints202312.1499.v1

Next-Generation DNA Sequencing Identifies Mutated FANCD2 Gene as a Novel Biomarker for Monitoring Early Disease Progression and Timely Therapeutic Interventions in Advanced Phase Chronic Myeloid Leukemia Patients

Nawaf Alanzazi, Abdulaziz Siyal, Muhammad Absar, Masood Shammas, Sarah Almukhaylid, Amer Mahmood, Zafar Iqbal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Chronic Myeloid Leukemia; CML progression; Poor survival; genomic instability; DNA repair; FANCD2

Online: 20 December 2023 (04:54:34 CET)

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Chronic Myeloid Leukemia, resulting due to chromosomal aberration t(9;22) through formation of oncogenic BCR-ABL fusion oncogene. Modern BCR-ABL inhibitors, called TKIs, have revolutionized CML treatment. CML has three stages: chronic, accelerated, and blast crisis. TKIs work well in CP-CML, where patients survive as long as the normal population, but they don't work in AP- and BC-CML. Even with advances in treatment, BC-CML has an average overall survival of less than a year, giving oncologists little time to clinically intervene. Oncologists can delay or prevent CML advancement by detecting patients at risk of disease progression early and making timely treatment decisions, especially with third and fourth generation TKIs. However, no universal molecular biomarkers exist to diagnose CML patient groups at risk of disease progression. A recent study found that all BC-CML patients have mutant FANCD2. Our study was designed to detect mutant FANCD2 in AP-CML (early progression phase) to investigate its potential as a novel biomarker of early CML progression from chronic phase to accelerated phase due to the urgent need for such a biomarker. Our study comprised of 123 CP-CML (control group) and 60 AP-CML patients (as experimental group) from Hayatabad Medical Complex, Peshawar, Pakistan, from Jan 2020 to July 2023. DNA was extracted from the patients and FANCD2 gene was sequenced using Illumina next generation sequencer (NGS) Illumina MiSeq sequencer. NGS analysis revealed a unique splice site mutation in FANCD2 gene (c. 2022-5C>T). This mutation was detected in all CP-CML patients but in none of CP-CML. The mutation was confirmed by Sanger sequencing. FANCD2 is member of Fanconi anemia (FA-) pathway gene involved in DNA repair and genomic instability. Therefore, our studies show that FANCD2 (c. 2022-5C>T) mutation as a very specific molecular biomarker for early CML progression. We recommend to clinical validate this biomarker is prospective clinical trials.

Preprint ARTICLE | doi:10.20944/preprints201912.0358.v1

Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients

Tamara Ovejero, Océane Sadones, Teresa Sánchez-Fito, Eloy Almenar-Pérez, José Andrés Espejo, Eva Martín-Martínez, Lubov Nathanson, Elisa Oltra

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: fibromyalgia; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); HERV (Human Endogenous Retrovirus); transposable elements; epigenetics; DNA methylation; tsRNAs (transfer RNA small fragments); interferon; non-Hodgkin's lymphoma

Online: 27 December 2019 (03:30:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1854.v1

Investigation of Renal Function in Patients with Long COVID in the Amazon Region: A Cross-Sectional Study

Gabriela Maria Coimbra Coelho de Assis, Ian Gonçalves da Veiga, Rita de Nazaré Rayol Reis, Daniel Carvalho de Menezes, Stanley Soares Xavier, Jorge Rodrigues de Sousa, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão, Patrícia Danielle Lima de Lima

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: SARS-CoV-2; COVID -19; Chronic Kidney Disease; Long COVID; Acute Kidney Injury; Amazon region; Kidney function tests

Online: 27 June 2023 (07:20:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.0421.v1

Enhancing Post-Surgical Rehabilitation Outcomes in Patients with Chronic Ankle Instability: Impact of Subtalar Joint Axis Balance Exercises Following Arthroscopic Modified Broström Operation

Ji Myeong Park, Sang Ho Han, Byeong Chae Cho, Se Min Lee, Mal Soon Shin, Jae Ho Yu, Ho Jin Kim, Hyun Dong Noh, Min Suk Cho, Myung Ki Kim

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Anterior talofibular ligament; arthroscopic modified Broström operation; chronic ankle instability; subtalar joint axis balance exercises

Online: 4 January 2024 (14:30:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1171.v1

Topical Application of Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers: Efficacy, Safety and Economic Evaluation

Benedetta Ragghianti, Bianca Maria Berardi, Edoardo Mannucci, Matteo Monami

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; Foot ulcer; Cell-therapy; Small Artery Disease; Chronic Limb-Threatening Ischemia; Economic evaluation

Online: 17 May 2023 (02:41:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1998.v1

Low Post-treatment Quality of Life and the High Incidence of Pain are Common and Significantly Exacerbated in Depressed Head and Neck Patients Treated with Definitive Accelerated Radiotherapy

Alicja Heyda, Dorota Księżniak-Baran, Andrzej Wygoda, Krzysztof Składowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: definitive accelerated radiotherapy; depression; chronic pain; head and neck cancer; quality of life

Online: 28 September 2023 (10:41:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0917.v1

Comparative Analysis of Vascular Calcification Risk Factors in Pre-hemodialysis and Prevalent Hemodialysis Adult Patients: Insights into Calcification Biomarker Associations and Implications for Intervention Strategies in Chronic Kidney Disease

Marko Petrović, Voin Brković, Marko Baralić, Ivko Marić, Nenad Petković, Sanja Stanković, Nataša Lalić, Danijela Stanisavljević, Ljubica Đukanović, Višnja Ležaić

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; vascular calcifications; FGF-23; Fetuin-A; sclerostin; iPTH; Adragao score

Online: 17 February 2024 (09:04:37 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0188.v1

How Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) Progresses: A Framework for Research and the Prevention, Treatment, and Rehabilitation in ME/CFS

Luis Nacul, Shennae O'Boyle, Flavio E. Nacul, Kathleen Mudie, Caroline C. Kingdon, Jacqueline M. Cliff, Taane G. Clark, Hazel M. Dockrell, Eliana M. Lacerda

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Chronic Fatigue Syndrome; Chronic Illness; ME/CFS; Management; Research

Online: 17 September 2019 (12:38:57 CEST)

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We propose a framework for the understanding of the pathophysiology and management of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) that considers wider determinants of health and long-term temporal variation in pathophysiological features and disease phenotype throughout the natural history of the disease. As in other chronic diseases, ME/CFS evolves through different stages, from asymptomatic predisposition, progressing to a prodromal stage, and then to symptomatic disease. Disease incidence depends on genetic makeup and environment factors, the exposure to an insult, or repeated insults, and the nature of the host response. In people who develop ME/CFS, normal homeostatic processes in response to adverse insults may be replaced by aberrant responses leading to dysfunctional states. Thus, the predominantly neuro-immune and autonomic manifestations, underlined by a hyper-metabolic state, that characterise early disease, may be followed by various processes leading to multi-systemic related symptoms. This abnormal metabolic state and the effects of a range of mediators such as products of oxidative and nitrosamine stress, may lead to progressive cell and metabolic dysfunction culminating in a hypometabolic state with low energy production. These processes do not seem to happen uniformly; although a spiralling of progressive inter-related and self-sustaining abnormalities may ensue, reversion to states of milder abnormalities is possible if the host is able to restate responses to improve homeostatic equilibrium. Disease management and research efforts should seek to identify and apply strategies targeted at the different pathophysiological dysfunctions that characterise different disease stages. As disease presentation varies over time, no single case description, set of diagnostic criteria, or molecular feature is currently diagnostic for all patients at all times. While acknowledging its limitations due to the incomplete research evidence, we suggest the proposed framework may improve research design and health care interventions for people with ME/CFS.

Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0095.v1

Improving Quality of Life in Chronic Patients: A Pilot Study on the Effectiveness of a Health Recommender System and Its Usability

Alberto del Rio, Jennifer Jimenez, Rodrigo Medina-García, Cristina Lozano-Hernández, Federico Alvarez, Javier Serrano

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: health recommender system; recommender system; sensorial ecosystem; continuous monitoring; chronic diseases; integrated care; quality of life; elderly care

Online: 6 April 2023 (12:23:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1566.v1

Modulation of miR-29a and miR-29b Expression by an Oral Nutritional Supplement Similar to the Mediterranean Diet Pattern with Probiotics in Malnourished Hemodialysis Patients

Corina Verónica Sasso, Said Lhamyani, Francisco Hevilla, Marina Padial, María Blanca, Guillermina Barril, Tamara Jiménez-Salcedo, Enrique Sanz Martínez, Ángel Nogueira, Ana María Lago-Sampedro, Gabriel Olveira

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic kidney disease; oral nutritional supplement; malnutrition; hemodialysis; probiotics; circulating miRNAs; gene expression; inflammation; renal fibrosis

Online: 20 December 2023 (13:46:40 CET)

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Malnutrition is prevalent in patients with chronic kidney disease (CKD), especially those on hemodialysis. Recently, our group described that a new oral nutritional supplement (ONS) for malnourished (or at-risk) hemodialysis patients with a "similar to the Mediterranean diet" model, improved caloric and protein intake, nutritional status and inflammation and oxidation biomarkers. Our aim in this study was to evaluate whether the new ONS, including probiotics, may produce changes in miRNAs expression and its target genes in malnourished hemodialysis patients, compared to individualized diet recommendations. We conducted a randomized, multicenter, parallel-group study in malnourished hemodialysis patients divided in 3 groups (1: Control -C- individualized diet 2: Oral nutritional supplement -ONS- + placebo -ONS-PL- and 3: ONS + probiotics -ONS-PR). Study registration: NCT03924089. The trial was open to the ONS diet or individual dietary advice, but double-blind for the intake of probiotics supplements. MiRNAs and gene expression levels were analyzed by RT-qPCR at baseline and after 3 and 6 months. We observed that the expression of miR-29a and miR-29b increased significantly in patients with ONS-PR at 3 months in comparison with baseline, stabilizing at the sixth month. Moreover, we observed differences between studied groups, where miR-29b expression levels were elevated in patients receiving ONS-PR compared to the control group in the third month. Regarding the gene expression levels, we observed a decrease in the ONS-PR group compared to the control group in the third month for RUNX2 and TNFα. TGFB1 expression was decreased in the ONS-PR group compared to baseline in the third month. PTEN gene expression was significantly elevated in the ONS-PR group at 3-months in comparison with baseline. LEPTIN expression was significantly increased in ONS-PL group at 3-month intervention compared to baseline. The new Oral Nutritional Supplement associated with probiotics; increases the expression levels of miR-29a and miR-29b after 3 months of intervention, modifying the expression of target genes with anti-inflammatory and anti-fibrotic actions. This study highlights the potential benefit of this Oral Nutritional Supplement, especially associated with probiotics, in malnourished patients with chronic renal disease on hemodialysis.

Preprint REVIEW | doi:10.20944/preprints202004.0464.v1

Prognosis of COVID-19 in Patients with Liver and Kidney Diseases: An Early Systematic Review and Meta-Analysis

Tope Oyelade, Jaber Alqahtani, Gabriele Canciani

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: COVID-19; SARS-CoV-19; Hepatitis B and C; Cirrhosis; Chronic Kidney Disease; Alcohol-related Liver Disease; Non-alcoholic Steatohepatitis; Necrosis

Online: 25 April 2020 (16:46:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2129.v1

Refractory Immune Thrombocytopenia or Myelodysplastic Syndrome Presenting with Isolated Thrombocytopenia? A Review of Literature and a Case Report

Riccardo Tomasello, Claudia Cammarata, Marta Mattana, Manuela Giuseppa Ingrascì, Giulio Giordano, Alessandro Lucchesi, Waleed Ghanima, Sergio Mario Siragusa, Mariasanta Napolitano

Subject: Medicine And Pharmacology, Hematology Keywords: Immune thrombocytopenia; chronic ITP; myelodysplastic syndrome; chronic myelomonocytic leukemia; refractory thrombocytopenia

Online: 30 September 2023 (07:14:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1307.v1

The Role of Pistacia lentiscus in the Prevention of Chronic Rhinosinusitis Recurrence

Alberto Macchi, Camilla Czaczkes, Maurizio Bignami, Giulia Monti

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Chronic Rhinosinisitis; Pistacia Lentiscus; Biofilm

Online: 26 March 2024 (03:00:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0059.v1

Olfactory Rehabilitation for Chronic Pain: A Multi-Dimensional Approach Supported by fMRI Insights

Mariaconsiglia Santantonio, Carmela Riso, Simona Gaudino, Alessio Simonetti, Giuseppe Varcasia, Francesco Schimperna, Bruno Sergi, Eugenio De Corso, Marco Rossi, Jacopo Galli, Marco De Spirito, Giuseppe Maulucci, Giulio Cesare Passali

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: olfactory rehabilitation; chronic pain; fMRI

Online: 1 March 2024 (18:18:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0148.v1

Innate and Adaptive Immune Responses in Chronic Hepatitis C Virus and Hepatitis B Virus Infection with High Viral Loads

Yutaka Kishida

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: chronic hepatitis C; chronic hepatitis B; innate immune response; adaptive immune response; cytokine; chemokine

Online: 12 April 2019 (10:59:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1787.v1

Vitamin D deficiency, Chronic kidney disease and Periodontitis

Imaan Ganimusa, Emily Chew, Emily Ming-Chieh Lu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Vitamin D, Chronic kidney disease, periodontitis

Online: 24 January 2024 (16:53:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1270.v1

Role of EUS in Early Chronic Pancreatitis

Jimil Shah, Abhirup Chatterjee, Truptesh H Kothari

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic pancreatitis; alcohol; SPINK1; Abdominal pain

Online: 17 January 2024 (05:55:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0210.v1

Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate

Isabel Pavão Martins, Beatriz Nunes Vicente, João Bajouco Nobre, Mariana Dias da Costa, Filipa Dourado Sotero

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cognitive impact; chronic migraine; migraine burden

Online: 3 January 2024 (09:43:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0808.v1

Flourishing Among Children and Adolescents with Chronic Pain and Emotional, Developmental, or Behavioral Comorbidities

Madeline Foster, Jessica Emick, Nathan M. Griffith

Subject: Social Sciences, Psychology Keywords: chronic pain; mental health; comorbidities; flourishing

Online: 10 August 2023 (07:31:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1789.v1

Chronic Granulomatous Disease (CGD): Pathogens and Management

Angel A. Justiz-Vaillant, Arlene Faye-Ann Williams-Persad, Rodolfo Arozarena-Fundora, Darren Gopaul, Sachin Soodeen, Odalis Asin-Milan, Clovis Palmer, Patrick Eberechi Akpaka

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic granulomatous disease; Microorganisms; Neutrophils; Antimicrobials

Online: 26 July 2023 (10:39:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1557.v1

Chronic Granulomatous Disease (CGD): Pathogens and Management

Angel A. Justiz-Vaillant, Arlene Faye-Ann Williams-Persad, Rodolfo Arozarena-Fundora, Patrick Eberechi Akpaka, Darren Gopaul

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic granulomatous disease; Microorganisms; Neutrophils; Antimicrobials

Online: 21 June 2023 (13:10:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0343.v1

A Theoretical Model Explaining the Development and Maintenance of Clinical Burnout

Niclas Almén

Subject: Social Sciences, Psychology Keywords: Chronic stress; Recovery; Burnout; Exhaustion; Maintenance

Online: 17 February 2021 (07:45:19 CET)

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Preprint REVIEW | doi:10.20944/preprints201905.0177.v1

Incidence and Characteristics of Endophthalmitis after Cataract Surgery in Poland, during 2010-2015

Michal S. Nowak, Andrzej Grzybowski, Katarzyna Michalska-Malecka, Jacek P. Szaflik, Milena Koziol, Wojciech Niemczyk, Iwona Grabska-Liberek

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Cataract surgery, acute endophthalmitis, chronic endophthalmitis

Online: 14 May 2019 (15:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0220.v1

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Miao Long, Qiang-Ming Li, Qing Fang, Li-Hua Pan, Xue-Qiang Zha, Jian-Ping Luo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Laminaria japonica; polysaccharide; chronic renal failure

Online: 22 January 2019 (11:50:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0609.v1

Treatment-Free Remission in Chronic Myeloid Leukaemia: Can We Identify Prognostic Factors?

Hilbeen Hisham Saifullah, Claire Marie Lucas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic myeloid leukaemia; chronic phase; Tyrosine kinase inhibitor; Treatment free remission; deep molecular response; BCR-ABL.

Online: 25 June 2021 (08:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0301.v2

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmed, Meng Tang, Junaid Wazir, Xiaohui Zhou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 24 April 2020 (04:30:56 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1619.v1

A Rare Onset of T Lymphoid Blast Crisis in Chronic Myeloid Leukemia with Two Distinct Blast Populations

Alessandra Mongia, Francesca Romano, Sara Ciullini Mannurita, Benedetta Peruzzi, Sara Bencini, Daniela Parrini, Laura Fasano, Alessandra Fanelli

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; T lymphoid blastic crisis

Online: 27 March 2024 (06:21:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1023.v1

The Potential Role of Stem Cells in Wound Healing: A Systematic Review

Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai

Subject: Medicine And Pharmacology, Dermatology Keywords: stem cells; chronic wound; wound healing; dermatology

Online: 19 February 2024 (08:19:53 CET)

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Introduction: Wound healing is a complex cascade involving the orchestration of inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. These cells achieve tissue repair through an interchange of cytokines and growth factors through a controlled inflammation, angiogenesis, and remodeling process. Disruptions in the wound-healing process by comorbid conditions lead to significant morbidity and mortality. Stem cell therapy has emerged as a new strategy to facilitate the wound healing process. Stem cells harvested from different sources can be used for wound repair and regeneration (endothelial progenitor cells, bone marrow, adipose tissue, dermal and inducible pluripotent stem cells). We aimed to review clinical, translational, and primary literature on stem cell therapies in chronic wounds and summarize practical clinical applications to dermatological care. Materials and Methods: A comprehensive search of Pubmed, Embase, Web of Science, Google Scholar, and Cochrane Library was conducted for studies relating to stem cells and wound healing. Duplicate results were removed using Covidence. Titles and abstracts were screened by two independent researchers (BF and KR), with discrepancies resolved through discussion and mutual agreement. Articles were excluded if they were review-type or commentary-type articles. Results: A total of 22,454 articles were retrieved from the search. Deduplication removed 905, and automation removed an additional 18,363 articles. After an initial screening of titles and abstracts, 170 articles remained. Full-text screening resulted in an additional 126 articles being removed, leaving 44 included studies. Discussion: Stem cells used for wound repair and regeneration include endothelial progenitor stem cells and adult stem cells, in the forms of bone marrow-derived mesenchymal stem cells, adipose tissue stem cells, and inducible pluripotent stem cells. Among these sources, adipose tissue-derived mesenchymal stem cells (AD-MSCs) are ideally used due to the abundant supply of fat tissue, ease of isolation, extensive proliferative capacities ex vivo, and their ability to secrete pro-angiogenic factors. AD-MSCs have been used to enhance wound healing in peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and postsurgical wounds after Mohs micrographic surgery. These cells have been delivered to the tissue topically, with scaffolds, combined with plasma-rich proteins, and through atelocollagen in various human studies. These approaches, when combined with local wound care practices, resulted in decreased pain, shorter wound healing times, and better cosmesis. Conclusions: Stem cell transplantation is a potential therapeutic approach in the wound healing process. Transplanted stem cells do not only differentiate into multiple skin cell types but also provide cytokine and growth factors required for wound healing resulting in increased angiogenesis. Thus, this approach may be regarded as an attractive option for intractable wounds that cause major clinical problems, especially chronic lower leg wounds. It can also be used after Mohs micrographic surgery for defects left to heal by secondary intention. Stem cell application may reduce the overall cost burden on the healthcare system and improve the quality of life for patients.

Preprint REVIEW | doi:10.20944/preprints202401.1632.v1

The Efficacy of a Novel Compound from Bovine Milk Colostrum Exosomes and Its Growth Factors in Enhancing the Process of Wound Healing

Mojgan Najafzadeh, Shohreh Jafarinejad, Adi Baumgartner, Jacobo Elies Gomez

Subject: Medicine And Pharmacology, Dermatology Keywords: Bovine Colostrum; Wound healing; Repair; Chronic wound

Online: 23 January 2024 (07:27:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0959.v1

Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Sarah Al Sharie, Scott J. Varga, Lou’i Al-Husinat, Piercarlo Sarzi-Puttini, Mohammad Araydah, Batool Riyad Bal’awi, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Fibromyalgia, Chronic pain, Diagnosis, Management, Emerging treatments.

Online: 12 January 2024 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2155.v1

Effects of Beraprost with or without NOS Inhibitor on Aldosterone and Hemodynamics in Healthy Cats

Takumi Matsuura, Aritada Yoshimura, Ryuji Fukushima

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: beraprost; feline; chronic kidney disease; aldosterone; NOS

Online: 30 September 2023 (05:18:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0559.v1

Optimization of RT-QuIC Assay Duration for Screening Chronic Wasting Disease in White-Tailed Deer

Gokhan Yilmaz, Tamara Morrill, Cian Ward, Gordon Mitchell, Andrei Soutyrine, Hanhong Dan, Min Lin, Jiewen Guan

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: RT-QuIC; Chronic Wasting Disease; Diagnostics; Optimization

Online: 7 September 2023 (15:45:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0063.v1

A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management

Ashish Shetty, Gayathri Delanerolle, Heitor Cavalini, Yinshan Qui, Amy Boyd, Yassine Bouchareb, Anish Thillainathan, Seung Kim, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; non-pharmaceutical pain management; interventions

Online: 1 June 2023 (08:13:11 CEST)

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Background: Chronic, non-cancer pain represents a serious public health and economic issue affecting approximately 20% of the global population. Chronic pain can affect many aspects of patient’s lives, including mental health, employment, and relationships. Current medical management is largely focussed on investigating and managing acute pain. Patients and clinicians are now increasingly aware of the potential benefits of combined treatments or complex interventions in alleviating chronic pain. These approaches include both physical interventions, such as exercise or yoga, as well as psychological support including cognitive behavioural therapy (CBT) and talking therapies. Methods: This study used network meta-analyses to explore the prevalence of complex interventions in pain management, and the effects of these interventions on quality of life, using outcome measures including intensity of chronic pain, assessment of functional disability and participant’s psychological state. Results: Psychological interventions were associated with improvements in pain intensity and depression. Exercise and manipulation technique-based treatments provided a statistically significant reduction in pain intensity. This effect was enhanced when exercise and CBT were combined. Mensendieck somatocognitive therapy (MSCT) plus standard gynaecological treatment (STGT) treatments appeared to have a better effect on chronic pain than multimodal exercise plus CBT treatment. Combined MSCT and STGT treatment, and multimodal exercise plus CBT treatments, reduced pain intensity, whilst MSCT+STGT treatments had a slightly better effect than exercise plus CBT treatment.Conclusions: Complex interventions have become more popular with patients as the risks associated with other interventions including surgery and pharmacological management have become better understood. These interventions can have a significant positive effect both on the physical and psychological health of patients. The analysis presented in this study suggests that further work is warranted in this area and that additional studies are required, both in more geographically diverse locations, and with larger cohorts.

Preprint COMMUNICATION | doi:10.20944/preprints202305.1381.v1

Chronic Viral Hepatitis in Children: Socio-Economic Implications in Romania

Irina Dijmărescu, Alexandra Coroleuca, Adrian Dumitru Dijmarescu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic viral hepatitis; socio-economic status; children

Online: 19 May 2023 (05:07:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1093.v1

Microglial Responses to Stress-Induced Depression: Causes and Consequences

Ruqayya Afridi, Kyoungho Suk

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chronic stress; depression; microglia; neuroinflammation; proinflammatory cytokines

Online: 28 April 2023 (03:28:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0319.v1

Recent Advances in Urinary Peptide and Proteomic Biomarkers in Chronic Kidney Disease: A Systematic Review

Lorenzo Catanese, Justyna Siwy, Harald Mischak, Ralph Wendt, Joachim Beige, Harald Rupprecht

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: biomarkers; chronic kidney disease; peptide; proteomic; urine

Online: 13 April 2023 (10:51:02 CEST)

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Background: Biomarker development, improvement, and clinical implementation in the context of kidney disease has been a central focus of biomedical research for decades. To this point, only serum creatinine and urinary albumin excretion are well accepted biomarkers in kidney disease. With their known blind spot in early stages of kidney impairment and diagnostic limitations there is a need for better and more specific biomarkers. With the rise of large-scale analysis of thousands of peptides in serum or urine samples using mass spectrometry techniques hopes for biomarker development were high. Advances in proteomic research have led to the discovery of an increasing amount of potential proteomic biomarkers and identification of candidate biomarkers for clinical implementation in the context of kidney disease management. In this review we focus on urinary peptide and especially peptidomic biomarkers emerging from recent research and underline the role of those with the highest potential for clinical implementation. Methods: The Web of Science database (all databases) was searched on October 17th, 2020, using the search terms “marker*” OR biomarker* AND “renal disease” OR “kidney disease” AND “proteome*” OR “peptid*” AND “urin*”. English, full-text original articles on humans published within the last 5 years were included which were cited at least 5 times per year. Studies based on animal models, renal transplant studies, metabolite studies, studies on miRNA and studies on exosomal vesicles were excluded focusing on urinary peptide biomarkers. Results: The described search led to the identification of 3668 articles and application of inclusion and exclusion criteria as well as abstract and consecutive full-text analysis of 3 independent authors to a final number of 62 studies for this manuscript. The 62 manuscripts encompassed 8 established single peptide biomarkers and several proteomic classifiers including CKD273 and IgAN237. Discussion: This review provides a summary of recent evidence on single peptide urinary biomarkers in CKD while emphasizing the increasing role of proteomic biomarker research with new research on established and new proteomic biomarkers. Lessons learned from the last 5 years in this review might encourage future studies hopefully resulting in routine clinical applicability of new biomarkers.

Preprint ARTICLE | doi:10.20944/preprints202302.0441.v1

Role of the Nephrologist in Non-Kidney Solid Organ Transplant (NKSOT)

Iris Viejo-Boyano, Luis Carlos López-Romero, Luis D'Marco, Ana Checa-Ros, María Peris-Fernández, Enrique Garrigós-Almerich, María Carmen Ramos-Tomás, Ana Peris-Domingo, Julio Hernández-Jaras

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; solid organ transplant; nephrology

Online: 27 February 2023 (04:45:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0168.v1

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

Connie Rojas, Zhandra Entrolezo, Jessica K. Jarett, Guillaume Jospin, Dawn Kingsbury, Alex Martin, Jonathan A. Eisen, Holly H Ganz

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: fecal microbiota transplant; domestic cat; chronic enteropathies

Online: 10 January 2023 (02:15:25 CET)

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There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effectiveness in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 68 domestic cats with chronic digestive issues that underwent FMT treatment using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after treatment, as well as from their stool donors, and healthy animals. We found that according to their owners, 77% of cats were reported to show improvement in their clinical signs (termed ‘Responders’), and 23% were reported to exhibit no change or a worsening of their clinical signs (termed ‘Non-Responders’). Variation in the fecal microbiomes of FMT recipients most strongly correlated with host clinical signs, diet, and IBD diagnosis. The relative abundances of Collinsella, Negativibacillus, Parabacteroides, and Peptoclostridium changed differentially in FMT recipients. Overall, on average 13% of the bacterial amplicon sequence variants (ASVs) were shared between stool donors and FMT recipients (excluding ASVs already present in FMT recipients prior to treatment). The most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, Collinsella and unclassified Lachnospiraceae. Lastly, FMT recipients that had recently taken antibiotics exhibited increases in microbiome similarity to an age-matched healthy reference set compared to other cats. Cats that had diarrhea or diarrhea with vomiting became more similar to healthy cats than did cats exhibiting other clinical signs. Overall, our results suggest that oral capsule FMT treatment was effective in this group of cats and microbiome responses may be modulated by the FMT recipient’s initial presenting clinical signs, prior IBD diagnosis, recent antibiotic use, and their diet.

Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Working Paper ARTICLE

Gut Microbiota as a Source of Uremic Toxins

Vasily A Popkov, Anastasia A Zharikova, Evgenia A Demchenko, Nadezda V Andrianova, Dmitry B Zorov, Egor Y Plotnikov

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: uremia; uremic toxins; microbiome; chronic kidney disease

Online: 14 July 2021 (13:04:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0577.v1

Association of Edentulism With Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey

Alejandro José Casanova-Rosado, Juan Fernando Casanova-Rosado, Mirna Minaya-Sánchez, José Luís Robles-Minaya, Juan Alejandro Casanova-Sarmiento, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Horacio Isla-Granillo, Mariana Mora-Acosta, Sonia Márquez-Rodríguez, Carlo Eduardo Medina-Solís, Gerardo Maupomé

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Oral health; edentulism; chronic diseases; elders; Mexico

Online: 24 March 2021 (11:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0186.v1

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain

Nuria García-Magro, Yasmina B. Martin, Pilar Negredo, Francisco Zafra, Carlos Avendaño

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic pain; allodynia; trigeminocervical complex; glycine transporters

Online: 5 March 2021 (11:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0199.v1

Clinicopathological Variables and Outcome in Chronic Phase Chronic Myeloid Leukemia Associated with BCR-ABL1 Transcript Type and Body Weight

Mohammad Abdulla, Prem Chandra, Susanna El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed Yassin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; BCR-ABL1 transcript; obesity

Online: 7 August 2020 (13:07:53 CEST)

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