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Preprint ARTICLE | doi:10.20944/preprints202306.0940.v1

18 Months Follow-Up of Deep Molecular Response 4.5 (MR4.5) with Nilotinib in Patients with Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia: A Prospective, Multi-Center Study in China

Bingbing Wen, Yuming Zhang, Haiqing Lin, Jin Lou, Chuangqing Tu, Yirong Jiang, Xiaolian Liu, Yan Chen, Huiqing He, Zelin Liu, Xiaoling Xie, Wangxiang Huang, Liping Pang, Xin Du

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: 18 months; deep molecular response; nilotinib; newly diagnosed; chronic-phase chronic myeloid leukemia

Online: 13 June 2023 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1307.v1

The Role of Pistacia lentiscus in the Prevention of Chronic Rhinosinusitis Recurrence

Alberto Macchi, Camilla Czaczkes, Maurizio Bignami, Giulia Monti

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Chronic Rhinosinisitis; Pistacia Lentiscus; Biofilm

Online: 26 March 2024 (03:00:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0059.v1

Olfactory Rehabilitation for Chronic Pain: A Multi-Dimensional Approach Supported by fMRI Insights

Mariaconsiglia Santantonio, Carmela Riso, Simona Gaudino, Alessio Simonetti, Giuseppe Varcasia, Francesco Schimperna, Bruno Sergi, Eugenio De Corso, Marco Rossi, Jacopo Galli, Marco De Spirito, Giuseppe Maulucci, Giulio Cesare Passali

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: olfactory rehabilitation; chronic pain; fMRI

Online: 1 March 2024 (18:18:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0148.v1

Innate and Adaptive Immune Responses in Chronic Hepatitis C Virus and Hepatitis B Virus Infection with High Viral Loads

Yutaka Kishida

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: chronic hepatitis C; chronic hepatitis B; innate immune response; adaptive immune response; cytokine; chemokine

Online: 12 April 2019 (10:59:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0093.v1

Potential Impact of Diet on Treatment Effect from Anti-TNF Drugs in Inflammatory Bowel Disease

Vibeke Andersen, Axel Kornerup Hansen, Berit Lilienthal Heitmann

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: lifestyle factors; chronic inflammatory diseases; treatment result; treatment response; diet; meat intake; dietary pattern; food; mucosa associated bacteria; epithelium-associated bacteria; microbiome; fibre intake; personalized medicine; mucus; sulphate-reducing bacteria; mucin-degrading bacteria; Western style diet; anti-TNF

Online: 15 March 2017 (07:29:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1270.v1

Role of EUS in Early Chronic Pancreatitis

Jimil Shah, Abhirup Chatterjee, Truptesh H Kothari

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic pancreatitis; alcohol; SPINK1; Abdominal pain

Online: 17 January 2024 (05:55:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0210.v1

Improving the Cognitive Impact of Migraine: A Real-World Study on the Ability to Concentrate

Isabel Pavão Martins, Beatriz Nunes Vicente, João Bajouco Nobre, Mariana Dias da Costa, Filipa Dourado Sotero

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cognitive impact; chronic migraine; migraine burden

Online: 3 January 2024 (09:43:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0808.v1

Flourishing Among Children and Adolescents with Chronic Pain and Emotional, Developmental, or Behavioral Comorbidities

Madeline Foster, Jessica Emick, Nathan M. Griffith

Subject: Social Sciences, Psychology Keywords: chronic pain; mental health; comorbidities; flourishing

Online: 10 August 2023 (07:31:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0343.v1

A Theoretical Model Explaining the Development and Maintenance of Clinical Burnout

Niclas Almén

Subject: Social Sciences, Psychology Keywords: Chronic stress; Recovery; Burnout; Exhaustion; Maintenance

Online: 17 February 2021 (07:45:19 CET)

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Preprint REVIEW | doi:10.20944/preprints201905.0177.v1

Incidence and Characteristics of Endophthalmitis after Cataract Surgery in Poland, during 2010-2015

Michal S. Nowak, Andrzej Grzybowski, Katarzyna Michalska-Malecka, Jacek P. Szaflik, Milena Koziol, Wojciech Niemczyk, Iwona Grabska-Liberek

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Cataract surgery, acute endophthalmitis, chronic endophthalmitis

Online: 14 May 2019 (15:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0220.v1

Renoprotective Effect of Laminaria japonica Polysaccharide in Adenine-Induced Chronic Renal Failure

Miao Long, Qiang-Ming Li, Qing Fang, Li-Hua Pan, Xue-Qiang Zha, Jian-Ping Luo

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Laminaria japonica; polysaccharide; chronic renal failure

Online: 22 January 2019 (11:50:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0609.v1

Treatment-Free Remission in Chronic Myeloid Leukaemia: Can We Identify Prognostic Factors?

Hilbeen Hisham Saifullah, Claire Marie Lucas

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic myeloid leukaemia; chronic phase; Tyrosine kinase inhibitor; Treatment free remission; deep molecular response; BCR-ABL.

Online: 25 June 2021 (08:13:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0301.v2

Therapeutic Effects of Traditional Chinese Medicine Formula Qianlie Tongli Decoction on Chronic Prostatitis/Chronic Pelvic Pain Syndrome Induced by Peptide T2 in Mice

Xingxing Cui, Muhammad Naveed, Mirza Muhammad Faran Ashraf Baig, Wenlu Wang, Reyaj Mikrani, Ziwei Liu, Bilal Ahmed, Meng Tang, Junaid Wazir, Xiaohui Zhou

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Qianlie Tongli decoction; chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); anti-inflammation; therapeutic effects; immunization

Online: 24 April 2020 (04:30:56 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1619.v1

A Rare Onset of T Lymphoid Blast Crisis in Chronic Myeloid Leukemia with Two Distinct Blast Populations

Alessandra Mongia, Francesca Romano, Sara Ciullini Mannurita, Benedetta Peruzzi, Sara Bencini, Daniela Parrini, Laura Fasano, Alessandra Fanelli

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; T lymphoid blastic crisis

Online: 27 March 2024 (06:21:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1023.v1

The Potential Role of Stem Cells in Wound Healing: A Systematic Review

Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai

Subject: Medicine And Pharmacology, Dermatology Keywords: stem cells; chronic wound; wound healing; dermatology

Online: 19 February 2024 (08:19:53 CET)

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Introduction: Wound healing is a complex cascade involving the orchestration of inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. These cells achieve tissue repair through an interchange of cytokines and growth factors through a controlled inflammation, angiogenesis, and remodeling process. Disruptions in the wound-healing process by comorbid conditions lead to significant morbidity and mortality. Stem cell therapy has emerged as a new strategy to facilitate the wound healing process. Stem cells harvested from different sources can be used for wound repair and regeneration (endothelial progenitor cells, bone marrow, adipose tissue, dermal and inducible pluripotent stem cells). We aimed to review clinical, translational, and primary literature on stem cell therapies in chronic wounds and summarize practical clinical applications to dermatological care. Materials and Methods: A comprehensive search of Pubmed, Embase, Web of Science, Google Scholar, and Cochrane Library was conducted for studies relating to stem cells and wound healing. Duplicate results were removed using Covidence. Titles and abstracts were screened by two independent researchers (BF and KR), with discrepancies resolved through discussion and mutual agreement. Articles were excluded if they were review-type or commentary-type articles. Results: A total of 22,454 articles were retrieved from the search. Deduplication removed 905, and automation removed an additional 18,363 articles. After an initial screening of titles and abstracts, 170 articles remained. Full-text screening resulted in an additional 126 articles being removed, leaving 44 included studies. Discussion: Stem cells used for wound repair and regeneration include endothelial progenitor stem cells and adult stem cells, in the forms of bone marrow-derived mesenchymal stem cells, adipose tissue stem cells, and inducible pluripotent stem cells. Among these sources, adipose tissue-derived mesenchymal stem cells (AD-MSCs) are ideally used due to the abundant supply of fat tissue, ease of isolation, extensive proliferative capacities ex vivo, and their ability to secrete pro-angiogenic factors. AD-MSCs have been used to enhance wound healing in peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and postsurgical wounds after Mohs micrographic surgery. These cells have been delivered to the tissue topically, with scaffolds, combined with plasma-rich proteins, and through atelocollagen in various human studies. These approaches, when combined with local wound care practices, resulted in decreased pain, shorter wound healing times, and better cosmesis. Conclusions: Stem cell transplantation is a potential therapeutic approach in the wound healing process. Transplanted stem cells do not only differentiate into multiple skin cell types but also provide cytokine and growth factors required for wound healing resulting in increased angiogenesis. Thus, this approach may be regarded as an attractive option for intractable wounds that cause major clinical problems, especially chronic lower leg wounds. It can also be used after Mohs micrographic surgery for defects left to heal by secondary intention. Stem cell application may reduce the overall cost burden on the healthcare system and improve the quality of life for patients.

Preprint REVIEW | doi:10.20944/preprints202401.1632.v1

The Efficacy of a Novel Compound from Bovine Milk Colostrum Exosomes and Its Growth Factors in Enhancing the Process of Wound Healing

Mojgan Najafzadeh, Shohreh Jafarinejad, Adi Baumgartner, Jacobo Elies Gomez

Subject: Medicine And Pharmacology, Dermatology Keywords: Bovine Colostrum; Wound healing; Repair; Chronic wound

Online: 23 January 2024 (07:27:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0959.v1

Unraveling the Complex Web of Fibromyalgia: A Narrative Review

Sarah Al Sharie, Scott J. Varga, Lou’i Al-Husinat, Piercarlo Sarzi-Puttini, Mohammad Araydah, Batool Riyad Bal’awi, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: Fibromyalgia, Chronic pain, Diagnosis, Management, Emerging treatments.

Online: 12 January 2024 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2155.v1

Effects of Beraprost with or without NOS Inhibitor on Aldosterone and Hemodynamics in Healthy Cats

Takumi Matsuura, Aritada Yoshimura, Ryuji Fukushima

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: beraprost; feline; chronic kidney disease; aldosterone; NOS

Online: 30 September 2023 (05:18:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0063.v1

A Systematic Review and Network Meta-Analysis of Minimally Invasive Intervention Use in Pain Management

Ashish Shetty, Gayathri Delanerolle, Heitor Cavalini, Yinshan Qui, Amy Boyd, Yassine Bouchareb, Anish Thillainathan, Seung Kim, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: chronic pain; non-pharmaceutical pain management; interventions

Online: 1 June 2023 (08:13:11 CEST)

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Background: Chronic, non-cancer pain represents a serious public health and economic issue affecting approximately 20% of the global population. Chronic pain can affect many aspects of patient’s lives, including mental health, employment, and relationships. Current medical management is largely focussed on investigating and managing acute pain. Patients and clinicians are now increasingly aware of the potential benefits of combined treatments or complex interventions in alleviating chronic pain. These approaches include both physical interventions, such as exercise or yoga, as well as psychological support including cognitive behavioural therapy (CBT) and talking therapies. Methods: This study used network meta-analyses to explore the prevalence of complex interventions in pain management, and the effects of these interventions on quality of life, using outcome measures including intensity of chronic pain, assessment of functional disability and participant’s psychological state. Results: Psychological interventions were associated with improvements in pain intensity and depression. Exercise and manipulation technique-based treatments provided a statistically significant reduction in pain intensity. This effect was enhanced when exercise and CBT were combined. Mensendieck somatocognitive therapy (MSCT) plus standard gynaecological treatment (STGT) treatments appeared to have a better effect on chronic pain than multimodal exercise plus CBT treatment. Combined MSCT and STGT treatment, and multimodal exercise plus CBT treatments, reduced pain intensity, whilst MSCT+STGT treatments had a slightly better effect than exercise plus CBT treatment.Conclusions: Complex interventions have become more popular with patients as the risks associated with other interventions including surgery and pharmacological management have become better understood. These interventions can have a significant positive effect both on the physical and psychological health of patients. The analysis presented in this study suggests that further work is warranted in this area and that additional studies are required, both in more geographically diverse locations, and with larger cohorts.

Preprint COMMUNICATION | doi:10.20944/preprints202305.1381.v1

Chronic Viral Hepatitis in Children: Socio-Economic Implications in Romania

Irina Dijmărescu, Alexandra Coroleuca, Adrian Dumitru Dijmarescu

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic viral hepatitis; socio-economic status; children

Online: 19 May 2023 (05:07:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1093.v1

Microglial Responses to Stress-Induced Depression: Causes and Consequences

Ruqayya Afridi, Kyoungho Suk

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chronic stress; depression; microglia; neuroinflammation; proinflammatory cytokines

Online: 28 April 2023 (03:28:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0168.v1

Microbiome Responses to Fecal Microbiota Transplantation in Cats with Chronic Digestive Issues

Connie Rojas, Zhandra Entrolezo, Jessica K. Jarett, Guillaume Jospin, Dawn Kingsbury, Alex Martin, Jonathan A. Eisen, Holly H Ganz

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: fecal microbiota transplant; domestic cat; chronic enteropathies

Online: 10 January 2023 (02:15:25 CET)

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There is growing interest in the application of fecal microbiota transplants (FMTs) in small animal medicine, but there are few published studies that have tested their effectiveness in the domestic cat (Felis catus). Here we use 16S rRNA gene sequencing to examine fecal microbiome changes in 68 domestic cats with chronic digestive issues that underwent FMT treatment using lyophilized stool that was delivered in oral capsules. Fecal samples were collected from FMT recipients before and two weeks after treatment, as well as from their stool donors, and healthy animals. We found that according to their owners, 77% of cats were reported to show improvement in their clinical signs (termed ‘Responders’), and 23% were reported to exhibit no change or a worsening of their clinical signs (termed ‘Non-Responders’). Variation in the fecal microbiomes of FMT recipients most strongly correlated with host clinical signs, diet, and IBD diagnosis. The relative abundances of Collinsella, Negativibacillus, Parabacteroides, and Peptoclostridium changed differentially in FMT recipients. Overall, on average 13% of the bacterial amplicon sequence variants (ASVs) were shared between stool donors and FMT recipients (excluding ASVs already present in FMT recipients prior to treatment). The most commonly shared ASVs were classified as Prevotella 9, Peptoclostridium, Bacteroides, Collinsella and unclassified Lachnospiraceae. Lastly, FMT recipients that had recently taken antibiotics exhibited increases in microbiome similarity to an age-matched healthy reference set compared to other cats. Cats that had diarrhea or diarrhea with vomiting became more similar to healthy cats than did cats exhibiting other clinical signs. Overall, our results suggest that oral capsule FMT treatment was effective in this group of cats and microbiome responses may be modulated by the FMT recipient’s initial presenting clinical signs, prior IBD diagnosis, recent antibiotic use, and their diet.

Preprint ARTICLE | doi:10.20944/preprints202211.0365.v2

Chronic Inflammation and Blood Cancer

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: blood cancer; chronic inflammation; inflammation; mutation; tumor

Online: 24 November 2022 (02:55:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0341.v1

Regulation and Impact of Hepatitis B x Protein in Persistence and Oncogenesis of Hepatitis B Virus

Garima Garg, Shashank Purwar, Anirudh K. Singh, Ashish Kumar Vyas

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis B Virus; Chronic Hepatitis infection; Oncogenesis

Online: 22 July 2022 (13:18:26 CEST)

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Working Paper ARTICLE

Gut Microbiota as a Source of Uremic Toxins

Vasily A Popkov, Anastasia A Zharikova, Evgenia A Demchenko, Nadezda V Andrianova, Dmitry B Zorov, Egor Y Plotnikov

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: uremia; uremic toxins; microbiome; chronic kidney disease

Online: 14 July 2021 (13:04:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0645.v1

Can a single trial of a thoracolumbar myofascial release technique reduce pain and disability in chronic low back pain? Randomized balanced cross-over study

Luana Rocha Paulo, Ana Cristina Rodrigues Lacerda, Fábio Luiz Mendonça Martins, José Sebastião Cunha Fernandes, Leonardo Sette Vieira, Cristiano Queiroz Guimarães, Sílvia de Simoni Guedes Ballesteros, Marco Túlio Saldanha dos Anjos, Patrícia Aparecida Tavares, Sueli Ferreira da Fonseca, Murilo Xavier Oliveira, Mário Bernardo-Filho, Danúbia da Cunha de Sá-Caputo, Vanessa Amaral Mendonça, Redha Taiar

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: fascia; chronic low back pain; myofascial release

Online: 25 March 2021 (16:24:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0577.v1

Association of Edentulism With Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey

Alejandro José Casanova-Rosado, Juan Fernando Casanova-Rosado, Mirna Minaya-Sánchez, José Luís Robles-Minaya, Juan Alejandro Casanova-Sarmiento, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Horacio Isla-Granillo, Mariana Mora-Acosta, Sonia Márquez-Rodríguez, Carlo Eduardo Medina-Solís, Gerardo Maupomé

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Oral health; edentulism; chronic diseases; elders; Mexico

Online: 24 March 2021 (11:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0186.v1

Microglia and Inhibitory Circuitry in the Medullary Dorsal Horn: Laminar and Time-Dependent Changes in a Trigeminal Model of Neuropathic Pain

Nuria García-Magro, Yasmina B. Martin, Pilar Negredo, Francisco Zafra, Carlos Avendaño

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic pain; allodynia; trigeminocervical complex; glycine transporters

Online: 5 March 2021 (11:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0199.v1

Clinicopathological Variables and Outcome in Chronic Phase Chronic Myeloid Leukemia Associated with BCR-ABL1 Transcript Type and Body Weight

Mohammad Abdulla, Prem Chandra, Susanna El Akiki, Claudio Sorio, Luisa Tomasello, Christian Boni, Mohamed Yassin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; BCR-ABL1 transcript; obesity

Online: 7 August 2020 (13:07:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0235.v1

The Cost of Chronic Wounds in Argentina: An Estimation of the Burden in a Public Hospital

Romina Chavez-Jara, Nicolas Cerusico, Maria Lazarte, Carla Cabrera, Andrea Herrera Bruno, Eugenia Sesto Cabral, Alberto Nicolas Ramos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic wound; hospital cost; epidemiology; public health

Online: 20 May 2019 (09:53:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0028.v2

Motivating Diabetic and Hypertensive Patients to Engage in Regular Physical Activity: A Multi-Component Intervention Derived from the Concept of Photovoice

Angela Y. M. Leung, Pui Hing Chau, Isaac S. H. Leung, Michael Tse, Perick Lai Choi Wong, Wai Ming Tam, Doris Y. P. Leung

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: photovoice; chronic illness; physical activity; barriers; facilitator

Online: 2 April 2019 (07:48:28 CEST)

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Aims: A community-based multi-component intervention (increasing awareness of the importance of physical activity in chronic illness management through reading comic books, training regarding warm-up stretching exercises, identifying facilitators and barriers to exercise through photosharing, supporting self-reflection and development of action plans) was developed to promote physical activity (PA) among patients with diabetes and hypertension. This study aimed to evaluate the efficacy of this intervention on health behaviour (walking) and health outcomes. Design: A non-randomized controlled trial with waitlisted control and pre- and post-measures. Setting: Community centres for the elderly. Participants: A total of 204 older adults with diabetes and/or hypertension were recruited. They were assigned to either the intervention group (IG) or waitlisted to the control group (CG). Intervention: Under the supervision of a nurse, six weekly group meetings were arranged in community centres for the elderly in which the participants freely exchanged their views regarding the barriers and facilitators of regular physical activity. Participants were encouraged to take photos in their neighbourhood or at home and brought these photos to share at the group meetings. The photos showed both the barriers and the facilitators to PA. In the last meeting, each participant worked out a plan to perform PA in the coming four weeks. Measures: PA referred to the number of steps taken per day and it was measured by a Garmin Accelerometer at baseline, Week 6 and Week 10. Other measures included the nine-item Self-Efficacy Scale for Exercise - Chinese version (SEE-C), the 23-item Chinese Barriers to Exercise Scale and Senior Fitness Tests. Generalised Estimating Equations (GEE) models compared the outcomes over time between IG and CG. Results: A statistically significant difference in the changes in the average number of steps taken daily between the two groups at Week 10 (mean difference = 965.4; 95% confidence interval: 92.2, 1838.6, p = 0.030) was observed, although the difference at Week 6 was non-significant (mean difference = 777.6; 95% confidence interval: −35.3, 1590.5, p = 0.061). IG participants also showed significant improvements in lower body strength (mean difference = 0.967; 95% confidence interval: 0.029, 1.904, p = 0.043) and lower limb flexibility (mean difference = 2.068; 95% confidence interval: 0.404, 3.731, p = 0.015) at Week 10 compared to CG participants. Conclusion: This multi-component intervention improved the participants’ physical activity level and physical fitness, particularly in lower limb flexibility and body strength.

Preprint ARTICLE | doi:10.20944/preprints201807.0545.v1

Can the Mindful Awareness and Resilience Skills for Adolescents (MARS-A) program be provided online? Voices from the Youth

Nicholas Chadi, Elli Weisbaum, Catherine Malboeuf-Hurtubise, Sara Ahola Kohut, Christine Viner, Miriam Kaufman, Jake Locke, Dzung X. Vo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: qualitative, mindfulness, meditation, chronic illness, adolescents, eHealth

Online: 27 July 2018 (15:34:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0340.v1

The Efficacy and Safety of High Dose Cholecalciferol Therapy in Hemodialysis Patients

Agnieszka Tarasewicz, Michał Komorniczak, Agnieszka Zakrzewska, Bogdan Biedunkiewicz, Sylwia Małgorzewicz, Magdalena Jankowska, Katarzyna Jasiulewicz, Natalia Płonka, Małgorzata Dąbrowska, Alicja Dębska-Ślizień, Leszek Tylicki

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: vitamin D; cholecalciferol; 25-hydroxycholecalciferol, calcidiol; calcitriol; hemodialysis; parathyroid hormone; chronic kidney disease; chronic kidney disease–mineral; bone disorder

Online: 7 November 2023 (02:38:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0100.v1

Electrocardiogram, Echocardiogram and NT-proBNP in Screening for Thromboembolism Pulmonary Hypertension in Patients after Pulmonary Embolism

Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Iwona Dudzik-Niewiadomska, Michał Machowski, Marek Roik, Małgorzata Wiśniewska, Jan Siwiec, Izabela Magdalena Staniszewska, Piotr Pruszczyk

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: screening after pulmonary embolism; chronic thromboembolic pulmonary disease; chronic thromboembolic pulmonary hypertension; diagnostic work-up of post-pulmonary syndrome

Online: 9 October 2022 (02:09:20 CEST)

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Background: The annual mortality of patients with untreated chronic thromboembolism pulmonary hypertension (CTEPH) is approximately 50% unless a timely diagnosis is followed by adequate treatment. In pulmonary embolism (PE) survivors with functional limitation the diagnostic work-up starts with echocardiography. It is followed by lung scintigraphy and right heart catheterization. However, noninvasive test providing diagnostic clues to CTEPH, or ascertain this diagnosis as very unlikely, would be extremely useful since the majority of post PE functional limitations is caused by deconditioning. Methods: Patients after acute PE underwent a structured clinical evaluation with electrocardiogram, routine laboratory tests including NT-proBNP and echocardiography. The aim of study was to verify whether the parameters from echocardiographic or perhaps electrocardiographic examination and NT-proBNP concentration best determine the risk of CTEPH. Results: A total (n = 261, male n = 123) patients after PE were included into the study, in group of 155 patients (59.4%) with reported functional impairment 13 patients (8.4%) had CTEPH and 7 PE survivors had chronic thromboembolic pulmonary disease (CTEPD) (4,5%). Echo parameters differed significantly between CTEPH/CTEPD cases and other symptomatic PE survivors. Patients with CTEPH/CTEPD had also higher level of NT-proBNP (p = 0.022) but concentration of NT-proBNP above 125 pg/ml did not differentiate patients with CTEPH/CTEPD (p>0.05). Additionally, proportion of patients with right bundle brunch block registered in ECG was higher in group with CTEPH/CTED (23.5% vs. 5.8%, p = 0.034) but there were no differences between other ECG characteristics of right ventricle overload. Conclusion: Screening for CTEPH/CTEPD should be performed in patients with reduced exercise tolerance compared to pre PE period, It is not effective in asymptomatic PE survivors. Patients with CTEPH/CTED had predominantly abnormalities indicatingchronic thromboembolism in the echocardiographic assessment. NT-proBNP and electrocardiographic characteristics of right ventricle overload proved to be insufficient in predicting CTEPH/CTEPD development.

Preprint REVIEW | doi:10.20944/preprints202404.0471.v1

Integrative Chronic Pain Management: A Narrative Review

Matthew Halma, Paul Marik, Yusuf M. Saleeby, Jack A. Tuszynski

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: chronic pain; opioid use disorder; musculoskeletal disorders; injury

Online: 7 April 2024 (10:56:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0306.v1

Putting Functional Gastrointestinal Disorders within the Spectrum of Inflammatory Disorders Can Improve Classification and Diagnostics of These Disorders

Šojat Dunja, Volarić Mile, Tanja Keškić, Nikola Volarić, Venija Cerovečki, Ljiljana Majnarić Trtica

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: gastrointestinal diseases; chronic diseases; cytokines; gastrointestinal microbiome; inflammation

Online: 6 March 2024 (10:57:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0307.v1

Sleep Patterns of Children and Adolescents with Chronic Conditions and Their Families: An Integrative Literature Review

Welker da Silva Xavier, Madalena Paulos Abreu, Michelle Darezzo Rodrigues Nunes, Fernanda Machado Silva-Rodrigues, Liliane Faria Da Silva, Barbara Bertolossi Marta De Araújo, Paula Saud De Bortoli, Lucila Castanheira Nascimento

Subject: Public Health And Healthcare, Nursing Keywords: child; adolescent; family; chronic disease; sleep-wake disorders

Online: 4 January 2024 (15:17:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0145.v1

Associations between Physical Disability and Chronic Diseases with Depressive Symptoms in Vietnamese-Origin Older Adults in the United States

Christina E Miyawaki, Joshua M Garcia, Luis D Medina, Kim N Nguyen, Oanh L Meyer, Kyriakos S Markides

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic diseases; depressive symptoms; disability; older adults; Vietnamese

Online: 3 January 2024 (08:39:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1875.v1

Neuromodulation Techniques for Headache Management

Noora Reffat, Carolina Pusec, Scott J Price, Mayank Gupta, Philippe Mavrocordatos, Alaa Abd Elsayed

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: headache; migraine; chronic cluster headache; neuromodulation; pain management

Online: 29 November 2023 (10:39:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1358.v1

A Study on Mortality Predictors in Hemodialysis Patients Infected with COVID-19: Impact of Vaccination Status

Voin Brkovic, Gorana Nikolic, Marko Baralić, Milica Kravljava, Marija Milinkovic, Jelena Pavlovic, Mirjana Lausevic, Milan Radovic

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Covid-19; vaccines; chronic kidney disease; hemodialysis; lymphocytopenia

Online: 22 November 2023 (07:39:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1522.v1

A Review and Meta-Analysis of the Effect of Atenolol on All-Cause Mortality Risk among Asians With Chronic Progressive Diseases

Abdullah Alkattan, Eman Alsalameen, Alaa Harmoush, Mhd Nour Farawati, Hind Alsharif, Nagla Mahmoud, Mhd Ali Farawati, Amjad Alfaleh, Mahmoud Kandeel, Nashwa Radwan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Atenolol; mortality; Asians; chronic progressive disease; cardiovascular disease

Online: 22 September 2023 (04:36:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0253.v1

Links between Serotonin Levels and Stress: Cortisol, Candida A./Mycetes, Omega 3/6 Ratio and Dysbiosis (Skatole/Indoxyl Sulfate) Role in Chronic Fatigue Syndrome (CFS) and Depression

Daniele Orlandoni, Giuseppe Di Fede, Mauro Mantovani, Consuelo Rubina Nava, Marco Tomasi, Paola Fusi

Subject: Biology And Life Sciences, Other Keywords: stess; chronic fatigue syndrome; depression; dysbiosis; serotonin/cortisol

Online: 5 September 2023 (07:52:50 CEST)

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Intestinal microbiota attracts daily attention of a growing number of study which have attempted to link gut dysbiosIs with a variety of disease states: irritable bowel syndrome (IBS), inflamed bowel disease (IBD), Crohn's disease (CD), leaky gut syndrome (LGS), food intolerance, diabetes, metabolic syndrome, cancer, etc.. In our study we analyzed how intestinal dysbiosis may be related to chronic fatigue syndrome (CFS) and depression through the exchange of information through the gut-brain axis (GBA). We studied 33 subjects, 13 males and 20 females, who reported CFS or/and depression: we investigated their salivary cortisol levels, blood serotonin, omega 3/6 ratio, intestinal dysbiosis (calculated on the urinary levels of indoxyl sulfate and skatole), and we looked for the presence of Candida a. or mycetes in the stool; the data accumulated with this research show a correlation between the presence of Candida a./miceti, indoxyl sulfate urine values beyond the physiological and low serotonin levels. In addition, data analysis showed that the EPA/DHA values also show pro-inflammatory levels in case of dysbiosis and low serotonina levels. The relationship, however, with cortisol levels requires further research although this study showed a statistically significant positive correlation between these values, measured at specific times, and serotonin levels. Aims its connections with We investigated the relationship between stress (evaluated through the measurement of salivary cortisol levels) and gastrointestinal efficiency measured as a function of intestinal fermentative and putrefactive dysbiosis, evaluating the levels of urinary indoxyl sulfate in the first case (a possible correlation with the presence of Candida spp or Mycetes in the subjects feces was investigated), urinary skatole levels in the second one, in patients with chronic fatigue syndrome (SFC) and depression. In these patients we also have studied omega 3/6 ratio, and finally we have analized the impact that the alteration of these parameters can have on the serotonin levels. This research attemps to highlight the contact points, in some cases not so obvious, among these topics, contact points that, although they give us interesting indications, show the need to be further deepened by analyzing a larger amount of data.

Preprint ARTICLE | doi:10.20944/preprints202308.1662.v1

A Systematic Review and Meta-Epidemiology study on Multimorbidity

Gayathri Delanerolle, Yassine Bouchareb, Priyanka Jagadeesan, Guanpeng Li, Xiaojie Yang, Heitor Cavalini, Shaheen Kazali, Alain Zemokoho, David Benfield, Ashish Shetty, Peter Phiri, Jian qing Shi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Multimorbidity; Chronic condition; Health Inequalities; Global health; Epidemiology

Online: 23 August 2023 (11:25:08 CEST)

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With enhanced life expectancy and ageing global populations, the prevalence of multimorbidity continues to increase. However, there is a dearth of evidence linked to multimorbidity diagnoses, treatments and health outcomes which remains a concern for future proofing optimal healthcare services. Generating evidence is critical to managing multimorbidity, promoting public health and minimizing health inequalities via effective healthcare policies that improve quality of life for vulnerable populations. This study assessed meta-epidemiology of multimorbidity to report the gaps in scientific knowledge and clinical practice. A systematic methodology was designed and published in PROSPERO (CRD42022347308) to report meta-epidemiology analyses using databases including PubMed, Web of Science, ScienceDirect, EMBASE, The Cochrane Gynaecology and Fertility Group Specialised Register of Controlled Trials and MEDLINE for studies published between the 1^st of January 1980 - 31^st December 2022. A random-effects model was used to estimate the pooled proportion of multimorbidity in adults. Forest plots, pooled odds ratios and statistical heterogeneity metrics were used to assess the association between multimorbidity and investigated factors. Funnel plots and Egger’s regression were used to detect and correct for publication bias. Our findings identified women to be 0.32 times more likely to have multimorbidity in comparison to males. In regard to ethnicity, white people were 0.47 times less likely to develop comorbidities than black people. People who identified as a drinker or unmarried were more likely to develop comorbidities than those who are non-drinkers or married, respectively. Regardless of smoking status, people were equally likely to have comorbidity. In terms of environmental influences, people in rural areas were found to be 0.2 times less likely to have comorbidity in comparison to those living in urban areas. Interestingly, people with a higher education level were 0.57 times more likely to develop comorbidities than those with only a high school education. It is evident that multimorbidity has a significant burden globally and impacts the provision of care necessitated across populations given its association with several social determinants of health. Robust research and healthcare policies are required to better manage multimorbidity in patients. An example of such intervention includes employing prevention programs to reduce risk and incidence of multimorbidity within at-risk populations.

Preprint ARTICLE | doi:10.20944/preprints202307.2096.v1

The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats- a Long-Term Study

Brian G Murphy, Diego Castillo, Sarah Elisabeth Cook, Chrissy Eckstrand, Samantha Evans, Ellen Sparger, Chris Grant

Subject: Biology And Life Sciences, Virology Keywords: Cat; FIV; lentivirus; FAIDS; lymphoma; chronic renal failure

Online: 31 July 2023 (10:29:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1434.v1

Exploring Chronic Patients' Views and Perceptions on Life Constraints and Self- Management Strategies. A Qualitative Study

Michael Rovithis, Sofia Koukouli, Alexios Dimitropoulos, Argyroula Kalaitzaki, Nikos Rikos, George Vasilopoulos, Aikaterini Papachristou, George Tsolas, Alexandra Tamiolaki, Eleni Tsapnidou, Anastasia Dimitrantzou, Dimitrios Katsiris, Elli Katsiri, Areti Stavropoulou

Subject: Public Health And Healthcare, Other Keywords: chronic disease; self-management; elder patients; qualitative study

Online: 21 June 2023 (08:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1753.v1

A Systematic Review and Bayesian Meta-Analysis of Medical Devices Used in Chronic Pain Management

Ashish Shetty, Gayathri Delanerolle, Chunli Deng, Heitor Cavalini, Xiaojie Yang, Anish Thillainathan, Yassine Bouchareb, Amy Boyd, Peter Phiri, Jian Shi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Chronic pain; Medical Devices; Neuromodulation; Clinical trials; Bayesian

Online: 25 May 2023 (07:27:31 CEST)

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Chronic non-cancer pain is a highly debilitating condition affecting approximately 20% of the global population. Chronic pain may lead to significant physical disability, emotional distress, social isolation and financial burden. Whilst^.pharmacological therapies remain the cornerstone of pain management in non-cancerous chronic pain, factors including the current opioid epidemic have led to non-pharmacological techniques becoming a more attractive proposition. We explored the prevalence of medical device use and their treatment efficacy in non-cancer pain management. A systematic methodology was developed, peer reviewed and published in PROSPERO (CRD42021235384). Key words of medical device, pain management devices, chronic pain, lower back pain, back pain, leg pain and chronic pelvic pain using Science direct, PubMed, Web of Science, PROSPERO, MEDLINE, EMBASE, PorQuest and ClinicalTrials.gov. All clinical trials, epidemiology and mixed methods studies that reported the use of medical devices for non-cancer chronic pain management published between the 1^st of January 1990 and the 30^th of April 2022 were included. 13 studies were included in systematic review, of these 6 were used in the meta-analysis with 173 participants. Our meta-analysis for pain reduction in each study showed that transcutaneous electrical nerve stimulation combined with instrument-assisted soft tissue mobilization treatment and pulsed electromagnetic therapy produced significant treatment on chronic lower back pain patients. Pooled evidence revealed the use of medical device related interventions resulted in 0.7 degree of pain reduction under a 0-10 scale. Significant improvement in disability scores, with a 7.44 degree reduction in disability level compared to a placebo using a 50 score range was also seen. The application of medical devices in patients with chronic pain has gained popularity due to increasingly cost effective techniques, minimally invasiveness and greater awareness of risks associated with pharmacological management. Our analysis has shown that the optimal use of medical devices in a sustainable manner requires further extensive research, needing larger cohort studies with greater gender parity, in a more diverse range of geographical locations.

Preprint REVIEW | doi:10.20944/preprints202305.0643.v1

Cells and Processes in Wound Healing: More Recent Advances

Montserrat Fernández-Guarino, María Luisa Hernández-Bule, Stefano Bacci

Subject: Biology And Life Sciences, Life Sciences Keywords: Acute Wounds; Cellular Infiltrate; Chronic Wounds; Keloids; Scars

Online: 9 May 2023 (11:06:05 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202305.0453.v1

Development of a Modified Global Physical Activity Questionnaire and its Construct Validity among Adults in Kerala, India

Thirunavukkarasu Sathish, Elezebeth Mathews

Subject: Public Health And Healthcare, Other Keywords: physical activity; GPAQ; validity; self-reports; chronic diseases

Online: 8 May 2023 (05:20:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0158.v1

Relationship between Joint and Ligament Structures of the Subtalar Joint and Degeneration of the Subtalar Articular Facet

Ryoya Togashi, Mutsuaki Edama, Mayuu Shagawa, Haruki Osanami, Hrotake Yokota, Ryo Hirabayashi, Chie Sekine, Tomonobu Ishigaki, Hiroshi Akuzawa, Yuki Yamada, Taku Toriumi, Ikuo Kageyama

Subject: Physical Sciences, Biophysics Keywords: subtalar joint instability; chronic ankle instability; footprint osteoarthritis

Online: 9 January 2023 (09:22:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0224.v1

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Varvara A Ryabkova, Natalia Y Gavrilova, Alina A Poletaeva, Aleksandr I Pukhalenko, Irina A Koshkina, Leonid P Churilov, Yehuda Shoenfeld

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: fibromyalgia; myalgic encephalomyelitis/chronic fatigue syndrome; autoantibodies; autoimmunity

Online: 13 December 2022 (02:47:48 CET)

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(1) Background: Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, natural AAb network is much more extensive, and has not been previously investigated in these disorders; (2) Methods: The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of a 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens a) in 11 FM patients with comorbid ME/CFS; b) in 11 ME/CFS patients without FM; c) in 11 healthy controls. Individual autoantibody profiles and their correlation with some clinical symptoms were analyzed. (3) Results: both patients with ME/CFS and ME/CFS+FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were changing in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental-health related quality of life. Notably, that widely different correlation patterns were observed between study groups. (4) Conclusions: Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may break down in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system's ability to reflect qualitative and quantitative changes in antigenic composition of the body.

Preprint ARTICLE | doi:10.20944/preprints202112.0415.v1

Multicenter Retro-Prospective Observational Study on Chronic Hypoparathyroidism and rhPTH (1-84) Treatment

Gemma Marcucci, Guglielmo Beccuti, Giulia Carosi, Filomena Cetani, Luisella Cianferotti, Anna Maria Colao, Carolina Di Somma, Mirko Duradoni, Antonia Elefante, Lucia Ghizzoni, Massimo Giusti, Andrea Gerardo Lania, Elisabetta Lavezzi, Bruno Madeo, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Simone Parri, Francesca Pigliaru, Assunta Santonati, Antonio Spada, Lara Vera, Maria Luisa Brandi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Chronic Hypoparathyroidism; rhPTH (1-84); Natpar®; Treatment

Online: 24 December 2021 (23:55:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0318.v1

Probiotics Role in Chronic Rhinosinusitis Treatment: an Update of the Current Literature

Maria Rita Bianco, Massimo Ralli, Domenico Michele Modica, Marta Amata, Salvatore Poma, Gianfranco Mattina, Eugenia Allegra

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chronic rhinosinusitis; probiotics; microbiome; nasal microbiota; microbiome therapy

Online: 21 October 2021 (23:00:15 CEST)

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Working Paper ARTICLE

Calcineurin Suppresses Cardiomyocyte-protective Autophagy Under Chronic Intermittent Hypoxia by Downregulating the AMPK Pathway

Sheng Xie, Wei Liu, Meng Jin, Xiaochen Li, Tao Wang, Shaolin Zeng, Hanxiang Nie, Zhao Dong, Zhenghua Ke, Ke Hu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic intermittent hypoxia; autophagy; apoptosis; cardiomyocyte damage; calcineurin

Online: 24 June 2021 (14:58:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0493.v1

Long-term recovery of the fecal microbiome and metabolome of dogs with steroid-responsive enteropathy

Rachel Pilla, Blake Guard, Amanda B Blake, Mark Ackermann, Craig Webb, Steve Hill, Jonathan A Lidbury, Joerg M Steiner, Albert Jergens, Jan Suchodolski

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Chronic diarrhea, idiopathic inflammatory bowel disease, microbiota, dysbiosis

Online: 21 June 2021 (08:56:30 CEST)

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Working Paper ARTICLE

Effects of Chronic Lithium Treatment on Anxious Behaviors and Serotonergic Genes Expression in the Midbrain Raphe Nuclei of Defeated Male Mice

Dmitriy A. Smagin, Irina L Kovalenko, Anna G. Galyamina, Irina V Belozertseva, Nikolay V Tamkovich, Konstantin O Baranov, Natalia N. Kudryavtseva

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic social defeat stress; anxiety; lithium chloride; mice

Online: 3 June 2021 (11:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0599.v1

Development of the Survey of the Concept of Pain: A Measure to Study How Children Conceptualize Pain

Isabel Salvat, Cristina Adillón, Eva Maria Andrés, Sonia Monterde, Jordi Miró

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Survey; children; health knowledge; chronic pain; pain education.

Online: 26 February 2021 (09:30:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0346.v1

A Highly Transparent and Explainable Artificial Intelligence Tool for Chronic Wound Classification: XAI-CWC

Salih Sarp, Murat Kuzlu, Emmanuel Wilson, Umit Cali, Ozgur Guler

Subject: Engineering, Control And Systems Engineering Keywords: Chronic wound classification; transfer learning; explainable artificial intelligence.

Online: 18 January 2021 (14:28:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0170.v1

Functional Disability in Adolescents with Chronic Pain: Comparing an Interdisciplinary Exposure Program to Usual Care

Carolien Dekker, Mariëlle Goossens, Bjorn Winkens, Silvia Remerie, Caroline Bastiaenen, Jeanine Verbunt

Subject: Social Sciences, Psychology Keywords: Chronic musculoskeletal pain; Adolescents; functional disability; multidisciplinary rehabilitation.

Online: 3 November 2020 (15:41:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0395.v1

Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Antonello Sica, Beniamino Casale, Caterina Sagnelli, Armando Calogero, Maria Teresa Di Dato, Alessandro Spada, Marco Rispoli, Mario Santagata, Pietro Buonavolontà, Alfonso Fiorelli, Vincenzo Tammaro, Massimo Ciccozzi, Anna Salzano, Evangelista Sagnelli, Elisabetta Saracco, Dario Tammaro, Alfonso Papa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: physical activity; elderly population; chronic pain; mediastinal lymphomas

Online: 30 December 2019 (09:44:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0435.v2

Assessment of Left Ventricular Diastolic Function in Children Undegoing Hemodialysis. A Mini Review

Ljiljana Sulovic, Vladimir Sulovic, Zorica Zivkovic, Maja Vasic, Nenad Sulovic

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: chronic kidney disease; hemodialysis; cardiovascular disease; echocardiography; child

Online: 4 July 2019 (10:37:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0001.v1

System-level Insights into the Adaptation of Domestic Dairy Buffalo to Chronic Heat Stress

Zhaobing Gu, Shoukun Tang, Xianhai Fu, Chuanbin Liu, Huaming Mao

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: chronic heat stress; dairy buffaloes; proteomics; adaptation mechanisms

Online: 3 January 2019 (08:32:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0448.v1

MERTK rs4374383 Polymorphism Predicts Progression of Liver Fibrosis in HCV-Infected Patients: A Longitudinal Study

Maria Angeles Jimenez-Sousa, Ana Zaida Gómez-Moreno, Daniel Pineda-Tenor, Oscar Brochado-Kith, Juan José Sánchez-Ruano, Tomás Artaza-Varasa, Alicia Gómez-Sanz, Amanda Fernández-Rodríguez, Salvador Resino

Subject: Biology And Life Sciences, Virology Keywords: liver stiffness; MERTK; chronic hepatitis C; cirrhosis; SNPs

Online: 19 October 2018 (10:56:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0396.v1

Smart Wound Dressings for Diabetic Chronic Wounds

Elizabeth Gianino, Craig Miller, Jordon Gilmore

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: diabetes; chronic wounds; smart wound dressing; biochemical sensor

Online: 28 May 2018 (10:22:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0137.v1

Burden of Serious Fungal Diseases in Romania

Mihai Mareș, Valentina Ruxandra Moroti-Constantinescu, David W. Denning

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: mycoses; epidemiology; Romania; candidaemia; aspergillosis; chronic pulmonary conditions

Online: 21 February 2018 (16:41:29 CET)

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Objective: To estimate for the first time the burden of serious fungal infections in Romania; Methods: Data derived from the World Health Organization (WHO), National Institute of Statistics, Romanian public health agencies and non-profit health organizations and published annual reports on local epidemiology were used in the present study. When no data was available, specific at-risk populations were used to calculate frequencies of serious fungal diseases, using previously published epidemiological parameters. All data refer to the year 2016; 3) Results: The estimated number of serious fungal infections in Romanian population was 435,930 in 2016. Recurrent vulvovaginal candidiasis accounts for up to 80% of total cases (more than 350,000 women annually). Concerning the HIV related infections, among 14349 infected persons, Pneumocystis pneumonia occurred in about 10% of late presenters (30 cases in 2016), while cryptococcal meningitis is rarely diagnosed (less than 20 cases). Annually, the total number of oesophageal candidiasis and oral thrush cases in HIV-positive patients may be as high as 1229 and 3066, respectively. In immunocompromised and cancer patient population, the annual incidence of candidaemia is 295, and at least 158 invasive aspergillosis cases and 4 mucormycosis cases occur yearly. With 4,966 critical care beds and approximately 200,000 abdominal surgeries performed, the estimated annual incidence of candidaemia and Candida peritonitis is 689 and 344, respectively. The annual incidence of pulmonary tuberculosis is still high in Romania (12,747 cases). Thus, the prevalence of post-TB chronic pulmonary aspergillosis is estimated to be 8.98/100,000 (1768 cases). The prevalence of chronic obstructive pulmonary disease (COPD) and asthma in adults is 6% and 6.5%, respectively. Therefore, allergic bronchopulmonary aspergillosis prevalence is estimated at 29,387 and severe asthma with fungal sensitisation at 38,731 cases annually. 4) Conclusions: Not being on the list of reportable diseases, the number of patients presenting with severe mycoses in Romania can only be roughly estimated. Based on local reports and prevalence estimation, we consider that at least 2.2% of Romanians suffer a serious form of fungal disease.

Preprint REVIEW | doi:10.20944/preprints201709.0146.v2

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina, Enric Espel

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment

Online: 29 September 2017 (03:17:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0220.v1

Service Innovations in Health Care Service Ecosystem: A Case Study

Maria Vincenza Ciasullo, Silvia Cosimato

Subject: Business, Economics And Management, Business And Management Keywords: innovation; service innovation; healthcare; chronic diseases; SD Logic

Online: 30 March 2017 (17:10:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0416.v1

Chronic Diseases Associated with Malassezia Yeast

Abdourahim Abdillah, Stéphane Ranque

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Malassezia; Chronic diseases; psoriasis; atopic dermatitis; chronic rhinosinusitis; asthma; cystic fibrosis; HIV infection; inflammatory bowel disease; colorectal cancer; neurodegenerative diseases

Online: 24 September 2021 (08:13:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0527.v1

Finite Mixture Models Based on Pain Intensity, Functional Disability and Psychological Distress Composite Assessment Allow to Identify Two Distinct Classes of Persistent Spinal Pain Syndrome after Surgery Patients Related to Their Quality of Life

Amine Ounajim, Maxime Billot, Pierre-Yves Louis, Yousri Slaoui, Denis Frasca, Lisa Goudman, Manuel Roulaud, Nicolas Naiditch, Bertille Lorgeoux, Sandrine Baron, Kevin Nivole, Mathilde Many, Nihel Adjali, Philippe Page, Bénédicte Bouche, Elodie Charrier, Laure Poupin, Delphine Rannou, Géraldine Brumauld de Montgazon, Brigitte Roy-Moreau, Chantal H. Wood, Raphael Rigoard, Romain David, Maarten Moens, Philippe Rigoard

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: PSPS; FBSS; chronic pain; health-related quality of life; mixture models analysis; personalized pain management; chronic pain after spinal surgery

Online: 27 August 2021 (15:23:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0392.v1

Incorporating Point-of-Care Bacterial Fluorescence into a Wound Clinic Antimicrobial Stewardship Program

Thomas Serena

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: antimicrobial stewardship; detection of bacteria in chronic wounds, chronic wounds, clinical decision support; diagnostic pathway; joint commission; fluorescence imaging; wound clinic

Online: 19 October 2020 (15:35:25 CEST)

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Background: In 2014 the World Health Organization (WHO) warned of an emerging world-wide crisis of antibiotic resistant microorganisms. In response, government and professional organizations recommended that health care systems adopt antimicrobial stewardship programs (ASPs). In the United States, the Centers for Medicare Services (CMS) mandated antimicrobial stewardship in the hospital inpatient setting. Effective January 1, 2020, the Joint Commission required ambulatory centers that prescribe antibiotics, such as wound centers, to institute an ASP. Chronic wounds often remain open for months, during which time patients may receive multiple courses of antibiotics and numerous antimicrobial topical treatments. The wound clinician plays an integral role in reducing antimicrobial resistance in the outpatient setting: antibiotics prescribed for skin and soft tissue infections are among the most common in an outpatient setting. One of the most challenging aspects of antimicrobial stewardship in treating chronic wounds is the inaccuracy of bacterial and infection diagnosis. Methods: Joint Commission lists five elements of performance (EP): (1) Identifying an antimicrobial stewardship leader, (2) establishing an annual antimicrobial stewardship goal, (3) implementing evidence-based practice guidelines related to the antimicrobial stewardship goal, (4) providing clinical staff with educational resources related to the antimicrobial stewardship goal, and (5) collecting, analyzing, and reporting data related to the antimicrobial stewardship goal. This article focuses on choosing and implementing an evidence-based ASP goal for 2020. Discussion: Clinical trials have demonstrated the ability of fluorescence imaging (MLiX) to detect clinically significant levels of bacteria in chronic wounds. Combined with clinical examination of signs and symptoms of infection, the MLiX procedure improves the clinician’s ability to diagnose infection and can guide antimicrobial use. In order to satisfy the elements of performance, the MLiX procedure was incorporated into the annual ASP goal for several wound care centers. Clinicians were educated on the fluorescence imaging device and guidelines were instituted. Collection of antimicrobial utilization data is underway.

Preprint ARTICLE | doi:10.20944/preprints202404.1629.v1

Burr Hole Craniostomy Versus Craniotomy for Chronic Subdural Hematoma – A Multicenter Study

Nenad Koruga, Djula Djilvesi, Anamarija Soldo Koruga, Vjekoslav Kopačin, Tatjana Rotim, Tajana Turk, Slavko Čičak, Josip Kocur, Marija Perić, Tomislav Ištvanić, Vedran Farkaš, Sonja Škiljić, Alen Rončević

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Burr hole craniostomy; Craniotomy; Chronic subdural Hematoma; Multicenter study

Online: 25 April 2024 (08:38:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0468.v1

Neuromodulation and Habituation: A Literature Review and Conceptional Analysis of Sustaining Therapeutic Efficacy and Mitigating Habituation

Anand S. Patil, Brittni Levasseur, Mayank Gupta

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: spinal cord stimulator; neuromodulation; explant; chronic pain; waveform; habituation

Online: 7 April 2024 (10:09:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1329.v1

A Review about Lateral Ankle Instability and Emerging Alternative Outcome Monitoring Tools in Patients Following Ankle Ligament Reconstruction Surgery

Ibrahim Saliba, Alexandre Hardy, Wenzheng Wang, Raphael Vialle, Sylvain Feruglio

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: ankle instability; chronic ankle instability; postoperative management; diagnostics; NIRS

Online: 18 December 2023 (12:45:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0113.v1

Neurosecretory Protein GM-Expressing Neurons Participate in Lipid Storage and Inflammation in Newly Developed Cre Driver Mice

Yuki Narimatsu, Masaki Kato, Eiko Iwakoshi-Ukena, Shogo Moriwaki, Ayano Ogasawara, Megumi Furumitsu, Kazuyoshi Ukena

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: neurosecretory protein GM; hypothalamus; neuropeptide; obesity; chronic inflammation; chemogenetics

Online: 2 November 2023 (07:43:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0374.v1

A Manifesto in Defense of Pain Complexity: A Critical Review of Essential Insights in Pain Neuroscience

Javier Picañol Párraga, Aida Castellanos Esparraguera

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: pain; chronic pain; nociception; sensory neuron; pain neuroscience education

Online: 9 October 2023 (09:31:37 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.1533.v1

Germline CSF3R Variant in Chronic Myelomonocytic Leukemia: Linking Genetic Predisposition to Uncommon Hemorrhagic Symptoms

Maria Teresa Bochicchio, Giorgia Micucci, Silvia Asioli, Martina Ghetti, Giorgia Simonetti, Alessandro Lucchesi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chronic myelomonocytic leukemia; CSF3R; bleeding disorders; predisposing genes; NGS

Online: 22 September 2023 (08:35:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1270.v1

Estimation of the Cadmium Nephrotoxicity Threshold from Loss of GFR and Albuminuria

Soisungwan Satarug, David A. Vesey, Tanaporn Khamphaya, Phisit Pouyfung, Glenda C. Gobe, Supabhorn Yimthiang

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: albuminuria; blood pressure; cadmium; chronic kidney disease; estimated GFR

Online: 17 August 2023 (08:07:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0843.v2

Zanubrutinib: Coming of Age for BTK Inhibitors in the Treatment of Chronic Lymphocytic Leukemia?

Stefano Molica, Constantine Tam, David Allsup, Aaron Polliack

Subject: Medicine And Pharmacology, Hematology Keywords: CLL, Zanubrutinib, BTK inhibitors, efficacy, safety, chronic lymphocytic leukemia

Online: 22 May 2023 (16:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0475.v2

Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon

Tatiane Lobato Da Silva, Apio Ricardo Nazareth Dias, Juarez Antônio Simões Quaresma, Luiz Fábio Magno Falcão

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis C virus; Genetic; Chronic Hepatitis C; Liver; Elastography

Online: 22 May 2023 (13:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0580.v1

Prevalence of Clinical Signs and Symptoms of Temporomandibular Joint Disorders Registered in the EUROTMJ Database: A Prospective Study in a Portuguese Center

David Faustino Ângelo, Beatriz Mota, Ricardo São João, David Sanz, Henrique José Cardoso

Subject: Medicine And Pharmacology, Surgery Keywords: Temporomandibular joint disorders; parafunctional habits; risk factors; chronic diseases

Online: 9 May 2023 (07:10:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0211.v1

Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience

Zhinei Tan, Yongxia Li, Yinzheng Guan, Javed Iqbal, Chenyue Wang, Xinming Ma

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: klotho; estrogen; hippocampus; chronic stress; sex difference; stress resilience

Online: 13 December 2022 (01:09:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0168.v1

The Impact of Spiritual-Based Care Interventions on the Quality of Life of Children with Chronic Diseases: a Philosophical Perspective

Idyatul Hasanah, Moses Glorino Rumambo Pandin, Tita Rohita

Subject: Public Health And Healthcare, Nursing Keywords: Nursing; Spiritual care; Quality of life; Chronic disease; Children

Online: 13 June 2022 (05:17:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0171.v1

The Antineoplastic Role of STAT5 Inhibition in BCRABL1-Positive Cells Exposed to Pimozide Alone and in Combination with Dasatinib and Ponatinib

Marco Santoro, Salvatrice Mancuso, Manlio Tolomeo, Rosaria Maria Pipitone, Stefania Grimaudo, Sergio Siragusa

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: chronic myeloid leukemia; dasatinib; ponatinib; pimozide; STAT inhibitors; K562

Online: 11 October 2021 (16:17:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0376.v1

Association of Migraine and Irritable Bowel Syndrome in Saudi Arabia: A Nationwide Survey.

Khalid A. Bin Abdulrahman, Nawaf S. Alenazi, Saad B. Albishri, Faisal F. Alshehri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Migraine; Headache; Irritable Bowel Syndrome; Chronic Pain; Saudi Arabia

Online: 18 August 2021 (11:21:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0205.v1

Different Lower Extremity Arterial Calcification Patterns in Patients with Chronic Limb-Threatening Ischemia Compared with Asymptomatic Controls

Louise CD Konijn, Richard AP Takx, Willem PThM Mali, Hugo TC Veger, Hendrik van Overhagen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic limb-threatening ischemia; peripheral arterial disease; calcification pattern

Online: 7 April 2021 (14:45:17 CEST)

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Objectives The most severe type of peripheral arterial disease (PAD) is critical limb ischaemia (CLI). In CLI, calcification of the vessel wall plays an important role in symptoms, amputation rate and mortality. However, calcified arteries are also found in asymptomatic persons (non-PAD patients). We investigated whether the calcification pattern in CLI patients and non- PAD patients are different and could possibly explain the symptoms in CLI patients. Materials and Methods 130 CLI and 204 non-PAD patients underwent a CT of the lower extremities. This resulted in 118 CLI patients (mean age 72±12, 70.3% male) that were age-matched with 118 non-PAD patients (mean age 71±11, 51.7% male). The characteristics severity, annularity, thickness and continuity were assessed in the femoral and crural arteries and analysed by binary multiple logistic regression. Results Nearly all CLI patients have calcifications and these are equally frequent in the femoropopliteal (98.3%) and crural arteries (97.5%), while the non-PAD patients had in just 67% any calcifications with more calcifications in the femoropopliteal (70.3%) than in the crural arteries (55.9%, p<0.005). The crural arteries of the CLI patients had significantly more complete annular calcifications (OR 2.92, p=0.001.) while in the non-PAD patients dot-like calcifications dominated. In CLI patients, the femoropopliteal arteries had more severe, irregular / patchy and thick calcifications (OR 2.40, 3.27, 1.81, p≤0.05, respectively) while in non-PAD patients, thin continuous calcifications prevailed. Conclusions Compared with non-PAD patients CLI patients are more frequently and extensively calcified. Annular calcifications were found in the crural arteries of CLI patients while dot-like calcifications were mostly present in the non-PAD patients. These different patterns of calcifications in CLI point at different etiology and can have prognostic and eventually therapeutic consequences.

Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0261.v1

Diagnostic Imaging in Pediatric Chronic Rhinosinusitis: A Guide for Clinicians

Giorgio Conte, Luca Caschera, Sandro Magnani, Claudia Cinnante, Fabio Maria Triulzi, Lorenzo Pignataro, Sara Torretta

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: rhinosinusitis; pediatric chronic rhinosinusitis; computed tomography; magnetic resonance imaging

Online: 26 June 2019 (07:21:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0033.v1

Viral Persistence and Chronicity in Hepatitis C Virus Infection: Role of T-Cell Apoptosis, Senescence and Exhaustion

Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson, Esaki Muthu Shankar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: apoptosis; viral persistence, hepatitis C virus; immunity; chronic infection

Online: 2 October 2018 (16:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0050.v1

The FDA and the State of Chronic Diseases: Cardiovascular, Endocrine, Pulmonary, and Renal Diseases

Mona Fiuzat, Michael P. Gray, Grace Anne Dorney Koppel, Aaron Kowalski, Prabir Roy-Chaudhury, Mary Norine Walsh, Daniel W. Jones, Enid Neptune, Robert Ratner, Melissa West, Brad A. Wong, Robert Califf

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic diseases; cardiovascular; renal; endocrine; diabetes; therapeutic advances; tobacco

Online: 3 May 2018 (05:08:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1646.v1

Predicting Cognitive Impairment in Patients with Chronic Traumatic Encephalopathy: A Single-Center Prospective Cohort Study

Khrystyna Duve, Pavlo Petakh, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: chronic traumatic encephalopathy; traumatic brain injury; cognitive impairment; logistic regression

Online: 25 April 2024 (08:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1507.v1

Optimizing Flexible Microelectrode Designs for Enhanced Efficacy in Electrical Stimulation Therapy

Lihong Qi, Ying Yu, Zeru Tao, Mujie Liu, Yongwei Jiang, Kai Yao, Yuheng Wang

Subject: Engineering, Electrical And Electronic Engineering Keywords: Flexible; Serpentine Structure; MEMS; Electrical Stimulation Therapy; Chronic Wound Healing

Online: 27 February 2024 (10:23:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1486.v1

Herpesvirus Infection as a Systemic Pathological Axis in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Jean M Nunes, Douglas B Kell, Etheresia Pretorius

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS); Endothelial cells; Herpesvirus

Online: 19 January 2024 (13:13:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0675.v1

Prevalence of Fetal Inflammatory Response Syndrome and Villitis of Unknown Etiology in the Placenta of Saudi Women and Their Association with Baby Gender

Waleed Mohammed Aldahmash, Khaldoon Aljerian, Saleh Hamed Alwasel

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Inflammatory Response Syndrome; VUE; chronic deciduitis; CD8; CD68; Placenta; gender

Online: 10 November 2023 (07:29:45 CET)

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Long-term health consequences are influenced by circumstances that occur during pregnancy. The confluence of the maternal and fetal circulations occurs at the placenta, which is the first or-gan to develop. Placental pathology can provide an accurate diagnosis of inflammation inside the amniotic sac. The pathological alterations of preterm placentas provide evidence for the causes of numerous perinatal pathologies, including spontaneous preterm births. This retrospec-tive study aimed to re-examine placentas regarded as normal by the Obstetrics and Gynecology Department in our institution so that grading and staging of any evident inflammatory response could be evaluated and associated with baby gender. Eighty-four full-term placentas were col-lected after delivery. Placentas that were considered normal and were not sent to the histo-pathology department were taken. Morphological examination of fresh placenta was conducted. Full thicknesses of placenta samples were taken from central and marginal regions of placental disc. Fetal and maternal inflammatory responses syndrome were assessed. Villitis of unknown etiology (VUE) and chronic deciduitis also were evaluated in the placenta. Immunohistochemis-try (IHC) was also performed to evaluate patterns of inflammation in the placenta using an-ti-CD8 and anti-CD68 antibodies. The correlation between the silent pathologies and clinical complications or involvement of developing fetal inflammatory response syndrome was meas-ured. In this study, seventeen (20%) maternal inflammatory samples and ten (12%) fetal inflam-matory samples showed inflammatory responses. The frequency of chronic deciduitis and villi-tis of unknown etiology was more remarkable among Saudi pregnant women than the previ-ously reported findings in the literature of placental pathology. The prevalence of fetal and ma-ternal inflammatory response was greater in the placentas of mothers of males than in placentas of female mothers. Grading placental inflammation usually predict the degree of maternal an-ti-fetal cellular rejection. Fetal inflammatory response syndrome usually goes unnoticed in Sau-di Arabia. There are differences in the inflammatory response in the placenta based on the sex of the newborn. Increasing the number of placental samples that must be sent for microscopic in-spection may be preferable due to their significance in identifying the causes of chronic disor-ders.

Preprint ARTICLE | doi:10.20944/preprints202310.1870.v1

Study on Mechanism of Lactobacillus rhamnosus Mitigating PFOA/PFOS Toxicity in Adult Zebrafish (Danio rerio)

Guanyi Li, Sibao Chen, Ruixuan Li, Mengyan Wang, Jinjin Li, Mengmeng Yi, Yingxue Sun, Chun Wang

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: PFOA; PFOS; Lactobacillus rhamnosus; Chronic toxicity; Oxidative stress; Gut microbiota

Online: 30 October 2023 (08:41:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1808.v1

Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of Depression

Chorpeth Chalermwongkul, Charinya Khamphukdee, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Juthamart Maneenet, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Oroxylum indicum, baicalein, unpredictable chronic mild stress, HPA-axis, depression

Online: 28 August 2023 (03:35:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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