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Preprint REVIEW | doi:10.20944/preprints202304.0543.v1

Adewale Adeniyi, Ibrahim Bello, Taofeek Mukaila, Niloy Sarker, Ademola Hammed

Subject: Engineering, Bioengineering Keywords: ammonia; bioprocessing; bioengineering; fermentation,; enzyme immobilization

Online: 19 April 2023 (04:42:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201909.0241.v1

Mechanotransduction in Neuronal Cell Development and Functioning

Matteo Chighizola, Tania Dini, Cristina Lenardi, Paolo Milani, Alessandro Podestà, Carsten Schulte

Subject: Biology And Life Sciences, Biophysics Keywords: mechanobiology; biophysics; neuronal differentiation; biomaterials; bioengineering

Online: 20 September 2019 (18:59:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1717.v2

Biodiversity as a Firewall to Engineered Microbiomes for Restoration and Conservation

Victor Maull, Ricard Sole

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Ecological networks; bioengineering; synthetic biology; invasion dynamics

Online: 24 October 2023 (16:46:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0149.v1

Approaches to Enhancing Bioproduction using Lignocellulose Biomass: A Major Focus on Biofuel Production

Emmanuel Ugwuoji, Levi Eruala, Chidinma Akpadolu, Kenechi Akpadolu

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Biogas; anaerobic digestion; gene mutation; bioengineering; lignocellulose biomass

Online: 11 October 2022 (10:33:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0417.v1

A Review on the Technological Advances and Future Perspectives of Axon Guidance and Regeneration in Peripheral Nerve Repair

Arjun Prasad Tiwari, Taylor Lokai, Bayne Albin, In Hong Yang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: axon guidance; peripheral nerves regeneration; bioengineering approach; optogenetic stimulation

Online: 24 August 2022 (08:39:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0061.v1

Conducting Wine Symphonics with the Aid of Yeast Genomics

Isak Pretorius

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: alcohol; aroma; bioengineering; flavour; synthetic genomics; taste; wine; yeast

Online: 10 December 2016 (09:09:54 CET)

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A perfectly balanced wine can be said to create a symphony in the mouth. To achieve the sublime, both in wine and music, requires imagination and skilled orchestration of artistic craftmanship. For wine, inventiveness starts in the vineyard. Similar to a composer of music, the grapegrower produces grapes through a multitude of specifications to achieve a quality result. Different Vitis vinifera grape varieties allow the creation of wine of different genres. Akin to a conductor of music, the winemaker decides what genre to create and considers resources required to realise the grape’s potential. A primary consideration is the yeast: inoculate the grape juice or leave it ‘wild’; which specific or combined Saccharomyces strain(s) should be used; or proceed with a non-Saccharomyces species? Whilst the various Saccharomyces and non-Saccharomyces yeasts perform their role during fermentation, the performance is not over until the ‘fat lady’ (S. cerevisiae) has sung (i.e. the grape sugar has been fermented to specified dryness and alcoholic fermentation is complete). Is the wine harmonious or discordant? Will the consumer demand an encore and make a repeat purchase? Understanding consumer needs lets winemakers orchestrate different symphonies (i.e. wine styles) using single- or multi-species ferments. Some consumers will choose the sounds of a philharmonic orchestra comprising a great range of diverse instrumentalists (as is the case with wine created from spontaneous fermentation); some will prefer to listen to a smaller ensemble (analogous to wine produced by a selected group of non-Saccharomyces and Saccharomyces yeast); and others will favour the well-known and reliable superstar soprano (i.e. S. cerevisiae). But what if a digital music synthesiser ‒ such as a synthetic yeast ‒ becomes available that can produce any music genre with the purest of sounds by the touch of a few buttons? Will synthesisers spoil the character of the music and lead to the loss of the much-lauded romantic mystique? Or will music synthesisers support composers and conductors to create novel compositions and even higher quality performances that will thrill audiences? This article explores these and other relevant questions in the context of winemaking and the role that yeast and its genomics play in the betterment of wine quality.

Preprint REVIEW | doi:10.20944/preprints202309.0846.v1

Rhabdomyosarcoma: Current Therapy, Challenges, and Future Approaches to Treatment Strategies

Ali Zarrabi, David Perrin, Mahboubeh Kavoosi, Micah Sommer, Serap Sezen, Parvaneh Mehrbod, Bhavya Bhushan, Filip Machaj, Jakub Rosik, Philip Kawalec, Saba Afifi, Seyed Mohammadreza Bolandi, Peyman Koleini, Mohsen Taheri, Tayyebeh Madrakian, Marek Jan Łos, Benjamin Lindsey, Nilufer Cakir, Atefeh Zarepour, Kiavash Hushmandi, Ali Fallah, Bahattin Koc, Mazaher Ahmadi, Susan E. Logue, Gorka Orive, Stevan Pecic, Joseph W. Gordon, Saeid Ghavami

Subject: Biology And Life Sciences, Life Sciences Keywords: Alveolar Rhabdomyosarcoma; Apoptosis; Autophagy; Unfolded Protein Response; Bioengineering; Tumor Stiffness

Online: 13 September 2023 (10:32:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0019.v2

MEMS Sensors Driven Scientific Process to Solve Acute Compartment Syndrome

Geraldine Merle, Alexandre Parent-Harvey, Edward Joseph Harvey

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Acute Compartment Syndrome; MEMS; Scientific process; biomarker; pressure; sensor; diagnosis; medical device; bioengineering; medicine

Online: 1 May 2023 (05:24:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0714.v1

Towards a Biomanufactory on Mars

Aaron Berliner, Jacob M. Hilzinger, Anthony J. Abel, Matthew McNulty, George Makrygiorgos, Nils J.H. Averesch, Soumyajit Sen Gupta, Alexander Benvenuti, Daniel Caddell, Stefano Cestellos-Blanco, Anna Doloman, Skyler Friedline, Desiree Ho, Wenyu Gu, Avery Hill, Paul Kusuma, Isaac Lipsky, Mia Mirkovic, Jorge Meraz, Vince Pane, Kyle B. Sander, Fengzhe Shi, Jeffrey M. Skerker, Alexander Styer, Kyle Valgardson, Kelly Wetmore, Sung-Geun Woo, Yongao Xiong, Kevin Yates, Cindy Zhang, Shuyang Zhen, Bruce Bugbee, Devin Coleman-Derr, Ali Mesbah, Somen Nandi, Robert W. Waymouth, Peidong Yang, Craig S. Criddle, Karen A. McDonald, Amor A. Menezes, Lance C. Seefeldt, Douglas S. Clark, Adam P. Arkin

Subject: Engineering, Automotive Engineering Keywords: space systems bioengineering; human exploration; mars; in situ resource utilization; life support systems; biomanufacturing

Online: 29 December 2020 (07:57:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1012.v1

Bone Regeneration with Stem Cells from Dental Pulp in a Rat Experimental Model

Haifa Hamad-Alrashid, Sandra Muntión, Fermín Sánchez-Guijo, Javier Borrajo-Sánchez, Felipe Parreño-Manchado, M. Begoña García-Cenador, F. Javier García-Criado

Subject: Chemistry And Materials Science, Biomaterials Keywords: DPSC; biomaterials; bone defect; osteogenesis; bone regeneration; angiogenesis; bioengineering; dental pulp; stem cells; bone graft

Online: 18 March 2024 (10:24:20 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202008.0574.v2

An Engineering Theory of Evolution

Simeon Castle, Claire Grierson, Thomas Gorochowski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: evolution; evotype; engineering theory; genotype-phenotype maps; directed evolution; selection; synthetic biology; bioengineering; evolvability; self-adaptive systems

Online: 9 December 2020 (10:51:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0363.v1

Extension of Equivalent System Mass for Human Exploration Missions on Mars

Aaron Berliner, George Makrygiorgos, Avery Hill

Subject: Engineering, Automotive Engineering Keywords: Space Systems Bioengineering; Equivalent System Mass; ESM; Environmental Control and Life Support Systems; ECLSS; Space Logistics; Uncertainty; Risk

Online: 18 January 2021 (17:39:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0058.v1

Towards Engineering Biosystems with Emergent Collective Functions

Thomas E. Gorochowski, Sabine Hauert, Jan-Ulrich Kreft, Lucia Marucci, Namid R. Stillman, T-Y. Dora Tang, Lucia Bandiera, Vittorio Bartoli, Daniel O. R. Dixon, Alex J. H. Fedorec, Harold Fellermann, Alexander G. Fletcher, Tim Foster, Luca Giuggioli, Antoni Matyjaszkiewicz, Scott McCormick, Sandra Montes Olivas, Jonathan Naylor, Ana Rubio Denniss, Daniel Ward

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: synthetic biology; multi-agent modelling; individual-based modelling; agent-based modelling; systems biology; emergence; multi-scale; bioengineering; consortia; collectives

Online: 5 May 2020 (03:45:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0401.v2

Space Bioprocess Engineering on the Horizon

Aaron Berliner, Isaac Lipsky, Davian Ho, Jacob Hilzinger, Gretchen Vengerova, George Makrygiorgos, Matthew McNulty, Kevin Yates, Nils Averesch, Charles Cockell, Tyler Wallentine, Lance Seefeldt, Craig Criddle, Somen Nandi, Karen McDonald, Amor Menezes, Ali Mesbah, Adam Arkin

Subject: Engineering, Bioengineering Keywords: space systems bioengineering; biomanufacturing; space bioprocess engineering; biotransformation human exploration; in situ resource utilization; life support systems; biomanufacturing; space policy

Online: 27 December 2021 (15:48:53 CET)

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