Project logistics is one of the specific logistics operations. Compared to other logistics operations, it needs more efficient planning and engineering applications in each operational process. On the other hand, each project logistics operation can be defined as tailor-made operations, since it has no similarity with other operations. Consequently, each project logistics operation should be planned and carried out according to its own conditions and parameters. This study focuses on the simulation of project logistics operations under the light of computerized applications from start to finish of the logistics operation. In this study, transportation operations of 600 tons of autoclave from the Petkim port to the Gördes building site were selected as a case study.

This paper presents an investigation of the oxidation of Alloy X-750 containing 5% Fe in a simulated boiling water reactor (BWR) environment. To mimic the conditions in which the bare metal is exposed to the reactor water the samples were not pre-oxidized. The specimens were exposed for durations ranging from 2 to 840 hours, and the development of the oxide microstructure was mainly studied using electron microscopy. The results showed that the oxide scale consisted of blocky crystals of trevorite on top of a porous inner layer rich in Ni and Cr. After the longest exposure time, the trevorite crystals completely covered the specimen surface. The study further revealed that the speed at which the oxide grew and the metal dissolved both decreased with time. Additionally, the metal thinning process was found to be sub-parabolic. Given the significant variation in iron content in the X-750 specification, the influence of this element on the material's corrosion performance in BWR was examined by comparing the results from this investigation with those from previous work on material containing 8 wt% Fe. The study demonstrated that the oxide growth, metal dissolution and metal thinning were slower in the material with higher Fe content, indicating the importance of this element in limiting the degradation of Alloy X-750 in BWR environments.

In recent years, numerous research studies have shown the excellent characteristics of silk fibroin nanoparticles as a vehicle for drugs delivery and it is foreseeable that their production could reach industrial scale in the coming years. For this reason, it is essential to know all the parameters that affect the formation of nanoparticles in order to standardize the process. Several studies have stated that the process used for sericin removal (degumming) from silk cocoons has a strong impact in the silk fibroin integrity and their mechanical properties after processing it into biomaterials. In this work, silk cocoons were degummed following four standard methods: autoclaving, short alkaline (Na2CO3) boiling, long alkaline (Na2CO3) boiling and ultrasounds. The resultant silk fibroin fibers were dissolved in the ionic liquid 1-ethyl-3-methylimidazolium acetate and used for nanoparticle synthesis by rapid desolvation in polar organic solvents. The relative efficiencies of the degumming processes and the integrity of the resulting fibroin fibers obtained were analyzed by weight loss, optical microscopy, thermogravimetric analysis, infrared spectroscopy and SDS-PAGE. Particle sizes and morphology were analyzed by Dynamic Light Scattering and Field Emission Scanning Electronic Microscopy. The results showed that the different treatments had a remarkable impact on the integrity of the silk fibroin chains, as confirmed by gel electrophoresis which can be correlated with particle mean size and size distribution changes. The study confirm that all the parameters of the process must be controlled in order to reach an optimum reproducibility of the nanoparticle production.

Almond is worldwide consumed and renowned as a valuable healthy food. In spite of this, it is also a potent source of allergenic proteins able to trigger several mild to life-threatening immunoreactions. Food processing proved to alter biochemical characteristics of proteins, thus affecting the respective allergenicity. In this paper we investigated the effect of autoclaving, preceded or not by a hydration step, on the biochemical and immunological properties of almond proteins. Any variation in the stability and immunoreactivity of almond proteins extracted from the treated materials, were evaluated by total protein quantification, ELISA assay and protein profiling by electrophoresis-based separation (SDS-PAGE). The autoclaving alone was found to weakly affect almond proteins stability, despite what observed for the combination of hydration and autoclaving, which resulted in a loss of approximately 70% of total protein content compared to untreated sample, and in a final negligible immunoreactivity, as well. The final SDS-PAGE protein pattern recorded for almonds hydrated and autoclaved disclosed significant changes. In addition, the same samples were further submitted to in vitro simulated gastro-duodenal (GI) digestion to evaluate potential changes induced by these processing on allergens digestibility. Digestion products were identified by HPLC-HRMS/MS analysis followed by software-based data mining, and complementary information were provided by analyzing the proteolytic fragments lower that 6 kDa in size. The autoclave based treatment was found not to alter the allergens digestibility, whereas an increased susceptibility to proteolytic action of digestive enzymes was observed in almonds subjected to the combination of prehydration and autoclaving. Finally, the residual immunoreactivity of the GI resistant peptides was investigated in-silico by bioinformatic tools, confirming that by following both approaches, no epitopes survived the almond digestion, thus demonstrating the potential effectiveness of these treatments to reduce almond allergenicity.