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The Polymer-Based Technology in the Endovascular Treatment of Abdominal Aortic Aneurysms

Gianmarco de Donato, Edoardo Pasqui, Claudia Panzano, Brenda Brancaccio, Gaia Grottola, Giuseppe Galzerano, Domenico Benevento, Giancarlo Palasciano

Subject: Medicine And Pharmacology, Surgery Keywords: Endovascular Aneurysm Repair; EVAR; Aortic Aneurysm; PEG; polymer; Vascular Surgery; aortic endograft.

Online: 24 February 2021 (10:00:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2134.v1

Role of Matrix Metalloproteinases in Thoracic Aortic disease: Are they indicators for the pathogenesis of dissections?

Marc Irqsusi, Lan Anh Dong, Fiora Rodepeter, Rabia Ramzan, Ildar Talipov, Tamer Ghazy, Madeline Günther, Sebastian Vogt, Ardawan Julian Rastan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Matrixmetalloprotease; Aortic Aneurysm; Aortic Dissection; Pathogenesis

Online: 30 January 2024 (15:07:23 CET)

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Pathogenesis of aortic aneurysm and dissection continues to be under discussion. Extracellular matrix (ECM) remodeling processes in the aortic wall are hypothesized to be involved in the development of the disorders. Therefore, in a histological study, we investigated the expression of metalloproteases 1 and 9 (MMP1 and MMP9) and their inhibitors (TIMP 1 and TIMP 2) in cardiac surgery patients. In parallel, we studied the aortic roots by echocardiography. Clinical reports of 111 patients (30 women and 81 men) who suffered from aortic aneurysms and an aortic dissection were evaluated and studied by transesophageal echocardiography. Seven patients, who had coronary heart disease served as „healthy controls“ All patients were surgically operated in the period from 2007 to 2015. A tissue sample of the aortic biopsies was collected from each patient during surgery. Immunohistochemical staining was performed for MMP1, MMP9 and TIMP1, TIMP2 as well. Vascularization was monitored by an CD 31 antibody. In direct comparison, the expressions are not homogeneous. We found smallest changes in the intima area at all. An increase in MMP 1 and MMP 9 expression was detected in both media and adventitia in case of dissections. TIMP 1 and TIMP 2 distribution increases from the lumen of the vessel outward in the wall layers of the aorta. In case of arteriosclerotic changes, intima had a capillarization, but not in the media. Opposite pattern was found in the dissected aortas. Whereas the intima appears empty, vascularization was found in the media and adventitia layers, as well. There are differences in the vascularization between between the aneurysm and dissection and the different layers as well, respectively. A different remodeling process of the ECM in comparison of the vascular layers must be hypothesized. Reading the patterns of staining and with regard to the known inhibitory effect of MMP9 on ECM remodeling, but especially TIMP 2 on neoangiogenesis, a disturbed nutrition and a dysfunctional vasa vasorum remodeling must be assumed as cause of dissection.

Preprint REVIEW | doi:10.20944/preprints202310.0618.v1

Intracerebral Hemorrhage Caused by Rupture of A Traumatic Pseudoaneurysm of The Middle Meningeal Artery

Myoung Soo Kim, Younghwan Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: meningeal artery; aneurysm; trauma; cerebral hemorrhage

Online: 10 October 2023 (10:14:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1548.v1

Influence of Blood Rheology and Turbulence Models in the Numerical Simulation of Aneurysms

Alberto Brambila-Solórzano, Federico Méndez-Lavielle, Jorge Naude, Gregorio Josué Martínez-Sánchez, Benjamín Hernández, Azael García-Rebolledo, Carlos Escobar-del Pozo

Subject: Engineering, Bioengineering Keywords: Aneurysm; CFD; blood flow; turbulence model; rheology.

Online: 22 August 2023 (13:51:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1864.v1

Perspectives and Implications of Coanda Effect in Aneurysms

Vicentiu Mircea Saceleanu, Razvan-Adrian Covache-Busuioc, Luca Andrei Glavan, Antonio Daniel Corlatescu, Alexandru Vlad Ciurea

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Coanda Effect; aneurysm; hemodynamics; Willis Polygon; pathology

Online: 26 May 2023 (05:26:59 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.2077.v1

Impact of Various Non-contrast Enhanced MRA Techniques on Lumen Visibility in Vascular Flow Models with Surpass Evolve Flow Diverter

Yigit Ozpeynirci, Margarita Gorodezky, Augusto Fava Sanches, Ana Beatriz Solana, Thomas Liebig

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: silent MRA; deep learning; flow diverter; intracranial aneurysm

Online: 31 January 2024 (01:46:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1260.v1

Development and Initial Characterisation of a Localised Elastin Degradation Ex Vivo Porcine Aortic Aneurysm Model

Matthew Laffey, Brooke Tornifoglio, Caitríona Lally

Subject: Engineering, Bioengineering Keywords: aortic aneurysm model; elastin; aorta compliance; aortic biomechanics

Online: 19 July 2023 (10:46:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1811.v1

Aortic Dilatation on the Edge of Dissection – Do We Operate Too Late? The Ratio between Ascending and Descending Aorta DiameteR (RADAR)

Nerea Lopez Perez, Philippe Reymond, Mustafa Cikirikcioglu, Mathieu Van Steenberghe, Tornike Sologashvili, Nicolas Murith, Thomas Perneger, Christoph Huber

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cardiac surgery; ascending aorta dissection, ascending aorta aneurysm

Online: 25 May 2023 (13:00:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0649.v1

Evidence of Global Warming: A Meta-Analysis of Temperature Management in Aortic Arch Surgery

Florian Huber, Bruno Schachner, Jessica Zofia Gottsberger, Peter Benedikt, Andreas Florian Zierer

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: hypothermia; hypothermic circulatory arrest,; aortic surgery; aortic aneurysm

Online: 20 April 2023 (10:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1406.v1

Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study

Malik Galijasevic, Ruth Steiger, Stephanie Alice Treichl, Wing Man Ho, Stephanie Mangesius, Valentin Ladenhauf, Johannes Deeg, Leonhard Gruber, Miar Ouaret, Milovan Regodic, Lukas Lenhart, Bettina Pfausler, Astrid Ellen Grams, Ondra Petr, Claudius Thomé, Elke Ruth Gizewski

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: subarachnoidal hemorrhage, brain aneurysm, phosphorous spectroscopy, vasospasm, delayed ischemia

Online: 26 February 2024 (09:42:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1632.v1

Determination of Significant 3D Hemodynamic Features for Post-Embolization Recanalization in Cerebral Aneurysms through Explainable Artificial Intelligence

Jing Liao, Kouichi Misaki, Mitsutoshi Nakada, Tekehiro Uno, Jiro Sakamoto

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: CFD; DNN; XAI; PointNet; flow pattern; cerebral aneurysm; recanalization

Online: 26 September 2023 (03:05:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0253.v1

Type I interferon receptor subunit 1 deletion attenuates experimental abdominal aortic aneurysm formation

Takahiro Shoji, Jia Guo, Yingbin Ge, Yankui Li, Gang Li, Toru Ikezoe, Wei Wang, Xiaoya Zheng, Sihai Zhao, Naoki Fujimura, Jianhua Huang, Baohui Xu, Ronald L. Dalman

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Abdominal aortic aneurysm; Type I interferon receptor, Leukocytes; Angiogenesis

Online: 19 September 2022 (02:08:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0636.v1

Risk Factors for Abdominal Aortic Aneurysm in Population-Based Studies: A Systematic Review and Meta-Analysis

Emma Altobelli, Leonardo Rapacchietta, Valerio F. Profeta, Roberto Fagnano

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: abdominal aortic aneurysm, risk factors, observational studies, meta-analysis

Online: 26 October 2018 (15:28:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0209.v1

Focus on the Most Common Paucisymptomatic Vasculopathic Population, from Diagnosis to Secondary Prevention of Complications

Eugenio Martelli, Iolanda Enea, Matilde Zamboni, Massimo Federici, Umberto M. Bracale, Giuseppe Sangiorgi, Allegra R. Martelli, Teresa Messina, Alberto M. Settembrini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: diagnosis; secondary prevention; complications; abdominal aortic aneurysm; carotid stenosis; lower extremity arterial disease; popliteal artery aneurysm; renal artery stenosis; subclavian artery stenosis

Online: 4 May 2023 (07:21:59 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1336.v1

Missense Variants in COL4A1/2 Are Associated with Cerebral Aneurysms: A Case Report and Literature Review

Masahiro Uemura, Natsuki Tanaka, Shoichiro Ando, Takehiko Yanagihara, Osamu Onodera

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: COL4A1; COL4A2; cerebral aneurysm; small vessel disease; large vessel abnormality

Online: 18 December 2023 (12:50:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1083.v1

Prevalence of Genetic Variants and Deep Phenotyping of Patients with Thoracic Aortic Aneurysm and Dissection: A Cross-Sectional Single Centre Cohort Study

Adrian Mahlmann, Nesma Elzanaty, Mai Saleh, Marc Irqsusi, Ardawan Rastan, Jennifer Lynne Leip, Christian-Alexander Behrendt, Tamer Ghazy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: thoracic aortic disease; phenotype; genetic mutation; genetic variant; aneurysm; dissection

Online: 14 December 2023 (12:14:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0343.v1

The Correlation of Aortic Neck Angle and Length in Abdominal Aortic Aneurysm with Severe Neck Angulation for Prediction of Intraoperative Neck Complications and Postoperative Outcomes after Endovascular Aneurysm Repair

Khamin Chinsakchai, Thana Sirivech, Frans L Moll, Sasima Tongsai, Kiattisak Hongku

Subject: Public Health And Healthcare, Health Policy And Services Keywords: abdominal aortic aneurysm; severe neck angulation; aortic neck length; outcomes

Online: 4 August 2023 (03:16:36 CEST)

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Objectives: Endovascular aneurysm repair (EVAR) in hostile neck has been associated with adverse outcomes. We aimed to determine the association of infrarenal aortic neck angle and length and establish an optimal cutoff value to predict intraoperative neck complications and post-operative outcomes. Methods: This was a retrospective review of intact infrarenal abdominal aortic aneurysm (AAA) with severe neck angulation (> 60 degrees) who underwent EVAR from October 2010 to October 2018. Demographic data, aneurysm morphology, and operative details were collected. The ratio of neck angle and length was calculated the optimal cutoff value of the aortic neck angle-length index. Patients were classified into two groups using latent profile analysis. Intraoperative neck complications, adjunct neck procedures, and early and late outcomes were compared. Results: 115 patients were included. Group 1(G1), aortic neck angle-length index ≤ 4.8, had 95 patients and Group 2 (G2), aortic neck angle-length index > 4.8, had 20 patients. Demographic data and aneurysm morphology were not significantly different between groups except for neck length (P < 0.001). G2 had more intra-operative neck complications than G1 (21.1% vs 55%, P = 0.005). Adjunctive neck procedures were more common in G2 (18.9% vs 60%, P < 0.001). Thirty-day mortality rate was not statistically different. G1 patients had a 5-year proximal neck re-intervention free rate comparable to G2 patients (93.7%G1 vs 87.5%G2, P = 0.785). The 5-year overall survival rate was not statistically different (59.9%G1 vs 69.2%G2, P = 0.891). Conclusions: Patients with aortic neck angle-length index > 4.8 are at greater risk of intraoperative neck complications and adjunctive neck procedures than patients with an aortic neck angle-length index ≤ 4.8. The 5-year proximal neck re-intervention free rate and the 5-year survival rate were not statistically different. The aortic neck angle-length index is a reliable predictor of intra-operative neck complications during EVAR in AAA with severe neck angulation.

Preprint ARTICLE | doi:10.20944/preprints201812.0199.v1

Fluid-Structure Interaction in Abdominal Aortic Aneurysms: Effect of Haematocrit

Yorgos G. Stergiou, Athanasios G. Kanaris, Aikaterini A. Mouza, Spiros V. Paras

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Abdominal Aortic Aneurysm; FSI; CFD; haematocrit; pulsatile flow; non-Newtonian

Online: 17 December 2018 (15:50:54 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202401.1564.v1

A Novel Mathematical Approach with a Correlating Computational Framework for Precisifying Aneurysmal Therapeutics

Aadittya Deouskar, Dhawal Agrawal

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Abdominal aortic aneurysm; Mathematical Linear Regression; Computational Fluid Dynamics; Dynamical Systems

Online: 22 January 2024 (07:48:14 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202402.1701.v1

Inferior Wall Double False Aneurysm as a Late Presentation of Acute Myocardial Infarction

Aleksander Zelias, Pawel Czub, Krzysztof Wróbel, Dominka Dykla, Anna Skwarek, Iwona Chrzan, Maria Bober, Malgorzata Urbanczyk-Zawadzka, Pawel Banys, Joanna Petryka-Mazurkiewicz, Tomasz Kula, Ryszard Gajdosz, Jerzy Sadowski, Dariusz Dudek

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: left ventricular free wall rupture; false aneurysm; tamponade; acute myocardial infarction; complication

Online: 29 February 2024 (12:52:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1282.v1

Interventional Radiology for High-Flow Aneurysm of the Pancreaticoduodenal Arcades with Median Arcuate Ligament Syndrome: Review of 14 Patients

Valentin Siauve, Olivier Chevallier, Amin Mazit, Nicolas Falvo, Pierre-Olivier Comby, Romaric Loffroy

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Celiac trunk. High-flow aneurysm. Interventional radiology. Median arcuate ligament. Pancreaticoduodenal artery. Transcatheter arterial embolization.

Online: 19 June 2023 (04:13:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0346.v1

Predictors of 30-Day Postoperative Outcome after Elective Endovascular Abdominal Aortic Aneurysm Repair; a Tertiary Referral Center Experience

Maria P Ntalouka, Petroula Nana, Alexandros Brotis, Athanasios Chatzis, Maria Mermiri, Konstantinos Stamoulis, Metaxia Bareka, Athanasios Giannoukas, Miltiadis Matsagkas, Eleni Arnaoutoglou

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: abdominal aortic aneurysm; endovascular procedure; prognosis; complications, postoperative; acute kidney injury; biomarkers; myocardial infarction; arrhythmia; cerebrovascular accident

Online: 6 September 2023 (08:52:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0030.v1

The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A Preliminary Study

Calogera Pisano, Carmela RIta Balistreri, Sonia Terriaca, Maria Giovanna Scioli, Paolo Nardi, Augusto Orlandi, Giovanni Ruvolo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: ascending aorta aneurysm; bicuspid aorta valve; tricuspid aorta valve; ERG transcriptional factor pathway; TGF-β-SMAD, Notch, and NO pathways modulation.

Online: 2 August 2022 (03:43:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202111.0346.v1

Oxidative Stress Inside the Pathogenesis of Ascending Aorta Aneurysms: A Clearer Vision for Identifying Promising Biomarkers and Therapeutic Targets

Carmela Balistreri, Calogera Pisano, Giovanni Ruvolo

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Ascending aorta aneurysm (AsAA); reactive oxygen species (ROS); oxidative stress; onset and progression of sporadic AsAA; management of AsAA; biomarkers and targets

Online: 19 November 2021 (11:19:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0745.v1

Machine Learning-Based Pulse Wave Analysis for Early Detection of Abdominal Aortic Aneurysms Using In Silico Pulse Waves

Tianqi Wang, Weiwei Jin, Fuyou Liang, Jordi Alastruey

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: abdominal aortic aneurysm; pulse wave analysis; one-dimensional modelling; in silico pulse waves; machine learning; recurrent neural network; long short-term memory

Online: 30 March 2021 (14:05:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0400.v1

Effects of Pulsatile Flow Rate and Shunt Ratio in Bifurcated Distal Arteries on Hemodynamic Characteristics Involved in Two Patient-Specific Internal Carotid Artery Sidewall Aneurysms: A Numerical Study

Hang Yi, Mark Johnson, Luke C. Bramlage, Ludwig Bryan, Zifeng Yang

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Internal carotid artery sidewall aneurysm (ICASA); hemodynamic behaviors; computational fluid dynamics (CFD); pulsatile flow rate (PFR); bifurcated shunt ratio; wall shear stress (WSS); oscillatory shear index (OSI); time-averaged pressure (TAP)

Online: 30 May 2022 (11:38:31 CEST)

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