Search | Preprints.org

Working Paper REVIEW

Eye Movements Actively Reinstate Spatiotemporal Mnemonic Content

Jordana Wynn, Kelly Shen, Jennifer Ryan

Subject: Social Sciences, Cognitive Science Keywords: eyetracking, eye movements, gaze, memory, retrieval, vision, aging

Online: 20 May 2019 (12:25:44 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0510.v1

Effect of the Application of an Innovative Program on Prevention of Falls in Seniors

Zbigniew Borysiuk, Paweł Pakosz, Mariusz Konieczny, Krzysztof Kręcisz

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: limits of stability; coactivation; EMG signal; falls; aging

Online: 22 October 2018 (16:07:16 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202210.0248.v1

Resolving Darwin’s Dilemma over Natural Selection, Individual Benefit and Aging-on the Natural Selection of Organismal Aging

Richard Walker

Subject: Biology And Life Sciences, Aging Keywords: Trade-off of survival for reproduction; natural selection of aging; regulatory redundancy; aging’s individual benefit; regulatory molecular biology; Darwin’s dilemma; aging-reproduction trade-off; aging declines force of selection; master gene; holistic regulatory mechanism

Online: 18 October 2022 (04:36:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202404.1131.v1

The Effect of Ageing on Phase Transformations and Nanoindentation Behaviour in Ni-Rich NiTi Alloys

Jerzy Ratajski, Blażej Bałasz, Katarzyna Mydłowska, Mieczysław Pancielejko, Łukasz Szparaga

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: NiTi; phase transformation; additive manufacturing; SLM; solution annealing; aging

Online: 17 April 2024 (11:46:51 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0862.v1

Nutrient Intake and its Association with Appendicular Total Lean Mass, Function and Strength in Older Adults: A Population-Based Study

Miguel Germán Borda, Jessica Samuelsson, Tommy Cederholm, Jonathan Patricio Baldera, Mario Ulises Perez-Zepeda, George E. Barreto, Anna Zettergren, Silke Kern, Rydén Lina, Mariana Gonzalez-Lara, Salomón Salazar-Londoño, Gustavo Duque, Ingmar Skoog, Dag Aarsland

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Sarcopenia; Body Composition; Aging; Diet; Walking Speed; Muscle Strength

Online: 11 January 2024 (10:21:38 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0305.v1

The Effect of Supraharmonic Distortion in MV and LV AC Grids and Derived Limits

Andrea Mariscotti, Alessandro Mingotti

Subject: Engineering, Electrical And Electronic Engineering Keywords: Accuracy; Aging; Distortion; Disturbance; Power losses; Power quality; Supraharmonics

Online: 4 January 2024 (03:22:08 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.1951.v1

Association between Donor Age and Osteogenic Potential of Human Adipose Stem Cells in Bone Tissue Engineering

Md Abdus Sattar, Lara F. Lingens, Vincent G.J. Guillaume, Rebekka Goetzl, Justus P. Beier, Tim Ruhl

Subject: Biology And Life Sciences, Life Sciences Keywords: ASC; osteogenic potential; osteoblast; aging; regenerative medicine; tissue engineering

Online: 28 December 2023 (02:07:28 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.1415.v1

The Importance of Complement-Mediated Immune Signaling in Alzheimer’s Disease Pathogenesis

André Felipe Batista, Khyrul Anam Khan, Maria-Tzousi Papavergi, Cynthia Ann Lemere

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: complement system; neurodegeneration; Alzheimer’s disease; neuroinflammation; aging; brain development

Online: 19 December 2023 (08:46:04 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1196.v1

Effect of Accelerated Aging Tests in Salt Spray of Single Lap Friction Stir Welded Joints between S355-J0 Steel – AA5083 Aluminum Alloy. – Part 1 – Mechanical Tests

Borsellino Chiara, Federica Favaloro, Guido Di Bella

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: joining; FSW; shipbuilding; aluminum; steel; aging tests; salt spay

Online: 15 December 2023 (18:56:57 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0189.v1

Nutritional Status and Physical Activity are Associated with Cognitive Function in Chinese Community-Dwelling Older Adults: the Role of Happiness

Jianghong Liu, Michael Pan, McKenna Sun, Haoer Shi, Rui Feng

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cognitive decline; physical activity; nutritional status; happiness; aging; diet

Online: 5 December 2023 (04:43:05 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202311.0442.v1

Microbial, Physicochemical Profile and Sensory Perception of Dry Aged Beef Quality and Safety: A Portuguese Preliminary Contribution for the Dry Ageing Process Validation

Ana Ribeiro, Irene Oliveira, Kamila Soares, Filipe Silva, Paula Teixeira, Cristina Saraiva

Subject: Biology And Life Sciences, Food Science And Technology Keywords: dry aged beef; aging process; microbiological profile; sensorial perception

Online: 7 November 2023 (11:06:34 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.1932.v1

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Jawad Nadeem, Amna Parveen, Sun Yeou Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Anti-aging, DNA damage response, senescence-associated secretory phenotype

Online: 28 September 2023 (04:56:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.2034.v1

The Supplementation of Sechium edule var. Nigrum Spinosum (Chayote) Promotes Nrf2-Mediated Antioxidant Protection in Older Adults with Metabolic Syndrome

Graciela Gavia-García, David Hernández-Álvarez, Taide Laurita Arista-Ugalde, Itzen Aguiñiga-Sánchez, Edelmiro Santiago-Osorio, Víctor Manuel Mendoza-Núñez, Juana Rosado-Pérez

Subject: Biology And Life Sciences, Aging Keywords: Sechium edule; metabolic syndrome; antioxidants; markers inflammatory; aging; RNAm

Online: 30 August 2023 (05:16:45 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1309.v1

Healthy Aging: Impact of Social Interaction on Psychological Well-Being in Older Adults— Longitudinal Study

Erika Ruperti-Lucero, Caridad López-Granero, Angel Barrasa

Subject: Social Sciences, Psychology Keywords: healthy aging; group dynamics; psychological well-being; older adult

Online: 18 August 2023 (09:18:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1138.v1

Neodymium Nitrate Improves the Germination of Aged Wheat Seeds by Increasing Soluble Substances and Activating Antioxidative and Metabolic Enzymes in Seeds

Genhai Hu, Xiuren Zhou, Qidi Zhu, Maoni Chao, Yuanzhi Fu, Haiyan Hu

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Neodymium; aging seed; germination; wheat; biochemical substance; enzyme activity

Online: 16 August 2023 (09:36:24 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1322.v1

Age and Task Modulate Olfactory Sensitivity in the Florida Carpenter Ant Camponotus floridanus

Stephen T Ferguson, Isaac Bakis, Nicholas D Edwards, Laurence J Zwiebel

Subject: Biology And Life Sciences, Insect Science Keywords: hymenoptera; olfaction; odor coding; task allocation; age polyethism; aging

Online: 19 July 2023 (10:03:17 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202306.1948.v1

The Reduction of Mitochondrial Membrane Potential in Aging: The Role of the Mitochondria Permeability Transition Pore

Hagai Rottenberg

Subject: Biology And Life Sciences, Aging Keywords: Aging, mitochondria, membrane potential, permeability transition pore, C. elegans

Online: 28 June 2023 (07:06:20 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1701.v1

Evaluating Sarcopenia Using Bioelectrical Impedance Vector Analysis and Phase Angle

Saizhao Tang, Fang Lin Jiang, Seon-Ho Eom, Jae-Young Lee, Ji Heon Chae, Chul-Hyun Kim

Subject: Public Health And Healthcare, Primary Health Care Keywords: bioelectrical impedance vector analysis; phase angle; aging; diagnosis; noninvasive

Online: 25 June 2023 (03:09:52 CEST)

Show abstract| Download PDF| Share

Sarcopenia becomes more common with age, being most prevalent among elderly individuals. According to the EWGSOP, muscle mass is one of the criteria for the evaluation of sarcopenia. The main methods for evaluating muscle mass are CT, MRI, and DXA, but these methods are difficult to apply in the field due to equipment costs, radioactivity, and lack of portability. BIVA and PhA are alternative approaches for assessing somatic cell mass and volume and do not require predictive equations. These variables are clinically relevant parameters that indicate cell health, especially cell membrane integrity and cell function. This study in sarcopenic and nonsarcopenic elderly volunteers aimed to determine the BIVA distribution pattern among individual sarcopenia patients; to evaluate the relationship between PhA and muscle strength, muscle quality, and physical function; and to find any correlates of PhA. The sample comprised 134 free-living elderly individuals of both sexes aged 69–91 years. Anthropometric parameters, grip strength, DXA findings, BIA results, and physical performance (the 6-meter walk test) were measured. Impedance vector distributions were evaluated in sarcopenia patients and healthy elderly individuals using BIVA. According to the AWGS criteria, sarcopenia was diagnosed according to DXA findings, grip strength and physical performance test results. Group differences were evaluated using the t test, Mann‒Whitney U test, and Hotelling's T2 test. Correlation analysis was performed to identify variables significantly associated with PhA. Linear regression analysis was performed to determine whether PhA was associated with muscle strength, muscle quality and physical function. BIVA detected a significant difference between the sarcopenia and non-sarcopenia groups (both sexes) due to higher R/H values and lower phase angles in a few individuals, whereas Xc/Ht values did not differ between the two groups. The sarcopenia group had a significantly lower PhA than the non-sarcopenia group among both males (p<0.01) and females (p<0.05). PhA was significantly correlated with age, ASM, HGS, and muscle quality in both sexes and significantly correlated with ASM/Ht2 and physical performance in males. PhA was a significant indicator of muscle strength in both males (β = 2.6; p<0.01) and females (β = 3.4; p<0.01), a significant indicator of muscle quality in both males (β = 0.07; p<0.05) and females (β = 0.17; p<0.01), and a significant indicator of physical performance in males (β = 0.3; p<0.01). BIVA can detect changes in muscle mass in individuals with sarcopenia and is a practical method for the assessment of sarcopenia in the field. PhA is a good indicator of muscle strength, muscle quality and physical performance (in males). These methods can help diagnose sarcopenia in elderly individuals with reduced mobility.

Preprint ARTICLE | doi:10.20944/preprints202306.1021.v1

piRNAs and miRNAs Can Bind to mRNA of KLOTHO and FGF23 Genes

Anatoliy Ivashchenko, Kyrmyzy Akhmetova, Murat Zhanuzakov, Togzhan Niyazova, Makpal Tauassarova, Aigul Akimniyazova, Aron Salimgerei

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: piRNA; miRNA; KLOTHO gene; FGF23 gene; anti-aging gene

Online: 14 June 2023 (09:00:00 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.2012.v1

Spatial Distribution Pattern and Evolution Characteristics of Elderly Population in Wuhan Based on Census Data

Fan Li, Jie Zhou, Wei Wei, Li Yin

Subject: Social Sciences, Urban Studies And Planning Keywords: spatial aging; elderly population; spatial distribution; spatial evolution; Wuhan

Online: 29 May 2023 (12:43:33 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1776.v1

Disruption of Mitochondrial Unfolded Protein Response Results in Telomere Shortening in Mouse Oocytes and Somatic Cells

Mauro Cozzolino, Yagmur Ergun, Emma Ristori, Akanksha Garg, Gizem Imamoglu, Emre Seli

Subject: Biology And Life Sciences, Aging Keywords: Telomere length; aging; Clpp; mitochondrial dysfunction; unfolded protein response

Online: 25 May 2023 (08:50:49 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1638.v1

Population Aging and Household Tourism Consumption——An Empirical Study Based on China Family Panel Studies (CFPS) Data

Xing Cai, Yinhe Zhang

Subject: Social Sciences, Tourism, Leisure, Sport And Hospitality Keywords: population aging; household tourism consumption; intergenerational care; Internet use

Online: 23 May 2023 (10:26:41 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202305.0598.v1

Aging Disrupts Circadian Rhythms in Mouse Liver Mitochondria

Wei Xu, Xiaodong Li

Subject: Biology And Life Sciences, Aging Keywords: circadian rhythms; aging; suprachiasmatic nucleus; peripheral clock; inflammatory response

Online: 9 May 2023 (08:19:43 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.0538.v1

Genetic Targeting of the dTORC1 Inhibitor, dSAMTOR, during Drosophila Aging: A Tissue-specific Pathology

Stamatia A. Katarachia, Sophia P. Markaki, Athanassios D. Velentzas, Dimitrios J. Stravopodis

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; Betaine; dBHMT; Drosophila; dSAMTOR; dTORC1; Kinase; Methionine; SAM

Online: 8 May 2023 (12:06:37 CEST)

Show abstract| Download PDF| Supplementary Files| Share

mTORC1 regulates mammalian cell metabolism and growth, in response to diverse environmental stimuli. Nutrient signals control the localization of mTORC1 onto lysosome-surface scaffolds that are critically implicated in its amino acid-dependent activation. Arginine, Leucine and S-Adenosyl-Methionine (SAM) can serve as major mTORC1-signaling activators, with SAM binding to SAMTOR (SAM + TOR), a fundamental SAM sensor, abolishing protein’s (SAMTOR’s) inhibitory action(s) against mTORC1, thereby releasing its (mTORC1) kinase activity. Given the lack of knowledge regarding the role of SAMTOR in invertebrates, we have, in silico, identified the Drosophila SAMTOR homologue (dSAMTOR) and have, herein, genetically targeted it, through utilization of the GAL4/UAS transgenic tool. Survival profiles and negative geotaxis patterns were examined both in control and dSAMTOR-downregulated adult flies, during aging. One of the two gene-targeted schemes resulted in lethal phenotypes, whereas the other one caused rather moderate pathologies in most tissues. Screening of head-specific kinase activities, via PamGene technology application, unveiled the significant upregulation of several kinases, including the dTORC1 characteristic substrate, dp70S6K, in dSAMTOR-downregulated flies, thus strongly supporting the inhibitory dSAMTOR function(s) upon dTORC1/dp70S6K signaling axis in Drosophila-brain settings. Importantly, genetic targeting of the Drosophila BHMT -bioinformatics- counterpart (dBHMT), an enzyme that catabolizes Betaine to produce Methionine (the SAM precursor), led to severe compromises in fly longevities, with glia-, motor neuron- and muscle-specific dBHMT downregulations exhibiting the strongest effects. Abnormalities in wing-vein architectures were also detected in dBHMT-targeted flies, thereby justifying their notably reduced negative geotaxis capacities, herein, observed, mainly in the brain-(mid)gut axis. In vivo adult-fly exposure to clinically relevant doses of Methionine revealed the mechanistic synergism of decreased dSAMTOR and increased Methionine levels in pathogenic longevity, thus rendering (d)SAMTOR an important component in Methionine-associated disorders, including Homocystinuria(s).

Preprint ARTICLE | doi:10.20944/preprints202304.0394.v1

Performance of Thermal-Oxidative Aging on the Structure and Properties of Ethylene Propylene Diene Monomer (EPDM) Vulcanizates

Hu Quanchao, Chen Qiang, Song Peiru, Gong Xingyu, Chen Junyi, Zhao Yongxian

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: EPDM vulcanizates; thermal-oxidative aging; thermal decomposition kinetics; antioxidant

Online: 17 April 2023 (04:07:38 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0130.v1

The Real Cause of Differential Aging in the Twin “paradox”

Gordon Liu

Subject: Physical Sciences, Theoretical Physics Keywords: Twin paradox; Relativity; Space-time; Time dilation; Differential aging

Online: 9 February 2022 (10:20:33 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0120.v1

Metabolomic Profiles of Mice Tissues Reveals an Interplay Between Aging and Energy Metabolism

Qishun Zhou, Jakob Kerbl-Knapp, Fangrong Zhang, Melanie Korbelius, Katharina Barbara Kuentzel, Nemanja Vujic, Alena Akhmetshina, Gerd Hörl, Margret Paar, Ernst Steyrer, Dagmar Kratky, Tobias Madl

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: aging; NMR spectroscopy; mice; energy metabolism; fat; intestine; metabolomics

Online: 8 December 2021 (12:03:07 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202111.0458.v1

Age-Dependent Decline of NAD+ - Universal Truth or Confounded Consensus?

Augusto Peluso, Mads Vargas Damgaard, Marcelo Alves Mori, Jonas Thue Treebak

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: NAD+; aging; yeast; C. elegans; mouse; rat; monkey; human

Online: 24 November 2021 (13:10:22 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202107.0158.v1

Maria Casagrande, Francesca Agostini, Francesca Favieri, Giuseppe Forte, Jasmine Giovannoli, Angela Guarino, Andrea Marotta, Fabrizio Doricchi, Diana Martella

Subject: Social Sciences, Psychology Keywords: Attention; Attentional Networks; Alerting; Orienting; Executive Control; Aging; Lateralization

Online: 6 July 2021 (14:52:33 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202101.0262.v1

Tissue-Specific Knockdown of Genes of the Argonaute Family Modulates Lifespan and Radioresistance in Drosophila Melanogaster

Ekaterina N. Proshkina, Elena Yushkova, Liubov Koval, Nadezhda Zemskaya, Evgeniya Shchegoleva, Ilya Solovev, Daria Yakovleva, Natalya Minnikhanova, Natalya Ulyasheva, Mikhail Shaposhnikov, Alexey Moskalev

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: lifespan; aging; radioresistance; ionizing radiation; Agronaute; Piwi; Drosophila melanogaster

Online: 14 January 2021 (08:07:44 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0115.v1

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

Vanesa Izquierdo, Verónica Palomera-Ávalos, Mercè Pallàs, Christian Griñán-Ferré

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cognitive decline; epigenetics; HFD; aging; SAM0P8; m6A, multigenerational inheritance.

Online: 4 December 2020 (14:54:58 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202005.0388.v1

Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?

Kouminin Kanwore, Xiao-xiao Guo, Ayanlaja Abdulrahman Abiola, Piniel Alphayo Kambey, Adekunle Adebayo Oluwafemi, Dianshuai Gao

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GDNF; SOX1; CAFs; senescence; aging cell; methylation; tumour; glioma

Online: 24 May 2020 (16:53:56 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202005.0074.v1

The Effects of Age, Gender, and Control Device in a Virtual-Reality Driving Simulation

Wen-Te Chang

Subject: Arts And Humanities, Philosophy Keywords: VR; aging effect; gender difference; control device; wayfinding strategy

Online: 5 May 2020 (11:32:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202003.0082.v1

Recent Progressive Use of Advanced Atomic Force Microscopy in Polymer Science: A Review

Phuong Nguyen-Tri, Payman Ghassemin, Pascal Carriere, Aymen Amine Assadi, Dinh Duc Nguyen

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: ARM-IR; polymers; polymer blends; polymer aging; nanoscale characterization

Online: 5 March 2020 (04:03:23 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201904.0240.v1

Sarcopenia is Associated Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)

Miji Kim, Chang Won Won

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: sarcopenia; slow gait speed; cognitive impairment; older adult; aging

Online: 22 April 2019 (11:28:59 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0563.v1

Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from Drosophila melanogaster

Camille M. Champigny, Robert P.J. Cormier, Chloé J. Simard, Patrick-Denis St-Coeur, Samuel Fortin, Nicolas Pichaud

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: mitochondrial metabolism; aging; monoacylglyceride; polyunsaturated fatty acids; oxidative stress

Online: 24 October 2018 (09:40:31 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201803.0123.v1

Multi-Azimuth Failure Mechanisms in Phosphor-Coated White LEDs by Current Aging Stresses

Zhangbao Peng, Ziquan Guo, Tingzhu Wu, Peng Zhuang, Yuan Shi, Tien-Mo Shih, Yijun Lu, Hao-Chung Kuo, Zhong Chen

Subject: Engineering, Electrical And Electronic Engineering Keywords: light-emitting diodes; failure mechanisms; current-stress aging; reliability

Online: 15 March 2018 (16:32:48 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201802.0048.v1

Body Weight Loss, Tissue Wasting and Shortened Lifespan in Late Middle-aged Mice on Imbalanced Essential/Non-essential Amino Acids Diet

Giovanni Corsetti, Evasio Pasini, Claudia Romano, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Vincenzo Flati, Francesco S. Dioguardi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Aging, Nutrition, Diet, Muscle atrophy, Body wasting, Food choice

Online: 5 February 2018 (23:43:16 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1871.v1

A mHealth intervention to promote physical activity for healthy aging: Every Walk You Take citizen science project

Preet Naik, Dolores Álamo-Junquera, Laura Igual, Marc Serrajordi, Albert Perez, Carles Pericas, Maria-Constança Pagès, Tarun Reddy Katapally, Maria Grau

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Healthy Aging; Active Living; Physical activity; Smart City; Citizen Science

Online: 1 April 2024 (10:13:37 CEST)

Show abstract| Download PDF| Share

Physical inactivity, highly dependent on community and environmental conditions, is the fourth leading cause of death worldwide. The objective of Every Walk You Take initiative was to co-design and test a mHealth intervention prototype (mobile app) to promote active living, and to identify barriers and facilitators for active living in individuals older than 55 years. Community stakeholders that included citizen scientists, teachers, researchers, health professionals and policy makers, familiar with the social and economic burden of aging in developed societies, codesigned the prototype. The app functionalities included recommendations on healthy routes in the city (parks, pedestrian lanes and streets) according to environmental variables (air quality and climate) and personal preferences (route difficulty, distance and geolocalization); and the collection of ecological momentary assessments (pictures and voice notes) to identify the barriers and facilitators to perform the routes. The prototype was tested in a pilot study in two deprived neighbourhoods of Barcelona. A total of 21 citizen scientists [mean age=67 (standard deviation=7)], 86% of them female collected, during two 7-day cycles, 112 comments and 48 pictures describing the barriers and facilitators for active living. The negative impact of dirty or damaged roads on citizen scientists’ motivation to engage in physical activity was highly reported as a barrier indicating that city infrastructure directly influences the public's inclination towards adopting active lifestyles. However, citizen scientists highlighted murals and urban green spaces they encountered, which made their walks more enjoyable and stimulating, as facilitators for active living. Every Walk You Take initiative constitutes the foundation for the development of novel models of health surveillance to address gaps in the current research landscape of active living. Moreover, the increased health literacy of the individuals ensures that they are more conscious about the role of physical activity in healthy ageing.

Preprint ARTICLE | doi:10.20944/preprints202402.1624.v1

Advanced-Glycation End Products-Selective Probe Development

Heewon Cho, Na-Kyeong Hong, Insung Yong, Haw-Young Kwon, Nam-Young Kang, Larissa Miasiro Ciaramicoli, Pilnam Kim, Young-Tae Chang

Subject: Chemistry And Materials Science, Other Keywords: Advanced glycation products; fluorescence small molecule; Fluorescence library; Screening; Aging

Online: 28 February 2024 (10:42:58 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202402.1158.v1

Respiratory Syncytial Virus Vaccines: Analysis of the Pre-Marketing Clinical Trial for Immunogenicity in the Population over 50 Years of Age

Georgios Papazisis, Xanthippi Topalidou, Georgia Gioula, Pablo A. González, Susan M Bueno, Alexis M Kalergis

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: immunosenescence; inflammaging; vaccinology; respiratory syncytial virus; aging; elderly; clinical trials

Online: 20 February 2024 (14:30:28 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202402.0993.v1

In Vivo-Matured Oocyte Resists Post-ovulatory Aging through the Post-transcriptional Regulation in Pigs

Cheng-Lin Zhan, Dongjie Zhou, Ming-Hong Sun, Wen-Jie Jiang, Song-Hee Lee, Xiao-Han Li, Qin-Yue Lu, Ji-Dam Kim, Gyu-Hyun Lee, Jae-Min Sim, Hak-Jae Chung, Eun-Seok Cho, Soo-Jin Sa, Xiang-Shun Cui

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: post-ovulatory aging; oocyte quality; mitochondrial function; post-transcriptional regulation

Online: 19 February 2024 (16:01:18 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.0482.v1

Potential of Cochayuyo (Durvillaea incurvata) Extract Obtained by Ultrasound Assisted Extraction Against Aging Related Diseases.

Nicolás Muñoz-Molina, Javier Parada, Mario Simirgiotis, Romina Montecinos-González

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Durvillaea incurvata; aging; enzymes inhibition; Alzheimer's, diabetes; hypertension

Online: 7 December 2023 (07:12:27 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.1885.v1

Advancements in the Anti-aging Effects of Physical Activity: Bibliometric- and Meta-Analyses

Yerim Choi, Daekyoo Kim, Seung Kyum Kim

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: aging; physical activity; bibliometric analysis; meta-analysis; frailty; resistance training

Online: 30 October 2023 (10:26:44 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.1143.v1

Estimation of Threshold Age for Cerebral Decline Using Sigmoidal Growth Model in Cross-Sectional Imaging Study

Namhee Kim, Moonseong Heo, Roman Fleysher, Malka Z. Sears, Michael L. Lipton

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging; sigmoidal growth function; nonlinear regression; threshold estimation; fractional anisotropy

Online: 18 September 2023 (14:27:39 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202308.1583.v1

The Shortening of Leukocyte Telomere Length Contributes to Alzheimer’s Disease: Further Evidence from Late-Onset Familial and Sporadic Cases

Paolina Crocco, Francesco De Rango, Serena Dato, Rossella La Grotta, Raffaele Maletta, Amalia Cecilia Bruni, Giuseppe Passarino, Giuseppina Rose

Subject: Biology And Life Sciences, Aging Keywords: Telomere length; Telomeres; Alzheimer’s Disease; late-onset AD, Aging, Neurodegeneration

Online: 22 August 2023 (13:22:03 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0824.v1

A Biopsychosocial Model Predicting Myocardial Infarction

José M. Tomás, Amparo Oliver, Zaira Torres, Janhavi Parker, Elena Marques, Trinidad Sentandreu-Mañó

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: biopsychosocial approach; coronary artery disease; cardiovascular disease; SHARE survey; aging

Online: 10 August 2023 (08:14:46 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0306.v1

Vision impairments in young adults with Down syndrome

Yolanda Martin-Perez, Guadalupe Gonalez-Montero, Angel Luis Gutierrez-Hernandez, Vanesa Blázquez-Sánchez, Celia Sánchez-Ramos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aging; Down syndrome; quality of life; refractive error; visual impairments

Online: 3 August 2023 (10:27:55 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1589.v1

Replicative Senescence in Vascular Smooth Muscle Cells: PURPL and NEAT1 Long Non-Coding RNAs as New Senescence-Associated Biomarkers

Clara Rossi, Marco Venturin, Jakub Gubala, Angelisa Frasca, Alberto Corsini, Cristina Battaglia, Stefano Bellosta

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: aging; biomarkers; lncRNA; NEAT1; PURPL; RRAD; senescence; smooth muscle cells

Online: 24 July 2023 (10:02:09 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202307.1412.v1

Hydrogen Assisted Aging to Storage & Sealing Materials: A Comprehensive Review

A.K.M. Ahsanul Habib, Ahmed Nazmus Sakib, Zarin Tasnim Mona, Md Monjur Hossain Bhuiyan, Pejman Kazempoor, Zahed Siddique

Subject: Engineering, Chemical Engineering Keywords: hydrogen; aging; polymer; storage and sealing materials; sustainability; pipeline; leak

Online: 20 July 2023 (10:11:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

Show abstract| Download PDF| Share

Preprint BRIEF REPORT | doi:10.20944/preprints202307.1015.v1

Short-Term Effects of Dietary Protein Supplementation on Physical Recovery in Older Patients at Risk of Malnutrition during Inpatient Rehabilitation: A Randomized Controlled Trial

Barbara Strasser, Vincent Grote, Walter Bily, Helena Nics, Patricia Riedl, Ines Jira, Michael J. Fischer

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: aging; dietary protein; hand-grip strength; physical function; rehabilitation; sarcopenia

Online: 14 July 2023 (11:32:28 CEST)

Show abstract| Download PDF| Share

It is estimated that about 50% of geriatric rehabilitation patients suffer from sarcopenia. Thereby, malnutrition is frequently associated with sarcopenia and dietary intake is the main modifiable risk factor. During hospitalization, older adults are recommended to consume more dietary protein than the current recommended dietary allowance of 0.8 g/kg body weight per day to optimize the recovery of muscular strength and physical function. This prospective study examined the effect of a short-term protein supplementation with protein-enriched foods and drinks on hand-grip strength, nutritional status and physical function in older patients at risk of malnutrition during a three week inpatient orthopedic rehabilitation stay. The Mini Nutritional Assessment (MNA) was used to assess malnutrition. Patients with a MNA score ≤ 23.5 points were randomly assigned to an intervention group (goal: to consume 1.2–1.5 g protein/kg body weight per day) or a control group (standard care). Both groups carried out the same rehabilitation program. Physical recovery parameters were determined at admission and discharge. There was a trend for participants in the intervention group to consume more protein than the control group (P = 0.058): 95.3 (SD 13.2) g/day as compared to 77.2 (SD 24.2) g/day, which corresponds to a mean protein intake of 1.6 (SD 0.3) g/kg/day vs. 1.3 (SD 0.5) g/kg/day. Dietary protein supplementation increased body weight by an average of 0.9 (SD 1.1) kg and fat mass by an average of 0.9 (SD 1.2) kg as compared with baseline (P = 0.039 and P = 0.050, respectively). There was no significant change in hand-grip strength, body composition and physical function. In conclusion, a short-term intervention with protein-enriched foods and drinks enabled older patients at risk of malnutrition to increase their protein intake to levels that are higher than their required intake. In these older individuals with appropriate protein intake, dietary protein supplementation did not result in a greater improvement in physical recovery outcomes during short-term inpatient rehabilitation. The intervention improved dietary protein intake, but further research (e.g., a full-scale randomized controlled trial with sufficient power) is required to determine the effects on physical function outcomes.

Preprint REVIEW | doi:10.20944/preprints202306.1728.v1

Nicotinamide Riboside, a Promising Vitamin B₃ Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Andrei Biţă, Ion Romulus Scorei, Maria Viorica Ciocîlteu, Oana Elena Nicolaescu, Andreea Silvia Pîrvu, Ludovic Everard Bejenaru, Gabriela Rău, Cornelia Bejenaru, Antonia Radu, Johny Neamţu, George Dan Mogoşanu, Steven A. Benner

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: nicotinamide riboside; vitamin B3 derivative; efficacy; safety; healthy aging; longevity

Online: 25 June 2023 (10:43:10 CEST)

Show abstract| Download PDF| Share

NAD⁺ is known classically as a metabolite that participates in catabolic and anabolic pathways throughout the metabolism that is taught to students in introductory biochemistry courses. However, non-classical studies starting over a decade ago found that NAD⁺ is also involved in higher order functions, in part because of its involvement in the activation of SIRTs and the support of the mitochondrial unfolded protein response. Many studies since have suggested that NAD⁺ is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes, Further, healthy aging and longevity appear to be closely related to NAD⁺ and its related metabolites, including NAR and NMN. Together, these studies show that this system has value as a dietary supplement to improve general health overall, as well as mitigating specific disease conditions. Accordingly, many are now recommending the consumption of materials in this system as dietary supplements. Nicotinamide riboside (NAR) appears to have special value in this regard. It appears to be better tolerated than other molecules in this system, as well as better pharmacodynamics and greater potency. Unfortunately, NAR is a reactive molecule, often unstable during its manufacturing, transport, and storage. Indeed, HPLC analyses of many commercial samples of NAR shows that they contain substantial amounts of material that are not, in fact, NAR. In some of these commercial preparations, NAR is a minority component. Therefore, more stable derivatives of NAR that are easily converted upon consumption into NAR are therefore desired. Recently work related to prebiotic chemistry provided the borate derivative of NAR. NARB is considerably more stable than NAR itself. However, immediately upon consumption, the borate dissociates from NARB, and is lost in the body through dilution and binding to other species, notably carbohydrates such as fructose and glucose. The NAR left behind is expected to behave pharmacologically in ways identical to NAR itself. This review provides a comprehensive summary (through Q1 of 2023) of literature that makes the case for the consumption of NAR as a dietary supplement. It then summarizes the challenges of delivering quality NAR to consumers using standard synthesis, manufacture, shipping, and storage approaches. It concludes by outlining the advantages of NAR-borate in these processes.

Preprint REVIEW | doi:10.20944/preprints202302.0516.v1

The Confound of Hemodynamic Response Function Variability in Resting-State Functional MRI Studies

D Rangaprakash, Robert Barry, Gopikrishna Deshpande

Subject: Biology And Life Sciences, Biophysics Keywords: BOLD fMRI; HRF; resting state connectivity; aging; sex differences; confound

Online: 28 February 2023 (09:32:04 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202301.0374.v1

Very Low and High Levels of Vitamin D are Associated with Shorter Leukocyte Telomere Length in 148,321 UK Biobank Participants

Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. Pilling, George A. Kuchel, Richard Kremer, Gustavo Duque

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Telomerase; leukocyte telomere length; vitamin D; aging; serum levels; geroscience

Online: 22 January 2023 (03:36:34 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0153.v2

Trends in Excess Winter Mortality (EWM) From 1900/01 to 2019/20—Evidence for a Complex System of Multiple Long-Term Trends

Rodney P. Jones, Andrey Ponomarenko

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: winter mortality; trends; season; estimated influenza mortality; pandemic influenza; aging

Online: 25 February 2022 (14:24:30 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202111.0043.v1

Managing Skin Ageing as a Modifiable Disorder – The Clinical Application of Nourella® Dual Approach Comprising a Nano-encapsulated Retinoid, Retilex-A® and a Skin Proteoglycan Replacement Therapy, Vercilex®

Jan Wadstein, Israel Sánchez Alvarez, Erling Thom, Lidia Bernal López

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin Aging; Rejuvenation; Skin Cream; Retinoid formulation; RetileX-A; Vercilex

Online: 2 November 2021 (10:55:27 CET)

Show abstract| Download PDF| Share

Preprint HYPOTHESIS | doi:10.20944/preprints202108.0267.v1

From Oncological Paradigms to Non-Communicable Disease Pandemic. The Need of Recovery Human Biology Evolution

Elia Biganzoli, Romano Demicheli

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer dormancy; Low-grade chronic inflammation; Healthy aging; Physical exercise

Online: 11 August 2021 (17:57:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202102.0091.v1

Frailty as a Moderator of the Relationship Between Social Isolation and Health Outcomes in Community-Dwelling Older Adults

Fereshteh Mehrabi, François Béland

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Frailty; Social Isolation; Social Networks; Social Support; Social Participation; Aging

Online: 2 February 2021 (14:32:33 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202012.0683.v1

Effectiveness of tDCS to Improve Recognition and Reduce False Memories in Older Adults

Juan C Melendez, Encarnación Satorres, Alfonso Pitarque, Iraida Delhom, Elena Real, Joaquin Escudero

Subject: Social Sciences, Psychology Keywords: transcranial direct current stimulation; true recognition; false recognition; aging; experiment.

Online: 28 December 2020 (11:15:38 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202011.0019.v1

Semelparity and Reproductive Death in Caenorhabditis elegans

David Gems, Carina Kern, Joseph Nour, Marina Ezcurra

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: aging; biomass conversion; C. elegans; reproductive death; semelparity; senescent pathology

Online: 2 November 2020 (10:45:56 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202010.0572.v1

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

Young Eun Choi, Min Ji Song, Mari Hara, Kyoko Imanaka-Yoshida, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; collagen; extracellular matrix; fibroblast; skin; tenascin C; TGF-β

Online: 28 October 2020 (08:49:54 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint TECHNICAL NOTE | doi:10.20944/preprints202009.0168.v1

Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach

Md. Adnan Arefeen, Sumaiya Tabassum Nimi, M. Sohel Rahman, S. Hasan Arshad, John W. Holloway, Faisal I. Rezwan

Subject: Computer Science And Mathematics, Computer Science Keywords: lung function; epigenetic aging; machine learning; feature selection; hyperparamter tuning

Online: 8 September 2020 (03:15:28 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0173.v1

Effect of Retrogression Re-aging Treatment on Corrosion Behavior of 7055 Al-Zn-MG Alloy

Fuqiang Guo, Shuwei Duan, Dongting Wu, Kenji Matsuda, Tao Wang, Yong Zou

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Al-Zn-Mg alloy; Retrogression re-aging treatment; Corrosion; Electrochemistry

Online: 9 July 2020 (07:34:27 CEST)

Show abstract| Download PDF| Share

Preprint CONCEPT PAPER | doi:10.20944/preprints202004.0158.v1

How studies on inflamm-aging may help to understand and combat COVID-19 pandemic.

Gianluca Storci

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Covid-19; SARS-CoV-2; Inflamm-aging; mtDNA; Telomere; Inflammation

Online: 9 April 2020 (14:43:41 CEST)

Show abstract| Download PDF| Share

More than 1,000,000 confirmed cases of COVID-19 have been registered worldwide since the beginning of the pandemic in Wuhan on December 2019. The high mortality rate of COVID-19 is associated with age, gender and the presence of comorbidities. Biochemical data have shown that COVID-19 patients develop a local and systemic hyper-inflammatory response associated with poor outcome. Therefore, the understanding of the biological mechanisms underlying SARS-CoV-2-induced inflammation is a compelling need. Following this reasoning, here we will focus on the importance of the progressive age-related development of a pro-inflammatory state (aka inflamm-aging) in the understanding of the unbalanced inflammatory response against SARS-CoV-2 in aged people. In particular, we underpin the role of mitochondrial DNA and genomic DNA telomeric sequences in local and systemic mechanisms of inflammation. Indeed, the leakage of mtDNA out of its natural compartment (i.e. the mitochondrion), into the cytoplasm and in the extracellular environment is a powerful trigger of innate immunity and inflammation, as part of an evolutionary-conserved signaling mechanism of cellular damage (e.g. viral infection). High levels of circulating mtDNA are increased in aged people and set up as inflammatory markers of poor prognosis in intensive care unit patients. In turn, telomeric DNA, which can be released into the cytoplasm and in the extracellular environment upon cell damage, has been proven to exert potent anti-inflammatory activity. Since that aged people (particularly those affected by co-morbidity) are equipped with shortened telomeres, we posit that, in aged people affected by COVID-19 the release of mtDNA, coupled with insufficient telomeric DNA favors the onset of a detrimental inflammatory response. In this regard, we highlight that the mechanism of action of some currently used drugs, as well as potential new ones may be better understood under the light of the above-depicted theoretical framework thus explaining how studies on inflamm-aging may help to understand and combat COVID-19 pandemic.

Preprint ARTICLE | doi:10.20944/preprints201904.0163.v1

Butyl Rubber-Based Composite: Thermal Degradation and Prediction of Service Life Time

Phuong Nguyen-Tri, Ennouri Triki, Tuan Anh Nguyen

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymer aging; swelling behavior; protective glove materials; elastomers; composites; rubber

Online: 15 April 2019 (11:29:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201904.0120.v1

The Validity of a Mixed Reality-Based Automated Functional Mobility Assessment

Ruopeng Sun, Roberto G. Aldunate, Jacob J Sosnoff

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: mixed reality headset; mobility assessment; wearable sensor; fall risk; aging

Online: 10 April 2019 (08:33:16 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Working Paper ARTICLE

Dietary Diversity and Nutritional Adequacy Among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Naomi Cano-Ibáñez, Alfredo Gea, Miguel A. Martínez-González, Jordi Salas-Salvadó, Dolores Corella, M. Dolors Zomeño, Dora Romaguera, Jesús Vioque, Fernando Aros, Julia Wärnberg, J. Alfredo Martínez, Lluis Serra-Majem, Ramón Estruch, Francisco Tinahones, José Lapetra, Xavier Pintó, Josep A. Tur, Antonio García-Ríos, Blanca Riquelme-Gallego, Miguel Delgado-Rodríguez, Pilar Matía, Lidia Daimiel, Vicente Martín, Josep Vidal, Clotilde Vázquez, Emilio Ros, Pilar Buil-Cosiales, Andrés Díaz-López, Rebeca Fernández-Carrión, Montserrat Fitó, Jadwiga Konieczna, Leyre Notario-Barandiaran, Ángel M. Alonso-Gómez, Eugenio Contreras-Fernández, Itziar Abete, Almudena Sánchez-Villegas, Rosa Casas, Araceli Muñoz-Garach, José Manuel Santos-Lozano, Laura Gallardo-Alfaro, Josep Basora, Olga Portoles, Miguel Ángel Muñoz, Manuel Moñino, Salvador Miralles Gisbert, Anai Moreno Rodríguez, Miguel Ruiz-Canela, Antoni Palau Galindo, Karla Alejandra Pérez-Vega, Aurora Bueno-Cavanillas

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Dietary diversity; nutrient adequacy; metabolic syndrome; aging; PREDIMED-Plus study

Online: 18 March 2019 (09:25:48 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201901.0110.v1

Prediction Models to Control Aging Time in Red Wine

G Astray, JC Mejuto, V Martinez-Martinez, I Nevares, M Alamo-Sanza, Jesus Simal-Gandara

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Food authenticity; Toro appellation of origin; Prediction Models; Wine; Aging.

Online: 11 January 2019 (10:50:58 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201812.0359.v1

Mechanical Behavior of Inconel 625 at Elevated Temperatures

Mauro M. de Oliveira, Antônio A. Couto, Gisele F. C. Almeida, Danieli A. P. Reis, Nelson B. de Lima, Renato Baldan

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Inconel; high temperature; tensile test; creep; serrated; dynamic strain aging

Online: 31 December 2018 (09:41:56 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201709.0149.v1

Long Term Aging Treatment Impact on Ultralow Iron Alloy 625 Intergranular Corrosion Property

Zhi-yuan Zhu, Yi Sui, An-lun Dai, Yuan-fei Cai, Ling-li Xu, Ze-xin Wang, Hong-mei Chen, Xing-ming Shao, Wei Liu

Subject: Chemistry And Materials Science, Metals, Alloys And Metallurgy Keywords: Alloy 625; aging sensitization treatment; intergranular corrosion; ASTM G28A methods

Online: 29 September 2017 (04:13:44 CEST)

Show abstract| Download PDF| Share

This paper investigates the evolution of microstructures and precipitations of an ultra-low iron alloy 625 subjected to long term aging treatment by scanning electron microscope (SEM) and X-ray diffraction(XRD). Use ASTM G28A acid Fe3(SO4)2 erosion to represent intergranular corrosion weightlessness and corrosive morphology. The result shows that alloy at 750C by aging treatment for 40h, precipitated γ'' phase in the grain boundary. In high density area of γ'' phase, occurs γ'' phase to δ phase degeneration transformation by aging treatment for 200h and the needle-like δ phase becomes more with time prolonged. And γ'' phase degenerated to δ phase completely until treated for 1000h. The sample which has aging treatment tends to have intergranular corrosion and mainly because alloy element spreading leads to dilution area and grain boundary precipitated phase, plus interlaced δ phase’s dissolving, which makes sample grain particle fall off and this results in apparent weightlessness. The weightlessness rate(WLR) is related with precipitated volume score. With aging sensitization time change, can be described by Johnson-Mehl-Avrami equation, i.e.:

W L R = 44.32 [1 - exp (- \frac{t}{10.99})] + 44.62 [1 - exp (- \frac{t}{327.8})] + 1.267 (m m / a)

Preprint ARTICLE | doi:10.20944/preprints201610.0003.v1

2nd life batteries on a gas turbine power plant to provide area regulation services.

Lluc Canals Casals, Beatriz Amante García

Subject: Engineering, Energy And Fuel Technology Keywords: Aging model; Lithium ion batteries; Second life applications, Area regulation

Online: 3 October 2016 (16:33:54 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202310.0053.v1

On the Origin of Aging by Means of Natural Selection

Richard Francis Walker

Subject: Biology And Life Sciences, Aging Keywords: aging vs survival; DNA damage; double-stranded breaks; Gompertz-Makeham Law; developmental regulatory redundancy; tradeoffs vs emergent properties; fecundity; reproductive fitness; redundancy reliabiiity; programmed aging

Online: 2 October 2023 (08:08:57 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1802.v1

Aging Renewal Point Processes and Exchangeability of Event Times

Fabio Vanni, David Lambert

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: renewal processes; exchangeability; statistical aging; survival analysis; high frequency exchange rates

Online: 29 March 2024 (07:41:00 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1242.v1

Effects of Lignin on the Thermal and Morphological Properties and Damages Mechanisms after UV Irradiation of Polypropylene Biocomposites Reinforced with Flax and Pine Fibres: Acoustic Emission Analysis

Zouheyr Belouadah, Khaled Nasri, Lotfi Toubal

Subject: Engineering, Mechanical Engineering Keywords: biocomposites; UV aging; acoustic emission; damage mechanisms; environmental degradation; thermogravimetric analysis

Online: 20 March 2024 (17:03:54 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202403.1038.v1

Protocol for the Nutrition for Brain and Body Health Study: A Randomized Feasibility Trial

Rachel Silver, Suzannah Gerber, Sai Krupa Das, Savana Greene, Maria Carlota dao, John Sunwoo, Lisa Ceglia, Sadie Dix, Kathryn Barger, Maria Angeline Franceschini, Ronald Cohen, Susan Roberts

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: cognitive decline, aging, obesity, nutrition, clinical trial, protocol, Alzheimer's, neurodegenerative, food

Online: 18 March 2024 (12:12:31 CET)

Show abstract| Download PDF| Supplementary Files| Share

Older adults with obesity have an increased risk for cognitive decline and subsequent Alzheimer’s disease. Previous research has focused on the impact of individual nutrients and overall dietary patterns to improve cognitive function. The Brain and Body Health (BB-Health) study aims to demonstrate the feasibility of a multicomponent nutritional supplement (MCNS) and weight loss (WL) intervention for individuals with overweight and obesity who are not consuming a healthy diet. BB-Health is a parallel-group randomized placebo-controlled 2x2 factorial pilot trial comparing the MCNS, WL, and MCNS+WL with a Control group. Eligible participants are 55 to 85 years of age with a body mass index 27.0 to 39.9 kg/m2. Major exclusion criteria include type 2 diabetes, moderate or severe cognitive impairment, and self-reported healthy dietary pattern. The BB-Health feasibility trial is registered as NCT05542199 at clinicaltrials.gov. The BB-Health objectives are to report: 1) recruitment and enrollment, including pace and descriptive statistics of the study sample; 2) adherence to the administered interventions; 3) successful data collection and performance of outcome assessments, including evaluation of change in key outcomes over time that are powered for this pilot study; and 4) summary statistics on outcomes for use in planning a subsequent, larger trial. The outcomes of interest are age-sensitive cognitive assessments, cerebral hemodynamics, and related health parameters. All measurements are collected at baseline, 3-, 6-, and 12-month visits. If the BB-Health protocol demonstrates feasibility, the novel MCNS with and without a parallel WL intervention has potential to be administered in a confirmatory randomized trial to evaluate ability to prevent age-related cognitive decline and improve brain health. The BB-Health Feasibility Study could significantly contribute to our understanding of the influence of diet and weight management on cognitive health

Preprint ARTICLE | doi:10.20944/preprints202402.1647.v1

Study on the Mechanical and Aging Properties of an Antibacterial Composite Resin Loaded with Fluoride‐Doped Nano‐Zirconia Fillers

Liyuan Zheng, Yi Zhang, Yuming Bai, Qianju Wu

Subject: Public Health And Healthcare, Other Keywords: Composite resin; Nano-zirconia fillers; Fluoride-releasing; Antibacterial property; Aging test

Online: 29 February 2024 (08:09:49 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202401.0211.v1

Tobacco Smoking as an EDC in Aging

Ho-Sun Lee, Hyun-Kyung Na, Seong-Sil Chang, Soo-Young Kim, Chang Seong Kim, Yoonjeong Song, Mihi Yang

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: tobacco smoking; biological monitoring; adolescent; genetic polymorphism; addiction; mtDNA alteration; aging

Online: 4 January 2024 (03:43:27 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202309.1738.v1

Zebrafish as an Emerging Model for Sarcopenia: Considerations, Current Insights, and Future Directions

Santiago Callegari, Foad Mirzaei, Lila Agbaria, Sanobar Shariff, Burhan Kantawala, Desmond Moronge, Brian M. O. Ogendi

Subject: Biology And Life Sciences, Aging Keywords: Sarcopenia; Zebrafish; Age-related muscle deficits; Aging; Biomarkers; Electrical Impedance Myography

Online: 26 September 2023 (13:38:16 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0213.v1

Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Kumar Sandeep Singh, Kumar Sambamurti, Miguel A. Pappolla

Subject: Biology And Life Sciences, Aging Keywords: aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide

Online: 6 September 2023 (14:47:08 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.0090.v1

Nitric Oxide as a Determinant of Human Longevity and Health Span

Burkhard Poeggeler, Sandeep Kumar Singh, Kumar Sambamurti, Miguel A. Pappolla

Subject: Biology And Life Sciences, Aging Keywords: aging; amino acids; antioxidant; arginine; nitric oxide; oxidative stress; protein; peptide

Online: 1 September 2023 (16:25:31 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.1184.v1

Diagnosing Alzheimer's Disease Levels Using Machine Learning and MRI: A Novel Approach

Reza Bahadori, Ali Akbar Kiaei, Hourieh Malek Zadeh, Mahnaz Boush, Sadegh Abadijou, Danial Safaei, Amir Hossein Mehdikhani

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Alzheimer's disease; neurological illness; dementia; machine learning; Magnetic Resonance Im-aging

Online: 16 June 2023 (07:28:28 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0246.v1

On the Safety of Implanted Breast Prostheses in Accidental Impacts

Gerardus Janszen, Michela Arnoldi, Valeriano Vinci, Marco Klinger, Luca Di landro

Subject: Chemistry And Materials Science, Biomaterials Keywords: breast implants; silicone prosthesis aging; accidental impacts; crash test; compression tests

Online: 5 June 2023 (05:38:46 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.2235.v1

New Insights into the Enhancement Effect of Exogenous Calcium on Biochar Stability during Its Aging in Farmland Soil

Hongyan Nan, Yunqiu Jiang, Weiqi Zhou, Ling Zhao, Fan Yang

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: Biochar aging; Ca-rich biochar; Carbon stability; Farmland soil; Carbon sequestration

Online: 31 May 2023 (11:18:37 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202303.0088.v1

IoT-based Technologies for Addressing the Unique Healthcare Needs of the Elderly Population

Syed Adnan Ali, Rehan Khan

Subject: Computer Science And Mathematics, Information Systems Keywords: IoT; geriatric healthcare; IoMT; biomedical devices; telemedicine; remote monitoring; aging population

Online: 6 March 2023 (04:20:47 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202211.0255.v3

How Much of Aging Is Simply a Trash Collection Problem?

Michael Renteln

Subject: Biology And Life Sciences, Aging Keywords: Anti-aging therapy; lipofuscin; SENS; oncolytic vector; telomerase; TFEB; intracellular microbe

Online: 22 February 2023 (15:24:21 CET)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202301.0334.v1

Serotonin Impact on Lifespan Longevity in Marine Annelid D.gyrociliatus

Elizaveta Fofanova

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: serotonin; pcpa; cystamine; dinophilida; invertebate models; aging; maternal serotonin; lifespan longevity

Online: 18 January 2023 (10:22:43 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0364.v1

Efﬁcacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Sarang Oh, Jeehaeng Jeong, Xiangji Jin, Myeongju Kim, Shengdao Zheng, Tae-Hoo Yi

Subject: Medicine And Pharmacology, Dermatology Keywords: Phaseolus angularis seed extract (PASE); anti-aging; health skin, cosmetic products

Online: 20 December 2022 (09:03:36 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202212.0332.v1

Effect of Aging of Orthodontic Aligners in Different Storage Media on Force and Torque Generation: An in vitro Study

Tarek Elshazly, Diva Nang, Bijan Golkhani, Hanaa Elattar, Christoph Bourauel

Subject: Chemistry And Materials Science, Biomaterials Keywords: Biomechanics; Orthodontic force; Torque; Tooth Movement; Removable Thermoplastic Appliance; Aging; Aligners

Online: 19 December 2022 (09:10:51 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202208.0011.v1

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Olajuwon Okubena, Adaeze Adebesin, Adrian Omogbiya, Oluwafemi Oluwole, Rita Asomadu, Michael Afolabi, Samira Makanjuola, Louis Ajonuma, Adedoyin Dosunmu, Ololade Otitoloju, Solomon Umukoro

Subject: Biology And Life Sciences, Food Science And Technology Keywords: SBSJ; polyphenolic constituents; antioxidants; anti-inflammatory, chemoprevention; immunomodulation; anti-aging; adaptogen

Online: 1 August 2022 (08:06:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202205.0061.v1

Sustainable Transformation of Digital Health Services- A Stakeholder Exploratory Case Study

Siyu Zhou, Ziling Ni, Atsushi Ogihara, Xiaohe Wang

Subject: Public Health And Healthcare, Health Policy And Services Keywords: sustainability; digital transformation; suitable for aging; service ecological theory; health service

Online: 6 May 2022 (07:45:20 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202204.0055.v1

Activity-Dependent Induction of Younger Molecular, Cellular and Organism Phenotypes

Thomas Lissek

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cell; biology; aging; medicine; transcription; activity; neurons; brain; immune system; muscle

Online: 7 April 2022 (04:24:23 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0026.v2

Telomere Shortening linked to Disability and Mitochondrial DNA Copy Number in Patients with Relapsing-Remitting Multiple Sclerosis

José Alfonso Cruz-Ramos, Gabriela del Carmen López-Armas, Eduardo Ignacio Díaz-Barba, Mónica Navarro-Meza, Miguel Ángel Macías-Islas, Ana Miriam Saldaña-Cruz, Abraham Zepeda-Moreno, Héctor Raúl Pérez-Gómez, Alejandra Martínez-Hernández, Martha Eloísa Ramos-Márquez

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Leukocyte telomere length; Mitochondrial DNA; Relapsing- Remittent Multiple Sclerosis; Disability; Aging

Online: 7 December 2021 (12:35:12 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202107.0576.v1

Glassy Polymers – Diffusion, Sorption, Aging, and Applications

Raj Kumar Arya, Devyani Thapliyal, Jyoti Sharma, G. D. Verros

Subject: Engineering, Automotive Engineering Keywords: Glassy Polymers; Diffusion; Sorption; Physical Aging; Polymer Coatings; Gas Separation Membranes

Online: 26 July 2021 (13:52:57 CEST)

Show abstract| Download PDF| Share

Working Paper REVIEW

Appropriate Technologies to Accompany Sunscreens in the Battle Against Ultraviolet, Superoxide and Singlet Oxygen

Paolo Giacomoni

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Ultraviolet; superoxide; singlet Oxygen; cell blebbing; skin aging; peroxidative cascade; antioxidants

Online: 21 October 2020 (10:32:55 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0268.v1

Rapid Senectome and Alternative Splicing miRNAs Changes with the Relaxation Response: A One Year Follow-Up Study

Carlo Dal Lin, Mariela Marinova, Laura Brugnolo, Giorgio Rubino, Mario Plebani, Sabino Iliceto, Francesco Tona

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cardiovascular disease; inflammation; aging; senectome, telomerase; alternative splicing; relaxation response; microRNA

Online: 12 July 2020 (16:57:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201912.0338.v2

Effect of Artificial Aging Treatment and lubrication Modes on the Machinability of A356 Cast Alloys

Mohamed Amine Alliche, Abdelhakim Djebara, Yasser Zedan, Victor Songmene

Subject: Chemistry And Materials Science, Materials Science And Technology Keywords: aluminum alloys; artificial aging; drilling; surface quality; cutting fluid; burr formation

Online: 27 March 2020 (02:54:29 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201911.0190.v1

Epigenetic Signalling and RNA Regulation in Cardiovascular Diseases

Alessia Mongelli, Sandra Atlante, Tiziana Bacchetti, Fabio Martelli, Antonella Farsetti, Carlo Gaetano

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: epigenetics; nucleic acids; RNA; DNA; cardiovascular disease; chronic disease; aging, metabolism

Online: 16 November 2019 (00:59:04 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201810.0133.v2

Age- and Genotype-Specific Effects of the Angiotensin-Converting Enzyme Inhibitor Lisinopril on Mitochondrial and Metabolic Parameters in Drosophila melanogaster

Karis A. Ederer, Kelly Jin, Sarah Bouslog, Lu Wang, Greg S. Gorman, Glenn C. Rowe, Peter Abadir, Daniel Raftery, Douglas Moellering, Daniel Promislow, Patricia Jumbo-Lucioni, Maria De Luca

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: aging; angiotensin-converting enzyme inhibitors; nutrient metabolism; genetic background; nutritional stress

Online: 29 October 2018 (10:33:59 CET)

Show abstract| Download PDF| Share

Search Results

319 articles found