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Preprint ARTICLE | doi:10.20944/preprints202001.0244.v1

Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice

Dolors Puigoriol-Illamola, Mirna Martínez-Damas, Christian Griñán-Ferré, Mercè Pallàs

Subject: Life Sciences, Molecular Biology Keywords: Stress; epigenetics; senescence; cognition; age-related cognitive decline; Alzheimer’s disease; SAMP8; SAMR1; oxidative stress; inflammation; autophagy

Online: 21 January 2020 (11:44:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0122.v1

Spatial and Age Related Effects on Phytochemical Compounds of Ethanolic Extract of Gigantochloa scortechinii Rhizome

Johar Mohamed, Hazandy Abdul Hamid, Ahmad Ainuddin Nuruddin, Nik Muhammad Nik Abdul Majid

Subject: Chemistry, Organic Chemistry Keywords: spatial; age-related; phytochemical; bamboo; rhizome; GC-MS

Online: 7 September 2018 (03:01:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0528.v1

The Effects of Intermittent Fasting on Brain and Cognitive Function

Jip Gudden, Alejandro Arias Vasquez, Mirjam Bloemendaal

Subject: Medicine & Pharmacology, Nutrition Keywords: Intermittent fasting; cognition; brain-related diseases; prevention and progress

Online: 27 August 2021 (16:22:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0350.v2

Recent Advances in Proteomic-based Approaches to Study Age-related Macular Degeneration: A Systematic Review

Laura García-Quintanilla, Lorena Rodríguez-Martínez, Enrique Bandín-Vilar, María Gil-Martinez, Miguel González-Barcia, Cristina Mondelo-García, Anxo Fernández-Ferreiro, Jesús Mateos

Subject: Life Sciences, Molecular Biology Keywords: Proteomics, Age-related macular degeneration, inflammation, biomarker, oxidative stress.

Online: 21 November 2022 (02:35:09 CET)

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Working Paper ARTICLE

Behavioral, Emotional and Social Apathy in Alcohol-Related Cognitive Disorders

Maud E.G. van Dorst, Yvonne C.M. Rensen, Masud Husain, Roy P.C. Kessels

Subject: Behavioral Sciences, Applied Psychology Keywords: apathy; neuropsychology; Korsakoff’s syndrome; alcohol use disorder; alcohol-related cognitive disorders

Online: 8 April 2021 (10:12:13 CEST)

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Working Paper REVIEW

Does the Prevalence of Fabella Vary in Knee Osteoarthritis and Age-Related Degeneration? A Meta-Analysis of over 11,000 Knees

Adil Asghar, Shagufta Naaz, Ravi Kant Narayan, Anup Kumar

Subject: Medicine & Pharmacology, General Medical Research Keywords: Odds Ratio; Prevalence; Knee Joints; Osteoarthritis (OA); Age-related degeneration (ARD)

Online: 7 July 2020 (03:01:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0347.v2

Inhibition of Experimental Choroidal Neovascularization by a Novel Peptide Derived from Calreticulin Anti-Angiogenic Domain

Youn-Shen Bee, Yi‐Ling Ma, Jinying Chen, Pei-Jhen Tsai, Shwu-Jiuan Sheu, Hsiu-Chen Lin, Hu Huang, Guei-Sheung Liu, Ming-Hong Tai

Subject: Medicine & Pharmacology, Ophthalmology Keywords: choroidal neovascularization; neovascular age-related macular degeneration; calreticulin anti-angiogenic domain

Online: 18 September 2018 (06:27:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0102.v1

Age-Related Diseases as Vicious Cycles

Aleksey V. Belikov

Subject: Medicine & Pharmacology, Pathology & Pathobiology Keywords: aging; age-related disease; mortality rate; positive feedback loop; vicious cycle

Online: 18 April 2017 (02:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0359.v1

Chlorpyrifos- and Dichorfos-Induced Oxidative and Neurogenic Damage Elicits Neuro-Cognitive Deficits and Increases Anxiety-Like Behaviors in Wild-Type Rats

Aminu Imam, Nafeesah Abdulkareem Sulaiman, Aboyeji Lukuman Oyewole, Samson Chengetanai, Victoria Williams, Musa Iyiola Ajibola, Royhaan Olamide Folarin, Asma'u Shehu Muhammad, Sheu-Tijani Toyin Shittu, Salihu Moyosore Ajao

Subject: Medicine & Pharmacology, Pharmacology & Toxicology Keywords: oxidative damage; organophosphates; neurotoxicity; spatial working memory; anxiety-related behaviors

Online: 16 October 2018 (12:04:13 CEST)

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The mechanization of agricultural activities has led to indiscriminate deposition of toxic xenobiotics, including organophosphates in the biomes, and this has led to intoxication characterized with deleterious oxidative and neuronal changes. This study investigated the consequences of oxidative and neurogenic disruptions that follow exposure to two organophosphates, chlorpyrifos (CPF) and dichlorvos (DDVP) on neuro-cognitive performance and anxiety-like behaviors in rats Thirty-two adult male Wistar rats (150 – 170g) were randomly divided into 4 groups, orally exposed to normal saline (NS), DDVP (8.8mg/kg), CPF (14.9mg/kg) and DDVP+CPF for 14 consecutive days. On day 10 of exposures, anxiety-like behaviors and amygdala dependent fear learning were assessed using Open Field and Elevated Plus Maze paradigms respectively, while spatial working memory was assessed on day 14 in the Morris water maze paradigm, following 3 training trials each on days 11, 12 and 13. On day 15, the rats were euthanized, and their brains excised, hippocampus and amygdala removed, 5 of which were homogenized and centrifuged to analyze nitric oxide (NO) metabolites, total reactive oxygen species (ROS), and acetylcholinesterase (AChE) activity, and the other three processed for histology (cresyl violet stain) and proliferative marker (Ki67 immunohistochemistry). Marked (p≤0.05) loss in body weight, AChE depletion, and overproduction of both NO and ROS were observed after repeated exposure to individual and combined doses of CPF and DDVP. Insults from DDVP exposure appeared more severe owing to the observed greater losses in the body weights of exposed rats. There was also a significant (p≤0.05) effect on the cognitive behaviors recorded from the exposed rats, and these deficits were related to the oxidative damage and neurogenic cell loss in the hippocampus and the amygdala of the exposed rats. Taken together, these results provided an insight that oxidative and neurogenic damages are central to the severity of neuro-cognitive dysfunction and increased anxiety-like behaviors that follow organophosphate poisoning.

Preprint ARTICLE | doi:10.20944/preprints202106.0585.v1

Topical Triamcinolone Acetonide-Loaded Liposomes Formulation Used as an Adjuvant to Intravitreal Ranibizumab Therapy for Neovascular Age Related Macular Degeneration

Jose Navarro-Partida, Juan Carlos Altamirano-Vallejo, Luis Abraham Aceves Franco, Jesús Gonzalez-Cortes, Sergio Hernandez Da Mota, Jose Gerardo García-Aguirre, Carlos David Azuara-Galindo, Carlos Rodrigo Castro-Castaneda, Juan Armendariz-Borunda, Arturo Santos

Subject: Medicine & Pharmacology, Allergology Keywords: Triamcinolone acetonide; Liposomes; Neovascular age related macular degeneration; Wet macular degeneration; Adjuvant therapy; Ranibizumab

Online: 23 June 2021 (12:56:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0081.v3

Developing and Validating an Age-Independent Equation Using Multi-Frequency Bioelectrical Impedance Analysis for Estimation of Appendicular Skeletal Muscle Mass and Establishing a Cutoff for Sarcopenia

Yosuke Yamada, Miyuki Nishizawa, Tomoka Uchiyama, Yasuhiro Kasahara, Mikio Shindo, Motohiko Miyachi, Shigeho Tanaka

Subject: Medicine & Pharmacology, Nutrition Keywords: age-related skeletal muscle loss; sarcopenia; malnutrition risk assessment; DXA; multi-frequency BIA; aging

Online: 23 August 2017 (17:57:14 CEST)

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Background: Appendicular skeletal muscle (or lean) mass (ALM) estimated using dual-energy X-ray absorptiometry (DXA) is considered to be a preferred method for sarcopenia studies. However, DXA is expensive, has limited portability, and requires radiation exposure. Bioelectrical impedance analysis (BIA) is inexpensive, easy to use, and portable; thus BIA might be useful in sarcopenia investigations. However, a large variety of models have been commercially supplied by different companies, and for most consumer products, the equations estimating ALM are not disclosed. It is therefore difficult to use these equations for research purposes. In particular, the BIA equation is often age-dependent, which leads to fundamental difficulty in examining age-related ALM loss. The aims of the current study were as follows: (1) to develop and validate an equation to estimate ALM using multi-frequency BIA (MF-BIA) based on theoretical models, and (2) to establish sarcopenia cutoff values using the equation for the Japanese population. Methods: We measured height (Ht), weight, and ALM obtained using DXA and a standing-posture 8-electrode MF-BIA (5, 50, 250 kHz) in 756 Japanese individuals aged 18 to 86-years-old (222 men and 301 women as developing equation group and 97 men and 136 women as a cross validation group). The traditional impedance index (Ht²/Z₅₀) and impedance ratio of high and low frequency (Z₂₅₀/Z₅) of hand to foot values were calculated. Multiple regression analyses were conducted with ALM as dependent variable in men and women separately. Results: We created the following equations: ALM = (0.6947 × (Ht²/Z₅₀)) + (−55.24 × (Z₂₅₀/Z₅)) + (−10,940 × (1/Z₅₀)) + 51.33 for men, and ALM = (0.6144 × (Ht²/Z₅₀)) + (−36.61 × (Z₂₅₀/Z₅)) + (−9332 × (1/Z₅₀)) + 37.91 for women. Additionally, we conducted measurements in 1624 men and 1368 women aged 18 to 40 years to establish sarcopenia cutoff values in the Japanese population. The mean values minus 2 standard deviations of the skeletal muscle mass index (ALM/Ht²) in these participants were 6.8 and 5.7 kg/m² in men and women, respectively. Conclusion: The current study established and validated a theoretical and age-independent equation using MF-BIA to estimate ALM and provided reasonable sarcopenia cutoff values.

Preprint REVIEW | doi:10.20944/preprints202211.0320.v1

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan

Arastu Sharma, Sophie Chabloz, Elisabeth M. Roider, Collin Y. Ewald

Subject: Biology, Physiology Keywords: aging; longevity; supplements; geroprotectors; SIRT1; NAD+; NMN; resveratrol; nutraceuticals; age-related diseases; flavonoids; senolytics; healthspan

Online: 17 November 2022 (02:51:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0224.v1

SIG-1451, A Novel, Non-Steroidal Anti-Inflammatory Compound, Attenuates Light-Induced Photoreceptor Degeneration by Inhibiting Microglial Activation

Yuki Kikuchi, Eriko Sugano, Shiori Yuki, Kitako Tabata, Yuka Endo, Yuya Takita, Reina Onoguchi, Taku Ozaki, Tomokazu Fukuda, Yoshihiro Takai, Takahiro Kurose, Koichi Tanaka, Yoichi Honma, Eduardo Perez, Maxwell Stock, Jose Fernandez, Masanori Tamura, Michael Voronkov, Jeffry B Stock, Hiroshi Tomita

Subject: Life Sciences, Molecular Biology Keywords: age-related macular degeneration; light-induced photoreceptor degeneration; anti-inflammatory drug; toll-like receptor 4

Online: 17 May 2022 (08:03:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0184.v1

Tissue Engineering Strategies for Retinal Regeneration

Deepthi. S RajendranNair, Magdalene.J Seiler, Kahini Patel, Vinoy Thomas, Juan Carlos Martinez, Mark.S Humayun, Biju. B Thomas

Subject: Materials Science, Biomaterials Keywords: Retinal degenerative diseases; Age related macular degeneration; Biomaterials, Stem cells, Retinal pigment epithelium; Tissue engineering

Online: 8 February 2021 (10:46:50 CET)

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Preprint REVIEW | doi:10.20944/preprints201801.0269.v1

Impaired Cargo Clearance in the Retinal Pigment Epithelium (RPE) Underlies Irreversible Blinding Diseases

Eloise Keeling, Andrew J. Lotery, David A. Tumbarello, J. Arjuna Ratnayaka

Subject: Medicine & Pharmacology, Ophthalmology Keywords: Retinal Pigment Epithelium (RPE); endosomes; phagosomes; lysosomes, autophagy; RPE cultures; Age-related Macular Degeneration (AMD)

Online: 29 January 2018 (08:07:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0066.v1

Comparison of Antioxidant Properties of Dehydrolutein with Lutein and Zeaxanthin, and their Effects on Retinal Pigment Epithelial Cells

Malgorzata Rozanowska, Barbara Czuba-Pelech, John T. Landrum, Bartosz Rozanowski

Subject: Life Sciences, Biochemistry Keywords: carotenoid; lutein; zexanthin; dehydrolutein; retina; retinal pigment epithelium; singlet oxygen; photosensitized oxidation; age-related macular degeneration.

Online: 2 April 2021 (14:04:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0197.v1

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Duc Le, Lindsay Brown, Kundan Malik, Shin Murakami

Subject: Medicine & Pharmacology, Cardiology Keywords: AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance

Online: 13 October 2021 (11:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0392.v1

A Fusion Learning Method for the Age-Related Macular Degeneration Diagnosis Based on Multiple Sources of Ophthalmic Digital Images

Han Wang, Junjie Zhou, Zhoujie Tang, Chengde Huang, Jie Yang, Yi Pan, Kelvin KL Chong

Subject: Life Sciences, Biotechnology Keywords: Age-related Macular Degeneration; Artificial Intelligence; Machine Learning; Optical Coherence Tomography; Fundus Autofluorescence; regular fundus photography; Ultra-Widefield Fundus

Online: 21 November 2022 (12:14:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201902.0101.v1

Therapeutic Approaches with Intravitreal Injections in Geographic Atrophy Secondary to Age-Related Macular Degeneration: Current Drugs and Potential Molecules

Marcella Nebbioso, Alessandro Lambiase, Alberto Cerini, Paolo Giuseppe Limoli, Maurizio La Cava, Antonio Greco

Subject: Medicine & Pharmacology, Ophthalmology Keywords: age-related macular degeneration; anti-inflammatory agents; dry AMD; geographic atrophy; intravitreal injection; complement inhibitors; neuroprotective agents; non-exudative AMD

Online: 12 February 2019 (11:00:52 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0369.v1

The Role of Diet, Micronutrients and the Gut Microbiota in Age-Related Macular Degeneration: New Perspectives from the Gut-Retina Axis

Emanuele Rinninella, Maria Cristina Mele, Nicolò Merendino, Marco Cintoni, Gaia Anselmi, Aldo Caporossi, Antonio Gasbarrini, Angelo Maria Minnella

Subject: Medicine & Pharmacology, Nutrition Keywords: Age-Related Macular Degeneration, Gut-retina axis, Gut microbiota, Dietary habits, Micronutrients, Fish oil, omega-3 Polyunsaturated fatty acids, Personalised medicine

Online: 16 October 2018 (17:39:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0532.v3

Examining the Role of the Noradrenergic Locus Coeruleus for 2 Predicting Attention and Brain Maintenance in Healthy Old Age 3 and Disease: An MRI Structural Study for the Alzheimer’s Disease 4 Neuroimaging Initiative

Emanuele Raffaele Giuliano Plini, Erik O'Hanlon, Rory Boyle, Francesca Sibilia, Gaia Rikhye, Joanne Kenney, Robert Whelan, Michael Christopher Melnychuk, Ian Hamilton Robertson, Paul Michael Dockree

Subject: Behavioral Sciences, Applied Psychology Keywords: Locus Coeruleus; Reserve; Brain Age; Visual Attention; Alzheimer’s Disease; Mild Cognitive Impairment; normal Aging; Neuroimaging; Voxel Based Morphometry

Online: 21 June 2021 (11:41:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0094.v1

An Unexpected Role for GPR143 in Retinal Homeostasis

Dorothy Tung, Nicole R. Congrove, Anna Gabriela Figueroa, Remington M Bliss, Tawanda Zvavamwe, Brian S. McKay

Subject: Life Sciences, Cell & Developmental Biology Keywords: Retinal pigment epithelium of the eye; RPE; AMD (Age-related Macular Degeneration); GPR143; L-DOPA; Melanin; Ocular albinism; Exosome; Photoreceptor outer segment; Cathepsin D.

Online: 5 January 2023 (02:58:31 CET)

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Age-related macular degeneration is one of the most common causes of blindness, and the incidence exhibits profound racial bias, occurring most frequently in Caucasians. A primary cell type affected in the disease is the retinal pigment epithelium, but the etiology is unclear. The end 10% of the photoreceptor outer segments are shed each day, and the underlying retinal pigment epithelium engulfs, digests, and recycles molecules back to the sensory retina. In previous work, we showed that GPR143 signaling in response to L-DOPA may be effective in the prevention or delay of age-related macular degeneration. In this study, we explore a novel potential effector of GPR143 signaling, that of outer segment uptake and digestion. Using isolated outer segments, labelled with a pH-sensitive marker to fluoresce in lysosomes, we show that GPR143 signaling does not impact outer segment uptake, but does have a significant effect on subsequent degradation. Interestingly, GPR143 signaling did not affect the digestive capacity of the cells, marked by total proteolytic capacity and cathepsin D activity. Rather, our data suggest GPR143 improved endosomal trafficking efficiency of the phagocytosed outer segments to the lysosome. This result is similar to the effect we previously reported for GPR143 on exosome release from the endosomal compartment. Our data illustrate that GPR143 is active in endosomal traffic A single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: Place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: briefly describe the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article and it must not contain results that are not presented and substantiated in the main text and should not exaggerate the main conclusions.

Preprint ARTICLE | doi:10.20944/preprints202006.0081.v2

Measuring Independent and Controlled Effects of Age at Marriage and Age at First Birth on Completed Family Size among women aged 45-59 in Zambia

Nkuye Moyo, Tina Nanyangwe-Moyo, Xiaochun Qiao, Jilei Wu, Xiaoying Zheng

Subject: Keywords: age at first marriage; age at first birth; completed family size; fertility

Online: 13 October 2020 (14:17:28 CEST)

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Background The link between age at marriage and first birth in explaining completed family size is not always direct, due to heterogeneity in circumstances, that compel individual women to marry or initiate childbearing at a particular age. We analyzed data for 1020 women aged 45-49 in 2014 of the 1965-1969 birth cohort from the 2013-14 Zambia Demographic and Health Survey (ZDHS). Methods We fitted a bivariate and multivariate multinomial logistic regression to establish the relationship between a mother’s age at first marriage and at first birth on completed family size (CFS). Chi-square test of proportions measuring differences in proportions and relative risk ratios (RRR) with confidence intervals at 95% are reported. Results Our results show that the average CFS was 6.7 (95% CI: 6.5 – 6.9) among women completing their reproductive span in 2014 with mean age at first marriage and birth being 18.3 years (95% CI: 18.0 – 18.5) and 18.9 years (95% CI: 18.7 – 19.1) respectively. Women marrying at younger ages and having their first birth at younger ages were more likely (RRR: 1.187; 95% CI: 1.138-1.239 and RRR: 0.195; 95% CI: 0.074-0.511 respectively) to have higher CFS than their compatriots that initiated both marriage and childbearing at or after age 22 controlling for covariates as presented in the controlled model. The independent effects model shows that the risk of having 1-3 children compared to 6 or more children was lower (RRR: 0.073; 95% CI: 0.009-0.611; RRR: 0.136; 95% CI: 0,046-0.402 and RRR: 0.421; 05% CI: 0.135-1.312) for women whose ages at first marriage were <15, 15-18 and 19-21 respectively relative to 22+. Women with 1-3 children were 2.5 times more likely to use contraception than women with 6 or more children. Conclusion Having no education, being a rural resident and having a medium household wealth all increase the risk of having higher CFS. Women that marry before age 19 have a higher likelihood of having 6 or more children by the end of their reproductive period. The study concludes that apart from a woman’s age at first marriage and first birth, a complex network of factors interact to determined CFS.

Preprint ARTICLE | doi:10.20944/preprints202201.0030.v1

Practical Application of Nanotechnology Solutions in Pavement Engineering: Addressing Practical Road Construction Related Problems Using Marginal Materials Stabilised With New-Age (Nano) Modified Emulsions (Nme) Towards Sustainable Roads

Gerrit J Jordaan, Wynand J vdM Steyn

Subject: Engineering, Civil Engineering Keywords: New-age (Nano) Modified Emulsion (NME) stabilisation; identifying construction problems; preventing construction related problems; material related problems; constructability using nanotechnology applications; nano-silane stabilisation of granular materials; construction quality control problems; construction equipment problems; practical implementation of nano-silane stabilisation.

Online: 11 January 2022 (10:37:34 CET)

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Preprint REVIEW | doi:10.20944/preprints201901.0039.v1

Prevention of Hearing Loss by Alteration of the Systemic Immune System

Hiroshi Iwai, Muneo Inaba

Subject: Medicine & Pharmacology, General Medical Research Keywords: autoimmune sensorineural hearing loss; age-related sensorineural hearing loss; inflammation, immune senescence; interleukin 1 receptor type II -positive T cells; naturally occurring regulatory T cells; immune rejuvenation; thymus

Online: 4 January 2019 (11:37:31 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202110.0386.v1

Causes and Treatment of Hypoxia During Total Hip Arthroplasty in Elderly Patients: Case Report

Jae Young Ji, Jin Hun Chung, Nan Seol Kim, Yong Han Seo, Ho Soon Jung, Hea Rim Chun, Hyung Yoon Gong, Woo Jong Kim, Jae Min Ahn, Yu Jun Park

Subject: Medicine & Pharmacology, Anesthesiology Keywords: Atelectasis; Hypoxia; Old age; Spontaneous respiration

Online: 26 October 2021 (12:36:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0245.v1

Post Vaccination Titers of Serum Anti-Diphtheria in Indonesian Young and Middle-Aged Adults

Gatot Soegiarto, Diksi Novritasari, Ari Baskoro, Deasy Fetarayani, Wita Kartika Nurani

Subject: Medicine & Pharmacology, Other Keywords: Age; Antibody titers; Diphtheria; Immunosenescence; Vaccine

Online: 12 July 2021 (11:33:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0501.v1

Age-dependent Non-silent Somatic Mutation with Transcriptomic Landscape and Prognosis of Lower Grade Glioma

YoungJoon Park, JeongMan Park, Ju Won Ahn, JeongMin Sim, Su Jung Kang, Suwan Kim, Sojung Hwang, Kyoung Su Sung, Jaejoon Lim

Subject: Keywords: age; glioma; mutation; TCGA; transcriptomic analysis

Online: 23 February 2021 (08:16:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0029.v1

Gender, Age, Year of Course and Faculty: Factors Influencing the Risk of Eating Disorders

María-Camino Escolar-Llamazares, María-Ángeles Martínez-Martín, María-Begoña Medina-Gómez, María-Yolanda González-Alonso, Elvira Mercado-Val, Fernando Lara-Ortega

Subject: Behavioral Sciences, Applied Psychology Keywords: eating disorder; gender; age; university degree

Online: 1 February 2021 (12:58:08 CET)

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Preprint EDITORIAL | doi:10.20944/preprints201608.0130.v1

What Is the Main Cause of Cancer?

Miguel López-Lázaro

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: carcinogenesis; cancer; age distribution of cancer

Online: 11 August 2016 (11:40:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0040.v1

Fеаtures of Emotional Sphere of Adolescents of Different Ethnic Groups of Northeast Russia

Tatiana Bartosh, Olga Bartosh

Subject: Behavioral Sciences, Applied Psychology Keywords: adolescents; emotional sphere; ethnic-related peculiarities; North

Online: 3 March 2020 (11:33:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0019.v1

Glacier Recession in Altay Mountains after the LIA Maximum

Dmitry Ganyushkin, Kirill Chistyakov, Ekaterina Derkach, Dmitriy Bantcev, Elena Kunaeva, Anton Terekhov, Valeriia Rasputina

Subject: Earth Sciences, Environmental Sciences Keywords: glaciers; Little Ice Age; reconstruction; retreat; Altai

Online: 4 January 2022 (20:30:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0210.v1

Metabolomic Characterization of Olive Xylem Sap Reveals Differences According to Plant Age and Genotype

Manuel Anguita-Maeso, Carmen Haro, Miguel Montes-Borrego, Leonardo De La Fuente, Juan A. Navas-Cortés, Blanca B. Landa

Subject: Life Sciences, Biochemistry Keywords: olive; xylem sap; metabolomics; plant age; genotype

Online: 8 March 2021 (10:56:37 CET)

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Vascular pathogens are the causal agents of main diseases threatening the health and growth of olive crops worldwide. The use of endophytic microorganisms represents a challenging and promising strategy for management of vascular diseases in olive. Although current research has been focused on analyzing the structure and diversity of the endophytic microbial communities inhabiting the olive xylem, the characterization of this ecological niche has been overlooked and to date remain unexplored, despite that the characterization of the xylem sap composition is essential to unravel the nutritional requirements of xylem-limited microorganisms. In this study, branches from plantlets and adult olive trees of cultivars ‘Picual’ and ‘Arbequina' were selected to characterize the chemical composition of olive xylem sap extracted using a Scholander pressure chamber. Metabolome and ionome analyses of xylem sap were performed by proton nuclear magnetic resonance (NMR) spectroscopy-based and by inductively coupled plasma with optical emission spectroscopy (ICP-OES), respectively. Olive xylem sap metabolites included a higher relative percentage of sugars (54.35%), followed by alcohols (28.85%), amino acids (8.01%), organic acids (7.68%) and osmolytes (1.12%). Within each of these groups, the main metabolites in the olive xylem sap were mannitol, ethanol, glutamine, acetate and trigonelline, whereas K and Cl- were the main element and inorganic anion, respectively. Metabolomic profile varied when comparing olive plant age and genotype. The levels of glucose, fructose, sucrose and mannitol, choline, B and PO43 were significantly higher in adult trees than in plantlets for both olive genotypes, whereas NO3- and Rb content showed the opposite behavior. On the other hand, levels of aspartate, phenylalanine and Na were significantly higher in ‘Picual’ than in ‘Arbequina’ whereas Fe showed the opposite behavior but only for adult trees. Non-supervised hierarchical clustering analysis separated xylem sap composition firstly according to the plant age and then by the olive cultivar. Supervised PLS-DA analysis revealed that B, ethanol, Fe, Fructose, glucose, mannitol, sucrose and Sr were the most significative compounds discriminating adult trees from plantlets, whereas asparagine, aspartate, glutamate and phenylalanine or aspartate, arginine, ethanol and Sr were the most contributory compounds in the discrimination of both olive genotypes for adult trees or plantlets, respectively. Knowledge of the chemical composition of xylem sap will lead to a better understanding of the complex nutritional requirements of olive xylem-inhabiting microorganisms, including its vascular pathogens, and would allow the design of artificial growing media to improve culturing the olive microbiome.

Preprint ARTICLE | doi:10.20944/preprints201808.0025.v1

Health and Aging: Unifying Concepts, Scores, Biomarkers and Pathways

Georg Fuellen, Ludger Jansen, Alan A. Cohen, Walter Luyten, Manfred Gogol, Andreas Simm, Nadine Saul, Francesca Cirulli, Alessandra Berry, Peter Antal, Rüdiger Köhling, Steffen Möller

Subject: Medicine & Pharmacology, General Medical Research Keywords: terminology, health, aging, biological age, wellbeing, biomarker

Online: 1 August 2018 (15:00:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0402.v1

Tuberculosis among Peoples Who Were Living on the Street and Used Alcohol, Tobacco, and Illegal Drugs: Analysis of Territories in Extreme Vulnerability and Trends in Southern Brazil

Alessandro Rolim Scholze, Josilene Dália Alves, Thaís Zamboni Berra, Antônio Carlos Vieira Ramos, Flávia Meneguetti Pieri, Sandra Cristina Pillon, Júlia Trevisan Martins, Maria José Quina Galdino, Emiliana Cristina Melo, Felipe Mendes Delpino, Inês Fronteira, Ricardo Alexandre Arcêncio

Subject: Life Sciences, Other Keywords: Tuberculosis; Vulnerable populations; Homeless Persons; Substance-Related Disorders

Online: 31 March 2022 (08:05:32 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202109.0148.v1

Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies

Roshan Roy, Uttam Sharma, Rakhi Yadav, Manjit Kaur Rana, Ashok Sharma, Pranay Tanwar, Aklank Jain, Hridayesh Prakash

Subject: Life Sciences, Immunology Keywords: Cancer related Inflammation; miRNA; LncRNA; Epigenetics, immune polarization

Online: 8 September 2021 (12:07:58 CEST)

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Working Paper CASE REPORT

Antonio Tombolini

Subject: Medicine & Pharmacology, Allergology Keywords: fire-related death; viability; light microscopy; bronchiolar epithelium

Online: 25 February 2021 (13:12:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0015.v1

Knut Brockow, Katarzyna Plata-Nazar, Magdalena Lange, Bogusław Nedoszytko, Marek Niedoszytko, Peter Valent

Subject: Medicine & Pharmacology, Allergology Keywords: mast cells; mastocytosis; mediator-related symptoms; anaphylaxis; children

Online: 1 February 2021 (11:36:31 CET)

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Working Paper REVIEW

Effectiveness of Chitosan as a Dietary Supplement in Lowering Cholesterol in Murine Models: A Meta-analysis

Sung-Il Ahn, Sangbuem Cho, Nag-Jin Choi

Subject: Medicine & Pharmacology, Allergology Keywords: meta-analysis; chitosan; lifestyle-related disease; cholesterol lowering

Online: 18 November 2020 (10:59:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0392.v1

Amani Zidan, Ahmed Awaisu, Maguy El-Hajj, Samya Al-Abdulla, Dianne Figueroa, Nadir Kheir

Subject: Medicine & Pharmacology, Other Keywords: Medication-related burden; Questionnaire; chronic disease conditions; adherence

Online: 25 June 2018 (14:35:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0534.v1

Towards An Integral Therapeutic Protocol for Breast Cancer based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Salvador Harguindey, Khalid Alfarouk, Julián Polo Orozco, Stefano Fais, Jesús Devesa

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: breast cancer etiopathogenesis; breast cancer treatment; hydrogen ion dynamics of cancer; pH-related paradigm; H+-related therapeutics of breast cancer

Online: 23 September 2020 (04:04:24 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202107.0075.v1

Accurate Epigenetic Aging in Bottlenose Dolphins (Tursiops Truncatus), an Essential Step in the Conservation of at-Risk Dolphins.

Ashley Barratclough, Cynthia R. Smith, Forrest M. Gomez, Theoni Photopoulou, Ryan Takeshita, Enrico Pirotta, Len Thomas, Abby M. McClain, Celeste Parry, Joseph A Zoller, Steve Horvath, Lori H Schwacke

Subject: Biology, Anatomy & Morphology Keywords: DNA methylation; epigenetic aging; bottlenose dolphin; chronological age

Online: 5 July 2021 (07:59:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0200.v1

Comparison of Gender, Age, and Body Mass Index Levels for Spatiotemporal Parameters of Bilateral Gait Pattern

Turki S. Abualait, Mohammad Ahsan

Subject: Medicine & Pharmacology, Sport Sciences & Therapy Keywords: spatiotemporal parameters; gait; gender; age; Body Mass Index

Online: 9 September 2020 (07:12:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0367.v1

Epidemiological Characteristics of Early COVID-19 Case Outbreaks in Indonesia

Abu Bakar, Triyono Indrasiwi Kuncoroaji, Andy Lee, Shih-Chieh Lee, Valendriyani Ningrum

Subject: Medicine & Pharmacology, Other Keywords: Confirmed cases, case fatality rate, province, age, gender.

Online: 17 July 2020 (06:24:55 CEST)

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The initial outbreak of COVID-19 was first reported in Wuhan (China) during the latter part of December 2019. Indonesia has the fourth-largest population globally and reported the country’s first case of the virus on 2nd March 2020. The World Health Organisation (WHO) in addition to several neighbouring provinces and educational institutions within the region began questioning the Indonesian government upon the initial case reported. The objective of this study was to describe the epidemiological characteristics of the COVID-19 outbreak in Indonesia during March 2020. The data were collected from Indonesian government databases and non-government organisations (NGOs). The data were analysed using Microsoft Office 2019 (Excel) and Adobe Illustrator 2017 software, was used in drawing the map depicting the distribution of COVID-19 in Indonesia. As at 31st March 2020, a total of 1,528 people in Indonesia have been infected by COVID-19, in addition to 136 mortalities (CFR of 8.9%). Jakarta, as the principal capital of Indonesia, quickly has become the epicentre of the virus since this period. Most patient cases were attributed to those aged between 31 and 70 years (72.64%), with male patients (64.93%) representing the highest incidence of cases compared to female patients (35.07%). The number of ventilating machines was 3,326, with hospital numbers at 859. The distribution of cases depicting COVID-19 was mainly seen in urban areas compared to rural areas. Males compared to females, are at a higher risk of contracting COVID-19, including those aged below 30, between 30 and 60 or above. Indonesia also has the highest case fatality rate (CFR) with respect to mortalities in Southeast Asia and has the second-highest CFR globally. Similarly, while the number of ventilator machines as at 31st March 2020 were sufficient in meeting the growing number of COVID-19 cases in the country, it is possible that the government may need to increase the number of ventilators if the cases continue to escalate.

Preprint ARTICLE | doi:10.20944/preprints201911.0335.v1

Socio-Moral Development of Preschool Children: Aspects of Theory and Practice

Evgenia Korotaeva, Irina Chugaeva

Subject: Behavioral Sciences, Social Psychology Keywords: social and moral education; preschool age; communitarian approach

Online: 27 November 2019 (08:46:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0106.v1

Comparative Assessment of Age, Growth and Food Habit of the Black-Chinned Tilapia, Sarotherodon melanotheron (Rüppell, 1852), from Closed and Open Lagoons, Ghana

Cephas Kwesi Zuh, Seth Mensah Abobi, Benjamin Betey Campion

Subject: Biology, Ecology Keywords: Ghana; lagoon; tilapia; fish growth; otoliths; age; food

Online: 12 February 2019 (17:14:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0187.v1

Determining Oil Palm Stands Age Using Multi Temporal Images Analysis

Anggoro Cahyo Fitrianto, Doddy Mendro Yuwono, Arif Darmawan, Koji Tokimatsu

Subject: Earth Sciences, Environmental Sciences Keywords: remote sensing; multi-temporal; Landsat; age; canopy; FCD

Online: 9 October 2018 (11:33:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0137.v1

Gimbutas’ Smile – An Archaeology Led, Archaeogenetic Model

Bob Kenyon

Subject: Arts & Humanities, Archaeology Keywords: Archaeology; Archaeogenetic Model; Neolithic; Chalcolithic; Bronze Age; Migration

Online: 19 December 2017 (15:49:22 CET)

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Migrations are much more important than currently recognised, for explaining important patterns observed in the European archaeology record – according to this archaeology led model. At a high level, they explain the introduction of different farming, monument building, the spread of metalworking and patterns of trade and exchange. This paper presents an archaeogenetic model based on a strategic review of the Neolithic and Chalcolithic archaeology of Europe, alongside a review of recently published ancient DNA data. The model is archaeology led. It takes archaeology themes and proposes migratory events to explain them. Ancient DNA data and further archaeology evidence is then used to test these proposed migrations- to reject or refine them. The model introduces a new and more strategic way of looking at archaeological cultures - that updates early 20th century approaches to studying archaeology cultures, and integrates with the detailed ‘post processual’ studies of the late 20th Century. The model consists of seven maps – each showing multiple migration events – with key evidence to support each migration map. It proposes a new category of a ‘Black Sea’ related population that makes a major genetic contribution to the Middle Neolithic of Europe. The proposed migrations provide an explanation for the observed patterns of archaeology, for example: • multiple Neolithic migrations that introduced, farming and metalworking into Europe; • a major ‘Black Sea’ related ‘Middle Neolithic’ migration that carried advanced knowledge of astronomy that can be recognised in a variety of types of monument from the Neolithic through to Bronze Age Europe; and, • migrations of related cultures (‘supercultures’) that explain patterns of trade and exchange in Bronze Age western Europe. The model also provides ancient DNA and archaeology based support for the key aspects of Childe’s ‘dawn of civilisation’ in Europe and Egypt and Gimbutas’ ‘Old Europe’ and “three waves of migration from the Steppe”.

Preprint ARTICLE | doi:10.20944/preprints201709.0016.v1

Responses of Soil Microbial Communities to Robinia Pseudoacacia Plantations of Different Ages in A Loess Area

Bingxue Zhang, Rumeng Zhao, Boyuan Bi, Fengpeng Han

Subject: Biology, Forestry Keywords: soil; Robinia pseudoacacia; PLFA; stand age; microbial community

Online: 5 September 2017 (15:28:05 CEST)

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Phospholipid fatty acids (PLFAs) can be used as biomarkers for qualitative and quantitative analyses of soil microbial community diversity. In this study, we collected soil samples at 10-cm intervals to a depth of 1 m from Robinia pseudoacacia plantations of four different ages (10, 15, 25 and 40 years) in a loess area and analysed the soil microbial community structure by PLFA analysis. A total of 97 PLFAs were detected in soils of R. pseudoacacia plantations of different ages. The individual PLFA contents gradually decreased in the 0- to 40-cm soil layers, with little variation in the 40- to 100-cm soil layers. The individual PLFAs were similarly distributed in the soils of R. pseudoacacia plantations of different ages, and there was a clear variation with stand age and soil depth. The individual PLFA contents in the 0- to 20-cm soil layers were highest for the 25-year-old plantation, while those in the 20- to 40-cm soil layers were relatively high for the 25- and 40-year-old plantations; the 16:0 content was the highest among individual PLFAs. The total PLFA content and the PLFA contents of different microbial groups [bacteria, fungi, Gram-positive bacteria (G⁺), Gram-negative bacteria (G^-) and actinomycetes] initially increased before decreasing in the soils of R. pseudoacacia plantations with increasing stand age, whereas these contents gradually decreased with increasing soil depth; the highest PLFA contents was found in the 25-year-old plantation. The total PLFA content and the contents of fungal, G^- and actinomycete PLFAs in the soils of R. pseudoacacia plantations differed significantly among stands of different ages in the 0- to 10-cm, 10- to 20-cm and 30- to 40-cm soil layers, while no significant differences were found in the 20- to 30-cm soil layers; the G⁺ and bacterial PLFAs contents in each of the 0- to 40-cm soil layers were significantly different. The PLFA ratios between different microbial groups differed among the stands of different ages. The fungi/bacteria ratio showed a “decrease-increase-decrease” trend with stand age, while the G⁺/G^- ratio showed an “increase-decrease” trend. The saturated/monounsaturated PLFA ratio initially decreased before plateauing, while the opposite trend was observed for the cyclopropyl/precursor ratio. The PLFA contents of different microbial groups were ranked as follows: bacteria > G^- > G⁺ > actinomycetes > fungi. In the principle component analysis, 18:1ω9c, 10Me18:0, i17:0, a17:0, 18:1ω7c, 18:1ω5c and 18:0 made the greatest contribution to principal component 1, and a14:0, i14:0 3OH, i14:0, i14:1ω7c and 14:0 made the greatest contribution to principal component 2. In conclusion, soil nutrient status and other soil eco-environmental stress factors should be considered in 10- to 25-year-old (particularly ~15-year-old) plots for the management of R. pseudoacacia plantations to prevent forest soil degradation and improve forest stand quality, thereby achieving better soil and water conservation and environmental improvement in R. pseudoacacia plantations.

Preprint ARTICLE | doi:10.20944/preprints202207.0351.v1

Almamy Amara Touré, Aboubacar Sidiki Magassouba, Gnoume Camara, Abdoulaye Doumbouya, Diao Cissé, Ibrahima Barry, Lansana Mady Camara, Abdoul Habib Béavogui, Alexandre Delamou, Vanessa Veronese, Corinne Simone Merle, Hugues Asken Traoré, Adama Marie Bangoura

Subject: Life Sciences, Other Keywords: Tuberculosis; Health-related quality of life; COVID-19; Guinea

Online: 25 July 2022 (05:37:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0389.v1

Dynamics of Gut Microbiome and Transcriptome in Korea Native Ricefish (Oryzias latipes) during Chronic Antibiotics Exposure

Ju Bin Yoon, Sungmin Hwang, Jun Hyeok Yang, Seungki Lee, Woo Young Bang, Ki Hwan Moon

Subject: Life Sciences, Microbiology Keywords: Ricefish; Microbiome; Ampicillin; Erythromycin; Immune and Stress-Related Genes

Online: 29 June 2022 (03:05:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0068.v1

Strategy Development of Information Technology–Related Services Using Tows Matrix Analysis: A Case of Neust San Isidro Campus

Emmanuel C. Navarro, Jennilyn C. Mina, Romeo B. Campos, Jr.

Subject: Social Sciences, Accounting Keywords: IT related services; strategy development; SWOT; TOWS Matrix Analysis

Online: 2 December 2020 (15:25:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0122.v1

Attention Modulates Electrophysiological Responses to Simultaneous Music and Language Syntax Processing

Daniel J Lee, Harim Jung, Psyche Loui

Subject: Behavioral Sciences, Cognitive & Experimental Psychology Keywords: music; language; syntax; attention; comprehension; electroencephalography; event-related potentials

Online: 13 June 2019 (13:13:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0132.v1

What Do We Know Now about IgE-Mediated Wheat Allergy in Children?

Grażyna Czaja-Bulsa, Michał Bulsa

Subject: Medicine & Pharmacology, Allergology Keywords: wheat allergy; specific immunoglobulin E; children; gluten-related disorders

Online: 28 December 2016 (10:37:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine & Pharmacology, General Medical Research Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0278.v1

Association between Knowledge about Anemia, Food Consumption Behaviors, and Hematocrit Level among School-Age Children in Nakhon Si Thammarat Province, Thailand

Pastraporn Kaewpawong, Kiatkamjorn Kusol, Onuma Bunkarn, Sirigran Sutthisompohn

Subject: Medicine & Pharmacology, Nursing & Health Studies Keywords: knowledge; food consumption behaviors; hematocrit level; school-age children

Online: 19 October 2022 (10:06:28 CEST)

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Anemia is a significant public health problem among children, especially school-age children because their body quickly produces red blood cells to provide sufficient blood volume with plasma expansion to maintain blood concentration. This research aimed to study the anemia situation, knowledge about anemia, food consumption behaviors, and the association between knowledge, food consumption behaviors, and hematocrit level among school-age children in primary school, in Thasala district, Nakhon Si Thammarat Province. This is a descriptive study among 408 students, Grades 4 to 6, aged 9-12 years. Research instruments included the demographic data of the children and their knowledge about anemia, food consumption behaviors, and hematocrit assessment. Data were analyzed using descriptive, Spearman’s rank correlation coefficient, and logistic regression statistics. The results revealed that 23.2% of the samples had anemia, whereas 22.22% had mild anemia and 0.98% had moderate anemia. The children knew about anemia, where the mean score was at a moderate level (Mean= 6.63; SD= 2.51) out of 10. The mean score on food consumption behaviors was in the moderate level (Mean= 17.49; SD= 3.68) out of 24. There were significantly positive correlations between the knowledge about anemia and the hematocrit level at a moderate level (r= 0.45, p< 0.001). Correlation analysis revealed moderate food consumption behaviors with the hematocrit level (r= 0.40, p< 0.001). When confirm with Logistic regression found that knowledge about anemia (OR = 9.15, 95% CI: 4.57-18.34), and food consumption behaviors (OR = 19.09, 95% CI: 9.71-37.53) were significantly associated with the hematocrit level. Conclusions: This study showed that knowledge and appropriate food consumption behaviors are associated with hematocrit levels. Enhancing knowledge about anemia and food consumption behaviors may be reduced the prevalence of anemia in school-age children. The health care providers in primary care should be encouraged children to have health education and eat sufficient food.

Preprint ARTICLE | doi:10.20944/preprints202206.0091.v1

Assessing the Effectiveness of Tobacco 21 Laws to Reduce Underage Access to Tobacco: Protocol for a Repeated Multi-Site Study

Mary Hrywna, Amanda Kong, Christopher Ackerman, Shawna Hudson, Cristine Delnevo

Subject: Social Sciences, Other Keywords: tobacco age of sale; tobacco policy; youth; young adults

Online: 7 June 2022 (03:44:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0367.v1

Differences in Citation Patterns across Areas, Article Types and Age Groups of Researchers

Marcelo Mendoza

Subject: Social Sciences, Library & Information Science Keywords: Citation patterns; Age groups of researchers; Types of publications.

Online: 17 August 2021 (15:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0434.v1

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Hye-Young Kim, Ha Young Jo, Seong Heon Kim

Subject: Medicine & Pharmacology, Pediatrics Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

Online: 20 July 2021 (09:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0729.v1

Sergey Sudakov, Elena Alekseeva, Galina Nazarova, Valentina Bashkatova

Subject: Behavioral Sciences, Applied Psychology Keywords: age; behaviour; open field; physical activity; anxiety; Wistar rat.

Online: 30 June 2021 (10:57:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0536.v1

“What a Mobility-Limited World”: Design Requirements of an Age-Friendly Playable City

Liliana Vale Costa, Ana Isabel Veloso, Michael Loizou, Sylvester Arnab, Richard Tomlins, Arun Sukumar

Subject: Social Sciences, Other Keywords: playable city; age-friendly environments; games; mobility; active ageing

Online: 23 October 2018 (10:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0111.v1

Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations

Jacqueline R. Halladay, Kaitlin C. Lenhart, Kimberly Robasky, Wendell Jones, Wayne F. Homan, Doyle M. Cummings, Crystal W. Cené, Alan L. Hinderliter, Cassandra L. Miller, Katrina E. Donahue, Beverly A. Garcia, Thomas C. Keyserling, Alice S. Ammerman, Cam Patterson, Darren A. DeWalt, Larry F. Johnston, Monte S. Willis, Jonathan C. Schisler

Subject: Medicine & Pharmacology, General Medical Research Keywords: hypertension; GWAS; precision medicine; rural population; SNP-age interaction

Online: 12 January 2018 (07:34:37 CET)

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Background: As part of the Heart Healthy Lenoir Project, we developed a practice level intervention to improve blood pressure control. The goal of this study was: i) determine if single nucleotide polymorphisms (SNPs) that associate with blood pressure variation, identified in large case-control studies, are applicable to blood pressure control in subjects from a rural population; ii) measure the association of these SNPs with subjects’ responsiveness to the hypertension intervention; and iii) identify other SNPs that may help understand patient-specific responses to an intervention. Methods and Results: We used a combination of candidate SNPs and genome-wide analyses to test associations with either baseline systolic blood pressure (SBP) or change in systolic blood pressure one year after the intervention in two genetically defined ancestral groups: African Americans (AA) or Caucasian Americans (CAU). Of the 48 candidate SNPs, 13 SNPs associated with baseline SBP in our study; however, one candidate SNP, rs592582, also associated with a change in SBP after one year. Using our study data, we identified 4 and 15 additional loci that associated with a change in SBP in the AA and CAU groups, respectively. Our analysis of gene-age interactions identified genotypes associated with SBP improvement within different age groups of our populations. Moreover, our integrative analysis identified AQP4-AS1 and PADI2 as genes whose expression levels may contribute to the pleiotropy of complex traits involved in cardiovascular health and blood pressure regulation in response to an intervention targeting hypertension. Conclusions: Identification of SNPs associated with the success of a hypertension treatment intervention suggests that genetic factors in combination with age may contribute to an individual’s success in lowering SBP. If these findings prove to be applicable to other populations, the use of this genetic variation in making patient-specific interventions may help providers with making decisions to improve patient outcomes. Further investigation is required to determine the role of this genetic variance with respect to the management of hypertension such that more precise treatment recommendations may be made in the future as part of personalized medicine.

Preprint ARTICLE | doi:10.20944/preprints201608.0133.v1

Calorie Restriction Supplemented with Fish Oil Ameliorates Abnormal Metabolic Status in Middle-Aged Obese Women: An Open-Label, Parallel-Arm, Controlled Trial

Fasty Arum Utami, Hsiu-Chuan Lee, Chien-Tien Su, Shih-Yi Huang

Subject: Medicine & Pharmacology, Nutrition Keywords: calorie restriction; PUFA; meal replacement; metabolic syndrome; middle age

Online: 13 August 2016 (03:39:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0260.v1

Evaluating the Sensitivity of Heat Wave Definitions Among North Carolina Physiographic Regions

Jagadeesh Puvvula, Azar Abadi, Kathryn Conlon, Jared Rennie, Hunter Jones, Jesse Bell

Subject: Life Sciences, Other Keywords: Heat Wave; Heat-related illness; Early heat-health warning systems

Online: 18 July 2022 (10:14:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0345.v1

Windtech – A Sensory Device for ‘Cold’ Sensation Measurements

Amir Leyli, Hassan Khawaja, Ståle Antonsen, Daniel Swart

Subject: Engineering, General Engineering Keywords: Cold Sensation; Heat Loss; Cold Related Risks; Real Feel Temperature

Online: 21 December 2021 (14:06:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0341.v1

Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus

Pilar Sanchis, Rosmeri Rivera, Regina Fortuny, Carlos Rio, Miguel Mas-Gelabert, Marta Gonzalez-Freire, Felix Grases, Luis Masmiquel

Subject: Life Sciences, Endocrinology & Metabolomics Keywords: AGEs; aortic calcification; type 2 diabetes mellitus; diabetes-related complications

Online: 21 May 2020 (09:46:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0416.v1

Menstruation Distress Is Strongly Associated with Hormone-Immune-Metabolic Biomarkers

Chutima Roomruangwong, Sunee Sirivichayakul, Andressa Keiko Matsumoto, Ana Paula Michelin, Laura de Oliveira Semeao, João Victor de Lima Pedrao, Decio S. Barbosa, Estefania G. Moreira, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: menstrual cycle-related syndrome; neuroimmunomodulation; biomarkers; inflammation; oxidative stress; antioxidants

Online: 29 March 2020 (03:22:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0133.v1

Hospital Malnutrition, A Call for Political Action: A Public Health and nutritionDay Perspective

Michael Hiesmayr, Silvia Tarantino, Sigrid Moick, Alessandro Laviano, Isabella Sulz, Mohamed Mouhieddine, Christian Schuh, Dorothee Volkert, Judit Simon, Karin Schindler

Subject: Medicine & Pharmacology, Nutrition Keywords: malnutrition; disease related malnutrition; risk factors; nutrition care; mortality; recommendations

Online: 12 November 2019 (16:46:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0107.v1

Compatibility and Stability of Daptomycin Lock Solutions in Combination with Gentamicin, Azithromycin, Heparin and Trisodium Citrate

P. Brandon Bookstaver, Padmavathy Premnath, Kayisa Wright, Campbell McInnes

Subject: Medicine & Pharmacology, Pharmacology & Toxicology Keywords: daptomycin; antibiotic lock therapy; gentamicin; azithromycin; catheter-related bloodstream infections

Online: 10 September 2019 (10:43:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0207.v1

Assessing Language-Induced Motor Activity through Event Related Potentials and the Grip Force Sensor, an Exploratory Study

Fernanda Pérez-Gay Juárez, David Labrecque, Victor Frak

Subject: Behavioral Sciences, Behavioral Neuroscience Keywords: language; motor system; event related potentials; action simulation; embodied semantics

Online: 21 January 2019 (11:03:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0409.v1

Are There Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders? A Retrospective Cross-Sectional Study

Daniela Caldirola, Tatiana Torti, Francesco Cuniberti, Silvia Daccò, Alessandra Alciati, Koen Schruers, Giovanni Martinotti, Domenico De Berardis, Giampaolo Perna

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: childhood trauma; major depressive disorder; bipolar disorder; sex difference; age

Online: 31 May 2022 (03:39:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0192.v1

Inequalities in Temporal Effects on Cervical Cancer Mortality in States in Different Geographic Regions of Brazil: An Ecological Study

Karina Cardoso Meira, Carinne Magnago, Angelo Braga Mendonça, Stephane Fernanda Soares Duarte, Pedro Henrique Oliveira de Freitas, Juliano dos Santos, Dyego Leando Bezerra de Souza, Taynãna César Simões

Subject: Medicine & Pharmacology, Obstetrics & Gynaecology Keywords: uterine cervical neoplasms; mortality; age-period-cohort analysis; forecasting; Brazil

Online: 16 February 2022 (05:03:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0506.v1

A Retrospective Cohort Study of the Clinical Features, Pathological Characteristics, and Molecular Classification in Reproductive Age Patients with Endometrial Cancer who Experienced Unsuccessful Fertility-sparing Treatment

Tong Yu, Xi-Wen Zhang, Ping-Li Sun, Abdulkarim Mohamed Farah, Yan Jia

Subject: Medicine & Pharmacology, Obstetrics & Gynaecology Keywords: endometrial cancer; fertility-sparing management; molecular classification; reproductive age; pregnancy

Online: 26 November 2021 (12:42:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0446.v1

Non-Modifiable Risk Factors (Age and Sex), Stroke Types, and Outcomes in Rivers State, Nigeria: A Retrospective Hospital-Based Study

Osborne Ikechuckwu Osuegbu, Foluke Olukemi Adeniji, Golden Chukwuemaka Owhonda, Rogers Bariture Kanee, M Alblihed, Gaber El-Saber Batiha, Eric Osamudiamwen Aigbogun

Subject: Medicine & Pharmacology, Allergology Keywords: Age; Sex; Stroke Types; Outcomes; SEM; Tertiary Hospitals; Rivers State

Online: 20 July 2021 (11:45:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0696.v1

Revealed Preferences of Fourth Graders When Requesting Face-to-Face Help While Doing Math Exercises Online

Roberto Araya, Raúl Gormaz

Subject: Social Sciences, Accounting Keywords: Help Seeking; Same-age Peer Tutoring; Revealed Preferences; Data analytics

Online: 29 June 2021 (11:36:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0392.v1

Prevalence of Controlled Systemic Hypertension and Its Associated Risk Factors among Hypertensive Patients at Mbeya Zonal Referral Hospital, Tanzania.

Samson Peter Mvandal, Victor Jastin Mwinuka

Subject: Keywords: Age; adherence; anti-hypertensive; Controlled hypertension; clinic; hypertension; Prevalence; Systemic

Online: 17 May 2021 (15:57:01 CEST)

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Working Paper REVIEW

A Systematic Review of Neuroimaging and Acute Cannabis Exposure in Age-of-Risk for Psychosis

Lani Cupo, Eric Plitman, Elisa Guma, M Mallar Chakravarty

Subject: Life Sciences, Biochemistry Keywords: systematic review; cannabis; neuroimaging; age-of-onset psychosis; psychosis; schizophrenia

Online: 14 May 2021 (09:58:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0589.v1

Compaction Model for Shale in Differences of Geological Ages Using A 3D Empirical Relationship in Northeastern Thailand

Avirut Puttiwongrak, Syukratun Nufus, Chaiyaphruk Bunprasert, Pham Huy Giao, Sakanann Vann, Thongchai Suteerasak, Nophea Sasaki

Subject: Earth Sciences, Atmospheric Science Keywords: Shale compaction; Geological age; Thailand shale; Compaction model; Standard curve

Online: 21 April 2021 (16:50:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0478.v1

Quality of Life: Changes in Self Perception in People with DS who Participate in Laliga Genuine Santander. Self Reports and External Reports

Rocío Camacho, Cristina Castejón-Riber, Francisco Requena, Julio Camacho, Arturo Gallego, Roberto Espejo, Amaranta De Miguel-Rubio, Begoña M. Escribano, Estrella I. Agüera

Subject: Behavioral Sciences, Applied Psychology Keywords: Down's Syndrome; perception; quality of life; sport; age; gender; scale

Online: 18 December 2020 (16:17:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0090.v1

Tapering, Tree Rings and Biomass Production of Pinus roxburghii (Sarg.): A Dendrochronological Study

Hari Prasad Pandey, Narayan Prasad Pokhrel

Subject: Life Sciences, Other Keywords: age; coring sample; forest productivity; Nepal; P. roxburghii; stand structure

Online: 4 September 2020 (08:08:30 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202005.0005.v1

Age-Adaptive and Gender-Balanced Social Interventions Might Be Stepping Stones to the Next ‘New Normal’ in COVID-19 Outbreak

Carlo Vittorio Cannistraci, Ilaria Capua

Subject: Life Sciences, Virology Keywords: social intervention; COVID-19; health policy; public health; age; gender

Online: 2 May 2020 (12:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0051.v3

Bulk and Single-Cell Transcriptomics Identify Tobacco-Use Disparity in Lung Gene Expression of ACE2, the Receptor of 2019-nCov

Guoshuai Cai

Subject: Life Sciences, Microbiology Keywords: Wuhan 2019-nCov; ACE2; expression; susceptibility; race; age; gender; smoking; single cell

Online: 2 March 2020 (01:38:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0380.v1

Physical Activity in Elderly Kidney Transplant Patients with Multiple Renal Arteries

Armando Calogero, Caterina Sagnelli, Gaia Peluso, Antonello Sica, Maria Candida, Silvia Campanile, Gianluca Minieri, Paola Incollingo, Massimiliano Creta, Luigi Pelosio, Vincenzo Tammaro, Alessandro Scotti, Akbar Jamshidi, Marcello Caggiano, Evangelista Sagnelli, Concetta Anna Dodaro, Nicola Carlomagno, Michele Santangelo

Subject: Medicine & Pharmacology, Urology Keywords: physical activity; kidney transplantation; elder age; vascular anomalies; marginal kidneys

Online: 29 December 2019 (11:06:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0236.v1

Growth Opportunities and Earnings Quality from Emerging Economies

Jerry Danjuma kwarbai, Rufus Ishola Akintoye, Festus Fola Adegbie, Apollos Nwabuisi Nwaobia

Subject: Social Sciences, Accounting Keywords: earnings quality; growth opportunities; discretionary accruals; corporate age; corporate size

Online: 23 August 2019 (04:40:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0260.v1

Evaluation of Questionnaire Data Views on the Design of Living Space for Different Situations in Life

Carsten Brausch, Dušan Katunský, Jana Katunská

Subject: Engineering, Civil Engineering Keywords: interior design; questionare; life situation; data evaluation; different age groups

Online: 23 April 2019 (13:12:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0241.v1

Six-year-old Ecological Concrete in a Marine Environment: a Case Study

Amit Kenny, Ela Ofer Rozovsky

Subject: Engineering, Civil Engineering Keywords: Ecological concrete; Cement/cementitious materials; Durability-related properties; Carbonation; Chloride; Diffusion

Online: 14 December 2022 (02:03:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0360.v1

The Effect of Small Particulate Matter on Tourism and Related SMEs in Chiang Mai, Thailand

Phisek Srinamphon, Sainatee Chernbumroong, Korrakot Tippayawong

Subject: Social Sciences, Business And Administrative Sciences Keywords: tourism and related; SMEs; small particulate matters; association rules; data mining

Online: 27 June 2022 (10:24:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0257.v1

Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric Practice

Paul E. Rapp, Christopher Cellucci, David Darmon, David Keyser

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: biomarkers; electroencephalography; event related potentials; heart rate variability; diagnosis; sensitivity; specificity

Online: 17 March 2022 (15:19:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0772.v1

Wing Lok Chan, Horace Cheuk-Wai Choi, Patty Pui-Ying Ho, Johnny Kin-San Lau, Rosa Pui-Ying Tse, Joyce Au, Vivian Lam, Ronald Liu, Isaac Ho, Charlotte Wong, Ben Cheung, Eric Lam, Daryn Chow, Ka-On Lam, Kwok-Keung Yuen, Dora Lai-Wan Kwong

Subject: Medicine & Pharmacology, Allergology Keywords: Immune checkpoint inhibitors; immune-related endocrine dysfunction; hypothyroidism; targeted therapy; malignancy

Online: 31 May 2021 (12:49:40 CEST)

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Abstract Background The number of immune-related endocrine dysfunctions (irEDs) has concurrently increased with the widespread use of immunotherapy in clinical practice and further expansion of the approved indications for immune checkpoint inhibitor (ICI) combinations using different modalities of anti-cancer treatment. Method A retrospective analysis was conducted on consecutive patients >18 years of age with advanced solid malignancies who had received at least one dose of anti-programmed cell death protein 1 (anti-PD-1) and/or anti-CTLA4 antibodies between January 2014 and December 2019 at a Hong Kong university hospital. Patients were reviewed for up to two months after the last administration of an ICI. The types, onset times and grades of irEDs, including hypothyroidism, hyperthyroidism, adrenal insufficiency and immune-related diabetes mellitus, were recorded. Factors associated with irEDs were identified using multivariate analysis. Result A total of 953 patients (male: 603, 64.0%; median age: 62.0 years) received ICIs during the study period. Of these, 580 patients (60.9%) used ICI-alone, 132 (13.9%) used dual-ICI, 187 (19.6%) used an ICI combined with chemotherapy (chemo+ICI), and 54 (5.70%) used immunotherapy with a targeted agent (targeted+ICI). A significantly higher proportion of patients using targeted+ICI had irEDs and hypothyroidism; in contrast, a higher proportion of patients using dual-ICI had adrenal insufficiency. There was no significant difference in the incidence of irED between the younger (<65 years) and older (>65 years) patients. Using logistic regression, only treatment type was significantly associated with irEDs. Notably, older patients had a higher risk of having immune-related diabetes mellitus. Conclusions This large, real-world cohort demonstrates that combining ICI with targeted therapy has a higher risk of overall irED and hypothyroidism. Immunotherapy is safe and well-tolerated regardless of age, but close monitoring of fasting glucose is needed in older populations.

Working Paper ARTICLE

Photothermal Killing of A549 Cells and Autophagy Induction by Bismuth Selenide Nanoparticles

Yue You, Jinxia Li, Linlin Chen, Mei Wang, Xinghua Dong, Liang Yan, Aiping Zhang, Feng Zhao

Subject: Materials Science, Biomaterials Keywords: bismuth selenide nanoparticles; photothermal killing; apoptosis; autophagy; stress-related signaling pathway

Online: 10 May 2021 (10:52:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0282.v1

The Deficit of Multimodal Perception of Congruent and Non-congruent Fearful Expressions in Patients with Schizophrenia: The ERP Study

Galina V Portnova, Aleksandra Maslennikova, Natalia Zakharova, Olga V Martynova

Subject: Behavioral Sciences, Applied Psychology Keywords: EEG; event-related potentials; schizophrenia; fearful expressions; perception; non-congruent sounds

Online: 11 December 2020 (12:58:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0243.v2

Morphological and Molecular Status of Daphne Wolongensis Brickell et Mathew as Genetic Resource for Horticulture

Vojtěch Holubec, Leona Leišová-Svobodová

Subject: Biology, Horticulture Keywords: Daphne wolongensis; distribution; morphology; relationships; genetics; AFLP; related species; Rehdera section

Online: 16 September 2020 (03:12:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0080.v1

SHERLOCK and DETECTR: CRISPR-Cas Systems as Potential Rapid Diagnostic Tools for Emerging Infectious Diseases and Cancer-Associated Mutations

Mujahed Mustafa, Abdelrafie Makhawi

Subject: Life Sciences, Biotechnology Keywords: cancer-related viruses; CRISPR-Cas diagnostic tools; DETECTR; infectious disease; SHERLOCKv2

Online: 7 April 2020 (09:43:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0009.v1

Effect of Tea Polyphenol on Serum Hormone, Serum Enzyme Activity and Antioxidant-Related Gene Expression in Chinese Yellow Chicken under Heat Stress

Minxuan Yang, Yinglin Lu, Qizhao Zhu, Peng Gao, Xiaolei Xie, Debing Yu

Subject: Biology, Animal Sciences & Zoology Keywords: tea polyphenol; serum hormone; enzyme activity; immune function, enzyme-related genes

Online: 1 August 2019 (05:18:08 CEST)

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The present study was conducted to evaluate the effects of dietary supplementation of tea polyphenol （TP） on serum hormone, serum enzyme activity, antioxidant-related and immune-related gene expression of laying hens under heat stress. A total of 288 Chinese yellow chicken (186 days old) were randomly distributed among two treatments, each of which included 6 replicates of 24 hens. Dietary treatments were that the basal diet was supplemented with 200 mg / kg tea polyphenol. The study lasted for 7 weeks, including 1 week of adaptation and 6 weeks of the formal test. The content of high-density lipoprotein cholesterol (HDL-C) and total protein (TP) in serum significantly decreased by dietary supplementation with tea polyphenol. Dietary tea polyphenol supplementation improved serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activity and decreased serum malondialdehyde (MDA) content in treatments compared to the control. However, supplementation of tea polyphenol did not affect the activity of serum catalase (CAT). The results indicated that long-term feeding of tea polyphenols help to increase the amount of hormones (FSH, E2) associated with reproduction in laying hens and thus improve egg production. It also improved the immune function of laying hens in high temperature environments. Adding tea polyphenols to the diet can significantly increase the serum IgG, IgM content of the laying hens and can upregulate the IgA content. Dietary supplementation of tea polyphenols in the laying hens significantly increased the expression of antioxidant enzyme-related genes (SOD, CAT and GPX1) in the liver. Moreover, the addition of tea polyphenols significantly increased the expression of immune-related genes (Interferon-γ (INF-γ), Interleukin 2 (IL-2) and Interleukin 4 (IL-4)) in the spleen. It is concluded that addition of tea polyphenols has a positive effect on antioxidant activity and immune function of laying hens.

Preprint ARTICLE | doi:10.20944/preprints201810.0565.v1

Aberrant Epigenetic Regulation in Head and Neck Cancer Due to Distinct EZH2 Overexpression and DNA Hypermethylation

Daiki Mochizuki, Yuki Misawa, Hideya Kawasaki, Atsushi Imai, Shiori Endo, Masato Mima, Satoshi Yamada, Takuya Nakagawa, Takeharu Kanazawa, Kiyoshi Misawa

Subject: Medicine & Pharmacology, Other Keywords: EZH2; epigenetic regulation; DZNep; tumor-related genes; head and neck cancer

Online: 24 October 2018 (10:34:10 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201810.0527.v1

Cross-Modal Priming Effect of Rhythm on Visual Word Recognition and Its Relationships to Music Aptitude and Reading Achievement

Tess S. Fotidzis, Heechun Moon, Jessica R. Steele, Cyrille L. Magne

Subject: Behavioral Sciences, Cognitive & Experimental Psychology Keywords: implicit prosody; rhythm sensitivity; event related potentials; reading achievement; musical aptitude

Online: 23 October 2018 (08:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0061.v1

Ozlem Koseoglu Ornek, Erdem Sevim

Subject: Medicine & Pharmacology, Other Keywords: Work-related stress; occupational stress; coping profile; garment workers; textile workers

Online: 7 February 2018 (10:26:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0113.v1

Cached Files Updating Revisited: The Distribution of Popularity-Weighted Average File Age

Jixiang Zhang

Subject: Engineering, Control & Systems Engineering Keywords: age of information; cached files updating; stationary distribution; discrete time model

Online: 5 September 2020 (04:22:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0383.v1

Order Effects in the Perception and Production of New Words

Peter Richtsmeier, Michelle Moore

Subject: Behavioral Sciences, Developmental Psychology Keywords: child speech; speech production; speech perception; learning; consonant age of acquisition

Online: 24 May 2020 (16:07:44 CEST)

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Purpose: Perceptual learning and production practice are basic mechanisms that children depend on to acquire adult levels of speech accuracy. In this study, we examined perceptual learning and production practice as they contributed to changes in speech accuracy in three- and four-year-old children. Our primary focus was manipulating the order of perceptual learning and baseline production practice to better understand when and how these learning mechanisms interact. Method: Sixty-five typically-developing children between the ages of three and four were included in the study. Children were asked to produce CVCCVC nonwords like /bozjəm/ and /tʌvtʃəp/ that were described as the names of make-believe animals. All children completed two separate experimental blocks: a baseline block in which participants heard each nonword once and repeated it, and a test block in which the perceptual input frequency of each nonword varied between 1 and 10. Half of the participants completed a baseline-test order; half completed a test-baseline order. Results: Greater accuracy was observed for nonwords produced in the second experimental block, reflecting a production practice effect. Perceptual learning resulted in greater accuracy during the test for nonwords that participants heard 3 or more times. However, perceptual learning did not carry over to baseline productions in the test-baseline design, suggesting that it reflects a kind of temporary priming. Finally, a post hoc analysis suggested that the size of the production practice effect depended on the age of acquisition of the consonants that comprised the nonwords. Conclusions: The study provides new details about how perceptual learning and production practice interact with each other and with phonological aspects of the nonwords, resulting in complex effects on speech accuracy and learning of form-referent pairs. These findings may ultimately help speech-language pathologists maximize their clients’ improvement in therapy.

Preprint ARTICLE | doi:10.20944/preprints201912.0379.v1

Post-Transplant Lymphoproliferative Diseases in the Elderly after Cardiac Transplantation: The Diagnostic Role of [18f] FDG-PET With Co-Registered CT and the Effect of Sports Activity Rehabilitation Program

Antonello Sica, Maria Luisa de Rimini, Beniamino Casale, Caterina Sagnelli, Alessandro Spada, Alfonso Reginelli, Armando Calogero, Cristiano Amarelli, Ciro Maiello, Evangelista Sagnelli, Maria Paola Belfiore, Salvatore Cappabianca

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: post-transplant lymphoproliferative disorder; FDG-PET/CT; elder age; physical activity

Online: 29 December 2019 (10:37:20 CET)

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