ARTICLE | doi:10.20944/preprints202012.0106.v1
Subject: Engineering, Automotive Engineering Keywords: Cauvery; hydrological modelling; VIC, SWAT; GWAVA; ensemble modelling; water resources
Online: 4 December 2020 (11:59:41 CET)
This paper presents a comparison of the predictive capability of three hydrological models in a heavily influenced catchment in Peninsula India. In catchments where there is a high dependence on both streamflow and groundwater to meet demands, it is of importance to capture the catchment processes correctly. This study highlights the performance evaluation of a multi-model ensemble consisting of GWAVA (Global Water AVailability Assessment) model, SWAT (Soil Water Assessment Tool) and VIC (Variable Infiltration Capacity) model for comparative purposes and the key catchment hydrological processes. The three models were compared in several sub-catchments in the upstream reaches of the Cauvery river catchment. Model performances for monthly streamflow simulations from 1983 – 2005 were analysed for five catchments in the Upper Cauvery. The analysis was undertaken using Nash- Sutcliffe Efficiency, Kling- Gupta Efficiency and percent bias. Additionally, a mean ensemble is presented. The application of a multi-model ensemble approach can be useful in overcoming the uncertainties associated with individual models. The ensemble mean has a better predictive ability in catchments with reservoirs than the individual models. Utilising multiple models could be a suitable methodology to offset uncertainty in input data and poor reservoir operation functionality within individual models. This study has highlighted the importance of an accurate spatial representation of precipitation for input into hydrological models and comprehensive reservoir functionality is paramount to obtaining good results in this region.
ARTICLE | doi:10.20944/preprints202105.0762.v1
Subject: Mathematics & Computer Science, Numerical Analysis & Optimization Keywords: smoke simulation; vortex method; Vortex-In-Cell (VIC)
Online: 31 May 2021 (12:11:04 CEST)
In this paper, we use three different experimental methods (particle method, grid method and hybrid method) to model and simulate the smoke from the perspective of fluid dynamics. Through the comparison of different methods, we conclude: The particle method can avoid the numerical dissipation problem caused by grid calculation, but it also brings problems such as the distortion of the trajectory of the example. The grid method is accurate in calculation, but it is prone to numerical dissipation and loss of details. Finally, we choose the hybrid method to store the vorticity in the form of particles in vortex particles, avoiding the numerical dissipation problem caused by the use of grids, and including rich turbulence, which perfectly shows the simulation effect of smoke.
REVIEW | doi:10.20944/preprints201902.0043.v1
Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: ADC; HM2-MMAE; (vic-)trastuzumab duocarmazine; Trastuzumab deruxtecan; TAK-522; Trastuzumab emtansine; anti-HER2/PBD-MA; HER2 low; HER2-low; mode of action
Online: 4 February 2019 (17:01:31 CET)
Since the discovery of the human epidermal growth factor receptor 2 (HER2) as an oncogenic driver in a subset of breast cancers and the development of HER2 directed therapies, the prognosis of HER2 amplified breast cancers has increased meaningfully. Next to monoclonal anti-HER2 antibodies and tyrosine kinase inhibitors, the antibody-drug conjugate T-DM1 is a pillar of targeted treatment of advanced HER2-positive breast cancers. Currently, several HER2 directed antibody-drug conjugates are under clinical investigation for HER2 amplified but also HER2 expressing but not amplified breast tumors. In this article, we review the current preclinical and clinical evidence of the investigational drugs A166, ALT-P7, ARX788, DHES0815A, DS-8201a, RC48, SYD985, MEDI4276 and XMT-1522.