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Preprint REVIEW | doi:10.20944/preprints202304.1112.v1

Balloon Dilatation in the Management of Congenital Obstructive Lesions of the Heart: Review of Author’s Experiences and Observations – Part II

P. Syamasundar Rao

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: pulmonary stenosis; aortic stenosis; aortic coarctation; balloon valvuloplasty; balloon angioplasty; infundibular stenosis; right ventricular filling; aortic remodeling

Online: 28 April 2023 (04:48:14 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0460.v1

Four Siblings with Osteopetrosis and Pyloric Stenosis and Three Cousins with Osteopetrosis

Fahad Mishal AL-Harbi, Elsharif A Bazie, Marwah Ali Al-Hausa, Lamyaa Al-Omar, Tasneem H Al-draye

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Osteopetrosis; Pyloric stenosis; Familial

Online: 7 July 2023 (05:10:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0209.v1

Focus on the Most Common Paucisymptomatic Vasculopathic Population, from Diagnosis to Secondary Prevention of Complications

Eugenio Martelli, Iolanda Enea, Matilde Zamboni, Massimo Federici, Umberto M. Bracale, Giuseppe Sangiorgi, Allegra R. Martelli, Teresa Messina, Alberto M. Settembrini

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: diagnosis; secondary prevention; complications; abdominal aortic aneurysm; carotid stenosis; lower extremity arterial disease; popliteal artery aneurysm; renal artery stenosis; subclavian artery stenosis

Online: 4 May 2023 (07:21:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1540.v1

Congenital Partial Colonic Agenesis in Dogs and Cats: Clinical, Biological, Diagnostic Imaging, Endoscopic and Histopathologic Characterization. A Retrospective Study of 23 Cases

Paul Remmel, Lucile Gros, Jérémy Mortier, Valérie G Freiche

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: Congenital; Colonic Agenesis; Stenosis; Canine; Feline

Online: 24 July 2023 (09:30:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0384.v2

MicroRNAs in Valvular Heart Diseases: Biological Regulators, Prognostic Markers and Therapeutical Targets

Francesco Nappi, Adelaide Iervolino, Sanjeet Singh Avtaar Singh, Massimo Chello

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: miRNAs; valvular heart diseases; aortic stenosis; calcification; mitral valve prolapse, aortic valve defect; vectors; delivery systems; nanoparticles

Online: 8 November 2021 (14:25:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0276.v1

A Novel Physiologically Based Algorithm (PBA) for Fast CFD Computation of Flow Fractional Reserve (FFR) in Coronary Artery Trees

Sholpan Sumbekova, Xiaohui Su, Yong Zhao

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: FFR; Blood Flow Simulation; SimVascular; coronal stenosis; cCTA

Online: 16 January 2023 (08:29:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0376.v1

Cervical Foraminal Changes in Patients with Intermittent Arm Radiculopathy Studied with a New MRI Compatible Compression Device

John Hutchins, Hanna Hebelka, Pär-Arne Svensson, Tor Åge Myklebust, Kerstin Lagerstrand, Helena Brisby

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Cervical spine; dynamic MRI; foraminal stenosis; kinetic MRI; Spurling test

Online: 6 September 2023 (14:31:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1588.v1

Aortic Valve Dysfunction and Aortopathy According to the Presence or Absence of Raphe in Patients with Bicuspid Aortic Valve Disease

Yu Zhang, BO Hwa Choi, Hyun Keun Chee, Jun Seok Kim, Sung Min Ko

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: bicuspid aortic valve; computed tomography; aortic regurgitation; aortic stenosis; aortopathy

Online: 24 July 2023 (10:47:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1863.v1

Update on Biomarkers Associated with Large Artery Atherosclerosis Stroke

Madalena Rosário, Ana Catarina Fonseca

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: atherosclerosis; stroke; carotid; stenosis; biomarker; plaque; lipid; inflammation; IL-6

Online: 27 June 2023 (11:00:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0550.v1

A Change in Global Sagittal Alignment after Transforaminal Epidural Steroids Injections in Lumbar Spinal Stenosis

Park Manakul, Koopong Siribumrungwong, Naphakkhanith Dhanachanvisith

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Global sagittal balance; Transforaminal epidural steroids injections; Lumbar spinal stenosis

Online: 7 June 2023 (12:10:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0127.v1

Numerical Simulation of a Model Describing Plaque Rupture Phenomena in Elastic Arteries with Bifurcated Stenosis

MUDASSAR RAZZAQ

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: inite element method; Stenosis; Bifurcation; Wall shear stress; Elastic walls

Online: 7 March 2023 (07:32:27 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202309.0091.v1

A Case of Giant Goiter Associated with Airway Stenosis Caused by Long-Term Intravenous Epoprostenol Therapy for Idiopathic Pulmonary Arterial Hypertension

Kazuto Nishiura, Kazuhiko Nakazato, Tetsuro Yokokawa, Yoshinori Suzuki, Yuta Kurosawa, Kento Wada, Takeshi Shimizu, Masayoshi Oikawa, Atsushi Kobayashi, Koichi Sugimoto, Norshalena Shakespear, Yuko Hashimoto, Yasuchika Takeishi

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: idiopathic pulmonary arterial hypertension; epoprostenol; prostaglandin I₂; giant goiter; airway stenosis

Online: 5 September 2023 (10:28:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0404.v1

Aortic valve stenosis and cancer: problems of management

Gloria Santangelo, Silvia Moscardelli, Lucia Barbieri, Andrea Faggiano, Stefano Carugo, Pompilio Faggiano

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: aortic stenosis, cancer, valve replacement, cardio-oncology, transcatheter valve implantation, radiation therapy

Online: 4 August 2023 (11:44:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2019.v1

Prognostic Impact of Guidelines-oriented Age Cut-off in Intermediate-to-low Risk Patients Undergoing Transcatheter Aortic Valve Implantation in a Large Real-world Multicenter Registry

Stefano Benenati, Francesco Gallo, Won-keun Kim, Arif A Khokhar, Tobias Zeus, Stefan Toggweiler, Roberto Galea, Federico De Marco, Antonio Mangieri, Damiano Regazzoli, Bernhard Reimers, Luis Nombela-Franco, Marco Barbanti, Ander Regueiro, Tommaso Piva, Josep Rodes-Cabau, Italo Porto, Antonio Colombo, Francesco Giannini, Alessandro Sticchi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: aortic stenosis; transcatheter aortic valve replacement; age; surgical risk; low-intermediate risk

Online: 29 May 2023 (14:36:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0201.v1

CFD Computation of Flow Fractional Reserve (FFR) in Coronary Artery Trees Using a Novel Physiologically Based Algorithm (PBA) Under 3D Steady and Pulsatile Flow Conditions

Nursultan Alzhanov, Eddie Y. K. Ng, Xiaohui Su, Yong Zhao

Subject: Biology And Life Sciences, Biophysics Keywords: FFR, Blood Flow Simulation, coronal stenosis, Coronary Computed Tomography Angiography (CCTA), OpenFOAM

Online: 11 January 2023 (11:56:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0921.v1

Atherogenic Index of Plasma Predicts Obstructive Coronary Artery Disease in Patients with Stable Angina Pectoris

Haci Ali Kurklu, Turkan Seda Tan, Nil Ozyuncu, Emir Baskovski, Cagdas Ozdol

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Atherogenic Index of Plasma; Coronary artery disease; Cardiovascular risk factor; Coronary artery stenosis

Online: 13 September 2023 (15:49:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0310.v1

Aerobic Exercise Training Improves Calcium Handling and Cardiac Function in Rats with Heart Failure Resulting from Aortic Stenosis

Vitor Loureiro Da Silva, Gustavo Augusto Ferreira Mota, Sérgio Luiz Borges De Souza, Dijon Henrique Salomé De Campos, Alexandre Barroso Melo, Danielle Fernandes Vileigas, Priscila Murucci Coelho, Paula Grippa Sant’Ana, Carlos Padovani, Ana Paula Lima-Leopoldo, Silméia Garcia Zanati Bazan, Andre Soares Leopoldo, Antonio Carlos Cicogna

Subject: Biology And Life Sciences, Life Sciences Keywords: exercise training; aortic stenosis; heart failure; isolated papillary muscle; isolated cardiomyocyte; calcium handling.

Online: 5 June 2023 (10:47:28 CEST)

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Aerobic exercise training (AET) has been used in the management of heart disease. AET may, totally or partially, restore the activity and/or expression of proteins that regulate calcium (Ca2+) handling, optimize intracellular Ca2+ flow, and attenuate cardiac functional impairment in failing hearts. However, the literature presents conflicting data regarding the effects of AET on Ca2+ transit and cardiac function in rats with heart failure resulting from aortic stenosis. The objective of this study was to evaluate the effects of AET on calcium handling and cardiac function in rats with heart failure due to aortic stenosis. Wistar rats were distributed into two groups: control (Sham; n= 61) and aortic stenosis (AoS; n= 44). After 18 weeks, the groups were redistributed into: non-exposed to exercise training (Sham, n = 28 and AoS, n = 22) and trained (Sham-ET, n = 33 and AoS-ET, n = 22) for 10 weeks. Treadmill exercise training was performed with a velocity equivalent to the lactate threshold. Echocardiogram, isolated papillary muscle, and isolated cardiomyocyte analyzed cardiac function. During isolated papillary muscle assay and isolated cardimyocyte was evaluated Ca2+. The expression of regulatory proteins of diastolic Ca2+ was analyzed via Western Blot. AET attenuated the diastolic dysfunction and benefited the systolic function. AoS-ET animals presented better response to post-rest contraction, and SERCA2a and L-type Ca2+ channels blocked than the AoS. Furthermore, AET was able to improve aspects of the mechanical function and the responsiveness of the myofilaments to the Ca2+ of the AoS-ET animals. AoS animals presented alteration in the protein expression of the SERCA2a and NCX, and AET restored SERCA2a and NCX levels near normal values. Therefore, AET increased SERCA2a activity, improved the cellular Ca2+ influx mechanism, and increased myofilament responsiveness to Ca2+, attenuating cardiac dysfunction at cellular, tissue, and chamber levels in animals with aortic stenosis and heart failure.

Preprint ARTICLE | doi:10.20944/preprints202303.0117.v1

Fluid-Structure Interaction: Numerical Analysis of Biomagnetic Flow Inhibition on a Plaque in a Stenosed Bifurcation Artery

MUDASSAR RAZZAQ

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: Bifurcation; Elastic walls; Finite element method; Stenosis; Wall shear stress; Mag-netic field

Online: 7 March 2023 (02:03:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0465.v1

New Techniques in Hemorrhoidal Disease but the Same Old Problem: Anal Stenosis

Sezai Leventoglu, Bulent Mentes, Bengi Balci, Halil Can Kebiz

Subject: Medicine And Pharmacology, Surgery Keywords: Anal stenosis; hemorrhoidectomy; diamond flap; house advancement flap; rhomboid flap; Y-V flap

Online: 29 December 2021 (12:18:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0026.v1

Computational Analysis of Haemodynamic Indices in Synthetic Atherosclerotic Coronary Netwroks

Sergey Simakov, Timur Gamilov, Philipp Kopylov, Fuyou Liang

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: 1D haemodynamics, stenosis, systole variations, coronary circulation, tachycardia, boundary conditions, FFR, CFR, iFR.

Online: 2 August 2021 (12:08:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0338.v1

Incremental Predictive Value of Longitudinal Axis Strain and Late Gadolinium Enhancement Using Standard CMR Imaging in Patients with Aortic Stenosis

Lucia Agoston-Coldea, Kunal Bheecarry, Carmen Cionca, Cristian Petra, Lelia Strimbu, Camelia Ober, Silvia Lupu, Daniela Fodor, Teodora Mocan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: severe aortic stenosis; longitudinal axis strain; late gadolinium enhancement; cardiac magnetic resonance imaging

Online: 28 December 2018 (07:12:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0046.v2

Post-decompression Disc Herniation in Minimally Invasive versus "Mini-open" Technique - A More Common Complication

Ofir Uri, Liad Alfandari, Yoram Folman, Amit Keren, William Smith, Inbar Paz, Eyal Behrbalk

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Lumbar spinal stenosis; Spinal decompression; Minimally invasive surgery; Mini-open; Disc herniation; Post-decompression; Instability

Online: 19 June 2023 (15:17:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0107.v1

Using Discrete Multiphysics Modelling to Assess the Effect of Calcification on Hemodynamic and Mechanical Deformation of Aortic Valve

Adamu Musa Mohammed, Mostapha Ariane, Alessio Alexiadis

Subject: Engineering, Control And Systems Engineering Keywords: Discrete Multiphysics Modelling; Smoothed Particle Hydrodynamics; Lattice Spring Model; Particle-base method; Aortic Valve; Calcification; Stenosis

Online: 7 April 2020 (13:33:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0559.v1

Cartilage Conduction Hearing Aids in Clinical Practice

Tadashi Nishimura, Hiroshi Hosoi, Ryota Shimokura, Tadashi Kitahara

Subject: Medicine And Pharmacology, Otolaryngology Keywords: Bone conduction; Cartilage conduction; Hearing device; Amplification; Aural atresia; Canal stenosis; Conductive hearing loss; Chronic otitis media

Online: 7 June 2023 (13:22:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0439.v1

Extracellular Matrix Components as Diagnostic Tools in Inflammatory Bowel Disease

Laura Golusda, Anja A Kühl, Britta Siegmund, Daniela Paclik

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: extracellular matrix; glycosaminoglycans; inflammatory bowel disease; ulcerative colitis; Crohn´s disease; fibrosis; stenosis; magnetic resonance imaging; elastography; histopathology

Online: 23 August 2021 (13:20:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0214.v1

Comparison of Performance of Micro-Computed Tomography (Micro-CT) and Synchrotron Radiation CT in Assessment of Coronary Stenosis Caused by Calcified Plaques

Curtise K. C. Ng, Zhonghua Sun, Shirley Jansen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: 3D printing; accuracy; calcification; cardiovascular disease; computed tomography; coronary artery disease; coronary stenosis; micro-computed tomography; plaque; synchrotron radiation

Online: 4 July 2023 (11:15:11 CEST)

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