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Preprint ARTICLE | doi:10.20944/preprints202002.0009.v1

Identification and Validation of VEGFR2 Kinase as a Target of Voacangine by a Systematic Combination of DARTS and MSI

Yonghyo Kim, Yutaka Sugihara, Tae Young Kim, Sung Min Cho, Jin Young Kim, Ju Yeon Lee, Jong Shin Yoo, Doona Song, Gyoonhee Han, Melinda Rezeli, Charlotte Welinder, Roger Appelqvist, György Marko-Varga, Ho Jeong Kwon

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: target identification; drug affinity responsive target stability (DARTS); mass spectrometry imaging (MSI); voacangine; curcumin; natural products

Online: 3 February 2020 (04:36:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0373.v1

The Hidden Story on Heterogeneous B-raf V600E Mutation Quantitative Protein Expression in Metastatic Melanoma – Association with Clinical Outcome and Tumor Phenotypes

Lazaro Hiram Betancourt, A. Marcell Szasz, Magdalena Kuras, Jimmy Rodriguez Murillo, Yutaka Sugihara, Indira Pla, Zsolt Horvath, Krzysztof Pawlowski, Melinda Rezeli, Kenichi Miharada, Jeovanis Gil, Jonatan Eriksson, Roger Appelqvist, Tasso Militois, Bo Baldetorp, Christian Ingvar, Håkan Olsson, Lotta Lundgren, Peter Horvatovich, Charlotte Welinder, Elisabet Wieslander, Ho Jeong Kwon, Johan Malm, Istvan Balazs Nemeth, Göran Jönsson, David Fenyo, Aniel Sanchez, György Marko-Varga

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malignant melanoma; BRAF V600E mutation; proteomics; mass spectrometry genetics; heterogeneity; prognosis

Online: 31 October 2019 (10:36:32 CET)

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