The use of wind energy has been developing fast over the last years. The global cumulative wind power capacity increased by 10.5% in 2019, most of which comes from onshore wind farms. One of the consequences of this continuous increase is the use of land for onshore wind farms. There are already cases worldwide where lack of well-established plans and strategies have caused delays in projects. The need for efficiently using land for wind farms will be mandatory in the short term. In this work, we present a numerical analysis to evaluate wind farm land-use. By defining the ratio between mechanical output power over an area as a parameter called land-use ratio, this work focused on comparing several cases of aligned and staggered layouts. Mechanical output power was estimated using a validated code based on Blade Element Momentum code, and the wake velocities and wake interaction effects were estimated using a validated wind turbine CFD model. In terms of output power, staggered designs are more efficient than aligned designs. However, the results showed that even though staggered designs produced higher output power, aligned farms with tight lateral spacing could be as efficient as staggered ones in terms of land-use but using fewer turbines. In summary, tightly aligned designs should be a tendency in the future towards efficient use of land in wind farms.

Therapeutic proteins are used to successfully treat hemophilia, Crohn’s Disease, diabetes, and cancer. Recent product recalls have occurred because of sub-visible particle formation resulting from the inherent instability of proteins. It has been suggested that particle formation is associated with late stage processing steps of filling, shipping, and delivery. Previous works demonstrated that cavitation might occur in therapeutic vials subjected to agitation or accidentally dropped, but that mitigation can be achieved with fluid property manipulation. The goal of this research was to (1) assess the risk of cavitation under common pharmaceutical manufacturing conditions (i.e., pipe contraction and pumps), (2) establish a simple threshold criterion for when particulate will form, and (3) suggest a series of mitigation techniques based on these thresholds. To accomplish these tasks, computational fluid dynamic simulations for a variety of pipe contraction and fluid properties were performed. The results of this research show that reducing the turbulence in a fluid system will reduce the likelihood of cavitation. Additionally, threshold bounds were created that establish a definitive transition at which cavitation will occur.