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Preprint ARTICLE | doi:10.20944/preprints202307.2124.v1

Eco-Engineering Technologies and Achievements of Landscape Water Reconstructed from Aquaculture Ponds in Shanghai

Guowei Zhang, Qian Zhang, Kankan Shang

Subject: Environmental And Earth Sciences, Ecology Keywords: wetland restoration; biodiversity; post-evaluation; ecological monitoring

Online: 1 August 2023 (03:34:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0269.v1

Occupational Stress and Burnout among Intensive Care Unit Nurses during the Pandemic: A Prospective Longitudinal Study of Nurses in COVID and non-COVID Units

Pratima Saravanan, Tariq Nisar, Qian Zhang, Faisal Masud, Farzan Sasangohar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: critical care; physiological measurement; nursing and nursing systems; naturalistic study; fatigue

Online: 15 November 2022 (03:18:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0277.v1

Exploring Potential Causal Genes for Immunoglobulin A Nephropathy: A Summary Data-Based Mendelian Randomization and FUMA Analysis

Qian Zhang, Kang Zhang, Yining Zhu, Jingyun Yang, Minmin Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: immunoglobulin A nephropathy; expression quantitative trait loci; summary data-based Mendelian randomization; genome-wide association study; functional mapping

Online: 20 May 2022 (12:13:06 CEST)

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Working Paper ARTICLE

Preparation and Characterization of Two Types of Tryptanthrin-Loaded Nanomicelles

Xin He, Qian Zhang, Youbei Qiao, Zhe Yu, Tiehong Yang, Hong Wu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: nanomicelle; polyethylene glycol; tryptanthrin; water soluble

Online: 14 November 2019 (09:46:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2067.v1

Metagenomic Insights Reveal the Microbial Diversity and Associated Algal Polysaccharide-Degrading Enzymes on the Surface of Red Algae among Remote Regions

Xiaoqian Gu, Zhe Cao, Luying Zhao, Dewi Seswita-Zilda, Qian Zhang, Liping Fu, Jiang Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Metagenomics; red algae; microbial diversity; algal-polysaccharide-degrading enzymes

Online: 30 May 2023 (07:33:37 CEST)

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Macroalgae and macroalgae-associated bacteria together constitute the most efficient metabolic cycling system in the ocean. Their interactions, especially the responses of macroalgae-associated bacteria communities to algae in different geographical locations, is mostly unknown. In this study, metagenomics was used to analyze the microbial diversity and associated algal polysaccharide-degrading enzymes on the surface of red algae among three remote regions. There were significant differences in the macroalgae-associated bacteria community composition and diversity among the different regions. At the phylum level, Proteobacteria, Bacteroidetes, and Actinobacteria had a significantly high relative abundance among the regions. From the perspective of species diversity, samples from China had the highest macroalgae-associated bacteria diversity, followed by those from Antarctica and Indonesia. In addition, in the functional prediction of the bacterial community, genes associated with amino acid metabolism, carbohydrate metabolism, energy metabolism, metabolism of cofactors and vitamins, and membrane transport had a high relative abundance. Canonical correspondence analysis and redundancy analysis of environmental factors showed that, without considering algae species and composition, pH and temperature were the main environmental factors affecting bacterial community structure. Furthermore, there were significant differences in algal polysaccharide-degrading enzymes among the regions. Samples from China and Antarctica had high abundances of algal polysaccharide-degrading enzymes, while those from Indonesia had extremely low abundances. The environmental differences between these three regions may impose a strong geographic differentiation regarding the biodiversity of algal microbiomes and their expressed enzyme genes. This work expands our knowledge of algal microbial ecology, and contributes to an in-depth study of their metabolic characteristics, ecological functions, and applications.

Preprint ARTICLE | doi:10.20944/preprints202104.0499.v1

An Adaptive Early Fault Detection Model of Induced Draft Fans Based on Multivariate State Estimation Technique

Ruijun Guo, Guobin Zhang, Qian Zhang, Lei Zhou, Haicun Yu, Meng Li, You Lv

Subject: Engineering, Automotive Engineering Keywords: fault detection; induced draft fan; multivariate state estimation technique (MSET); model update; power plant

Online: 19 April 2021 (14:36:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0405.v1

Drug Repurposing Strategies in the Discovery of Antifungal Agents

Qian Zhang, Fangyan Liu, Meng Zeng, Caiyan Xin, Jinping Zhang, Yingyu Mao, Zhangyong Song

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: drug repurposing; antifungal therapy; antifungal mechanism; clinical application; antifungal agents

Online: 18 February 2021 (10:21:38 CET)

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Working Paper ARTICLE

An Electronic Skin Readout System for Liquid Metal based Flexible Resistor Sensor Array

Huan Qian Zhang, Jee Chin Teoh, Jian Feng Wu, Longteng Yu, Rui-Heng Wang, Deleon Mark Francis, Chwee Teck Lim

Subject: Engineering, Electrical And Electronic Engineering Keywords: Resistive sensor array; measurement error; zero potential methods; liquid metal; flexible electrical skin

Online: 24 January 2020 (14:49:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0173.v1

Diffusion Analysis With High and Low Concentration Regions by Finite Difference Method, Adaptive Network-Based Fuzzy Inference System, and Bilayered Neural Network Method

Qike Shao, Sina Faizollahzadeh Ardabili, Majdi Mafarja, Hamza Turabieh, Qian Zhang, Shahab S. Band, Kwok-Wing Chau, Amir Mosavi

Subject: Engineering, Chemical Engineering Keywords: ANFIS; Bilayered neural network; diffusion phenomena; diffusion of molecules; machine learning

Online: 9 September 2021 (10:50:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0402.v1

Different Distribution of Soil Core Microbiota in two Places of Huabei Plain, Central China

Luan Wang, Qian Zhang, Hongtao Mei, Xiaohan Cui, Meijie Wang, Yu Zhu, Boyang Ji, Yongjun Wei

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Soil Core Microbiota; Countryside and Metropolis; Huabei Plain; Central China

Online: 20 January 2021 (14:35:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0855.v1

Global Profile of tRNA-Derived Small RNAs in Pathological Cardiac Hypertrophy Plasma and Identification of tRF-21-NB8PLML3E as a New Hypertrophy Suppressor

Jingyi Xu, Buyun Qian, Feng Wang, Ying Huang, Xinxin Yan, Ping Li, Qian Zhang, Yuan Li, Kangyun Sun

Subject: Biology And Life Sciences, Life Sciences Keywords: transfer RNA-derived small RNAs; pathological cardiac hypertrophy; small RNA sequencing; biomarkers

Online: 24 April 2023 (11:01:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0459.v1

SPIO-loaded Nanostructured Lipid Carriers as Liver Targeted Molecular T2-Weighted MRI Contrast Agent

Xiuliang Zhu, Chenying Lu, Zuhua Wang, Ying Chen, Liyong Jie, Qian Zhang, Wei Li, Yongzhong Du, Risheng Yu

Subject: Chemistry And Materials Science, Biomaterials Keywords: Superparamagnetic iron oxide; Magnetic resonance imaging; Solid lipid nanoparticles; Galactose; Liver-targeted

Online: 24 July 2018 (14:01:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0006.v1

Hydrochemical Characteristics and Water Quality Assessment of Surface Water at Xiahe County in Tibetan Plateau Pastoral of China

Qian Zhang, Shengli Wang, Muhammad Yousaf, Zhongren Nan, Shuixian Wang, Jianmin Ma, Depeng Wang, Fei Zang

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: surface water; Tibetan Plateau pastoral area; Xiahe County; hydrochemical characteristics; fuzzy comprehensive method; water quality

Online: 2 August 2016 (04:20:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0481.v1

Minimizing Errors in RT-PCR Detection and Quantification of SARS-CoV-2 RNA for Wastewater Surveillance

Warish Ahmed, Stuart Simpson, Paul Bertsch, Kyle Bibby, Aaron Bivins, Linda Blackall, Silvia Bofill-Mas, Albert Bosch, Joao Brandao, Phil Choi, Mark Ciesielski, Erica Donner, Nishita D'Souza, Andreas Farnleitner, Daniel Gerrity, Raul Gonzalez, John Griffith, Pradip Gyawali, Charles Haas, Kerry Hamilton, Chanditha Hapuarachchi, Valerie Harwood, Rehnuma Haque, Greg Jackson, Stuart Khan, Wesaal Khan, Masaaki Kitajima, Asja Korajkic, Giuseppina La Rosa, Blythe Layton, Erin Lipp, Sandra McLellan, Brian McMinn, Gertjan Medema, Suzanne Metcalfe, Wim Meijer, Jochen Mueller, Heather Murphy, Colleen Naughton, Rachel Noble, Sudhi Payyappat, Susan Petterson, Tarja Pitkanen, Veronica Rajal, Brandon Reyneke, Fernando Roman, Joan Rose, Marta Rusinol, Michael Sadowsky, Laura Sala-Comorera, Yin Xiang Setoh, Samendra Sherchan, Kwanrawee Sirikanchana, Wendy Smith, Joshua Steele, Rosalie Sabburg, Erin Symonds, Phong Thai, Kevin Thomas, Josh Tynan, Simon Toze, Janelle Thompson, Andy Whiteley, Judith Wong, Daisuke Sano, Stefan Wuertz, Irene Xagoraraki, Qian Zhang, Amity Zimmer-Faust, Orin Shanks

Subject: Environmental And Earth Sciences, Waste Management And Disposal Keywords: COVID-19; SARS-CoV-2; Wastewater; Surveillance; False-positive; False-negative; RT-PCR

Online: 19 April 2021 (13:08:13 CEST)

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Wastewater surveillance for pathogens using the reverse transcription-polymerase chain reaction (RT-PCR) is an effective, resource-efficient tool for gathering additional community-level public health information, including the incidence and/or prevalence and trends of coronavirus disease-19 (COVID-19). Surveillance of SARS-CoV-2 in wastewater may provide an early-warning signal of COVID-19 infections in a community. The capacity of the world’s environmental microbiology and virology laboratories for SARS-CoV-2 RNA characterization in wastewater is rapidly increasing. However, there are no standardized protocols nor harmonized quality assurance and quality control (QA/QC) procedures for SARS-CoV-2 wastewater surveillance. This paper is a technical review of factors that can lead to false-positive and -negative errors in the surveillance of SARS-CoV-2, culminating in recommendations and strategies that can be implemented to identify and mitigate these errors. Recommendations include, stringent QA/QC measures, representative sampling approaches, effective virus concentration and efficient RNA extraction, amplification inhibition assessment, inclusion of sample processing controls, and considerations for RT-PCR assay selection and data interpretation. Clear data interpretation guidelines (e.g., determination of positive and negative samples) are critical, particularly during a low incidence of SARS-CoV-2 in wastewater. Corrective and confirmatory actions must be in place for inconclusive and/or potentially significant results (e.g., initial onset or reemergence of COVID-19 in a community). It will also be prudent to perform inter-laboratory comparisons to ensure results are reliable and interpretable for ongoing and retrospective analyses. The strategies that are recommended in this review aim to improve SARS-CoV-2 characterization for wastewater surveillance applications. A silver lining of the COVID-19 pandemic is that the efficacy of wastewater surveillance was demonstrated during this global crisis. In the future, wastewater will play an important role in the surveillance of a range of other communicable diseases.

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