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Preprint REVIEW | doi:10.20944/preprints201807.0478.v1

Risk Stratification on Pheochromocytoma and Paraganglioma from Laboratory and Clinical Medicine

Noriko Kimura, Kazuhiro Takekoshi, Mitsuhide Naruse

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: pheochromocytoma; paraganglioma; GAPP; metastasis; prognosis; catecholamine; gene mutation; immunohistochemistry; pathology; diagnosis

Online: 25 July 2018 (11:41:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0441.v1

Pulmonary Vesicle and Bullae Formation in Patients With COVID-19: Experiences from Wuhan

Hexiao Tang, Li Zhang, Yanhong Wei, Changsheng Li, Bo Hu, Jinping Zhao, Nahush A Mokadam, Hua Zhu, Jun Lin, Sufang Tian, Xuefeng Zhou

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: Corona Virus Disease 2019; pulmonary vesicle; prognosis; surgical treatment

Online: 24 April 2020 (12:06:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0213.v1

Recommendations for How to Respond When the Family Is Hoping for a Miracle

John Stonestreet

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Poor prognosis; medically non-beneficial care; futility; breaking bad news; withdrawal of care; miracle; hope; goals of care; communication; health disparities; racial discrimination; ethnocultural discrimination

Online: 16 May 2019 (12:38:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0530.v1

Discovery of Simple Blood-Based Test to Predict Early Onset of Alzheimer’s Using Standard Clinical Mass Spectrometry Platforms

Simona Piccirella, Simone Cristoni, Christopher Fowler, James Doecke, Giulia Abate, Daniela Uberti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; biomarker; prognosis; P53; mass spectrometry

Online: 26 January 2021 (10:01:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0346.v1

Heart in Patients Infected with 2019 Novel Coronavirus (COVID-19)

Abdallah Fayssoil, Benjamin Davido, Hazrije Mustafic, Aurélien Dinh, Nicolas Mansencal

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: coronavirus; heart; prognosis; COVID-19; ICU

Online: 19 April 2020 (13:15:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints201903.0282.v1

Review of Current Evidence in the etiopathogenesis, epidemiology, diagnosis and management of acute pancreatitis

Samantha Varley, Kirsten Rossi, Meghan Murray, Alissa Nichole

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: pancreatitis; epidemiology; diagnosis; complications; treatment; prognosis.

Online: 29 March 2019 (12:13:17 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201809.0203.v1

Primary Female Urethral Cancer：A Case Report and Review of Literature

Yupeng Guan, Gang Yu, Qianyun Tang, Huan Zhou, Zhiming Bai

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Primary urethral cancer; Elderly female; Prognosis

Online: 11 September 2018 (15:43:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0330.v1

Detection of Rare Germline Variants in the Genomes of B Cell Neoplasms

Adrian Mosquera Orgueira, Miguel Cid Lopez, Andres Peleteiro Raindo, Jose Angel Diaz Arias, Beatriz Antelo Rodriguez, Laura Bao Perez, Natalia Alonso Vence, Angeles Bendaña Lopez, Aitor Abuin Blanco, Paula Melero Valentin, Roi Ferreiro Ferro, Carlos Aliste Santos, Maximo Francisco Fraga Martinez, Marta Sonia Gonzalez Perez, Manuel Mateo Perez Encinas, Jose Luis Bello Lopez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: germline; rare variant; cancer; lymphoid; B-cell; lymphomal; CLL; driver; prognosis

Online: 18 January 2021 (12:14:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0461.v1

Forecasting the Bladder Tumor Size and Immune Response of a Patient Over the Time Using a Dynamic Mathematical Model

Clara Burgos, Noemí García-Medina, David Martínez-Rodríguez, José-Luis Pontones, David Ramos, Rafael-J. Villanueva

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bladder cancer; dynamic model; uncertainty quantification; model calibration; cancer prognosis

Online: 31 May 2018 (08:18:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0077.v1

Impact of Sarcopenia as a Prognostic Biomarker of Bladder Cancer

Hiroshi Fukushima, Kosuke Takemura, Hiroaki Suzuki, Fumitaka Koga

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: sarcopenia; prognosis; biomarker; bladder cancer; urothelial carcinoma

Online: 3 August 2018 (16:05:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0278.v1

Propranolol Treatment is Associated with Better Survival in Cirrhotic Patients with Hepatic Encephalopathy

Pei-Chang Lee Lee, Yu-Ju Chen, Yueh-Ching Cho, Kuei-Chuan Lee, Ping-Hsien Chen, Wei-Yu Kao, Yi-Hsiang Huang, Teh-Ia Huo, Han-Chieh Lin, Ming-Chih Hou, Fa-Yauh Lee, Jaw-Ching Wu, Chien-Wei Su

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Cirrhosis; Hepatic encephalopathy; Propranolol; Prognosis

Online: 24 December 2018 (12:41:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0280.v1

Altered Spatial Composition of the Immune Cell Repertoire in the Bone Marrow Stem Cell Niche in Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia

Marcus Bauer, Christoforos Vaxevanis, Haifa Kathrin Al-Ali, Nadja Jaekel, Christin Le Hoa Naumann, Judith Schaffrath, Achim Rau, Barbara Seliger, Claudia Wickenhauser

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: MDS; immune cell repertoire; prognosis; multiplex immunohistochemistry; stem cell niche

Online: 13 September 2020 (11:51:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0197.v1

Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response

Jacqueline Donoghue, Lauren Kerr, Naomi Alexander, Sameer Greenall, Anthony Longano, Nicholas Gottardo, Rong Wang, Viviane Tabar, Timothy Adams, Paul Mischel, Terrance Johns

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: GBM, EGFR, ERBB4, prognosis, therapy

Online: 12 June 2018 (14:51:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0288.v1

Desmoplastic Small Round Cell Tumor: A Review of Main Molecular Abnormalities and Emerging Therapy

Celso Abdon Mello, Fernando Augusto Batista Campos, Tiago Goss Santos, Maria Leticia Gobo Silva, Giovana Tardin Torrezan, Felipe D´Almeida Costa, Maria Nirvana Formiga, Ulisses Nicolau, Antonio Geraldo Nascimento, Cassia Silva, Suely Nakagawa, Maria Paula Curado, Ademar Lopes, Samuel Aguiar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: desmoplastic small round cell tumor; treatment; prognosis; surgery; radiotherapy; chemotherapy; tyrosine kinase receptor; target therapy; rare disease

Online: 11 December 2020 (15:53:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0159.v1

Non-Coding RNAs: Uncharted Mediators of Thyroid Cancer Pathogenesis

Hossein Tabatabaeian, Samantha Yang Peiling, Yvonne Tay

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Thyroid carcinoma; non-coding RNA; radioactive iodine; drug resistance; prognosis

Online: 7 October 2020 (14:28:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0509.v1

GATA 3 Gene Overexpression Is A Biomarker of Adverse Prognosis for Peripheral T-Cell Lymphoma, Not Otherwise Specified and for ALK-Negative Anaplastic Large Cell Lymphoma: An Exploratory Analysis of 80 Latin American Cases of nodal PTCLs

Luís Alberto de Pádua Covas Lage, Cláudio Vinícius Brito, Débora Levy, Hebert Fabrício Culler, Samuel Campanelli Freitas Couto, Lucas Bassolli, Maria Claudia Nogueira Zerbini, Vanderson Rocha, Juliana Pereira

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nodal peripheral T-cell lymphomas; peripheral T-cell lymphoma, not otherwise specified (PTCL/NOS); ALK-negative anaplastic large-cell lymphoma (ALCL/ALK-); Angioimmunoblastic T-cell lymphoma (AITL); diagnosis; prognosis; GATA3 gene expression

Online: 29 April 2020 (12:48:00 CEST)

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Background: Nodal peripheral T-cell lymphomas (nPTCLs) encompass a heterogeneous group of mature and aggressive lymphoid malignancies, including peripheral T-cell lymphoma, not otherwise specified (PTCL/NOS), angioimmunoblastic T-cell lymphoma (AITL) and anaplastic large cell lymphoma (ALCL) ALK-positive and ALK-negative. Their differential diagnosis and prognosis are an issue in the clinical practice. Accurate biomarkers to refine the different subtypes of nPTCLs and to stratify their prognosis are essential to improve their treatment approach. The aim of this study was to test the prognostic impact of GATA3 gene expression, and its capability to discriminate the different subtypes of nPTCLs. Patients and Methods: From 2000 to 2017, 80 patients with nPTCLs were eligible for GATA3 gene expression analysis that was assessed retrospectively by quantitative real time PCR (qRT-PCR) of neoplastic biopsies in Formalin-Fixed Paraffin-Embedded samples (FFPE). Results: Median age was 49 years old (IqR 34-59), 43/80 (53.7%) were male. Median follow-up was 1.72 years. Of them, 36.3% were classified as PTCL/NOS, 31.2% ALK-negative ALCL, 21.2% ALK-positive ALCL and 11.3% AITL. The majority of cases had advanced stage (III/IV). Two-year estimated overall survival (OS) and progression-free survival (PFS) were 52.2% and 39.5%, respectively. The median GATA3 gene expression level was 0.49% (range 0 – 7.07) in all cohort, it was 0.11% for ALK-positive ALCL, 0.46% for ALK-negative ALCL, 0.86% for PTCL/NOS and 0.67% for AITL. The difference of GATA3 gene expression among distinct variants of nPTCLs was statistically significant (p < 0.001). GATA3 gene expression levels ≥ 0.71% discriminate PTCL/NOS from ALK-negative ALCL and AITL with sensitivity of 62% and specificity of 80.3%. GATA3 gene expression levels ≥ median was associated with poor 2-year OS for PTCL/NOS (46.7% x 21.4%, p=0.04) and for ALK-negative ALCL (85.7% x 54.5%, p=0.04). Conclusion: Despite the relative small and heterogeneous group of patients with nPTCLs, GATA3 gene overexpression may be an important biomarker associated with poor prognosis in PTCL/NOS and ALK-negative ALCL. Moreover it may also discriminate different subtypes of nPTCLs. Further studies with larger series of patients should confirm our findings.

Preprint ARTICLE | doi:10.20944/preprints202102.0059.v1

Development and Validation of a Prediction Model for 28-Day in-Hospital Mortality in Critically Ill Patients with COVID-19

Paloma Ferrando-Vivas, Doug Gould, James Doidge, Karen Thomas, Paul Mouncey, Manu Shankar-Hari, Duncan Young, Kathryn Rowan, David Harrison

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; Critical Illness; Hospital Mortality; Intensive Care Units; Outcome Assessment, Health Care; Prognosis; Risk Adjustment; Severe acute respiratory syndrome coronavirus 2

Online: 1 February 2021 (15:51:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0455.v1

Major Prosthetic Factors Influencing the Prognosis of Implant Prosthodontics. A Systematic Review.

Javier Montero

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Prognosis; prosthodontics; dental implant; clinical performance; risk factor.

Online: 18 December 2020 (11:34:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0242.v1

Characteristics and Prognosis of COVID-19 in Patients with COPD

Desirée Graziani, Joan B Soriano, Carlos Del Rio-Bermudez, Diego Morena, Teresa Díaz, María Castillo, Miguel Alonso, Julio Ancochea, José Luis Izquierdo

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COPD; COVID-19; prevalence; prognosis

Online: 11 September 2020 (05:47:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0289.v1

Environmental Impact of Subsidy Concepts to Stimulate Car Sales in Germany

Malte Scharf, Ludger Heide, Alexander Grahle, Anne Syré, Dietmar Göhlich

Subject: Engineering, Automotive Engineering Keywords: subsidy; automotive industry; prognosis; COVID-19; environmental impact; life cycle analysis

Online: 10 November 2020 (08:20:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0484.v1

Expression of Intestinal Stem Cell and Cancer Stem Cell Markers in Submucosal Invasion and Its Prognostic Significance in Gastric Cancers

Hye Sung Kim, Hyun Joo Song, In Ho Jeong, Bo Gun Jang

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Gastric cancer; Submucosal invasion; Intestinal stem cell; Cancer stem cell; Prognosis

Online: 21 July 2020 (12:34:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0064.v1

The Expression of RN7SL494P (7SL) Predicts Nodal Metastasis and Prognosis in Lung Adenocarcinoma

Xiao Zhu, Yongmei Huang, Hui Luo, Ying Xu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TCGA; lung adenocarcinoma; RN7SL494P; nodal metastasis; prognosis

Online: 5 March 2019 (12:27:55 CET)

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The metastasis of lung cancer can spread to the lymph nodes around the lungs. Metastasis, rather than the primary cancer, judges patients survival. Wherefore, a more detailed study on transcriptome of metastatic lung adenocarcinoma including primary carcinoma was carried out. LUAD RNA-seq data and the corresponding clinical information were available from The Cancer Genome Atlas (TCGA), which included 522 cases but only 515 cases have transcriptome data. Differential expression analyses between cases and controls, between primary cancer and metastasis subgroup, or between TNM stages, were respectively carried out using edgeR package. Then, the Kruskal-Wallis tests were used to verify the gradient changes of cancer metastasis or staging with the differential expression genes. The survival analyses were calculated using the Kaplan-Meier algorithm and log-rank test. The functional predictions for the differentially expressed genes were porformed with the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (GO/KEGG). Single gene set enrichment analysis (single GSEA) was run to explore the biological pathways associated with the expressions of RN7SL494P gene based on the Molecular Signatures Database (MSigDB). 406 and 439 differentially expressed genes were identified respectively in lymph node metastasis or TNM stages. 112/296 intersection genes were associated with nodal metastasis and/or staging, among them only 25 genes were associated with the nodal metastasis, 13 genes were associated with the staging with gradient changes. Only one gene (RN7SL494P) was found to be associated with prognosis. But RN7SL494P was not found joining any biological functions or processes or cellular components with GO/KEGG analyses. Finally, single GSEA enrichment and pathway analyses showed that RN7SL494P might be involving in cancer development process and poor outcome in lung adenocarcinoma. These findings highlight the potential applications of RN7SL494P as a promising molecular predictor not only in nodal metastasis but prognosis evalution in lung adenocarcinoma patients.

Preprint ARTICLE | doi:10.20944/preprints202103.0658.v1

Profiling of Matched Adipose and Skeletal Muscle in Human Pancreatic Cancer Cachexia Reveals Distinct Gene Profiles with Convergent Pathways

Ashok Narasimhan, Xiaoling Zhong, Ernie Au, Eugene P. Ceppa, Atilla Nakeeb, Michael G. House, Nicholas J. Zyromski, C. Max Schmidt, Katharyn N.H. Schloss, Daniel E.I. Schloss, Yunlong Liu, Guanglong Jiang, Bradley A. Hancock, Milan Radovich, Joshua K. Kays, Safi Shahda, Marion E. Couch, Leonidas G. Koniaris, Teresa A. Zimmers

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pancreatic cancer; RNAseq; Humans; Weight loss; Prognosis; Rectus Abdominis; Carcinoma, Pancreatic Ductal; Adipose Tissue; Pancreatic Carcinoma; Pancreatic Neoplasms; Subcutaneous Fat; High-Throughput Nucleotide Sequencing; Body Composition; Muscles; Cachexia; Muscular Atrophy; Gene Expression

Online: 26 March 2021 (11:24:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0718.v1

Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children

D M Kamrul Hasan, Shafayat Hossain Evan, Md Rezaul Karim, Xin Yi Men, Zhang Huifeng, Chen Yuan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Sepsis, Septic shock, Lactic acid, Dynamic monitoring, Prognosis

Online: 30 July 2020 (11:23:48 CEST)

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Objectives: To investigate the value of early lactate dynamic monitoring index in predicting prognosis of patients with sepsis and septic shock. Methods: We performed our test on 50 patients. Out of 50 patients, 28 are male, and 22 are female. Prospectively studied pediatric patients with septic shock were performed. Vital signs, Lactate clearance, were obtained at presentation 6 h, 12 h, 24 h over the first 48 h of hospitalization. The therapy received, outcome parameters of mortality and duration of hospitalization were recorded. Results: The statistical data and comparative analysis showed that an average of 16.88 days after admission, 5 patients have died, 17 patients are poorly prognosis leaves the hospital, and the remaining 28 are recovered and discharged. The primary outcome variable of mean 16 days hospitalization mortality rate was 10%. Poor prognosis 34% and fully recovery 56 % were observed. In this retrospective cohort study, a lactate level of more than 2.5mmol/L was the best threshold to predict 28-day mortality among severe sepsis and septic shock patients. In our research, we found mean LC 6 h 3.08mmol/L, and after 48 h mean it is 1.79mmol/L. Significant LC 6 h found, which is 8.08mmol/L in the death group patient where 48 h mmol/L shows significant high. Poor prognosis also presents a clinical increase of lactate level high in the LC 6 h analysis, which is 3.32mmol/L. Recovered patients showed a significant improvement after administering treatment depending on the patient organ involvement and good decrease of lactate reports achieved, which is 1.20mmol/L, where admission reports show it was 1.91mmol/L in LC 6 h. Mean Heart rate 94/51mmhg, pulse 119, temperature 39℃, respiratory rate 32.26, and urine output 456 ml recorded during our study. Death patient shows a remarkable detonation of those reports but has a significant clinical report with the recovered patients. Conclusion: The early lactate dynamic monitoring index has a high value in predicting sepsis and septic shock patients' prognosis, thus worth popularizing.

Working Paper ARTICLE

Distribution of Symptoms, Comorbidities, and Severity Among Patients with COVID-19 by Age Groups, Countries, and Stages of Outbreak: A Systematic Review and Meta-Analysis

Kuan-Fu Chen, Ismaeel Yunusa, Su-Hsun Liu, Chin‐Chieh Wu, Chun‐Fu Yeh, Shih-Tsung Han, Chih-Yang Mao, Dasari Harika, Richard Rothman, Andrew Pekosz

Subject: Computer Science And Mathematics, Probability And Statistics Keywords: COVID-19; sensitivity; specificity; diagnosis; prognosis

Online: 15 January 2021 (12:44:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202011.0569.v1

Quantitative Imaging and Radiomics in Multiple Myeloma: opportunity or hype?

Alberto Stefano Tagliafico, Alida Dominietto, Liliana Belgioia, Cristina Campi, Daniela Schenone, Michele Piana

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: multiple myeloma; computed tomography; artificial intelligence; radiomics; prognosis; imaging; diagnosis

Online: 23 November 2020 (09:17:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0238.v1

Tumoral HLA Class I and APM Expression and Its Effect on Intratumoral T-cell Reaction and Outcome in HPV-Negative Oral Squamous Cell Carcinoma

Claudia Wickenhauser, Daniel Bethmann, Matthias Kappler, Alexander Walter Eckert, André Steven, Juergen Bukur, Bernard A. Fox, Jana Beer, Barbara Seliger

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oral squamous cell carcinoma; HLA class I; antigen processing machinery; immune cell infiltration; immune escape; prognosis

Online: 10 September 2020 (11:37:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0221.v1

Does Giant Cell Glioblastoma Have a Better Prognosis in Comparison to Glioblastoma Multiform? A Secondary Analysis of the SEER Database from 1985–2014

Amro K. Bin Abdulrahman, Yousef R. Bukhari, Abdulaziz M. Faqihi, Khalid A. Bin Abdulrahman, Juan Gabriel Ruiz

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: brain cancer; glioblastoma multiforme; giant cell glioblastoma; prognosis

Online: 17 May 2019 (08:40:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0109.v1

Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis

Trond Aasen, Irene Sansano, Maria Ángeles Montero, Cleofé Romagosa, Jordi Temprana-Salvador, Alexandre Martínez-Marti, Teresa Moliné, Javier Hernández-Losa, Santiago Ramón y Cajal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: connexins; Cx43; gap junctions; lung cancer; immunohistochemistry; prognosis; nuclear

Online: 13 February 2019 (10:30:49 CET)

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Direct intercellular communication, mediated by gap junctions formed by the connexin transmembrane protein family, is frequently dysregulated in cancer. Connexins have been described as tumour suppressors, but emerging evidence suggests that they can also act as tumour promoters. This feature is connexin- and tissue-specific and may be mediated by complex signalling pathways through gap junctions or hemichannels or by completely junction-independent events. Lung cancer is the number one cancer in terms of mortality worldwide, and novel biomarkers and therapeutic targets are urgently needed. Our objective was to gain a better understanding of connexins in this setting. We used several in silico tools to analyse TCGA data in order to compare connexin mRNA expression between healthy lung tissue and lung tumours and correlated these results with gene methylation patterns. Using Kaplan-Meier plotter tools, we analysed a microarray dataset and an RNA-seq dataset of non-small cell lung tumours in order to correlate connexin expression with patient prognosis. We found that connexin mRNA expression is frequently either upregulated or downregulated in lung tumours. This correlated with both good and poor prognosis (overall survival) in a clear connexin isoform-dependent manner. These associations were strongly influenced by the histological subtype (adenocarcinoma versus squamous cell carcinoma). We present an overview of all connexins but particularly focus on four isoforms implicated in lung cancer: Cx26, Cx30.3, Cx32 and Cx43. We further analysed the protein expression and localization of Cx43 in a series of 72 human lung tumours. We identified a subset of tumours that exhibited a unique strong nuclear Cx43 expression pattern that predicted worse overall survival (p=0.014). Upon sub-stratification, the prognostic value remained highly significant in the adenocarcinoma subtype (p=0.002) but not in the squamous carcinoma subtype (p=0.578). This finding highlights the importance of analysis of connexin expression at the protein level, particularly the subcellular localization. Elucidation of the underlying pathways regulating Cx43 localization may provide for novel therapeutic opportunities.

Preprint ARTICLE | doi:10.20944/preprints202101.0303.v1

Controlling Nutritional Status (CONUT) Score is a Prognostic Indicator for Patients with Hemorrhagic Stroke: Results from a 3-month Follow-up Study

Bei-lei Zhu, Yan-zhi Wu, Zhong-ming Cai, Cheng-wei Liao, Le-qiu Sun, Zhi-peng Liu, Hao-man Chen, Xue-rong Huang, Ren-qian Feng, Sheng-lie Ye, Qun-li Lin, Xu-dong Zhou, Man-man Zhang, Bo Yang

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Controlling Nutritional Status Score; Hemorrhagic stroke; Nutrition screening; Prognosis; Modified Rankin Scale

Online: 15 January 2021 (16:08:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0185.v1

Prognostic Value of the Six-Minute Walk Test in Heart Failure

Vinicius Astolpho, Roberto Barbosa, Gabriela Devens, Leticia Louzada, Pietro Lima, Rodolfo Sylvestre, Renato Serpa, Osmar Calil, Luiz Fernando Barbosa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: heart failure; 6-minute walk test; prognosis

Online: 4 November 2020 (10:08:38 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0454.v1

Biomarkers for Predicting Clinical Outcomes of Chemoradiation-Based Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer

Fumitaka Koga, Kosuke Takemura, Hiroshi Fukushima

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: biomarker; chemoradiation; prognosis; bladder preservation; bladder neoplasm; urothelial carcinoma

Online: 27 August 2018 (11:13:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0154.v1

Advances in Prognostic Methylation Biomarkers for Prostate Cancer

Dilys Lam, Susan Clark, Clare Stirzaker, Ruth Pidsley

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA methylation; epigenetics; biomarkers; circulating DNA; cfDNA; prostate cancer; early detection; prognosis

Online: 7 October 2020 (09:27:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0258.v1

An Integrated Pan-Cancer Analysis and Structure-Based Virtual Screening of GPR15

Yanjing Wang, Xiangeng Wang, Yi Xiong, Cheng‐Dong Li, Qin Xu, Lu Shen, Aman Chandra Kaushik, Dong-Qing Wei

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: GPR15, pan-cancer, TCGA, cancer immunity, differential gene expression, prognosis, virtual screening

Online: 23 July 2019 (11:15:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0109.v1

Should Tumor Infiltrating Lymphocyes, Androgen Receptor, and FOXA1 expression predict Clinical Outcome in Triple Negative Breast Cancer Patients?

Anita Mangia, Concetta Saponaro, Alessandro Vagheggini, Giuseppina Opinto, Matteo Centonze, Chiara Vicenti, Ondina Popescu, Maria Irene Pastena, Francesco Giotta, Nicola Silvestris

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: TILs; TNBC; AR; FOXA1; Prognosis

Online: 8 August 2019 (12:28:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0155.v1

Prognostic Significance of EIF4G1 in Patients with Pancreatic Ductal Adenocarcinoma

Tae Sik Goh, Mihyang Ha, Jung Sub Lee, Dae Cheon Jeong, Eun Sang Jung, Myoung-Eun Han, Yun Hak Kim, Sae-Ock Oh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: EIF4GI; pancreatic ductal adenocarcinoma; prognosis; GEO; TCGA

Online: 16 January 2019 (07:54:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0476.v1

Exhaustive Capture of Ovarian Cancer Transcriptional and Genomic Variant Integrating Canonical and Mapping-Free Protocols

Zhiqin Fu, Chao Lu, Chao Ding, Chengxi Zhou, Tingting Yu, Yue Yang, Liang Shi

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Ovarian cancer; mapping-based; mapping-free; SNVs; survival prognosis

Online: 18 December 2020 (15:15:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0235.v1

Impact of Gross Strap Muscle Invasion on Outcome of Differentiated Thyroid Cancer: Systematic Review and Meta-Analysis

Li Zhang, Jia Liu, Peisong Wang, Shuai Xue, Jie Li, Guang Chen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: strap muscle invasion; prognosis; differentiated thyroid carcinoma; meta-analysis; review

Online: 14 May 2020 (11:35:41 CEST)

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Gross strap muscle invasion (gSMI) in patients with differentiated thyroid cancer (DTC) was defined as high-risk recurrent group in the 2015 American Thyroid Association guidelines. However, controversy persists because several studies suggested gSMI had little effect on disease outcome. Herein, a systematic review and meta-analysis was conducted to investigate impact of gSMI on outcome of DTC. Methods: A systematic search of electronic databases (PubMed, EMBASE, Cochrane Library, and MEDLINE) for studies published until February 2020 was performed. Case-control studies and randomized controlled trials that studied the impact of gSMI on outcome of DTC were included. Results: Six studies (all retrospective studies) involving 13639 patients met final inclusion criteria. Compared with no extrathyroidal extension (ETE), patients with gSMI were associated with increased risk of recurrence (P=0.0004,OR, 1.46; 95% CI: 1.18 to 1.80) and lymph node metastasis (LNM) (P<0.00001,OR 4.19;95% CI. 2.53 to 6.96). For mortality (P=0.34,OR 1.47;95% CI:0.67 to 3.25), ten-year disease-specific survival (P=0.80, OR 0.91;95% CI:0.44 to 1.88) and distant metastasis (DM) (P=0.21, OR 2.94;95% CI. 0.54 to 15.93), there was no significant difference between gSMI and no ETE group. In contrast with maximal ETE, patients with gSMI were associated with decreased risk of recurrence (P<0.0001,OR, 0.58; 95% CI: 0.44 to 0.76) , mortality (P=0.0003,OR 0.20;95% CI:0.08 to 0.48), LNM (P=0.0003,OR 0.64;95% CI. 0.50 to 0.81) and DM (P=0.0009,OR 0.28;95% CI. 0.13 to 0.59). Conclusions: DTC patients with gSMI had a higher risk of recurrence and LNM than those without ETE. However, in contrast with maximal ETE, a much better prognosis was observed in DTC patients with only gSMI. The findings of our meta-analysis provide supportive evidence for the validity of the T category changes in the 8th edition American Joint Committee on Cancer system. The actual impact of gSMI should be re-evaluated and revised in the recurrent risk stratification system in the future.

Preprint ARTICLE | doi:10.20944/preprints202010.0466.v1

Relationship between Dietary Fiber Intake and the Prognosis of Amyotrophic Lateral Sclerosis

Haelim Yu, Seung Hyun Kim, Min-Young Noh, Sang-Gon Lee, Yongsoon Park

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Amyotrophic lateral sclerosis; dietary fiber; gut microbiota; prognosis; vegetable fiber

Online: 22 October 2020 (21:26:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0003.v1

Prognostic Impact of Acute Kidney Injury on Decompensated Heart Failure

Layane Batista, Roberto Barbosa, Caroline Carrera, Gabriella Curcio, Pietro Lima, Vinicius Astolpho, Rodolfo Sylvestre, Lucas De Barros, Renato Serpa, Osmar Calil, Luiz Fernando Barbosa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Heart Failure; Acute Kidney Injury; Prognosis; Mortality.

Online: 2 November 2020 (08:09:49 CET)

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Introduction: Decompensated heart failure (HF) is a complex and debilitating syndrome, which constitutes a severe emergency condition with high morbidity and mortality. The kidneys play fundamental roles in the pathophysiology of HF and, in the context of decompensations, acute kidney injury (AKI) has a bilateral cause-and-effect relationship, which can significantly worsen prognosis. However, the interaction between AKI and decompensated HF is poorly understood. Objective: This study aimed to assess the occurrence of AKI in patients hospitalized due to decompensated HF and to analyze its prognostic impact during hospitalization. Methods: Prospective single-center observational study that included patients hospitalized due to decompensated HF in a tertiary-level teaching hospital, conducted between July 2017 and January 2020. Patients who developed AKI during hospitalization were compared with those who did not develop it, until hospital discharge or death. AKI was defined as a serum creatinine increase greater than or equal to 0.3 mg/dl in 48 hours, a 1.5-fold increase in baseline creatinine in seven days or urinary volume <0.5 ml/kg/h during six hours, according to the Acute Kidney Injury Network (AKIN) criteria. The endpoints analyzed were death, need for invasive mechanical ventilation (IMV) and length of hospital stay. The Wilcoxon, Mann-Whitney and unpaired student t tests were used. Results: Ninety-nine patients were included, with a mean age of 65.4 ± 14 years, of which 47 (47.5%) were male and 52 (52.5%) were female. Reduced ejection fraction was observed in 77.8% of patients, whilst 22.2% had a diagnosis of HF with preserved EF. The decompensation clinical classifications were: dry and warm = 7 (7.1%), wet and warm = 72 (72.7%), wet and cold = 15 (15.1%) and dry and cold = 5 (5.1%). The average left ventricular ejection fraction was 38.3% ± 15. AKI ocurred in 22 patients (22.2%). Comparison between patients who evolved with and without AKI showed higher mortality (36.4% vs 10.4%, p = 0.004) and the need for IMV (54.5% vs 13%, p = 0.0001) in the first group. There was no significant difference regarding the length of in-hospital stay (22.9 ± 19 vs 18.8 ± 16 days, p = 0.26). Conclusions: The occurrence of AKI was frequent in patients with decompensated HF requiring hospitalization, affecting approximately one out of five patients. This complication was significantly associated with increased mortality and the need for IMV during hospitalization.

Preprint ARTICLE | doi:10.20944/preprints202111.0096.v1

ColoSTEM Dx Kit: Innovative Alliance of Cancer Stem Cells and Glycosylation for Earlier Prediction of Colon Cancer Aggressiveness and Prognosis

Sabrina Blondy, Stéphanie Durand, Aurélie Lacroix, Niki Christou, Charline Bouchaud, Maud Peyny, Serge Battu, Alain Chaunavel, Vincent Carre, Marie-Odile Jauberteau, Fabrice Lalloue, Muriel Mathonnet

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Aggressiveness; biomarker; cancer stem cells; diagnosis; colon cancer; glycan; immunohistochemistry; lectin; prognosis

Online: 4 November 2021 (09:23:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0711.v1

A Novel Approach for Early detection of Alzheimer's disease Based on Multi Level Fuzzy Neural Networks

Hamid Akramifard, MohammadAli Balafar, SeyedNaser Razavi, Abd Rahman Ramli

Subject: Social Sciences, Psychology Keywords: Alzheimer's disease; classification; early detection; Multi-Level Fuzzy Neural Networks; prognosis

Online: 29 March 2021 (17:09:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0729.v1

Prognostic Significance of CKS2 and CD47 Expression in Patients With Gastric Cancer Who Underwent Radical Gastrectomy

Yang zhou, Jing zeng, Haoran zhuang, wei zhou, keyan wu, weigan shen

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gastric cancer; Cyclin-dependent protein kinase; Cluster of differentiation (CD) 47; Prognosis

Online: 31 May 2021 (10:13:20 CEST)

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Objective: To investigate the protein expression levels of cyclin‑dependent kinase subunit 2 (CKS2) and cluster of differentiation (CD) 47 in gastric cancer (GC) and their clinical significances. Methods: A total of 126 GC patients who underwent radical resection were selected as study subjects. Additionally, 32 patients with benign gastric tumor, 42 patients with low-grade intraepithelial neoplasia (LGIEN), and 49 patients with high-grade intraepithelial neoplasia (HGIEN) who underwent surgery were selected as the control groups. Immunohistochemistry was used to detect the expression of CKS2 and CD47 in surgical specimens. We statistically analyzed the clinical significance of the expression of the two factors. Results: (1) The positivity rates for CKS2 in benign gastric tumor tissue, LGIEN tissue, HGIEN tissue, and GC tissue gradually increased, i.e., 6.3% (2/32), 30.9% (13/42), 38.8% (19/49), and 60.3% (76/126), respectively, and the positivity rates for CD47 were 18.8% (6/32), 38.1% (16/42), 46.9% (23/49), and 65.9% (83/126), respectively. (2) High expression of CKS2 and CD47 were associated with tumor diameter, Lauren classification, number of lymph node metastases, and TNM stage. In addition, the immunohistochemical scores for CKS2 and CD47 were positively correlated (r=0.625, P=0.000). (3) The median follow-up time of 126 patients was 46.5 months, and the overall survival rate was 40.5% (51/126). Survival analysis showed that compared with that in the CKS2 (-) group, the overall survival rate for patients in the CKS2 (+) group was significantly worse (25.0% vs 64.0%, 2=15.67, P=0.000) and that compared with the CD47 (-) group, the CD47 (+) group had significantly worse overall survival (30.1% vs 60.5%, 2=15.67, P=0.000). (4) The overall survival rates of CKS2(+)CD47(+) group, CKS2(+)CD47(-) group, CKS2(-)CD47(+) group, and CKS2 (-)CD47 (-) group were 20.0%(13/65), 58.3%(7/12), 57.1%(8/14), 65.7% (23/35), respectively, the prognosis of patients in CKS2(+)CD47(+) group was significantly poor. Conclusion: High expression levels of CKS2 and CD47 were closely related to the occurrence of GC and can be used as independent risk factors to assess the prognosis of patients.

Preprint ARTICLE | doi:10.20944/preprints201910.0373.v1

The Hidden Story on Heterogeneous B-raf V600E Mutation Quantitative Protein Expression in Metastatic Melanoma – Association with Clinical Outcome and Tumor Phenotypes

Lazaro Hiram Betancourt, A. Marcell Szasz, Magdalena Kuras, Jimmy Rodriguez Murillo, Yutaka Sugihara, Indira Pla, Zsolt Horvath, Krzysztof Pawlowski, Melinda Rezeli, Kenichi Miharada, Jeovanis Gil, Jonatan Eriksson, Roger Appelqvist, Tasso Militois, Bo Baldetorp, Christian Ingvar, Håkan Olsson, Lotta Lundgren, Peter Horvatovich, Charlotte Welinder, Elisabet Wieslander, Ho Jeong Kwon, Johan Malm, Istvan Balazs Nemeth, Göran Jönsson, David Fenyo, Aniel Sanchez, György Marko-Varga

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: malignant melanoma; BRAF V600E mutation; proteomics; mass spectrometry genetics; heterogeneity; prognosis

Online: 31 October 2019 (10:36:32 CET)

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Working Paper REVIEW

An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link

Iris Grosjean, Barnabé Roméo, Marie-Angela Domdom, Nathalie Yazbeck, Grégoire D’Andréa, Amine Belaid, Olivier Camuzard, Olivia Vidal, Guillemette Crépeaux, Romain K. Gherardi, François Jerome Authier, Jean Daniel Masson, Eric Gilson, Charles Hugo Marquette, Sylvie Leroy, Jérémie Roux, Patrick Brest, Martin Von Bergen, Gérard Milano, Daniel J. Klionsky, Paul Hofman, Baharia Mograbi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: air pollutants/exposomics; autoimmunity; autophagy; cancers; COPD; environmental diseases; eQTL; infection; inflammatory; polymorphism; prognosis; risk; susceptibility; theragnosis

Online: 4 June 2020 (06:20:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0242.v1

The landscape of PDK1 in Breast Cancer

Na Wang, Jianjiang Fu, Zhihua Li, Ningni Jiang, Yanhong Chen, Juan Peng

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: PDK1; breast cancer; survival; prognosis; targeted therapy

Online: 14 September 2021 (14:51:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0513.v1

Liquid Biopsies in Epilepsy: Biomarkers for Etiology, Diagnosis, Prognosis, and Therapeutics

Jordan H. Whitlock, Tabea M. Soelter, Avery S. Williams, Andrew A. Hardigan, Brittany N. Lasseigne

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: liquid biopsy; epilepsy; circulating biomarkers; cfDNA; lncRNA; tRNA; miRNA; diagnosis; prognosis; therapeutics

Online: 26 August 2021 (16:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0527.v1

Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries

In Woong Han, Jangho Park, Eun Young Park, So Jeong Yoon, Gang Jin, Dae Wook Hwang, Kuirong Jiang, Wooil Kwon, Xuefeng Xu, Jin Seok Heo, Delinag Fu, Woo-Jung Lee, Xueli Bai, Yoo-Seok Yoon, Yinmo Yang, Keun Soo Ahn, Chunhui Yuan, Hyeon Kook Lee, Bei Sun, Eun Kyu Park, Seung Eun Lee, Sunghwa Kang, Wen hui Lou, Sang-Jae Park

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Nonfunctioning neuroendocrine tumor of pancreas; Prognosis; Resection; Risk factors

Online: 23 July 2021 (08:07:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0069.v1

The Significance of mRNA in the Biology of Multiple Myeloma and Its Clinical Implications

Anna Puła, Paweł Robak, Damian Mikulski, Tadeusz Robak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: biology; drug resistance; gene expression profiling; mRNA; multiple myeloma; prognosis; treatment

Online: 5 October 2021 (08:20:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0063.v1

Challenging the Current Paradigm of Liquid Biopsy Through Dielectrophoresis (DEP) In Prostate Cancer

Giorgio I. Russo, Nicolò Musso, Alessandra Romano, Giuseppe Caruso, Salvatore Petralia, Luca Lanzanò, Giuseppe Broggi, Massimo Camarda

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: circulating tumor cells; dielectrophoresis; prostate cancer; detection; prognosis

Online: 6 December 2021 (12:03:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0278.v1

The Role of Diet in Prognosis among Cancer Survivors: A systematic Review and Meta-Analysis of Dietary Patterns and Diet Interventions

Carlota Castro-Espin, Antonio Agudo

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: systematic review; meta-analysis; dietary pattern; prospective cohort; randomized controlled trial; cancer prognosis; cancer survival; dietary intervention

Online: 16 December 2021 (15:06:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0074.v1

Impact of Physical Activity on Recurrence Dynamics in Early Breast Cancer Patients

Elia Biganzoli, Christine Desmedt, Romano Demicheli

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: early breast cancer; prognosis; physical activity; tumor dormancy; recurrence

Online: 2 February 2021 (08:24:31 CET)

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Several studies have suggested that pre and/or postdiagnosis physical activity can reduce the risk of recurrence in breast cancer patients, however its effect according to follow-up time has not yet been investigated. We analyzed recurrence and mortality dynamics in randomized clinical trials (RCTs) from Australia and Canada. The combined Australian RCTs evaluated, at median follow-up of 8.3 years, an 8-month pragmatic exercise intervention in 337 women with newly diagnosed breast cancer, while the Canadian RCT evaluated, at median follow-up of 7.4 years, supervised aerobic or resistance exercise during chemotherapy in 242 patients. For each RCT, the control arm consisted of patients undergoing usual care. We estimated the event dynamics by the discrete hazard function, through flexible regression of yearly conditional event probabilities with generalized additive models. In the considered RCTs, the recurrence and mortality risk of patients enrolled in the physical activity arm was stably reduced at medium/long term after five year of follow-up. In the Australian RCTs where patients were recruited by urban versus rural area, the latter group did not display benefit from physical activity. Estimated Odds Ratios (95% Confidence Intervals) for Disease Free Survival (DFS) in urban women were 0.63 (0.22-1.85); 0.27 (0.079-0.90); 0.11 (0.013-0.96) at the 3rd, 5th and 7th year of follow-up, respectively. For rural women, DFS patterns were overlapping with ORs approximating 1 at the different years of follow-up. Although not reaching statistical evidence, the estimates in the Canadian trial were in line with the results from the Australian urban women with ORs (95% CI) forDFS of 0.70 (0.33-1.50); 0.47 (0.19-1.18); 0.32 (0.077-1.29) at 3rd, 5th, 7th follow-up year, respectively. While we acknowledge that the analyzed RCTs were not designed for investigating disease recurrence over time, these results support the evidence that physical activity reduces the risk of developing medium/long-term metastases. Additional translational research is needed to clarify the mechanisms underlying these observations.

Preprint ARTICLE | doi:10.20944/preprints202107.0434.v1

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Hye-Young Kim, Ha Young Jo, Seong Heon Kim

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

Online: 20 July 2021 (09:37:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0314.v2

Clinical Perspectives of Theranostics

Shozo Okamoto, Tohru Shiga, Nagara Tamaki

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: PET; theranostics; radionuclide therapy; cancer; prognosis

Online: 22 February 2021 (07:51:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0342.v1

A Novel Anoikis-Related Gene Signature Predicts Prognosis in Patients with Low-Grade Glioma and Reveals Immune Infiltration

Songyun Zhao, Hao Chi, Wei Ji, Qisheng He, Guichuan Lai, Gaoge Peng, Xiaoyu Zhao, Chao Cheng, Weiyi Huang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: anoikis; Low-grade glioma; signature; prognosis; immune microenvironment

Online: 22 September 2022 (10:38:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0602.v1

Unusual Faces of Bladder Cancer

Claudia Manini, José I. López

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Bladder cancer; diagnosis; differential diagnosis; prognosis; histopathology; immunohistochemistry

Online: 29 October 2020 (09:25:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0144.v1

Predicting Remission among Perinatal Women with Depression in Rural Pakistan: A Prognostic Model for Task-Shared Interventions in Primary Care Settings

Ahmed Waqas, Siham Sikander, Abid Malik, Najia Atif, Eirini Karyotaki, Atif Rahman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Perinatal depression; prognosis; prognostic modeling; nomogram; Pakistan

Online: 10 May 2022 (15:40:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0179.v1

Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma

Claudia Wickenhauser, Daniel Bethmann, Matthias Kappler, Alexander Walter Eckert, André Steven, Juergen Bukur, Bernard A. Fox, Jana Beer, Barbara Seliger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: oral squamous cell carcinoma; HLA class I; antigen processing machinery; immune cell infiltration; immune escape; prognosis

Online: 11 January 2021 (10:47:25 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0328.v1

An Update on the General Features of Breast Cancer in Male Patients- a Literature Review

Sinziana Ionescu, Alin Nicolescu, Marian Marincas, Octavia Luciana Madge, Laurentiu Simion

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: male; breast; cancer; diagnosis; treatment; prognosis

Online: 24 May 2022 (09:34:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0364.v1

Expression and Signaling Pathways of Nerve Growth Factor (NGF) And Pro-NGF in Breast Cancer: A Systematic Review

Francesco Bruno, Domenico Arcuri, Francesca Vozzo, Antonio Malvaso, Alberto Montesanto, Raffaele Maletta

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: breast cancer; Nerve Growght Factor (NGF); TrkA; p75NTR; NGFR; pro-NGF; angiogenesis; invasion; metastasis; diagnosis; prognosis; treatment

Online: 23 September 2022 (09:18:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0206.v1

Evaluation of Baseline Characteristics and Prognostic Factors in Multisystemic Inflammatory Syndrome in Children: Is It Possible to Foresee the Prognosis in the First Step?

Benhur Sirvan Cetin, Ayşenur Paç Kısaarslan, Sedanur Tekin, Merve Basol Goksuluk, Ali Baykan, Başak Nur Akyıldız, Yılmaz Seçilmiş, Hakan Poyrazoglu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; multisystem inflammatory syndrome in children (MIS-C); risk classification; prognosis

Online: 14 June 2022 (11:12:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0235.v1

Coarsened Exact Matching of Excisional to Plasma-Ablative Ab Interno Trabeculectomy

Mohamad Dakroub, Raoul Verma-Fuehring, Alicja Strzalkowska, Jost Hillenkamp, Yousef Al Yousef, Nils A. Loewen

Subject: Medicine And Pharmacology, Ophthalmology Keywords: Glaucoma; TrabEx; Trabectome; ab-interno trabeculectomy; prognosis; intraocular pressure

Online: 14 September 2021 (11:01:38 CEST)

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Working Paper ARTICLE

Identification of Nine lncRNAs Signature for Predicting Survival Benefit of Melanoma Patients Treated with Immune Checkpoint Inhibitors

Jian-Guo Zhou, Bo Liang, Jian-Guo Liu, Su-Han Jin, Si-si He, Benjamin Frey, Ning Gu, Rainer Fietkau, Markus Hecht, Hu Ma, Udo Gaipl

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lncRNA; melanoma; prognosis; immune checkpoint inhibit; WGCNA; NMF

Online: 11 July 2020 (04:35:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0324.v1

T-cytotoxic Expression of Leukocyte-Associated Immunoglobulin-like Receptor-1 (LAIR-1) in post-HCV Hepatocellular Carcinoma

Reham Hammad, Reda Badr Aglan, Shaymaa A. Mohammed, Eman Abu-elnasr Awad, Marwa A. Elsaid, Hanan .M. Bedair, Seham K. Khirala, Mohamed A. Selim, Asmaa A. Abo Elqasem, Areej Rushdi, Mohamed Ali, Omaima I Abo-Elkheir, Eman F. Sanad, Nadia M. Hamdy

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: T cytotoxic cells; Leukocyte-associated Immunoglobulin-like Receptor-1; LAIR-1; Hepatitis C virus genotype 4; HCV G4; hepatocellular carcinoma; cirrhosis; immune inhibitory checkpoints; inflammation; prognosis; insulin resistance

Online: 17 August 2022 (11:38:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0400.v1

Estimation of ALU Repetitive Element in Plasma as a Cost-Effective Liquid Biopsy Tool for Disease Prognosis in Breast Cancer

Madhumathy G Nair, Rakesh S Ramesh, Chandrakala M, Apoorva D, Snijesh VP, Vishakha Ramamurthy, Vidya M Somashekaraiah, Anupama CE, Kiruthiga Raghunathan, Anuradha Panigrahi, Manjula Das, Sujan K. Dhar, Jyothi S Prabhu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast Cancer; Liquid biopsy; ctDNA; ALU 247; Disease progression; Prognosis

Online: 21 December 2022 (11:43:52 CET)

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Background: Liquid biopsy is widely recognised as an efficient diagnostic method in oncology for disease detection and monitoring. Though examination of circulating tumor cell (CTC) is mostly implemented for assessment of genomic aberrations, need of complex methodologies for their detection has impeded its acceptance in low resource settings. We evaluated the cell free DNA (cfDNA) as a liquid biopsy tool and investigated its utility in breast cancer patients. Methods: Total cell free DNA was extracted from plasma of breast cancer patients (n=167) with median follow up of more than 5 years, at various stages of the disease. Quantitative PCR was performed to estimate the copy numbers of two fractions of ALU repetitive elements (ALU 115 and ALU 247) and DNA Integrity (DI) was calculated as the ratio of ALU 247/115. Mutations in TP53 and PIK3CA in the cfDNA was estimated by next-gen sequencing (NGS) in a subset of samples. Association of the levels of both the ALU fragments with various clinico-pathological factors and disease-free survival at various stages were examined. Nomogram models were constructed with clinical variables and ALU 247 levels to predict disease-free survival and best performing model was evaluated by decision curve analysis. Results: DI and ALU 247 levels were significantly lower (p<0.0001) in the post-operative plasma when compared to their pre-surgery levels. DI and ALU 247 were found to be significantly higher in patients with metastasis (p<0.05). Patients with higher levels of ALU 247 in their post-operative plasma had significantly poor disease-free survival (p=0.005). Higher level of ALU 247 in circulation also correlated with low tumor-infiltrating lymphocytes (TIL) within their primary tumors in the ER-negative breast cancer subtype (p=0.01). Cox proportional hazard analysis confirmed ALU 247 as an independent variable of disease-free survival both in univariate and multivariate analysis [HR 1.3 (95% CI 1.047 to 1.613, p= 0.017)]. Nomogram model showed addition of ALU 247 with other variables significantly improved (C-index-0.823) the predictive ability of the model. Conclusion: Our results confirm the utility of cfDNA as an evolving liquid biopsy tool for molecular analysis. Evaluation of larger fragment of cfDNA estimated through ALU 247 can provide vital information concurrent with the pathological process of disease evolution in breast cancer and warrants expansion to other cancer types.

Preprint ARTICLE | doi:10.20944/preprints202103.0284.v2

Benchmarking of Machine Learning Models to Assist the Prognosis of Tuberculosis

Maicon Herverton Lino Ferreira da Silva Barros, Geovanne Oliveira Alves, Lubnnia Morais Florêncio Souza, Élisson da Silva Rocha, João Fausto Lorenzato de Oliveira, Theo Lynn, Vanderson Sampaio, Patricia Takako Endo

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: machine learning; benchmarking; tuberculosis; prognosis

Online: 12 April 2021 (12:20:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0420.v1

Hodgkin Lymphoma in People Living With HIV

Jose Tomas Navarro, Jose Moltó, Gustavo Tapia, Josep Maria Ribera

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hodgkin lymphoma, HIV,; antiretroviral therapy; prognosis; etiopathogenesis

Online: 20 August 2021 (14:08:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1126.v1

High Expression of MRE11A, the Gene Involved in the Resection Step During Homologous Recombination, Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients

Daniel de Barcelos Azambuja, Helena de Castro E Glória, Gabriel e Silva Montenegro, Antonio Nocchi Kalil, Jean-Sébastien Hoffmann, Natalia Leguisamo, Jenifer Saffi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: colorectal cancer; homologous recombination; prognosis; Mre11

Online: 16 May 2023 (08:30:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0806.v1

Pediatric Hyperglycemic Hyperosmolar Syndrome: A Comprehensive Approach to Diagnosis, Management, and Complications Utilizing Novel Summarizing Acronyms

Naser Amin Zahran, Shaheen Jadidi

Subject: Public Health And Healthcare, Other Keywords: Hyperglycemic Hyperosmolar State (HHS); Diabetic Ketoacidosis (DKA); Hyperglycemia; Mixed HHS and DKA; Treatment protocols, Prognosis; Electrolyte imbalances; Patient management strategies

Online: 10 August 2023 (08:21:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0289.v1

Prognostic Value of Resistance Proteins in Plasma Cells From Multiple Myeloma Patients Treated With Bortezomib

Pawel Robak, J.; Szemraj, D.; Mikulski, I.; Drozdz, K; Juszczak, D. Jarych, W.; Robak, K; Kościelny, W.; Fendler, T.; Robak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bortezomib; cMAF; MAFb; multiple myeloma; POMP; prognosis; PFS; survival; OS

Online: 13 August 2021 (08:43:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0353.v1

Radiomics-Clinical AI Model With Probability Weighted Strategy for Prognosis Prediction in Non-small Cell Lung Cancer

Fuk-Hay Tang, Yee-Wai Fong, Shing-Hei Yung, CHi-Kan Wong, Chak-Lap Tu, Ming-To Chan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: radiomics; radiotherapy; artificial intelligence (AI; prognosis prediction; clinical factors; machine learning; non-small cell lung cancer

Online: 5 June 2023 (16:32:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0475.v1

SCAND1 Reverts EMT and Suppresses Tumor Growth and Collective Migration

Takanori Eguchi, Eva Csizmadia, Thomas L. Prince, Barbara Wegiel, Stuart K. Calderwood

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: epithelial-to-mesenchymal transition (EMT); hybrid EMT; partial EMT; mesenchymal-to-epithelial transition (MET); SCAND1; SCAN zinc finger; MZF1; cancer prognosis

Online: 31 October 2022 (08:57:38 CET)

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Epithelial-mesenchymal transition (EMT) is a reversible cellular program that transiently places epithelial (E) cells into pseudo-mesenchymal (M) cell states. The malignant progression and resistance of many types of carcinomas depends on EMT activation, partial EMT and hybrid E/M status in neoplastic cells. EMT is activated by tumor microenvironmental TGFβ signal and EMT-inducing transcription factors, such as ZEB1/2 in tumor cells. However, reverse EMT factors are less studied. We demonstrate that transcription factor SCAND1 can revert mesenchymal and hybrid E/M phenotype of cancer cells to a more epithelial, less invasive status and inhibit their proliferation and migration. SCAND1 is a SCAN domain-containing protein and hetero-oligomerizes with SCAN-zinc finger transcription factors, such as MZF1, for accessing DNA and transcriptional co-repression of target genes. We found that SCAND1-MZF1 co-expression and interaction correlated with maintaining epithelial features, whereas the simultaneous loss of SCAND1 and MZF1 correlated with mesenchymal features of tumor cells. Overexpression of SCAND1 over endogenous MZF1 in DU-145 prostate cancer cells reverted their hybrid E/M status into cobblestone morphology with increased epithelial adhesion by E-cadherin and β-catenin relocation. Consistently, co-expression analysis in TCGA PanCancer Atlas revealed that both SCAND1 and MZF1 co-express and are negatively correlated with EMT driver genes, including CTNNB1, ZEB1, ZEB2 and TGFBR, in prostate tumor specimens. In addition, SCAND1 overexpression suppressed tumor cell proliferation by reducing the MAP3K-MEK-ERK signaling pathway. Of note, SCAND1-overexpressing DU-145 cells migrated slower than control cells with decreased lymph node metastasis of prostate cancer in a mouse tumor xenograft model. Kaplan-Meyer analysis showed high expression of MZF1 and SCAND1 to correlate with better prognoses in pancreatic cancer and head and neck cancers, although with poorer prognosis in kidney cancer. Overall, these data suggest that the combination of SCAND1-MZF1 complexes may revert the EMT mechanism in cancer to establish an epithelial phenotype. These effects seem to include co-repression of EMT-driver genes and suppression of tumor cell proliferation via inhibition of the MAP3K-MEK-ERK signaling pathway.

Preprint ARTICLE | doi:10.20944/preprints202201.0042.v1

Magnetic Resonance for Differential Diagnosis of Left Ventricular Hypertrophy: Diagnostic and Prognostic Implications

Giovanni Donato Aquaro, Elisabetta Corsi, Giancarlo Todiere, Chrysanthos Grigoratos, Andrea Barison, Valerio Barra, Gianluca di Bella, Michele Emdin, Fabrizio Ricci, Alessandro Pingitore

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Left ventricular hypertrophy; Echocardiography; Magnetic Resonance; Prognosis

Online: 5 January 2022 (13:10:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0047.v1

Prognostic Impact of Visceral Fat Area Measured by Bioelectrical Impedance Analysis on Oncologic Outcomes of Colorectal Cancer

Kyeong Eui Kim, Sung Uk Bae, Woon Kyung Jeung, Seung Kyu Baek

Subject: Biology And Life Sciences, Food Science And Technology Keywords: colorectal neoplasm; nutrition assessment; body composition; electric impedance; prognosis

Online: 5 September 2022 (07:33:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0454.v1

Stress-inducible SCAN Factors Suppress the Stress Response and Are Biomarkers for Enhanced Prognosis in Cancers

Takanori Eguchi, Mona Sheta, Stuart K Calderwood

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cell stress response; heat shock protein 90 (HSP90); SCAN domain-containing proteins (SCAND); MZF1; heat shock factors (HSF); co-expression correlation; Kaplan-Meyer analysis; cancer patients prognosis

Online: 25 January 2023 (10:18:20 CET)

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Working Paper REVIEW

Revisiting the Stress Concept in the Context of Solid Tumors Prognostic: A Role for the Stress Granules?

Anais Aulas, Pascal Finetti, Shawn Lyons, François Bertucci, Daniel Birnbaum, Claire Acquaviva, Emilie Mamessier

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: stress granules; G3BP1; G3BP2; Caprin-1; USP10; TIA1; TIAR; cancer prognosis; biomarker; metastasis; resistance; cell death; pro-survival properties

Online: 7 April 2020 (01:56:12 CEST)

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Working Paper ARTICLE

A Novel Deep Clustering Method and Indicator for Time Series Soft Partitioning

Alexandre Eid, Guy Clerc, Badr Mansouri, Stella Roux

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: semantic segmentation; time series; clustering; deep learning; kernel density estimation; electromechanical actuator; data labelling; prognosis and health management; aeronautics

Online: 26 July 2021 (17:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0828.v1

ZEB1 Hypermethylation Is Associated with Better Prognosis in Patients with Colon Cancer

Irene Fernández De Los Reyes, Marisa Gómez-Dorronsoro, Iñaki Monreal-Santesteban, Agustin F Fernandez, Mario Fraga, Pablo Azcue, Laura Alonso, Beatriz Fernandez-Marlasca, Javier Suárez-Alecha, Alicia Córdoba-Iturriagagoitia, David Guerrero-Setas

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: methylation; prognosis; colon cancer; biomarkers

Online: 12 July 2023 (11:09:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0104.v1

HLA-G 14bp ins/del Polymorphism, Plasma Level of Soluble HLA-G and Association with IL-6/IL-10 Ratio and Survival of Glioma Patients

Maria Bucova, Kristina Kluckova, Jan Kozak, Boris Rychly, Marian Svajdler, Viktor Matejcik, Juraj Steno, Eszter Zsemlye, Vladimíra Ďurmanová

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: glioma; HLA-G; IL-6; polymorphism; prognosis; survival

Online: 7 December 2021 (12:55:23 CET)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202301.0473.v1

Prognosease: A Data Generator for Health Deterioration Prognosis

Tarek BERGHOUT, Mohamed Benbouzid

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Data generator; dataset; deep learning; health index; machine learning; prognosis and health management; remaining useful life

Online: 26 January 2023 (08:37:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.1725.v1

Molecular Insights into the Role of Gut Microbiota in Antibiotic Therapy Selection and Resistance Mitigation

Mihaela Andreescu

Subject: Medicine And Pharmacology, Hematology Keywords: Molecular biology; infectious diseases; clinical diagnostic; early detection; prognosis

Online: 25 May 2023 (03:34:18 CEST)

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Working Paper ARTICLE

Prognostic Impact of Immunoglobulin Kappa C (IGKC) In Early Breast Cancer

Marcus Schmidt, Karolina Edlund, Jan G Hengstler, Anne-Sophie Heimes, Katrin Almstedt, Antje Lebrecht, Slavomir Krajnak, Marco J. Battista, Walburgis Brenner, Annette Hasenburg, Jörg Rahnenführer, Mathias Gehrmann, Pirkko-Liisa Kellokumpu-Lehtinen, Ralph M Wirtz, Heikki Joensuu

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: triple-negative breast cancer; prognosis; immune system; immunoglobulin kappa C

Online: 31 May 2021 (12:27:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0242.v1

Effectiveness of Abdominal Ultrasonography for Improving the Prognosis of Pancreatic Cancer during Medical Checkup: A Single Center Retrospective Analysis

Atsushi Yamaguchi, Naohiro Kato, Syuhei Sugata, Takuro Hamada, Nao Furuya, Takeshi Mizumoto, Yuzuru Tamaru, Ryusaku Kusunoki, Toshio Kuwai, Hirotaka Kouno, Naoyuki Toyota, Takeshi Sudo, Kazuya Kuraoka, Hiroshi Kohno

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: pancreatic cancer (PC); abdominal ultrasonography (US); surveillance; prognosis; medical checkup; 5-year survival; cancer screening

Online: 16 September 2022 (08:08:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0951.v1

Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases

Anna Smukowska-Gorynia, Weronika Gościniak, Patrycja Woźniak, Sylwia Iwańczyk, Karolina Jaxa-Kwiatkowska, Sylwia Sławek-Szmyt, Magdalena Janus, Jerzy Paluszkiewicz, Tatiana Mularek-Kubzdela

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: pulmonary arterial hypertension associated with connective tissue diseases; drugs; novel drugs; therapy; treatment; prognosis

Online: 11 August 2023 (13:25:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0068.v1

Is there a Role of Warburg Effect in Prostate Cancer Aggressiveness? Analysis of Expression of Enzymes of Lipidic Metabolism by Immunohistochemistry in Prostate Cancer Patients (DIAMOND Study)

Giorgio Ivan Russo, Maria Giovanna Asmundo, Arturo Lo Giudice, Giuseppe Trefiletti, Sebastiano Cimino, Matteo Ferro, Riccardo Lombardo, Cosimo De Nunzio, Giuseppe Morgia, Eliana Piombino, Maria Failla, Rosario Caltabiano, Giuseppe Broggi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: prostate cancer; Warburg effect; prognosis; radical prostatectomy; lipidic; metabolism; mortality

Online: 5 December 2022 (08:50:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0222.v1

Exosomes as Novel Diagnostic and Therapeutic Agents for Non-melanoma Skin Cancer: A Systematic Review

Konstantinos Seretis, Elena Boptsi, Anastasia Boptsi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: non-melanoma skin cancer; basal cell carcinoma; cutaneous squamous cell carcinoma; exosomes; extracellular vesicles; biomarker; treatment; diagnosis; prognosis

Online: 3 January 2024 (09:43:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0635.v1

Innate Immune Gene Polymorphisms and COVID‐19 Prognosis

Evangelos Bakaros, Ioanna Voulgaridi, Vassiliki Paliatsa, Nikolaos Gatselis, Georgios Germanidis, Evangelia Asvestopoulou, Stamatia Alexiou, Elli Botsfari, Vasiliki Lygoura, Olga Tsachouridou, Iordanis Mimtsoudis, Maria Tseroni, Styliani Sarrou, Varvara A. Mouchtouri, Katerina Dadouli, Fani Kalala, Simeon Metallidis, George Dalekos, Christos Hadjichristodoulou, Matthaios Speletas

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID‐19; IL18; TLR2; TLR4; CD14; CD40; CARD8; innate immunity; polymorphism; prognosis

Online: 8 August 2023 (11:53:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0202.v1

Clinical Profiles and One-Year Outcome in Middle Eastern Pa-Tients With Atrial Fibrillation and Major Bleeding Events

Rashid Ibdah, Sukaina Ismael Rawashdeh, Ayman Hammoudeh, Yahya Badaineh, Yousef Khader, Ramzi Tabbalat, Mustafa Jammal, Sadan Aburumman, Ahmad Sadam Shannaq, Imad A. Alhaddad

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Atrial fibrillation; Major bleeding events; Clinically-relevant non-major bleeding; Oral anticoagulants; Middle Eastern population; Prognosis

Online: 13 March 2023 (02:06:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0298.v1

D-dimer Trends Predicts COVID-19 Patient’s Prognosis: A Retrospective Chart Review Study

Raeed Kabir, Iyana Malik, Reena Chen, Jebun Nahar, Xiongying Chen, Mahfouz Hoq, Azad Kabir

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; SARS-CoV-2; anticoagulation; enoxaparin; bleeding risk; prognosis; oxygen; vaccination; D-dimer; non-critically ill

Online: 13 April 2023 (05:32:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1572.v1

The Prognostic Nutritional Index (PNI): A New Biomarker for Determining Prognosis in Metastatic Castration-Sensitive Prostate Carcinoma

Halil İbrahim Ellez, Merve Keskinkilic, Huseyin Salih Semiz, Mehmet Emin Arayici, Erdem Kısa, Ilhan Oztop

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: prostate cancer; prognostic nutritional index; inflammation; prognosis

Online: 23 May 2023 (04:50:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0152.v1

Targeting Cytochrome P450 Enzymes in Ovarian Cancers: new approaches for Tumour-Selective Interventions

Yousef M. Al-saraireh, Fatemah O. F. O. Alshammari, Omar H. Abu-azzam, Sa’ed M. Al-dalain, Yahya M. Al-sarayra, Mansour Haddad, Hafiz Makeen, Aiman Al-Qtaitat, Mohammad Almermesh, Sameeh A. Al-sarayreh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cytochromes P450; ovarian cancer; gynecologic cancers; pro-drug; xenobiotics; prognosis

Online: 4 September 2023 (11:58:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0335.v1

Prognostic Factors in Epithelioid Hemangioendothelioma: Analysis of a Nationwide Molecularly/Immunohistochemically Confirmed Cohort of 57 Cases

Tess Tomassen, Yvonne M H Versleijen-jonkers, Melissa H S Hillebrandt-roeffen, Patricia H J Van Cleef, Thijs Van Dalen, Marije E Weidema, Ingrid M E Desar, Uta Flucke, Joost M Van Gorp

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Epithelioid hemangioendothelioma; Aggressive; Malignant; Prognosis; Risk stratification; Lymph node

Online: 5 June 2023 (14:26:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2025.v1

Pan-Cancer Profiling of Intron Retention and Its Clinical Significance in Diagnosis and Prognosis

Leihuan Huang, Xin Zeng, Haijing Ma, Yu Yang, Yoshie Akimoto, Gang Wei, Ting Ni

Subject: Biology And Life Sciences, Life Sciences Keywords: intron retention; RNA-seq; cancer; diagnosis; prognosis

Online: 30 August 2023 (14:10:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0391.v1

Feature Selection in the Context of Prognostic Health Management

Indrawata Wardhana

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: prognosis and health management, preprocessing data, feature extraction, feature selection.

Online: 22 March 2023 (04:31:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0015.v1

Serum Biomarkers of Inflammation in the Identification and Prognostication of Frail Patients Undergoing Emergency Laparotomy

Michael George, Rajarshi Mukherjee

Subject: Medicine And Pharmacology, Surgery Keywords: Frailty; elderly; inflammageing; inflammation; biomarkers; prognosis; outcomes; emergency; laparotomy; surgery

Online: 3 April 2023 (08:20:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1185.v1

Chasing Circulating Biomarkers in Renal Cell Carcinoma: the Case of Extracellular Vesicles and their miRNA Cargos

Ilenia Mastrolia, Virginia Catani, Marco Oltrecolli, Stefania Pipitone, Maria Giuseppa Vitale, Valentina Masciale, Chiara Chiavelli, Carlo Augusto Bortolotti, Cecilia Nasso, Giulia Grisendi, Roberto Sabbatini, Massimo Dominici

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: renal cell carcinoma; liquid biopsy; blood; extracellular vesicles; microRNA; biomarker; diagnostics; prognosis; prediction

Online: 28 April 2023 (13:00:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0395.v1

ANN Based Estimation of the Defects Severity at the Drilling of GFRP/Ti Multilayered Composite Structure

Igor Zhilyaev, Evgeny Chigrinets, Sergey Shevtsov, Samira Chotchaeva, Natalia Snezhina

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: polymeric composite drilling; GFRP reinforced with Ti interlayers; hole drilling quality; delaminations; defect severity prediction; ANN based prognosis of the quality; tool geometry and machining conditions.

Online: 22 November 2022 (02:32:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1136.v1

High HER2 intratumoral heterogeneity is a predictive factor for poor prognosis in Early-stage and Locally Advanced HER2-positive Breast Cancer

Tomonori Tanei, Shigeto Seno, Yoshiaki Sota, Kaori Abe, Nanae Masunaga, Masami Tsukabe, Tetsuhiro Yoshinami, Tomohiro Miyake, Masafumi Shimoda, Hideo Matsuda, Kenzo Shimazu

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Breast carcinoma, Intratumoral heterogeneity, HER2 gene expression, Prognosis, Breast Neoplasms

Online: 20 February 2024 (14:26:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1767.v1

Usefulness of Tumor Marker Score for Prediction of Prognosis in Hepatocellular Carcinoma Patients Treated with Atezolizumab plus Bevacizumab: A Multicenter Retrospective Study

Kazunari Tanaka, Kunihiko Tsuji, Atsushi Hiraoka, Toshifumi Tada, Masashi Hirooka, Kazuya Kariyama, Joji Tani, Masanori Atsukawa, Koichi Takaguchi, Ei Itobayashi, Shinya Fukunishi, Toru Ishikawa, Kazuto Tajiri, Hironori Ochi, Hidenori Toyoda, Chikara Ogawa, Takashi Nishimura, Takeshi Hatanaka, Satoru Kakizaki, Noritomo Shimada, Kazuhito Kawata, Atsushi Naganuma, Hisashi Kosaka, Tomomitsu Matono, Hidekatsu Kuroda, Yutaka Yata, Hideko Ohama, Fujimasa Tada, Kazuhiro Nouso, Asahiro Morishita, Akemi Tsutsui, Takuya Nagano, Norio Itokawa, Tomomi Okubo, Taeang Arai, Keisuke Yokohama, Hiroki Nishikawa, Michitaka Imai, Yohei Koizumi, Shinichiro Nakamura, Hiroko Iijima, Masaki Kaibori, Yoichi Hiasa, Takashi Kumada

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; tumor marker; atezolizumab plus bevacizumab; prognosis; predictive model

Online: 26 June 2023 (09:42:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0096.v1

Mismatch Repair, p53, and L1 Cell Adhesion Molecule States Influence the Response to Chemotherapy in Advanced and Recurrent Endometrial Cancer

Jung Chul Kim, Byungsoo Ahn, Yong Jae Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim, Eunhyang Park, Jung-Yun Lee

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Endometrial neoplasms; molecular classification; Neural cell adhesion molecule L1 (L1CAM); Prognosis; Recurrence; Survival

Online: 4 July 2023 (03:52:30 CEST)

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