ARTICLE | doi:10.20944/preprints201906.0095.v1
Subject: Keywords: paracetamol; laser-induced breakdown spectroscopy; cyanide; carbon Swan bands; principal component analysis; Raman spectroscopy; Fourier-Transform-infra-red spectroscopy
Online: 11 June 2019 (10:42:58 CEST)
Laser-induced breakdown spectroscopy (LIBS) of pharmaceutical drugs that contain paracetamol is investigated in air and argon atmospheres. Characteristic neutral and ionic spectral lines of various elements and molecular signatures of CN violet and C2 Swan band systems are observed. The relative hardness of all drug samples is measured as well. Principal component analysis, a multivariate method, is applied in data analysis for demarcation purposes of the drug samples. The CN violet and C2 Swan spectral radiances are investigated for evaluation of possible correlation of the chemical and molecular structures of the pharmaceuticals. Complementary Raman and Fourier-transform-infra-red spectroscopies are used record molecular spectra of the drug samples. The applicationof the above techniques for the drug screening are important for identification and mitigation of drugs that reveal additives that may cause adverse side-effects.
ARTICLE | doi:10.20944/preprints201807.0319.v1
Subject: Physical Sciences, Applied Physics Keywords: laser-induced breakdown spectroscopy; atomic spectroscopy; plasma spectroscopy; laser spectroscopy; physical properties of biomaterials
Online: 18 July 2018 (08:34:46 CEST)
This work reports measurements of calcified gallstone elemental compositions using laser-induced optical emission spectroscopy. The experimental results support the importance of the magnesium concentration in gallstone growth. Granular stones reveal an increased magnesium concentration at the periphery of the granules, suggesting the inhibition of further growth. Non-granular gallstones reveal lower overall magnesium concentrations but with higher values near the center.
ARTICLE | doi:10.20944/preprints202209.0337.v1
Subject: Physical Sciences, Applied Physics Keywords: optical emission spectroscopy; laser induced optical breakdown; trichosanthes dioica; pointed gourd; diabetes; biomedicine; biophysics
Online: 22 September 2022 (09:41:00 CEST)
This interdisciplinary work communicates identification and quantification of elements responsible for the bioactive potency of leaves from pointed gourd, trichosanthes dioica,using laser induced breakdown spectroscopy (LIBS). Calibration-free LIBS determines the presence of various trace and major elements, their concentrations, and ratios in which they are present in the leaves. The presence of specific elemental ratios of magnesium/sodium and magnesium/potassium could be promising for managing diabetes mellitus. Variable doses of 500, 750, 1000, and 1250 mg per kg body weight of aqueous extract from trichosanthes dioica leaves are administered. A dose of 1000 mg per kg body weight is found to be the most effective. Based on encouraging results, the extract could be harvested to serve as anti-diabetic medication for diabetes and associated symptoms.