The dentate gyrus (DG) is part of the hippocampal formation and is essential for important cognitive processes such as navigation and memory. The oscillatory activity of the DG network is believed to play a critical role in cognition. DG circuits generate three main rhythms: theta, beta, and gamma, which participate in the specific information processing performed by DG neurons. In the temporal lobe epilepsy (TLE), cognitive abilities are impaired, which may be due to drastic alterations in the DG structure and network activity during epileptogenesis. The theta rhythm and theta coherence are especially vulnerable in dentate circuits; disturbances in DG theta oscillations and their coherence may be responsible for general cognitive impairments observed during epileptogenesis. Some researchers suggested that the vulnerability of DG mossy cells is a key factor in the genesis of TLE, but others did not support this hypothesis. The aim of the review is not only to present the current state of the art in this field of research but to help pave the way for future investigations by highlighting the gaps in our knowledge to completely appreciate the role of DG rhythms in brain functions. Disturbances in oscillatory activity of the DG during TLE development are described in detail that may be a diagnostic marker in the treatment of this disease.

Hippocampus plays a crucial role in spatial and episodic memory. The acquisition of new memories is impossible without participation of the hippocampus. There are two main functional states or “modes” of the hippocampal activity, theta and non-theta state. They have different behavioral correlates and clearly different spectral content of the LFPs and neuronal spiking. Hippocampal theta state is present under active exploratory behavior, locomotion, cognitive situations requiring attention and REM sleep. Slow-wave sleep and quiet wakefulness (immobility, eating, grooming) represent the non-theta hippocampal state. The nodal point for the regulation of hippocampal activity is the MS. The activation or suppression of different types of MS cells appears to be responsible for controlling hippocampal theta and non-theta states. Functional coupling between MS neurons and hippocampal interneurons varies in a state-dependent manner.

The brain rhythms are essential for information processing in neuronal networks. Oscillations recorded in different brain regions can be synchronized and have a constant phase difference, i.e. be coherent. Coherence between local field potential (LFP) signals from different regions in the brain may be correlated with the performance of cognitive tasks, from which it is concluded that these regions of the brain are involved in the task performance together. In this review, we discuss why coherence occurs and how it is coupled to the information transfer between different regions of the hippocampal formation. Coherence in theta and gamma frequency ranges is described since these rhythms are most pronounced during the hippocampus-dependent attention and memory. We review in vivo studies of interactions between different regions of the hippocampal formation in theta and gamma frequency bands. The kay provisions of the review: 1) coherence emerges from synchronous postsynaptic currents in principal neurons, occurring as a result of synchronization of neuronal spike activity; 2) synchronization of neuronal spike patterns in two regions of the hippocampal formation can be realised through induction or resonance; 3) coherence at a specific time point reflects the transfer of information between regions of the hippocampal formation, in particular, gamma coherence reflects the coupling of active neuronal ensembles. Overall, coherence is not an epiphenomenon, but an important physiological process that has certain generation mechanisms and performs important functions in information processing and transmission across the brain regions.