CONCEPT PAPER | doi:10.20944/preprints202203.0404.v1
Subject: Medicine & Pharmacology, Other Keywords: Polypill; Cardiovascular Risk; Primary Prevention; Secondary Prevention; Adherence; Cost-effectivity
Online: 31 March 2022 (10:01:28 CEST)
INTRODUCTION: Primary and secondary cardiovascular prevention programs present less efficacy than desired due to the professionals’ lack of adherence when prescribing different drugs to the same patient, and due to patients’ lack of adherence in the medium and long term to medications prescribed. Polypills are considered as a possible solution to these problems. An evidence-based review about a cardiovascular prevention polypill efficacy and a guide for its use is presented.METHODS: Comprehensive bibliographical review of the evidence published on the polypill as a mechanism for facilitating medication adherence in primary and secondary cardiovascular prevention.RESULTS: A total of 31 published articles were included, showing the options of the polypill as a method of primary and secondary cardiovascular prevention. Polypill can increase the therapeutic adherence of patients in the medium and long term, also increasing therapeutic results compared to the administration of the same different drugs separately. Based on the evidence, a flow chart for the prescription of a polypill has been developed.DISCUSSION AND CONCLUSIONS: The use of a polypill increases the effectiveness and adherence of patients to primary and secondary cardiovascular prevention programs, without increasing the cost of the intervention. The use of a polypill in cardiovascular prevention can be effective as a prescription tool.
BRIEF REPORT | doi:10.20944/preprints202209.0340.v1
Subject: Medicine & Pharmacology, Sport Sciences & Therapy Keywords: Locomotion; Motor Control; Muscle Synergies; Physiology; Running
Online: 22 September 2022 (10:30:24 CEST)
Instep weights cause mechanical changes, modifying muscle activity and changing ground plantar support. 30 semi-professional sprinters, randomized in 3 groups [no-weight, Ascending (50, 100, 150 and 200g), Descending (200, 150, 100 and 50g)] run 6 consecutive 50-meter series at maximum speed (first and sixth without weights); partial, total times and speed were analyzed. Instep weights were safe and well tolerated. 6th series speed decreased except in men’s ascending group, who achieved a lower time in sixth compared to first series. Weights presented in ascending order in men during warm-up could improve running time. Instep weights neuromuscular effects could compensate men’s tiredness in last series; weights could be included in training methodologies. Men training weights presented in ascending order may provide better results.