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Preprint ARTICLE | doi:10.20944/preprints202202.0132.v1

Differential Acellular Reactive Oxygen Species (ROS) Generation by E-cigarettes Containing Tobacco-Free Nicotine (TFN) and Tobacco-Derived Nicotine

Shaiesh Yogeswaran, Irfan Rahman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Tobacco Free Nicotine (TFN); Synthetic Nicotine; Tobacco-derived Nicotine; vape-bar; Electronic Nicotine Delivery Systems; Reactive Oxygen Species (ROS)

Online: 9 February 2022 (10:37:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0122.v1

Comparative Reactive Oxidative Species (ROS) Content among Disposable Flavored Vape Bars

Shaiesh Yogeswaran, Thivanka Muthumalage, Irfan Rahman

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Vaping, disposable e-cigarettes, vape bars, flavoring, flavoring chemicals, Reactive Oxidative Species (ROS), disposables, oxidative stress

Online: 4 August 2021 (21:48:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0264.v1

Dysregulated Metabolites Serve as Novel Biomarkers for Metabolic Diseases Caused by Vaping and Cigarette Smoking

Qixin Wang, Xianming Ji, Irfan Rahman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Metabolome; TCA; Lipids; e-cigarette; cigarette; biomarkers

Online: 9 April 2021 (14:30:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0220.v2

Epithelial Ablation of Miro1/Rhot1 GTPase Leads to Mitochondrial Dysfunction and Lung Inflammation by Cigarette Smoke

Shikha Sharma, Qixin Wang, Thivanka Muthumalage, Irfan Rahman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: MIRO1; mitochondrial dysfunction; cigarette smoke; mitophagy; COPD.

Online: 21 September 2021 (10:56:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0354.v1

Multi-Walled Carbon Nanotubes (MWCNTs) Cause Cellular Senescence in TGF-β Stimulated Lung Epithelial Cells

Joseph Lucas, Qixin Wang, Thivanka Muthumalage, Irfan Rahman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: MWCNT; senescence; pulmonary fibrosis; epithelial

Online: 14 May 2021 (17:05:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0639.v1

ENDS Tobacco Flavors, Public Health, and Toxicity

Sun Yehao, Thomas Lamb, Prital Prabhu, Dongmei Li, Scott McIntosh, Irfan Rahman

Subject: Biology And Life Sciences, Toxicology Keywords: Vaping; e-cigarettes; tobacco flavors; toxicity; regulation

Online: 8 June 2023 (10:59:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0334.v1

Environmental Exposures and Phenotype of Non-smoking COPD

Sameer Arbat, Ashok Arbat, Bharat Agrawal, Parimal Deshpande, Irfan Rahman, Swapnil Bakamwar, Prajakta Borkar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: non-smoking COPD; phenotypes; air pollution; biomass; occupational exposure

Online: 24 June 2022 (08:18:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0449.v1

Classification, Perception, Sociological Aspects, and Toxicity of Emerging Flavored Oral Nicotine Pouches

Sadiya Bi Shaikh, Chad Newton, Wai Cheung Tung, Yehao Sun, Dongmei Li, Deborah Ossip, Irfan Rahman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: ONPs; tobacco; nicotine; flavors; perception; toxicity; menthol

Online: 25 January 2023 (09:33:04 CET)

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Introduction: Oral Nicotine Pouches (ONPs) are the new form of nicotine pouches that have become a type of emerging smokeless tobacco product sold by various tobacco companies. These smokeless tobacco products are being marketed for usage all over as Snus containing tobacco-derived nicotine (Natural) or as tobacco-free nicotine (Synthetic) as substitutes for other tobacco products that are limited in public places. ONPs have become popular tobacco products among adolescents/young adults and over 50% of young adult users of ONP use flavored ONP, such as menthol/mint, tobacco, dessert/candy, and fruity, being the most popular flavors. Various new ONP flavors are currently popular locally as well in the online market. Tobacco, Menthol, and fruit-flavored ONPs could motivate cigarette smokers to alteration to ONPs. Methods: We expanded our knowledge on natural/synthetic ONP flavors wheels to available data on ONPs, describing in detail their flavors and brands (US and Europe) in both natural/Synthetic ONP categories. We classified over 152 snus and 228 synthetic ONPs into the following flavor categories: “Tobacco”, “Menthol/Mint”, “Fruity”, “Candy/Deserts”, “Drink”, “Aroma”, “Spices” and “Mixed Flavors”. Results: Based on total numbers, wefound that the most popular ONPs flavor sold as tobacco and menthol to be among natural ONPs, among synthetic ONPs fruity and menthol as the most prominent flavors with varying concentrations of nicotine and other flavoring chemicals including coolant WS-23. We also illustrated possible molecular targets and toxicities due to exposure to ONPs activating several signaling cascades like AKT and NF-B might possibly lead to apoptosis and epithelial mesenchymal transition (EMT). Conclusions: Considering the marketing of ONP products with various flavor profiles and most of these products containing tobacco/menthol/fruit flavor, it is likely to have regulation and marketing disclaimer on some of these products. Further, it would be logical to determine how the market reacts in terms of compliance and non-compliance with flavor restrictions by the regulatory agencies.

Preprint REVIEW | doi:10.20944/preprints202304.0073.v1

Vaping Greed: Perception, Social Media, Marketing, Public Health, and Toxicity

Yehao Sun, Chad Newton, Prital Prabhu, Alannah Dalton, Desjamebra Robinson, Dongmei Li, Scott McIntosh, Irfan Rahman

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Vaping; e-cigarettes; addiction; social; flavors; nicotine; toxicity

Online: 6 April 2023 (05:40:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0520.v1

Distinct Exosomal miRNA Profiles from BALF and Lung Tissue from COPD and IPF Patients

Gagandeep Kaur, Krishna Maremanda, Michael Campos, Hitendra Singh Chand, Feng Li, Nikhil Hirani, M A Haseeb, Irfan Rahman

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Exosomes; COPD; smokers; IPF; BALF; lung

Online: 27 August 2021 (11:33:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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