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Preprint ARTICLE | doi:10.20944/preprints201908.0010.v1

Kalina-Flash Cycle Performance Analysis and Parametric Optimization

Raveendra Nath R, C. Vijaya Bhaskar Reddy, K.Hemachandra Reddy

Subject: Engineering, Mechanical Engineering Keywords: genetic algorithm; Kalina cycle; energy efficiency; Exergy efficiency;

Online: 1 August 2019 (06:13:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0227.v1

Converting Ensemble Clustering Problem to a Mathematical Optimization Problem and Providing an Approach to Solve Based on Optimization Toolbox

Simintaj Salehpour, Hamid Parvin

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Ensemble clustering; cluster stability; F-measure; co-association matrix; genetic algorithm

Online: 17 April 2018 (15:58:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0075.v1

Deep Network Optimization Using a Genetic Algorithm for Recognizing Hand Gestures via EMG Signals

Kasra Sehat, Seyed Mohammadreza Shokouhyan, Nada K. Abdallah, Kinda Khalaf

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: EMG; optimization; genetic algorithm; deep learning

Online: 4 January 2023 (09:21:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2104.v1

Optimization of Dual-Design Operation Ventilation System Network Based on Improved Genetic Algorithm

Yanbo Feng, Han Zhu, Xiwen Feng, Qianru Chen, Xiangyu Sun, Zhengrong Li

Subject: Engineering, Architecture, Building And Construction Keywords: ventilation system networks; design optimization; genetic algorithm

Online: 1 November 2023 (03:55:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0114.v1

Design and Multi-Objective Optimization of a Photovoltaic System by a Genetic Algorithm

Khadidjatou Thiaw, Amadou Diao, Amy Sadio, Senghane Mboji

Subject: Physical Sciences, Applied Physics Keywords: photovoltaic system; LPSP; TLCC; optimization; genetic algorithm

Online: 4 September 2023 (03:50:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0430.v1

Optimization of Water Distribution Networks Using Genetic Algorithm based SOP–WDN Program

Uchit Sangroula, Kuk-Heon Han, Kang-Min Koo, Kapil Gnawali, Kyung-Taek Yum

Subject: Engineering, Civil Engineering Keywords: Water distribution networks; Optimization; Genetic Algorithm; EPANET

Online: 28 January 2022 (08:53:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1093.v1

Optimization of Dieldrin Selection for the Genetic Sexing of Aedes albopictus

Sarah Scussel, Benjamin Gaudillat, Jérémy Esnault, Quentin Lejarre, Marianne Duployer, Daouia Messaoudi, Patrick Mavingui, Pablo Tortosa, Julien Cattel

Subject: Biology And Life Sciences, Insect Science Keywords: Aedes albopictus; genetic sexing strain; insecticide selection; dieldrin quantification

Online: 15 June 2023 (07:45:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1810.v1

Global Optimization Theories and Techniques for COVID-19

zhiyi Wang, Xin Wen, Zhihai Lu

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Global Optimization; COVID-19; Genetic Algorithms; Particle Swarm Optimization; Cat Swarm Optimization

Online: 27 October 2023 (12:55:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0172.v1

Oriented Crossover in Genetic Algorithms for Computer Networks Optimization

Furkan Rabee, Zahir M. Hussain

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Genetic Algorithm; Uniform Crossover; Network Protocol Optimization; Routing Algorithm; Optimization; Oriented Crossover

Online: 11 April 2023 (02:43:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1324.v1

An intelligent technique for initial distribution in stochastic optimization methods

Vasileios Charilogis, Ioannis G. Tsoulos, VASILIOS STAVROU

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: optimization; genetic algorithm methods; initialization distribution; evolutionary techniques; stochastic methods; termination rules

Online: 20 September 2023 (07:35:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0129.v1

Nonlinear Modeling and Coordinate Optimization of Semi-Active Energy Regenerative Suspension with Electro-Hydraulic Actuator

Farong Kou, Jiafeng Du, Zhe Wang, Dong Li, Jianan Xu

Subject: Engineering, Automotive Engineering Keywords: semi-active suspension; feed energy; parameter optimization; genetic algorithm

Online: 19 December 2017 (06:53:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1263.v1

Genetic Algorithms Optimization of Beams in Terms of Maxim-Izing Gaps Between Adjacent Frequencies

Łukasz Domagalski, Izabela Kowalczyk

Subject: Engineering, Civil Engineering Keywords: genetic algorithms; optimization; band-gaps; beams; eigenproblem; dynamic analysis; finite element method

Online: 19 June 2023 (02:56:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1318.v1

Advances in Machine Learning for Monitoring, Control, and Optimization of Temperature of Reactors

Iftikhar Ahmad

Subject: Engineering, Chemical Engineering Keywords: reactor operations; Machine Learning (ML); optimization; Artificial Neural Networks (ANNs); Genetic Algorithms (GAs)

Online: 20 September 2023 (08:59:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0081.v1

Electric Power Grids Distribution Generation System For Optimal Location and Sizing – An Case Study Investigation by Various Optimization Algorithms

Ahmet Ali, Sanjeevikumar Padmanaban, Bhekisipho Twala, Tshilidzi Marwala

Subject: Engineering, Electrical And Electronic Engineering Keywords: optimization; simulated annealing; genetic algorithm; power losses; power consumption

Online: 9 May 2017 (10:45:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1745.v1

Optimized FIR Filter using Genetic Algorithms: A Case Study of ECG Signals Filter Optimization

Houssam Hamici, Awos Kanan, Khalid Al-hammuri

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Genetic Algorithms; Digital Filters; Metaheuristic Optimization; Finite Impulse Response (FIR); Side Lobe Level (SLL).

Online: 24 August 2023 (10:46:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0015.v1

Evolutionary Optimization of Colebrook’s Turbulent Flow Friction Approximations

Dejan Brkić, Žarko Ćojbašić

Subject: Physical Sciences, Fluids And Plasmas Physics Keywords: colebrook equation; colebrook-white; moody diagram; turbulent flow; hydraulic resistance; darcy friction; pipes; genetic algorithms; optimization techniques; error analysis

Online: 2 March 2017 (07:57:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0613.v1

Process Optimization, Genetic Programming Modeling and Reliability Assessment of Bioactive Extracts Recovery From Phyllantus Emblica

Hamdan Alanzi, Hamoud Alenezi, Oladayo Adeyi, Abiola J. Adeyi, Olusola Emmanuel, Chee-Yuen Gan, Olusegun Abayomi Olalere

Subject: Engineering, Chemical Engineering Keywords: Phyllantus emblica leaf; bioactive extract; heat-assisted technology; multi gene genetic programming; reliability assessment

Online: 9 November 2023 (07:54:45 CET)

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The feasibility of recovering bioactive antioxidants from Phyllantus emblica leaves using ethanol -water mixture (0 – 100%) and heat-assisted extraction technology (HAE-T) was investigated in this present study. To this effect, the process parameter of operating temperature (OT: 30 -50 oC), solid -to-liquid ratio (S:L: 1:20 - 1:60 g/mL) and extraction time (ET: 45 - 180 min) were investigated on the extract total phenolic content (TPC, mg GAE/g d.w), yield (EY, %) and antioxidant activity (μM AAE/g d.w) by employing the Box-Behnken experimental design (BBD) available in response surface methodology (RSM). Multi-objective process optimization using the desirability function algorithm to determine set of process variables that simultaneously optimize process responses of TPC, EY and AA was also investigated. The recovery process was thereafter modeled with BBD-RSM and multi gene genetic programming (MGGP) algorithm and model reliability assessment via Monte Carlo simulation were conducted for the best performing set of models for predicting TPC, EY and AA values. The HPLC characterization of the recovered extract was carried out to ascertain the phenolic compound constituents of the Phyllantus emblica leaf extract. The 50% ethanol solution was found to be the best for the optimal extraction of antioxidants from Phyllantus emblica leaves. The HAE-T was suitable for recovering bioactive extract from Phyllantus emblica leaves and investigated process parameters have impacts on the recovery process. The process parameters that simultaneously gave the optimum EY of 21.6565%, TPC of 67.116 mg GAE/g and AA of 3.68583 µM AAE/g were OT of 41.61 oC, S:L of 1:60 g/mL and ET of 180 min. The HPLC extract profiling revealed that the bioactive constituents present in the recovered extract were betulinic acid, gallic acid, chlorogenic acid, caffeic acid, ellagic acid, and ferulic acid. Both the developed BBD-RSM and evolved MGGP-based models predicted the observed process response of TPC, EY and AA satisfactorily with BBD-RSM models marginally better in their predictions. The reliability results showed that the BBD-RSM models predicted TPC, EY and AA values with high certainty of 99.985%, 97.569% and 98.661%, respectively.

Preprint ARTICLE | doi:10.20944/preprints201704.0148.v1

Multi-objective Optimization of Draft Tube in Francis Turbine Using DOE, RBF and NSGA-II

Chol Nam Mun, De Chun Ba, Xiang Ji Yue, Myong Il Kim

Subject: Engineering, Energy And Fuel Technology Keywords: francis turbine; draft tube; optimization design; experiment of design; non–dominated sorting genetic algorithm

Online: 24 April 2017 (10:52:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1376.v1

A New Optimization Design Method of Multi-Objective Indoor Air Supply Using Kriging Model and NSGA-II

Yu Guo, Yukun Wang, Yi Cao, Zhengwei Long

Subject: Engineering, Architecture, Building And Construction Keywords: air supply optimization; double-objective optimization; surrogate-based optimization; Kriging model; genetic algorithm

Online: 21 August 2023 (03:23:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0317.v1

Performance of Resource Allocation in Device-to-Device Communication Systems Based on Evolutionally Optimization Algorithms

Hsu-Tan Tan, Bor-An Chen, Yung-Fa Huang

Subject: Engineering, Electrical And Electronic Engineering Keywords: device-to-device; LTE systems; resource allocation; particle swarm optimization algorithm; genetic algorithm; system capacity

Online: 20 June 2018 (09:31:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0018.v1

Hybrid Optimization Model for Conjunctive Use of Surface and Groundwater Resources in Water Deficit Irrigation System

Karthikeyan MoothampalayamSampathkumar, Saravanan Ramasamy, Balamurugan Ramasubbu, Hamid Reza Pourghasemi, Saravanan Karuppanan, Balaji Lakshminarayanan

Subject: Engineering, Automotive Engineering Keywords: conjunctive use; cropping pattern; genetic algorithm; bacterial foraging optimization; ant colony optimization; hybrid optimization; productivity

Online: 4 January 2021 (11:31:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0298.v1

A Composite Hybrid Feature Selection Learning-Based Optimization of Genetic Algorithm For Breast Cancer Detection

Ahmed Abdullah Farid, Gamal Selim, Hatem Khater

Subject: Computer Science And Mathematics, Information Systems Keywords: Data Mining; Breast Cancer; Hybrid Feature Selection; Machine learning; Support Vector Machine; Optimize Genetic Algorithm; boosting algorithms

Online: 19 March 2020 (11:13:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1870.v1

Optimization of water-jet pump based on the coupling of multi-parameter and multi-objective genetic algorithms

Yun Long, Tian Chenbiao, Qiang Zhuang, Zhu Rongsheng, Junlian Yin, Dezhong Wang

Subject: Engineering, Marine Engineering Keywords: multi-parameter 1; multi-objective 2; genetic algorithms 3; water jet pump 4; impellers 5; optimal design 6.

Online: 27 July 2023 (08:36:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1314.v1

Maximizing Energy Efficiency and Daylight Performance in Office Buildings in BIM through RBFOpt Model-Based Optimization: The GENIUS Project

Julia Ratajczak, Dietmar Siegele, Elias Niederwieser

Subject: Engineering, Architecture, Building And Construction Keywords: RBFOpt model-based optimization; genetic algorithms; multi-objective optimization; Energy Use Intensity optimization; spatial Daylight Autonomy optimization; office building; layout optimization

Online: 18 May 2023 (09:37:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0481.v1

IRAPs in Combination with Highly Informative ISSRs Confer Effective Potentials for Genetic Diversity and Fidelity Assessment in Rhododendron

Sulin Wen, Hong Zhao, Manying Zhang, Guang Qiao, Xiaohui Shen

Subject: Biology And Life Sciences, Plant Sciences Keywords: genetic fidelity; genetic diversity; IRAP; ISSR; Rhododendron

Online: 28 March 2023 (09:56:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1357.v1

Revisiting Classical Controllers Design and Tuning with Genetic Programming

Carlos A. García, Manel Velasco, Cecilio Angulo, Pau Marti, Antonio Camacho

Subject: Engineering, Control And Systems Engineering Keywords: genetic algorithm; genetic programming; control design; control tuning

Online: 22 November 2023 (07:49:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1532.v1

Adapt the Parameters of RBF Networks Using Grammatical Evolution

Ioannis G. Tsoulos, Alexandros Tzallas, Evangelos Karvounis

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Neural networks; Genetic algorithms; Genetic programming; Grammatical evolution

Online: 22 September 2023 (08:37:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0583.v1

A Systematic Review on Extreme Phenotype Strategies to Search for Rare Variants in Genetic Studies of Complex Disorders

Sana Amanat, Teresa Requena, Jose Antonio Lopez-Escamez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic association studies; extreme phenotype; genetic epidemiology; tinnitus

Online: 24 July 2020 (13:43:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1729.v1

Assessment of Diversity and Genetic Variability of Guava (Psidium guajava) by Means of Microsatellite Markers in Montería, Córdoba-Colombia

Enrique Pardo-Perez, Elizabeth Ramos-Rivero, Luis Causil-Vargas

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic diversity; genetic variability; microsatellites; allele frequencies; population structure

Online: 28 November 2023 (08:08:48 CET)

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Working Paper ARTICLE

Operationalising Forensic Genetic Genealogy in an Australian Context

Nathan Scudder, Runa Daniel, Jennifer Raymond, Alison Sears

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: forensic genetic genealogy; investigative genetic genealogy; DNA; forensic DNA

Online: 1 August 2020 (16:29:22 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202011.0387.v1

Genetic Music: When Genes Code for Melodies Instead of Proteins

Marga Consortium, Blanca A. Gutierrez, Iván Aitor Lucas del-Amo, Beatriz Alejos Bermudez, Cristina Gonzalez Moran, Veronica Noval Gutierrez, Borja Sanchez

Subject: Social Sciences, Anthropology Keywords: genetic music; genetic code; music composition; steam disciplines; notch1 gene

Online: 13 November 2020 (15:34:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0047.v1

Genetic Structure and Eco-Geographical Differentiation of Wild Sheep Fescue (Festuca ovina L.) in Xinjiang, Northwest China

Chenglin Zhang, Jianbo Zhang, Yan Fan, Ming Sun, Wendan Wu, Wenda Zhao, Xiaopeng Yang, Linkai Huang, Yan Peng, Xiao Ma, Xinquan Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Festuca ovina L.; AFLP, genetic diversity; genetic barriers; environmental factors

Online: 18 July 2017 (10:05:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0738.v1

Utility of Whole-Exome Sequencing in Pediatric and Medical Diagnosis

Mohd Fareed, Varun Sharma, Hemender Singh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Next generation sequencing; Genetic disorders; Genomic medicine; Genetic counseling; Rare diseases

Online: 29 December 2020 (16:47:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0144.v1

Genetic Environments of Plasmid-Mediated bla_CTXM-15beta-lactamase gene in Enterobacteriaceae from Africa

Babafela Awosile, Michael Agbaje

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Antimicrobial resistance; blaCTX-M-15; genetic environment; mobile genetic elements; Africa

Online: 7 December 2020 (12:49:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1185.v1

Genetic regulation of human isomiR biogenesis

Guanglong Jiang, Jill L. Reiter, Chuanpeng Dong, Yue Wang, Fang Fang, Zhaoyang Jiang, Yunlong Liu

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: microRNA; isomiR; genetic association

Online: 18 July 2023 (07:52:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0710.v1

Genetic Algorithm Based Feature Selection Technique for Optimal Intrusion Detection

Sydney Mambwe Kasongo

Subject: Engineering, Automotive Engineering Keywords: Intrusion Detection; Genetic Algorithm

Online: 29 June 2021 (13:30:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0276.v1

Genetic Variation of Traits in Natural Enemies Relevant for Biological Control: A Systematic Review

Kim B. Ferguson, Sophie R. Chattington, Wouter N. Plouvier, Bart A. Pannebakker

Subject: Biology And Life Sciences, Insect Science Keywords: genetic improvement; genetic variation; heritability; systematic review; biocontrol agent; life history traits

Online: 24 January 2020 (10:39:55 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0328.v1

The Effect of Pathogenic Tumor Suppressor Gene Variants on COVID-19: A Report of Three Cases with Varied Severity and Outcomes

Rostislav K. Skitchenko, Yury A. Barbitoff, Mikhail A. Fedyakov, Anna Yu. Anisenkova, Sergei V. Mosenko, Svetlana V. Apalko, Andrey S. Glotov, Oleg S. Glotov, Sergey G. Shcherbak

Subject: Biology And Life Sciences, Other Keywords: COVID-19; SARS-CoV-2; oncology; genetic variants; NGS; severity; genetic associations; exome

Online: 6 December 2023 (08:52:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0099.v1

Genetic Parameters of Growth Traits and Quantitative Genetic Metrics for Selection and Conservation of Mecheri Sheep of Tamil Nadu

B. Balasundaram, A.K. Thiruvenkadan, N. Murali, J. Muralidharan, D. Cauveri, Sunday O. Peters

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Genetic parameters, (Co)variance components, Mecheri sheep, Animal models, Maternal genetic influence, Inbreeding

Online: 6 December 2022 (10:03:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0509.v1

Genetic Variation of Native Perilla Germplasms Collected from South Korea Using SSR Markers and Morphological Characteristics

Jun Seok Oh, Kyu Jin Sa, Hyeon Park, Do Yoon Hyun, Sookyeong Lee, Ju-Hee Rhee, Ju Kyong Lee

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Perilla crop; genetic resources; morphological traits; principal component analysis; SSR marker; genetic variation

Online: 22 July 2021 (08:04:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0706.v2

Dr Jekyll and Mr Hyde: From Two Branches of Immune Response to Three Types of Interferon Response

Brent Brown, Chinua Imarogbe, Ingo Fricke, Pascal Mensah

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Interferon; Innate; Adaptive; Genetic; Molecular

Online: 26 September 2023 (11:35:53 CEST)

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Interferons were the original prototype cytokine system discovered in 20th-century research. As the name implies, they were originally thought to be synthesised and secreted between cells. Thanks to technological advances, the processes involved in protein secretion can be explained comparatively more clearly at both the genetic and biochemical levels. The discovery of interferon (IFN) occurred when genetic research was still in its infancy. Franklin and Wilkins discovered the structure and function of deoxyribonucleic acid (DNA) at the same time as Crick and Watson; however, Isaacs and Lindemann, two scientists, described the first IFN in 1957. Mutations can be caused by inherent genetic protein synthesis and during infection as well as within IFN regulation pathways affecting cell proliferation. This remains central to host cell IFN synthesis and effects through IFN protein receptor subunits defined by 6 protein domains. Type II IFN is key to immune cell function secreted by a variety of immune cells, mainly natural killer (NK) as well as T cells. Single–stranded and/or double–stranded RNA/DNA viruses, as well as bacterial infections (e.g., Escherichia coli) and fungal infections (e.g., Aspergillus), also affect IFN regulation. Pathogenic proteins utilise intra/extracellular proteins that sense foreign antigens like Toll–like Receptors (TLRs), affected by mutations within the human cellular IFN transduction pathways. Since the discovery of the third IFN type in 2003, when immune cell phenotypes were further characterised, questions remain about the immunological mechanisms contributing to the regulation of the innate and adaptive host immune system. Alterations in the synthesis of type I/II/III host IFNs can differentially and beneficially alter homeostatic cellular pathways in pathological disease, with type I IFN being synthesised in cancer as well as by homeostatic cells. Therefore, considered here are the overall IFN molecular, cell regulatory mechanisms in the context of immune cell research developments.

Preprint CASE REPORT | doi:10.20944/preprints202306.0239.v1

Optimal Evaluation of Left Ventricular Hypertrophic Phenotype Using Parametric CMR Mapping and Genetic Testing

Andrés Felipe Barragán-Amado, Jaime A Parra, María C Manzur, Julian A Gelves-Meza, Claudia P Jaimes, María F Tamayo, Héctor M Medina, María Juliana Rodríguez-González

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiomyopathy; Genetic disorders; Cardiovascular Imagen

Online: 5 June 2023 (05:02:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0114.v1

Genetic Determinants of Atherogenic Indexes

Tomas Texis, Susana Rivera-Mancia, Eloisa Colin-Ramirez, Raul Cartas-Rosado, David Koepsell, Kenneth Rubio-Carrasco, Mauricio Rodriguez-Dorantes, Vanessa Gonzalez-Covarrubias

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Dyslipidemia; atherogenic indexes; genetic associations

Online: 7 April 2023 (05:24:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1960.v1

Directional Breeding Generates Distinct Genetic Diversity in Hybrid Turf Bermudagrass as Probed with SSR Markers

Desalegn D. Serba, Tilin Fang, Yanqi Wu

Subject: Biology And Life Sciences, Plant Sciences Keywords: C. dactylon; C. transvaalensis; interspecific hybrids; cluster analysis; genetic similarity; genetic diversity; directional breeding

Online: 29 May 2023 (08:55:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0021.v1

Protein 0^th-Order Structure: The Key for Creating Entirely New Gene/Protein

Kenji Ikehara

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein 0th-order structure; origin of gene; origin of protein; origin of genetic code; GNC primeval genetic code hypothesis; SNS primitive genetic code hypothesis

Online: 3 December 2019 (11:10:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0169.v1

The Supersymmetry Genetic Code Table and Quadruplet Symmetries of DNA Molecule Are the Unchangeable and Synchronized with the Codon Free Energy Mapping during Evolution

Marija Rosandic, Vladimir Paar

Subject: Biology And Life Sciences, Other Keywords: genetic code symmetry, mitochondrial genetic code, energy code, DNA quadruplet symmetry, classification of trinucleotides/codons

Online: 4 October 2023 (07:43:22 CEST)

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The Supersymmetry Genetic code (SSyGC) table is based on five physicochemical symmetries: 1) double mirror symmetry on the principle of the horizontal and vertical mirror symmetry axis between all bases (purines [A, G) and pyrimidines (U, C)], and 2) of bases in form of codons 3) direct – complement like codon/anticodon symmetry in the sixteen alternating boxes of the genetic code columns, 4) A+T rich and C+G rich alternate codons in the same row between both columns of the genetic code, 5) the same position between divided and undivided codon boxes in relation to horizontal mirror symmetry axes. The SSyGC table has a unique physicochemical purine – pyrimidine symmetry net which is as the core symmetry common for all, more than thirty different nuclear and mitochondrial genetic codes. This net is present in the SSyGC table of all RNA and DNA living species. None of these symmetries is present in the Standard Genetic Code (SGC) table which is constructed on the alphabetic horizontal and vertical U-C-A-G order of bases. Here we show that the free energy value of each codon incorporated as fundamentally mapping the “energy code” in the SSyGC table is compatible with mirror symmetry. On the other hand, in the SGC table the same free energy values of codons are dispersed and a mirror symmetry between them is not recognizable. At the same time the mirror symmetry of the SSyGC table and the DNA quadruplets together with our classification of codons/trinucleotides are perfectly imbedded in the mirror symmetry energy mapping of codons/trinucleotides and point out in favor of maintaining the integrity of the genetic code and DNA genome. We also argue that physicochemical symmetries of the SSyGC table in the manner of the purine – pyrimidine symmetry net, the quadruplet symmetry of DNA molecule and the free energy of codons have remined unchanged during all of evolution. The unchangeable and universal symmetry properties of the genetic code, DNA molecule and energy code are decreasing disorder between codons/trinucleotides and shed a new light on evolution. Diversity in all living species on Earth is broad, but the symmetries of the Supersymmetry Genetic Code as the code of life and the DNA quadruplets related to the” energy code” are unique, unchangeable and have the power of natural laws.

Preprint ARTICLE | doi:10.20944/preprints202212.0234.v1

History of Advances in Genetic Engineering of Viruses Prior to COVID-19 Pandemic

Mikhail Teppone

Subject: Biology And Life Sciences, Virology Keywords: reassortant virus; recombinant virus; chimeric virus; genetic engineering; reverse genetic; SARS-CoV-2; COVID-19

Online: 13 December 2022 (08:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0274.v1

Constructing the Bounds for Neural Network Training Using Grammatical Evolution

Ioannis G. Tsoulos, Alexandros Tzallas, Evangelos Karvounis

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Neural networks; Genetic algorithms; Grammatical Evolution

Online: 5 October 2023 (10:59:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1482.v1

Comparative Proteomic Analysis of Toxoplasma gondii Rh Wild-type and Four SRS29B (SAG1) Knock-Out Clones Reveals Significant Differences Between Individual Strains

Kai Pascal Alexander Hänggeli, Andrew Hemphill, Norbert Müller, Manfred Heller, Uldry Anne-Christine, Sophie Braga-Lagache, Joachim Müller, Ghalia Boubaker

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic manipulation; pleiotropic effects; systems biology

Online: 22 May 2023 (09:03:52 CEST)

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In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a suitable tool to identify the role of specific genes. The general consensus implies that only the gene of interest is affected by the knock-out. Is this really the case? In a previous study, we have generated knock-out (KO) clones of TgRH88_077450 (SRS29B; SAG1) which differed in the numbers of integrated dihydrofolate-reductase-thymidylate-synthase (MDHFR-TS) drug-selectable marker. Clones 18 and 33 had a single insertion of MDHFR-TS within SRS29B. Clone 6 was disrupted by the insertion of a short unrelated DNA-sequence, but the marker was integrated elsewhere. In clone 30, the marker was inserted into SRS29B and several other MDHFR-TS copies were found in the genome. KO and wild-type (WT) tachyzoites had similar shape, dimensions and vitality. This prompted us to investigate the impact of the genetic engineering as such on the overall proteome patterns of the four clones as compared to the respective WT. Comparative shotgun proteomics of the five strains was performed. Overall, 3236 proteins were identified. Principal component analysis of the proteomes revealed five distinct clusters corresponding to the five strains by both iTop3 and iLFQ algorithms. Detailed analysis of the differentially expressed proteins revealed that the target of the KO, srs29B, was lacking in all KO clones. Besides this protein, twenty other proteins were differentially expressed between KO clones and WT or between different KO clones. The protein exhibiting the highest variation between the five strains was srs36D encoded by TgRH_016110. The deregulated expression of SRS36D was further validated by quantitative PCR. Moreover, the transcript levels of three other selected SRS genes, namely SRS36B, SRS46, and SRS57 exhibited significant differences between individual strains. These results indicate that knocking out a given gene may affect the expression of other genes. Therefore, care must be taken when specific phenotypes are regarded as a direct consequence of the KO of a given gene.

Preprint ARTICLE | doi:10.20944/preprints202201.0414.v1

Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions

Deiviane Calegar, Beatriz Nunes, Kerla Monteiro, Polyanna Bacelar, Brenda Evangelista, Mayron Moraes, Jurecir Silva, Jéssica Santos, Márcio Bóia, Lauren Jaeger, Filipe Anibal Carvalho-Costa

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Giardia duodenalis; Assemblages; Epidemiology; Genetic diversity

Online: 27 January 2022 (11:18:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0533.v1

Unlocking the Complete Chloroplast Genome of a Native Tree Species from the Amazon Basin, Capirona (Calycophyllum spruceanum Benth., Rubiaceae), and Its Comparative Analysis with Other Ixoroideae Species

Carla L. Saldaña, Pedro Rodriguez-Grados, Julio C. Chávez-Galarza, Shefferson Feijoo, Juan Carlos Guerrero Abad, Héctor V. Vásquez, Jorge L. Maicelo, Jorge H. Jhoncon, Carlos I. Arbizu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chloroplast; genetic resources; genomics capirona; phylogenomics

Online: 29 November 2021 (12:32:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0692.v1

Use of Genetic Algorithms to Optimize Efficiency in Small-Scale Structures

Aaron Chew

Subject: Engineering, Civil Engineering Keywords: Genetic algorithms, structures, algorithms, generative design

Online: 29 March 2021 (12:50:16 CEST)

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Working Paper ARTICLE

Evaluation of the Gene Flow From East to West among Various Populations of Rajasthan, India

R.K. Kumawat, Pankaj Shrivastava, Shivani Dixit, Divya Shrivastava, G.K. Mathur, Gyaneshwer Chaubey

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Genetic affinity; STR; Rajasthan; Heterozygosity; Polymorphic

Online: 21 June 2020 (14:12:03 CEST)

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Working Paper REVIEW

Physicochemical Foundations of Life that Direct Evolution. Why Chance and Natural Selection cannot Explain Evolution

Didier Auboeuf

Subject: Biology And Life Sciences, Biophysics Keywords: evolution; genetic code; RNA; protein; physicochemistry

Online: 28 November 2019 (09:38:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0349.v1

Genetic Diversity of Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae) Colonizing Sweet Potato and Cassava in South Sudan

Beatrice Clarence Misaka, Everlyne N. Wosula, Philip W. Marchelo-d'Ragga, Trine Hvoslef-Eide, James Peter Legg

Subject: Biology And Life Sciences, Forestry Keywords: Bemisia tabaci; genetic diversity; distribution; haplotype

Online: 28 November 2019 (03:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0201.v1

The Critical Needs and Challenges for Genetic Architecture Studies in Africa

Alicia R. Martin, Solomon Teferra, Marlo Möller, Eileen G. Hoal, Mark J. Daly

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic architecture; Africa; GWAS; health disparities

Online: 13 June 2018 (11:17:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1951.v1

Groups of Symmetries of the Two Classes of Synthetases in the Four-Dimensional Hypercubes of the Extended Code Type II

Marco V. José, Eberto R. Morgado, Juan R. Bobadilla

Subject: Biology And Life Sciences, Life Sciences Keywords: Aminoacyl-tRNA synthetases; Standard Genetic Code; Symmetry groups; Origin and evolution of the genetic code; Group Theory

Online: 29 August 2023 (08:34:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0827.v1

AI-Based Procedure for the Assessment of Voice Characteristics in Genetic Syndromes

Federico Calà, Lorenzo Frassineti, Elisabetta Sforza, Roberta Onesimo, Lucia D’Alatri, Claudia Manfredi, Antonio Lanata, Giuseppe Zampino

Subject: Engineering, Bioengineering Keywords: Genetic syndrome; Acoustical analysis; Artificial Intelligence; Classification

Online: 12 October 2023 (12:03:32 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202309.1918.v1

Isoniazid-Resistant Tuberculosis—A Series of Clinical Cases

Teodora Butnaru, Florin Dumitru Mihaltan, Ancuta Alina Constantin

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: multidrug-resistant tuberculosis; genetic mutations; clinical cases.

Online: 28 September 2023 (08:02:58 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.1060.v1

Rare and Complex Cardiac Anomalies Associated with 22q11.2 Deletion: An Ultrasonographic Visual Trip from Diagnosis until Delivery

Radu Vlădăreanu, Călina Maier, Raluca Tocariu, Marcela Șerban, Elvira Brătilă

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: interrupted aortic arch; 22q11.2DS; ultrasound; genetic tests

Online: 18 September 2023 (05:41:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0697.v1

Selection of Short-Day Strawberry Genotypes through Multivariate Analysis

Thiago Rutz, Juliano Tadeu Vilela de Resende, Keny Henrique Mariguele, Ricardo Antônio Zeist, Andre Luiz Biscaia Ribeiro da Silva

Subject: Biology And Life Sciences, Horticulture Keywords: Fragaria × ananassa; genetic parameters; selection index; clusterin

Online: 11 July 2023 (08:40:08 CEST)

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Strawberry is produced in tropical regions using imported cultivars adapted to temperate and subtropical climates. These cultivars, under tropical conditions, produce below their genetic potential. Through multivariate analyses, the objective was to evaluate and select short-day strawberry genotypes based on intraspecific crosses, product characteristics, and fruit quality. The genotypes were obtained from the cross between 'Camino Real' (female parent) and the first-generation genotypes RVCA16, RVCS44, RVFS06, RVFS07, and RVDA11 (male parent), obtained in previous selections. The experimental design consisted of augmented blocks with standard controls, consisting of first-generation genotypes and commercial cultivars. The fruits were harvested and evaluated for productivity and post-harvest characteristics: Total Fruit Mass (MTF); Total Number of Fruits (TFN); Average Fruit Mass (AFM); Commercial Fruit Mass (CFM); Fruit Commercial Number (CFN); Average Commercial Mass of Fruits (ACFM); Total Soluble Solids (TSS); Firmness (F); Brightness (L); Hue Angle (°Hue); Chroma (C). The selection index of Mulamba and Mock (1978) was used with an intensity of 3% to obtain superior genotypes and submitted to multivariate analysis for comparative purposes. Of the 1500 genotypes evaluated, it was possible to select 44 genotypes with characteristics superior to the 13 controls. The RVDA11CR59 genotype showed better values for the attributes of interest, but the RVCS44CR population, from the cross between 'Camino Real' × RVCS44 ('Camarosa' × 'Sweet Charlie'), obtained the highest number (16) of individuals among those selected. Significant traits had high heritability but were not necessarily reflected in high selection gain. Coefficients of genetic variation were high, indicating sufficient genetic variability to select genotypes for these traits. When multivariate analyses were used, it was possible to group the selected genotypes into the same cluster according to the similarity and balance in the responses to the evaluated variables, demonstrating that these analyses help other parameters choose superior genotypes. The multivariate analysis allowed the selection of more balanced genotypes for production and post-harvest traits for tropical climates.

Preprint ARTICLE | doi:10.20944/preprints202306.0020.v1

Genetic Drift and Alphapapillomavirus Evolution

Robert D. Burk, Lisa Mirabello, Robert DeSalle

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: molecular evolution; genetic drift; human papillomavirus (HPV)

Online: 1 June 2023 (03:52:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1634.v1

Genotypic and Sanitary Characterization of Minority Grapevine Varieties Prospected in Andalusia, Spain

Inmaculada Rodríguez-Torres, Ana Martín Carrillo, María del Pilar Ramírez, Francisco Jesus Gómez Gálvez, Leonardo Velasco Arjona, Carlos Padilla, Enrico Cretazzo

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: genetic resources; molecular markers; local cultivar; certification

Online: 23 May 2023 (09:55:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1454.v1

Relevance of Genetic Identification and Kinship Analysis in Human and Natural Catastrophes – A Review

Alejandra Real-Picado, Luis Diaz, Cláudia Gomes

Subject: Medicine And Pharmacology, Other Keywords: Catastrophes; Genetic identification; Kinship analysis; DNA degradation

Online: 22 May 2023 (03:01:25 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0087.v1

Recent Population Dynamics of Japanese Encephalitis Virus

Jinpeng Xu, Abdul Wahaab, Sawar Khan, Mohsin Nawaz, Muhammad Naveed Anwar, Ke Liu, Jianchao Wei, Muddassar Hameed, Zhiyong Ma

Subject: Biology And Life Sciences, Virology Keywords: Japanese encephalitis virus; Population dynamic; Genetic diversity

Online: 2 May 2023 (11:02:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0505.v1

Tomato Defence Suppression is a Common Trait in Tetranychus urticae Collected from Field-Grown Tomatoes

Jéssica Teodoro-Paulo, Carlos Fernandes, Lin Dong, Sara Magalhães, Alison B. Duncan, Juan M. Alba, Merijn R. Kant

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: phylogeny; salivary effectors; effector 84; genetic diversity

Online: 28 February 2023 (04:44:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0305.v1

National and Ethnic Mutation Frequency Databases: Cross Comparison and Future Direction

Shumaila Khan, Mehmood Alam, Shahnaz Khan, Wahab Khan, Ihsan Rabbi, Iqbal Qasim

Subject: Computer Science And Mathematics, Information Systems Keywords: genetic databases; mutation disorders; ethnic specific databases

Online: 17 February 2023 (07:59:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0197.v1

Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review

Juan Angel Garcia-Quiñones, Celia Nohemi Sanchez-Dominguez, María Fernanda Serna-Rodríguez, Ivan Alberto Marino-Martinez, Ana María Rivas-Estilla, Antonio Alí Pérez-Maya

Subject: Social Sciences, Behavior Sciences Keywords: Biomarkers; Genetic; Suicidal behavior; Suicide; Mexican; Genomic.

Online: 11 January 2023 (10:34:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0400.v1

The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients

Marica Meroni, Miriam Longo, Erika Paolini, Anna Alisi, Luca Miele, Emilia Rita De Caro, Giuseppina Pisano, Marco Maggioni, Giorgio Soardo, Luca Vittorio Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Lipid metabolism; NAFLD; genetic variants; PSRC1; HCC

Online: 15 March 2021 (16:30:15 CET)

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Working Paper CONCEPT PAPER

The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype

Didier Auboeuf

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: evolution; darwinism; genetic code; RNA; homoestasis; physics

Online: 6 January 2021 (15:06:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0003.v2

Non-Homologous end Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population

Raquel Gago-Fuentes, Valentyn Oksenych

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA repair; NHEJ; synthetic lethality; genetic interaction

Online: 15 December 2020 (10:41:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0653.v1

DetR DB: A Database of Ionizing Radiation Resistance Determinants

Alina Ryabova, Olga Kozlova, Azat Kadirov, Oleg Gusev, Elena Shagimardanova

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ionizing radiation; radiation resistance; genetic mechanisms; microorganisms

Online: 26 September 2020 (17:24:56 CEST)

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Working Paper HYPOTHESIS

Human Genetic Diversity Possibly Determines Human's Compliance to COVID-19

Yiqiang Zhao, Yunchun Gu, Yongji Liu, Sa Li, Yuzhan Wang, Lina Bu, Qi Liu, Hongyi Lv, Fang Wan, Lida Wu, Zemin Ning

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; severe symptoms; inactivation; genetic diversity

Online: 16 April 2020 (09:15:49 CEST)

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Working Paper ARTICLE

Assessment of Genetic Diversity of Dioscorea praehensilis (Berth.) Collected from Central Region, Ghana Using Simple Sequence Repeat (SSR) Markers

Adeyinka S. Adewumi, Kingsley J. Taah, Paul A. Asare, Michael O. Adu, Paterne A. Agre

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic diversity; Dioscorea praehensilis; SSR markers; Ghana

Online: 8 March 2020 (14:55:19 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201912.0176.v1

A Framework for Maximising the Capture of Genetic Diversity in Sampling for ex situ Conservation

Linda Neaves

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: conservation; genetic diversity; decision-making; ex situ

Online: 12 December 2019 (12:43:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0046.v1

Stimulation of Replication Template-Switching by DNA-Protein Crosslinks

Laura T. Laranjo, Julie A. Klaric, Susan T. Lovett

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA replication, DNA repair, genetic recombination, mutagenesis

Online: 2 November 2018 (10:19:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0089.v1

The Importance of a Multidisciplinary Approach in the Management of a Patient with Type I Gaucher Disease

Miguel-Ángel Torralba-Cabeza, Susana Olivera-González, José-Luis Sierra-Monzón

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: multidisciplinary; Gaucher; genotype/phenotype correlation; genetic counselling

Online: 5 July 2018 (08:51:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0329.v1

Ethical, Legal and Social Implications of Susceptibility Genetic Testing for Late-Onset Neurodegenerative Diseases

Amaranta Manrique de Lara, Elisa Núñez-Acosta, Garbiñe Saruwatari-Zavala, Liliana Soto-Gómez, Miguel E. Rentería

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; Parkinson’s disease; Genetic testing; bioethics

Online: 21 June 2018 (04:38:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0191.v1

Recent Developments in Using Drosophila as a Model for Human Genetic Disease

Christine Oriel, Paul Lasko

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: rare disease; functional genomics; genetic variant validation

Online: 12 June 2018 (12:36:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0215.v1

Estimation of Genetic Parameters and Prediction of Genotypic Values in Common Beans Using Mixed Models

Jessica Delfini, Vania Moda Cirino, Claudete de Fátima Ruas, Paulo Mauricio Ruas, José dos Santos Neto, Leandro Simões Azeredo Gonçalves

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Phaseolus vulgaris L.; REML/BLUP; genetic diversity

Online: 26 March 2018 (10:35:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0005.v1

Improved Forms for Controlling the Acrobot with Motors of Atypical Size Using Artificial Intelligence Techniques

Gonzalo Mier, Javier de Lope

Subject: Engineering, Control And Systems Engineering Keywords: Acrobot; Artificial Intelligence; SARSA; PWM; Genetic Algorithm

Online: 4 July 2017 (16:12:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1015.v1

DDoS classification to SDN using Grammatical Evolution

Evangelos Spyrou, Ioannis Tsoulos, Chrysostomos Stylios

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: SDN; DDoS; genetic algorithm; Grammatical Evolution; packet classification

Online: 16 November 2023 (03:03:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0243.v1

Lupinus mutabilis Breeding in the Andes of Ecuador, Peru, and Bolivia: A Review

Diego Rodriguez-Ortega, José Luis Zambrano, Santiago Pereira-Lorenzo, Andres Torres, Angel Murillo

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Lupinus mutabilis; genetic diversity; breeding; anthracnose resistance; alkaloids

Online: 5 October 2023 (02:38:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0463.v1

Investigations of 13 Genes in Non-Cicatricial Alopecia

Monica Păun, Gustavo Torres, George Sorin Țiplica, Victor Mihail Cauni

Subject: Medicine And Pharmacology, Dermatology Keywords: alopecia areata; androgenetic alopecia; genetic test; DNA analysis

Online: 7 August 2023 (10:13:57 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202306.2051.v1

Genetic Structure and Biodiversity in Wild Centropomus Parallelus and in Wild and Recently Domesticated Centropomus Undecimallis Populations

Marcos Edgar Herkenhoff, Miklos Maximiliano Bajay, Carlos André da Veiga Lima-Rosa Costamilan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Microsatellites; Centropomus parallelus; Centropomus undecimalis; Centropomidae, genetic polymorphism

Online: 28 June 2023 (15:31:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1721.v1

Characteristics of Seismogenic Dust Particles from Mountain and Its Significance for Paleoseismic Records in Tufa Section: A Case Study of Jiuzhaigou, China

Shengwen Jing, Fudong Wang, Enrico Capezzuoli, Guoqing Huang, Junhao Li, Hanchao Jiang, Zijian Zhou, Xueqin Zhao, Faqin Dong, Andrea Brogi

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Jiuzhaigou; Tufa particulate matter; Sedimentation; Genetic analysis; Paleoearthquake

Online: 25 June 2023 (07:11:39 CEST)

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The sedimentary characteristics of the special interlayer contained in the section of the Sparking Lake dam revealed by the 8.8 Jiuzhaigou earthquake in 2017 are obviously different from the tufa in the dam body, and they are considered to be prehistoric flood relics. Based on the study of the particulate matter from the 8.8 Jiuzhaigou earthquake, this paper combines comparative petrographic, mineralogical, geochemical and chronological studies of the special interbedded sediments of the Sparking Lake dam with other genetic samples to obtain homology information and genetic links, as well as to explore the tufa depositional dynamics and earthquake disaster subsidence. The palaeoseismic benefit in the discontinuity layer is explored, and the palaeoseismic information embedded in the profiles is extracted, providing a new idea to reconstruct the palaeoseismic events in the tufa deposition sequence. According to X-ray diffraction, laser particle size analysis and scanning electron microscope experiments, the particulate matter in the Jiuzhaigou mountains has its own specific mineralogical characteristics. The mineral composition of the particulate matter is basically calcite. The particle size is large, and the single particle is mostly angular and subangular. The fracture morphology observed under the single particle microscope is uneven, showing the characteristics of dust caused by earthquake disasters. Geochemical analysis data show that the provenance of various types of particles in the same area is stable, indicating the homology of terrestrial carbonate sedimentation in the karst system. Combined with mineralogy and grain size morphology, the interbedded particles in the tufa depositional profile have the potential application of palaeoseismic archives to record extreme seismic events. The palaeoseismic date was inferred from the chronological data of special interlayered sediments in the tufa dam body. Therefore, the tufa bedding can be related to the palaeoearthquake, and the special interlayer of the tufa section can be used to reconstruct palaeoearthquakes.

Preprint ARTICLE | doi:10.20944/preprints202306.0613.v1

Assessment of Genetic Diversity in Winged Bean [Psophocarpus Tetragonolobus (L.) DC.] Accessions Using Morphological Traits and Microsatellite Markers

Temitope Esther Olatunde, Adeolu Moses Adebayo, Ayomide Ajoke Bhadmus, Idris Ishola Adejumobi, Olaniyi Oyatomi, Benjamin Faloye, Michael Abberton

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Accessions; genetic diversity; morphological traits; SSRs; winged bean

Online: 8 June 2023 (09:25:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0016.v1

The IFIH1/MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early Versus Late-Onset Skin Disease and Increased the Risk of Arthritis in a Spanish Cohort of Psoriatic Disease

Pablo Coto-Segura, Daniel Vazquez-Coto, Lucinda Velazquez-Cuervo, Claudia García-Lago, Eliecer Coto, Rubén Queiro

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; psoriatic arthritis; IFIH1; MDA5; polymorphism; genetic association

Online: 1 June 2023 (03:40:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1297.v1

Recent Advances in Elucidating the Mechanism Underlying Proteinuric Kidney Disease/Nephrotic Syndrome: Lessons From Knockout/Transgenic Mouse Models

Ryosuke Saiki, Kan Katayama, Kaoru Dohi

Subject: Medicine And Pharmacology, Other Keywords: genetic kidney disease; knockout; nephrotic syndrome; proteinuria; transgenic

Online: 18 May 2023 (08:10:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1095.v1

Chromosome-Level Genome Assembly and Population GE-Nomic Analyses Reveal Geographic Variation and Population Genetic Structure of Prunus tenella

Yue Qin, Han Zhao, Hongwei Han, Gaopu Zhu, Zhaoshan Wang, Fangdong Li

Subject: Biology And Life Sciences, Horticulture Keywords: Prunus tenella; genome; assembly; almond; population genetic structure

Online: 16 May 2023 (05:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1057.v1

Genetic Polymorphisms of ACE1 rs4646994 Associated with Lung Cancer in Patients with Pulmonary Nodules: A Case Control Study

Rong Qiao, Siyao Sang, Jiajun Teng, Hua Zhong, Hui Li, Baohui Han

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic polymorphism; ACE1 rs4646994; lung cancer; pulmonary nodules

Online: 27 April 2023 (07:47:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0453.v1

Genetics of Resistance to Leaf Rust in Wheat: An Overview in A Genome-Wide Level

Xiaopeng Ren, Chuyuan Wang, Zhuang Ren, Jing Wang, Peipei Zhang, Shuqing Zhao, Mengyu Li, Meng Yuan, Xiumei Yu, Zaifeng Li, Shisheng Chen, Xiaodong Wang

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: wheat; resistance; leaf rust; genetic loci; genome-wide

Online: 23 December 2022 (08:11:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0427.v1

Composition and Patterns of Taxa Assemblages in the Western Channel Assessed by 18S Sequencing, Microscopy and Flow Cytometry

Stern Rowena, Kathryn Picard, Jessica Clarke, Charlotte Walker, Claudia Martins, Clare Marshall, Ana Amorim, Malcolm Woodward, Claire Widdicombe, Glen Tarran, Martin Edwards

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Plankton; Monitoring; Harmful algae; microscopic; genetic; Western Channel

Online: 22 December 2022 (11:34:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0210.v1

Impact of Drought on Maize Yield and Exploration of In-Situ Maize Crop Genetic Resources for Drought Tolerance.

G MAHENDRA SINGH, Gokul Gosavi, Srinathareddy S, Shiv Shankar Patel, Pawan Singh Solanki, Feng Zhang, Jianchu Xu, V K Mishra, Sandeep Sharma

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Maize; drought; landrace; climate-change; crop genetic resources

Online: 13 December 2022 (01:07:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0244.v1

Screening Aromatic Rice Genotypes by RAPD Markers for Breeding Salinity Stress Tolerant Rice Variety

Md Abdul Azim, Md Mahbubur Rahman, Dipali Rani Gupta, Aniruddha Sarker, Tofazzal Islam

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aromatic rice; salt screening; RAPD marker; genetic diversity

Online: 14 November 2022 (07:43:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0106.v1

Chloroplast Genetics Engineering: from Bench to Blast Application of Chloroplast Genetic-Engineering in Basic Research

Bo Wang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Keywords: chloroplast genetic engineering; Homologus recombination; ORF; photosynthesis

Online: 7 November 2022 (04:31:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0332.v1

Getting the Full Picture of Plankton in the Western Channel

Stern Rowena, Kathryn Picard, Jessica Clarke, Charlotte Walker, Claudia Martins, Clare Marshall, Ana Amorim, Malcolm Woodward, Claire Widdicombe, Glen Tarran, Martin Edwards

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Plankton; Monitoring; Harmful algae; microscopic; genetic; Western Channel

Online: 22 July 2022 (03:33:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0331.v1

Visualizing the Complexity of Proteins in Living Cells With Genetic Code Expansion

Kanokpol Aphicho, Narongyot Kittipanukul, Chayasith Uttamapinant

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Genetic code expansion; unnatural amino acid; fluorescence imaging

Online: 21 December 2021 (12:42:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0334.v1

An Improved Nesting Algorithm for Irregular Patterns

German Martinez-Martinez, Jose-Luis Sanchez-Romero, Antonio Jimeno-Morenilla, Higinio Mora-Mora

Subject: Computer Science And Mathematics, Information Systems Keywords: Nesting; cutting; irregular pattern; genetic algorithm; smart manufacturing

Online: 22 October 2021 (15:41:54 CEST)

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