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Preprint ARTICLE | doi:10.20944/preprints202405.1663.v1

Genetic Algorithm based optimization of Clustering Algorithms for the Healthy Aging Dataset

Kahkashan Kouser, Amrita Priyam, Mansi Gupta, Sanjay Kumar, VANDANA BHATTACHARJEE

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Genetic Algorithms; Clustering; KMeans++; optimization

Online: 27 May 2024 (10:05:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0692.v1

Use of Genetic Algorithms to Optimize Efficiency in Small-Scale Structures

Aaron Chew

Subject: Engineering, Civil Engineering Keywords: Genetic algorithms, structures, algorithms, generative design

Online: 29 March 2021 (12:50:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0148.v1

Unconventional Luminaire Layout Design by Genetic Algorithms

Zuzana Panska, Marek Balsky, Rudolf Bayer, Michal Brejcha

Subject: Engineering, Electrical And Electronic Engineering Keywords: lighting design; genetic algorithm; luminaire layout design; luminous intensity curve

Online: 2 August 2024 (08:21:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1547.v1

Physics-Based Aircraft Dynamics Identification Using Genetic Algorithms

Raymundo Peña-García, Rodolfo Daniel Velázquez-Sánchez, Cristian Gómez-Daza-Argumedo, Jonathan Omega Escobedo-Alva, Ricardo Tapia-Herrera, Jesús Alberto Meda-Campaña

Subject: Engineering, Aerospace Engineering Keywords: Physical-based modelling; system identification; transition matrix; genetic algorithm.

Online: 20 December 2023 (13:49:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0079.v1

Performance Comparisons of Bio-micro Genetic Algorithms on Robot Locomotion

Francisco A. Chávez-Estrada, Jacobo Sandoval-Gutierrez, Juan C. Herrera-Lozada, Mauricio Olguín-Carbajal, Daniel L. Martínez-Vázquez, Miguel Hernández-Bolaños, Israel Rivera-Zárate

Subject: Engineering, Control And Systems Engineering Keywords: micro segmented genetic algorithm; multicore embedded system; parallel processing

Online: 5 March 2020 (03:23:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0172.v1

Oriented Crossover in Genetic Algorithms for Computer Networks Optimization

Furkan Rabee, Zahir M. Hussain

Subject: Computer Science And Mathematics, Computer Networks And Communications Keywords: Genetic Algorithm; Uniform Crossover; Network Protocol Optimization; Routing Algorithm; Optimization; Oriented Crossover

Online: 11 April 2023 (02:43:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0325.v1

Modelling, Parameters Identification and Experimental Validation of a Lead Acid Battery Bank Using Genetic Algorithms

Helbert Eduardo Ariza Chacón, Edison Banguero, Antonio Correcher, Ángel Pérez-Navarro, Francisco Morant

Subject: Engineering, Energy And Fuel Technology Keywords: modelling; lead-acid battery; parameter identification; genetic algorithms; experimental validation

Online: 18 August 2018 (06:14:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1263.v1

Genetic Algorithms Optimization of Beams in Terms of Maxim-Izing Gaps Between Adjacent Frequencies

Łukasz Domagalski, Izabela Kowalczyk

Subject: Engineering, Civil Engineering Keywords: genetic algorithms; optimization; band-gaps; beams; eigenproblem; dynamic analysis; finite element method

Online: 19 June 2023 (02:56:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0028.v1

Security-Constrained Optimal Dispatch of Combined Natural Gas and Electricity Networks Using Genetic Algorithms

Denis C. L. Costa, João Paulo Vieira, Marcus V. A. Nunes

Subject: Engineering, Energy And Fuel Technology Keywords: Integrated Electric Power and Natural Gas Network, Optimal Power Flow, Genetic Algorithm.

Online: 5 October 2017 (09:41:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0060.v1

Structural Optimization in Building Information Modeling (BIM) Projects Using Visual Programming, Evolutionary Algorithms, and Sustainability Assessment Tools

Feyzullah Yavan, Reza Maalek, Vedat Toğan

Subject: Engineering, Architecture, Building And Construction Keywords: Structural Optimization; Genetic Algorithm; Parametric Design; Visual Programming; Generative Modeling

Online: 2 April 2024 (12:41:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0130.v1

Metaheuristic Algorithms Based on Compromise Programming for Multi-Objective Urban Shipment Problem

Son Tung Ngo, Jafreezal Jaafar, Izzatdin Abdul Aziz, Muhammad Umar Aftab, Giang Hoang Nguyen, Ngoc Anh Bui

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: multi objective optimization; VRP; compromise programming; genetic algorithm; tabu search; local search; metaheuristics; combinatorial optimization

Online: 10 January 2022 (18:38:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0081.v1

Electric Power Grids Distribution Generation System For Optimal Location and Sizing – An Case Study Investigation by Various Optimization Algorithms

Ahmet Ali, Sanjeevikumar Padmanaban, Bhekisipho Twala, Tshilidzi Marwala

Subject: Engineering, Electrical And Electronic Engineering Keywords: optimization; simulated annealing; genetic algorithm; power losses; power consumption

Online: 9 May 2017 (10:45:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1745.v1

Optimized FIR Filter using Genetic Algorithms: A Case Study of ECG Signals Filter Optimization

Houssam Hamici, Awos Kanan, Khalid Al-hammuri

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: Genetic Algorithms; Digital Filters; Metaheuristic Optimization; Finite Impulse Response (FIR); Side Lobe Level (SLL).

Online: 24 August 2023 (10:46:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0637.v1

Enhanced Microgrid Control through Genetic Predictive Control: Integrating Genetic Algorithms with Model Predictive Control for Improved Non-Linearity and Non-Convexity Handling

Muhammed Cavus, Adib Allahham

Subject: Engineering, Electrical And Electronic Engineering Keywords: Genetic Algorithms (GA); Genetic Predictive Control (GPC); Energy management system (EMS); Microgrid (MG) control; Model Predictive Control (MPC); Non-linear systems

Online: 9 August 2024 (00:16:56 CEST)

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Microgrid (MG) control is essential for efficient, reliable, and sustainable energy management in distributed energy systems. Genetic Algorithm-based energy management systems (GA-EMS) can optimally control a MG by finding global optima and handling complex, non-linear, and non-convex problems, but they can be computationally intensive, making real-time control challenging. Model Predictive Control (MPC)-based EMS predicts future behaviour over a defined horizon, ensuring optimal performance and constraint satisfaction but typically relies on linear models. This paper proposes a novel Genetic Predictive Control (GPC) method, combining GA and MPC to enhance resource allocation, balance multiple objectives, and adapt dynamically to changing conditions. Integrating GA with MPC significantly improves the handling of non-linearities and non-convexity in the system model, leading to more accurate and effective control. Comparative analysis shows that GPC significantly reduces excess power production—surplus power generated beyond load demand—improving resource allocation efficiency. For instance, in the Mutation–Random Selection scenario, GPC reduced excess power to 76.0W compared to 87.0W with GA. Additionally, GPC balances cost, emissions, and power efficiency. In the Crossover-Elitism scenario, GPC achieved a daily cost of $113.94 compared to GA's $127.80, and carbon emissions of 52.83 kg CO2e compared to GA's 69.71 kg CO2e, demonstrating GPC's cost efficiency and environmental benefits. While MPC optimizes a weighted sum of objectives, designing appropriate weights can be challenging and may result in non-convex problems. GA handles multiple, conflicting objectives through multi-objective optimization, providing Pareto-optimal solutions. GPC's dynamic adaptability maintains optimal performance by forecasting future load demands and adjusting control actions. GPC consistently achieves lower emissions than GA across various scenarios and, although it sometimes incurs higher costs, such as $113.94 compared to $131.90 in the Crossover–Random Selection scenario, its holistic approach balances these costs with other metrics, making it cost-effective in the long run. By reducing excess power production and emissions, GPC contributes to economic savings and promotes sustainable practices. These findings underscore GPC's potential as a versatile, efficient, and environmentally beneficial optimization tool for power generation systems.

Preprint REVIEW | doi:10.20944/preprints202409.0531.v1

A Scoping Review of Genetic Algorithms in Serious Games: Applications, Challenges, and Future Directions

Vrushank Vaghani, Kiemute Oyibo

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: Mnemonics; Genetic Algorithms; Serious Games; Evolutionary Computation; Game Design; Optimization; Adaptive Learning; Personalized Learning; Evolutionary Algorithms

Online: 6 September 2024 (12:10:14 CEST)

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The integration of Genetic Algorithms (GAs) into Serious Games (SGs) has gained traction as a method to optimize game mechanics and personalize user experiences. While GAs are well-known for their effectiveness in solving complex optimization problems, their application in SGs remains relatively under-explored. This review aims to address this gap by systematically mapping the existing literature on the intersection of these two fields. The primary objective of this scoping review is to identify and synthesize the existing research on the application of GAs in SGs, with a focus on understanding the current state of the field, identifying common applications, challenges, and potential future directions. The review includes studies published in English that focus on the use of GAs within SGs. The search encompassed articles from academic journals and conference proceedings without restrictions on publication dates. Exclusion criteria included studies that did not specifically address the integration of GAs in SGs. A systematic search was conducted in databases such as ACM Digital Library, Web of Science, Scopus and Inspec in July 2024. The search terms used included "genetic algorithm," "evolutionary algorithm," "computational algorithm," and "serious games." Unpublished data and articles were not considered. Data were charted using a PRISMA flowchart developed by the author VV. Key categories for data extraction included study objectives, methods, outcomes, type of study and GA used and the specific applications of GAs in SGs. Data charting was conducted independently by two reviewers, with disagreements resolved through discussion and consensus. The search identified 154 studies, of which 23 met the inclusion criteria. The included studies highlight the diverse applications of GAs in SGs, ranging from optimizing game scenarios to personalizing learning experiences. Challenges identified include the computational complexity of GAs and difficulties in their integration into existing game frameworks. The findings of this review suggest that while the use of GAs in SGs is a promising area of research, it remains in its nascent stages. Future research should focus on addressing the technical challenges of integrating GAs into SGs and exploring their application across a wider range of game genres and educational contexts. Limitations of the review include the potential for publication bias and the exclusion of non-English language studies.

Preprint ARTICLE | doi:10.20944/preprints201806.0317.v1

Performance of Resource Allocation in Device-to-Device Communication Systems Based on Evolutionally Optimization Algorithms

Hsu-Tan Tan, Bor-An Chen, Yung-Fa Huang

Subject: Engineering, Electrical And Electronic Engineering Keywords: device-to-device; LTE systems; resource allocation; particle swarm optimization algorithm; genetic algorithm; system capacity

Online: 20 June 2018 (09:31:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0543.v1

Solving the Transport Infrastructure Investment Projects Selection and Scheduling as a Multiple Knapsack Problem Using Genetic Algorithms

Karel Ječmen, Denisa Mocková, Dušan Teichmann

Subject: Computer Science And Mathematics, Discrete Mathematics And Combinatorics Keywords: genetic algorithms; multiple knapsack problem; scheduling; transport infrastructure investment projects; transport infrastructure development

Online: 6 September 2024 (12:39:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1820.v1

A Genetic Algorithms Enhanced Sensor Marks Selection Algorithm For Advanced Photolithography Process

Aris Magklaras, Alefragkis Panagiotis, Christos Gogos, Christos Valouxis, Alexios Birbas

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Photolithography; Optimal Design of Experiments; Optimal Experimental Design; D-optimal; G-Optimal; A-Optimal; Control Algorithm; Optimization; Genetic Algorithms; Compound Criteria

Online: 26 June 2023 (14:02:17 CEST)

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In photolithography process, nanometer level precise, wavefront aberration models enable the machine to be able to meet the overlay (OVL) drift and critical dimension (CD) specifications. Software control algorithms take as input these models and correct any expected wavefront imperfections before reaching the wafer. In such way a near optimal image is exposed on the wafer surface. Optimizing the parameters of these models though, involves several time costly sensor measurements which reduce the throughput performance, in terms of exposed wafers per hour, of the machine. In that case, photolithography machines come across the trade-off between throughput and quality. Therefore one of the most common Optimal Experimental Design (OED) problems in photolithography machines (and not only) is how to choose the minimum amount of sensor measurements that will provide the maximum amount of information. Additionally, each sensor measurement corresponds to a point on the wafer surface and therefore we must measure uniformly around the wafer surface as well. In order to solve this problem, we propose a Sensor Marks Selection Algorithm which exploits Genetic Algorithms. The proposed solution first selects a pool of points that qualify as candidates to be selected in order to meet the uniformity constraint. Then, the point that provides the maximum amount of information, quantified by the Fisher based criteria of G, D and A-Optimality, is selected and added to the measurement scheme. This process though is considered "greedy", and for this reason Genetic Algorithms (GA) are exploited to further improve the solution. By repeating in parallel the "greedy" part several times we get an initial population that will be the input to our GA. This meta-heuristic approach outperforms the "greedy" approach significantly. The proposed solution is applied in a real life semiconductors industry use case and achieves interesting industry and academical results as well.

Preprint ARTICLE | doi:10.20944/preprints202307.1870.v1

Optimization of water-jet pump based on the coupling of multi-parameter and multi-objective genetic algorithms

Yun Long, Tian Chenbiao, Qiang Zhuang, Zhu Rongsheng, Junlian Yin, Dezhong Wang

Subject: Engineering, Marine Engineering Keywords: multi-parameter 1; multi-objective 2; genetic algorithms 3; water jet pump 4; impellers 5; optimal design 6.

Online: 27 July 2023 (08:36:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0167.v1

Use of 3-Way Voting of Machine Learning Algorithms Improves Prediction Performance of the Efficacy of Antisense-Mediated Exon Skipping and Reduces the Computational Burden

Alex Zhu, Shuntaro Chiba, Yuki Shimizu, Katsuhiko Kunitake, Yasushi Okuno, Yoshitsugu Aoki, Toshifumi Yokota

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: antisense oligonucleotides; exon skipping; machine learning; ensemble learning; personalized medicine; n-of-1 therapy; splice switching; genetic disease; splicing; RNA

Online: 9 March 2023 (04:43:55 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202401.1175.v1

The Importance of Offering Exome or Genome Sequencing in Adult Neuromuscular Clinics

Laynie Dratch, Tanya M Bardakjian, Kelsey Johnson, Nareen Babaian, Pedro Gonzalez-Alegre, Lauren Elman, Colin Quinn, Michael H Guo, Steven S Scherer, Defne A Amado

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Neurogenetics; genetic testing; genetic counseling; neuromuscular

Online: 16 January 2024 (06:25:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0481.v1

IRAPs in Combination with Highly Informative ISSRs Confer Effective Potentials for Genetic Diversity and Fidelity Assessment in Rhododendron

Sulin Wen, Hong Zhao, Manying Zhang, Guang Qiao, Xiaohui Shen

Subject: Biology And Life Sciences, Plant Sciences Keywords: genetic fidelity; genetic diversity; IRAP; ISSR; Rhododendron

Online: 28 March 2023 (09:56:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1531.v1

Pregnancy Planning and Genetic Testing: Exploring Advantages, and Challenges

Ulf Kristoffersson, Maria Johansson-Soller

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Pregnancy planning and genetic testing; preconception genetic testing; genetic disorders; reproductive healthcare; genetic counselling; ethical and societal considerations

Online: 18 July 2024 (16:48:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1357.v1

Revisiting Classical Controllers Design and Tuning with Genetic Programming

Carlos A. García, Manel Velasco, Cecilio Angulo, Pau Marti, Antonio Camacho

Subject: Engineering, Control And Systems Engineering Keywords: genetic algorithm; genetic programming; control design; control tuning

Online: 22 November 2023 (07:49:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1532.v1

Adapt the Parameters of RBF Networks Using Grammatical Evolution

Ioannis G. Tsoulos, Alexandros Tzallas, Evangelos Karvounis

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Neural networks; Genetic algorithms; Genetic programming; Grammatical evolution

Online: 22 September 2023 (08:37:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0583.v1

A Systematic Review on Extreme Phenotype Strategies to Search for Rare Variants in Genetic Studies of Complex Disorders

Sana Amanat, Teresa Requena, Jose Antonio Lopez-Escamez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic association studies; extreme phenotype; genetic epidemiology; tinnitus

Online: 24 July 2020 (13:43:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1729.v1

Assessment of Diversity and Genetic Variability of Guava (Psidium guajava) by Means of Microsatellite Markers in Montería, Córdoba-Colombia

Enrique Pardo-Perez, Elizabeth Ramos-Rivero, Luis Causil-Vargas

Subject: Biology And Life Sciences, Life Sciences Keywords: genetic diversity; genetic variability; microsatellites; allele frequencies; population structure

Online: 28 November 2023 (08:08:48 CET)

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Working Paper ARTICLE

Operationalising Forensic Genetic Genealogy in an Australian Context

Nathan Scudder, Runa Daniel, Jennifer Raymond, Alison Sears

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: forensic genetic genealogy; investigative genetic genealogy; DNA; forensic DNA

Online: 1 August 2020 (16:29:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0010.v1

Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso

Nouhoun Traoré, Mahamadi Kientega, Hamidou Maïga, Karim Nebié, Issaka Zida, Roberto Galizi, Emmanuel Kiendrebeogo, Bazoumana BD Sow, Adrien M. G. Belem, Remy A. Dabiré, Abdoulaye Diabaté

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: genetic diversity; genetic structure; microsatellite markers; Bactrocera dorsalis; Burkina Faso

Online: 1 March 2024 (07:57:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1083.v1

Prevalence of Genetic Variants and Deep Phenotyping of Patients with Thoracic Aortic Aneurysm and Dissection: A Cross-Sectional Single Centre Cohort Study

Adrian Mahlmann, Nesma Elzanaty, Mai Saleh, Marc Irqsusi, Ardawan Rastan, Jennifer Lynne Leip, Christian-Alexander Behrendt, Tamer Ghazy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: thoracic aortic disease; phenotype; genetic mutation; genetic variant; aneurysm; dissection

Online: 14 December 2023 (12:14:50 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202011.0387.v1

Genetic Music: When Genes Code for Melodies Instead of Proteins

Marga Consortium, Blanca A. Gutierrez, Iván Aitor Lucas del-Amo, Beatriz Alejos Bermudez, Cristina Gonzalez Moran, Veronica Noval Gutierrez, Borja Sanchez

Subject: Social Sciences, Anthropology Keywords: genetic music; genetic code; music composition; steam disciplines; notch1 gene

Online: 13 November 2020 (15:34:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0047.v1

Genetic Structure and Eco-Geographical Differentiation of Wild Sheep Fescue (Festuca ovina L.) in Xinjiang, Northwest China

Chenglin Zhang, Jianbo Zhang, Yan Fan, Ming Sun, Wendan Wu, Wenda Zhao, Xiaopeng Yang, Linkai Huang, Yan Peng, Xiao Ma, Xinquan Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Festuca ovina L.; AFLP, genetic diversity; genetic barriers; environmental factors

Online: 18 July 2017 (10:05:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0711.v1

Unlocking glioblastoma vulnerabilities with CRISPR-based genetic screening

Yitong Fang, Xing Li, Ruilin Tian

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: glioblastoma; CRISPR-based genetic screening; therapy resistance; genetic determinants; therapeutic targets

Online: 10 April 2024 (08:14:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0738.v1

Utility of Whole-Exome Sequencing in Pediatric and Medical Diagnosis

Mohd Fareed, Varun Sharma, Hemender Singh

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Next generation sequencing; Genetic disorders; Genomic medicine; Genetic counseling; Rare diseases

Online: 29 December 2020 (16:47:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0144.v1

Genetic Environments of Plasmid-Mediated bla_CTXM-15beta-lactamase gene in Enterobacteriaceae from Africa

Babafela Awosile, Michael Agbaje

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Antimicrobial resistance; blaCTX-M-15; genetic environment; mobile genetic elements; Africa

Online: 7 December 2020 (12:49:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1346.v1

Bibliometric Analysis on Genetic Factors of Osteoarthritis Pathogenesis: Characteristics and Trends from 2014 to 2023

Yangguang Lu, Feitian Ni, Yiran Bu, Jialing Lou, Bohuai Yu, Hongzhi Zhang, Haoyang Li, Yige Zhang, Hantao Hu, Di Lu

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: bibliometrics; genetic factors; Osteoarthritis

Online: 18 December 2023 (13:42:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1185.v1

Genetic regulation of human isomiR biogenesis

Guanglong Jiang, Jill L. Reiter, Chuanpeng Dong, Yue Wang, Fang Fang, Zhaoyang Jiang, Yunlong Liu

Subject: Computer Science And Mathematics, Mathematical And Computational Biology Keywords: microRNA; isomiR; genetic association

Online: 18 July 2023 (07:52:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0710.v1

Genetic Algorithm Based Feature Selection Technique for Optimal Intrusion Detection

Sydney Mambwe Kasongo

Subject: Engineering, Automotive Engineering Keywords: Intrusion Detection; Genetic Algorithm

Online: 29 June 2021 (13:30:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1705.v1

MixDeR: A SNP Mixture Deconvolution Workflow for Forensic Genetic Genealogy

Rebecca Mitchell, Michelle Peck, Erin Gorden, Rebecca Just

Subject: Biology And Life Sciences, Other Keywords: mixtures; SNPs; forensic genetic genealogy (FGG); investigative genetic genealogy (IGG); Kintelligence; software

Online: 24 July 2024 (14:45:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0276.v1

Genetic Variation of Traits in Natural Enemies Relevant for Biological Control: A Systematic Review

Kim B. Ferguson, Sophie R. Chattington, Wouter N. Plouvier, Bart A. Pannebakker

Subject: Biology And Life Sciences, Insect Science Keywords: genetic improvement; genetic variation; heritability; systematic review; biocontrol agent; life history traits

Online: 24 January 2020 (10:39:55 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.0328.v1

The Effect of Pathogenic Tumor Suppressor Gene Variants on COVID-19: A Report of Three Cases with Varied Severity and Outcomes

Rostislav K. Skitchenko, Yury A. Barbitoff, Mikhail A. Fedyakov, Anna Yu. Anisenkova, Sergei V. Mosenko, Svetlana V. Apalko, Andrey S. Glotov, Oleg S. Glotov, Sergey G. Shcherbak

Subject: Biology And Life Sciences, Other Keywords: COVID-19; SARS-CoV-2; oncology; genetic variants; NGS; severity; genetic associations; exome

Online: 6 December 2023 (08:52:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0099.v1

Genetic Parameters of Growth Traits and Quantitative Genetic Metrics for Selection and Conservation of Mecheri Sheep of Tamil Nadu

B. Balasundaram, A.K. Thiruvenkadan, N. Murali, J. Muralidharan, D. Cauveri, Sunday O. Peters

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Genetic parameters, (Co)variance components, Mecheri sheep, Animal models, Maternal genetic influence, Inbreeding

Online: 6 December 2022 (10:03:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0509.v1

Genetic Variation of Native Perilla Germplasms Collected from South Korea Using SSR Markers and Morphological Characteristics

Jun Seok Oh, Kyu Jin Sa, Hyeon Park, Do Yoon Hyun, Sookyeong Lee, Ju-Hee Rhee, Ju Kyong Lee

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Perilla crop; genetic resources; morphological traits; principal component analysis; SSR marker; genetic variation

Online: 22 July 2021 (08:04:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1730.v1

Genetic Diversity of Human Norovirus in Children Less Than 5 Years of Age With Acute Gastroenteritis in Rural Communities in the Gambia

Sheriffo Jagne, M. Jahangir Hossain, Martin Antoni, Abdul Karim Sesay, Muhammed Khalie Abdul, Nuredin I. Mohammed, Madikay Senghore, Alansana Darboe, Jarra Manneh, Abdoulie Kanteh, Dam Khan, Saikou Y Bah, Ndaw Sylvanus Peter, Osbourne Quaye, George Enyimah Armah

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Norovirus genetic diversity genogroups genotypes

Online: 24 January 2024 (10:15:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0706.v2

Dr Jekyll and Mr Hyde: From Two Branches of Immune Response to Three Types of Interferon Response

Brent Brown, Chinua Imarogbe, Ingo Fricke, Pascal Mensah

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Interferon; Innate; Adaptive; Genetic; Molecular

Online: 26 September 2023 (11:35:53 CEST)

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Interferons were the original prototype cytokine system discovered in 20th-century research. As the name implies, they were originally thought to be synthesised and secreted between cells. Thanks to technological advances, the processes involved in protein secretion can be explained comparatively more clearly at both the genetic and biochemical levels. The discovery of interferon (IFN) occurred when genetic research was still in its infancy. Franklin and Wilkins discovered the structure and function of deoxyribonucleic acid (DNA) at the same time as Crick and Watson; however, Isaacs and Lindemann, two scientists, described the first IFN in 1957. Mutations can be caused by inherent genetic protein synthesis and during infection as well as within IFN regulation pathways affecting cell proliferation. This remains central to host cell IFN synthesis and effects through IFN protein receptor subunits defined by 6 protein domains. Type II IFN is key to immune cell function secreted by a variety of immune cells, mainly natural killer (NK) as well as T cells. Single–stranded and/or double–stranded RNA/DNA viruses, as well as bacterial infections (e.g., Escherichia coli) and fungal infections (e.g., Aspergillus), also affect IFN regulation. Pathogenic proteins utilise intra/extracellular proteins that sense foreign antigens like Toll–like Receptors (TLRs), affected by mutations within the human cellular IFN transduction pathways. Since the discovery of the third IFN type in 2003, when immune cell phenotypes were further characterised, questions remain about the immunological mechanisms contributing to the regulation of the innate and adaptive host immune system. Alterations in the synthesis of type I/II/III host IFNs can differentially and beneficially alter homeostatic cellular pathways in pathological disease, with type I IFN being synthesised in cancer as well as by homeostatic cells. Therefore, considered here are the overall IFN molecular, cell regulatory mechanisms in the context of immune cell research developments.

Preprint CASE REPORT | doi:10.20944/preprints202306.0239.v1

Optimal Evaluation of Left Ventricular Hypertrophic Phenotype Using Parametric CMR Mapping and Genetic Testing

Andrés Felipe Barragán-Amado, Jaime A Parra, María C Manzur, Julian A Gelves-Meza, Claudia P Jaimes, María F Tamayo, Héctor M Medina, María Juliana Rodríguez-González

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiomyopathy; Genetic disorders; Cardiovascular Imagen

Online: 5 June 2023 (05:02:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0114.v1

Genetic Determinants of Atherogenic Indexes

Tomas Texis, Susana Rivera-Mancia, Eloisa Colin-Ramirez, Raul Cartas-Rosado, David Koepsell, Kenneth Rubio-Carrasco, Mauricio Rodriguez-Dorantes, Vanessa Gonzalez-Covarrubias

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Dyslipidemia; atherogenic indexes; genetic associations

Online: 7 April 2023 (05:24:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1960.v1

Directional Breeding Generates Distinct Genetic Diversity in Hybrid Turf Bermudagrass as Probed with SSR Markers

Desalegn D. Serba, Tilin Fang, Yanqi Wu

Subject: Biology And Life Sciences, Plant Sciences Keywords: C. dactylon; C. transvaalensis; interspecific hybrids; cluster analysis; genetic similarity; genetic diversity; directional breeding

Online: 29 May 2023 (08:55:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0021.v1

Protein 0^th-Order Structure: The Key for Creating Entirely New Gene/Protein

Kenji Ikehara

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein 0th-order structure; origin of gene; origin of protein; origin of genetic code; GNC primeval genetic code hypothesis; SNS primitive genetic code hypothesis

Online: 3 December 2019 (11:10:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0169.v1

The Supersymmetry Genetic Code Table and Quadruplet Symmetries of DNA Molecule Are the Unchangeable and Synchronized with the Codon Free Energy Mapping during Evolution

Marija Rosandic, Vladimir Paar

Subject: Biology And Life Sciences, Other Keywords: genetic code symmetry, mitochondrial genetic code, energy code, DNA quadruplet symmetry, classification of trinucleotides/codons

Online: 4 October 2023 (07:43:22 CEST)

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The Supersymmetry Genetic code (SSyGC) table is based on five physicochemical symmetries: 1) double mirror symmetry on the principle of the horizontal and vertical mirror symmetry axis between all bases (purines [A, G) and pyrimidines (U, C)], and 2) of bases in form of codons 3) direct – complement like codon/anticodon symmetry in the sixteen alternating boxes of the genetic code columns, 4) A+T rich and C+G rich alternate codons in the same row between both columns of the genetic code, 5) the same position between divided and undivided codon boxes in relation to horizontal mirror symmetry axes. The SSyGC table has a unique physicochemical purine – pyrimidine symmetry net which is as the core symmetry common for all, more than thirty different nuclear and mitochondrial genetic codes. This net is present in the SSyGC table of all RNA and DNA living species. None of these symmetries is present in the Standard Genetic Code (SGC) table which is constructed on the alphabetic horizontal and vertical U-C-A-G order of bases. Here we show that the free energy value of each codon incorporated as fundamentally mapping the “energy code” in the SSyGC table is compatible with mirror symmetry. On the other hand, in the SGC table the same free energy values of codons are dispersed and a mirror symmetry between them is not recognizable. At the same time the mirror symmetry of the SSyGC table and the DNA quadruplets together with our classification of codons/trinucleotides are perfectly imbedded in the mirror symmetry energy mapping of codons/trinucleotides and point out in favor of maintaining the integrity of the genetic code and DNA genome. We also argue that physicochemical symmetries of the SSyGC table in the manner of the purine – pyrimidine symmetry net, the quadruplet symmetry of DNA molecule and the free energy of codons have remined unchanged during all of evolution. The unchangeable and universal symmetry properties of the genetic code, DNA molecule and energy code are decreasing disorder between codons/trinucleotides and shed a new light on evolution. Diversity in all living species on Earth is broad, but the symmetries of the Supersymmetry Genetic Code as the code of life and the DNA quadruplets related to the” energy code” are unique, unchangeable and have the power of natural laws.

Preprint ARTICLE | doi:10.20944/preprints202212.0234.v1

History of Advances in Genetic Engineering of Viruses Prior to COVID-19 Pandemic

Mikhail Teppone

Subject: Biology And Life Sciences, Virology Keywords: reassortant virus; recombinant virus; chimeric virus; genetic engineering; reverse genetic; SARS-CoV-2; COVID-19

Online: 13 December 2022 (08:47:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202407.0205.v1

Genetic Characterization of Some Accessions of Barley in Algeria with Microsatellites (SSR) Markers

Warda Taibi, Fatima Henkrar, Sripada Mahabala Udupa, Suheil bechir semir Gaouar

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Genetic diversity; SSR markers; barley; Algeria

Online: 2 July 2024 (14:49:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0870.v1

Selection of Improved Banana Diploid Resistant to Fusarium oxysporum f. sp. cubense Races 1 and Subtropical 4

Welly Sacramento Santana, Anelita de Jesus Rocha, Wesley Barreto da Silva, Vanusia B. Oliveira Amorim, Andresa Priscila de Souza Ramos, Fernando Haddad, Edson Perito Amorim

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Musa spp; genetic resistance; Fusarium wilt

Online: 15 April 2024 (04:25:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0274.v1

Constructing the Bounds for Neural Network Training Using Grammatical Evolution

Ioannis G. Tsoulos, Alexandros Tzallas, Evangelos Karvounis

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Neural networks; Genetic algorithms; Grammatical Evolution

Online: 5 October 2023 (10:59:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1482.v1

Comparative Proteomic Analysis of Toxoplasma gondii RH Wild-Type and Four SRS29B (SAG1) Knock-Out Clones Reveals Significant Differences between Individual Strains

Kai Pascal Alexander Hänggeli, Andrew Hemphill, Norbert Müller, Manfred Heller, Uldry Anne-Christine, Sophie Braga-Lagache, Joachim Müller, Ghalia Boubaker

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic manipulation; pleiotropic effects; systems biology

Online: 22 May 2023 (09:03:52 CEST)

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In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a suitable tool to identify the role of specific genes. The general consensus implies that only the gene of interest is affected by the knock-out. Is this really the case? In a previous study, we have generated knock-out (KO) clones of TgRH88_077450 (SRS29B; SAG1) which differed in the numbers of integrated dihydrofolate-reductase-thymidylate-synthase (MDHFR-TS) drug-selectable marker. Clones 18 and 33 had a single insertion of MDHFR-TS within SRS29B. Clone 6 was disrupted by the insertion of a short unrelated DNA-sequence, but the marker was integrated elsewhere. In clone 30, the marker was inserted into SRS29B and several other MDHFR-TS copies were found in the genome. KO and wild-type (WT) tachyzoites had similar shape, dimensions and vitality. This prompted us to investigate the impact of the genetic engineering as such on the overall proteome patterns of the four clones as compared to the respective WT. Comparative shotgun proteomics of the five strains was performed. Overall, 3236 proteins were identified. Principal component analysis of the proteomes revealed five distinct clusters corresponding to the five strains by both iTop3 and iLFQ algorithms. Detailed analysis of the differentially expressed proteins revealed that the target of the KO, srs29B, was lacking in all KO clones. Besides this protein, twenty other proteins were differentially expressed between KO clones and WT or between different KO clones. The protein exhibiting the highest variation between the five strains was srs36D encoded by TgRH_016110. The deregulated expression of SRS36D was further validated by quantitative PCR. Moreover, the transcript levels of three other selected SRS genes, namely SRS36B, SRS46, and SRS57 exhibited significant differences between individual strains. These results indicate that knocking out a given gene may affect the expression of other genes. Therefore, care must be taken when specific phenotypes are regarded as a direct consequence of the KO of a given gene.

Preprint ARTICLE | doi:10.20944/preprints202301.0075.v1

Deep Network Optimization Using a Genetic Algorithm for Recognizing Hand Gestures via EMG Signals

Kasra Sehat, Seyed Mohammadreza Shokouhyan, Nada K. Abdallah, Kinda Khalaf

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: EMG; optimization; genetic algorithm; deep learning

Online: 4 January 2023 (09:21:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0414.v1

Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions

Deiviane Calegar, Beatriz Nunes, Kerla Monteiro, Polyanna Bacelar, Brenda Evangelista, Mayron Moraes, Jurecir Silva, Jéssica Santos, Márcio Bóia, Lauren Jaeger, Filipe Anibal Carvalho-Costa

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Giardia duodenalis; Assemblages; Epidemiology; Genetic diversity

Online: 27 January 2022 (11:18:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0533.v1

Unlocking the Complete Chloroplast Genome of a Native Tree Species from the Amazon Basin, Capirona (Calycophyllum spruceanum Benth., Rubiaceae), and Its Comparative Analysis with Other Ixoroideae Species

Carla L. Saldaña, Pedro Rodriguez-Grados, Julio C. Chávez-Galarza, Shefferson Feijoo, Juan Carlos Guerrero Abad, Héctor V. Vásquez, Jorge L. Maicelo, Jorge H. Jhoncon, Carlos I. Arbizu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: chloroplast; genetic resources; genomics capirona; phylogenomics

Online: 29 November 2021 (12:32:24 CET)

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Working Paper ARTICLE

Evaluation of the Gene Flow From East to West among Various Populations of Rajasthan, India

R.K. Kumawat, Pankaj Shrivastava, Shivani Dixit, Divya Shrivastava, G.K. Mathur, Gyaneshwer Chaubey

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Genetic affinity; STR; Rajasthan; Heterozygosity; Polymorphic

Online: 21 June 2020 (14:12:03 CEST)

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Working Paper REVIEW

Physicochemical Foundations of Life that Direct Evolution. Why Chance and Natural Selection cannot Explain Evolution

Didier Auboeuf

Subject: Biology And Life Sciences, Biophysics Keywords: evolution; genetic code; RNA; protein; physicochemistry

Online: 28 November 2019 (09:38:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0349.v1

Genetic Diversity of Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae) Colonizing Sweet Potato and Cassava in South Sudan

Beatrice Clarence Misaka, Everlyne N. Wosula, Philip W. Marchelo-d'Ragga, Trine Hvoslef-Eide, James Peter Legg

Subject: Biology And Life Sciences, Forestry Keywords: Bemisia tabaci; genetic diversity; distribution; haplotype

Online: 28 November 2019 (03:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0201.v1

The Critical Needs and Challenges for Genetic Architecture Studies in Africa

Alicia R. Martin, Solomon Teferra, Marlo Möller, Eileen G. Hoal, Mark J. Daly

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic architecture; Africa; GWAS; health disparities

Online: 13 June 2018 (11:17:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1951.v1

Groups of Symmetries of the Two Classes of Synthetases in the Four-Dimensional Hypercubes of the Extended Code Type II

Marco V. José, Eberto R. Morgado, Juan R. Bobadilla

Subject: Biology And Life Sciences, Life Sciences Keywords: Aminoacyl-tRNA synthetases; Standard Genetic Code; Symmetry groups; Origin and evolution of the genetic code; Group Theory

Online: 29 August 2023 (08:34:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1280.v1

Enhancing Drought and Arsenic Resistance in Oryza sativa by Hyperexpression of Aquaporin Genes

Prisha Bhat

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Arsenic contamination; Rice arsenic; genetic augmentation; bioremediation

Online: 20 May 2024 (12:53:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0592.v1

Progress and Application of Genomic Selection in Sheep and Goat

Linyun Zhang, Yixin Duan, Naiyi Xu, Yongju Zhao

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Goat; Sheep; Genomic Selection; Genetic Evaluation; Accuracy

Online: 9 May 2024 (11:57:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1144.v1

Linking Wetland Ecosystem Services to Fish Genetic Resources with Special Reference to Hilsa Shad (Tenualosa ilisha): A Novel Study from Northeastern Bangladesh

Atiqur Rahman Sunny, Md. Arifur Rahman, Md. Nazmul Hasan, Jeba Faizah Rahman, Sharif Ahmed Sazzad, Md. Faruque Miah, Md. Ashrafuzzaman, Shamsul Haque Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Wetland; Ecosystem services; Genetic diversity; Hilsa; Bangladesh

Online: 20 February 2024 (12:44:47 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1693.v2

Creutzfeldt -Jakob Disease Associated with E200K Mutation and SARS-Cov2 Infection, Pure Coincidence or Neurodegenerative Acceleration?

Elisa Colaizzo, Luca Prosperini, Antonio Petrucci, Alessia Perna

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: genetic CJD; mutation E200K; COVID-19; prion

Online: 27 December 2023 (05:21:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.2104.v1

Optimization of Dual-Design Operation Ventilation System Network Based on Improved Genetic Algorithm

Yanbo Feng, Han Zhu, Xiwen Feng, Qianru Chen, Xiangyu Sun, Zhengrong Li

Subject: Engineering, Architecture, Building And Construction Keywords: ventilation system networks; design optimization; genetic algorithm

Online: 1 November 2023 (03:55:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0827.v1

AI-Based Procedure for the Assessment of Voice Characteristics in Genetic Syndromes

Federico Calà, Lorenzo Frassineti, Elisabetta Sforza, Roberta Onesimo, Lucia D’Alatri, Claudia Manfredi, Antonio Lanata, Giuseppe Zampino

Subject: Engineering, Bioengineering Keywords: Genetic syndrome; Acoustical analysis; Artificial Intelligence; Classification

Online: 12 October 2023 (12:03:32 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202309.1918.v1

Isoniazid-Resistant Tuberculosis—A Series of Clinical Cases

Teodora Butnaru, Florin Dumitru Mihaltan, Ancuta Alina Constantin

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: multidrug-resistant tuberculosis; genetic mutations; clinical cases.

Online: 28 September 2023 (08:02:58 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202309.1060.v1

Rare and Complex Cardiac Anomalies Associated with 22q11.2 Deletion: An Ultrasonographic Visual Trip from Diagnosis until Delivery

Radu Vlădăreanu, Călina Maier, Raluca Tocariu, Marcela Șerban, Elvira Brătilă

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: interrupted aortic arch; 22q11.2DS; ultrasound; genetic tests

Online: 18 September 2023 (05:41:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0114.v1

Design and Multi-Objective Optimization of a Photovoltaic System by a Genetic Algorithm

Khadidjatou Thiaw, Amadou Diao, Amy Sadio, Senghane Mboji

Subject: Physical Sciences, Applied Physics Keywords: photovoltaic system; LPSP; TLCC; optimization; genetic algorithm

Online: 4 September 2023 (03:50:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0697.v1

Selection of Short-Day Strawberry Genotypes through Multivariate Analysis

Thiago Rutz, Juliano Tadeu Vilela de Resende, Keny Henrique Mariguele, Ricardo Antônio Zeist, Andre Luiz Biscaia Ribeiro da Silva

Subject: Biology And Life Sciences, Horticulture Keywords: Fragaria × ananassa; genetic parameters; selection index; clusterin

Online: 11 July 2023 (08:40:08 CEST)

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Strawberry is produced in tropical regions using imported cultivars adapted to temperate and subtropical climates. These cultivars, under tropical conditions, produce below their genetic potential. Through multivariate analyses, the objective was to evaluate and select short-day strawberry genotypes based on intraspecific crosses, product characteristics, and fruit quality. The genotypes were obtained from the cross between 'Camino Real' (female parent) and the first-generation genotypes RVCA16, RVCS44, RVFS06, RVFS07, and RVDA11 (male parent), obtained in previous selections. The experimental design consisted of augmented blocks with standard controls, consisting of first-generation genotypes and commercial cultivars. The fruits were harvested and evaluated for productivity and post-harvest characteristics: Total Fruit Mass (MTF); Total Number of Fruits (TFN); Average Fruit Mass (AFM); Commercial Fruit Mass (CFM); Fruit Commercial Number (CFN); Average Commercial Mass of Fruits (ACFM); Total Soluble Solids (TSS); Firmness (F); Brightness (L); Hue Angle (°Hue); Chroma (C). The selection index of Mulamba and Mock (1978) was used with an intensity of 3% to obtain superior genotypes and submitted to multivariate analysis for comparative purposes. Of the 1500 genotypes evaluated, it was possible to select 44 genotypes with characteristics superior to the 13 controls. The RVDA11CR59 genotype showed better values for the attributes of interest, but the RVCS44CR population, from the cross between 'Camino Real' × RVCS44 ('Camarosa' × 'Sweet Charlie'), obtained the highest number (16) of individuals among those selected. Significant traits had high heritability but were not necessarily reflected in high selection gain. Coefficients of genetic variation were high, indicating sufficient genetic variability to select genotypes for these traits. When multivariate analyses were used, it was possible to group the selected genotypes into the same cluster according to the similarity and balance in the responses to the evaluated variables, demonstrating that these analyses help other parameters choose superior genotypes. The multivariate analysis allowed the selection of more balanced genotypes for production and post-harvest traits for tropical climates.

Preprint ARTICLE | doi:10.20944/preprints202306.0020.v1

Genetic Drift and Alphapapillomavirus Evolution

Robert D. Burk, Lisa Mirabello, Robert DeSalle

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: molecular evolution; genetic drift; human papillomavirus (HPV)

Online: 1 June 2023 (03:52:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1634.v1

Genotypic and Sanitary Characterization of Minority Grapevine Varieties Prospected in Andalusia, Spain

Inmaculada Rodríguez-Torres, Ana Martín Carrillo, María del Pilar Ramírez, Francisco Jesus Gómez Gálvez, Leonardo Velasco Arjona, Carlos Padilla, Enrico Cretazzo

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: genetic resources; molecular markers; local cultivar; certification

Online: 23 May 2023 (09:55:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1454.v1

Relevance of Genetic Identification and Kinship Analysis in Human and Natural Catastrophes – A Review

Alejandra Real-Picado, Luis Diaz, Cláudia Gomes

Subject: Medicine And Pharmacology, Other Keywords: Catastrophes; Genetic identification; Kinship analysis; DNA degradation

Online: 22 May 2023 (03:01:25 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0087.v1

Recent Population Dynamics of Japanese Encephalitis Virus

Jinpeng Xu, Abdul Wahaab, Sawar Khan, Mohsin Nawaz, Muhammad Naveed Anwar, Ke Liu, Jianchao Wei, Muddassar Hameed, Zhiyong Ma

Subject: Biology And Life Sciences, Virology Keywords: Japanese encephalitis virus; Population dynamic; Genetic diversity

Online: 2 May 2023 (11:02:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0505.v1

Tomato Defence Suppression is a Common Trait in Tetranychus urticae Collected from Field-Grown Tomatoes

Jéssica Teodoro-Paulo, Carlos Fernandes, Lin Dong, Sara Magalhães, Alison B. Duncan, Juan M. Alba, Merijn R. Kant

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: phylogeny; salivary effectors; effector 84; genetic diversity

Online: 28 February 2023 (04:44:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0305.v1

National and Ethnic Mutation Frequency Databases: Cross Comparison and Future Direction

Shumaila Khan, Mehmood Alam, Shahnaz Khan, Wahab Khan, Ihsan Rabbi, Iqbal Qasim

Subject: Computer Science And Mathematics, Information Systems Keywords: genetic databases; mutation disorders; ethnic specific databases

Online: 17 February 2023 (07:59:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0197.v1

Potential Genetic Biomarkers of Suicide Risk in the Mexican Population: A Systematic Literature Review

Juan Angel Garcia-Quiñones, Celia Nohemi Sanchez-Dominguez, María Fernanda Serna-Rodríguez, Ivan Alberto Marino-Martinez, Ana María Rivas-Estilla, Antonio Alí Pérez-Maya

Subject: Social Sciences, Behavior Sciences Keywords: Biomarkers; Genetic; Suicidal behavior; Suicide; Mexican; Genomic.

Online: 11 January 2023 (10:34:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0430.v1

Optimization of Water Distribution Networks Using Genetic Algorithm based SOP–WDN Program

Uchit Sangroula, Kuk-Heon Han, Kang-Min Koo, Kapil Gnawali, Kyung-Taek Yum

Subject: Engineering, Civil Engineering Keywords: Water distribution networks; Optimization; Genetic Algorithm; EPANET

Online: 28 January 2022 (08:53:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0400.v1

The rs599839 A>G Variant Disentangles Cardiovascular Risk and Hepatocellular Carcinoma in NAFLD Patients

Marica Meroni, Miriam Longo, Erika Paolini, Anna Alisi, Luca Miele, Emilia Rita De Caro, Giuseppina Pisano, Marco Maggioni, Giorgio Soardo, Luca Vittorio Valenti, Anna Ludovica Fracanzani, Paola Dongiovanni

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Lipid metabolism; NAFLD; genetic variants; PSRC1; HCC

Online: 15 March 2021 (16:30:15 CET)

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Working Paper CONCEPT PAPER

The Physics–Biology Continuum Refutes Darwinism: Evolution is Directed by the Homeostasis-Dependent Bidirectional Relation between Genome and Phenotype

Didier Auboeuf

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: evolution; darwinism; genetic code; RNA; homoestasis; physics

Online: 6 January 2021 (15:06:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0003.v2

Non-Homologous end Joining Factors XLF, PAXX and DNA-PKcs Maintain the Neural Stem and Progenitor Cell Population

Raquel Gago-Fuentes, Valentyn Oksenych

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA repair; NHEJ; synthetic lethality; genetic interaction

Online: 15 December 2020 (10:41:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0653.v1

DetR DB: A Database of Ionizing Radiation Resistance Determinants

Alina Ryabova, Olga Kozlova, Azat Kadirov, Oleg Gusev, Elena Shagimardanova

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ionizing radiation; radiation resistance; genetic mechanisms; microorganisms

Online: 26 September 2020 (17:24:56 CEST)

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Working Paper HYPOTHESIS

Human Genetic Diversity Possibly Determines Human's Compliance to COVID-19

Yiqiang Zhao, Yunchun Gu, Yongji Liu, Sa Li, Yuzhan Wang, Lina Bu, Qi Liu, Hongyi Lv, Fang Wan, Lida Wu, Zemin Ning

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; severe symptoms; inactivation; genetic diversity

Online: 16 April 2020 (09:15:49 CEST)

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Working Paper ARTICLE

Assessment of Genetic Diversity of Dioscorea praehensilis (Berth.) Collected from Central Region, Ghana Using Simple Sequence Repeat (SSR) Markers

Adeyinka S. Adewumi, Kingsley J. Taah, Paul A. Asare, Michael O. Adu, Paterne A. Agre

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: genetic diversity; Dioscorea praehensilis; SSR markers; Ghana

Online: 8 March 2020 (14:55:19 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201912.0176.v1

A Framework for Maximising the Capture of Genetic Diversity in Sampling for ex situ Conservation

Linda Neaves

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: conservation; genetic diversity; decision-making; ex situ

Online: 12 December 2019 (12:43:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0046.v1

Stimulation of Replication Template-Switching by DNA-Protein Crosslinks

Laura T. Laranjo, Julie A. Klaric, Susan T. Lovett

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA replication, DNA repair, genetic recombination, mutagenesis

Online: 2 November 2018 (10:19:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0089.v1

The Importance of a Multidisciplinary Approach in the Management of a Patient with Type I Gaucher Disease

Miguel-Ángel Torralba-Cabeza, Susana Olivera-González, José-Luis Sierra-Monzón

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: multidisciplinary; Gaucher; genotype/phenotype correlation; genetic counselling

Online: 5 July 2018 (08:51:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0329.v1

Ethical, Legal and Social Implications of Susceptibility Genetic Testing for Late-Onset Neurodegenerative Diseases

Amaranta Manrique de Lara, Elisa Núñez-Acosta, Garbiñe Saruwatari-Zavala, Liliana Soto-Gómez, Miguel E. Rentería

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; Parkinson’s disease; Genetic testing; bioethics

Online: 21 June 2018 (04:38:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0191.v1

Recent Developments in Using Drosophila as a Model for Human Genetic Disease

Christine Oriel, Paul Lasko

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: rare disease; functional genomics; genetic variant validation

Online: 12 June 2018 (12:36:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0215.v1

Estimation of Genetic Parameters and Prediction of Genotypic Values in Common Beans Using Mixed Models

Jessica Delfini, Vania Moda Cirino, Claudete de Fátima Ruas, Paulo Mauricio Ruas, José dos Santos Neto, Leandro Simões Azeredo Gonçalves

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Phaseolus vulgaris L.; REML/BLUP; genetic diversity

Online: 26 March 2018 (10:35:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201707.0005.v1

Improved Forms for Controlling the Acrobot with Motors of Atypical Size Using Artificial Intelligence Techniques

Gonzalo Mier, Javier de Lope

Subject: Engineering, Control And Systems Engineering Keywords: Acrobot; Artificial Intelligence; SARSA; PWM; Genetic Algorithm

Online: 4 July 2017 (16:12:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2452.v1

Heterozygous Smad4 Knock out Effect on Pancreatic and Body Weight Variation in F1 Population Using Mutant and Wild Type Collaborative Cross Mice

Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Aysar Nashef, Imad Abu-Elnaaj, Fuad A. Iraqi

Subject: Biology And Life Sciences, Other Keywords: Smad4; pancreatic weight; genetic background; sex differences; Collaborative Cross; F1 mice; genetic modifiers; tumor suppressor gene

Online: 30 July 2024 (10:53:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2221.v1

Human-Activity-Mediated Gene Flows Are Involved in the Establishment of Magnaporthe oryzae Population Structures: A Population Genomic Analysis

Guohua Duan, Yuchan Liu, Cheng Zheng, Kaihui Yu, Jiahui Xie, Baohua Wang, Huakun Zheng, Wei Tang, Jiandong Bao, Zonghua Wang, Meilian Chen

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Magnaporthe oryzae; population structure; genetic diversity; gene flow

Online: 30 August 2024 (08:36:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0719.v1

Exploring the Rise in Precocious Puberty: Interplay of Genetic and Environmental Factors

Jhancy Malay, Biji Thomas George, Rajani Dube, Subhranshu Sekhar Kar, Imran Rashid Rangraze

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: precocious puberty; genetic factors; endocrinal factors; environmental factors

Online: 12 August 2024 (03:55:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202408.0682.v1

Genotype-Phenotype Correlations in Inherited Cardiomyopathies, Their Role in Clinical Decision-Making and Implications in Personalized Cardiac Medicine in Multi-omics as Well as Disease Modelling Eras

Yaqob Samir Taleb, Paras Memon, Aftab Ahmed Jalbani, Nouf AlMutairi, Sarah Al Mukhaylid, Nawaf Alanazi, Abdulkareem Al-Garni, Muneera Altaweel, Muhammad Aamir Khan, Muhammad Farooq Sabar, Zafar Iqbal

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cardiomyopathy; Multi-omics techniques; personalized medicine; genetic testing

Online: 9 August 2024 (12:13:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2564.v1

The Genetic Analysis and Clinical Therapy in Lung Cancer: Current Advances and Future Directions

Angela Rina, Debora Maffeo, Francesca Minnai, Martina Esposito, Maria Palmieri, Viola Bianca Serio, Diletta Rosati, Francesca Mari, Elisa Frullanti, Francesca Colombo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung cancer; genetic discoveries; target therapy; personalized treatments

Online: 31 July 2024 (14:29:41 CEST)

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