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Preprint ARTICLE | doi:10.20944/preprints202310.1331.v1

Research-Based Design of an Inclusive Park: Thammasat Water Sport Center, Pathum Thani, Thailand

Pattamon Selanon, Federico Puggioni, Supanut Dejnirattisai, Autchariya Rutchamart

Subject: Arts And Humanities, Architecture Keywords: inclusive park; disabilities; research-based design; research through designing

Online: 23 October 2023 (05:13:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202003.0020.v1

Situation Awareness–Oriented Patient Monitoring with Visual Patient Technology: A Qualitative Review of the Primary Research

David W. Tscholl, Julian Rössler, Sadiq Said, Alexander Kaserer, Donat R. Spahn, Christoph B. Noethiger

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: visual patient; patient monitoring; avatar-based technology; situation awareness; user-centered design

Online: 2 March 2020 (00:56:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0550.v1

Emerging Children Roles in Child-Computing Interaction Research: A Systematic Literature Review

Oluwadara Abimbade, Ibrahim Adisa

Subject: Social Sciences, Other Keywords: Participatory Design, Co-operative Inquiry, Design partners, Co-design

Online: 7 August 2023 (12:10:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0032.v1

Artificial Intelligence Technologies for COVID-19 De Novo Drug Design

Giuseppe Floresta, Chiara Zagni, Davide Gentile, Vincenzo Patamia, Antonio Rescifina

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: artificial intelligence; machine learning; drug design; covid-19; structure-based drug design; ligand-based drug design

Online: 2 March 2022 (03:00:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0558.v1

Investigating the Gap between Research and Practice in Additive Manufacturing

Jennifer Bracken, Zachary Bentley, James Meye, Erik Miller, Jablokow Kathryn W., Simpson Timothy, Meisel Nicholas

Subject: Physical Sciences, Acoustics Keywords: Additive Manufacturing; Design

Online: 27 January 2021 (12:31:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1164.v1

The Impact of C-3 Side Chain Modifications on Kynurenic Acid: A Behavioral Analysis of Its Analogs on Motor Domain

Diána Martos, Bálint Lőrinczi, István Szatmári, László Vécsei, Masaru Tanaka

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: tryptophan; kynurenic acid; analogs; blood-brain barrier; drug design; drug delivery; exploratory behavior; motor skills, emotions; neuropsychiatry

Online: 20 February 2024 (15:12:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1222.v1

Navigating the Evolution of Game-Based Educational Approaches in Secondary STEM Education: A Decade of Innovations and Challenges

Chiara Fante, Fabrizio Ravicchio, Flavio Manganello

Subject: Social Sciences, Education Keywords: Game-Based Learning; Secondary STEM Education; Research Trends; Textual Analysis.

Online: 21 February 2024 (10:43:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1180.v1

Optical Design of a Wavelength Selective Switch Utilizing a Waveguide Frontend with Beamsteering Capability

Georgios Patsamanis, Dimitra Ketzaki, Dimitrios Chatzitheocharis, Konstantinos Vyrsokinos

Subject: Physical Sciences, Optics And Photonics Keywords: wavelength selective switch; optical phased array; 3D-FDTD; ray tracing; optical design

Online: 20 March 2024 (09:32:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1589.v1

Review of Sustainable Railway Station Design in Tropical Climate: Case of Thailand

Suppapon Tetiranont, Wannapol Sadakorn, Napong Tao Rugkhapan, Lapyote Prasittisopin

Subject: Engineering, Architecture, Building And Construction Keywords: railway station; architecture; design; tropical climate; structure

Online: 28 February 2024 (10:34:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1202.v1

Integrated Design System of Aircrafts Based on Generative Modeling Method

Wojciech Skarka, Rafał Nalepa, Robert Musik

Subject: Engineering, Aerospace Engineering Keywords: Generative model; Knowledge-Based Engineering; Design automation; Conceptual design; Aerospace Engineering; Computer Aided Design

Online: 17 May 2023 (07:14:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0250.v2

Investigating the Limitations of Fashion Research Methods in Applying a Sustainable Design Practice: A Systematic Review

Cristiano Pedroso-Roussado

Subject: Business, Economics And Management, Other Keywords: Fashion research; Sustainable fashion design; Fashion research methods; Sustainable design; ChatGPT

Online: 26 October 2023 (03:34:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0201.v1

Mind the Gap – Deciphering GPCR Pharmacology Using 3D Pharmacophores and Artificial Intelligence

Theresa Clare Noonan, Katrin Denzinger, Valerij Talagayev, Yu Chen, Kristina Puls, Clemens Alexander Wolf, Sijie Liu, Trung Ngoc Nguyen, Gerhard Wolber

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: ligand-based pharmacophores; structure-based pharmacophores; virtual screening; drug design; machine learning; molecular dynamics; de novo design

Online: 14 September 2022 (09:10:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0698.v1

Higher Education Instructors' Use, Perceptions, and Practices of Mobile Learning in Morocco

Youness Zidoun, Nabil Zary

Subject: Social Sciences, Education Keywords: Mobile learning; Integration framework; Design-based research

Online: 30 July 2021 (11:43:12 CEST)

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Background: In an age where information is generally accessible, most of the interest these days has focused on how accessible and convenient technology can be. So small and personal, mobile devices can transform our perception of learning by combining both mobility and convenience. Mobile learning is part of the digital learning landscape alongside e-learning and serious games. However, knowledge about effective design of mobile learning experiences remains of interest with a focus on appropriate design models and the embodiments that can be implemented to achieve the intended educational outcomes. Exploring the instructor's perspective on mobile learning is essential. Therefore, the aim of this study was to investigate the Moroccan instructors' perception and practice of mobile learning to inform the development of an ecologically valid mobile learning integration model. Methods: Higher education Instructors (n=41) were recruited to the study. The Moroccan instructors' perception and their experiences regarding their adoption of mobile learning were collected using an online survey. The analysis focused on their mobile use, perceived IT competency, and opinions on mobile learning. Results: We described most of the instructors' considerations regarding integrating mobile technologies into their teaching activities. We found that most of the mobile learning activities defined by the respondents corresponded to relatively advanced use of mobile devices. More promising, instructors have found innovative ways to use the educational potential of mobile devices. However, the prospect of mobile devices was still to challenge. No or poor Wi-Fi connection, number of devices or limited access, sometimes fees or applications incompatibility were identified as reasons and obstacles to mobile learning usage. Conclusion: Mobile learning is mostly perceived positively among Moroccan instructors allowing many applications and usage to enhance teaching and learning. In this study, a better understanding of aspects and factors influencing the integration of mobile learning in the Moroccan educational context is exposed, helping further the development of an ecologically valid mobile learning integration model. Future work on mobile learning should consider the highly paced evolution of mobile technologies, emphasizing the flexibility of integration frameworks to support instructors and learners.

Preprint ARTICLE | doi:10.20944/preprints202107.0708.v1

Designing in the Cultural Rural Landscape. A Teaching Opportunity to Experiment a Research-by-Design Process Applied to an Italian UNESCO Wine Site

Catherine Dezio, Can Zhang, Yilan Zhang, Davide Marino

Subject: Social Sciences, Anthropology Keywords: landscape design and planning; research-by-design; multifunctional agriculture

Online: 30 July 2021 (15:49:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0527.v1

Research Hotspots and Trends of Social Robot Interaction Design: A Bibliometric Analysis

Jianmin Wang, Yongkang Chen, Fusheng Jia, Fang You

Subject: Computer Science And Mathematics, Robotics Keywords: social robot; Interaction design; Bibliometric; VOSviewer; Citespace

Online: 7 September 2023 (09:27:28 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202312.1474.v1

A Design-Based Research Approach to Developing Teacher-Student Co-creation through Interactive E:books

Howard Scott, Matthew Smith

Subject: Social Sciences, Education Keywords: design innovation 2; co-creation 3; collaboration 4; interaction 5; speculative design 6; pedagogy 7. technology

Online: 19 December 2023 (14:58:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1617.v1

Mixed Methods Research in Public Health: Theoretical Underpinnings and Practical Applications

Amanuel Samago

Subject: Public Health And Healthcare, Other Keywords: Mixed methods research; public health; design; integration; philosophy

Online: 23 January 2024 (10:53:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0523.v1

Using Game Design to Teach Informatics and Society Topics in Secondary Schools

Fares Kayali, Vera Schwarz, Peter Purgathofer, Gerit Götzenbrucker

Subject: Social Sciences, Education Keywords: game-based learning; game design; project-based teaching; informatics and society, cybersecurity

Online: 26 July 2018 (16:38:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1109.v1

Estimating Wastewater Dilution Using Chemical Markers and Incomplete Flow Measurements: Application to Normalisation of SARS-CoV-2 Measurements

Owen D. Jones, Amy J. Baldwin, William B. Perry, Henry Wilde, Isabelle Durance, Davey L. Jones, Andrew Weightman

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: SARS-CoV-2; wastewater-based epidemiology; wastewater; dilution; flow normalisation; Bayesian

Online: 20 February 2024 (07:09:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0068.v1

Creating Family-Centred Support for Preschoolers with Developmental Disabilities in Low-Income Countries: A Rapid Review to Guide Practitioners

Roy McConkey

Subject: Public Health And Healthcare, Health Policy And Services Keywords: disability; preschool; children; family-centred; community-based; low income; inclusion; healthcare; education

Online: 2 April 2024 (10:06:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0026.v1

Propose of Mix Design Method for CO₂ Reduction Concrete Using the Regression Analysis

Tae Hyoung Kim

Subject: Engineering, Civil Engineering Keywords: concrete; sustainability; regression analysis mix design; CO2 emission; cost

Online: 3 August 2016 (06:05:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0121.v1

The Factors of Implementation Performance-Based Building Design on High Rise Residential Building in Indonesia

Sulfiah Dwi Astarini, Christiono Utomo

Subject: Engineering, Civil Engineering Keywords: performance-based building design; PBBD; high-rise residential.

Online: 7 July 2020 (09:46:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0220.v1

Genetic Optimization Algorithm for Metabolic Engineering Revisited

Tobias B. Alter, Lars M. Blank, Birgitta E. Ebert

Subject: Engineering, Bioengineering Keywords: metabolic strain design; heuristic optimization; constraint-based modeling

Online: 27 March 2018 (05:55:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1502.v1

Optimization of Process Parameters for Stir Casting of Tib2 Reinforced In-Situ Composites

Xavier Vivek Paul P, Xavier Sethu E, S. PERIYASAMY

Subject: Engineering, Mechanical Engineering Keywords: Metal Matrix Composite; Stir Casting Technique; Optimization; Box-Behnken Design and Process Parameters.

Online: 26 March 2024 (08:25:46 CET)

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Preprint REVIEW | doi:10.20944/preprints201911.0072.v2

Gridded Population Survey Sampling: A Review of the Field and Strategic Research Agenda

Dana R. Thomson, Dale A. Rhoda, Andrew J. Tatem, Marcia C. Castro

Subject: Social Sciences, Geography, Planning And Development Keywords: census; survey design; household survey; LMIC; WorldPop; LandScan

Online: 19 April 2020 (08:09:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0095.v1

A New Decision Support System for Analyzing Factors of Tornado Related Deaths in Bangladesh

Fahim Sufi, Edris Alam, Musleh Alsulami

Subject: Computer Science And Mathematics, Information Systems Keywords: Regression; AI based Tornado Analysis; Decision Support System; Mobile Application

Online: 9 May 2022 (03:15:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0029.v1

Research on Optimal Circuit Design and Charging Strategy of DC/DC Charger

Haodong Shen, Rong Yan, Junnan Zhou, Lin Pan

Subject: Engineering, Electrical And Electronic Engineering Keywords: DC/DC Charger; circuit design; charging strategy; working loss

Online: 3 January 2023 (09:37:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0150.v1

3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications

Ming-You Shie, Wen-Ching Chang, Li-Ju Wei, Yu-Hsin Huang, Chien-Han Chen, Yi-Wen Chen, Yu-Fang Shen

Subject: Chemistry And Materials Science, Biomaterials Keywords: water-based polyurethane; hyaluronic acid; cartilage tissue engineering; scaffold

Online: 30 November 2016 (04:28:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1433.v1

A Simple Machine Learning-Based Quantitative Structure-Activity Relationship Model for Predicting pIC50 Inhibition Values of FLT3 Tyrosine Kinase

Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: FLT3 Inhibitors; Ligand-based Drug Design; Computer-Aided Drug Design; QSAR Modeling; AML Treatment

Online: 25 March 2024 (08:47:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202206.0047.v1

Current Technology Developments Can Improve the Quality of Research and Level of Evidence for Rehabilitation Interventions

Bruno Bonnechère, Annick Timmermans, Sarah Michiels

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Rehabilitation; new technology; validation; study design; methods

Online: 3 June 2022 (11:12:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1290.v1

Analysis of the Magnetic Properties of Ultra-thin Grain-oriented Silicon Steel and Fe-based Amorphous Alloy from Power Frequency to Intermediate Frequency

Guang Ma, Ling Cheng, Yu Han, Chengxu He

Subject: Engineering, Electrical And Electronic Engineering Keywords: Ultra-thin grain-oriented silicon steel; Fe-based amorphous alloy; Epstein square ring; finite element method; loss

Online: 22 March 2024 (07:51:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0157.v1

Engineering Self-Adaptive Capabilities in Wireless Sensors Based on Control Algorithms and Model-Based Design Methodologies

Raúl Mario Del Toro Matamoros, Andrei Pruteanu, Rodolfo Elias Haber Guerra

Subject: Engineering, Control And Systems Engineering Keywords: self-adaption; wireless sensors; model-based design; control engineering

Online: 8 December 2022 (10:24:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0220.v1

How Size Matters: Diversity for Fragment Library Design

Yun Shi, Mark von Itzstein

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: diversity; fragment-based drug discovery; library design; library size

Online: 19 July 2019 (07:54:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0513.v1

Learning Transportation Sustainability through Human Powered Vehicle Design - A Ten-Year Experience at Politecnico di Torino

Paolo Baldissera, Cristiana Delprete

Subject: Engineering, Control And Systems Engineering Keywords: project based learning; human powered vehicles; sustainable transportation design

Online: 23 October 2018 (03:42:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1017.v2

Review of Nature-Based Echo-Hydraulic Aqua-Forest Technology for Coastal Resilience and Sea Level Rise Climate-Induced Adaptation

Olanrewaju Oladokun, Unberto Lazzaro

Subject: Environmental And Earth Sciences, Environmental Science Keywords: Nature-based solution; seaweed; seagrass; platform; coastal protection

Online: 16 April 2024 (10:46:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0050.v1

A Qualitative Research on Higher Education Students’ Knowledge, Attitudes and Behavior towards SDG 5, Gender Equality

Ana Lucía Ortega, Diana Kingsley-Thomas, Paula Suarez

Subject: Social Sciences, Anthropology Keywords: SDG; Gender Equality; project-based methodology

Online: 2 August 2021 (14:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0536.v1

Repetition is Important to Students and Their Understanding During Laboratory Courses that Include Research

Benjamin Wiggins, Leah Lily, Haley Sefi-Cyr, Caroline Dahlberg

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Course-based undergraduate research experience (CURE); repetition; iteration

Online: 26 January 2021 (11:37:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0112.v1

Evidence-Based Professionalism in Small Specialist HE Course Management – Reflexive Thoughts on Ongoing Research

Nieky van Veggel

Subject: Social Sciences, Education Keywords: HE course management； evidence-based practice； professionalism； practice

Online: 26 June 2017 (04:33:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0128.v1

Research-Based Training: Methodological Characteristics and Results of the Analysis of Educational Programs

Roman Pavliuk, Tetiana Liakh, Olga Bezpalko, Nataliia Klishevych

Subject: Social Sciences, Education Keywords: research-based training; methodological characteristics; development of research skills.

Online: 26 September 2017 (08:10:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0270.v1

Infeasibility and Structural Bias in Differential Evolution

Fabio Caraffini, Anna Kononova, David Corne

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: structural bias, algorithmic design, differential evolution, population-based algorithms, optimisation

Online: 24 April 2019 (12:16:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0199.v1

Nest Design and Breeding Success: Replicability of Methodologies and Research Findings in Avian Model Species

Marcel Lambrechts, Charles Deeming

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Nest design; Breeding success; Nest-box; Cavity-nesting birds; Replicability

Online: 5 March 2024 (09:12:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0132.v1

Searching for a Theory that fits the Data: A Personal Research Odyssey

Katarina Juselius

Subject: Business, Economics And Management, Econometrics And Statistics Keywords: Cointegrated VAR methodology, Linking theory and evidence, Empirically based macroeconomics.

Online: 9 July 2018 (11:34:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1335.v1

Article Review: Role and Functionality of Ingredients in Plant-Based Meat Analogue Burgers

Gil Vila-Clarà, Anna Vila-Martí, Laia Vergés-Canet, Miriam Torres-Moreno

Subject: Biology And Life Sciences, Food Science And Technology Keywords: meat analogues; plant-based meat; plant-based burgers; functionality; food technology innovation; clean-label ingredients; composition; sustainability

Online: 22 March 2024 (11:00:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0376.v1

Computational Strategies to Combat COVID-19: Useful Tools to Accelerate SARS-CoV-2 and Coronavirus Research

Franziska Hufsky, Kevin Lamkiewicz, Alexandre Almeida, Abdel Aouacheria, Cecilia Arighi, Alex Bateman, Jan Baumbach, Niko Beerenwinkel, Christian Brandt, Marco Cacciabue, Sara Chuguransky, Oliver Drechsel, Robert D. Finn, Adrian Fritz, Stephan Fuchs, Georges Hattab, Anne-Christin Hauschild, Dominik Heider, Marie Hoffmann, Martin Hölzer, Stefan Hoops, Lars Kaderali, Ioanna Kalvari, Max von Kleist, René Kmiecinski, Denise Kühnert, Gorka Lasso, Pieter Libin, Markus List, Hannah F. Löchel, Maria J. Martin, Roman Martin, Julian Matschinske, Alice C. McHardy, Pedro Mendes, Jaina Mistry, Vincent Navratil, Eric Nawrocki, Áine Niamh O'Toole, Nancy Palacios-Ontiveros, Anton I. Petrov, Guillermo Rangel-Piñeros, Nicole Redaschi, Susanne Reimering, Knut Reinert, Alejandro Reyes, Lorna Richardson, David L. Robertson, Sepideh Sadegh, Joshua B. Singer, Kristof Theys, Chris Upton, Marius Welzel, Lowri Williams, Manja Marz

Subject: Biology And Life Sciences, Virology Keywords: virus bioinformatics; SARS-CoV-2; sequencing; epidemiology; drug design; tools

Online: 23 May 2020 (11:01:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1746.v1

The Development of an Oral Health Nursing Tool in Patients with a Psychotic Disorder: A Human-Centered Design with a Feasibility Test

Sonja Kuipers, Stynke Castelein, Linda Kronenberg, Job van ’t Veer, Nynke Boonstra

Subject: Social Sciences, Other Keywords: oral health; nursing; mental health; psychotic disorder; human-centered design

Online: 28 March 2024 (15:37:34 CET)

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Patients with a psychotic disorder frequently report oral health problems, while mental health nurses (MHNs) seem not to be fully aware of these problems and the risk factors. Therefore, this study aims to develop supportive tools for MHNs regarding oral health to increase sensitization among MHNs and to provide MHNs with knowledge to recognize (potential) oral health problems in patients with a psychotic disorder. We used a human-centered design in which the user, MHNs as well as experts by experience, were placed in the centre of the research process. Problems and needs in MHNs working with patients with a psychotic disorder were addressed. To identify key issues of problem as well as the needs in terms of resources, we started with focus groups (n = 9). We analysed the data thematically based on context of patients and MHNs in practice regarding oral health, preferred oral health tools focused on MHN, and intended outcomes of tools. A Multi Criteria Decision Matrix was developed and analysed (n = 9) to identify the most optimal and viable solution based on established criteria and issues that are prevalent in the work of MHNs. Most promising result was the development of a brochure with an awareness screener. The brochure with awareness screener was developed as a low-fidelity prototype for MHNs regarding oral health in patients with a psychotic disorder, based on the latest scientific evidence. After testing it, the feasibility was tested through semi-structured interviews (n=19). MHNs and experts by experience were satisfied with the tool and provided recommendations for adjustments to the content. Significant augmentations to the brochure include a clinical lesson and a toothbrush with toothpaste for patients. We can conclude that a brochure with an awareness screener is feasible for MHNs. Future steps aiming to further refine and optimize care processes for oral health tools in MHNs, should take refining eligibility criteria for psychiatric populations and the language level of the target group of a tool into account.

Preprint ARTICLE | doi:10.20944/preprints202009.0006.v2

Plausible Blockers of Spike RBD in SARS-CoV2 – Molecular Design and Underlying Interaction Dynamics from High-Level Structural Descriptors

Sankar Basu, Devlina Chakravarty, Dhananjay Bhattacharyya, Pampa Saha, Hirak K. Patra

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; SARS-CoV-2; protein design; complementarity; competitive inhibitor; homology-based threading in rational protein design

Online: 4 March 2021 (10:14:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0478.v2

Brief Overview. Role of Computation Biology & Bioinformatics in Drug Design

Ghafran Ali, kanza Ashfaq

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Bioinformatics; Drug Design; Small Organic Molecule; Target identification; Web-based Server

Online: 25 July 2020 (17:50:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0150.v1

Cloud-Based CAD Parametrization for Design Space Exploration and Design Optimization in Numerical Simulations

Joel Guerrero, Luca Mantelli, Sahrish B. Naqvi

Subject: Engineering, Control And Systems Engineering Keywords: CFD; numerical optimization; CAD parametrization; cloud-based; design space exploration; SSIM

Online: 9 March 2020 (09:50:23 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0017.v4

Propositions for Confidence Interval in Systematic Sampling on Real Line

Mehmet Niyazi Çankaya

Subject: Computer Science And Mathematics, Mathematics Keywords: biomedical imaging; covariogram; design-based stereology; estimation of volume; systematic sampling

Online: 15 September 2016 (05:18:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1555.v1

Reporting on the Development of a Web-Based Design Management Prototype Dashboard Achieved through a Design Science Research (DSR) Approach

Barry Gledson, Kay Rogage, Anna Thompson, Hazel Ponton

Subject: Engineering, Architecture, Building And Construction Keywords: Design Management; Design Science Research (DSR); digital innovations in construction; impact of digital technologies on construction processes; Information management; Information technology; Innovation

Online: 20 December 2023 (11:56:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0387.v1

Study on the mechanical property and design method of frame-unit bamboo culm members based on semi-rigid joints

Guojin Wang, Xin Zhuo, Shenbin Zhang, Jie Wu

Subject: Engineering, Civil Engineering Keywords: frame-unit prefabricated bamboo culm structure; semi-rigid joint; mechanical property; numerical simulation methods; design method.

Online: 7 March 2024 (09:37:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0268.v1

A Time and a Place for Everything: Aligning Community-Engaged Research to Context

Jonathan K. London, Krista A. Haapanen, Ann Backus, Savannah Mack, Marti Lindsey, Karen Andrade

Subject: Social Sciences, Geography, Planning And Development Keywords: environmental health science; community engagement; community based participatory research; community-university partnerships

Online: 20 December 2019 (07:07:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1172.v1

Study of the Bacterial, Fungal, and Archaeal Communities Structures near the Bulgarian Antarctic Research Base “St. Kliment Ohridski” on Livingston Island, Antarctica

Vesselin V. Doytchinov, Slavil Peykov, Svetoslav G. Dimov

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: amplicon-based metagenomics; polar microorganisms; environmental microbiomes

Online: 16 January 2024 (13:50:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0325.v1

A Bibliometric Analysis of Research on Membrane Coated Electrodes in the 2001-2019 Period: Potential Application to CO2 Capture and Utilization

Clara Casado-Coterillo, Aitor Marcos-Madrazo, Aurora Garea, Angel Irabien

Subject: Chemistry And Materials Science, Electrochemistry Keywords: Keywords; CO2; conversion; bibliometrics; electrode design; CO2RR; membrane; flow cell

Online: 15 September 2020 (04:45:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0927.v1

The Effect of Model Similarity on Exercise Self-Efficacy Among Adults Recovering from a Stroke: A Mixed-Method Single Case Experimental Research Design

Olivia Pastore, François Jarry, Jammy Zou, Jennifer R. Tomasone, Luc J. Martin, Véronique Pagé, Shane Sweet

Subject: Social Sciences, Psychology Keywords: mixed-method; modelling; peers; single-case design; self-efficacy; stroke

Online: 14 November 2023 (15:21:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0392.v1

From Creative, Reflective, Practice to Affective Reflexivity as an Art Research Methodology

Debbie Michaels

Subject: Arts And Humanities, Art Keywords: Reflective art practice; affective reflexivity; art-based research; art therapy; response art; embodied observation; interdisciplinarity; ethics

Online: 7 November 2023 (11:31:00 CET)

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A capacity to reflect on experience and learn through it (reflective and reflexive practice) is deemed an essential part of ethical practice and research. Challenging traditional research approaches this arts-based, inter-disciplinary, Ph.D. project explores artistic practice as a research methodology, and how learning through experiences of ‘making’ things may enhance and amplify our understanding of the more affective aspects of human situations and experience. Grounded in the author’s artistic practice and learning through experiences of ‘making’, the author assembles and adapts frames from psychoanalysis, art (psycho)therapy, and the arts with/through which to observe and document their experience of an organisational situation. Describing the development of their method in three phases, analysis takes place through returning to revisit and rework artistic material produced, and engaging in conversation with the emergent material and others in response. Results take the form of artworks and artistic projects, including documentation of process. Emergent threads draw attention to the speculative, entangled, and affective nature of the research process, the reflexivity generated through moving and handling material, and the reflexive work of undergoing, foregrounding an ethics of responsibility, attention, and care for/of the body. As a space for imaginative encounter and performative enactment, and a site for reflexivity through which one may be pressed to notice and feel more acutely, the author argues that the research value resides in the capacity of this method to embrace complex relationalities, and engage our affective, ethical sensibilities in ways that may not emerge through more traditional approaches to reflective/reflexive practice(s). This has implications for both art therapy practice and research, amplifying the learning opportunities afforded by moving, modifying, and assembling things differently, the embodied ‘work’ of art as a method of enquiry, the cultural sensitivity of documentary fragments captured in/through various media and voices, and the value of collaborative endeavours where meaning is co-constructed in conversation.

Preprint ARTICLE | doi:10.20944/preprints202309.0329.v2

Exploring the Use of the AEDET Hospital Evaluation Toolkit to Create a Better Healing Environment for Cancer Patients Beyond the Global North

Bedia Tekbiyik Tekin, Ozgur Dincyurek

Subject: Arts And Humanities, Architecture Keywords: hospitals; Environmental design; environmental comfort; healing environment; patient-centred care; evidence-based design; architectural space quality; health and wellbeing outcomes

Online: 25 September 2023 (07:05:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0337.v1

Pre-Intervention Effects of a Community-Based Intervention Targeting Alcohol Use (LEF); The Role of Participatory Research and Publicity

Ina Koning, Vincent G. van der Rijst, John B. F. de Wit, Charlotte De Kock

Subject: Social Sciences, Psychology Keywords: participatory research; pre-intervention; community-based intervention; alcohol use; adolescents

Online: 14 July 2021 (14:04:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1221.v1

Towards Zero-Carbon Buildings: Challenges and Opportunities from Reversing the Material Pyramid

Matteo Francesco Ruta, Francesco Pittau, Gabriele Masera

Subject: Engineering, Architecture, Building And Construction Keywords: carbon neutral construction; material diets; biogenic carbon; bio-based materials; sustainable building design

Online: 18 April 2024 (07:51:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1972.v1

Integrating Aerial and 3D Data into a Data-Driven Decision-Making Workflow for Nature-Based Stormwater Solutions

Harry Edelman, Lasse Rosen, Emil Nyman, And Piia Leskinen

Subject: Arts And Humanities, Architecture Keywords: aerial; data; drones; urban; nature-based; photogrammetry; design; software; decision-making; stormwater; management

Online: 1 November 2023 (02:43:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0619.v1

A Course-Based Undergraduate Research Experience for High-Throughput Reverse Genetic Studies in Arabidopsis Thaliana with CRISPR-Cas9

Alison Mills, Venkateswari Jagannatha, Alejandro Cortez, Michael Guzman, James Burnette, Matthew Collin, Berenise Lopez-Lopez, Susan Wessler, Jaimie Van Norman, David Nelson, Carolyn Rasmussen

Subject: Biology And Life Sciences, Plant Sciences Keywords: CRISPR-Cas9; course-based undergraduate research experience; CURE; remote learning; plant biology

Online: 27 August 2020 (12:29:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0539.v1

Genotype Fingerprints Enable Fast and Private Comparison of Genetic Testing Results for Research and Direct-to-Consumer Applications

Max Robinson, Gustavo Glusman

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: computational genomics; genome comparison; algorithms; genetic testing; privacy; direct-to-consumer; study design; population genetics

Online: 31 August 2018 (04:59:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0267.v1

A single-case design investigation for measuring the efficacy of Gestalt therapy to treat depression in older adults with dementia in Italy and in Mexico: a research protocol

Alessandra Merizzi, Rosanna Biasi, José Fernando Álvarez Zamudio, Margherita Spagnuolo Lobb, Sara Santini

Subject: Social Sciences, Psychology Keywords: Gestalt therapy; dementia; depression; single-case experimental design; psychosocial interventions

Online: 19 January 2022 (09:32:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0199.v1

In Silico Search for Drug Candidates Targeting the PAX8–PPARγ Fusion Protein in Thyroid Cancer

Kaori Sakaguchi, Yoshio Okiyama, Shigenori Tanaka

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: follicular thyroid neoplasia; PAX8– PPARγ fusion; fusion protein; structure-based drug design

Online: 3 April 2024 (07:24:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1265.v1

How Technology-Based Interventions Can Sustain Ageing Well in the New Decade through the User-Driven Approach

Magdalen Velciu, Luiza Spiru, Mircea Dan Marzan, Eva Reithner, Simona Geli, Barbara Borgogni, Oana Cramariuc, Irina G. Mocanu, Jerzy Kołakowski, Jaouhar Ayadi, Margherita Rampioni, Vera Stara

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: active and healthy ageing; intrinsic capacity; user-centered design; eHealth literacy; technology-based interventions

Online: 18 May 2023 (04:48:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0381.v1

Automated Conditional Screening of Escherichia Coli Knockout Mutants in Parallel Adaptive Fed-Batch Cultivations

Sebastian Hans, Benjamin Haby, Niels Krausch, Barz Tilman, Peter Neubauer, Mariano Nicolas Cruz-Bournazou

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: high throughput screening; rapid phenotyping; model-based experimental design; Escherichia coli; automated bioprocess development

Online: 17 September 2020 (07:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0089.v1

Adapted Business Model Canvas Template and Primary Market Research for Project-Based Learning on Management of Slurry

Alejandro Moure Abelenda, Farid Aiouache, Daniel Moreno-Mediavilla

Subject: Social Sciences, Education Keywords: Educational action research; unregistered community design; shared intellectual property; cooperative learning; K-16 students; net-zero emissions

Online: 6 March 2023 (04:35:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0874.v2

Co-Design/Co-Development and Evaluation of an Online Frailty Check Application for Older Adults: Participatory Action Research with Older Adults

Bo-Kyung Son, Takahiro Miura, Ken-ichiro Yabu, Yuka Sumikawa, Dongyool Kim, Weida Lyu, Yingxue Yang, Moeko Tanaka, Tomoki Tanaka, Yasuyo Yoshizawa, Katsuya Iijima

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: online frailty check application; older adults; co-design; co-development; reliability; participatory action research

Online: 16 May 2023 (05:25:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0409.v1

Design Process for a Birthing Bed, Based in User Hierarchy: Promoting Improvement in User Satisfaction

Fabiola Cortes_Chavez, Alberto Rossa-Sierra, Elvia Luz Gonzalez Muñoz

Subject: Engineering, Control And Systems Engineering Keywords: Design; birthing bed; user centered design; medical design; user hierarchies; design process; design; education

Online: 23 September 2021 (12:55:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0438.v1

Exploring an AM-Enabled Combination-of-Functions Approach for Modular Product Design

Charul Chadha, Kathryn Crowe, Christina Carmen, Albert Patterson

Subject: Engineering, Industrial And Manufacturing Engineering Keywords: Additive manufacturing; modular design; design-for-manufacturability; sustainable design; design optimization; product re-design

Online: 21 September 2018 (15:23:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0543.v1

Research and Application of a High-pressure, Large-flow and High-water-based Mining Digitally Controlled Unloading Valve

Xiaochun Zhang, Jiyun Zhao

Subject: Engineering, Control And Systems Engineering Keywords: mining unloading valve; high pressure; large flow; high-water-based fluid; digitally controlled unloading valve

Online: 8 September 2023 (05:09:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1838.v1

A Coupled Simulated Annealing and Particle Swarm Optimization Reliability-Based Design Optimization Strategy under Hybrid Uncertainties

Shiyuan Yang, Hongtao Wang, Yihe Xu, Yongqiang Guo, Lidong Pan, Jiaming Zhang, Xinkai Guo, Debiao Meng, Jiapeng Wang

Subject: Engineering, Mechanical Engineering Keywords: Particle swarm optimization algorithm; Reliability-based design and optimization; Simulated annealing algorithm; Most probable point

Online: 30 October 2023 (07:14:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0045.v1

Enhancing Starch-Based Packaging Materials: Optimization of Plasticizers and Process Parameters

Yue Wu, Rongji Tang, Anfu Guo, Xiaodong Tao, Yingbin Hu, Xianliang Sheng, Peng Qu, Shaoqing Wang, Jianfeng Li, Fangyi Li

Subject: Engineering, Mechanical Engineering Keywords: Plasticizer plasticizing; Thermoplastic starch; Box–Behnken design; Response surface method; Starch-based composite packaging material

Online: 1 August 2023 (10:18:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0771.v1

Solder Alloy Design: Investigation of Predictive Models for Tensile Properties Based on Different Alloy Compositions and Microstructures

Vítor Covre Evangelista da Silva, Guilherme Gouveia, Bismarck Luiz Silva, Vera Lucia Damasceno Tomazella, José Eduardo Spinelli

Subject: Engineering, Metallurgy And Metallurgical Engineering Keywords: Solder Alloys; Mechanical Properties; Alloy Design; Sn-based Alloys; Data Science; Predictive models; Machine Learning

Online: 12 June 2023 (05:23:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0288.v1

RivEr/Generation_LAB. Linking Resilience with Inclusiveness in the Urban Built Environment of Rome

Carmela Mariano, Francesca Rossi

Subject: Arts And Humanities, Architecture Keywords: Resilience, climate change, vulnerability, water management and urban planning, environmental technological design, nature-based solutions

Online: 16 December 2022 (01:59:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202205.0244.v1

Automatic Failure Mode and Effect Analysis of Electronic Fuel Injection Model

Dongwoo Lee, Dongmin Lee, Jongwhoa Na

Subject: Engineering, Automotive Engineering Keywords: failure mode and effect analysis (FMEA); model-based design; automatic generation tool; fault injection simulation

Online: 18 May 2022 (12:40:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0125.v1

Towards the de Novo Design of HIV-1 Protease Inhibitors Based on Natural Products

Ana L. Chávez-Hernández, K. Eurídice Juárez-Mercado, Fernanda I. Saldívar-González, José L. Medina-Franco

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: artificial intelligence; de novo design; fragment-based drug discovery; HIV-1 inhibitors; pseudo natural products

Online: 8 November 2021 (09:23:49 CET)

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Preprint DATASET | doi:10.20944/preprints202003.0011.v1

Extracting the Interfacial Electrostatic Features from Experimentally Determined Antigen and/or Antibody-Related Structures inside Protein Data Bank for Machine Learning-Based Antibody Design

Wei Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: antigen-antibody complex structure; interfacial electrostatic feature; Machine Learning-Based Antibody Design; Protein Data Bank

Online: 1 March 2020 (12:39:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0366.v1

Smartphone-Based Color Evaluation of Passive Samplers for Gases: A Review

Kanokwan Kiwfo, Kate Grudpan, Andreas Held, Wolfgang Frenzel

Subject: Environmental And Earth Sciences, Pollution Keywords: Passive gas sampling; diffusive sampling; ambient air measurements; immission rate; smartphone-based color evaluation; RGB color space; colorimetric gas sensors

Online: 6 March 2024 (13:39:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0086.v1

Research on the Application of NbS in Watershed Ecological Restoration: A Case Study of Jiulong River Watershed Shan-Shui Initiative

Wei Li, Rui Sun, Ye Tian

Subject: Environmental And Earth Sciences, Ecology Keywords: watershed ecological restoration; nature-based solutions; Shan-Shui Initiative; scenario evaluation; adjustment of measures

Online: 2 November 2023 (07:40:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0485.v1

Application of Pattern Language for Game Design in Pedagogy and Design Practice

Christopher Aaron Barney

Subject: Computer Science And Mathematics, Software Keywords: game design, design patterns; pattern language; design pattern application; design pattern creation

Online: 21 July 2021 (11:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0161.v1

Research on the Application of CGAN in the Design of Historic Building Facades in Urban Renewal—Taking Fujian Putian Historic Districts as an Example

Hongpan Lin, Linsheng Huang, Yile Chen, Liang Zheng, Minling Huang, Yashan Chen

Subject: Engineering, Architecture, Building And Construction Keywords: machine learning; conditional generative adversarial network (CGAN); historic district; facade design; decoration style; urban renewal

Online: 3 May 2023 (14:50:45 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202004.0043.v1

Maternal Fasting or Fluid Abstention Does Not Significantly Affect the Macronutrient Composition of Human Milk: Clinical and Clinical Research Relevance

Karel Allegaert, anne smits

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: lactation; physiology-based lactation models; drug exposure prediction; fasting; drug safety; newborn; infant; human milk

Online: 6 April 2020 (09:11:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0726.v1

An Impact-Centered Sustainable Positive Experience Design Model

Chunmao Wu, Xuan Wang

Subject: Social Sciences, Psychology Keywords: Impact-centered design; sustainable design; positive experience; design model

Online: 13 October 2023 (07:11:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0168.v1

Dimensions of knowledge in prototyping: a review and characterisation of prototyping methods and their contributions to design knowledge

Ricardo Real

Subject: Engineering, Automotive Engineering Keywords: Design knowledge, Knowledge dimensions, prototyping, design cognition, design thinking

Online: 7 June 2021 (11:30:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0428.v1

Hybrid Spreadable Cheese Analogues with Faba Bean and Tenebrio molitor Flours: Optimisation Using Desirability-Based Mixture Design

Laura Garcia-Fontanals, Raquel Llorente, Juanjo Valderrama, Sergio Bravo, Clara Talens

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: hybrid cheese; faba bean protein; insect protein; desirability-based mixture design; spreadability texture analysis; sensory analysis

Online: 27 February 2023 (01:44:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0099.v1

Comparative Study of Structural Reliability Assessment Methods for Fixed Offshore Structures

E. Mat Soom, M.K. Abu Husain, N.I. Mohd Zaki, N.A. Mukhlas, S.Z.A. Syed Ahmad, N.U. Azman, Gholamhossein Najafian

Subject: Engineering, Automotive Engineering Keywords: offshore structures; reliability-based design assessment; global ultimate strength assessment; reserve strength ratio; probability of failure

Online: 3 August 2021 (16:19:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0264.v1

Sustainable and Responsible Design Education: Tensions in Transitions

Joanna Boehnert, Matt Sinclair, Emma Dewberry

Subject: Arts And Humanities, Architecture Keywords: Design for Sustainability; Responsible Design; transdisciplinary design; design education; social design; ecological literacy; transition; disciplinary fragility; defuturing; sustainability

Online: 19 May 2022 (16:11:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0108.v1

Reaching, Engaging and Advancing Research (REAR); An Assessment of Health Managers’ Skills and Knowledge in Data Management, Analysis, Utilization, and Dissemination Kenya, Tanzania and Rwanda

Peter Memiah, Tristi Ah Mu, Shreya Madhavaram, Caroline Kingori, Courtney Cook, Sarah Dawson, Hannah Funk, Jackson Sebeza, Michelle Mwangi, Mtebe Majigo, Samuel Muhula, Wairimu Mwangi, Vernon Mochache, Kevin Owour, John Paul Oyore, Eric Remera, Sabin Nsanzimana, Claude Kumalija, Carol Ngunu

Subject: Medicine And Pharmacology, Other Keywords: Data Management; Utilization and Analysis; Capacity Building; Health professionals; Workforce Development; Evidence Based

Online: 7 June 2018 (08:54:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1257.v1

Restorative Environment and Well Being in a Hospital through Landscape Design

vishakha verma, I P Singh

Subject: Engineering, Architecture, Building And Construction Keywords: Architectural Design; Built environment; Sustainability; Psychology of design; Behavioural Design

Online: 19 September 2023 (07:23:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0867.v2

A Sustainable Digital Transformation in Healthcare and Well-Being: An Overview, Integration, Design and Security Challenges, Blockchain Technology, Applications, and Future Research Directions

Faisal Hameed, Khizar Hameed

Subject: Business, Economics And Management, Other Keywords: sustainability; sustainable development goal; healthcare; information and communication technology; blockchain; security and privacy; design goal; society; environmental; financial)

Online: 19 September 2023 (15:31:09 CEST)

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Good health and well-being is one of the essential SDGs that ensure healthy lives and promote well-being for all ages and further entails providing substantial medical services to the public at low cost and with minimal adverse effects on the environment. Information and communication technologies (ICTs) have taken on an increasingly important function as significant facilitators of healthcare reform, with the goals of enhancing access to health services, the quality of treatment provided, and the overall productivity of the healthcare system. However, the integration of ever-increasing ICT technologies into the healthcare systems, also referred to as digital transformation, is not a straightforward process, but it comes with different types of challenges from integration level to application design level and security level. Although several studies have been proposed to address the integration of ICT technologies into healthcare systems, there is still a need for a comprehensive research study on the integration and design challenges, security and privacy challenges, application areas, and possible positive and negative impacts. Therefore, this paper contributes as the research literature study covering an important SDG, "Good health and well-being," and its digital transformation, along with summarising our research findings in a detailed and taxonomical way. To start with, firstly, we present a detailed comparison of existing studies on healthcare and well-being, mainly focusing on integrating ICT technologies in healthcare in terms of sustainable aspects, security and privacy challenges, design and integration challenges, E-health-related applications, and future directions. We also present an overview and the need for digital transformation in healthcare, discuss its significant components, highlight E-health's importance and benefits, explore its integration and design challenges, and categorise the security and privacy challenges. Next, we present an in-depth discussion on the role of Blockchain technology as today's leading technology in E-health, discussing Blockchain technology and its characteristics, highlighting its benefits, and describing the possible types of Blockchain-based E-health use cases. Furthermore, we discuss the positive and negative impact of ICT integration along with identifying open issues and challenges of integrating ICT technologies into the healthcare systems and discuss future research directions, which provide the strength for researchers to address the issues in future solutions.

Preprint ARTICLE | doi:10.20944/preprints202305.0552.v1

Predictive Cell-Culture Time-Evolution Based on Electric Models

Juan Alfonso Serrano, Pablo Perez, Paula Daza, Gloria Huertas, Alberto Yúfera

Subject: Engineering, Bioengineering Keywords: Bioimpedance; Cell Culture; Computer Aided Design (CAD); electric model; Fractional Order (FO); Microelectrode; Oscillation Based Test (OBT)

Online: 9 May 2023 (03:45:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0296.v1

Plasmodium falciparum Dihydroorotate Dehydrogenase, Fragment-based Drug Design, 2D-QSAR, DFT Calculation, Lead Optimization, Induced Fit Docking

Opeyemi Iwaloye, Olusola Elekofehinti, Femi Olawale, Prosper Chukwuemeka, Kikiowo Babatomiwa, Ibukun Folorunso

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Plasmodium falciparum dihydroorotate dehydrogenase; fragment-based drug design; 2D-QSAR; DFT calculation; Lead optimization; Induced Fit docking

Online: 20 December 2021 (09:39:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201609.0085.v2

Modeling and Simulation of Passenger Flow Distribution in Urban Rail Transit Hub Platform

Long Gao, Limin Jia

Subject: Computer Science And Mathematics, Computational Mathematics Keywords: passenger flow distribution model; simulation design; performance evaluation; passenger flow volume; service level; urban rail transit hub platform

Online: 2 December 2016 (07:52:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1352.v1

Optimal Design and Development of Magnetic Field Detection Sensor for AC Power Cable

Yong Liu, Yuepeng Xin, Boxue Du, Xingwang Huang, Jingang Su

Subject: Engineering, Electrical And Electronic Engineering Keywords: Single-core AC high-voltage cable; Magnetic field sensor; Optimal design; Magnetic core; Coil; Amplifying circuit

Online: 22 March 2024 (06:35:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0272.v1

Biology of Creativity: A Nondesign-Inspired Model to Enhance Creativity and Innovation Skills

Antonio Cruz Rodrigues, Cristiano Pedroso-Roussado, Joao Cunha, Ana Jorge

Subject: Arts And Humanities, Architecture Keywords: design education; design activity; design model(s); analogical reasoning; bio-inspiration

Online: 15 March 2023 (08:47:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0296.v1

The Use of Patterns as an Urban Design Approach

Hernan Casakin

Subject: Arts And Humanities, Architecture Keywords: design patterns; urban design; problem-solving; creativity; urban design education; teamwork

Online: 17 September 2018 (10:01:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0047.v2

Design Is How We Change the World! Can We Do It in Socially, Environmentally and Economically Acceptable Ways? Synthesizing Design Tools for This Utopian Concept

Kumaraswamy Ponnambalam, Abbas Seifi, Jamshid Mousavi

Subject: Social Sciences, Decision Sciences Keywords: design for society; design for sustainability; design under uncertainty; circular design; donut economics; life cycle analysis

Online: 5 August 2020 (04:50:02 CEST)

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Since the beginning, humans advanced their civilization by making better tools to improve their lives. Tools and products were designed for better living considering manufacturing issues, cost and time as predominant criteria. It has become clear that not considering environment and society, both at local/global levels, has now become a major impediment affecting living conditions on a large portion of the Earth and in many societies. Design methodologies should lead to creative solutions with consideration to engineering and economics for practicality but also to environmental and social constraints for sustainability. We propose a comprehensive design methodology based on multidisciplinary design to include the knowledge of humanities, environmentalists, science and engineering, and allowing for experts’ inputs from these areas to provide a holistic approach to engineering design . For example, experts in humanities are expected to interact with stakeholders to evaluate their value systems to provide guidance for the design. The methodology that we synthesize is new and combines (i) Societal level impacts at all scales, (ii) Environmental impacts and (iii) Engineering design with economic impacts, including uncertainty considerations. The proposed design methodology is called Social-Environmental-Economical-Engineering Framework (SEEEF). It can utilize concepts and tools such as Circular Design, Doughnut Economics, design based on environmental life cycle analysis, among others. SEEEF is quantity based and provides steps for evaluating any project or product in an objective manner and will help train engineers in design for sustainability. It also provides non-engineers with a significant role in design to increase their understanding of the hard constraints of engineering. Ultimately, SEEEF allows society to take an informed decision considering short/long term and local/global impacts of the design and the pertinent uncertainties.

Preprint ARTICLE | doi:10.20944/preprints202403.1318.v1

Arguments for a Community Based Approach to the Geothermal Energy Development

Katarzyna A. Kurek, Jacek Strojny, Johan van Ophem

Subject: Business, Economics And Management, Other Keywords: geothermal energy; endogenous growth; green transition; energy based local economic system; geothermal community

Online: 21 March 2024 (15:00:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1155.v1

Solving the Problem of Reducing the Audiences’ Favor Towards an Educational Institution by Using a Combination of Hard and Soft Operations Research Approaches

Xu Wenjing, Seyyed Ahmad Edalatpanah, Ali Sorourkhah

Subject: Business, Economics And Management, Business And Management Keywords: Problem solving; Wicked problem; Hard OR; Soft OR; Problem Structuring Methods; Decision-Making; Subdivision-based PSM

Online: 15 June 2023 (14:06:11 CEST)

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