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Preprint ARTICLE | doi:10.20944/preprints202108.0456.v1

Effective Connectivity between Major Nodes of the Limbic System, Salience and Frontoparietal Networks Differentiates Schizophrenia and Mood Disorders from Healthy Controls

Sevdalina Kandilarova, Drozdstoy Stoyanov, Rositsa Paunova, Anna Todeva-Radneva, Katrin Aryutova, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychiatry; effective connectivity; depression; salience network; schizophrenia; mood disorders

Online: 23 August 2021 (14:57:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0654.v1

A Hybrid Deep Learning Model to Predict the Impact of COVID-19 on Mental Health form Social Media Big Data

Tapotosh Ghosh, Md. Hasan Al Banna, Md. Jaber Al Nahian, Kazi Abu Taher, M Shamim Kaiser, Mufti Mahmud

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: COVID-19; Mental Health; Depression; Big data; Social media.

Online: 28 June 2021 (13:50:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0171.v1

The Influence of Social Family Support on Depression, Anxiety and Quality of Life Among Women with Breast Cancer: Literature Review

Tutik Rahayu, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: social support; anxiety; depression; quality of life; breast cancer

Online: 6 April 2021 (11:31:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0783.v1

In Schizophrenia, Depression and Anxiety Symptoms Are Driven by Immune-Inflammatory Pathways.

Abbas Almulla, Khalid Al-Rawi, Michael Maes, Hussein Kadhem Al-Hakeim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; anxiety; melancholia; inflammation; neuro-immune; physiosomatic; biomarkers; schizophrenia

Online: 31 December 2020 (09:42:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0283.v1

Nomothethic Network Psychiatry: A Bottom-Up Approach to Build Data-Driven Disease Models Based on Risk-Resilience, Adverse Outcome Pathways, and Phenome Scores, and to Discover New Biosignature-Based Classifications

Drozdstoy Stoyanov, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: psychiatry; major depression; mood disorders; schizophrenia; antioxidants; oxidative stress

Online: 13 October 2020 (14:07:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0636.v1

Analysis of Stress, Anxiety and Depression of Children During COVID-19

Samir Bandyopadhyay, Shawni Dutta

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: COVID-19; stress; mental anxiety; depression; children and attributes

Online: 28 August 2020 (11:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0067.v1

The Influence of Nonpharmacological Complex Therapy Conducted at Community Day-Care Center on the Cognitive Functions and Mood in Older Adults

Agnieszka Gorzkowska, Izabela Zacharska-Quiaum, Joanna Cholewa, Jarosław Cholewa

Subject: Social Sciences, Behavior Sciences Keywords: cognition; depression; agigng; elderly; nonpharmacological therapy; community day-care

Online: 5 May 2020 (10:32:05 CEST)

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Working Paper ARTICLE

Development of a Novel Neuro-Immune and Opioid-Associated Fingerprint with a Cross-Validated Ability to Identify and Authenticate Unknown Patients with Major Depression: Far Beyond Differentiation, Discrimination and Classification

Hussein Al-Hakeim, Suhaer Al-Fadhel, ARAFAT ALDUJAILI, André F. Carvalho, Sira Sriswasdi, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: supervised learning, major depression, cytokines, inflammation, neuro-immune, opioids

Online: 25 March 2019 (10:14:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0064.v1

Few Sex Differences in Hospitalized Suicide Attempters Aged 70 and Above

Stefan Wiktorsson, Therese Rydberg Sterner, Madeleine Mellqvist Fässberg, Ingmar Skoog, Anne Ingeborg Berg, Paul Duberstein, Kimberly Van Orden, Margda Waern

Subject: Social Sciences, Psychology Keywords: sex differences; suicide attempt; late life; depression; physical disability

Online: 11 December 2017 (13:04:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1410.v1

The Outcome of the Psychological and Therapeutical Care of Hospitalized COVID-19 Patients: National African Pilot Study

Yassine BENHADDOUCH, Nour ELhouda Fares, Soumaya BENMAAMAR, Youssef OUAZZANI HOUSNI TOUHAMI, Amine BOUT, Chadya AARAB, Said BOUJRAF, Rachid AALOUANE

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Anxiety; depression; post-traumatic stress; hydroxychloroquine; family support; intensive care

Online: 25 March 2024 (08:08:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0521.v1

Identifying factors affecting burnout syndrome and depression among dentists working in different institutions

Levent CİĞERİM, Zeynep Dilan ORHAN, İbrahim DOĞRU, Nazlı Hilal KAHRAMAN, Abdalrahim HUSSEİN, Hayrettin BAŞ

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: burnout; depression; dentist; emotional exhaustion; faculty; ODHC; private clinic; dentistry

Online: 8 February 2024 (11:57:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0108.v1

Early Improvement of Affective, Fatigue and Allodynic Symptoms in a Cohort of Resistant Migraineurs Treated with Anti-CGRP/R Antibodies

Alessandra Della Vecchia, Ciro De Luca, Lucrezia Becattini, Letizia Curto, Elena Ferrari, Gabriele Siciliano, Sara Gori, Filippo Baldacci

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: migraine; depression; anxiety; fatigue; comorbidities; monoclonal antibodies anti-CGRP/R

Online: 2 February 2024 (04:54:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0030.v1

Biological Peripartum Predictors of Postpartum Depression: Protocol for Systematic Review and Meta-Analysis

Marwa Alhaj Ahmad, Shamsa Al Awar, Gehan Sayed Sallma, Meera Alkaabi, Darya Smetanina, Yauhen Statsenko, Kornelia Zareba

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: postpartum; depression postpartum; blues postpartum; psychosis review article; risk factors

Online: 1 February 2024 (12:48:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1587.v1

Self-Esteem and Occupational Factors as Predictors of the Incidence of Anxiety and Depression among Health Workers during the COVID-19 Pandemics in Latvia

Laura Valaine, Māra Grēve, Maksims Zolovs, Gunta Ancāne, Artūrs Utināns, Ģirts Briģis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: self-esteem; occupational factors; depression; anxiety; healthcare workers; Covid-19

Online: 26 November 2023 (06:21:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0490.v1

Geochemical Characteristics and Environmental Implications of the Paleocene-Eocene in the Jiangling Depression, Southwestern Jianghan Basin

Kai Yan, Chunlian Wang, Renyi Chen, Jiuyi Wang, Ruiqin Li, Lihong Liu

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: Jiangling depression; Paleocene-Eocene saline lake; climate; redox conditions; salinity

Online: 8 November 2023 (08:39:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1111.v2

Major Recurrent Depression in Middle-Aged Adults: Symptoms and Life Themes in a Latent Semantic Indexing Approach

Alin Gilbert Sumedrea, Cristian Mihai Sumedrea, Irina Minescu

Subject: Social Sciences, Psychology Keywords: cosine similarity; cosine disimilarity; life themes; major recurrent depression; symptoms

Online: 20 October 2023 (03:13:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0167.v1

Impact of Robotic Assisted Gait Therapy on Depression and Anxiety Symptoms in Subacute Spinal Cord Injury (SCI)—A Prospective Clinical Study

Alicja Maria Widuch-Spodyniuk, Beata Tarnacka, Bogumił Korczyński, Justyna Zofia Wiśniowska

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: spinal cord injury; robotic rehabilitation; coordinative rehabilitation; depression; mood; anxiety

Online: 5 September 2023 (04:18:22 CEST)

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Background: Mood disorders, especially depression, and emotional difficulties such as anxiety are very common problems among patients with spinal cord injury (SCI). The loss of physical training may deteriorate their mental state, which in turn has a significant impact on the improvement of functioning. The aim of the present study was to examine the influence of innovative rehabilitation approaches involving robotic assisted gait therapy (RAGT) on mood and anxiety symptoms in pa-tients with SCI. Methods: To this single-centre, single-blinded, single-arm, prospective study, 110 participants with subacute SCI were enrolled; patients were divided into experimental (robotic assisted gait therapy -RAGT) and control (conventional gait therapy with dynamic parapodium - DPT) groups. They received five training sessions per week over 7- weeks. The severity of de-pression was assessed by Depression Assessment Questionnaire (KPD) and anxiety symptoms by State - Trait Anxiety Inventory (STAI X-1) on the beginning and end of therapy. Results: SCI patients experienced significantly lower levels of anxiety and depression-related symptoms after completing the seven-week rehabilitation program (KPD: Z=6.35; p<0.001; r=0.43; STAI X-1: Z=-6.20; p<0.001; r=0.42) in both group of patients. In the RAGT group, post-rehabilitation measurements also indicated an improvement in psychological functioning, i.e., a decrease in depression and anxiety, and an increase in self-regulation. Significant results were noted for each variable (STAI X-1: Z = -4.93; KPD: Z = -5.26; SR: Z = -3.21). In the control group, there was also a decrease in the effect on the depression, anxiety-state and an increase in self-regulation ability (STAI X-1: Z=-4.01; KPD: Z=-3.65; SR: Z=-2.83). Rehabilitation modality did not appear to have a statistically significant relationship with the magnitude of improvement in KPD (including SR) and STAI scores. However, there were some significant differences when comparing the groups by extent and depth of injury and type of paralysis. The study also did not find a significant rela-tionship between improvements in physical aspects and changes in psychological factors. Conclusion: Subjects in RAGD and DPT groups experienced a decrease in anxiety and depres-sion after a 7-week rehabilitation program. However, the rehabilitation modality (DPT vs. RAGT) did not differentiate patients with SCI in terms of the magnitude of this change. Our results may suggest that individuals with severe neurological condition and complete spinal cord injury (AIS A) may experience more benefit in terms of change in psychological parameters after rehabilitation with RAGT.

Preprint ARTICLE | doi:10.20944/preprints202308.1808.v1

Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of Depression

Chorpeth Chalermwongkul, Charinya Khamphukdee, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Juthamart Maneenet, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Oroxylum indicum, baicalein, unpredictable chronic mild stress, HPA-axis, depression

Online: 28 August 2023 (03:35:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0435.v1

Psychological Impacts of COVID-19 and Its Associated Factors Among People Living in Abha City, Saudi Arabia

Ebtehal Jaber Asiri, Adam Dawria, Bayapa Reddy Narapureddy, Lingala Kalyan Viswanath Reddy, Yousef Zahrani, Bharat Kumar Mamilla Mugaiahgari, Ali Mohieldin, Mohammad Suhail Khan, Khursheed Muzammil, Abdelrhman Ahmed Galaleldin Altijani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; Mental Health problems; DASS-21 scale; Depression; Anxiety

Online: 6 June 2023 (09:59:06 CEST)

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Background: The novel coronavirus (COVID-19) infection is primarily transmitted through respiratory droplets from an infected person and contact with tainted surfaces or items. Social distancing became the primary measure of preventing the spread of COVID-19, with the principal aim being to reduce the probability of contact with an already infected person. Social distancing can be distressing, as it is against the community's way of life. Saudi Arabia imposed a curfew and suspended all religious, entertainment, sporting, and mass congregations. The daily updates on COVID-19 infection and mortality are upsetting and further, aggravate depression and anxiety. With this background, this study was planned with the following objectives. To determine the sociodemographic profile of the study participants, to find the prevalence of psychological morbidity, and to measure the association between the sociodemographic details, COVID-19 associated factors, and psychological effects among Abha citizens during the COVID-19 pandemic. Methodology: A descriptive cross-sectional community-based study was conducted in the Abha city population from August 2021 to July 22. This study followed snowball sampling, the data was collected using an online Google form the link was shared in WhatsApp groups and through emails to contacts, asking friends to share it with their friends, until reaching the adequate sample size the responses were accepted. Results: A total of 530 participated, and their age ranged from 19 -70 years. Many of the participants (34.5%, n=183) belonged to 36-45 years old. Most of the responders were 69.8% married and Females (69.2%, n=367). Half of the participants had been quarantined (49.6%), and 51.5% were scared from fear of COVID-19. 64.8% of the participants had depression; 14.2%, 20.8%, 13.6%, and 16.2% had mild, moderate, severe, and extremely severe depression, respectively. Around 58.2% of participants suffered from anxiety; 5.8% experienced mild anxiety, 21.7% moderate anxiety, and 30.7% severe anxiety. The proportion of stress among the participants was 45.0%; 10.8% had mild stress, 9.4% had moderate stress, and 24.5% had severe to extremely severe stress. Conclusions: COVID-19 poses mental health problems among individuals and communities. There is a need to find the more susceptible individuals for mental health issues or other psychological disorders. Mental health and psychological problems can be resolved with health education, counseling, and appropriate interventions to curb the negative health impacts of COVID-19.

Preprint ARTICLE | doi:10.20944/preprints202305.1941.v1

Coping as a Mediator between Attachment and Depression either in Pregnancy or in the Early Postpartum Period: A Structural Equation Modelling Approach

Mario Altamura, Ivana Leccisotti, Laura De Masi, Fiammetta Gallone, Livia Ficarella, Melania Severo, Simona Biancofiore, Antonio Ventriglio, Annamaria Petito, Giuseppe Maruotti, Luigi Nappi, Antonello Bellomo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Perinatal Depression; Attachment Style; Coping Strategies; Gender Medicine; Women Health

Online: 26 May 2023 (14:42:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0018.v1

Postpartum depression and Health: Role of Perceived Social Support among Women.

Samrah Jamshaid, Najma Iqbal Malik, Irfan Ullah, Sundas Saboor, Fauzia Arain, Domenico De Berardis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Insomnia; Mental health; Physical health; perceived social support; Postpartum Depression

Online: 3 January 2023 (08:30:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0027.v1

Association of Self-Reported Depression Symptoms with Physical Activity Levels in Czechia

Geraldo A. Maranhao Neto, Eduardo Lattari, Bruno Ribeiro Ramalho Oliveira, Anna Polcrova, Maria Infante-Garcia, Sarka Kunzova, Gorazd B Stokin, Juan P. Gonzalez-Rivas

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Mental Health; Depression; Physical Activity; Population Health; Adult; Middle Aged

Online: 1 September 2022 (16:13:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0141.v1

Parental Self-Compassion and Child Adjustment: The Mediating Role of Parental Depressive Symptoms

Rebecca Y. M. Cheung, Zechen Li, Audrey Pui Lam Ho

Subject: Social Sciences, Psychology Keywords: externalizing problems; internalizing problems; parental depression; prosocial behavior; self-compassion

Online: 15 April 2022 (09:11:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0267.v1

A single-case design investigation for measuring the efficacy of Gestalt therapy to treat depression in older adults with dementia in Italy and in Mexico: a research protocol

Alessandra Merizzi, Rosanna Biasi, José Fernando Álvarez Zamudio, Margherita Spagnuolo Lobb, Sara Santini

Subject: Social Sciences, Psychology Keywords: Gestalt therapy; dementia; depression; single-case experimental design; psychosocial interventions

Online: 19 January 2022 (09:32:12 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0028.v2

Depression Diagnosis by Deep Learning Using EEG Signals: A Systematic Review

Atefeh Safayari, Hamidreza Bolhasani

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Deep Learning; Depression; Electroencephalogram; EEG; Depressive Disorders; Systematic Literature Review

Online: 10 November 2021 (15:29:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0362.v1

Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

Hawraa Al-Jassas, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; depression; chronic fatigue syndrome; inflammation; neuro-immune; psychiatry

Online: 14 June 2021 (13:01:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0758.v1

Neuropsychological Sequelae in Attention and Memory in Women Victims of Gender-Based Violence and Their Implication in Depression. A Multivariate Analysis

Ana Victoria Torres García, Miguel Pérez-Fernández, Maria Concepción Vega Hernández, Concha Anón Rubio

Subject: Business, Economics And Management, Accounting And Taxation Keywords: abused women; neuropsychological sequelae; attention; memory; depression; Luria DNA battery

Online: 28 April 2021 (15:47:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0669.v1

Adverse Childhood Experiences Combined with Emotional and Physical Abuse by the Partner Predict Antenatal Depression.

Yoshiko Abe, Wandee Sirichokchatchawan, Ussanee Sangkomkamhang, Sirina Satthapisit, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Antenatal depression; Adverse childhood experiences; intimate partner violence; social support

Online: 26 March 2021 (14:18:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0631.v1

Proposed Model and Approach to Graduate Mentorship and Supervision During COVID-19

Carol Nash

Subject: Social Sciences, Education Keywords: COVID-19; graduate students; anxiety; depression; mentorship; supervision; narrative research

Online: 29 January 2021 (15:20:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0623.v1

The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups

Michael Maes, Marta Kubera, Kristina Stoyanova, Jean–Claude Leunis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; neuroimmune; inflammation; oxidative and nitrosative stress; autoimmune; bacterial translocation

Online: 29 January 2021 (13:17:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0742.v1

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

Nakul Ravi Raval, Annette Johansen, Lene Lundgaard Donovan, Nídia Fernandez Ros, Brice Ozenne, Hanne Demant Hansen, Gitte Moos Knudsen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Psilocybin; psychedelics; neuroplasticity; SV2A; 5-HT2A; depression; autoradiography; functional-selectivity

Online: 30 November 2020 (16:30:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0075.v2

Machine Learning Approaches for Accurate Prediction of Relative Humidity based on Temperature and Wet-Bulb Depression

Mahdi Ghadiri, Azam Marjani, Samira Mohammadinia, Manouchehr Shokri

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: wet-bulb depression; relative humidity; ANFIS; artificial neural network; LSSVM

Online: 2 November 2020 (09:44:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0202.v1

Construction of an Exposure-Pathway-Phenotype in Children with Depression due to Transfusion-Dependent Thalassemia: Results of (Un)supervised Machine Learning

Hussein Al-Hakeim, Asawer Najm, Shatha Moustafa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: transfusion-dependent thalassemia; depression; neuro-immune; inflammation; biomarkers; oxidative stress

Online: 16 June 2020 (08:51:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0292.v1

Lowered Paraoxonase 1 Activities May Explain the Comorbidities Between Temporal Lobe Epilepsy or Mesial Temporal Sclerosis and Comorbid Depression, Anxiety and Psychosis

Ana Paula Michelin, Mchael Maes, Thitiporn Supasitthumrong, Chusak Limotai, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania Gastaldello Moreira, Buranee Kanchanatwan, Décio Sabbatini Barbosa

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: temporal lobe epilepsy; antioxidants; oxidative stress; neuroimmune; major depression; schizophrenia

Online: 19 March 2020 (02:11:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0175.v1

Lowered Serum Cesium Levels in Schizophrenia: Association with Immune-Inflammatory Biomarkers and Cognitive Impairments

Abbas F. Almulla, Shatha Rouf Moustafa, Arafat Hussein Al-Dujaili, Hussein Kadhem Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; neuroimmunomodulation; major depression; chronic fatigue syndrome; myalgic encephalomyelitis; biomarkers

Online: 14 February 2020 (01:53:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0077.v1

The Role of Immune and Oxidative Pathways in Menstrual-Cycle Associated Depressive, Physio-Somatic, Breast and Anxiety Symptoms: Modulation by Sex Hormones

Chutima Roomruangwong, Andressa Keiko Matsumoto, Ana Paula Michelin, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Sunee Sirivichayakul, Andre Carvalho, Decio S. Barbosa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual syndrome; depression; anxiety; antioxidants; neuro-immune; inflammation; oxidative stress

Online: 9 January 2020 (08:17:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0317.v1

Childhood Trauma and Stressful Life Events Are Independently Associated with Sleep Disturbances in Adolescents

Suman K.R. Baddam, Rene L. Olvera, Craig A. Canapari, Michael J. Crowley, Douglas E. Williamson

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: childhood trauma; stressful life events; sleep patterns; anxiety; depression; adolescence

Online: 27 May 2019 (12:36:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0092.v1

Development of a Novel Staging Model for Affective Disorders Using Partial Least Squares Bootstrapping: Effects of Lipid-Associated Antioxidant Defenses and Neuro-Oxidative Stress

Michael Maes, Juliana Brum Moraes , Ana Congio , Kamila Landucci Bonifacio , Decio Sabbatini Barbosa , Heber Odebrecht Vargas , Ana Paula Michelin , Andre F. Carvalho , Sandra Odebrecht Vargas Nunes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: staging, affective disorders, major depression, bipolar disorder, oxidative, neuro-immune

Online: 7 December 2018 (13:56:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0105.v1

Mediation and Moderation Analysis of the Relationship between Total Protein Concentration and the Risk of Depressive Disorders in Older Adults with Function Dependence in Home Care

Grzegorz Józef Nowicki, Barbara Ślusarska, Agnieszka Bartoszek, Katarzyna Kocka, Alina Deluga, Hanna Kachaniuk, Marta Łuczyk

Subject: Public Health And Healthcare, Nursing Keywords: depression; total protein; elder people; physical function; long-term care

Online: 6 August 2018 (09:41:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0451.v2

Short but Continuous Natural Pain during Meditation Sittings for Depression Treatment: A Case Report

Mingwei Huang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: pain; depression; treatment; meditation; synaptic plasticity and homeostasis; nerve stimulation

Online: 31 May 2018 (09:56:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0762.v1

Mood Disorders and Sleep Quality among Undergraduate Students during Covid-19

Mariam Gogichadze, Nnaemeka Emmanuel Mgbedo, Irvin Savio Joao, Chinyere Victory Chukwu, Roshan Afreen Mohammad, Inga Odzelashvili, Natia Landia

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Depression; Anxiety; Stress; Sleep quality; Students; Covid19

Online: 14 February 2024 (08:18:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0233.v1

Behind the Sadness of Teen Girls: A Retrospective Survey Analysis

Onur Baser, Sara Alsaleh, Yixuan Zeng, Isabel Baser

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: depression; adolescent girls; National Survey on Drug Use and Health; pandemic

Online: 5 February 2024 (07:56:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1487.v1

Examining The Association of Violence at Multiple Ecological Levels and Child Mental Health Outcomes in Iraq: Mapping Where Are the Most Vulnerable.

Ruaa Al Juboori

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: child abuse; violence; domestic violence; corporal punishment; depression; anxiety; spatial; Iraq

Online: 20 December 2023 (09:44:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0288.v1

The relationship between Depression, Anxiety, Chronic Pain and Pain Pressure Threshold of the Masseter Muscle Healthy Young Subjects: A Pilot Study

Weronika Anna Kruk-Majtyka, Tomasz Marciniak

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: algometry; facial pain; temporomandibular disorders; muscle tenderness; depression; anxiety; masseter muscle

Online: 5 December 2023 (20:34:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1320.v1

Diagenesis of the Permian Fengcheng Formation Shale Series in the Mahu Sag, Junggar Basin, China

Bin Bai, Jiwei Liang, Chaocheng Dai, Wenjun He, Zhenkun Yu, Ying Bai, Xiaobin Chang, Meng Zheng, Hanlin Li, Hao Zong

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: alkaline diagenesis; shale series; Fengcheng Formation; Mahu Depression; Junggar Basin; China

Online: 20 October 2023 (08:33:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1850.v1

Deepening Depression in Women Balancing Work-Life and Caregiving during the COVID-19 Pandemic: Findings of Gender-Specific Face-to-Face Street Interviews Conducted in Italy

Laura Giusti, Silvia Mammarella, Sasha Del Vecchio, Anna Salza, Massimo Casacchia, Rita Roncone

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Women; depression; family burden; family functioning; pandemic COVID-19; collective traumas

Online: 27 September 2023 (08:33:42 CEST)

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Purpose: This study investigated the impact of the COVID-19 pandemic on mental health, quality of life, and family functioning in a sample of the general female population, exploring difficulties encountered in managing family and work responsibilities and burden of care when taking care of a loved one. The study was moreover aimed at investigating factors capable of influencing severe depressive symptomatology in the context of socio-demographics, traumatic events, individual vulnerability, and family functioning. Method: During a weekend devoted to Mental Health initiatives (October 8-10, 2021), 211 women were interviewed (47% exposed to the 2009 L’Aquila earthquake). Results: More than 50% of the sample reported a higher complexity in managing their lives during the COVID-19 pandemic compared to their previous routine, with no statistically significant differences between working women and non-workers, although the latter obtained higher scores for depressive symptomatology and poorer quality of life. Compared to non-caregivers, women caregivers (22.3%) in charge of the care of loved ones affected by physical (10.9%) or psychiatric disabilities (11.4%) complained of a poorer quality of life, with those caring for people affected by mental disorders seeming to experience a more significant worsening. Approximately 20% of the total sample reported severe depressive symptomatology. Previous access to mental health services (O.R. 10.923), low level of education (O.R. 5.410) and difficulties in management of their everyday lives during the COVID-19 pandemic (O.R. 3.598) were found to be the main variables predictive of severe depressive psychopathology. Old age, good problem-solving skills and ability to pursue personal goals were identified as protective factors. Conclusions: The COVID-19 pandemic underlined the need for support for emotionally vulnerable women with pre-existing mental health conditions, partly reflecting the cumulative effects of traumas.

Preprint ARTICLE | doi:10.20944/preprints202309.0441.v1

Effects of Language Brokering on Psychological Well-Being. A Study on Latino Children in Italy

Giovanni Giulio Valtolina, Maria Luisa Gennari, Giancarlo Tamanza

Subject: Social Sciences, Psychology Keywords: language brokering; mental health; anxiety; depression; psychological well-being; Latino children

Online: 7 September 2023 (03:34:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0469.v1

Mental Health Outcomes and Vulnerability to COVID-19: A Systematic Review

Ncebakazi Dondashe, Godfred Anakpo, Syden Mishi

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; mental health outcomes; pandemic; vulnerable population; depression; health workers

Online: 7 August 2023 (10:39:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1945.v1

Cognitive Profile of SARS-cov-2 Recovered Patients: A Comprehensive Analysis of Persistent Dysfunctions in Long COVID

Alisson Rafael Oliveira Lima, Beatriz Cavendish, Bianca Silva Pinto, Rebeca Pelosof, Juliana Pereira de Sousa, Pedro Henrique Rodrigues da Silva, Laiss Bertola, Mariana Pita Batista, Adriano Augusto Domingos Neto, Andre Russowsky Brunoni, Kallene Summer Moreira Vidal, Dora Fix Ventura

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: memory loss; long COVID; post COVID; depression; mental confusion; COVID-19

Online: 27 July 2023 (13:28:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1109.v1

Factors Associated with Depression in Infertile Couples: A Study in Thailand

Tong Yang, Nahathai Wongpakaran, Tinakon Wongpakaran, Ubol Saeng-Anan, Charuk Singhapreecha, Rewadee Jenraumjit, Carmelle Peisah

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: actor-partner interdependence model; depression; couple; dyadic analysis; infertility; mental health

Online: 16 May 2023 (05:45:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0447.v1

Investigating Sedentariness and Health Status of Primary School Teachers in Cape Coast Metropolis, Ghana

Edward Wilson Ansah, Mawuli Adabla, Jerry Norgbedzie, Eric A Aloko, John Elvis Hagan Jr.

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Anxiety; depression; discomfort; pain; physical inactivity; sedentariness; self-rated health status

Online: 27 March 2023 (05:15:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0227.v1

Differences in the Course of depression and anxiety After COVID-19 Infection Between Recovered Patients With and Without a Psychiatric History: A Cross-Sectional Study

Megumi Hazumi, Kentaro Usuda, Emi Okazaki, Mayumi Kataoka, Daisuke Nishi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; depression; anxiety; post-acute COVID-19 syndrome; post-COVID

Online: 12 August 2022 (04:56:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0455.v1

Depression, Anxiety, and Chronic Fatigue Symptoms in Acute Rheumatoid Arthritis are Associated with Immune-inflammatory, Autoimmune, Endogenous Opioid System and Lactosylceramide Signaling Pathways: A Nomothetic Network Approach

Hasan Smesam, Hasan Qazmooz, Sinan Khayoon, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: inflammation; neuro-immune; cytokines; major depression; chronic fatigue syndrome; affective disorders

Online: 27 September 2021 (16:30:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0106.v1

Physical Activity, Mental Health and Wellbeing During the first COVID-19 Containment in New Zealand: A Cross-sectional Study

Wendy J O’Brien, Claire E Badenhorst, Nick Draper, Arindam Basu, Catherine A Elliot, Michael J Hamlin, John Batten, Danielle Lambrick, James Faulkner

Subject: Social Sciences, Psychology Keywords: Coronavirus; pandemic; exercise; depression; anxiety; wellness; physical distancing; lifestyle behavior change

Online: 5 July 2021 (15:27:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0604.v1

Evaluating the Prevalence of Psychological Outcomes in Chinese Healthcare Workers During the COVID-19 Pandemic

Ryan Sadjadi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; Mental Health; Prevalence; Depression; Anxiety; Insomnia; Stress; PTSD; Distress

Online: 25 May 2021 (10:29:20 CEST)

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Working Paper ARTICLE

Depression in Bolivian Adults During COVID 19 Social Confinement: Moderating Effects of Resilience and Self-Efficacy

Eric Roth, Gustavo Choque, M. Fernanda García, Andrés Villalobos

Subject: Social Sciences, Psychology Keywords: Depression by confinement; COVID 19; Bolivia; perceived loneliness; anxiety; moderation effects

Online: 2 April 2021 (18:47:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0632.v1

Leukocyte Telomere Length Is Not Shortened in Methamphetamine Dependence or Methamphetamine-Induced Psychosis but Is Increased Following Traumatic Events.

Teerayuth Rungnirundorn Teerayuth Rungnirundorn, Kuakarun Krusong, Rasmon Kalayasiri, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: methamphetamine; psychosis; schizophrenia; withdrawal; depression; neuro-immune; oxidative stress; telomere length

Online: 25 March 2021 (15:13:56 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0368.v1

Association between Fruit and Vegetable Consumption and Depression Symptoms in Young People and Adults Aged 15-45: A Systematic Review of Cohort Studies

Putu Novi Arfirsta Dharmayani, Melissa Juergens, Margaret Allman Farinelli, Seema Mihrshahi

Subject: Social Sciences, Psychology Keywords: fruit; vegetables; depressive symptoms; depression; young people; young adult; nutrition; diet

Online: 15 December 2020 (10:18:23 CET)

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Higher consumption of fruit and vegetables has been associated with a lower risk of various chronic diseases including coronary heart disease, obesity, and certain cancers. Recently, fruit and vegetable intake has also been linked with mental health, including depression. This systematic review aimed to evaluate the association between fruit and vegetable intake and depressive symptoms in young people and adults aged 15-45. The systematic review focused on peer-reviewed cohort studies published from 1 January 2000 to 31 August 2020 using searches of six electronic databases. The exposure was fruit and vegetable consumption analysed both separately and/or together, and the outcome was depression or depressive symptoms. Data from eligible studies were extracted according to predefined criteria and the studies were appraised using the Newcastle-Ottawa Scale (NOS) for Cohort Studies to evaluate for study quality and risk of bias. To evaluate the association between fruit and vegetable consumption and depressive symptoms, a narrative synthesis was conducted. Of 9667 potentially relevant studies that were screened for title and abstracts, 144 full text studies were evaluated, and 12 studies from seven countries were deemed eligible and included in the qualitative synthesis. Using the NOS framework one study was categorised as ‘very good’ quality, ten studies were ‘good’ quality, and two studies were ‘moderate’ quality. With respect to combined fruit and vegetable consumption, two studies demonstrated an inverse association with depression. When the effects of fruit and vegetable on depression were analysed separately, five studies showed significant associations in fruit consumption, and two studies showed significant associations in vegetable consumption. Four studies showed no association between combined fruit and vegetable consumption and depression, one study showed no association between fruit consumption and depression, and two studies showed no association between vegetable consumption and depression. Despite some contradictory results in the studies included in this review, the evidence seems to be building that a possible association exists, and this may have implications for addressing the burden of mental illness in young people and adults aged 15-45 years. Well-designed prospective cohort studies are needed to provide more robust evidence on the diet-depression relationship.

Preprint ARTICLE | doi:10.20944/preprints202012.0080.v1

Multivariate Analysis of Structural and Functional Neuroimaging Can Inform Psychiatric Differential Diagnosis

Drozdstoy Stoyanov, Sevdalina Kandilarova, Katrin Aryutova, Rositsa Paunova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: multivariate linear method; validation; diagnosis; discriminative; signatures of disease; schizophrenia; depression

Online: 3 December 2020 (10:38:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0422.v1

Mental Health Status of University Healthcare Workers During the COVID-19 Pandemic: A Post-Movement Lockdown Assessment

Luke Sy-Cherng Woon, Hatta Sidi, Nik Ruzyanei Nik Jaafar, Mohammad Farris Iman Leong Bin Abdullah

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Depression; anxiety; stress; university healthcare workers; COVID-19; post–movement lockdown

Online: 16 November 2020 (13:46:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0536.v1

Depression, Loneliness, Activities of Daily Living, Social Support, and Life Satisfaction in Older Adults at High-Risk for Dementia

Sunghee Kim, Heesook Son, Kwisoon Choe, Kyoungsook Lee

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dementia; depression; loneliness; activities of daily living; social support; life satisfaction

Online: 27 October 2020 (07:55:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0149.v1

The Relationships between Smartphone Addiction of Middle School Students and Smartphone Usage Types, Depression, ADHD, Stress, Interpersonal Problems, and Parenting Attitude

Youl Pyo Hong, Yeon Ok Yeom, Myung Ho Lim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Smartphone Addiction; Middle School Students; Smartphone Usage Types; Depression; Parenting Attitude

Online: 6 September 2020 (16:27:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0053.v1

A Nomothetic Network Model Disclosing the Comorbidity of Depression and Unstable Angina: Effects of Atherogenicity, Insulin Resistance, Immune Activation, Antioxidants, the Endogenous Opioid System, Trace Elements, and Macrominerals

Rana Mousa, Hasan Smesam, Hasan Qazmooz, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: unstable angina, inflammation, neuro-immune, major depression, oxidative stress, antioxidants, atherogenicity

Online: 3 September 2020 (04:40:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0258.v1

Increased Nitro-Oxidative Stress Toxicity as a Major Determinant of Increased Blood Pressure in Mood Disorders

Kamila Landucci Bonifacio, Décio Sabbatini Barbosa, Estefânia Gastaldello Moreira, Carine Farias Coneglian, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Juliana Brum Moraes, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; oxidative and nitrosative stress; antioxidants; inflammation; neuro-immune; biomarkers

Online: 15 May 2020 (16:52:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0045.v1

Health Locus of Control in Parents of Children with Leukemia and Associations with Their Life Perceptions and Depression Symptomatology

Marta Tremolada, Livia Taverna, Sabrina Bonichini, Maria Caterina Putti, Marta Pillon, Alessandra Biffi

Subject: Social Sciences, Psychology Keywords: children with leukemia; parents; health locus of control; depression; life perceptions

Online: 4 March 2020 (04:32:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0272.v1

Application of Wearables to Improve Uptake of Exercise Therapy during Hemodialysis Treatment for Reducing Depression Symptom – A Single Blinded Randomized Controlled Trial

He Zhou, Fadwa Al-Ali, Gu Kang, Abdullah Hamad, Rania Ibrahim, Tala Talal, Bijan Najafi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Exergame; depression; hemodialysis; end-stage renal disease; wearable technology; digital health

Online: 23 January 2020 (16:29:53 CET)

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Working Paper ARTICLE

Effect of a Comprehensive Health Care Program on Blood Pressure, Blood Glucose, Body Composition, and Depression in Older Adults Living Alone: A Quasi-experimental Pre-posttest Study

Eun Jeong Hwang, In Ok Sim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: older adults; blood pressure; blood glucose,; depression,; senior center; comprehensive healthcare

Online: 5 December 2019 (11:48:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0048.v1

Clinical Risk Factors that Predict Functional Recovery in Ischemic Stroke Patients with Pre-Stroke Depression

Leah Wormack, Brice Blum, Benjamin Bailes, Thomas Nathaniel

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Ambulation, Ischemic stroke, pre-stroke depression, recombinant tissue plasminogen activator (rtPA)

Online: 6 June 2019 (10:37:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0105.v1

Upregulation of the Nitrosylome in Bipolar Disorder Type 1 (BP1), but not BP2, and Major Depression: Increased IgM Antibodies to Nitrosylated Conjugates are Associated with Indicants of Leaky Gut

Michael Maes, Denitsa Simeonova, Drozdstoy Stoyanov, Jean–Claude Leunis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression, bipolar disorder, oxidative and nitrosative stress, neuro-immune, inflammation, cytokines

Online: 8 March 2019 (09:13:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0260.v1

Interpolation of Small Datasets in the Sandstone Hydrocarbon Reservoirs, Case Study from the Sava Depression, Croatia

Tomislav Malvić, Josip Ivšinović, Josipa Velić, Rajna Rajić

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: interpolation; permeability; injected water; inverse distance weighting; sava depression; miocene; Croatia

Online: 28 February 2019 (06:54:38 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0732.v1

Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction

Vincent Avecilla, Andrea Avecilla

Subject: Social Sciences, Behavior Sciences Keywords: depression; estrogenic endocrine disruptor; environmental factor; inhibitor of differentiation; mental disorder

Online: 31 October 2018 (04:51:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0411.v2

Short but Continuous Natural Pain for Depression Treatment and Beyond

Mingwei Huang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: pain; depression; treatment; meditation; synaptic plasticity and homeostasis; DNA damage response

Online: 31 May 2018 (09:51:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0176.v1

Psychometric Evaluation of the Depression Anxiety Stress Scale 8-items (DASS-8)/DASS-12/DASS-21 among Italian and Swiss Family Caregivers of Patients with Dementia

Amira Ali, Rana Ali Alameri, Amin Omar Hendawy, Rasmieh Al-Amer, Ghada Shahrour, Esraa M. Ali, Abdulmajeed A. Alkhamees, Nashwa Ibrahim, Bothaina Hussein Hassan

Subject: Social Sciences, Psychology Keywords: psychological distress/anxiety/depression; dementia; Alzheimer’s disease; Parkinson’s disease; short form of the Depression Anxiety Stress Scale 21; Depression Anxiety Stress Scale 8-items; factor structure; psychometric properties; structural validity; validation; measurement invariance; old age/elders/elderly; informal; family caregivers; spouse; adult children

Online: 9 August 2022 (08:44:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1424.v1

Social Inhibition and Depressive symptoms among Couples Having Children with Autism Spectrum Disorder: The Mediating Role of Perceived Family Support

Ting Pan, Tinakon Wongpakaran, Nahathai Wongpakaran, Bijing He, Danny Wedding

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: social inhibition; autism; depression; family support; parents; actor partner interdependence mediation model

Online: 26 February 2024 (10:26:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1244.v1

A Place for Women and Women's Issues: An Examination of Narratives on Postpartum Depression Self-Disclosure on Pinterest

Annika Fenton, Aleksandra Erak, Anne TM Konkle

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: self-disclosure, postpartum depression, netnography, Pinterest, perinatal mental health, and women’s health

Online: 18 December 2023 (09:10:29 CET)

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This study aimed to expand and inform the growing body of research on Postpartum Depression, from a netnographic standpoint, for the social media platform of Pinterest. More specifically, it aimed to assess the type of content present on Pinterest regarding Postpartum Depression shared by women in 2018 and 2021, as well as examine the subjective experience of women who have experienced this mood disorder. Data were collected following a search using the keywords “Postpartum Depression” on Pinterest on two separate timestamps (2018 and 2021); pins were limited to those in English or French. Master themes were identified among all pins and those identified as “self-disclosure” were subsequently further analyzed. Self-disclosure data were separately analysed using thematic analysis, specifically adopting a deductive thematic approach for the 2021 data set stemming from the coding scheme created from analysis of the 2018 data. Major themes were identified, and an analysis of frequency was performed for each sub-theme, along with qualitative examples associated with each theme. A total of 483 Pinterest pins from two different time points of 2018 (169 pins) and 2021 (314 sample pins) were analyzed. Five primary categories were identified in both 2018 and 2021, with five additional categories being identified in the 2021 dataset. Comparative results from 2018 and 2021 self-disclosure pins show individuals’ varying yet similar subjective manifestations of PPD, the potential need to adopt a multidisciplinary treatment approach, and the societal fears, such as mental health stigma, that are playing a part in help-seeking behavior hesitancies. Our findings provide imperative insight into individuals’ subjective experiences with PPD; experiences that involve a sensitive and vulnerable topic. Netnographic research, along with Pinterest, must be taken into consideration for future work delving into women’s health issues, including those surrounding perinatal mental health.

Preprint ARTICLE | doi:10.20944/preprints202311.0550.v1

Social-Cognitive Determinants of Patients’ Hand Hygiene Decisions and the Role of Mental Health: Application of the Health Action Process Approach

Franziska Maria Keller, Alina Dahmen, Lukas Kötting, Christina Derksen, Sonia Lippke

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Hand hygiene; compliance; health action process approach; mental health; depression; generalized anxiety

Online: 8 November 2023 (11:21:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.1146.v2

Depression and Its Associated Factors Among Undergraduate Engineering Students: A Cross-Sectional Survey in Thailand

Yuanyue Huang, Tinakon Wongpakaran, Nahathai Wongpakaran, Patraporn Bhatarasakoon, Preda Pichayapan, Shirley Worland

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Depression; engineering undergraduates; romantic relationship; self-esteem; interpersonal difficulty; social skill; neuroticism

Online: 25 July 2023 (13:24:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1904.v1

Patient-Oriented Research to Improve Internet-delivered Cognitive Behavioural Therapy for People of Diverse Ethnocultural Groups in Routine Practice

Ram P. Sapkota, Emma Valli, Andrew Wilhelms, Kelly Adlam, Lee Bourgeault, Vanessa Heron, Kathryn Dickerson, Marcie Nugent, Heather D. Hadjistavropoulos

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: internet-delivered therapy; depression; anxiety; cultural adaptation; patient-oriented research; digital health

Online: 26 May 2023 (09:46:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0313.v1

Enhancing Resilience Regarding Depression, Anxiety and COVID-19 with a Narrative Method of Ordering Memory Effective in Researchers Experiencing Burnout

Carol Nash

Subject: Social Sciences, Behavior Sciences Keywords: resilience; depression; anxiety; COVID-19; amygdala; hippocampus; burnout; researchers; narrative; ordering memory

Online: 23 March 2022 (08:51:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0123.v1

A Short Oro-Gastric Imipramine Administration in Brucella abortus 2308 Infected Mice Decreases CFU Count at the Spleen; Improves the IFN-γ/IL-6 Ratio; Restores Serotonin Levels in the Hippocampus, Muscular Strength, and Mood

Jesús Octavio Maldonado-Tapia, José Luis Maldoando-García, Gilberto Pérez-Sánchez, Enrique Becerril-Villanueva, Samantha Alvarez-Herrera, Lenin Pavón, Gabriel Gutiérrez-Ospina, Rubén López-Santiago, Martha C Moreno-Lafont

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Depression; psychoimmune resilience; tricyclic antidepressants; serotonin; modulation of inflammatory response; infectious diseases

Online: 8 March 2022 (11:04:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0423.v1

Sensory-processing Sensitivity and Pathways to Depression and Aggression: The Mediating Role of Trait Emotional Intelligence and Decision-making Style. A Pilot Study.

Nikola Drndarevic, Sonja Protic, Jose M Mestre

Subject: Social Sciences, Psychology Keywords: sensory-processing sensitivity; depression; agression; emotional intelligence; decision-making style; gender differences

Online: 23 November 2021 (14:07:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0509.v1

Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17, Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due to Type 2 Diabetes Mellitus: A Nomothetic Network Approach

Hussein Al-Hakeim, Hadi Hadi, Ghoufran Jawad, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; mood disorders; inflammation; oxidative stress; nitrosative stress; neuro-immune; antioxidants; psychoneuroimmunology

Online: 21 May 2021 (09:36:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0487.v1

Increased Nitro-Oxidative Toxicity in Association With Metabolic Syndrome, Atherogenicity and Insulin Resistance in Patients With Affective Disorders

Nayara Morelli, Michael Maes, Kamila Bonifacio, Heber Vargas, Sandra Nunes, Decio Barbosa

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Major depression; Bipolar disorder; Metabolic syndrome; oxidative and nitrosative stress, antioxidants; biomarkers.

Online: 18 March 2021 (15:56:56 CET)

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Working Paper ARTICLE

Portuguese Nurses’ Stress, Anxiety, and Depression Reduction Strategies During the COVID-19 Outbreak

Lara Guedes de Pinho, Francisco Sampaio, Carlos Sequeira, Laetitia Teixeira, César Fonseca, Manuel José Lopes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: anxiety; COVID-19; depression; mental health; mental health nurses; nurses; Portugal; stress

Online: 1 March 2021 (13:05:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0481.v1

Anxiety-Driven Cardiopulmonary Complaints during COVID-19 Pandemic Outbreak

Ofir Koren, Saleem Rajab, Mohammad Barbour, Moriah Shachar, Amit Shahar, Khaled Zubidat, Wasim Slim, Daher Igbariya3, Ehud Rozner, Yoav Turgeman, Einat Mader

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Anxiety, Depression; Chest Pain; Covid-19; Dyspnea; Emergency Department; Coronavirus; Decision-Making.

Online: 22 February 2021 (15:19:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0754.v1

Impact of Service User Video Presentations on Explicit and Implicit Stigma toward Mental Illness among Medical Students in Nepal: A Randomized Controlled Trial

Cori L. Tergesen, Dristy Gurung, Saraswati Dhungana, Ajay Risal, Prem Basel, Dipesh Tamrakar, Archana Amatya, Lawrence P. Park, Brandon A. Kohrt

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: attitudes; depression; developing countries; medical education; mental health; psychosis; service users; stigma

Online: 30 December 2020 (14:12:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0610.v1

Towards A New Model and Classification of Mood Disorders based on Risk Resilience, Neuro-Affective Toxicity, Staging, and Phenome Features Using the Nomothetic Network Psychiatry Approach

Michael Maes, Juliana Brum, Kamila Bonifacio, Decio Barbosa, Heber Vargas, Ana Paula Michelin, Sandra Nunes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: mood disorders; major depression; inflammation; neuro-immune; oxidative stress; nitrosative stress; biomarkers

Online: 25 September 2020 (11:48:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0347.v1

Increased Autoimmune Responses to Oxidative Specific Epitopes in Bipolar Disorder Type 1 and Major Depression: Towards A Data-Driven, Mechanistic Model of Mood Disorders

Drozdstoy Stoyanov, Jean–Claude Leunis, Marianna Murdjeva, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mood disorders; depression; nitrosative and oxidative stress; IgM autoimmunity; neuro-immune; inflammation

Online: 16 September 2020 (04:17:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0283.v1

Depression, Acculturative Stress and Social Connectedness among International University Students in Japan: prevalence and correlation.

Minh Hoang NGUYEN, Tam Tri LE, Serik MEIRMANOV

Subject: Social Sciences, Education Keywords: depression; acculturation stress; social connectedness; international students, university students, ASSIS, suicidal ideation

Online: 24 December 2018 (14:52:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0126.v2

Psychological Factors, Digital Health Technologies and Best Asthma Management: Three Fundamental Factors in Modern Care

Pasquale Caponnetto, Graziella Chiara Prezzavento, Mirko Casu, Maria Catena Quattropani

Subject: Public Health And Healthcare, Other Keywords: Asthma; eHealth; Mobile apps; Digital Health Interventions; Mixed Reality; Depression; Anxiety; Clinical Psychology

Online: 2 February 2024 (09:34:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1343.v1

Depressive Disorders and EU Labour Resources – the Problem of Lost Productivity in Highly Developed Economies

Agnieszka Jakubowska

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: indirect costs of depression; burden of disease; lost productivity; inequality in the EU

Online: 18 December 2023 (15:14:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1109.v2

Quality of Life and Incidence of Clinical Signs and Symptoms among Caregivers of Person with Mental Disorder

Vasiliki Oikonomou, Evgenia Gkintoni, Constantinos Halkiopoulos, Evangelos C Karademas

Subject: Public Health And Healthcare, Primary Health Care Keywords: clinical symptoms; caregivers; mental disorders; quality of life; stress; anxiety; depression; social support

Online: 15 December 2023 (12:16:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0556.v1

Genetic Psychophysiology and Markers of Resilience to Anxiety and Depression in Sports and Extreme Professions

Irma Mosse, Inna Charykova, Elena Stepanova, Darya Smetanina, Aleksei Riabinin, Nikita Sedlyar, Tatsiana Talako, Milos Ljubisavljevic, Yauhen Statsenko

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Sports; Psychogenetics; Psychophysiology; Elite athletes; Stress-resistance; Machine learning; Extreme professions; Depression; Anxiety

Online: 8 November 2023 (13:55:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1998.v1

Low Post-treatment Quality of Life and the High Incidence of Pain are Common and Significantly Exacerbated in Depressed Head and Neck Patients Treated with Definitive Accelerated Radiotherapy

Alicja Heyda, Dorota Księżniak-Baran, Andrzej Wygoda, Krzysztof Składowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: definitive accelerated radiotherapy; depression; chronic pain; head and neck cancer; quality of life

Online: 28 September 2023 (10:41:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1485.v1

Biomarkers of Postpartum Depression: A Narrative Review

Stefan Modzelewski, Aleksandra Julia Oracz, Kamila Iłendo, Aleksandra Sokół, Napoleon Waszkiewicz

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: postpartum depression, marker, biomarkers, peripartum, postpartum, cytokines, HPA, oxidative stress, genetics, nutrients, pathogenesis

Online: 22 September 2023 (05:13:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.0073.v1

Effects of Omega-3 Polyunsaturated Fatty Acids Intake on Vasomotor Symptoms, Sleep Quality and Depression in Postmenopausal Women: A Systematic Review

Ayesha Zafar Iqbal, Suet-Kei Wu, Halliru Zailani, Wei-Che Chiu, Wen-Chun Liu, Kuan-Pin Su, Shin-Da Lee

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: amenorrhea; depression; hot flashes; omega-3 PUFA; post-menopause; sleep quality; vasomotor symptoms

Online: 4 September 2023 (03:56:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1876.v1

Efficacy of a Symptom Self-Management Programme Delivered via Headset and Face-to-Face on Inpatients Post-Acute Myocardial Infarction: A Randomised Controlled Trial

Piyanee Klainin-Yobas, Lian Kwang Tang, Karen Wei Ling Koh, Anand Adinath Ambhore, Ping Chai, Ying Lau

Subject: Social Sciences, Psychiatry And Mental Health Keywords: acute myocardial infarction; anxiety; depression; stress; symptom self-management intervention; virtual reality device

Online: 29 August 2023 (03:42:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0392.v1

Mediation Effects of Social Cognition on the Relationship between Neurocognition and Social Functioning in Major Depressive Disorder and Schizophrenia

Takashi Uchino, Ryo Okubo, Youji Takubo, Akiko Aoki, Izumi Wada, Naoki Hashimoto, Satoru Ikezawa, Takahiro Nemoto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: ACSo; cognitive function; depression; PDQ; psychosis; real-world functioning; schizophrenia; SFS; social functioning

Online: 22 March 2023 (06:36:20 CET)

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