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Preprint ARTICLE | doi:10.20944/preprints201808.0455.v1

Anaemia and Incidence of Post Stroke Dementia

Phyo Kyaw Myint, Mary Joan Macleod, Allan B Clark, Toby O Smith, Joao H Bettencourt-Silva, Anthony Kneale Metcalf, John Potter

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Anaemia; Stroke; Dementia; Risk; Vascular Dementia; Post-stroke dementia

Online: 27 August 2018 (11:11:59 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202301.0427.v2

Using Smart Wearable Devices for Supporting Patients affected by Dementia in rural areas of Calabria

Alessandro Gallo, Salvatore Fregola, Margherita Menon, Filomena Talarico, Stella Fragkiadaki, Dyonisya Kontaxopoulou, Evangelia Stanitsa, Katarina Vukojevic, Danira Matijaca, Miodrag Milikovic, Srdjan Kozetinac, Alessio Merola, Vlado Dimovski, Anamarija Kejžar, Ivan Radevic, Danica Stevovic, Vlatika Martinovic, Katjia Matesan, Roberta Matkovic, Guido Piccoli, Elena Sodano, Amanda Gigliotti, Nicola Mayera, Elisabetta Pedace, Darjia Semrov, Pietro Hiram Guzzi

Subject: Computer Science And Mathematics, Hardware And Architecture Keywords: Wearable Device; Dementia

Online: 29 January 2023 (09:29:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201706.0034.v1

The Role of SNCA Rep1 Microsatellite in Parkinson’s Disease Progression

Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Comi Giacomo Pietro, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dementia; hallucinations; genetics

Online: 6 June 2017 (08:39:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0748.v1

Olfactory Bulb Proteomics Reveals Widespread Proteostatic Disturbances in Mixed Dementia and Guides for Potential Serum Biomarkers to Discriminate Alzheimer Disease and Mixed Dementia Phenotypes

Mercedes Lachén-Montes, Ignacio Iñigo-Marco, Paz Cartas-Cejudo, Joaquín Fernández-Irigoyen, Enrique Santamaría

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: mixed dementia; Alzheimer´s disease; vascular dementia; olfactory bulb; proteomics

Online: 28 April 2021 (11:03:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1991.v1

Diminished Self Reference Effect in Memory for Individuals with Dementia

Francesca Briscoe, Sanjay Kumar

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Dementia; Memory; Cognition; Self

Online: 29 August 2023 (14:19:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0261.v1

Essential Oil of Lippia origanoides H.B.K.: A Promising Compound Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

Aldenora Maria Ximenes Rodrigues, Brenda Nayranne Gomes dos Santos, Ranyelison Silva Machado, Rubens Renato de Sousa Carmo, Matheus Pedrosa de Oliveira, Antônia Maria das Graças Lopes Citó, Maria das Graças Freire de Medeiros Carvalho, Paulo Tércio dos Santos Leite

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Acetylcholinesterase; Dementia; Essencial oil

Online: 15 September 2021 (13:14:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1565.v1

Hard to Reach and Hidden: Improving Identification of Young Dementia Carers

Patricia Masterson-Algar, Kieren Egan, Greg Flynn, Gwenllian Hughes, Aimee Spector, Joshua Stott, Gill Windle

Subject: Social Sciences, Other Keywords: young person; young carer; adolescents; younger onset dementia; dementia; carer; admiral nurse; schools

Online: 25 October 2023 (08:42:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201906.0107.v1

Neuropharmacology of the neuropsychiatric symptoms of dementia: possible targets for novel therapeutic approaches

Damiana Scuteri, Laura Rombolà, Luigi Antonio Morrone, Giacinto Bagetta, Shinobu Sakurada, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corasaniti

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: dementia, behavioural and psychological symptoms of dementia, neuropsychiatric symptoms, aromatherapy, bergamot essential oil.

Online: 12 June 2019 (15:33:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0859.v1

Comorbidity of Type 2 Diabetes and Dementia Among Hospitalized Patients in Los Angeles County, 2019-2021

D’Artagnan M. Robinson, Dalia Regos-Stewart, Mariana A Reyes, Tony Kuo, Noel C Barragan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: diabetes; Alzheimer’s disease; dementia; hospitalization

Online: 13 October 2023 (08:26:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0297.v3

Insulin in Amyotrophic Lateral Sclerosis: Impairment, Tests and Treatment

Ari Rappoport

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ALS; frontotemporal dementia; insulin; diabetes

Online: 24 January 2023 (10:25:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0099.v1

Efficacy and Safety of Citalopram Compared to Atypical Antipsychotics on Agitation in patients with BPSD

Haider Qasim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: BPSD; antipsychotics; SSRIs; dementia; agitation

Online: 10 January 2022 (11:19:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0212.v1

Anaemia and Incidence of Post Stroke Dementia

Phyo Kyaw Myint, Mary Joan Macleod, Allan B. Clark, Toby O. Smith, Joao H. Bettencourt-Silva, Anthony Kneale Metcalf, John F. Potter

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; post-stroke dementia; anaemia

Online: 19 April 2019 (09:41:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0229.v1

Reaching Out to Rural Caregivers and Veterans with Dementia Utilizing Clinical Video-Telehealth

James S. Powers, Jennifer Buckner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: rural health; dementia care; telehealth

Online: 18 April 2018 (05:25:13 CEST)

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Context: A clinical video telehealth (CVT) program was implemented improve access and quality of dementia care to patients and their caregivers in rural areas. The program was offered as part of an established dementia clinic/geriatric primary care clinic in collaboration with five community-based outpatient clinics (CBOC’s) affiliated with the Tennessee Valley Healthcare System (TVHS) in middle Tennessee. Telehealth support was provided by a physician – social worker team visit. Methods: Telehealth training and equipment were provided to clinic personnel, functioning part-time with other collateral clinical duties. Patients and caregivers were referred by primary care providers and had an average of 1 to 2 CVT encounters originating at their local CBOC lasting 20 to 30 minutes. Clinical characteristics and outcomes of patients and caregivers receiving CVT support were collected by retrospective electronic medical record (EMR) review. Results: Over a 3-year period 45 CVT encounters were performed on patient-caregiver pairs, followed for a mean of 15 (1-36) months. Some 80% patients had dementia confirmed and 89% of these had serious medical comorbidities, took an average of 8 medications, and resided at a distance of 103 (76-148) miles from the medical center. Dementia patients included 33% with late stage dementia, 25% received additional care from a mental health provider, 23% took antipsychotic medications, 19% transitioned to a higher level of care, and 19% expired an average of 10.2 months following consultation. Caregiver distress was present in 47% of family members. Consult recommendations included 64% community-based long-term care services and supports (LTSS), 36% medications, and 22% further diagnostic testing. Acceptance of the CVT encounter was 98%, with 8770 travel miles saved. Conclusion: CVT is well received and may be helpful in providing dementia care and supporting dementia caregivers to obtain LTSS for high-need older adults in rural areas.

Preprint ARTICLE | doi:10.20944/preprints202311.1258.v1

‘Misdiagnosed and Misunderstood’: Insights into Rarer Forms of Dementia through a Stepwise Approach to Co-Constructed Research Poetry

Paul M Camic, Mary Pat Sullivan, Emma Harding, Martha Gould, Lawrence Wilson, Sam Sam Rossi-Harries, Adetola Grillio, Roberta McKee-Jackson, Susan M Cox, Joshua Stott, Emilie V Brotherhood, Gill Windle, Sebastian J Crutch

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: non-memory led dementia; young onset dementia; inherited dementia; care-partners; carers; caregivers; healthcare professionals; healthcare students; virtual environments; qualitative; arts and health

Online: 20 November 2023 (16:45:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0461.v1

The Case For Including Neuroprotective Factors in Sporadic Creutzfeldt-Jakob Questionnaires

Robert Reed

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Prion Disease; Creutzfeldt-Jakob; Diet; Dementia

Online: 27 February 2023 (08:42:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0384.v1

Marital Status with Rey Auditory Verbal Learning Test Cognition Performance Is Associated with Mild Cognitive Impairment

Yohn Jairo Parra Bautista, Samia Messeha, Carlos Theran, Richard A Alo, Clement G. Yedjou, Victor Adankai, Samuel Babatunde

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cognitive Test; Education; Cognitive Impairment; Dementia

Online: 25 October 2022 (09:37:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0214.v1

Explainable AI-based Alzheimer’s Prediction and Management Using Multimodal Data

Sobhana Jahan, Kazi Abu Taher, M Shamim Kaiser, Mufti Mahmud, Md. Sazzadur Rahman, A. S. M. Sanwar Hosen, In-Ho Ra

Subject: Engineering, Control And Systems Engineering Keywords: Machine learning; Dementia; Data-level fusion

Online: 15 March 2022 (12:31:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0308.v1

Role of Biomarkers for the Diagnosis of Prion Diseases

Miren Altuna, Iñigo Ruiz, Maria Victoria Zelaya, Maite Mendioroz

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: prion disease; biomarkers; diagnosis; dementia; neurodegeneration

Online: 24 February 2022 (10:00:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0522.v1

Dementia Risk and Prevention in Low and Middle-income Country Settings – Focus on Tanzania Mainland

Charles Kakilla

Subject: Social Sciences, Psychology Keywords: Dementia; prevalence; Tanzania; sustainable development goals

Online: 21 June 2021 (15:22:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0382.v1

Evaluation of the Adverse Effects of Chronic Exposure of Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments

Gilbert Audira, Nguyen Thi Ngoc Anh, Bui Thi Ngoc Hieu, Nemi Malhotra, Petrus Siregar, Omar Villalobos, Oliver B. Villaflores, Tzong-Rong Ger, Jong-Chin Huang, Kelvin H.-C. Chen, Chung-Der Hsiao

Subject: Social Sciences, Behavior Sciences Keywords: donepezil; acetylcholinesterase inhibitor; dementia; zebrafish; behavior

Online: 17 September 2020 (07:41:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1550.v1

Cognitive Impairment in Parkinson’s Disease: An Updated Overview Focusing on Emerging Pharmaceutical Treatment Approaches

Yildiz Degirmenci, Efthalia Angelopoulou, Vasiliki Epameinondas Georgakopoulou, Anastasia Bougea

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Parkinson' s disease; cognition; dementia, cognitive decline

Online: 22 August 2023 (09:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1896.v1

Nutrition and Outcome of 100 Endoscopic Gastrostomy Fed Citizens with Severe Dementia

Diogo Sousa-Catita, Paulo Mascarenhas, Cátia Oliveira, Miguel Grunho, Carla Adriana Santos, Jorge Fonseca

Subject: Public Health And Healthcare, Other Keywords: Severe Dementia; Nutritional status; Percutaneous Endoscopic Gastrostomy

Online: 26 May 2023 (08:56:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202112.0468.v1

Opioids in the Elderly Patients with Cognitive Impairment: A Narrative Review

Martina Rekatsina, Antonella Paladini, Dariusz Myrcik, Omar Viswanath, Ivan Urits, Joseph Pergolizzi, Frank Breve, Giustino Varrassi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: aging; elderly; pain; opioids; dementia; cognitive impairment

Online: 29 December 2021 (13:42:02 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202108.0302.v1

Nanoliposomes Reduce Stroke Injury Following Middle Cerebral Artery Occlusion in Mice

Saif Ahmad, Seth Truran, Nina Karamanova, Adam Kindelin, Maria Lozoya, Volkmar Weissig, Daniel Griffiths, Tyler Vail, Jonathan Lifshitz, Andrew F. Ducruet, Raymond Q. Migrino

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; liposome; cerebrovascular disease; oxidative stress; dementia

Online: 13 August 2021 (15:37:59 CEST)

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Working Paper REVIEW

Screening of Cognitive Changes in Adults with Intellectual Disabilities: A Systematic Review

Andreia F. Paiva, Adam Nolan, Charlotte Thumser, Flávia H. Santos

Subject: Social Sciences, Psychology Keywords: screening; dementia; intellectual disability; early-onset; neuropsychology

Online: 15 October 2020 (12:01:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0032.v1

A Homeostasis Breakdown Model of Subjective Cognitive Decline

Akiko Mizuno, Maria Ly, Howard J. Aizenstein

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: subjective cognitive decline; preclinical dementia; fMRI; compensation

Online: 2 November 2018 (07:17:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202102.0193.v1

New Therapeutic Approaches to Mild Cognitive Impairment and Mild Dementia: The Role of Ginkgo Biloba (EGb 761®)

Carlo Tomino, Sara Ilari, Vincenzo Solfrizzi, Valentina Malafoglia, Guglielmo Zilio, Patrizia Russo, Federica Marcolongo, Giovanni Scapagnini, Carolina Muscoli, Paolo Maria Rossini

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: mild cognitive impairment (MCI); mild dementia; Alzheimer’s disease; Ginkgo biloba (EGb761®); Tebonin; anti-dementia drugs; randomized controlled trials

Online: 8 February 2021 (11:37:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0170.v1

Quantitative Electroencephalography Markers for Accurate Diagnosis of Frontotemporal Dementia: A Spectral Power Ratio Approach

Jinwon Chang, Chul Chang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: electroencephalography; power ratio; frontal lobe; temporal lobe; dementia

Online: 3 October 2023 (16:21:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0513.v1

Mild Cognitive Impairment is not a Valid Concept and Should be Replaced by a More Restrictive, Biologically Validated Class, Named Mild Cognitive Dysfunctions (MCD): A Nomothetic Network Approach

Michael Maes, Sookjaroen Tangwongchai

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dementia; neurocognition; neuroimmune; oxidative stress; antioxidants; psychiatry; ageing

Online: 21 June 2021 (13:58:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0296.v1

Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia

Thitiporn Supasitthumrong, Chavit Tunvirachaisakul, Daruj Aniwattanapong , Sookjaroen Tangwongchai, Phenphichcha Chuchuen , Itthipol Tawankanjanachot , Thiti Snabboon, Solaphat Hemrungrojn , Andre F. Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: episodic memory, apolipoprotein, dementia, biomarkers, anion gap, inflammation

Online: 29 January 2019 (16:52:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0334.v1

Experiences of Carers and People With Dementia from Ethnic Minority Groups Managing Eating and Drinking at Home in The UK: A Qualitative Study

Pushpa Nair, Yolanda Barrado-Martín, Kanthee Anantapong, Kirsten Moore, Christina Smith, Elizabeth L. Sampson, Jill Manthorpe, Kate Walters, Nathan Davies

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Nutrition; Hydration; Dementia: Eating; Drinking; Food; Ethnic minorities; Culture

Online: 25 March 2022 (02:47:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0098.v1

New Hope for Behavioural and Psychological Symptoms in Dementia (BPSD): A Narrative Review of Clinical Studies Conducted in the Symptomatic Treatments for Agitation and Psychosis Episodes in Alzheimer’s Disease/Dementia

Haider Saddam Qasim, Maree Donna Simpson

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: BPSD; Alzheimer’s dementia; agitation; psychosis; SSRIs; antipsychotics; brexpiprazole; dextromethorphan

Online: 10 January 2022 (11:12:38 CET)

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Background: The psychomotor agitation of the BPSD is one of the common issues in aged care facilities, leading to the poor functional and medical consequences. Psychotropic interventions are the preferable choice of treatment. But which medication should be the prescribers first preference? This review aims to compare pharmacological interventions for psychomotor agitation, judging them according to their effectuality and justifiability profiles. This is to be achieved by retrieving information from RCTs and systematic reviews. Objectives: This review evaluates evidence from RCTs, systematic reviews, and meta-analyses of BPSD patients who had taken agitation treatments. Assessing the efficacy of antidepressants and antipsychotic treatments when compared to each other for the purpose of improving agitation outcomes. Methods: This narrative review includes RCTs and retrospective studies that were comparing one or more active ingredient medications with another or with a placebo, along with sys-tematic reviews comparing antidepressants with antipsychotics such as quetiapine, olanzapine, and risperidone. Studies extracted by searching accessing databases, such as PubMed, OVID, and Cochrane with restrictions of date from 2000 to 2021 and English language. Quality of evidence: The quality of systematic reviews was judged against AMSTAR score, and RCTs were judged according to CONSORT checklist for RCT protocols. Conclusion: There are still few studies of serotonin targeting treatment of agitation in BPSD. The SSRIs such as citalopram were associated with a reduction in symptoms of agitation, and lower risk of adverse effects compared to antipsychotics. This review also illustrates brexpiprazole as a target of multimodal neurotransmitters such as dopamine, serotonin, and norepinephrine; and dextromethorphan, OR dextromethorphan associated with bupropion or quinidine as a blockade of NMDA receptors. The outcome of this review suggests that further studies involving more dementia/Alzheimer’s participants should be conducted. Future studies are required also to assess the long-term safety and efficacy of SSRI, brexpiprazole, dextromethorphan treatments for agitation in BPSD.

Preprint ARTICLE | doi:10.20944/preprints202011.0341.v1

Cost-Effectiveness of Olanzapine and Risperidone in Treatment of Patients with Behavioural and Psychological Symptoms of Dementia in Thailand

Oranuch Thongchandee, Khaled Khatab, Maruf Raheem

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Dementia; Olanzapine; Risperidone; BPSD; Markov model; Sensitivity analyses; Thailand

Online: 12 November 2020 (10:28:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0377.v1

Distinct Subgroups of Amnestic Mild Cognitive Impairment as Identified by Soft Independent Modeling of Class Analogy

Sookjaroen Tangwongchai, Itthipol Tawankanjanachot , Chavit Tunvirachaisakul, Thitiporn Supasitthumrong, Solaphat Hemrungrojn , Phenphichcha Chuchuen , Thiti Snabboon, André Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dementia; AGAP; bicarbonate; cognitive function; Mild cognitive impairment; CERAD

Online: 31 May 2019 (08:31:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0173.v1

Proposing Intranasal Rifampin for Alzheimer’s Disease and the Other Age-Related Neurodegenerative Proteinopathies

Coad Thomas Dow, Laith Kidess

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: ifampin; proteinopathies; permeability glycoprotein; intranasal; bi-directional; Alzheimer’s; Parkinson’s; Lewy body dementia; multiple system atrophy; huntington’s; amyotrophic lateral sclerosis/frontotemporal dementia spectrum

Online: 10 February 2023 (02:31:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2007.v1

Explainable Artificial Intelligence on Social Support, Poor Self-Rated Health and Dementia

Hye Gyeong Jeong, Chae-Won Kim, Hyuntae Park, Kwang-Sig Lee

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: self-rated health; dementia; family support; friendship activity; artificial intelligence

Online: 28 September 2023 (11:45:15 CEST)

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This study uses explainable artificial intelligence to analyze major predictors of poor self-rated health, dementia and their comorbidity, which include various aspects of social support. Data came from the Korean Longitudinal Study of Ageing (2016-2018), with 5527 participants aged 56 or more. The dependent variables were: (1) poor self-rated health (SRH) with 5 categories (very good, good, middle, poor, very poor); (2) dementia (no, yes); and (3) their comorbidity with 4 categories (SRH very good, good or middle, dementia no; SRH very good, good or middle, dementia yes; SRH poor or very poor, dementia no; SRH poor or very poor, dementia yes). The 49 demographic, socioeconomic and health-related predictors were included. The accuracy and area under the receiver operating characteristic curve (AUC) were compared for logistic regression and the random forest. Logistic regression and the random forest registered similar AUCs with the range of 0.80-0.87. Based on random forest variable importance, 18 out of top-20 predictors were identical for SRH, dementia and their comorbidity: previous SRH, life satisfaction - health, age, body mass index, income, chronic diseases, life satisfaction - economic, life satisfaction - overall, grandchildren alive, friendship meeting, brothers/sisters alive, class identity, children alive, social activity - friendship, education, children in weekly contact, religion and drinker. However, some variations were found among the three dependent variables, i.e., previous SRH for comorbidity (1st) and SRH (1st) compared to dementia (11th), grandchildren alive for SRH (6th) and dementia (4th) compared to comorbidity (9th), chronic diseases for comorbidity (6th) compared to SRH (10th) and dementia (10th). In terms of Shapley Additive Explanation (SHAP) values, the probability of dementia is expected to decrease by 5.57% in case a predictor grandchildren alive is included to the model. This study highlights the importance of social support for the prediction of poor self-rated health, dementia and their comorbidity. Specifically, the promotion of family support and friendship activity for elders would be vital for the prevention and management of their self-rated health and dementia.

Preprint ARTICLE | doi:10.20944/preprints202302.0245.v1

Applicability of the Hungarian Version of the Test Your Memory in General Practice for Screening Mild Cognitive Impairment and Early Stage Dementia

Szabolcs Garbóczy, András Mohos, Anikó Égerházi, Anita Szemán-Nagy, János András Zsuffa, Szilvia Heim, Viktor Rekenyi, László Róbert Kolozsvári

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dementia; mild cognitive impairment; elderly; primary care; GP; family physician

Online: 15 February 2023 (01:36:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0001.v1

Bright Morning Light Enhances Parasympathetic Activity at Night: A Pilot Study of Older People with Dementia, without a Pacemaker

Chuen-Ru Liu, Terry B. J. Kuo, Jwo-Huei Jou, Chun-Ting Lai Lai, Yu-Kai Chang, Yiing Mei Liou

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: light therapy; dementia; heart rate variability; cognitive function; parasympathetic; sympathetic

Online: 3 January 2023 (02:27:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0267.v1

A single-case design investigation for measuring the efficacy of Gestalt therapy to treat depression in older adults with dementia in Italy and in Mexico: a research protocol

Alessandra Merizzi, Rosanna Biasi, José Fernando Álvarez Zamudio, Margherita Spagnuolo Lobb, Sara Santini

Subject: Social Sciences, Psychology Keywords: Gestalt therapy; dementia; depression; single-case experimental design; psychosocial interventions

Online: 19 January 2022 (09:32:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0722.v1

Feasibility of a Multicomponent Training for People with Moderate to Severe Dementia Living in a Long-Term Care Home – Social Ethical Approach

Adele Kruse, Thomas Cordes, Steffen Schulz, Bettina Wollesen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Dementia; multicomponent training; long-term care home; social ethical approach

Online: 31 May 2021 (09:45:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0363.v1

Dementia Literacy in Greater Bay Area, China: Identifying the At-risk Population and the Preferred Mass Media for Receiving Dementia Information

Angela Yee Man Leung, Alex Molassiotis, June Zhang, Renli Deng, Ming Liu, Iat Kio Van, Cindy Siu U Leong, Isaac S.H. Leung, Doris Y. P. Leung, Xiaoling Lin, Alice Y Loke

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: health literacy; dementia; cross-sectional study; community; Alzheimer's Disease; knowledge

Online: 27 December 2019 (10:34:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0335.v2

Metabolic and Hormonal Contributors to Neuronal Necrosis in Alzheimer’s Dementia

Michael Overholt

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s Dementia; anaerobic neurotoxicity; inflammation; neuronal apoptosis; Non-REM Sleep

Online: 4 June 2018 (13:16:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0848.v1

Association of Plasma Claudin-5 with Age and Alzheimer Disease

Keisuke Tachibna, Ryuichi Hirayama, Naoyuki Sato, Kotaro Hattori, Takashi Kato, Hiroyuki Takeda, Masuo Kondoh

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: blood-brain barrier; claudin-5; tight junction; biomarker; dementia; Alzheimer disease

Online: 14 November 2023 (11:27:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0371.v1

The Role of Zinc in Neurodegenerative Diseases and the Potential of Carnosine as Their Therapeutic Agent

Dai Mizuno, Masahiro Kawahara, Keiko Konoha–Mizuno, Terumasa Ogawara, Kentaro Yamazaki

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: apoptosis; carnosine; endoplasmic reticulum stress; Parkinson’s disease; synapse; vascular dementia; zinc

Online: 6 July 2023 (07:50:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1184.v1

Diagnosing Alzheimer's Disease Levels Using Machine Learning and MRI: A Novel Approach

Reza Bahadori, Ali Akbar Kiaei, Hourieh Malek Zadeh, Mahnaz Boush, Sadegh Abadijou, Danial Safaei, Amir Hossein Mehdikhani

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Alzheimer's disease; neurological illness; dementia; machine learning; Magnetic Resonance Im-aging

Online: 16 June 2023 (07:28:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0341.v1

Effectiveness of a Woodworking Program on Psychosocial Health among Older Adults with Cognitive Impairment

Hyun-Joo Lee, Si-Woo Ban, Ha-Yun Chung, Myoung-Ok Jeon, Kye-Yean Kim, Ja-Eun Kim, Ki-Woung Lim, Chang-Ick Choi, Don-ha Choi, Ui-Do Hwang, Won-Chul Shin, Hye-Ri Shin, Young-Sun Kim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: woodworking program; MCI; mild dementia; psychological health; social health; older adults

Online: 17 November 2022 (16:13:43 CET)

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Preprint REVIEW | doi:10.20944/preprints202204.0022.v1

Psychosocial Risk Factors for Alzheimer's Disease in Down Syndrome Patients and their Association with Brain Changes: A Narrative Review

Osama Hamadelseed, Ibrahim H. Elkhidir, Thomas Skutella

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; Corpus callosum; Dementia; Down syndrome; Hippocampus; Psychosocial Risk Factors

Online: 5 April 2022 (09:38:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0001.v1

Dual-Task Effect on Cognitive and Body Function, β-amyloid Levels in Alzheimer's Dementia Patients: a Randomized Controlled Trial

Seung Min Nam, SEONG-GIL KIM

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Alzheimer’s Disease; Task Performance; Cognition; Human Activities; Amyloid Beta Protein; Dementia

Online: 2 November 2020 (08:06:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0536.v1

Depression, Loneliness, Activities of Daily Living, Social Support, and Life Satisfaction in Older Adults at High-Risk for Dementia

Sunghee Kim, Heesook Son, Kwisoon Choe, Kyoungsook Lee

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: dementia; depression; loneliness; activities of daily living; social support; life satisfaction

Online: 27 October 2020 (07:55:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0022.v1

Therapeutic Gardens – A healing environment for optimizing the health care experience of Alzheimer’s and dementia patients: A narrative review

Patrick Uwajeh, Mukaddes Polay, Timothy Onosahwo Iyendo

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Alzheimer’s disease; dementia; therapeutic environment; Virtual reality; Stress recovery; therapeutic gardens

Online: 2 October 2018 (11:03:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0227.v1

The Impact of Apolipoprotein E (APOE) Epigenetics on Aging and Sporadic Alzheimer’s Disease

Madia Lozupone, Vittorio Dibello, Rodolfo Sardone, Fabio Castellana, Roberta Zupo, Luisa Lampignano, Ilaria Bortone, Antonio Daniele, Antonello Bellomo, Vincenzo Solfrizzi, Francesco Panza

Subject: Biology And Life Sciences, Aging Keywords: apolipoprotein E; Alzheimer’s disease; methylation; dementia; epigenetics; tau protein; amyloid-β; longevity

Online: 3 November 2023 (10:00:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0699.v1

Analysis of Potential Biomarkers in Frontal Temporal Dementia: A Bioinformatics Approach

Inara Deedar Momin, Jessica Rigler, Kumaraswamy Naidu Chitrala

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Frontal Temporal Dementia; Comorbidity; Breast cancer; COVID-19; Differential Gene expression analysis

Online: 9 August 2023 (09:04:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0380.v1

Treating Depression in Clinical Practice: New Insights on the Multidisciplinary Use of Tradozone

Umberto Albert, Carmine Tomasetti, Camillo Marra, Francesca Neviani, Alessandro Pirani, Daiana Taddeo, Orazio Zanetti, Giuseppe Maina

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; neurological disorders; dementia; primary care

Online: 22 February 2023 (08:42:51 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0497.v1

Association between Periodontal Disease and cognitive impairment in Adults

Najwane Said-Sadier, Batoul Sayegh, Raymond Farah, Linda Abou Abbas, Rania Dweik, Norina Tang, David M. Ojcius

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: cognitive impairment; dementia; oral pathogens; periodontitis; inflammatory biomarkers; anti-bodies; systematic review

Online: 27 December 2022 (01:41:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0241.v1

Diabetes Mellitus: A path to Amnesia, Personality and Behavior Change.

Rahnuma Ahmad, Kona Chowdhury, Santosh Kumar, Mohammed Irfan, Govindool Sharaschandra Reddy, Farhana Akter, Dilshad Jahan, Mainul Haque

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Diabetes Mellitus; Vascular Dementia; Alzheimer’s Disease; Inflammation; Atherosclerosis; Mitochondrial dysfunction; Cognitive dysfunction

Online: 17 January 2022 (15:46:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0568.v1

Perceived Help-Seeking Difficulty, Barriers, Delay, and Burden in Carers of People with Suspected Dementia

Carmen KM Ng, Dara KY Leung, Xinxin Cai, Gloria HY Wong

Subject: Business, Economics And Management, Accounting And Taxation Keywords: service accessibility; dementia knowledge; affordability; carer role strain; self-criticism; negative emotions

Online: 27 January 2021 (16:15:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0809.v1

Higher Prevalence of Dementia but No Improvement in Total Comfort While Dying Among Nursing Home Residents With Dementia Between 2010 and 2015: Results From Two Retrospective Epidemiological Studies

Rose Miranda, Tinne Smets, Nele Van Den Noortgate, Luc Deliens, Lieve Van den Block

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Long-term care; care homes; nursing homes; dementia; quality improvement; palliative care

Online: 31 December 2020 (13:16:03 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201909.0346.v1

A Customized NGS-Based Resequencing Gene Panel to Identify Genetic Variants in Dementing Disorders: Preliminary Results

Giuseppe Lanza, Francesco Calì, Mirella Vinci, Filomena Irene Ilaria Cosentino, Mariangela Tripodi, Rosario Sebastiano Spada, Mariagiovanna Cantone, Rita Bella, Teresa Mattina, Raffaele Ferri

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: neurogenetics; dementia; next-generation sequencing; in silico analysis; genetic variant; phenotypic variability

Online: 30 September 2019 (11:05:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0822.v1

Correlates of Functional Impairment in Patients with the Behavioral Variant of Frontotemporal Dementia: A PRISMA-Compliant Systematic Review

Electra Chatzidimitriou, Panagiotis Ioannidis, Eleni Aretouli, Vasileios Papaliagkas, Despina Moraitou

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: behavioral variant of frontotemporal dementia; correlates; functional impairment; predictive factors; PRISMA; systematic review

Online: 10 August 2023 (05:47:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2112.v1

Why an Antioxidant Complex Twendee X® Prevent Dementia?

Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, Haruhiko Inufusa

Subject: Biology And Life Sciences, Aging Keywords: Alzheimer's disease; oxidative stress; Twendee X®︎; antioxidant; dementia; mitochondria; reactive oxygen species

Online: 1 August 2023 (02:49:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0135.v1

Rare Amyloid Precursor Protein Point Mutations Recapitulate Worldwide Migration and Admixture in Healthy Individuals: Implications For the Study of Neurodegeneration

Paolo Abondio, Francesco Bruno, Amalia Cecilia Bruni, Donata Luiselli

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: amyloid; Alzheimer’s disease; neurodegenerative diseases; neurodegeneration; dementia; population genomics; migration; admixture; APP; neuropathology

Online: 8 November 2022 (02:10:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0032.v1

Dysbiosis in Alzheimer’s Disease Might be Triggered by Certain Classes of Antibiotics with Time-lapse: New Insights in the Pathogenesis?

Gábor Ternák, Márton Németh, Martin Rozanovic, Lajos Bogár

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: antibiotic consumption; gut flora; dysbiosis; Alzheimer disease; dementia; gut-brain axis, mediator molecules

Online: 5 January 2022 (10:44:59 CET)

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Background and objectives: Alzheimer's disease (AD) is a progressive neurodegenerative illness, responsible for 60-70% of all dementias, affecting over 50 million people worldwide, and nearly 11 million in European countries. Several putative factors are identified in the literature as causative agents or risk factors for the development of AD. The amyloid cascade hypothesis has been the main hypothesis about the pathophysiology of AD for decades. Recent studies raised the possible role of dysbiosis in the development of AD which prevents memory loss. The amyloid-β (Aβ) deposition might be considered as an inflammatory reaction to certain molecular products arising from the altered microbiome. Based on the above observations, it has been suspected, that antibiotic consumption patterns of different antibiotic classes might be associated with the prevalence of AD in European countries. Methods: Antibiotic consumption (ECDC) for 1997-2007, 2008-2018, and as the whole 1997-2018 period, have been compared to the AD prevalence for 2018 expressed in percentage of the population and statistically analyzed by Pearson calculation. Results: A significant positive correlation has been found between the AD prevalence (2018) and the average quinolone consumption for the year 1997-2007 (p: 0.044). A similar association was not observed for the entire 22 years (1997-2018) of the average quinolone consumption, and the years 2008-18, indicating 10-20 years of time-lapse between the antibiotic exposure and the development of AD. The ratio of broad-spectrum and narrow-spectrum antibiotics (B/N) estimated in the ECDC database for the years of 2008-2018 showed a strong positive association with AD prevalence (2018) (p: 0.026) and a positive correlation tendency for the entire 22 years 1997-2018 (p: 0.063), but none for the years 1997-2007 (p: 0.241). Broad-spectrum, beta-lactamase sensitive penicillin (J01CA) consumption showed a positive (non-significant) correlation with the prevalence of AD for the years 2008-2018 (p:0.080).Discussion: Our study indicated the possible sequential role of certain classes of antibiotics in the development of dysbiosis leading to amyloid deposits of AD, which strengthen the possible role of different mediator molecules (short-chain fatty acids, lipopolysaccharides, etc.) produced by the altered microbiome in the development of AD.

Preprint ARTICLE | doi:10.20944/preprints202102.0502.v1

Correlation Between the Bilingual Status and the Onset Age of AD and MCI Subjects: Evidence from the ADNI Dataset

Jason Li, Yang Han, Jacqueline Lam, Victor Li, Stephen Matthews, Lawrence Cheung, Virginia Yip, Jocelyn Downey, Danny Chan, Illana Gozes

Subject: Social Sciences, Language And Linguistics Keywords: Alzheimer's Disease; Onset Age; Bilingualism; Cognitive Reserve; Dementia; Mild Cognitive Impairment; ADNI database

Online: 23 February 2021 (09:20:19 CET)

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Background: This paper investigates the statistical relationship between bilingualism and the Onset Age (OA) of AD and MCI across a clinical sample, consisting of 580 Alzheimer's Disease (AD) subjects and 1264 Mild Cognitive Impairment (MCI) subjects, via a statistical analysis conducted on the sample retrieved from the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Method: To investigate whether bilingualism has any correlation with the OAs of AD or MCI subjects, our study leverages the full potential of the ADNI dataset, a dataset that covers both the OA and the bilingualism status of both the AD and MCI subjects. Prior to performing any meaningful statistical analysis, a regression model and a probabilistic model were developed in parallel to fill in the missing OA and bilingualism values. A simple least-square regression model that consists of an independent variable of registered age for Mini-Mental State Examination (MMSE) score was used to estimate the OA of the AD and MCI subjects in the ADNI dataset. After filling in the missing OA values, the number of subjects relevant for the statistical analysis increased from 816 (AD: 371, MCI: 445) to 1844 (AD: 580, MCI: 1264), which greatly enlarged the representation of the AD and MCI sample in the ADNI population. With increased sample size, a novel probabilistic classification model was introduced to infer an ADNI subject’s bilingualism when relevant demographic information and deterministic outcome were not readily available from the ADNI dataset. The weighted average OA for the bilinguals and the monolinguals was then computed, where the weights for the probabilistic labels were assigned based on the percentage of bilingualism in the general US population. Finally, a statistical analysis was performed to test whether any statistically significant correlation exists between the OA and the bilingualism of the AD and MCI subjects within the ADNI dataset. Findings: Our preliminary study demonstrates no significant statistical difference between the OA of the bilinguals and the monolinguals within the ADNI dataset. Thus, the monolingual speakers within the ADNI dataset do not statistically manifest earlier onset, as compared to the bilingual speakers, which is slightly inconsistent with some earlier statistical findings that bilingual speakers enjoy certain distinctive advantages, such as late onset of AD, as compared to monolingual counterparts.

Preprint ARTICLE | doi:10.20944/preprints202101.0147.v1

A Proposed Model of Dehumanisation and Its Relevance to Dehumanisation in Dementia Care

Hana Speering, Lara Speering

Subject: Social Sciences, Psychology Keywords: Dehumanisation; dementia care; healthcare education; residential aged care facilities; positive dehumanisation; negative dehumanisation

Online: 8 January 2021 (11:23:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1970.v1

Controlling Gut Microbiota by Twendee X®︎ Also Contributes to Dementia Prevention

Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, Haruhiko Inufusa

Subject: Biology And Life Sciences, Aging Keywords: Alzheimer’s disease; Dementia; Twendee X; microbiome; gut microbiota; Oxidative stress; Quality of life; antioxidant

Online: 31 October 2023 (05:16:08 CET)

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The human gut microbiota (GM) is a complex and dynamic ecosystem that hosts trillions of commensal and potentially pathogenic microorganisms. It is crucial in protecting humans from pathogens and in maintaining immune and metabolic homeostasis. Numerous studies have demonstrated that GM has a significant impact on health and disease, including Alzheimer’s disease (AD). AD is a progressive neurodegenerative disorder characterized by impaired short-term memory and cognitive deficits. Patients with AD have been reported to exhibit abnormalities in GM density and species composition. Oxidative stress (OS) has been implicated in the onset and progression of AD, however, the relationship between OS and gut microbiota in AD onset and progression is not clear. Twendee X®︎ (TwX), an oral supplement consisting of 8 active ingredients, has been shown to prevent dementia in mild cognitive impairment (MCI) in humans and substantially improve cognitive impairment in mouse models of AD. This positive effect is achieved through the potency of the combined antioxidants that regulate OS and therefore similar results cannot be achieved by a single antioxidant ingredient. To examine the impact of long-term OS elevation as seen in AD on the body and GM, we examined GM alterations during the initial OS elevation using a rat 2-week OS loading model, and examined the effects of TwX on OS and GM. Furthermore, using a questionnaire survey and fecal samples, we analyzed the impact of TwX on healthy individuals' gut bacteria and the associated effect on their quality of life (QOL). TwX was found to increase the number of bacteria species and their diversity in GM, as well as butyrate-producing bacteria, which tend to be reduced in AD patients. Additionally, TwX improved defecation condition and QOL. The gut bacteria function as part of the homeostatic function during OS elevation, and prophylactic administration of TwX strengthened this function. The results suggests that the preventative effect of TwX on dementia may involve the GM in addition to the other effects previously demonstrated.

Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0091.v1

A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-derived Basal Forebrain Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease Modeling

Sonia Sanz Muñoz, Martin Engel, Rachelle Balez, Dzung Do-Ha, Mauricio Castro Cabral-Da-Silva, Damian Hernández, Tracey Berg, Jennifer Fifita, Natalie Grima, Shu Yang, Ian Blair, Garth Nicholson, Anthony Cook, Alex Hewitt, Alice Pébay, Lezanne Ooi

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: induced pluripotent stem cells; disease modelling; neuronal differentiation; cholinergic neurons; Alzheimer’s disease; frontotemporal dementia

Online: 4 August 2020 (11:17:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0345.v1

Classification of Alzheimer's Disease with and without Imagery Using Gradient Boosted Machines and ResNet-50

Lawrence V. Fulton, Diane Dolezel, Jordan Harrop, Yan Yan, Christopher P. Fulton

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s Disease; Extreme Gradient Boosting; Deep Residual Learning; conolutional neural networks; machine learning; dementia

Online: 31 July 2019 (04:33:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0050.v1

Nanotherapy for Early Dementia: Targeting Senile Endothelium

Joseph S. D'Arrigo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's-disease; dementia; drug targeting; nanoemulsion; neuroinflammation; oxidative stress; scavenger receptors; sonoporation; transcranial ultrasound

Online: 13 September 2017 (05:44:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0627.v1

The Association between Coffee and Tea Consumption at Midlife and Risk of Dementia Later in Life: The HUNT Study

Denise Abbel, Bjørn Olav Åsvold, Marit Kolberg, Geir Selbæk, Raymond Noordam, Håvard Kjesbu Skjellegrind

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: coffee consumption; tea consumption; mild cognitive impairment; dementia; Alzheimer’s disease; nutrition; epidemiology; apolipoprotein E; MCI

Online: 20 April 2023 (07:55:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0533.v1

Biomarkers of neurodegeneration in post-traumatic stress disorder: an integrative review

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: post-traumatic stress disorder; dementia; Parkinson’s disease; β-amyloid; inflammation; hippocampus; white matter integrity; genetics

Online: 31 March 2023 (02:12:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0197.v1

Alpha-Synuclein at the Interface between Depression, Parkinson’s Disease and Dementia: Evidence from Epidemiology, Population Genetics and Gene-Environment Interactions

Ravi Philip Rajkumar

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: alpha-synuclein; SNCA; major depression; dysthymia; Parkinson’s disease; dementia; neurodegeneration; gene-environment interaction; PM2.5; pesticides

Online: 14 September 2022 (08:38:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0011.v1

Development of a Needs-Based Essential Care Service Package for Institutional Dementia Care in China

Tongda Sun, Hongdao Meng, Mingze Zhu, Xiaoxin Dong, Naidan Tu, Ning Sun, Rangcheng Jia

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Elderly with dementia; needs; utilization; essential care service package; long-term care system; health policy

Online: 1 February 2021 (11:24:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0062.v1

Effects of Carotid Artery Stent (CAS) on Cognitive Function in Patients with Symptomatic Carotid Stenosis using MoCa Scale and Neuroimaging Test

José Andres Guirola, Juan Ramon y Cajal, María José Gimeno, Carlos Tejero, María Cruz Piquero, Masao Yamamoto-Ramos, Miguel Angel De Gregorio

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: carotid stenosis; self expandable metallic stents; magnetic resonance spectroscopy; mental status and dementia tests; radiology; interventional

Online: 1 November 2023 (10:32:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.1473.v1

Towards a Better Diagnosis and Treatment of Dementia: Identifying Common and Distinct Neuropathological Mechanisms in Alzheimer’s Disease and Vascular Dementia

Alisa Vollhardt, Lutz Frölich, Anna Christina Stockbauer, Adrian Danek, Christoph Schmitz, Anna-Sophia Wahl

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer`s, vascular dementia, neurovascular unit, neurovascular coupling, impaired blood brain barrier, neurotoxic metabolites, endothelial damage

Online: 21 September 2023 (11:28:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0081.v1

An Acoustic-based Smart Home System for People Suffering from Dementia

Eleni Boumpa, Anargyros Gkogkidis, Ioanna Charalampou, Argyro Ntaliani, Athanasios Kakarountas, Vasileios Kokkinos

Subject: Computer Science And Mathematics, Hardware And Architecture Keywords: Active and Assisted Living; smart speakers; information support system; health care system; sufferer monitoring system; dementia

Online: 6 March 2019 (12:21:55 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0204.v1

Targeted Nanotherapy for Cognitive Impairment: Blocking Amyloid-β-Induced Membrane Damage in Brain Tissue

Joseph D'Arrigo

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Alzheimer's disease; blood-brain barrier; cognitive aging; cognitive impairment; dementia; drug targeting; nanoemulsion; nanocarriers; scavenger receptors

Online: 10 August 2018 (12:28:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2187.v1

Effects of diabetes mellitus related dysglycemia on the functions of blood-brain barrier and the risk of dementia

Mateusz Wątroba, Anna D. Grabowska, Dariusz Szukiewicz

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: diabetes mellitus; blood-brain barrier disruption; dysglycemia; hyperglycemia; insulin resistance; neurodegenerative disease; diabetic complications; dementia, diabetic encephalopathy

Online: 31 May 2023 (10:05:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0106.v2

Chemical Vapour Deposition Graphene Field-Effect Transistors for Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker

Carrie Haslam, Samar Damiati, Toby Whitley, Paul Davey, Emmanuel Ifeachor, Shakil A. Awan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: graphene; electrochemical biosensors; cancer; diagnosis; electrical detection; Alzheimer’s disease; dementia; neurodegenerative disorders; cardiovascular; blood biomarkers; antibodies; proteins

Online: 2 January 2018 (05:21:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0197.v1

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Duc Le, Lindsay Brown, Kundan Malik, Shin Murakami

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance

Online: 13 October 2021 (11:04:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0190.v1

Targeting Early Dementia: Using Lipid Cubic-Phase Nanocarriers to Cross the Blood-Brain Barrier

Joseph S. D'Arrigo

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Alzheimer’s disease; biomimetic nanocarriers; blood-brain barrier; dementia; drug targeting; lipid cubic phases; nanoemulsion; SR-BI; scavenger receptors

Online: 28 February 2018 (07:49:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0210.v1

Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease

Sama Jaberi, Margaret Fahnestock

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Brain-derived neurotrophic factor (BDNF); Alzheimer’s disease; exercise; osteocalcin; FNDC5/irisin; lactate; APP processing; dementia; cognition; learning and memory

Online: 5 September 2023 (03:45:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2123.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (13:14:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2095.v1

Can Nutrition Contribute to a Reduction in Sarcopenia, Frailty, and Comorbidities in a Super-Aged Society?

Sadao Yoshida, Ryo Shiraishi, Yuki Nakayama, Yasuko Taira

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: sarcopenia; frailty; comorbidity; diabetes; chronic kidney disease (CKD); heart failure; dementia; vitamin D; oral nutritional supplement (ONS); elderly people

Online: 29 June 2023 (11:05:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0625.v1

Licensed Anti-Microbial Drugs Logical for Clinical Trials Against Pathogens Currently Suspected in Alzheimer's Disease

Leslie C. Norins

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; dementia, beta-amyloid; germ theory; drug development; clinical trials; herpes; spirochetes; Chlamydia pneumoniae; Porphyromonas gingivalis; toxoplasma; mycobacteria

Online: 29 January 2021 (13:57:18 CET)

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Preprint REVIEW | doi:10.20944/preprints201702.0020.v1

Potential Modes of Intercellular Alpha-Synuclein Transmission

Dario Valdinocci, Rowan A. W. Radford, Sue Maye Siow, Roger S. Chung, Dean L. Pountney

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: alpha-synuclein; Parkinsons disease; dementia with Lewy bodies; multiple system atrophy; tunelling nanotube; glymphatic system; cell-to-cell spread

Online: 7 February 2017 (03:24:21 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202310.2100.v1

The Role of Furin on the Pathogenesis of COVID-19 Associated Neurological Disorders

Gunel Ayyubova, Sergiy G. Gychka, Sofia I. Nikolaienko, Nataliia V. Shults, Yuichiro J. Suzuki

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; Angiotensin II; Angiotensin-converting enzyme 2; COVID-19; Brain; Dementia; Furin; Neurological disorders; SARS-CoV-2; Spike protein.

Online: 31 October 2023 (14:53:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0297.v1

Applying Artificial Intelligence Techniques to Improve Clinical Diagnosis of Alzheimer’s Disease

Ahmed Abdullah Farid, Gamal Selim, Hatem Khater

Subject: Computer Science And Mathematics, Information Systems Keywords: Data Mining; Alzheimer’s Dementia; Composite Hybrid Feature Selection; Machine learning; Stack ‎Hybrid Classification; AI Techniques; Classification; AD Diagnose; Clinical AD Dataset

Online: 19 March 2020 (10:52:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0299.v1

Applying Artificial Intelligence Techniques for Prediction of Neurodegenerative Disorders: A Comparative Case-Study on Clinical Tests and Neuroimaging Tests with Alzheimer’s Disease

Ahmed Abdullah Farid, Gamal Selim, Hatem Khater

Subject: Computer Science And Mathematics, Information Systems Keywords: Data Mining; Alzheimer’s Dementia; Composite Hybrid Feature Selection; Machine learning; stack ‎Hybrid Classification; AI; MRI; Neuroimaging; MPEG7 edge histogram feature extraction; CNN

Online: 19 March 2020 (11:25:01 CET)

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Alzheimer's disease (AD) detection acting as an essential role in global health care due to misdiagnosis and sharing many clinical sets with other types of dementia, and costly monitoring the progression of the disease over time by magnetic reasoning imaging (MRI) with consideration of human error in manual reading. This paper goal a comparative study on the performance of data mining techniques on two datasets of Clinical and Neuroimaging Tests with AD. Our proposed model in the first stage, Apply clinical medical dataset to a composite hybrid feature selection (CHFS), for extract new features to select the best features due to eliminating obscures features, In parallel with Apply a novel hybrid feature extraction of three batch edge detection algorithm and texture from MRI images dataset and optimized with fuzzy 64-bin histogram. In the second stage, we applied a clinical dataset to a stacked hybrid classification(SHC) model to combine Jrip and random forest classifiers with six model evaluations as meta-classifier individually to improve the prediction of clinical diagnosis. At the same stage of improving the classification accuracy of neuroimaging (MRI) dataset images by applying a convolution neural network (CNN) in comparison with traditional classifiers, running on extracted features from images. The authors have collected the clinical dataset of 426 subjects with (1229 potential patient sample) from oasis.org and (MRI) dataset from a benchmark kaggle.com with a total of around ~5000 images each segregated into the severity of Alzheimer's. The datasets evaluated using an explorer set of weka data mining software for the analysis purpose. The experimental show that the proposed model of ‏(CHFS) feature extraction ‏ lead to effectively reduced the false-negative rate with a relatively high overall accuracy with a stack hybrid classification of support vector machine (SVM) as meta-classifier of 96.50% compared to 68.83% of the previous result on a clinical dataset, Besides a compared model of CNN classification on MRI images dataset of 80.21%. The results showed the superiority of our CHFS model in predicting Alzheimer's disease more accurately with the clinical medical dataset in early-stage compared with the neuroimaging (MRI) dataset. The results of the proposed model were able to predict with accurately classify Alzheimer's clinical samples at a low cost in comparison with the MRI-CNN images model at the early stage and get a good indicator for high classification rate for MRI images when applying our proposed model of SHC.

Preprint REVIEW | doi:10.20944/preprints201907.0265.v2

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

Melvin Hayden

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Aging; Alzheimer’s disease; brain insulin resistance; db/db diabetic mouse model; diabetic cognopathy; insulin resistance; metabolic syndrome; mixed dementia; obesity; type 2 diabetes mellitus

Online: 9 September 2019 (06:12:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0383.v1

Calabria as a Genetic Isolate, a Model for the Study of Neurodegenerative Diseases

Francesco Bruno, Valentina Laganà, Raffaele Di Lorenzo, Amalia Cecilia Bruni, Raffaele Maletta

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Calabria; Italy; neurodegenerative diseases; Alzheimer’s disease; Frontotemporal dementia; Par-kinson’s disease; Niemann Pick type C disease; Spino-cerebellar ataxia; Creutzfeldt–Jakob disease; Gerstmann Straussler Scheincker disease

Online: 22 August 2022 (11:23:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0470.v1

Mouse Ataxin-2 Expansion Downregulates CamKII and other Calcium Signaling Factors, Impairing Granule – Purkinje Neuron Synaptic Strength

Aleksandar Arsović, Melanie Vanessa Halbach, Julia Canet-Pons, Dilhan Esen-Sehir, Claudia Döring, Florian Freudenberg, Nicoletta Czechowska, Kay Seidel, Stephan L. Baader, Suzana Gispert, Nesli-Ece Sen, Georg Auburger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Amyotrophic Lateral Sclerosis (ALS); Fronto-Temporal-Lobar-Dementia; Tauopathies; synaptic plasticity; long-term potentiation; spatial learning; inositol signaling; neurexin; K-homology RNA-binding domain; Fragile-X-associated Tremor-Ataxia syndrome

Online: 21 August 2020 (04:39:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0176.v1

Psychometric Evaluation of the Depression Anxiety Stress Scale 8-items (DASS-8)/DASS-12/DASS-21 among Italian and Swiss Family Caregivers of Patients with Dementia

Amira Ali, Rana Ali Alameri, Amin Omar Hendawy, Rasmieh Al-Amer, Ghada Shahrour, Esraa M. Ali, Abdulmajeed A. Alkhamees, Nashwa Ibrahim, Bothaina Hussein Hassan

Subject: Social Sciences, Psychology Keywords: psychological distress/anxiety/depression; dementia; Alzheimer’s disease; Parkinson’s disease; short form of the Depression Anxiety Stress Scale 21; Depression Anxiety Stress Scale 8-items; factor structure; psychometric properties; structural validity; validation; measurement invariance; old age/elders/elderly; informal; family caregivers; spouse; adult children

Online: 9 August 2022 (08:44:11 CEST)

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