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Preprint ARTICLE | doi:10.20944/preprints202310.0971.v1

Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease

Amanda Fortes Francisco, Giovane R. Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, John M. Kelly

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; electrocardiography (ECG); Chronic Chagas Cardiomyopathy; Chagas heart disease

Online: 16 October 2023 (12:36:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1198.v1

Pirfenidone Prevents the Onset of Heart Fibrosis during Chronic Chagas Disease Cardiomyopathy

Tatiana Araújo Silva, Diane Thomas, Jair Lage Siqueira-Neto, Claudia Magalhaes Calvet

Subject: Biology And Life Sciences, Parasitology Keywords: Heart fibrosis; Chagas disease; Pirfenidone

Online: 20 November 2023 (07:34:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0460.v1

Proof-of-Concept of a Novel Multiepitope Recombinant Protein for the Serodiagnosis of Patients with Chagas Disease

Juliana Martins Machado, Isabela Amorim Gonçalves Pereira, Ana Clara Gontijo Maia, Mariana Ferraz Chaves Francisco, Lais Moreira Nogueira, Isadora Braga Gandra, Anna Julia Ribeiro, Kamila Alves Silva, Carlos Ananias Aparecido Resende, Jonatas Oliveira da Silva, Michelli dos Santos, Ana Alice Maia Gonçalves, Grasiele de Sousa Vieira Tavares, Miguel Angel Chávez-Fumagalli, Mariana Campos da Paz da Paz, Rodolfo Cordeiro Giunchetti, Manoel Otávio C. Rocha, Ana Thereza Chaves, Eduardo Antônio Ferraz Coelho, Alexsandro S. Galdino

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: multiepitope; recombinant protein; immunodiagnosis; Chagas disease

Online: 26 December 2022 (02:17:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0829.v1

Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy

Frédéric Gallardo, Pauline Brochet Brochet P, David Goudenège, João Paulo Silva Nunes, Pauline Andrieux, Barbara Maria Ianni, Amanda Farage Frade, Charles Mady, Ronaldo Honorato Barros Santos, Andreia Kuramoto, Samuel Steffen, Antonio Noedir Stolf, Pablo Pomerantzeff, Alfredo Inacio Fiorelli, Edimar Alcides Bocchi, Cristina Wide Pissetti, Bruno Saba, Fabrício Dias, Marcelo Ferraz Sampaio, Fabio Antônio Gaiotto, José Antonio Marin-Neto, Abílio Fragata, Ricardo Costa Fernandes Zaniratto, Sergio Siqueira, Giselle De Lima Peixoto, Fernando Bacal, Paula Buck, Rafael Ribeiro Almeida, Hui Tzu Lin-Wang, André Schmidt, Mario Hiroyuki Hirata, Eduardo Antonio Donadi, Alexandre Costa Pereira, Virmondes Rodrigues Junior, Martino Martinelli, Michel Naslavsky, Jorge Kalil, Vincent Procaccio, Edecio Cunha-Neto, Christophe Chevillard

Subject: Biology And Life Sciences, Parasitology Keywords: chagas; cardiomyopathy; mitochondria; haplgroups; variants; copy-number

Online: 13 October 2023 (03:03:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1620.v1

The Therapeutic Potential of Angeli’s Salt in Mitigating Acute Trypanosoma Cruzi Infection in Mice

Vera Lúcia Hideko Tatakihara, Aparecida Donizette Malvezi, Rito Santo Pereira, Bruno Fernando Cruz Lucchetti, Lucas Felipe Dos Santos, Rubens Cecchini, Lucy Megumi Yamauchi, Sueli Fumie Yamada-Ogatta, Katrina M Miranda, Waldiceu Aparecido Verri Jr, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chagas disease; Therapy; Nitroxyl; Leukopenia; Thrombocytopenia; Oxidative stress; Macrophages

Online: 22 June 2023 (12:17:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0054.v1

The Elusive Trypanosoma cruzi Disperse Gene Protein Family (DGF-1)

Jose Luis Ramirez

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chagas Disease; surface proteins; disperse protein family; Trypanosoma cruzi

Online: 3 February 2023 (03:11:08 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints201910.0166.v1

In Vitro Benznidazole and Nifurtimox Susceptibility Profile of Trypanosoma cruzi Strains Belonging to Discrete Typing Units TcI, TcII and TcV

Suzana Revollo, Bruno Oury, Andrea Vela, Michel Tibayrenc, Denis Sereno

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chagas Disease; Trypanosoma cruzi; benznidazole; nifurtimox; antimicrobial susceptibility test

Online: 15 October 2019 (08:26:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0380.v1

Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?

Bianca Zingales, Andréa M Macedo

Subject: Biology And Life Sciences, Other Keywords: Trypanosoma cruzi; Discrete Typing Units; genomics; Chagas disease manifestations; ecoepidemiology

Online: 7 November 2023 (11:40:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202303.0409.v1

Out-of-Pocket Costs Related to Chagas Disease: The Experience in Endemic Municipalities in Colombia

Rafael Herazo, Adriana Rey, Diogo Galvao, Manuel Medina Camargo, Nini Johana Cobos Pinzón, Alba Cecilia Rodriguez Sanchez, Andrea Marchiol, María Jesus Pinazo

Subject: Public Health And Healthcare, Health Policy And Services Keywords: out-of-pocket cost; primary healthcare; specialized reference hospital; Chagas

Online: 23 March 2023 (04:29:57 CET)

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Background Out-of-pocket costs are key expenses that many individuals incur in order to receive health services. They have been identified as a key access barrier for vulnerable populations, in particular for populations affected by neglected diseases with a chronic progression, such as Chagas disease. It is important to understand the costs of accessing healthcare services that are borne by patients with T. cruzi infection. Methodology We prepared a structured survey for patients with T. cruzi infection/Chagas disease who were all treated by the healthcare system in endemic municipalities in Colombia. The results were analyzed according to three categories: 1. the socioeconomic profiling of the patients; 2. the costs of and time spent on transportation; and 3. the opportunity costs (money that was not earned) related to treatment at the local primary care hospital or at the high-complexity reference hospital. Main findings Ninety-one patients answered the survey voluntarily. The data revealed that, when treated at the specialized reference hospital, patients spent 5.5 times more on food and accommodation, transportation costs were five times higher, and the loss of earnings was three times higher than when they were treated at the local primary care hospital. Moreover, the amount of time spent on transportation was 4 times higher at the reference hospital. Conclusions Providing comprehensive healthcare services for Chagas management at local primary healthcare hospitals would allow the most vulnerable patients to save on expenses related to medical and non-medical costs (out-of-pocket costs), in turn leading to higher adhesion to treatment thus benefiting the health system as a whole. These findings are in alignment with the WHO’s World Health Assembly 2010 Resolution on the importance of treating Chagas at local primary care hospitals, thereby saving patients time and money, allowing for timely care, and promoting access to healthcare.

Preprint ARTICLE | doi:10.20944/preprints201808.0059.v1

Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model

Janeesh A. Plakkal, Kezia Lizardo, Sean Wang, Edward Yurkow, Jyothi F. Nagajyothi

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chagas disease; cardiomyopathy; mitochondrial stress; endoplasmic reticulum stress; 2-aminopurine

Online: 3 August 2018 (04:36:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1348.v1

Examining the Impact of Infection Reactivation on Extracellular Vesicles purified from Patients with Chronic Chagas Disease

Rafael Pedro Madeira, Paula Meneghetti, Nicholy Lozano, Gislene M. Namiyama, Vera Lucia Pereira-Chioccola, Ana Claudia Torrecilhas

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; extracellular vesicles; chronic Chagas Disease patients; immunosuppression; infection reactivation.

Online: 18 December 2023 (15:17:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0244.v1

The Cost of Lost Productivity due to Premature Chagas Disease-Related Mortality: Evidence from Colombia (2010-2017)

Mario J. Olivera, Francisco Palencia-Sánchez, Martha Riaño-Casallas

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Chagas disease; cost of illness; mortality premature; efficiency; organizational; life expectancy

Online: 15 April 2020 (10:18:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0213.v1

Serum from Laron Mice Partially Protects against Trypanosoma Cruzi Infection

Patricia Mora-Criollo, Reetobrata Basu, Yanrong Qian, Kevin Funk, Stephen Bell, Jonathan Young, Jaime A. Costales, Jaime Guevara-Aguirre, Mario J. Grijalva, John J. Kopchick

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: Chagas Disease; Laron Syndrome; Growth Hormone; Trypanosoma cruzi; GHR-/- mice; bGH mice

Online: 13 December 2022 (01:15:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1176.v1

Unmasking the Mechanism behind Miltefosine: Revealing the Disruption of Intracellular Ca2+ Homeostasis as a Rational Therapeutic Target in Leishmaniasis and Chagas Disease

Gustavo Benaim, Alberto Paniz-Mondolfi

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Ca2+ signaling; Ca2+ regulation; miltefosine; acidocalcisome; mitochondria; Ca2+ Channel; sphingosine; Chagas Disease; Leishmaniasis

Online: 21 February 2024 (04:22:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0243.v1

Echocardiographic Documentation of Dilated Cardiomyopathy Development in Dogs Naturally Infected with Trypanosoma cruzi

Eduardo E. Avalos-Borges, Carlos Manuel Acevedo-Arcique, Jose Candelario Segura-Correa, Matilde Jimenez-Coello, Nisha Jain Garg, Antonio Ortega-Pacheco

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Echocardiographic alterations; left ventricle; dog; Trypanosoma cruzi; flow patterns; dilated car-diomyopathy; Chagas disease

Online: 3 April 2024 (16:03:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1321.v1

Examining Natural Products with the Potential to Chagas Disease: An In-depth Analysis

Eze Elijah Ajaegbu, Chizurum Philip Ikegbuna

Subject: Medicine And Pharmacology, Pharmacy Keywords: Chagas disease; Trypanosoma cruzi; Natural products; Therapeutic approaches; Anti-parasitic compounds; Plant-derived compounds

Online: 17 January 2024 (12:04:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0207.v1

The Potential Use of Peptides in the Fight against Chagas Disease and Leishmaniasis

Nir Qvit, Mulate Zerihun, Mahesh Kumar, Hayelom Berhe

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Neglected tropic diseases; Parasites; Chagas disease; Leishmaniasis; Life cycle; Drug target; Biochemical mechanisms; Pharmacological therapeutics; Peptides

Online: 6 September 2023 (14:52:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0325.v1

Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis

Denis Sereno, Mohammad Akhoundi, Kourosh Sayehmri, Asad Mizraei, Philippe Holzmuller, Veerle Lejon, Etienne Waleckx

Subject: Biology And Life Sciences, Parasitology Keywords: Leishmaniases; Chagas disease; Human African Trypanosomiasis; Animal trypanosomiasis; Diagnosis; non-invasive; Meta-analysis; Vector Born diseases; Neglected tropical disease; Diagnosis

Online: 23 February 2020 (13:44:05 CET)

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Unicellular eukaryotes of the Trypanosomatidae family include human and animal pathogens that belong to the Trypanosoma and Leishmania genera. Diagnosis of the diseases they caused requires the sampling of body fluids (blood, lymph, peritoneal fluid, cerebrospinal fluid, etc.) or organ biopsies (bone marrow, spleen, etc.), which are mostly obtained through invasive methods. Body fluids or appendages can be alternatives to these invasive biopsies but appropriateness remains poorly studied. To further address this question, we perform a systematic review on clues evidencing the presence of parasites, genetic material, antibodies, and antigens in body secretions, appendages, or the organs or proximal tissues that produce these materials. Paper selection was based on searches in PubMed, Web of Science, WorldWideScience, SciELO, Embase, Google. The information of each selected article (n=333) was classified into different sections and data were extracted from 77 papers. The presence of Trypanosomatidae parasites has been tracked in most of organs or proximal tissues that produce body secretions or appendages, in naturally or experimentally infected hosts. The meta-analysis highlights the paucity of studies on Human African Trypanosomiasis and a the absence on animal Trypanosomiasis. Among the collected data high heterogeneity in terms of the I² statistic (100%) is recorded. A high positivity is recorded for antibody and genetic material detection in urine of patients and dogs suffering leishmaniasis, and of antigen for leishmaniasis and Chagas disease. Data on conjunctival swab can be analyzed with molecular methods solely for dogs suffering canine visceral leishmaniasis. Saliva and hair/bristle showed a pretty good positivity that support their potential to be used for leishmaniasis diagnosis. In conclusion, our study pinpoints significant gaps that need to be filled in order to properly address the interest of body secretion and hair or bristle for the diagnosis of infections caused by Leishmania and by other Trypanosomatidae parasites.

Preprint REVIEW | doi:10.20944/preprints202401.2167.v1

Immune Reactions of Vector Insects to Parasites and Pathogens

Norman Arthur Ratcliffe, Cicero Brasileiro Mello, Helena Carla Castro, Paul Dyson, Marcela Figueiredo

Subject: Biology And Life Sciences, Parasitology Keywords: insect vector immunity; Anopheles; Aedes; Culex; blackflies; sandflies; tsetse flies; lice; fleas; Rhodnius; mosquitoes; malaria; sleeping sickness; leishmaniasis; Chagas disease; filariasis; onchocer

Online: 31 January 2024 (05:58:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1981.v1

Low-salt Diet Regulates the Metabolic and Signal Transduc-tion Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways

Dumitru A. Iacobas, Haile Allen, Sanda Iacobas

Subject: Biology And Life Sciences, Life Sciences Keywords: Adrenergic signaling in cardiomyocytes; cardiac muscle contraction; Chagas disease; diabetic car-diomyopathy; dilated cardiomyopathy; glycerolipid metabolism; glycolisis/glucogenesis; hyper-trophic cardiomyopathy; purine metabolism; steroid hormone biosynthesis

Online: 29 January 2024 (08:48:50 CET)

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