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Preprint ARTICLE | doi:10.20944/preprints202010.0125.v1

Critical Care Transfers and COVID-19: Managing Capacity Challenges through Critical Care Networks

Eleanor Pett, Hai Lin Leung, Emily Taylor, Martin Shao Foong Chong, Teddy Tun Win Hla, Giulia Sartori, Vivian Sathianathan, Tariq Husain, Ganesh Suntharalingam, Alexander Rosenberg, Angela Walsh, Timothy Wigmore

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Critical Care Capacity; Critical Care Transfers; Critical Care Networks; COVID-19 Critical Care Capacity; COVID-19; Patient Transfer; Inter-hospital transfer; COVID-19, SARS-CoV-2

Online: 6 October 2020 (11:41:35 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.0753.v1

Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases

Motohiro Kimata, Kenichi Hashimoto, Naomi Harada, Yusuke Kawamura, Yoshifumi Kimizuka, Yuji Fujikura, Mayuko Kaneko, Nobuaki Kiriu, Yasumasa Sekine, Natsumi Iwabuchi, Tetsuro Kiyozumi, Akihiko Kawana, Susumu Matukuma, Yuji Tanaka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: ambulatory electrocardiographic markers; coronavirus disease-19; COVID-19; global cardiac ischemia; Holter electrocardiograph; myocardial remodeling; SARS-CoV-2; sudden cardiac death

Online: 13 March 2024 (07:31:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0348.v1

Accuracy of Anti-SARS-CoV2 Antibody in Comparison with Surrogate Viral Neutralization Test in Person Living with HIV, Systemic Lupus Erythematosus and Chronic Kidney Disease

Marita Restie Tiara, Chrisan Bimo Prayuda, Tara Titian Maulidya, Hofiya Djauhari, Dadang Suhendar, Rudi Wisaksana, Laniyati Hamijoyo, Rudi Supriyadi, Agnes Rengga Indrati, Bachti Alisjahbana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; vaccination; antibody; immunoassay; neutralization antibody

Online: 4 April 2024 (05:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0095.v1

Beyond Information Provision: A Critical Analysis of the Roles of Structure and Agency in Decision-Making about COVID-19 Vaccination in ETHNIC minority Communities and Recommendations for Primary Care

Shoba Poduval, Atiya Kamal, Sam Martin, Amin Islam, Chandrika Kaviraj, Paramjit Gill

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Ethnic and Racial Minorities; Ethnicity; Covid-19; Covid-19 Vaccines; Vaccination Hesitancy; Health Inequities; Primary Health Care; Public Health; Health Promotion; Systemic Racism

Online: 3 July 2023 (13:55:22 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202004.0210.v1

An Alternative to Ventilators to Support Critical COVID-19 Patients

Gang Pan, Tao Lyu, John Hunt

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; oxygen nanobubble; intravenous therapy; ventilator

Online: 13 April 2020 (10:53:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0066.v1

The Role of Rotational Thromboelastometry (ROTEM) in Understanding the Coagulation Problems in COVID-19 Associated Critical Illness

Natalie Duric, Tamas Szakmany

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: ROTEM; COVID-19; coagulation

Online: 1 February 2021 (17:34:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0913.v1

Elevated Methaemoglobin Level in COVID-19 Patients at Intensive Care Unit

Zaid Khalid, Zoltán Vajda, Barna Vásárhelyi

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: COVID-19,methaemoglobin level; transfusion; mortality

Online: 13 June 2023 (09:32:04 CEST)

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Background : Our objectives were to investigate the incidence of elevated methemoglobin level among COVID-19 patients at intensive care unit. The correlation of methaemoglobinemia with mortality and some haematological parameters was also tested. Methods: The diagosis of coronavirus -19 infection was confirmed by RT-PCR. The quantitative method for determination of methemoglobin was it’s cyanide derivative by spectrophotometry. The reference range was less than 2 percent. Results: There were altogether 46 patients (11 male, 35 female) included. Their median age value was 70 y. ( 29 – 89). The methemoglobin median value was 4,3%. 15 of 46 patients died. The methemoglobin median value of departed patients was 8 % , and 2,5% was among survivors. ( P= 0,001) 19 patients were blood transfused. Their methemoglobin median was 11 % , otherwise the non transfused patients presented 2,7 % methemoglobin median. ( p= 0,001). We performed two binary logistic regression calculation, in order to judge the elevated methemoglobin level as an independent risk factor for the mortality. The predictor of methaemoglobin was 0,062 the constant -1,266 the odds ratio 1,06. The other binary logistic regression tested the fact of transfusion for the mortality. Predictor of transfusion 1,1474, constant -1,2527 odds ratio 3,15 There was no significant correlation between methemoglobin and CRP level. Discussion: The methemoglobin is not able to transport oxygen. It’s association with mortality is discussed by some papers.There are several hypothesis in the literature to explain it’s occurrence in COVID-19. The role of coronavirus proteins as oxydative agents was mentioned. The importance of enzyme defect is emphasized. The impact of reactive oxygen free radicals in inflammation is also probable. Some papers mentioned applying local anesthetics and azythromycin as a risk. The role of transfusion is obscure, because the methemoglobin can be elevated in blood conserves during storage. Conclusion: Testing the methemoglobin seems to be important, but the pathomechanism needs further research.. The traceability and standardization of different measurement methods at intensive care units is the key for defining it’s pathogenetic role.

Preprint ARTICLE | doi:10.20944/preprints202312.0240.v1

Antibiotic Use in Primary Care in Northern Ireland

Heather Coleman, Naomi Hadnett

Subject: Medicine And Pharmacology, Pharmacy Keywords: Antimicrobial use; antimicrobial resistance; COVID-19; pharmacists; primary care

Online: 5 December 2023 (14:52:26 CET)

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Research is scarce regarding antimicrobial use and antimicrobial resistance (AMR) for specific localities in Northern Ireland (NI). Additionally, the effects of COVID-19 on antimicrobial pre-scribing patterns and AMR are unknown. Between the European Union (EU) and United States (US), AMR causes approximately 68,000 deaths annually. This study will provide a better understanding of antimicrobial use and prescribing patterns in Belfast and link with AMR. An electronic survey was developed and distributed to eighty-five community pharmacists in Belfast. Yearly and monthly prescription data was gathered from the Business Services Organisation and COVID-19 statistics from Gov.uk. All data was analysed on Microsoft Office Excel® and IBM® SPSS® Statistics 25. Overall response rate was 46%. Most pharmacists (82%) failed to address prescriber non-compliance with guidelines and antimicrobial dosing errors (59%). The most common in-dication for antibiotics was upper respiratory tract infections (URTIs). Overprescribing of anti-biotics was perceived as the leading cause of AMR, therefore 69% of pharmacists indicated in-creased General Practitioner (GP) compliance with guidelines would reduce AMR. Pharmacists’ are in an ideal position to reduce AMR through patient education however, it is demonstrated that pharmacists failed to adequately counsel patients on antibiotic use. All GP practices demonstrated inappropriate antibiotic use, especially for URTIs which suggests antibiotic appropriateness should be reviewed. Many patients avoided contact with GP’s during COVID-19 which may have resulted in reduced antibiotic use. This research established amoxicillin as the most commonly prescribed antibiotic, which is contributing to increased AMR with its broad-spectrum activity and has recognised a decrease in antibiotic prescribing during COVID-19. Based on the results found and a critical review of the literature it is recommended antimicrobial guidelines should be re-viewed and improved, enhanced training should be provided to pharmacists and the antibiotic guardian (AG) campaign should be reenergised.

Preprint ARTICLE | doi:10.20944/preprints202402.0892.v1

Blood Biomarkers Show Neural Consequences of LongCOVID-19

Norina Tang, Tatsuo Kido, Jian Shi, Erin McCafferty, Judith M. Ford, Kaitlyn Dal Bon, Lynn Pulliam

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: LongCOVID-19; biomarkers; neuronal extracellular vesicles; BDNF; cortisol; cognition

Online: 16 February 2024 (07:02:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0559.v1

Depression, Anxiety and Stress among Health Care Professionals on Duty in COVID-19 Wards

Maham Noor Afroz, Syeda Maria Hassan, Kanwal Bansari, Humza Faisal Siddiqui, Sana Irfan, Basma Ali, Hamza Sohail, Zoha Batool, Muhammad Khizar Memon, Sidra Memon, Faizan Shaukat

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Stress; Anxiety; Depression; HCPs; COVID-19

Online: 27 October 2020 (15:27:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0311.v1

Pre- and Post-COVID-19 Antimicrobial Resistance Pattern of Pathogens in an Intensive Care Unit

Andreea-Loredana Golli, Ovidiu Zlatian, Monica Laura Cara, Mădălina Olteanu

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: antimicrobial resistance; COVID-19; pandemic; pathogens

Online: 6 February 2024 (09:17:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0533.v2

Prospects of Nutritional Interventions in the Care of COVID-19 Patients

Sabiha Alam, Farhana Rumzum Bhuiyan, Tanvir Hossain Emon, Mahmudul Hasan

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Macronutrients; Micronutrients; COVID-19; SARS-CoV-2; Immunity; Complications;

Online: 26 October 2020 (11:26:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0801.v1

The Cornell COVID-19 Testing Laboratory: A Model to High-Capacity Testing Hubs for Infectious Disease Emergency Response and Preparedness

Melissa Laverack, Rebecca Tallmadge, Roopa Venugopalan, Daniel Sheehan, Scott Ross, Rahim Rustamov, Kim S Potter, Francois Elvinger, Lorin D. Warnick, Gary A. Koretzky, Casey Frederici, Rob Lawlis, Elizabeth Plocharczyk, Diego G Diel

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; SARS-CoV-2; diagnostic workflow; surveillance

Online: 12 June 2023 (08:44:37 CEST)

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Working Paper CASE REPORT

Clinical Pathology of Critical Patient with Novel Coronavirus Pneumonia (COVID-19)

Weiren Luo, Hong Yu, Jizhou Gou, Xiaoxing Li, Yan Sun, Jinxiu Li, Lei Liu

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Novel coronavirus pneumonia; COVID-19; SARS-CoV-2; Pathology; Critical patient

Online: 9 March 2020 (10:31:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0296.v1

Managing Care during the COVID-19 Pandemic: The Point of View and Fears of Pediatric Cancer Patients’ Families

Olga Nigro, Giovanna Sironi, Andrea Ferrari, Gabriele Tinè, Gabriele Infante, Francesco Barretta, Matteo Silva, Carlo Alfredo Clerici, Stefano Chiaravalli, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Cristina Meazza, Filippo Spreafico, Michela Casanova, Monica Terenziani, Roberto Luksch, Maura Massimino

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; pediatric cancer; managing care

Online: 23 February 2022 (13:57:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0446.v1

Point-of-Care Testing, Spatial Care Paths, and Enhanced Standards of Care – Preparing Island Communities for Global Warming and Rising Oceans

Gerald Kost, Anna Fuzery, Louie Caratao, Samantha Tinsay, Amanullah Zadran, Adrian Ybanez

Subject: Public Health And Healthcare, Nursing Keywords: acute myocardial infarction; coronavirus disease 2019 (COVID-19); island communities; point-of-care testing; spatial care paths

Online: 28 October 2022 (09:30:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0330.v1

Predicting Intensive Care Unit Admission of COVID-19 Patients with Open Data: Analysis of the First Wave in Colombia

Ruben Acosta-Velasquez, William Fajardo-Moreno, Leonardo Espinosa-Leal

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Covid-19; machine learnin; , ICU; admission

Online: 19 December 2022 (08:42:28 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202211.0497.v2

Avoidable Intensive Care Resource Use of Unvaccinated COVID-19 Patients: Interpretation and Policy Implications

Ari Joffe, Chris Milburn

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; intensive care unit; policy; resource use; vaccination

Online: 18 April 2023 (11:02:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0433.v1

Risk Factors for Mortality of Adult Patients With COVID-19: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico

Carlos Axel López Pérez, Francisco Javier Santa Cruz Pavlovich, Juan Eduardo Montiel Cortés, Adriana Nuñez Muratalla, Ruth Bibani Morán González, Ricardo Villanueva Gaona, Xochitl Franco Mojica, Denisse Gabriela Moreno Sandoval, Joselyn Anacaren González Bañuelos, Alan Ulises López Pérez, Marily Flores González, Cristina Grijalva Ruiz, Edna Daniela Valdez Mendoza, Luis Renee González Lucano, Martín López Zendejas

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; Cohort; Mortality; Mexico

Online: 24 January 2023 (13:21:09 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0334.v1

Molnupiravir Revisited—Critical Assessment of Studies in Animal Models of COVID-19

Henrik Berg Rasmussen, And Peter Riis Hansen

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: molnupiravir; COVID-19; antiviral efficacy; animal models; animal-to-human extrapolation

Online: 6 September 2023 (05:07:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0870.v1

Post-COVID-19 Condition Patients’ Utilisation of Healthcare Resources after Implementation of an Integrated Care Unit: A Retrospective and Case-Control Observational Study

José Ángel Vicente Nieto, Martín de Muniategui Climent, Cora Loste, Saúl Barreales, Laura Ricou Ríos, Roger Paredes, Lourdes Mateu, Francesc Lopez Segui

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Economic evaluation; Healthcare utilisation; Post-COVID-19 condition; Long COVID

Online: 16 February 2024 (11:34:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0264.v1

The Coagulation Profile Monitoring of COVID-19 Patients with Standard and Viscoelastic Point of Care Hemostasis Tests

Milan Lazarević, Natalija Vuković, Dragan Milic, Aleksandar Kamenov, Velimir Peric, Mladan Golubovic, Dimitrije Spasic, Vladimir Stojiljkovic, Marija Stosic, Dragana Stokanovic

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID 19; coagulation; viscoelastic tests; thrombosis; mortality

Online: 5 June 2023 (08:15:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1804.v1

Interprofessional Collaboration in Primary Care Practices during the COVID-19 Pandemic In Switzerland

Fatima El hakmaoui, Muriel Schuetz, Renzo Scuderi, Nicolas Senn, Christine Cohidon

Subject: Public Health And Healthcare, Primary Health Care Keywords: primary care; nurses; public health; interprofessionnal collaboration; covid-19

Online: 25 January 2024 (07:12:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0417.v1

Acute Care Physiotherapy Management of COVID-19 Patients in Qatar: Best Practice Recommendations

Ajimsha MS, Neeraj Gampawar, Praveen Surendran, Prasobh Jacob, Vasileios Karpouzis, Mohamed Haneef, Muhamed Aleef, Shameem Ali, Reshma Praveen, Eladel Bouguerra, Noora Almudahka

Subject: Public Health And Healthcare, Nursing Keywords: Coronavirus; COVID-19; SARS-Cov-2; infection; Physiotherapy; rehabilitation

Online: 23 April 2020 (15:22:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0060.v1

COVID-19 in Care Homes: Atypical Presentations and High Mortality Rates Mean Outbreak Management Needs to Include Health and Social Care - Early Identification of Atypical Clinical Signs, and Complete Segregation of Cases, Not Cohorting, Is Essential

Anna Down, Arjun Dhillon, Graham Stretch

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; care homes; general practice; hospital discharges

Online: 7 June 2020 (05:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0687.v1

Impact of COVID-19 on the Care of Patients With HIV Infection

Marta Rosas Cancio-Suárez, Celia Alonso, María Jesús Vivancos, María Jesús Pérez-Elías, Javier Martínez-Sanz, María José Cárdenas, Manuel Vélez-Díaz-Pallarés, María Dolores Corbacho, Laura Martín-Pedraza, Alfonso Muriel, Santiago Moreno

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: SARS-CoV-2; HIV; COVID-19 pandemic; holistic care; PLWH

Online: 21 April 2023 (08:29:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0357.v1

Overview of Trans-National Recommendations for COVID-19 Transmission Control in Dental Care Settings

Mohamed Jamal, Maanas Shah, Sameeha Husain Almarzooqi, Hend Aber, Summayah Khawaja, Rashid El Abed, Zuhair Alkhatib, Lakshman Perera Samaranayake

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: coronavirus; COVID-19; SARS-CoV2; dentistry; oral health; transmission

Online: 20 April 2020 (02:14:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1463.v1

Quantification of hs-Troponin Level and Global Longitudinal Strain among Critical COVID-19 Patients with Myocardial Involvement

Mochamad Yusuf Alsagaff, Louisa Fadjri Kusuma Wardhani, Ricardo Adrian Nugraha, Tony Santoso Putra, Bagus Putra Dharma Khrisna, Makhyan Jibril Al-Farabi, Ruth Irena Gunadi, Yusuf Azmi, Christian Pramudita Budianto, Rosi Amrilla Fagi, Nadya Luthfah, Agus Subagjo, Yudi Her Oktaviono, Achmad Lefi, Budi Baktijasa Dharmadjati, Budi Susetyo Pikir, Firas Farisi Alkaff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; hs-Troponin; global longitudinal strain; intubation; myocarditis

Online: 24 October 2023 (07:51:05 CEST)

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Myocardial involvement among critical patients with coronavirus disease 2019 (COVID-19) has a worse outcome. The occurrence of an imbalance in oxygen supply results in the release of pro-inflammatory cytokines which leads to increased ventilation support requirement and increase risk of mortality. Our aim was to evaluate the association between hs-Troponin I level and global longitudinal strain as evidence of myocardial involvement among critical COVID-19 patients. Methods. We performed prospective cohort study from February 1st – July 31st, 2021 at Dr. Soetomo General Hospital, Surabaya as referral center for COVID-19 care. Of the 65 critical COVID-19 included, 41 (63.1%) were men, with a median (interquartile range) age of 51.0 years (20.0-75.0).Subjects were recruited according to WHO criteria for severe COVID-19 and CDC criteria for myocarditis. All subjects recruited were examined using echocardiography to measure global longitudinal strain (GLS) and blood samples were taken to measure hs-Troponin. Subjects were then followed to assess their needs for mechanical ventilation and in-hospital mortality. Severe COVID-19 subjects with cardiac injury were associated with an increased need for intubation (78.5%) and an increased incidence of myocarditis (50.8%). There was an association between the use of intubation and the risk of mortality in patients (66.7% vs. 33.3%, p-value <0.001). Both reduced GLS and increased hs-troponin are associated with increased myocarditis (p-value <0.001 and 0.004 respectively). Reduced GLS is associated with higher mechanical ventilation needs (12.17 + 4.79 vs.15.65 + 4.90, p-value 0.02) and a higher mortality rate (11.36 + 4.64 vs. 14.74 + 4.82; p-value 0.005). Increased hs-troponin is associated with higher mechanical ventilation needs (25.33% vs. 3.56%, p-value 0.002) and a higher mortality rate (34.57% vs. 5.76%, p-value 0.002). Compared with contemporary controls, critical COVID-19 patients with myocardial involvement and elevated cardiac troponin level are associated with higher mechanical ventilation needs and a higher mortality rate.

Preprint BRIEF REPORT | doi:10.20944/preprints202308.2206.v1

Prevalence of Pneumocystis jirovecii Colonization in Non-critical Immunocompetent COVID-19 Patients: A Single Center Prospective Study

Antonio Riccardo Buonomo, Giulio Viceconte, Ludovica Fusco, Marina Sarno, Isabella Di Filippo, Luca Fanasca, Paola Salvatore, Ivan Gentile

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; Pneumocystis jirovecii; SARS-CoV-2; immunocompromised; pneumonia.

Online: 31 August 2023 (21:26:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0307.v1

The Impact of the COVID-19 Pandemic on Oncology Care and Clinical Trials

Jennyfa Kadiza Ali, John Charles Riches

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: SARS-Cov-2; COVID-19; oncology; cancer screening; clinical trials

Online: 21 October 2021 (12:45:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0488.v2

Comparison between Neutralization Capacity of Antibodies Elicited by COVID-19 Natural Infection and Vaccination in Indonesia: A Prospective Cohort

Sitti Nurisyah, Mitsuhiro Iyori, Ammar Abdurrahman Hasyim, Akihiko Sakamoto, Hinata Hashimoto, Kyouhei Yamagata, Saya Yamauchi, Khaeriah Amru, Kartika Hardianti Zainal, Irfan Idris, Shigeto Yoshida, Irawaty Djaharuddin, Din Syafruddin, Agussalim Bukhari, Puji Budi Setia Asih, Yenni Yusuf

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: COVID-19; Receptor binding domain (RBD); natural infection; vaccination; neutralizing antibodies

Online: 8 August 2023 (07:11:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0224.v2

Primary Series COVID-19 Vaccine Effectiveness among Health Care Workers in the Country of Georgia, March–December 2021

Mark A. Katz, Madelyn Yiseth Rojas Castro, Giorgi Chakhunashvili, Nazibrola Chitadze, Caleb Ward, C. Jason McKnight, Héloïse Lucaccioni, Iris Finci, Tamila Zardiashvili, Richard Pebody, Esther Kissling, Lia Sanodze

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: COVID-19; vaccine effectiveness; healthcare workers; Georgia; delta

Online: 7 October 2023 (03:27:13 CEST)

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Background Healthcare workers (HCWs) have suffered considerable morbidity and mortality during the COVID-19 pandemic. Few data on COVID-19 vaccine effectiveness (VE) are available from middle-income countries in Europe. We evaluated primary series COVID-19 VE against laboratory-confirmed COVID-19 among HCWs in Georgia. Methods HCWs in six hospitals in Georgia were invited to enroll in a prospective cohort study conducted during March 19–December 5, 2021. Participants completed weekly symptom questionnaires. Symptomatic HCWs were tested by RT-PCR and/or rapid antigen test (RAT), and participants were routinely tested for SARS-CoV-2 by RT-PCR or RAT, regardless of symptoms. Serology was collected at enrolment, and quarterly thereafter, and tested by electrochemiluminescence immunoassay for SARS-CoV-2 antibodies. We defined primary series vaccination as two doses of COVID-19 vaccine received ≥14 days before symptom onset. We estimated VE as (1-hazard ratio)*100 using a Cox proportional hazards model with vaccination status as a time-varying covariate. Estimates were adjusted by potential confounders that changed the VE estimate by more than 5%, according to the change-in-estimate approach. Results Overall, 1561/3849 (41%) eligible HCWs enrolled and were included in the analysis. The median age was 40 (IQR: 30-53), 1318 (84%) were female, and 1003 (64%) had laboratory evidence of prior SARS-Cov-2 infection. At enrolment, 1300 (83%) were unvaccinated; By study end, 1082 (62%) had completed a primary vaccine series (69% BNT162b2 (Pfizer-BioNTech); 22% BBIBP-CorV (Sinopharm); 9% other). During the study period, 191(12%) participants had a new PCR- or RAT-confirmed symptomatic SARS-CoV-2 infection. VEa gainst PCR- or RAT- confirmed symptomatic SARS-CoV-2 infection was 58 (95%CI: 41; 70) for all primary series vaccinations, 68% (95%CI: 51; 79) for BNT162b2, and 40% (95%CI: 1; 64) for BBIBP-CorV vaccines. Among previously infected HCWs, VE was 58% (95%CI: 11; 80). VE against medically attended COVID-19 was 52% (95%CI: 28; 68), and VE against hospitalization was 69% (95% CI: 36; 85). During the period of predominant Delta variant circulation (July-December 2021), VE against symptomatic COVID-19 was 52% (95%CI: 30; 66). Conclusions Primary series vaccination with BNT162b2 and BBIBP-CorV was effective at preventing COVID-19 among HCWs, most of whom had previous infection, during a period of mainly Delta circulation. Our results support the utility of COVID-19 primary vaccine series, and the importance of increasing coverage, even among previously infected individuals.

Preprint REVIEW | doi:10.20944/preprints202007.0568.v1

Peter Sherren, Marlies Ostermann, Sangita Agarwal, Chris Meadows, Nicholas Ioannou, Luigi Camporota

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: SARS-CoV-2; COVID-19; respiratory failure; ARDS; ventilation; MODS; ECMO

Online: 24 July 2020 (04:00:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1017.v1

Multidrug-Resistant ESKAPE Pathogens in a Romanian Secondary-Care Hospital during the COVID-19 Pandemic

Constantin- Marinel Vlase, Alina-Viorica Iancu, Claudia-Simona Stefan, Iulia Draghiev, Caterina-Nela Dumitru, Manuela Arbune

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: ESKAPE; COVID-19; antimicrobial resistance; multidrug resistant organisms; antibiotic stewardship.

Online: 14 December 2023 (09:27:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0267.v2

Trends in Intensive Care for Patients with COVID-19 in England, Wales and Northern Ireland

James C Doidge, Paul R Mouncey, Karen Thomas, Doug W Gould, Paloma Ferrando-Vivas, Manu Shankar-Hari, David A Harrison, Kathryn M Rowan

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: COVID-19; intensive care; trends; United Kingdom; mortality; mechanical ventilation

Online: 9 September 2020 (09:28:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202012.0684.v1

COVID-19 Point-of-Care Diagnostics that Satisfy Global Target Product Profiles

Abdi Ghaffari, Robyn Meurant, Ali Ardakani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: COVID-19; point-of-care diagnostic test; target product profile; clinical performance

Online: 28 December 2020 (11:14:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0583.v1

The Impact of COVID-19 on Multidisciplinary Care Delivery to Children with Cerebral Palsy and Other Neuromuscular Complex Chronic Conditions

Hillary Brenda Nguyen, Neha Mulpuri, Danielle Cook, Michael Greenberg, Wade Shrader, Ryan Sanborn, Kishore Mulpuri, Benjamin Shore

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: COVID-19; cerebral palsy; neuromuscular conditions; pediatrics; orthopedics

Online: 8 August 2023 (07:30:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0092.v1

Different Responses to Stress, Health Practices and Self-care during COVID-19 Lockdown: A Stratified Analysis

Elena Bermejo-Martins, Elkin O. Luis, Ainize Sarrionandia, Martín Martínez, María Sol Garcés, Edwin Y. Oliveros, Cristian Cortés, Maider Belintxon, Pablo Fernández-Berrocal

Subject: Social Sciences, Psychology Keywords: COVID-19; health practices; stress; self-care; cross-cultural study

Online: 2 February 2021 (15:09:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0948.v1

Prevention Is Better Than Care. Clinical and Economic Implications of Oral Antiviral Agents in COVID 19: A Prospective Study

F. Pietrantonio, F. Rosiello, M. Ruggeri, Marco Materazzo, Vincenzo Mirco La Fazia, Nicola Pierucci, Rosa Iodice, G. Granvillano, Lamberto mc Cicerchia, Massimo Maurici, Michela Delli castelli, Fabio Vinci, Angela Ciamei, Marise Sabato, Aurelio Sparta, Davide Acco, Luca Fortunato, Maria sofia Cattaruzza, Antonio Vinci, M. Lordi, Enrica Cipriano

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Molnupiravir; SARS-CoV-2; COVID-19; Nirmatrelvir; oral antiviral

Online: 11 August 2023 (13:23:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0616.v1

Impact of COVID-19 Pandemic on Mental Health of the General Population, Students, and Health Care Workers: A Review

Sabina Sankhi, Nirmal Raj Marasine

Subject: Social Sciences, Psychology Keywords: COVID-19 pandemic; general population; students; health care workers

Online: 25 July 2020 (17:31:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0728.v1

Burnout and Moral Distress among Health Care Personnel in the Decline of COVID-19 Pandemic

Maria Papatheodorou, Christos Nouris, Ioannis Styliadis, Theo Bargiotas, Dimitrios Mihail

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Moral Distress; Moral Distress Factors; Moral Injury; Burnout; Post-Covid-19

Online: 13 February 2024 (10:46:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0663.v1

Radiation Overuse in Intensive Care Units: A Cause for Concern

Chiara Zanon, Costanza Bini, Alessandro Toniolo, Tommaso Benetti, Emilio Quaia

Subject: Medicine And Pharmacology, Other Keywords: Radiological Imaging; Radiation exposure; ICU patients; COVID-19; Optimization strategies; Cancer risk; Cumulative Effective Dose

Online: 11 December 2023 (06:08:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0815.v1

The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population Switch toward IgG4 after Multiple Doses with the mRNA Pfizer-BioNTech Vaccine.

Ana M Espino, Albersy Armina-Rodriguez, Laura Alvarez, Carlimar Ocasio, Riseilly Ramos-Nieves, Esteban I Rodríguez-Martinó, Paola López-Marte, Esther A. Torres, Carlos A. Sariol

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Covid-19; IgG4; Switch class; ELISA; neutralizing antibody

Online: 10 January 2024 (11:06:22 CET)

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Working Paper REVIEW

A Critical Review of Disinfection Processes to Control SARS-CoV-2 Transmission in the Food Industry

Adrián Pedreira, Yeşim Taşkın, Míriam R. García

Subject: Biology And Life Sciences, Food Science And Technology Keywords: SARS-CoV-2; COVID-19 pandemic; food industry; disinfection trade-offs; one-health

Online: 15 December 2020 (12:58:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1045.v1

Long-Term Quality of Life after COVID-19 Infection: A Cross-Sectional Study of Health Care Workers

Antar Moussa, Ullerich Hansjoerg, Zaruchas Andreas, Meier Torsten, Diller Ricarda, Pannewick Ulrich, Dhayat A. Sameer

Subject: Public Health And Healthcare, Nursing Keywords: Long-term quality of life (QoL); COVID-19 pandemic; health care workers; post-COVID syndrome; WHOQOL-BREF

Online: 12 January 2024 (17:15:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1037.v1

Resilient Nurses, COVID-19 Care and Beyond: Longitudinal Study of Psychology, Values and Self-Actualization

Chris Adam-Bagley, Mahmoud Abubaker, Alice Sawyerr

Subject: Public Health And Healthcare, Nursing Keywords: Nursing Values; COVID-19; Nursing Stress; Burnout; PTSD; Hardy Personality; Self-Actualization

Online: 16 November 2023 (11:09:07 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202005.0143.v1

The Main Risk Factors for the Number of Serious or Critical Cases of Covid-19: How is the Health of Brazilians?

Haniel Fernandes

Subject: Biology And Life Sciences, Virology Keywords: Covid-19; Epidemiology; Chronic diseases; Serious or critical cases; Brazil; Coronavirus

Online: 8 May 2020 (12:33:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0707.v1

Existential Suffering in Palliative Care: An Existential Positive Psychology Perspective

Paul T. P. Wong, Timothy T. F. Yu

Subject: Social Sciences, Psychology Keywords: Palliative care; Meaning therapy; CALM therapy; COVID-19; Existential positive psychology; Good death; wellbeing; mature happiness; flourishing

Online: 30 July 2021 (14:27:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1168.v1

Self-Management Predicts PTSD Symptoms and Post-traumatic Growth among Older Adults in Residential Care Homes in the Wake of COVID-19 Pandemic

Ido Ziv, Dafna Caspi, Daniela Cojocaru

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: self-management; Covid-19; aging management; PTSD; PTG; anxiety

Online: 17 May 2023 (02:28:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0593.v2

Hospital Admissions From Care Homes in England During the COVID-19 Pandemic: A Retrospective, Cross-Sectional Analysis Using Linked Administrative Data

Fiona Grimm, Karen Hodgson, Richard Brine, Sarah R Deeny

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Hospital admissions; care homes; COVID-19; linked data; administrative data

Online: 25 May 2021 (10:33:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1083.v1

Burnout in Medical Specialists Redeployed to Emergency Care During the COVID-19 Pandemic

Carol Nash

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: burnout; medical specialists; COVID-19; emergency care; public health; coping strategies; Lazarus; interventions; patient care

Online: 16 April 2024 (17:04:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0239.v1

Long-Term Care Workers’ Experiences and Their Views About Support During the COVID-19 Pandemic: A Scoping Review

Sheila A. Boamah, Rachel Weldrick, Farinaz Havaei, Ahmed Irshad, Amy Hutchinson

Subject: Public Health And Healthcare, Nursing Keywords: long-term care; healthcare workers; mental health; moral distress; resilience; COVID-19

Online: 12 August 2022 (12:43:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0620.v2

Parks are Critical Urban Infrastructure: Perception and Use of Urban Green Spaces in NYC During COVID-19

Bianca Lopez, Christopher Kennedy, Timon McPhearson

Subject: Business, Economics And Management, Accounting And Taxation Keywords: Urban green space; COVID-19; urban parks; open space; New York City; urban infrastructure; equity

Online: 30 September 2020 (10:00:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0167.v1

Impact of Japan’s State of Emergency on Trends in Diabetes Care during the COVID-19 Pandemic: A Retrospective and Descriptive Study

Akira Minoura, Kouzou Murakami, Masaaki Matoba, Yoshinori Ito, Yumi Kamijo, Akatsuki Kokaze

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: COVID-19 pandemic; diabetes care; infection control; Japanese; state of emergency

Online: 9 November 2022 (02:18:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0369.v1

Cancer Screening and Treatment Delays During the COVID-19 Pandemic and the Role of Health Literacy in Care Re-Engagement: Findings from an NCI-Designated Comprehensive Cancer Center Sample

Jessica Keim-Malpass, Rick D. Vavolizza, Wendy F. Cohn, Erin M. Kennedy, Shayna L. Showalter

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Covid-19; health literacy; cancer screening; cancer care; cancer prevention

Online: 25 October 2022 (02:02:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1561.v1

The Outcome of Antibiotic Overuse before and during the COVID-19 Pandemic in a Tertiary Care Hospital in Oman

Nenad Pandak, Hilal Al Sidairi, Ibrahim Al-Zakwani, Zakariya Al Balushi, Shabnam Chhetri, Muna Ba'Omar, Sultan Al Lawati, Seif S S Al-Abri, Faryal Khamis

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: antibiotics; multidrug resistance; meropenem; vancomycin; ceftriaxone; pandemics; COVID-19; Candida auris; Oman; viral infections

Online: 22 September 2023 (11:44:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0078.v2

Real-Time Epidemiology and Acute Care Need Monitoring and Forecasting for COVID-19 via Bayesian Sequential Monte Carlo-leveraged Transmission Models

Xiaoyan Li, Vyom Patel, Lujie Duan, Jalen Mikuliak, Jenny Basran, Nathaniel Osgood

Subject: Computer Science And Mathematics, Information Systems Keywords: COVID-19; Particle Filtering; Machine Learning; Epidemiologic Modeling; Compartmental Model; Projection and Intervention

Online: 7 September 2023 (10:25:49 CEST)

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COVID-19 transmission models have conferred great value in informing public health understanding, planning, and response. However, the pandemic also demonstrated the infeasibility of basing public health decision-making on transmission models with pre-set assumptions. No matter how favourably evidenced when built, a model with fixed assumptions is challenged by numerous factors that are difficult to predict. Ongoing planning associated with rolling back and re-instituting measures, initiating surge planning, and issuing public health advisories can benefit from approaches that allow state estimates for transmission models to be continuously updated in light of unfolding time series. A model being continuously regrounded by empirical data in this way can provide a consistent, integrated depiction of the evolving underlying epidemiology and acute care demand, offer the ability to project forward such a depiction in a fashion suitable for triggering the deployment of acute care surge capacity or public health measures, support quantative evaluation of tradeoffs associated with prospective interventions in light of the latest estimates of the underlying epidemiology. We describe here the design, implementation and multi-year daily use for public health and clinical support decision-making of a particle filtered COVID-19 compartmental model, which served Canadian federal and provincial governments via regular reporting starting in June 2020. The use of the Bayesian Sequential Monte Carlo algorithm of Particle Filtering allows the model to be re-grounded daily and adapt to new trends within daily incoming data – including test volumes and positivity rates, endogenous and travel-related cases, hospital census and admissions flows, daily counts dose-specific vaccinations administered, measured concentration of SARS-CoV-2 in wastewater, and mortality. Important model outputs include estimates (via sampling) of the count of undiagnosed infectives, the count of individuals at different stages of the natural history of frankly and pauci-symptomatic infection, the current force of infection, effective reproductive number, and current and cumulative infection prevalence. Following a brief description of model design, we describe how the machine learning algorithm of particle filtering is used to continually reground estimates of dynamic model state, support probabilistic model projection of epidemiology and health system capacity utilization and service demand and probabilistically evaluate trade-offs between potential intervention scenarios. We further note aspects of model use in practice as an effective reporting tool in a manner that is parameterized by jurisdiction, including support of a scripting pipeline that permits a fully automated reporting pipeline other than security-restricted new data retrieval, including automated model deployment, data validity checks, and automatic post-scenario scripting and reporting. As demonstrated by this multi-year deployment of Bayesian machine learning algorithm of particle filtering to provide industrial-strength reporting to inform public health decision making across Canada, such methods offer strong support for evidence-based public health decision making informed by ever-current articulated transmission models whose probabilistic state and parameter estimates are continually regrounded by diverse data streams.

Preprint ARTICLE | doi:10.20944/preprints202105.0030.v1

Application of Telehealth in Prenatal Care During the COVID-19 Pandemic - A Cross-Sectional Survey of Polish Women

Dominik Jakubowski, Dorota Sys, Anna Kajdy, Roksana Lewandowska, Ewa Kwiatkowska, Aneta Cymbaluk-Płoska, Michał Rabijewski, Andrzej Torbé, Sebastian Kwiatkowski

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; COVID-19; Prenatal Care; Standard of Care; Telemedicine; Cross-Sectional Studies; Poland

Online: 5 May 2021 (10:32:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0105.v1

Effectiveness of Intermediate Respiratory Care Units as An Alternative to Intensive Care Units During The Covid-19 Pandemic in Catalonia

Marina Galdeano Lozano, Julio Cesar Alfaro Alvarez, Nuria Parra Macías, Rosario Salas Campos, Sarah Heili Frades, Josep M. Montserrat, Antoni Rosell Gratacós, Jorge Abad Capta, Olga Parra Ordaz, Francesc Lopez Seguí

Subject: Biology And Life Sciences, Virology Keywords: respiratory care; covid; ICU; cost-effectiveness

Online: 12 April 2022 (08:49:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1643.v1

Vaccinating Against a Novel Pathogen: A Critical Review of COVID-19 Vaccine Effectiveness Evidence

Bernard Black, David B Thaw

Subject: Public Health And Healthcare, Health Policy And Services Keywords: COVID-19; SARS-CoV-2; vaccine; vaccine efficacy; vaccine effectiveness, vaccine booster; BNT162b2; mRNA1273; Ad26.COV2.S; ChAdOx1-S; SARS-CoV-2 variants

Online: 28 November 2023 (01:41:16 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202203.0370.v1

A Narrative of a Certified Nurse in Dementia Care in Japan How to Compensate the Gap Caused by Visitation Restrictions Due to Coronavirus Disease

Yuki Ohashi, Yumiko Furukubo, Diane Bunn

Subject: Public Health And Healthcare, Nursing Keywords: COVID-19; visitation restrictions; psychological distress; cognitive disfunction; long-term care; rehabilitation ward

Online: 28 March 2022 (15:13:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0024.v1

The Critical Issues for Patients and Caregivers in Neuro-Oncology During Covid-19 Pandemic: What We Have Learnt by an Observational Study.

Elena Anghileri, Irene Tramacere, Sara Morlino, Catia Leuzzi, Lorena Pereja Gutierrez, Saba Motta, Antonio Silvani, Francesca Romana Berrini

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Anxiety; Caregivers; Caregiver Burden; Communication; COVID-19; (Brain) Neoplasms; Pandemics; Perception; Psycho-Oncology; Quality of Life

Online: 1 April 2024 (10:08:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0087.v1

Understanding the Effect of COVID-19 Pandemic on Emergency Surgical Care Delivery in India: A Multicenter Cross-Sectional Study

Anita Gadgil, Geetu Bhandoria, Monty Khajanchi, Bhakti Sarang, Deepa K.V, Prashant Bhandarkar, Monali Mohan, Priyansh Shah, Lovenish Bains, Amulya Rattan, Naveen Sharma, Anurag Mishra, Devi Bavishi, Jaydip Hindocha, Sumit Arora, Ravi Kant, Dnyanesh Belekar, Randeep Wadhavan, Rajeev Satoskar, Ramlal Prajapati, Sudhir Shrivastava, Prashnat Kamble, Niranjan Maydeo, Ashish Gokhale, Nobhojit Roy

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: India; COVID-19 pandemic; Cancellation of surgeries; Global lockdown; Low- and Middle-income country; Emergency surgeries

Online: 5 October 2020 (13:02:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0422.v1

Effect of the COVID-19 Pandemic on Cost-Related Prescription Nonredemption, Health care Seeking and Hospitalization in Hungary: A Nationally Representative Cross-Sectional Study

Bayu Begashaw Bekele, Bahaa Aldin Alhaffar, Rahul Naresh Wasnik, János Sándor

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: CRPNR; COVID-19 pandemic; hospital admission; GP visit; Hungary; interaction effect; Roma; specialist care

Online: 27 December 2021 (11:05:43 CET)

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Background: Although, negative repercussions of inadequate health service use on the health outcomes has been presumably exacerbated by COVID-19, the impact of the pandemic measures has been not evaluated properly yet. Objective: Our study aimed to quantify the COVID-19 pandemic measures’ effect on the general practitioner (GP) visit, specialist care, hospitalization and cost-related prescription nonredemption (CRPNR) among adults in Hungary, and to identify the social strata susceptible to the pandemic effect. Methods: This community-based cross-sectional study based on nationally representative data of 6,611 (Nprepandemic=5,603 and Npandemic=1,008) subjects aged 18 years and above. Data were obtained from the European Health Interview Survey 2019 (EHIS) and International Social Survey Program 2021 (ISSP) for prepandemic and pandemic, respectively. Multivariable logistic regression models were applied to determine the sociodemographic and clinical factors influencing the health care use by odds ratios (OR) along with the corresponding 95% confidence intervals (CI). To identify the social strata susceptible to pandemic effect, the interaction of the time of data collection with level of education, marital status, and ethnicity, was also tested. Results: While, the CRPNR did not changed, the frequency of GP visit, specialist care and hospitalization rate were remarkably reduced by 22.2%, 26.4%, and 6.7%, respectively, during the pandemic in Hungary. Roma proved to be not specifically affected by the pandemic in any studied respect. The pandemic restructuring of health care impacted the social subgroups evenly with respect to hospital care. However, the pandemic effect was weaker among primary educated adults (ORhigh-school vs primary-education =0.434; 95% CI 0.243-0.776, ORhigh-school vs primary-education =0.598; 95% CI 0.364-0.985), and among widows (ORwidowed vs married =2.284; 95% CI 1.043-4.998, ORwidowed vs married=1.915; 95% CI 1.157-3.168) on the frequency of GP visit and specialist visit; and the prepandemic CRPNR inequality by level of education was increased (ORhigh-school vs primary-education =0.236; 95% CI 0.075-0.743). Conclusion: Primary educated and widowed did not follow the general trend, and their prepandemic limited health care use was not reduced further during pandemic, resulting in an inequality reduction. The vulnerability of primary educated to CRPNR was the only gap widened in the pandemic period. This shows that although the management of pandemic health care use restrictions was implemented by increasing the social inequality in Hungary, the prevention of inequity in drug availability for primary educated individuals could require more support.

Preprint ARTICLE | doi:10.20944/preprints202403.0973.v1

Length of Stay Analysis of COVID-19 Intensive Care Unit Admissions Using Count Regression and Hurdle Regression Models: A Study in a Tertiary Hospital, Cape Town, South Africa

Perseverence Savieri, Clemence Nyamandi, Lovemore N. Sigwadhi, Jacques Tamuzi, Brian Allwood, Coenraad F Koegelenberg, Elvis M Irusen, Usha Lalla, Veranyuy D Ngah, Annalise E Zemlin, Zivanai C Chapanduka, Rajiv T Erasmus, Tandi E Matsha, Justine O Daramola, Alimuddin Zumla, Peter Suwirakwenda Nyasulu

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: length of stay, COVID-19, ICU, generalized linear model, count regression, Hurdle model

Online: 18 March 2024 (07:17:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0195.v1

Capillary Leak Syndrome after SARS-CoV-2 Infection and COVID-19 Vaccines: A Comparative Review

Zeinab Mohseni Afshar, Hossein Nazari Rostami, Ali Tavakoli Pirzaman, Rezvan Hosseinzadeh, Arefeh Babazadeh, Dariush Hosseinzadeh, Seyed Rouhollah Miri, Terence T. Sio, Mohammad Barary, Soheil Ebrahimpour

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: COVID-19; COVID-19 vaccines; capillary leak syndrome

Online: 11 January 2023 (09:41:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0097.v1

Efficacy of COVID-19 Vaccines Against the Omicron Variant of SARS-CoV-2

Kritika Srinivasan Rajsri, Meena Singh, Mana Rao

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Bivalent COVID-19 vaccine; COVID-19 vaccination booster; COVID-19; Omicron; SARS-CoV-2

Online: 6 March 2023 (07:00:00 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202007.0526.v1

Confirmed and Unreported COVID-19 Death Counts: An Assessment of Reporting Discrepancy

Mazbahul G Ahamad, Fahian Tanin

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; Unreported COVID-19 Death; Provisional COVID-19 Death; Death Reporting Discrepancy; Bangladesh

Online: 22 July 2020 (11:32:05 CEST)

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Working Paper ARTICLE

Application of Tensor Decomposition to Gene Expression of Infection of Mouse Hepatitis Virus can Identify Critical Human Genes and Efffective Drugs for SARS-CoV-2 Infection

Y-H. Taguchi, Turki Turki

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: COVID-19; SARS-CoV-2; in silico drug discovery; gene expression profile; tensor decomposition; feature extraction

Online: 8 December 2020 (10:17:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0227.v1

Differences in the Course of depression and anxiety After COVID-19 Infection Between Recovered Patients With and Without a Psychiatric History: A Cross-Sectional Study

Megumi Hazumi, Kentaro Usuda, Emi Okazaki, Mayumi Kataoka, Daisuke Nishi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; depression; anxiety; post-acute COVID-19 syndrome; post-COVID

Online: 12 August 2022 (04:56:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0588.v1

Honors and Costs of Being Heroes: Risk Factors and Epidemiology of COVID-19 Infection among Health Care Workers of a Severely Hit COVID-19-Referral Hospital in Italy

Marta Colaneri, Viola Novelli, Sara Cutti, Alba Muzzi, Guido Resani, Cristina Monti, Claudia Rona, Anna Maria Grugnetti, Marco Rettani, Francesca Rovida, Valentina Zuccaro, Antonio Triarico, Carlo Marena

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: retrospective cohort study; COVID-19; SARS-CoV-2; health care workers; risk of infection

Online: 27 August 2020 (03:25:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0009.v1

Outcomes and Timing of Bedside Percutaneous Tracheostomy of COVID-19 Patients Over a Year in Intensive Care Unit

Nardi Tetaj, Micaela Maritti, Giulia Stazi, Maria Cristina Marini, Daniele Centanni, Gabriele Garotto, Ilaria Caravella, Cristina Dantimi, Matteo Fusetti, Carmen Santagata, Manuela Macchione, Giada De Angelis, Filippo Giansante, Donatella Busso, Rachele Di Lorenzo, Silvana Scarcia, Alessandro Carucci, Ricardo Cabas, Ilaria Gaviano, Nicola Petrosillo, Andrea Antinori, Fabrizio Palmieri, Gianpiero D'Offizi, Stefania Ianniello, Paolo Campioni, Francesco Pugliese, Francesco Vaia, Emanuele Nicastri, Giuseppe Ippolito, Luisa Marchioni

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Intensive care unit; percutaneous tracheostomy; COVID-19; early tracheostomy; late tracheostomy; ICU length of stay; health care workers; mechanical ventilation.

Online: 1 July 2021 (11:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0240.v1

Effects of Locomotion Regulatory Mode on COVID-19 Anxiety: The Mediating Role of Resilience

Calogero Lo Destro, Alberto Costa

Subject: Social Sciences, Psychology Keywords: Locomotion; regulatory modes; resilience; COVID-19; Covid-19 anxiety.

Online: 4 July 2023 (13:48:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0338.v1

Blood ACE2 protein level correlates with COVID-19 severity

Oksana Shevchuk, Anastasia Pak, Svitlana Palii, Yana Ivankiv, Kateryna Kozak, Mykhaylo Korda, Sandor G. Vari

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: COVID-19; ACE2; severity; post-COVID-19 patients; comorbidity.

Online: 5 June 2023 (14:36:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0361.v1

Revisiting Early-stage COVID-19 Strategy Options

Philip Machanick

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; pandemic; asymptomaticspread; early-stage COVID-19 mitigation

Online: 20 April 2020 (06:18:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0463.v1

Long-Term Antibody Response against SARS-CoV-2 in Health Care Workers: Effectiveness of Homologous and Heterologous Regimens and their Relation to Systemic Vaccine-Associated Symptoms

Helene Kierkegaard, Birgit Thorup Røge, Amanda Nissen, Jonna Skov Madsen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 vaccines; vaccine effectiveness; BNT162b2 vaccine; mRNA-1273 vaccine; ChAdOx1 vaccine; 19 Elecsys Anti-SARS-CoV-2 S assay; reactogenicity; vaccine-associated symptoms

Online: 26 August 2022 (14:14:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0413.v1

Knowledge, Attitudes and Practices regarding Long-Term Complications of COVID-19 among a Sub-Urban Population in Sri Lanka

Chamindri Witharana, Kithmini Siridewa, Manuj Weerasinghe, Indika Karunathilake

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: long COVID; COVID 19 vaccination; COVID awareness

Online: 24 December 2021 (23:40:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0783.v1

The Impact of COVID-19 on the Epidemiology and Outcomes of Candidemia: A Retrospective Study from a Tertiary Care Center in Lebanon

Aline El Zakhem, Omar Mahmoud, Johnny Zakhour, Sarah B. Nahhal, Nour El Ghawi, Nadine Omran, Walaa G. El Sheikh, Hani Tamim, Souha S. Kanj

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Candida; Candidemia; invasive candidiasis; Candida auris; non-albicans candida; COVID-19; antifungal susceptibility; Lebanon; Arab world; EQUAL score

Online: 11 May 2023 (04:37:02 CEST)

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Invasive fungal infections, notably candidemia, have been associated with COVID-19. The epidemiology of candidemia has significantly changed during the COVID-19 pandemic. We aim to identify the microbiological profile, resistance rates, and outcomes of COVID-19 associated candidemia (CAC) compared to patients with candidemia not associated with COVID-19. We retrospectively collected data on patients with candidemia admitted to the American University of Beirut Medical Center between 2004 and 2022. We compared the epidemiology of candidemia during and prior to the COVID-19 pandemic. Additionally, we compared the outcomes of critically ill patients with CAC to those with candidemia without COVID-19 from March 2020 till March 2022. Among 245 candidemia episodes, 156 occurred prior to the pandemic and 89 during the pandemic. Of the latter, 39 (43.8%) were CAC, most of which (82%) were reported from intensive care units (ICU). Non-albicans Candida (NAC) spp. were predominant throughout the study period (67.7%). Candida auris infection was the most common cause of NAC spp. in CAC. C. glabrata had decreased susceptibility rates to fluconazole and caspofungin during the pandemic period (46.1% and 38.4% respectively). Mortality rate in the overall ICU population during the pandemic was 76.6%, much higher than the previously reported mortality of candidemia from previous studies at our center. There was no significant difference in 30-day mortality between CAC and non-CAC (75.0% vs 78.1%; P =0.76). Performing ophthalmic examination (P = 0.002), CVC removal during the 48 hours following the candidemia (P = 0.008) and identifying the Candida spp. (P = 0.028) were significantly associated with a lower case-fatality rate. The epidemiology of candidemia has been significantly affected by the COVID-19 pandemic at our center. Rigorous infection control measures and proper antifungal stewardship are essential to combat highly resistant species like C. auris.

Preprint REVIEW | doi:10.20944/preprints202103.0490.v1

Long COVID, A Comprehensive Systematic Scoping Review

Hossein Akbarialiabad, Mohammad Hossein Taghrir, Ashkan Abdollahi, Nasrollah Ghahramani, Manasi Kumar, Shahram paydar, Babak Razani, John Mwangi, Ali A. Asadi-Pooya, Leila Malekmakan, Bahar Bastani

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Covid-19; Long Covid-19; Long Haulers Covid; Post Covid-19 Syndrome; Post-Acute Covid-19; Corona Virus; SARS-Cov-2; Novel Corona Virus 2019; Post-Acute SARS-CoV-2; PASC, Post-Acute Sequelae of COVID-19; Late Sequelae COVID-19

Online: 18 March 2021 (17:16:52 CET)

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Introduction: Despite more than one year passed since the first cases of SARS-CoV-2 were reported, there is still no consensus on the definition and clinical management of post-acute-COVID-19. The condition has heterogeneously been named as Chronic COVID syndrome, Post COVID-19 Syndrome, post-acute sequela of SARS-CoV-2 (PASC), and the more familiar long COVID. Method: In order to capture all relevant published studies, we undertook a multi-step search with no language restriction. The following four-step search strategy was utilized: First, a preliminary (limited) search was conducted on January 20, 2021, in Google Scholar and PubMed to identify the appropriate keywords. Then, on January 30, 2021, we adopted a search strategy of electronic databases from Cochrane Library, PsycINFO, PubMed, Embase, Scopus, and Web of sciences, using those keywords. Then, after duplicate removal, we screened all titles, abstracts, and full texts. This resulted in 66 eligible studies. Subsequently, after a forward and backward search of their references and citations an additional 54 publications were found, resulting in a total of 120 publications that formed the basis of the present analysis. The titles, abstracts, and full-texts of non-English articles were translated using Google Translate for further evaluation. We conducted our scoping review based on the PRISMA-ScR Checklist.Results: We found only one randomized clinical trial in our search. Of the 67 original studies, 22 were cohort and 28 were cross-sectional studies totaling 74.6% of the original studies. Of the total of 120 publications, 59 (49.1%) focused on signs and symptoms, 28 (23.3%) were focused on management, and 13 (10.8%) focused on pathophysiology. Ten (9%) publications focused on imaging studies. Ninety-one percent of the original investigations came from high and upper-middle-income countries, highlighting the scarcity of reports originating from low-income and lower-middle-income countries.Conclusion: The predominant symptoms among those with the so-called “Long COVID” were: fatigue, breathlessness, arthralgia, sleep difficulties, and chest pain. Recent reports also point to the risk of long-term sequela with cutaneous, respiratory, cardiovascular, musculoskeletal, mental health, neurologic, and renal involvement in those who survive the acute phase of the illness. The ambiguity and controversies in its definition have impaired proper recognition and management of those requiring additional support following the resolution of the acute phase of this infection. This has resulted in long-standing distress for the patients and their families. Our findings highlight the need for a multidisciplinary approach, support, and rehabilitation for these patients in terms of long-term mental and physical health.

Working Paper ARTICLE

COVID-19 Evolves in Human Hosts

Yanni Liu, Bing Liu, Jiangtao Cui, Zhi Wang, Yulong Shen, Yueshen Xu, Kaicheng Yao, Yuanfang Guan, Xiaoke Ma

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; divergence

Online: 21 July 2020 (13:46:45 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202006.0269.v1

A Case of HIV and Clinical Confirmed COVID-19

Cansu Ozgen, Ulku Arslan, Simay Serin, Hulya Sungurtekin

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: HIV; COVID-19

Online: 21 June 2020 (11:59:21 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202003.0077.v4

The Ongoing COVID-19 Epidemic Curves Indicate Initial Point Spread in China With Log-Normal Distribution of New Cases per Day With a Predictable Last Date of the Outbreak Version 4: Predictions for Selected European Countries, USA and the World as a Whole and Try to Predict the End of the Outbreak Including a Discussion of a Possible “New Normal”

Stefan Olsson, Jing Zhang

Subject: Biology And Life Sciences, Virology Keywords: epidemiology; COVID-19

Online: 19 April 2020 (08:15:10 CEST)

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During an epidemic outbreak it is useful for planners and responsible authorities to be able to plan ahead to estimate when an outbreak of an epidemic is likely to ease and when the last case can be predicted in their area of responsibility. Theoretically this could be done for a point source epidemic using epidemic curve forecasting. The extensive data now coming out of China makes it possible to test if this can be done using MS Excel a standard spreadsheet program available to most offices. The available data is divided up for whole China and the different provinces. This and the high number of cases makes the analysis possible. Data for new confirmed infections for Hubei, Hubei outside Wuhan, China excluding Hubei as well as Zhejiang and Fujian provinces all follow a log-normal distribution that can be used to make a rough estimate for the date of the last new confirmed cases in respective areas. In the version 2 continuation work, 9 additional days were added for the Chinese data to evaluate the previous predictions. The extra data then available from China follows the previous predicted trend supporting the usefulness of this simple technique. In the version 2 we also tested the feasibility for a non-specialist to make similar predictions using additional data from S Korea now available. In this third continuation the predictions for Version 2 are evaluated for S Korea and fits well the beginning of the decline but it seems to be difficult to bring down numbers of cases per day under about 100 new cases per day, potential reasons for this is discussed. To further evaluate when in a prediction becomes reliable the Chinese data was used to evaluate to make predictions for each day around the peak in number of cases and after2-3 consecutive days of decreasing new cases per day the prediction becomes reliable. In version 3 data for Italy just reaching this point was used to make further predictions for that country. A second new analysis was also added to use the fitted equation to detect when the acceleration of new cases per day stopped increasing exponentially. In the Chinese case this measured point coincides with the date of the complete Hubei lockdown and in the new Italian analysis it coincides with the mandatory Italian lockdown. Predicted dates for the end of the Italian outbreak is also added. In version 4 we expand the analysis to selected European countries, USA and the World as a whole and try to predict the end of the outbreak. We further discuss the apparent success of the used techniques that might work to introduce a “new normal” not very different to the previous to stop secondary outbreaks of COVID19 and future COVIDs that are sure to come.

Preprint ARTICLE | doi:10.20944/preprints202307.0248.v1

From Threatening Chaos to Temporary Order through a Complex Process of Adaptation: A Grounded Theory Study of the Escalation of Intensive Care during the COVID-19 Pandemic

Camilla Göras, Malin Lohela Karlsson, Markus Castegren, Emelie Coden Mellgren, Mirjam Ekstedt, Petronella Bjurling-Sjöberg

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Adaptive capacity; COVID-19; Grounded theory; Healthcare; Intensive care; Resilience; Resilient performance; Surge response; Unexpected crises

Online: 4 July 2023 (14:10:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1613.v1

Vaccination and Patient Status of Long COVID-19 Hospitalized Patients: A Cohort Observational Study

Simona Kirbiš, Nina Sobotkiewicz, Barbara Antolinc Schaubach, Jernej Završnik, Peter Kokol, Matej Završnik, Helena Blažun Vošner

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: long -COVID-19 syndrome; vaccination; comorbidities; COVID-19 pneumonia; observational

Online: 23 January 2024 (07:14:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.2032.v1

Radiological and Functional Pulmonary Evolution in Post-COVID-19 Patients: An Observational Study

Virgínia Maria Cavallari Strozze Catharin, Tereza Laís Menegucci Zutin, ELEN LANDGRAF GUIGUER, ADRIANO CRESSONI ARAÚJO, Lucas Fornari Laurindo, EDUARDO CHAGAS, Cássia Fernanda Gasparotti Zorzetto, PATRÍCIA BUENO, Manoela Dos Santos Bueno, Vitor Cavallari Strozze Catharin, HERON FERNANDO DE SOUZA GONZAGA, Sandra Maria Barbalho

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; post-COVID-19; pulmonary manifestations; spirometry; chest tomography.

Online: 28 July 2023 (12:48:47 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202303.0305.v1

COVID-19 Mitigation in a K-12 School Setting: A Case Study of Avenues: The World School in New York City

Ananya Iyengar, Steve Hanon, Richard Bruns, Paula Olsiewski, Gigi Gronvall

Subject: Social Sciences, Education Keywords: COVID-19 mitigation, education, indoor air quality, COVID-19 testing

Online: 16 March 2023 (11:16:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0414.v1

All-Cause Mortality According to COVID-19 Vaccination Status: an analysis of the UK Office for National Statistics Public Data

Alberto Donzelli, Giovanni Malatesta, Giovanni Di Palmo, Marco Cosentino, Marco Alessandria

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; COVID-19 vaccinations; all-cause mortality; relative risk

Online: 24 February 2023 (02:03:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0400.v1

Prevalence of Physical Symptoms and Burnout Syndrome in Healthcare Professionals after One Year of Pandemic: Study #COVID 19PS

Jordi Esquirol Caussa, Manuel García San Emeterio, Marta Méndez Olavide, Vanessa Bayo Tallón, Josep Sánchez Aldeguer

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID 19; health personnel; Burnout, Psychological; COVID 19 stress syndrome

Online: 26 September 2022 (11:42:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0415.v1

Knowledge Levels of Acceptance and Hesitancy of COVID-19 Vaccine Among General Population of the Kingdom of Saudi Arabia

Adi Essam Zarei, Bayan Sajer, Feda Alharshani, Afrah Alshehri, Lamar Faidah, Wafa Alshehri

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; Coronavirus; Vaccine hesitancy; COVID-19 Vaccine; Saudi Arabia

Online: 31 May 2022 (09:22:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0416.v1

Science’s Response to COVID-19

Yimon Aye, Marcus Long

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; CoVID-19 Dignosis; CoVID-19 Chemistry & Biology

Online: 16 March 2021 (11:54:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0275.v1

Analysis of the Primary Presenting Symptoms and Hematological Findings of COVID-19 Patients in Bangladesh

Abu Taiub Mohammed Mohiuddin Chowdhury, Md Rezaul Karim, H.M. Hamidullah Mehedi, Mohammad Shahbaz, Md Wazed Chowdhury, Guo Dan, Shuixiang He

Subject: Medicine And Pharmacology, Hematology Keywords: SARS-CoV-2; COVID-19; real-time RT-PCR; COVID-19 symptoms; COVID-19 hematological findings; Bangladesh

Online: 21 June 2020 (14:47:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0500.v1

A Deep Analysis on the Impact and Statistics of Covid-19 in Kerala, India – A Meta-Analysis Study

Merin Dickson, Anjana Abhilash, Gayathri G Menon, Sapna Chandran

Subject: Biology And Life Sciences, Virology Keywords: COVID-19; impact on society during COVID-19; behavioral impact of COVID-19; government policies against COVID-19; measures adopted by the government; COVID-19 Statistics; Infection rate and Data analysis

Online: 21 September 2020 (11:09:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0056.v1

Re-Orienting Nurturing Care for Early Childhood Development During the COVID-19 Pandemic in Kenya: A Review

Constance Shumba, Rachel Kimani, Sheila Shaibu, Gladys Mbuthia, Rose Maina, Stella Mbugua, Sweta Shah, Eunice Ndirangu, Amina Abubakar, Stanley Luchters

Subject: Social Sciences, Psychology Keywords: COVID-19; Impacts; Nurturing Care; Early Childhood Development (ECD); Maternal, Newborn, and Child Health; Child Growth Development; Early Brain Development; Vulnerable Children and Families

Online: 3 September 2020 (04:54:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1549.v1

Resident Impact of the Single Site Order Restricting Staff Mobility Across Long-Term Care Homes in British Columbia, Canada

Farinaz Havaei, Sabina Staempfli, Andy Ma, Joanie Sims-Gould, Thea Franke, Minjeong Park

Subject: Public Health And Healthcare, Health Policy And Services Keywords: patient supported research; COVID-19; older adult; mental health; pandemic management; policy evaluation; implementation science; staffing; quality of care; quality of life

Online: 25 October 2023 (04:12:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1611.v1

Comparative Analysis of COVID-19 Severity and Mortality Among Vaccinated and Unvaccinated Individuals During the Delta Variant Surge in a Tertiary Care Center

Fatemeh Hasani, Zahra Norouzi, Gholamreza Roshandel, Alireza Norouzi

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: coronavirus disease 2019 (COVID-19); delta variant; tertiary care; mortality; vaccination; severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2)

Online: 21 December 2023 (08:07:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1915.v1

The Effects of Diabetes and Being Overweight on Patients with Post-COVID-19 Syndrome

Simona Kirbiš, Nina Sobotkiewicz, Barbara Antolinc Schaubach, Jernej Završnik, Peter Kokol, Matej Završnik, Helena Blažun Vošner

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: post-COVID-19 syndrome; diabetes; overweight; COVID-19 pneumonia; observational study

Online: 29 August 2023 (03:18:29 CEST)

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In the aftermath of the COVID pandemic, post-COVID-19 syndrome (PCS) remains a challenge and may continue to represent a major health problem in the future. Moreover, the influence of type 2 diabetes and being overweight on PCS remains unclear. This study aimed to assess this influence. We performed an observational study from October 2020 to July 2022, which included 466 patients (269 males and 197 females) with a median age of 65. They were hospitalized due to COVID-19 pneumonia and had persistent symptoms after 1 month of COVID-19 infection. The patients were divided into four groups according to the study objectives: patients with type 2 diabetes, overweight patients, overweight patients with type 2 diabetes, and normal-weight patients without type 2 diabetes. The clinical and demographic data collected during hospitalization and regular visits at the Community Healthcare Center dr. Adolf Drolc Maribor were analyzed. Our results showed that type 2 diabetes patients had a more difficult course of treatment and longer hospitalization. Moreover, more type 2 diabetes patients underwent rehabilitation than the other study groups. The prevailing symptoms in our patients with PCS were dyspnea and fatigue, mostly in female patients with type 2 diabetes. Our study also showed that more women with type 2 diabetes and more overweight women with type 2 diabetes suffered from secondary infections. Further, more overweight patients were treated in the intensive care unit compared to the other groups. However, our study showed an interesting result that patients with type 2 diabetes had the shortest PCS durations. Type 2 diabetes and being overweight are risk factors for PCS onset and prolonged duration. Therefore, our data that revealed a shorter duration of PCS in type 2 diabetes patients compared to the other investigated groups was unexpected. We believe that answering this question regarding the results will enable us to improve PCS treatment in general.

Preprint ARTICLE | doi:10.20944/preprints202302.0136.v1

Fear of COVID-19, Risk Perception and Preventive Behavior in Health Workers: A Cross-Sectional Analysis in Middle-Income Latin American Countries

Cesar Antonio Bonilla-Asalde, Oriana Rivera-Lozada, Miguel Ipanaqué-Zapata, Elvis Siprian Castro-Alzate, Robinson Pacheco López, Isabel Cristina Rivera-lozada, FELIX CHONG, Lucrecia Ramirez Sagastume

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; SARS-CoV-2; health personnel; fear to COVID-19

Online: 8 February 2023 (02:34:46 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0336.v1

Combining Influenza and COVID-19 Booster Vaccination Strategy to Improve Vaccination Uptake Necessary for Managing the Health Pandemic: A Systematic Review and Meta-Analysis

Nikolaos Tzenios, Mary Tazanios, Mohamad Chahine

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19 Booster; Influenza and COVID-19; Vaccination Strategy; Combining Vaccination

Online: 17 November 2022 (10:31:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0024.v1

Predictors of Willingness of the General Public to Receive a Second COVID-19 Booster Dose or a New COVID-19 Vaccine: A Cross-Sectional Study in Greece

Petros Galanis, Irene Vraka, Aglaia Katsiroumpa, Olga Siskou, Olympia Konstantakopoulou, Theodoros Katsoulas, Theodoros Mariolis-Sapsakos, Daphne Kaitelidou

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: second COVID-19 booster; vaccination; COVID-19; willingness; predictors; general population

Online: 2 June 2022 (04:07:07 CEST)

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