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Preprint ARTICLE | doi:10.20944/preprints202206.0328.v1

Assessing the Spatiotemporal Relationship between Coastal Habitats and Fish Assemblages at Two Neotropical Estuaries of the Mexican Pacific

Victor Muro, Felipe Amezcua, Georgina Ramírez-Ortiz, Francisco Flores-de-Santiago, Felipe Amezcua-Linares, Yareli Hernandez

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: mangrove forests; Marine Protected Areas; α-diversity; β-diversity; multivariate analyses

Online: 24 June 2022 (03:28:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0257.v2

Quantifying Transcriptome Diversity: A Review

Emma Jones, Anisha Haldar, Vishal Oza, Brittany Lasseigne

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Gene expression; transcriptome diversity; transcriptional variation; transcript diversity; isoform-level diversity; gene-level diversity

Online: 13 April 2023 (03:07:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0118.v1

Long-Term Habitual Exercise and Combination of β-hydroxy-β-methylbutyrate Plus Black Ginger Maintain Muscle Health in SAMP8 Mice

Kai Aoki, Masaki Konno, Katsuyuki Tokinoya, Katsunari Honda, Takuya Abe, Takeshi Nagata, Masaaki Takehara, Takehito Sugasawa, Kazuhiro Takekoshi, Hajime Ohmori

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Sarcopenia; β-hydroxy-β-methyl butyrate Calcium; Black ginger

Online: 5 August 2020 (09:51:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0165.v1

Effects of β-Hydroxy-β-Methylbutyrate Supplementation on IL-4, IL-10 and TGF-β1 during Resistance Exercise in Athletes

Rahman Rahimi, Hamid Shoker Nejad

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: β-hydroxy-β-methylbutyrate, anti-inflamatory cytokines, resistance exercise

Online: 23 May 2017 (07:30:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0318.v1

Neuroprotective Activity of Mentha Species on Hydrogen Peroxide-Induced Apoptosis in SH-SY5Y Cells

Doaa M. Hanafy, Paul D. Prenzler, Geoffrey E. Burrows, Saliya Gurusinghe, Bashar Thejer, Hassan K. Obied, Rodney A. Hill

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; amyloid β; β-secretase; bax; caspase; lamiaceae; mint; oxidative stress

Online: 19 April 2020 (03:57:56 CEST)

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that develops as a consequence of different factors such as oxidative stress and accumulation of the protein amyloid β (Aβ) in the brain, resulting in apoptosis of neuronal cells. The search for a treatment for this disorder is essential as current medications are limited to alleviating symptoms and palliative effects. The aim of this study is to investigate the effects of mint extracts on selected mechanisms implicated in the development of AD. To enable a thorough investigation of mechanisms, including effects on -secretase (the enzyme the leads to the formation of A), on Aβ aggregation, and on oxidative stress and apoptosis pathways, a neuronal cell model, SH-SY5Y cells was selected. Six Mentha taxa were investigated for their in vitro β-secretase (BACE) and Aβ-aggregation inhibition activities. Also, their neuroprotective effects on H2O2-induced oxidative stress and apoptosis in SH-SY5Y cells were evaluated through caspase activity. Real-time PCR and Western blot analysis were carried out for the two most promising extracts to determine their effects on signalling pathways in SH-SY5Y cells. All mint extracts had strong BACE inhibition activity. M. requienii extracts showed excellent inhibition of Aβ-aggregation, while other extracts showed moderate inhibition. M. diemenica and M. requienii extracts lowered caspase activity. Exposure of SH-SY5Y cells to M. diemenica extracts resulted in a decrease in the expression of pro-apoptotic protein, Bax, and an elevation in the anti-apoptotic protein, Bcl-xL, potentially mediated by down-regulation of ASK1-JNK pathway. These results indicate that mint extracts could prevent the formation of Aβ and also could prevent their aggregation if they had already formed. M. diemenica and M. requienii extracts have potential to suppress apoptosis at the cellular level. Hence, mint extracts could provide a source of efficacious compounds for a therapeutic approach for AD.

Preprint ARTICLE | doi:10.20944/preprints202309.0973.v1

Effect of THC, CBD, THCV, CBC and CBN Cannabinoids on β-Cells Exposed to High Glucose—High Lipids

Esmaeel Ghasemi Gojani, Bo Wang, Dong-Ping Li, Olga Kovalchuk, Igor Kovalchuk

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: β-cell loss; β-cell dedifferentiation; diabetes; GSIS; THC; CBD; THCV; CBC; CBN

Online: 15 September 2023 (04:54:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0356.v1

A Robust Approach for Identification of Cancer Biomarkers and Candidate Drugs

Md. Shahjaman, Md. Rezanur Rahman, S. M. Shahinul Islam, Md. Nurul Haque Mollah

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cancer biomarker; DEGs; FC; β-divergence method; β-weight function; paired SAM; robustness

Online: 29 December 2018 (06:45:39 CET)

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Background: Identification of cancer biomarkers that are differentially expressed (DE) under two biological conditions is an important task in many microarray studies. There exist several methods in the literature in this regards and most of these methods designed especially for unpaired samples, which does not satisfy the requirements of paired samples where the gene expressions are taken from the same patients before and after treatment. Furthermore, the traditional biomarker identification methods based on either p-values or fold change (FC) values. However, sometimes, p-value based results do not comply with FC based results due to the smaller variance of gene expressions. There are some methods that combine both p-values and FC values to solve this problem. But, these methods also show weak performance for small-sample case in presence of outlying expressions. To overcome this problem, in this paper an attempt is made to develop a hybrid robust SAM-FC approach by combining rank of FC values and rank of p-values based on SAM statistic using minimum β-divergence method, which is designed for paired samples. This method introduces a weight function known as β-weight function. This weight function produces larger weights corresponding to usual/normal expressions and smaller weights for unusual/outlying expressions. The β-weight function plays the significant role on the performance of the proposed method. Results: The proposed method uses β-weight function as a measure of outlier detection by setting β=0.2. We unify both classical and robust estimates using β-weight function such that maximum likelihood estimators (MLEs) are used in absence of outliers and minimum β-divergence estimators are used in presence of outliers to obtain reasonable p-values and FC values in the proposed method. We examined the performance of proposed method in a comparison of some popular methods (t-test, SAM, LIMMA, Wilcoxon, WAD, RP and FCROS) using both simulated and real gene expression profiles for both small-and large-sample cases. From the simulation and a real spike in data analysis results we observed that the proposed method outperforms other methods for small-sample case in presence of outliers and it keeps almost equal performance with other robust methods (Wilcoxon, RP and FCROS) otherwise. From a head-and-neck cancer (HNC) dataset the proposed method identified 2 genes (CYP3A4, NOVA1) that are significantly enriched in linoleic acid metabolism, drug metabolism, steroid hormone biosynthesis and metabolic pathways. The survival analysis through Kaplan-Meier curve revealed that combined effect of these 2 genes has prognostic capability and they might be promising biomarker of HNC. Moreover, we retrieved the 12 candidate drugs based on gene interaction from glad4u and drug bank databases. Conclusion The identified drugs showed statistical significance and critical role of the proteins indicate that these proteins might be therapeutic target in cancer. Thus, elucidating the associations between the drugs identified in the present study require further investigations.

Preprint ARTICLE | doi:10.20944/preprints201808.0015.v1

A Novel Device-Free Counting Method Based on Channel Status Information

Junhuai Li, Pengjia Tu, Huaijun Wang, Kan Wang, Lei Yu

Subject: Computer Science And Mathematics, Computer Science Keywords: wavelet transform; covariance matrix; spatial diversity; frequency diversity; robustness

Online: 1 August 2018 (10:10:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints201707.0035.v1

The Importance of Controlling the TGF-β Signaling Pathway in the Gastric Cancer Microenvironment

Jun Kinoshita, Sachio Fushida, Tetsuo Ohta

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TGF-β; gastric cancer; microenvironment

Online: 14 July 2017 (11:59:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0826.v2

Associations Between β-Lactamase Types of Acinetobacter Baumannii and Antimicrobial Resistance

Kristina Černiauskienė, Asta Dambrauskienė, Astra Vitkauskienė

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Acinetobacter baumannii; extended spectrum β-lactamase; AmpC β-lactamase; Klebsiella pneumoniae carbapenemase; multidrug resistance

Online: 12 June 2023 (14:26:40 CEST)

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Background and objective: Acinetobacter baumannii (A. baumannii) is an important nosocomial pathogen that possesses not only intrinsic resistance to many classes of antibiotics, but also is capable to rapidly develop antimicrobial resistance during treatment. The aim of our study was to determine the production of different types of β-lactamases (AmpC, ESBL, KPC) in A. baumannii strains, to evaluate its association with antimicrobial resistance, and to identify the changes in these characteristics after 5 years. Materials and methods: A total of 233 A. baumannii strains were isolated from different clinical specimens of patients treated at the Hospital of Lithuanian University of Health Sciences in 2016–2017 and 2021–2022. All clinical cultures positive for A. baumannii were analyzed. The type of β-lactamase was detected by phenotypic methods using ESBL plus AmpC screen disk tests and the combination meropenem disk test. Results: In 2016–2017 and 2021–2022, all A. baumannii strains were resistant to ciprofloxacin; more than 80% were resistant to carbapenems, piperacillin/tazobactam, gentamicin, and tobramycin. Comparison of two different period showed that the production of two different types of β-lactamases increased more than 5-fold (from 17.7% to 94.2%, p < 0.001), and the production of all three types of β-lactamases, more than 4-fold (from 1.3% to 5.8%, p < 0.001). A. baumannii strains producing two or three types of β-lactamases were more often resistant to tigecycline, tetracycline, and doxycycline than strains producing one type of β-lactamases (p < 0.001). Conclusions: The frequency of isolation of A. baumannii strains producing two or three β-lactamases types and the resistance rates to ampicillin/sulbactam, tigecycline, tetracycline, and doxycycline increased in 2020–2021 as compared with 2016–2017. The production of two or three types of β-lactamases by A. baumannii strains was associated with higher resistance rates to tetracyclines.

Preprint ARTICLE | doi:10.20944/preprints202401.0404.v1

Effects of Land Cover on Taxonomic and Functional Diversity of the Bird Communities in a Subtropical Mountain

Wenwen Zhang, Shengjun Zhao, Xiao Yang, Jing Tian, Ding Chen, Yuan Yu, Jie Shi, Peng Cui, Xue Wang, Chunlin Li

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Bird community; Functional diversity; Taxonomic diversity; Landscape pattern; Mountain city

Online: 4 January 2024 (11:28:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1956.v1

Building a Teleost Fish Traceability Program Based on Genetic Data from Pacific Panama Fish Markets

Edgardo Enrique Díaz-Ferguson, Magaly Sánchez De Chial, Maribel Arlene González Torres, Edgardo A. Muñoz T., Magister Olga Chen, Ovidio Durán, Angel Javier Vega, Carlos Ramos Delgado

Subject: Biology And Life Sciences, Aquatic Science Keywords: COI; teleostei; nucleotide diversity; haplotypic diversity; qPCR; demographic history; environmental DNA

Online: 28 June 2023 (07:37:41 CEST)

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Fish tissue samples from 203 adult individuals were collected in the main ports and markets of the Pacific coast of Panama. Molecular identification based on cytochrome oxidase I gene segment of all species was verified GENBANK reference sequences. 34 species from 14 families (Ariidae, Lutjanidae, Caranjidae, Scianidae, Centropomidae, Serranidae, Scombridae, Sphyraenidae, Haemulidae, Gerreidae, Stromotidae, Lobotidae, Malacanthidae, Mugilidae) were identified at species molecular level from 164 sequences. Also, three Caribbean species were molecularly identified among the analyzed samples (Mycteroperca xenarcha, Paralonchurus brasilensis and Lobotes surinamensis). Species diversity was slightly higher in the Gulf of Panama than in the Gulf of Chiriquí. For species with 5 or more individual sequences, genetic diversity and genetic connectivity parameters such as: total number of haplotypes (H), haplotype diversity (Hd), and nucleotide diversity (π) were calculated. Overall, pelagic-migratory species showed higher values of genetic diversity than coastal and estuarine species with some exceptions. Connectivity between Gulf areas was compared using values of genetic distances and genetic differentiation (Fst). High level of connectivity observed between Gulf of Chiriqui and Gulf of Montijo indicates the existence of a single stock in that area for the following species: Scomberomorus sierra, Caranx caninus and Lutjanus guttatus. Demographic history of the most common species was examined using Tajima’s D values suggesting population expansion for two snapper species, L. peru and L. argentiventris, having significant and higher values. Another important contribution from this research was the production of primers and dual labeled probes for environmental DNA detection using qPCR for the five most abundant species (spotted rose snapper, yellow snapper, green jack, Pacific crevalle jack and the Pacific sierra fish). These markers represent a new set of tools for environmental DNA (eDNA) detection and molecular traceability of three commercially important fish species along the supply chain including landing sites and markets of the main fishery areas.

Preprint ARTICLE | doi:10.20944/preprints202001.0038.v1

Responses of Individual Plant Species, Functional Groups, α- and β-Diversity to Short-Term Grazing Exclusion under Severe Drought Episode in Long-Term Grazed Alfa-Steppes

Yacine Kouba, Saifi Merdes, Badreddine Saadali, Haroun Chenchouni

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Mediterranean steppes; drylands; alpha diversity; beta diversity; rangeland grazing; indicator species

Online: 5 January 2020 (15:22:33 CET)

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Grazing exclusion has been proved to be one of the main measures for rehabilitating degraded arid steppes. However, the effect of this management practice on plant species diversity and composition is ambiguous, specially under prolonged droughts. Concurrently considering the responses of individual plant species, diversity of functional groups, α-diversity, and β-diversity (and its components) may be crucial to the holistic understanding of grazing exclusion effects on plant communities under drought conditions. Here, we investigated the response of these diversity measures to short-term sheep exclusion under severe drought episode in arid steppes of Alfa-grass (Stipa tenacissima) with a long evolutionary history of livestock grazing. Individual species responses were tested based on species occurrence and abundance in either grazed or grazing-excluded steppes, in addition, we used indicator species analysis to assess the strength of the association between plant species and management type. Likewise, α-diversity, abundance- and incidence-based β-diversity, as well as the functional groups’ diversities were quantified using Hill Numbers and compared between the two management types. Sheep grazing exclusion enabled the recovery of various Alfa-steppe indicator species and improved the size of regional species pool, overall α-diversity, and the diversity of therophytes. This management practice decreased the abundance-based β-diversity and the nestedness-resultant fraction of the incidence-based β-diversity at the local scale, while at the landscape scale increased the abundance-based β-diversity and its balanced variation fraction and reduced the incidence-based β-diversity and its turnover component. Furthermore, protection from grazing altered β-diversities scaling patterns by maintaining higher balanced variation in species abundance at large spatial scale and greater abundance-gradient in species composition at the fine-scale. Our results suggest that the implementation of short-term grazing exclusion in degraded arid steppes would be the appropriate management practice for vegetation restoration and plant diversity conservation during prolonged drought periods.

Preprint ARTICLE | doi:10.20944/preprints202311.1188.v1

A New Method for Immobilization of β‐Galactosidase on Glass Fibre Rolls

Darja Pečar, Katja Zečević, Andreja Goršek

Subject: Chemistry And Materials Science, Food Chemistry Keywords: β-galactosidase; immobilization; glass fibers; lactose

Online: 21 November 2023 (10:41:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.0235.v1

Recent Advances in β-glucosidase Engineering: A Brief Review

Xihua Zhao, Yunhong Huang, Bei Ouyang, Guoping Wang, Nian Zhang, Jiali Zuo

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: β-glucosidase; biocatalysis; biosynthesis; enzyme engineering

Online: 5 June 2023 (04:30:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0078.v1

At the Intersection of Cardiology and Oncology: TGFβ as a Clinically Translatable Therapy for TNBC Treatment and as a Major Regulator of Post-Chemotherapy Cardiomyopathy

Andrew Sulaiman, Jason Chambers, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri, Sarah McGarry, Sung Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cardiology; Oncology; CSC; TNBC; TGF-β

Online: 7 February 2022 (11:19:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0192.v1

Multidrug Resistance Behaviors of Clinical Pseudomonas aeruginosa Strains Associated to Pigment Coloration

Ashish Kothari, Rohitash Yadav, Prashant Rajput, Vanya Singh, Karanvir Kaushal, Neeraj Jain, Balram Ji Omar

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pigment; β-lactamase; MIC; Biofilm; Efflux

Online: 7 June 2021 (15:32:43 CEST)

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Pseudomonas aeruginosa is an adaptable bacterial pathogen that infects various organs, including the respiratory tract, vascular system, urinary tract, and central nervous system leading to high morbidity and mortality. Our primary focus of this study was to characterize P. aeruginosa clinical strains on the basis of pigment color production, determine its association to multidrug resistance behavior and ability to form biofilm. We identified yellow (30.1%), green (39.8%) and no pigment (30.1%) producing strains from a total of 143 clinical isolates. Yellow pigment producing strains presented significant resistance to a class of antibiotics including β-lactam (91.5%), aminoglycosides (70.5%), and carbapenems (51.9%) compared to green and non-pigmented strains. Importantly, 16.3% of yellow pigment producing strains was resistant to colistin where only 2.3% of non-pigmented and 1.8% of green pigmented strains were resistant to this agent. Moreover, yellow pigment producing strain were frequent producers of β-lactamase group of enzymes, ESBL (55.6%), MBL (55.6%), and AmpC (50%) and displayed higher frequency of efflux positive group (64.2%) compared to green (7.14%) and non-pigmented one (28.5%). Notably, green pigment producing strains when compared to non-pigmented groups also displayed antibiotic susceptibility behavior similar to yellow pigment producing strains. Although yellow pigment producing strains were strong biofilm producers, no significant association was identified between pigment and biofilm formation. Among pigmented and non-pigmented strains, majority of yellow pigment producing strains have shown MIC levels greater than the green and non-pigmented strains. Our study has demonstrated the impact of pigment coloration on susceptibility to antimicrobial agents where yellow pigment producing strains represent considerably a serious problem as due to lack of alternative agents against such transformed strain may collectively be associated with multidrug resistance development.

Preprint ARTICLE | doi:10.20944/preprints202103.0426.v1

Live Cell FRET Imaging Reveals Amyloid β-Peptide Oligomerization in Hippocampal Neurons

Yang Gao, Stefan Wennmalm, Bengt Winblad, Sophia Schedin-Weiss, Lars Tjernberg

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: amyloid β-peptide; oligomerization; aggregation; FRET

Online: 16 March 2021 (13:29:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0250.v1

Intestinal Absorption of β-Glucans and Their Effect on the Immune System

Shingo Hino, Naomichi Nishimura, Tsukasa Matsuda, Tatsuya Morita

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: β-glucan; intestinal absorption; immune system

Online: 10 December 2020 (11:30:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0025.v1

Effects of β-Mannanase and Bacteriophage Supplementation on Health and Growth Performance of Holstein Calves

Sinyong Jeong, Junsung Lee, Namchul Jo, Jung-Jin Lee, Jae-Hwan Lee, Dong-Keun Kam, Jakyeom Seo, Ermias Kebreab, Seongwon Seo

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: β-mannanase; bacteriophage; calf, growth; survival

Online: 1 October 2020 (16:46:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0589.v1

Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-lactamases

Vivek Keshri, Eric Chabrière, Lucile Pinault, Philippe Colson, Seydina Diene, Jean-Marc Rolain, Didier Raoult, Pierre Pontarotti

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: β-lactamase; convergent evolution; antibiotic resistance

Online: 24 July 2020 (13:59:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0244.v1

Selective Modification of Streptozotocin at the C3 Position to Improve Its Bioactivity as Antibiotic and Reduce Its Cytotoxicity towards Insulin-Producing β Cells

Ji Zhang, Liubov Yakovlieva, Bart J. de Haan, Paul de Vos, Adriaan J. Minnaard, Martin D. Witte, Marthe T.C. Walvoort

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: antibiotics; β cells; streptozotocin; regioselective oxidation

Online: 15 March 2020 (13:12:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201809.0496.v1

On the Use of Electrosprayed Agave Fructans as Nanoencapsulating Hydrocolloids for Bioactives

Jorge A. Ramos-Hernández, Juan A. Ragazzo-Sánchez, Montserrat Calderón-Santoyo, Rosa I. Ortiz-Basurto, Cristina Prieto, Jose M. Lagaron

Subject: Chemistry And Materials Science, Nanotechnology Keywords: HDPAF; β-carotene; electrospraying; encapsulation; photoprotection

Online: 26 September 2018 (04:38:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0005.v1

Obtaining of β-Sitosterol from Cardamom by Supercritical CO₂ Extraction

Hacer İçen, Hatice Tuğba Çelik, Mustafa Serhat Ekinci, Metin Gürü

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardamom; supercritical CO2 extraction; β-sitosterol

Online: 1 November 2017 (04:54:35 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201612.0122.v1

The Food and Beverage Occurrence of Furfuryl Alcohol and β-myrcene – Two Emerging Potential Human Carcinogens?

Alex O. Okaru, Dirk W. Lachenmeier

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: furfuryl alcohol; β- myrcene; carcinogens; occurrence

Online: 25 December 2016 (08:21:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0268.v1

Catch Composition, Seasonality and Biological Aspects of Sharks Caught in the Ecuadorian Pacific

Jesús Briones-Mendoza, Diego Mejía, Pol Carrasco-Puig

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: diversity; abundance; cartilaginous fish

Online: 20 June 2022 (10:10:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0050.v1

Diversity and Reassortment Rate of Influenza a Viruses in Wild Ducks and Gulls

Yulia Postnikova, Anastasia Treshchalina, Elizaveta Boravleva, Alexandra Gambaryan, Aydar Ishmukhametov, Mikhail Matrosovich, Ron A.M. Fouchier, Galina Sadykova, Alexei Prilipov, Natalia Lomakina

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Avian influenza; Reassortment; Diversity

Online: 5 May 2021 (12:32:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0010.v1

Biological Hotspot of Ichthyoplankton in the Estuarine Environment Timbulsoko Village, Demak

Hanityo Adi Nugroho, Sutrisno Anggoro, Ita Widowati

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: Diversity; Ecology; Fishes; Geoscience

Online: 2 December 2019 (10:38:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0346.v1

Biological Hotspot larva Ikan Diperairan Estuari Desa Timbulsoko, Demak

Hanityo Nugroho, Sutrisno Anggoro , Ita Widowati

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: diversity; ecology; fishes; geoscience

Online: 31 July 2019 (04:40:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0308.v1

Effects of Different Feeding Patterns on the Rumen Bacterial Community of Tan Lambs, based on High-Throughput Sequencing of 16S rDNA Amplicons

Lili Zhang, Yanliang Bi, Jie Zhang, Zilin Fu, Xiaofeng Xu

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Alpha diversity; Beta diversity; Mutton quality; Pasture-fed; Pen-fed; Tan lambs

Online: 13 April 2023 (08:01:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0018.v2

Comparing Measures of Community Lineage Diversity across North American Forests

Kyle G. Dexter, Ricardo A. Segovia, Andy Griffiths

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: temperate forests; species richness; lineage diversity; phylogenetic diversity; United States; trees; TILD

Online: 13 February 2019 (10:15:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0283.v1

Geomorphology and Altitude Effects on Diversity and Structure of Vanishing Montane Forest of Southern Ecuador

Omar Cabrera, Angel Benítez, Nixon Cumbicus, Carlos Naranjo, Pablo Ramón, Fani Tinitana, Adrián Escudero

Subject: Biology And Life Sciences, Forestry Keywords: alpha diversity; beta diversity; floristic arrangement; geological landscapes; geomorphology; Ecuador; mountain forests

Online: 15 October 2018 (06:19:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0060.v1

Doubling the Accuracy of Indoor Location: Frequency Diversity

Berthold Horn

Subject: Engineering, Electrical And Electronic Engineering Keywords: indoor location; fine time measurement; round trip time; FTM; RTT; IEEE 802.11mc; IEEE 802.11-2016; time diversity; spatial diversity; bandwidth diversity; frequency diversity; Bayesian grid; observation model; transition model

Online: 8 January 2020 (04:18:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0507.v1

Cereal β-D-glucans: From Biosynthesis and Breeding Possibilities to Food Processing Applications

Michaela Havrlentová, Václav Dvořáček, Lucie Jurkaninová, Veronika Gregusová

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: β-D-glucans; cereals; biosynthesis; food application

Online: 8 May 2023 (10:11:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0354.v1

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)

Shurong Hou, Juan Diez, Chao Wang, Christoph Becker-Pauly, Gregg B. Fields, Thomas Bannister, Timothy P. Spicer, Louis D. Scampavia, Dmitriy Minond

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: meprin α; meprin β; zinc metalloproteinase; uHTS

Online: 14 December 2020 (16:36:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0597.v1

Are Hydrogen Peroxide, Hypochlorite and Peracetic Acid Potential Endocrine Disruptors?

Shu-shu Zhong, Jun Zhang, Ze-hua Liu, Zhi Dang, Yu Liu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Arylsulfatase; β-glucuronidase; Hydrogen peroxide; Hypochlorite; Inhibition

Online: 23 November 2020 (19:22:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0207.v1

Serum Amyloid A Was Correlated with Osteonecrosis of the Femoral Head by Affecting Bone Metabolism

Xiaoyuan Peng, Qiyang Wang, Yanchun Gao, Guangyi Li, Yong Feng, Changqing Zhang

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: SAA; ONFH; proteomics; Wnt/β-catenin; PPARγ

Online: 10 October 2018 (07:42:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0103.v1

Microsatellite Sequence Polymorphisms Reveals Substantial Diversity in Caribbean Breadfruit [Artocarpus altilis (Parkinson) Fosberg] Germplasm

Oral O Daley, Angela T Alleyne, Laura B Roberts-Nkrumah, Lambert A Motilal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Crop germplasm; genetic diversity; nucleotide diversity; nucleotide polymorphism; SSR markers; un-derutilized crop

Online: 2 February 2024 (04:54:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1730.v1

Genetic Diversity of Human Norovirus in Children Less Than 5 Years of Age With Acute Gastroenteritis in Rural Communities in the Gambia

Sheriffo Jagne, M. Jahangir Hossain, Martin Antoni, Abdul Karim Sesay, Muhammed Khalie Abdul, Nuredin I. Mohammed, Madikay Senghore, Alansana Darboe, Jarra Manneh, Abdoulie Kanteh, Dam Khan, Saikou Y Bah, Ndaw Sylvanus Peter, Osbourne Quaye, George Enyimah Armah

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Norovirus genetic diversity genogroups genotypes

Online: 24 January 2024 (10:15:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1390.v1

Evaluation of Wild Raspberry (Rubus idaeus L.) Ecotypes from Northeastern Türkiye

Gulce Ilhan

Subject: Biology And Life Sciences, Horticulture Keywords: Raspberry; underutilized fruits; characterization; diversity

Online: 19 January 2024 (03:12:32 CET)

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Located between Asia and Europe, Türkiye is very rich in terms of wild edible fruit diversity. One of the most important wild edible fruits in Türkiye is red raspberries and they widely found in cold to warm temperate regions in the country. The wild raspberries in general have red fruit color but yellow fruited genotypes are evident. A total of 11 wild grown red raspberry genotypes sampled in Northern Anatolia region was used in this study and their sensory, biochemical and antioxidant characteristics were determined. For sensory analysis aroma, taste and juiciness were used as the main criteria to compare ecotypes each other. Biochemical and antioxidant characteristics of ecotypes included SSC (Soluble Solid Content), vitamin C, organic acids, total anthocyanins (TA), total phenolic content, total flavonoid content and total antioxidant capacity. FRAP (Ferric Reducing Antioxidant Power) assay was used to determine antioxidant capacity. There were significant differences among ecotypes for most of the searched parameters even they found similar growing condition. The ecotypes had fruit weight between 1.04 g and 1.33 g, and fruit Chroma value between 26.11 and 33.70. Vitamin C content of ecotypes were quite variable and ranged from 29.3 mg/100 g to 41.4 mg/100 g. The total phenolic content, total anthocyanin content, total flavonoid content was between 164-362 mg gallic acid equivalent/100 g; 17.3-33.3 mg cyanidin-3-glucoside equivalent/100 g and 10.3-17.2 mg quercetin equivalent/100 g, respectively. Citric acid was the dominant organic acid for all genotypes and ranged from 10.3-14.6 g/100 g fresh weight base. According to the results V-4, V-8, V-3 and V-10 had attractive bigger fruits indicate their suitability for fresh consumption. V-3 and V-5 had sweeter fruits indicated their suitability for processing and V-6, V-7 and V-11 had richer for human health promoting compounds (higher total phenolic content and antioxidant capacity), making them suitable for future use as functional foods and as promising sources of natural antioxidants.

Preprint REVIEW | doi:10.20944/preprints202206.0284.v1

Building Consensus around the Assessment and Interpretation of Symbiodiniaceae Diversity

Sarah Davies, Matthew H. Gamache, Lauren I. Howe-Kerr, Nicola G. Kriefall, Andrew C. Baker, Anastazia T. Banaszak, Line K. Bay, Anthony J. Bellantuono, Debashish Bhattacharya, Cheong Xin Chan, Danielle C. Claar, Mary Alice Coffroth, Ross Cunning, Simon K. Davy, Javier del Campo, Erika M. Diaz-Almeyda, Jorg C. Frommlet, Lauren E. Fuess, Raul A. Gonzalez-Pech, Tamar L. Goulet, Kenneth D. Hoadley, Emily J. Howells, Benjamin C. C. Hume, Dustin W. Kemp, Carly, D. Kenkel, Sheila A. Kitchen, Todd C. LaJeunesse, Senjie Lin, Shelby McIlroy, Ryan McMinds, Matthew R. Nitschke, Clinton A. Oakley, Raquel S. Peixoto, Carlos Prada, Hollie M. Putnam, Kate Quigley, Hannah G. Reich, James Davis Reimer, Mauricio Rodriguez-Lanetty, Stephanie Rosalas, Osama S. Saad, Eugenia M. Sampayo, Scott Santos, Eiichi Shoguchi, Edward G. Smith, Michael Stat, Timothy G. Stephens, Marie E. Strader, David J. Suggett, Timothy D. Swain, Cawa Tran, Nikki Traylor-Knowles, Christian R. Voolstra, Mark E. Warner, Virginia M. Weis, Rachel Wright, Tingting Xiang, Hiroshi Yamashita, Maren Ziegler, Adrienne M.S. Correa, John Everett Parkinson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Symbiodinaceae; genetic diversity; coral symbiosis

Online: 21 June 2022 (04:49:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0397.v1

Simple Method for Assessing Diversity and Dynamics of Microbial Community: Comparison of Dairy Phages from Industrial and Spontaneous Fermentation

Agnieszka Olejnik-Schmidt, Bernadeta Pietrzak, Iwona Kawacka, Klaudia Malak, Weronika Wawrzyniak, Marcin Schmidt

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: phage; dairy; Lactococcus; diversity; community

Online: 19 August 2021 (10:30:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0254.v1

Distribution of Insect in Protected Forest Area in Ambon City

fransina latumahina

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Insects; Diversity; ecosystem health; Ambon

Online: 9 March 2021 (10:03:23 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202008.0021.v1

Safe Fieldwork Strategies for At-Risk Individuals

Amelia-Juliette Demery, Monique Pipkin

Subject: Social Sciences, Safety Research Keywords: diversity; inclusion; equity; fieldwork; research

Online: 2 August 2020 (11:55:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0366.v1

Does Islam Practice Tolerance? Some Notes from Quranic Perspective

Abur Hamdi Usman

Subject: Social Sciences, Religion Keywords: Tolerance; Religion; Islam; Society; Diversity

Online: 19 July 2018 (15:43:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0179.v1

Economic Diversity and the Resource Curse: A Dynamic Panel Model

Fred Olayele, Kwok Soo

Subject: Business, Economics And Management, Economics Keywords: Diversity; resource curse; economic growth.

Online: 13 April 2018 (14:18:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0247.v1

Species Diversity of Oak Stands and Its Significance for Drought Resistance

Jan Kotlarz, Sylwia Nasiłowska, Karol Rotchimmel, Katarzyna Kubiak

Subject: Environmental And Earth Sciences, Environmental Science Keywords: drought; diversity; oaks; remote sensing

Online: 26 January 2018 (04:52:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0116.v1

Evaluation of Diversification Techniques for Legal Information Retrieval

Marios Koniaris, Ioannis Anagnostopoulos, Yannis Vassiliou

Subject: Computer Science And Mathematics, Information Systems Keywords: diversity; algorithms; legal information retrieval

Online: 23 November 2016 (09:50:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0385.v1

mySORT: A Web Framework by using Deconvolution Approach to Estimating Immune Cell Composition from Complex Tissues

Shu-Hwa Chen, Bo-Yi Yu, Wen-Yu Kuo, Ya-Bo Lin, Sheng-Yao Su, I-Hsuan Lu, Chung-Yen Lin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cancer; Immunotherapy; Deconvolution; Alpha diversity; Beta diversity; Precision medicine; Microenvironment; Single-cell RNA sequencing

Online: 13 November 2020 (14:18:40 CET)

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Cancer immunotherapy reaches a remarkable achievement in various cancer types and brings new possibilities to improve cancer patients’ long-term survival. However, outcomes vary from case to case, and the present protocol benefits a small fraction of patients. One notable factor is the tumor microenvironment, especially the immune cell components, that may reflect the immune response's status quo on site. Thus, understanding the content of infiltrating immune cells in tumors is not only for research interesting but also a crucial subject toward precision medicine. We implement an algorithm for resolving relative proportions of twenty-one immune cell subclasses from a human tissue profiled transcriptome by microarray technology to reach the goal above. By selecting gene features and then adopting ?-Support Vector Regression, we can construct a deconvolution model and resolve the immune cell context. The excellent consistency between the estimated values and the correct immune-cell composition further demonstrates this approach provides a more natural alternative to revealing samples' immune cell content and reliable results like recent single-cell technologies. Based on this algorithm, the web-based deconvolution tool implemented named mySORT provides a user-friendly interface for estimating the immune cell content by uploading gene expression profiling. We also present comprehensive visualization 2D/3D plots in mySORT so that users can easily make a comparison between different samples. Finally, we synthesized pseudo-bulk expression data from single-cell transcriptomic datasets of 17 melanoma and 16 head and neck cancer patients. The deconvolution results of microarray-based data in the previous study and synthetic pseudo-bulk data all proved the excellent performance of mySORT. We believe that mySORT can help researchers in all fields easily understand complex immune microenvironment. The website of mySORT is freely accessible on https://symbiosis.iis.sinica.edu.tw/mySORT/.

Preprint ARTICLE | doi:10.20944/preprints201811.0627.v1

BIOFACQUIM: A Mexican Compound Database of Natural Products

B. Angélica Pilón-Jiménez, Fernanda I. Saldívar-González, Bárbara I. Díaz-Eufracio, José L. Medina-Franco

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: chemical space; chemical data set; chemoinformatics; consensus diversity plot; drug discovery; molecular diversity; visualization

Online: 30 November 2018 (10:06:15 CET)

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Working Paper REVIEW

Bioactive Substances in Trees and Shrubs of Central Europe

Lidia Szwajkowska-Michalek, Anna Przybylska-Balcerek, Tomasz Rogoziński, Kinga Stuper-Szablewska

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: bioactive compounds from European trees and shrubs; gallic and cinnamic acids; quercetin; pinosylvin; β–sitosterol; alfa- and β-pinene

Online: 28 October 2019 (11:57:17 CET)

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Working Paper ARTICLE

Red Light Control of β-Carotene Isomerisation to 9-cis β-Carotene and Carotenoid Accumulation in Dunaliella salina

Yanan Xu, Patricia J Harvey

Subject: Biology And Life Sciences, Plant Sciences Keywords: 9-cis β-carotene; all-trans β-carotene; Dunaliella salina; red LED; blue LED; growth; light intensity; carotenoids; isomerisation

Online: 17 May 2019 (08:25:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0207.v1

Fungal Biotransformation of a β-Lactam Antibiotic Ampicillin under Laccase-Induced Conditions

Bouthaina Ghariani, Abdulrahman H. Alessa, Imen Ben Atitallah, Ibtihel Louati, Ahmad A Alsaigh, Tahar Mechichi, Héla Zouari-Mechichi

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Antibiotics; Ampicillin; β-lactam; Coriolopsis gallica; Biotransformation; Laccase.

Online: 5 March 2024 (09:13:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0146.v1

β-Lactam TRPM8 Antagonists Derived from Phe-Penylalaninol Conjugates: Structure-Activity Relationships and Antiallodynic Activity

Cristina Martín-Escura, M. Ángeles Bonache, Jessy A. Medina, Alicia Medina-Peris, Jorge De Andrés-López, Sara González-Rodríguez, Sara Kerselaers, Gregorio Fernández-Ballester, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: TRPM8 channel; β–lactams; antagonists; docking; antinociceptive activity

Online: 4 September 2023 (08:34:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0140.v1

Effects of Duration of Calcium Propionate Supplementation in Lambs Finished with Supplemental Zilpaterol Hydrochloride: Productive Performance, Carcass Characteristics, and Meat Quality

Octavio Carrillo-Muro, Alejandro Rivera-Villegas, Pedro Hernandez-Briano, Marco Antonio Lopez-Carlos, Alejandro Plascencia Jorquera

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: crossbred lambs; gluconeogenic precursor's; duration; β-adrenergic agonists.

Online: 4 September 2023 (08:31:28 CEST)

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Forty-five male Dorper crossbred lambs (40.17 ± 0.35 kg BW) were used in order to investigate the effects of the duration of calcium propionate (CaPr) supplementation in lambs finished with zilpaterol hydrochloride (ZH) on the productive performance, carcass characteristics, and meat quality. Lambs were individually housed and fed a finishing-diet for 42 d before being slaughtered. Lambs received the following treatments: 1) No additives (CTL), 2) ZH supplementation for 28 d (with 3 d ZH withdrawal before slaughter) at a dosage of at 7.2 mg/kg diet (ZH), for treatments 3, 4, and 5, lambs received ZH and 10g CaPr/lamb/d throughout the entire phase (42 d), or during the last 28 or 14 d before slaughter. Compared to CTL, ZH lambs exhibited a similar average daily gain (ADG) but had lower dry matter intake (DMI), leading to increased feed efficiency. Supplementing with ZH alone did not affect carcass traits, visceral mass, whole cuts, or meat quality. Lambs that received both CaPr and ZH exhibited quadratic increases (p < 0.05) in final BW (FBW), ADG, and dressing percentage (D%). These increases were optimal at an estimated inclusion durations of 26 d for FBW, 30 for ADG, and 39 d for D%. The ADG:DMI ratio and the longissimus muscle area (LMA) both exhibited quadratic increases (p < 0.05). The optimal duration of CaPr supplementation for ADG:DMI ratio was found to be 28 d, while for LMA, it was 14 d. As the period of CaPr supplementation increased, there was a linear increase (p <0.05) in hot carcass weight, leg circumference, and whole cuts of breast IMPS209 and shoulder IMPS207. Cook loss percent increased quadratically (p < 0.05), being higher when CaPr was included for an estimated duration of 26 d. As the duration of CaPr supplementation increased, the purge loss percentage (PLR) also increased linearly (p < 0.05). In conclusion, including CaPr in the diet for a duration of 28 d in lambs improved the response to ZH supplementation on the productive performance, carcass weight and some whole cuts. However, it can also have a negative effect on PRL%.

Preprint ARTICLE | doi:10.20944/preprints202308.1710.v1

Analysis of 14 β-Agonists in Pork Using Automated Wooden Tip Based SPME Device and UPLC-MS/MS

Kai Li, Xiaoming Gong, Liming Jin, Mengxiao Liu, Mengmeng Hua

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: β-agonists; LC-MS/MS; automated SPME; pork

Online: 24 August 2023 (04:45:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2120.v1

Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo

Ji Heun Jeong, Geum-Lan Hong, Young Gil Jeong, Nam Seob Lee, Do Kyung Kim, Jong Yea Park, Mina Park, Hyun Min Kim, Ya El Kim, Yung Choon Yoo, Seung Yun Han

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease, Medicinal mushroom, Amyloid β, Zinc, 5XFAD

Online: 31 July 2023 (11:31:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1993.v1

Efficiency Assessment between Entrapment and Covalent Bond Immobilization of Mutant β-Xylosidase onto Chitosan Support

Gabriela Romero B., Lellys M. Contreras, Aguirre Carolina, Wilkesman Jeff, Josefa María Clemente-Jiménez, Felipe Rodríguez-Vico, Francisco Javier Las Heras-Vázquez

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: β-xylosidase; chitosan; enzyme immobilization; G. stearothermophilus; xylanase

Online: 28 June 2023 (10:12:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0213.v1

Understanding the Intricacies of Iron Overload Associated With β-Thalassemia: A Comprehensive Review

Subhangi Basu, Motiur Rahaman, Tuphan Kanti Dolai, Praphulla Chandra Shukla, Nishant Chakravorty

Subject: Medicine And Pharmacology, Hematology Keywords: β-thalassemia; iron overload; iron chelators; TDT; NTDT

Online: 2 June 2023 (14:27:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1382.v1

Prospective Evaluation of Fetal Hemoglobin Expression in Maternal Erythrocytes: an Analysis of a Cohort of 345 Parturients

Laurence Blain, Christian Watier, Xiaoduan Weng, Andre Masse, Marie-Josée Bédard, Nazila Bettache, Florence Weber, Michele Mahone, Stéphanie Forte, Vincent-Philippe Lavallée, Pierre-Olivier Gaudreau, Michael J. Newmarch, Denis Soulières

Subject: Medicine And Pharmacology, Hematology Keywords: Fetal hemoglobin; pregnancy; glycosylated hemoglobin; HbA1C; β-HCG

Online: 19 May 2023 (05:17:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0986.v1

Substituent-Controllable Cascade Regioselective Annulation of β-Enaminones with N-Sulfonyl Triazoles for Modular Access to Imidazoles and Pyrroles

Hua Wang, Tongtong Zhou, Mengdi Wu, Qingqing Ye, Xinwei He

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: annulation; β-enaminones; imidazoles; pyrroles; N-sulfonyl trizaoles

Online: 15 May 2023 (07:16:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0387.v1

Inclusion Complex of Iloperidone with Sulfobutyl Ether Beta-Cyclodextrin: Characterization and Dissolution Studies

Rupali Sanjay Bhadale, Vaishali Yogesh Londhe

Subject: Medicine And Pharmacology, Pharmacy Keywords: β-cyclodextrin; binary complex; antipsychotic drug; dissolution studies

Online: 15 March 2021 (13:44:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0610.v1

The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepatic Metabolism

Caroline Geisler, Benjamin Renquist

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: GPR109a; β-OH butyrate; niacin; metabolic homeostasis; liver

Online: 27 August 2020 (10:32:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0516.v1

Synthesis and Biological Evaluation of 3-Substituted-4-(quinoxalin-6-yl) Pyrazoles as Selective ALK5 Inhibitors

Li-Min Zhao, Zhen Guo, Yi-Jie Xue, Jun Zhe Min, Wen-Jing Zhu, Xiang-Yu Li, Hu-Ri Piao, Cheng Hua Jin

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: ALK5 inhibitor; TGF-β; kinase assay; selectivity; docking

Online: 30 August 2018 (05:52:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0072.v1

Specnvezhenide Decreases Interleukin-1β-Induced Inflammation on Rat Chondrocytes via NF-κB and wnt/β-Catenin Pathways and Reduces Joint Destruction in Osteoarthritic Rats

Chiyuan Ma, Jisheng Ran, Kai Xu, Langhai Xu, Yute Yang, Miao Sun, An Liu, Shigui Yan, Lidong Wu

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Specnvezhenide; osteoarthritis; chondrocyte; NF-κB; wnt/β-catenin

Online: 16 June 2017 (04:20:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0047.v1

Detection of 17 β-estradiol in Environmental Estrogen Pollution and in Women’s Health Care Using a Single-Use, Cost Effective Biosensor Based on Differential Pulse Voltammetry (DPV)

Yifan Dai, Chung chiun Liu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: 17 β-estradiol; estrogen pollution; female reproduction; DPV

Online: 8 March 2017 (05:39:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0787.v1

A Highly Homogeneous Airborne Fungal Community Around a Copper Open-Pit Mine Reveals a Poor Contribution by the Local Aerosolization of Particles

Sebastián Fuentes-Alburquenque, Victoria Olivencia Suez, Omayra Aguilera, Blanca Águila, Luis Rojas Araya, Dinka Mandakovic

Subject: Environmental And Earth Sciences, Ecology Keywords: microbial community; diversity; air; fungi; bioaerosol

Online: 11 April 2024 (08:03:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1642.v1

Shrews (Soricidae) and Viruses Identified in Shrews

Huan-Yu Gong, Rui-Xu Chen, Su-Mei Tan, Xiu Wang, Ji-Ming Chen, Yuan-Long Zhang, Ming Liao

Subject: Biology And Life Sciences, Virology Keywords: shrew; virus; diversity; domestic animal; human

Online: 21 December 2023 (10:25:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0860.v1

Equity, Diversity, and Inclusion Strategies in Engineering and Computer Science

Adan Amer, Gaganpreet Sidhu, Maria Isabel Ramirez Alvarez, Juan Antonio Lopez Ramos, Seshasai Srinivasan

Subject: Computer Science And Mathematics, Software Keywords: Equity; Diversity; Inclusion; strategies; priority areas

Online: 12 December 2023 (10:23:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0945.v1

Metataxonomic Analysis of Bacterial Diversity in Pigeon Pea after Soaking in Water

Yuni Sine, Donny Widianto, Yekti Asih Purwestri, Byong H. Lee, Widodo Widodo

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: pigeon pea; bacterial diversity; metataxonomic analysis

Online: 16 October 2023 (13:15:21 CEST)

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: With the increase in demand for non-dairy starter cultures and probiotic bacteria as carriers, the use of legumes (also called pulses) as an alternative has gained momentum. In this study, we investigated the diversity of bacterial communities in samples of pigeon pea (Cajanus cajan L. Millsp.) soaked in water for 12 h and 24 h. We soaked 500 g of pigeon pea in sterile distilled water at room temperature (± 25 °C) for 12 h and 24 h; 10 mL of the soaking water was then collected to measure the bacterial diversity using a metataxonomic analysis. The V1–V9 regions on the 16S ribosomal RNA gene were amplified using 27F and 1492R primers under specific polymerase chain reaction conditions for the bacterial identification. Genomic DNA (130 ng) was sequenced on a R9.4 flow cell by Oxford Nanopore Technologies using a GridION sequencer. Library preparations were initiated using a Native Barcoding Kit 24 V14 (SQK-NBD114.24). Primary data were acquired using MinKNOW version 22.05.7. A total of 13 bacterial families and 89 genera were identified in the pigeon pea sample soaked for 12 h; 26 families and 90 genera were identified in the pigeon pea sample soaked for 24 h. Among the bacterial families identified, the five predominant families in both samples were Enterobacteriaceae, Erwiniaceae, Yersiniaceae, Pectobacteriaceae, and Lactobacillaceae. According to the relative abundance of the identified bacterial genera, the following nine genera were predominant in both samples: Enterobacter, Klebsiella, Citrobacter, Pantoea, Kosakonia, Pseudoenterobacter, Pluralibacter, Leclercia, and Kluyvera. At a genus level, a slight increase in the abundance of Klebsiella, Kosakonia, and Pluralibacter and a slight decrease in the abundance of Citrobacter were observed after prolonged incubation from 12 h to 24 h. The values of five diversity indices revealed that the sample soaked in water for 24 h had a richer bacterial abundance and diversity than the 12 h sample. Shannon and Simpson values revealed a higher bacterial diversity in the sample collected at 24 h than the sample collected at 12 h. Species observations and abundance-based coverage estimator (ACE) values demonstrated that the sample collected at 24 h harbored a higher bacterial richness than the sample collected at 12 h. These findings indicated that the bacterial diversity in the pigeon pea samples increased with the soaking time. The bacterial communities during the soaking of the pigeon pea samples were dominated by the Enterobacteriaceae family and Enterobacter genus. The presence of bacterial genera such as Lacticaseibacillus, Lentilactobacillus, and Secundilactobacillus was notable because of their importance as starter cultures for fermented plant-based milk products, including pigeon pea beverages for lactose-intolerant individuals or individuals with malnutrition.

Preprint ARTICLE | doi:10.20944/preprints202310.0419.v1

Enhancing Tree Health through Improved Microbial Biodiversity in Soil

Vinesh Prasad, Daniel Cole

Subject: Environmental And Earth Sciences, Soil Science Keywords: soil health; mirobilogy; diversity; tree health

Online: 8 October 2023 (04:33:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1064.v1

Culture, Gender, and Business

EMMANUEL ADEYEMI

Subject: Arts And Humanities, History Keywords: culture; gender; business; organization; religion; diversity

Online: 18 September 2023 (05:30:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0692.v1

Functional and Species Diversity across Disturbance Levels and Environmental Variables in Yayu Coffee Forest Biosphere Reserve, Southwest Ethiopia

Ferede Abuye Jeldu, Motuma Tolera Feyisa, Teshale Woldeamanuel

Subject: Biology And Life Sciences, Forestry Keywords: biosphere reserve; disturbance; functional diversity; zonation

Online: 11 July 2023 (10:55:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1425.v1

Anaemia in Preschool-Aged Children in DR. Congo: Finding from a Nationally Representative Survey

Ngianga II (Shadrack) Kandala

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Haemoglobin; Anaemia; Dietary, Diversity; Random-effect

Online: 19 May 2023 (10:06:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1234.v1

Butterflies of the Neotropical Seasonally Dry Forest of Montes de María (Sucre, Colombia): What do they Tell us about the Intermediate Disturbance Hypothesis?

Yarlenis L Mercado-Gómez, Jorge D Mercado-Gómez, Carlos E Giraldo-Sánchez

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: structure; diversity; anthropic disturbance; conservation; Lepidoptera

Online: 17 May 2023 (10:38:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0879.v1

Glucosinolate Diversity Analysis in Choy sum (Brassica rapa subsp chinensis var parachinensis) Germplasms for Functional Foods Breeding

Seong-Hoon Kim, Parthiban Subramanian, Bum-Soo Hahn

Subject: Biology And Life Sciences, Food Science And Technology Keywords: glucosinolate; germplasm; breeding; anticancer; genebank; diversity

Online: 12 May 2023 (04:27:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0206.v1

Testing White’s Floristic Impoverishment Hypothesis in the Forest-Savanna Transition Zones of Africa

Mathew Rees, John L. Godlee, David J. Harris, Casey M. Ryan, Kyle G. Dexter

Subject: Environmental And Earth Sciences, Ecology Keywords: Africa; forest; savanna; phylogenetic; diversity; transition

Online: 4 May 2023 (06:04:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0056.v2

Women’s Participation in Leadership Roles in a Single Canadian Paramedic Service

Justin Mausz, Sarah Salvis, Dominique Arseneau-Bruneau, Elizabeth Donnelly

Subject: Social Sciences, Sociology Keywords: Emergency Medical Services; paramedics; gender; diversity

Online: 15 February 2023 (04:34:52 CET)

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Introduction: Like other public safety professions, paramedicine has historically been a male-dominated occupation, both in the demography of its workforce and in its organizational culture. Although women are increasingly choosing paramedicine as a career, participation in leadership roles remains limited. Drawing on data from a recent comprehensive mental health survey, we describe the proportion of women in leadership in a single, large, urban paramedic service in Ontario, Canada. Methods: We distributed an in-person, paper-based survey during the fall 2019 - winter 2020 Continuing Medical Education (CME) sessions. Participating paramedics completed a demographic questionnaire alongside a battery of mental health screening tools. We assessed the demography of the workforce and explored differences in employment classification, provider level (e.g., primary vs. advanced care), and participation in formal leadership roles along self-reported gender lines. Results: Out of 607 paramedics attending CME, we received 600 completed surveys, with 11 excluded for missing data, leaving 589 for analysis and a 97% response rate. Women comprised 40% of the active-duty paramedic workforce, with an average of 8 years of experience. Compared to men, women were more than twice as likely to have a university degree (Odds Ratio [OR] 2.02), but almost half as likely to practice at the Advanced Care Paramedic level (OR 0.61), and somewhat less likely to be employed full-time (OR 0.77). Women were nearly 70% less likely to hold a leadership role in the service compared to men (OR 0.36), occupying just 20% of leadership positions. Conclusion: Although paramedicine is witnessing an encouraging shift in the demography of its workforce with greater participation from women, there is still work to be done, particularly in leadership. Future research should focus on identifying and ameliorating barriers to career advancement among women and other historically underrepresented people.

Preprint ARTICLE | doi:10.20944/preprints202204.0283.v1

The Functional Biogeography of eDNA Metacommunities in the Post-fire Landscape of the Angeles National Forest

Savanah Senn, Sharmodeep Bhattacharyya, Gerald Presley, Anne E. Taylor, Jillian Ford, Brandon Jasinski, Yekaterina Badalova

Subject: Environmental And Earth Sciences, Environmental Science Keywords: molecular ecology; functional diversity; DNA sequencing

Online: 28 April 2022 (10:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0414.v1

Genotypic and Epidemiologic Profiles of Giardia duodenalis in Four Brazilian Biogeographic Regions

Deiviane Calegar, Beatriz Nunes, Kerla Monteiro, Polyanna Bacelar, Brenda Evangelista, Mayron Moraes, Jurecir Silva, Jéssica Santos, Márcio Bóia, Lauren Jaeger, Filipe Anibal Carvalho-Costa

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Giardia duodenalis; Assemblages; Epidemiology; Genetic diversity

Online: 27 January 2022 (11:18:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0560.v1

Microbial Diversity Based on Multifractal Analysis of Metagenomes

Xianhua Xie, Yuanlin Ma, Zuguo Yu, Guosheng Han

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: diversity index; multifractal; metagenome; gut mtagenome

Online: 26 July 2021 (10:04:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0349.v1

Genetic Diversity of Bemisia tabaci (Gennadius) (Hemiptera:Aleyrodidae) Colonizing Sweet Potato and Cassava in South Sudan

Beatrice Clarence Misaka, Everlyne N. Wosula, Philip W. Marchelo-d'Ragga, Trine Hvoslef-Eide, James Peter Legg

Subject: Biology And Life Sciences, Forestry Keywords: Bemisia tabaci; genetic diversity; distribution; haplotype

Online: 28 November 2019 (03:24:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0249.v1

The Yeast Atlas of Appalachia: Species and Phenotypic Diversity of Herbicide Resistance in Wild Yeast

Jordan B. Barney, Matthew J. Winans, Catherine B. Blackwood, Amaruy Pupo, Jennifer E. G. Gallagher

Subject: Biology And Life Sciences, Agricultural Science And Agronomy Keywords: Fungal diversity; Saccharomyces; genetic diversity; glyphosate-based herbicides; copper-based fungicides; RoundUp Ready™ corn; phylogenetics

Online: 17 February 2020 (15:37:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2045.v1

Influence of Enzymes Combination (α-Amylase and and β-Amylase) for Maltodextrin Production from Cassava Solid Waste (Onggok)

Aniek Sri Handayani, Noverra Mardhatillah Nizardo, Jihan Nabila, Annisa Nurul Syabila

Subject: Chemistry And Materials Science, Food Chemistry Keywords: maltodextrin; dextrose equivalent; enzymatic hydrolysis; α-amylase; β-amylase

Online: 27 December 2023 (09:44:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1112.v1

Nutritional Strategies to Mitigate Post-Weaning Challenges in Pigs: A Focus on Glucans, Vitamin D, and Selenium

John V O'Doherty, Alison Dowley, Eadaoin Conway, Torres Sweeney

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: pig; weaning; β-glucans; mushrooms, vitamin D, selenium, dam

Online: 14 December 2023 (17:12:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0736.v1

Chrysin Mediates the Induction of Apoptosis in Breast Cancer Cells via the Inhibition of the WNT/β-Catenin Signaling Pathway

Sümeyra Çetinkaya

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: antiproliferation; apoptosis; breast cancer; chrysin; WNT/β-catenin pathway

Online: 11 October 2023 (13:23:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1062.v1

Impact of Enzymatic Soymilk Isoflavones Biotransformation for Improved Bioaccessibility and Antioxidant Capacity

Gabriela Alves Macedo, Cintia Rabelo Paiva Caria, Paula de Paula Menezes Barbosa, Marina Rodriges Mazine, Alessandra Gambero

Subject: Biology And Life Sciences, Food Science And Technology Keywords: isoflavones; soymilk; β-glucosidase; probiotics; gastrointestinal digestion in vitro

Online: 17 July 2023 (10:58:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0346.v1

The Effects of Low-Dose Empagliflozin on Cardiac Function and Β-Adrenoceptor Responses in a Rat Model of Streptozotocin-Induced Diabetes

Zeynep Elif Yesilyurt, Irem Karaomerlioglu, Betul Rabia Erdogan, Gaye Ozturk, Martin C. Michel, Ebru Arioglu-Inan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: β-adrenoceptor; diabetes; empagliflozin; heart; pressure-volume loop analysis

Online: 25 May 2022 (09:59:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0366.v1

Radiosensitizer Effect of β-Apopicropodophyllin Against Colorectal Cancer via Induction of Reactive Oxygen Species and Apoptosis

Na-Gyeong Lee, Jin-Hee Kwon, A-Ram Kang, Jie-Young Song, Sang-Gu Hwang, Hong-Duck Um, Joon Kim, Jong Kuk Park

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: β-Apopicropodophyllin; Radiosensitizer; Topoisomerase inhibitor; ROS, Apoptosis; Colorectal cancer

Online: 19 November 2021 (14:54:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202109.0341.v1

Effect of Anti-cancerous Compounds on Cancer Cells Extracted From Edible Mushrooms: A Review

Kannan Vignesh, Moumita Ghosh

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Edible Mushrooms; anti-cancerous; bioactive compounds; therapeutic; β-glucan

Online: 20 September 2021 (15:33:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0047.v2

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC

Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; TGF-β

Online: 8 September 2021 (20:53:29 CEST)

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Working Paper ARTICLE

Dietary Lactoferrin Intervention Was Unable to Improve Cognitive Function from Both Young and Middle-Aged APPswe/PS1dE9 Transgenic Mice

Huanhuan Zhou, Guiping Wang, Lan Luo, Wei Ding, Jia-Ying Xu, Li-Qiang Qin, Zhongxiao Wan

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Alzheimer’s disease; lactoferrin; cognitive function; gut microbiota; amyloid β

Online: 17 February 2020 (01:00:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints201910.0272.v1

Provitamin A Biofortification of Durum Wheat through a TILLING Approach

Francesco Sestili, Maria Dolores Garcia-Molina, Gianluca Gambacorta, Romina Beleggia, Ermelinda Botticella, Pasquale De Vita, Daniel-Valentin Savatin, Stefania Masci, Domenico Lafiandra

Subject: Biology And Life Sciences, Plant Sciences Keywords: durum wheat; β-carotene; TILLING; biofortification; vitamin A deficiency

Online: 24 October 2019 (05:28:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201704.0135.v1

Regulation of G Protein-Coupled Receptors by Ubiquitination

Kamila Skieterska, Pieter Rondou, Kathleen Van Craenenbroeck

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GPCR; ubiquitination; β-arrestin; deubiquitinating enzyme; E3 ubiquitin ligase

Online: 21 April 2017 (06:23:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0037.v1

Antioxidant Activity and Isolation of β-Sitosterol from Ethyl Acetate Extract of Aerial Parts of Consolida orientalis

Abbas Ali Dehpour

Subject: Biology And Life Sciences, Plant Sciences Keywords: Consolida orientalis; ethyl acetate extract; antioxidant activity; β-sitosterol

Online: 9 September 2016 (11:18:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1032.v1

Agronomic and Economic Evaluation of Tree Species in Agroforestry Systems with Cocoa (Theobroma cacao L.) in Amazonas

Nixon Huaman Haro, Jerry Bryan Lopezhaya Mendoza, Angel James Medina Medina, Jhon Antony Zabaleta Santisteban, Daniel Tineo Flores, Lily Juarez-Contreras, Malluri Goñas, Manuel Oliva-Cruz

Subject: Biology And Life Sciences, Forestry Keywords: Peru; cocoa; diversity; agroforestry systems; economic analysis

Online: 18 March 2024 (16:12:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1144.v1

Linking Wetland Ecosystem Services to Fish Genetic Resources with Special Reference to Hilsa Shad (Tenualosa ilisha): A Novel Study from Northeastern Bangladesh

Atiqur Rahman Sunny, Md. Arifur Rahman, Md. Nazmul Hasan, Jeba Faizah Rahman, Sharif Ahmed Sazzad, Md. Faruque Miah, Md. Ashrafuzzaman, Shamsul Haque Prodhan

Subject: Biology And Life Sciences, Aquatic Science Keywords: Wetland; Ecosystem services; Genetic diversity; Hilsa; Bangladesh

Online: 20 February 2024 (12:44:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0127.v1

The Family Fabaceae in northeastern Mexico (Subfamily Caesalpinioideae, Mimosoideae Clade, Tribes Mimoseae, Acacieae, and Ingeae)

Eduardo Estrada-Castillón, José Ángel Villarreal-Quintanilla, Gerardo Cuéllar-Rodríguez, Juan Antonio Encina-Domínguez, José Guadalupe Martínez-Ávalos, Arturo Mora-Olivo, Jaime Sánchez-Salas

Subject: Biology And Life Sciences, Plant Sciences Keywords: Leguminosae; Clade Mimosoideae; taxonomy; diversity; northeastern Mexico

Online: 3 January 2024 (03:54:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0029.v1

Genomics of Re-emergent Aeromonas salmonicida in Atlantic Salmon Outbreaks

Marcos Godoy, Marco Montes de Oca, Rudy Suarez, Alexis Martinez, Juan Pablo Pontigo, Diego Caro, Karina Kusch, Harry Bohle, Molly Kibenge, Frederick Kibenge, Sion Bayliss

Subject: Biology And Life Sciences, Aquatic Science Keywords: furunculosis; Aeromonas salmonicida; Salmo salar; genomic diversity

Online: 1 December 2023 (05:31:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1261.v1

Fungal Diversity and Distribution in the Biodiversity Hotspots of the Western Himalayas

Neelesh Yadav, Shrey Rakholia, Naseem Ali, Reuven Yosef

Subject: Biology And Life Sciences, Life Sciences Keywords: Fungi; Diversity; Western Himalayan region; PCA; ANOVA

Online: 19 September 2023 (08:28:18 CEST)

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