The University of Guayaquil, which shares the same name as the city where it is located, faces the challenge of transforming its image for the XXI century. It was deemed necessary to identify details about the urban evolution of the historic link with the city, in relation to the changes produced by the project’s siting and its direct area of influence. The goal is to integrate the main university campus within a framework which guarantees sustainability and allows innovation in the living lab. To achieve this, the action research method was applied, focused on participation and the logic framework. For the diagnosis, proposal, and management model, integrated working groups were organized with internal users such as professors, students, and university authorities, and external actors such as residents, the local business community, Guayaquil city council, and the Governorate of Guayas. As result of the diagnosis, six different analysis dimensions were established which correspond to the new urban agenda for the future campus: compactness, inclusiveness, resilience, sustainability, safety and participation. As a proposal, the urban design integrates the analysis dimensions whose financing and execution are given by the Town Hall, at the same time the Governorate integrates the campus with its network of community police headquarters.