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Submitted:
03 February 2025
Posted:
04 February 2025
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Background: Ionizing radiation-induced cardiac toxicity is a growing concern due to the increased use of radiation therapy (RT) in cancer treatment. This study investigated the cardioprotective effects of propolis, a natural antioxidant, against cranial irradiation-induced oxidative damage. Materials and Methods: A total of 32 Sprague-Dawley rats were divided into 4 groups (n=8/group): (1) a control group receiving 1 ml of saline orally for 10 days, (2) a propolis control group receiving propolis dissolved in dimethyl sulfoxide daily via oral gavage for 10 days, (3) an ionizing radiation (IR) group exposed to 5 Gray (Gy) of gamma radiation for 10 days, and (4) an IR+ propolis group receiving 80 mg of propolis daily alongside IR treatment for 10 days. Cardiac tissue was excised for biochemical analyses. Oxidative stress was assessed by measuring lipid hydroperoxide, total oxidant status (TOS), and oxidative stress index. Antioxidant capacity was evaluated through total antioxidant status (TAS), arylesterase, ceruloplasmin, paraoxonase, and total sulfhydryl (total-SH). Results: The IR group exhibited significantly elevated oxidative stress markers compared to the control group, while propolis supplementation effectively reduced their levels.
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