Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Quantitative Analysis of the Steroidal Calcitriol-Mediated Regulation of the Serological Components Responsible for IDA and TSH Disorders in Reproductive and Nonproductive Women

Version 1 : Received: 30 September 2021 / Approved: 1 October 2021 / Online: 1 October 2021 (11:32:58 CEST)

How to cite: Al Azad, S.; Ahmed, S.; Biswas, P.; Mia, M.A.R.; Farjana, M.; Arshe, F.A.; Mily, S.J.; Ankhi, A.B.; Shaikat, M.M.; Sultana, S.; Mawa, K.; Naim, Z.; Rahman, M.A.; Kim, B. Quantitative Analysis of the Steroidal Calcitriol-Mediated Regulation of the Serological Components Responsible for IDA and TSH Disorders in Reproductive and Nonproductive Women. Preprints 2021, 2021100007 (doi: 10.20944/preprints202110.0007.v1). Al Azad, S.; Ahmed, S.; Biswas, P.; Mia, M.A.R.; Farjana, M.; Arshe, F.A.; Mily, S.J.; Ankhi, A.B.; Shaikat, M.M.; Sultana, S.; Mawa, K.; Naim, Z.; Rahman, M.A.; Kim, B. Quantitative Analysis of the Steroidal Calcitriol-Mediated Regulation of the Serological Components Responsible for IDA and TSH Disorders in Reproductive and Nonproductive Women. Preprints 2021, 2021100007 (doi: 10.20944/preprints202110.0007.v1).

Abstract

Anemia and thyroid disorders are global health issues that affect all ages but are more apparent in women. In this case, some serological components responsible for IDA and TSH disorders in women have been found actively regulated through a complex steroidal-calcitriol mediated pathway. This research has been investigated the correlation between Calcitriol and the serological components responsible for IDA and TSH disorders in childbearing and non-child-bearing women of different health conditions. Experimental sampling from 452 women suffering from both IDA and TSH disorders were taken, aged between 0 and 70 years. Serological parameters, such as iron, total iron-binding capacity and ferritin, were assessed for IDA profiling, whereas thyroid-stimulating hormone and free thyroxin were for TSH profiling based on the individual’s serum calcitriol status. The resulted serological data were interpreted using sophisticated computer programming language and algorithms for quantitative biochemical analysis. The study resulted in a significant correlation between FT4 and Calcitriol (P<0.0001) for all age groups. TSH also showed strong interactions with the fluctuation of calcitriol level (P<0.0001), except for the children aged below 10 years (P<0.063). The iron, TIBC, TSH, and FT4 showed phenomenal regulation with the steroidal-calcitriol concentration for congenital patients. Unlike the others, ferritin has a substantial connection with Calcitriol (P<0.0064) fluctuation in the serum. To ratify, the concentrations of TSH, FT4, iron, TIBC, and ferritin were found to be significantly interconnected in terms of serum calcitriol level in women suffering from IDA and TSH disorders simultaneously. To understand the accuracy and efficacy of the Calcitriol in IDA and TSH disorders, some other inflammatory markers and parathyroid hormone analysis are need in future studies, besides a large number of samples.

Keywords

TSH disorder; IDA; TIBC; ferritin; FT4; Calcitriol mediated regulation; reproductive and non-reproductive women; quantitative serological assessment

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