Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Microfluidics as a Novel Technique for Tuberculosis: From Di-agnostics to Drug Discovery

Version 1 : Received: 28 September 2021 / Approved: 29 September 2021 / Online: 29 September 2021 (11:34:04 CEST)

A peer-reviewed article of this Preprint also exists.

Molloy, A.; Harrison, J.; McGrath, J.S.; Owen, Z.; Smith, C.; Liu, X.; Li, X.; Cox, J.A.G. Microfluidics as a Novel Technique for Tuberculosis: From Diagnostics to Drug Discovery. Microorganisms 2021, 9, 2330. Molloy, A.; Harrison, J.; McGrath, J.S.; Owen, Z.; Smith, C.; Liu, X.; Li, X.; Cox, J.A.G. Microfluidics as a Novel Technique for Tuberculosis: From Diagnostics to Drug Discovery. Microorganisms 2021, 9, 2330.

Journal reference: Microorganisms 2021, 9, 2330
DOI: 10.3390/microorganisms9112330

Abstract

Tuberculosis (TB) remains a global healthcare crisis with an estimated 10 million new cases and 1.4 million deaths per year TB is caused by infection with the major human pathogen Mycobacte-rium tuberculosis, which is difficult to rapidly diagnose and treat. There is an urgent need for new methods of diagnosis, sufficient in vitro models which capably mimic all physiological condi-tions of the infection, and high-throughput drug screening platforms. Microfluidic-based tech-niques provide single-cell analysis which reduces experimental time, the cost of reagents, and have been extremely useful for gaining insight into monitoring microorganisms. This review out-lines the field of microfluidics and discusses the use of this novel technique so far in M. tuberculo-sis diagnostics, research methods, and drug discovery platforms. The practices of microfluidics have promising future applications for diagnosing and treating TB.

Keywords

Tuberculosis; Mycobacterium; Diagnostics; Drug Discovery; Antibiotics; Antimicrobial Re-sistance; Microfluidics; Single-Cell Analysis; Bioengineered Models

Subject

LIFE SCIENCES, Microbiology

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