Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Microfluidics as a Novel Technique for Tuberculosis: From Di-agnostics to Drug Discovery

Antonia Molloy
,
James Harrison
,
John McGrath
,
Zachary Owen
ORCID logo ,
Clive Smith
,
Xin Liu
,
Xin Li
,
Jonathan A.G. Cox
* ORCID logo
Version 1 : Received: 28 September 2021 / Approved: 29 September 2021 / Online: 29 September 2021 (11:34:04 CEST)

A peer-reviewed article of this Preprint also exists.

Molloy, A.; Harrison, J.; McGrath, J.S.; Owen, Z.; Smith, C.; Liu, X.; Li, X.; Cox, J.A.G. Microfluidics as a Novel Technique for Tuberculosis: From Diagnostics to Drug Discovery. Microorganisms 2021, 9, 2330. Molloy, A.; Harrison, J.; McGrath, J.S.; Owen, Z.; Smith, C.; Liu, X.; Li, X.; Cox, J.A.G. Microfluidics as a Novel Technique for Tuberculosis: From Diagnostics to Drug Discovery. Microorganisms 2021, 9, 2330.

Abstract

Tuberculosis (TB) remains a global healthcare crisis with an estimated 10 million new cases and 1.4 million deaths per year TB is caused by infection with the major human pathogen Mycobacte-rium tuberculosis, which is difficult to rapidly diagnose and treat. There is an urgent need for new methods of diagnosis, sufficient in vitro models which capably mimic all physiological condi-tions of the infection, and high-throughput drug screening platforms. Microfluidic-based tech-niques provide single-cell analysis which reduces experimental time, the cost of reagents, and have been extremely useful for gaining insight into monitoring microorganisms. This review out-lines the field of microfluidics and discusses the use of this novel technique so far in M. tuberculo-sis diagnostics, research methods, and drug discovery platforms. The practices of microfluidics have promising future applications for diagnosing and treating TB.

Keywords

Tuberculosis; Mycobacterium; Diagnostics; Drug Discovery; Antibiotics; Antimicrobial Re-sistance; Microfluidics; Single-Cell Analysis; Bioengineered Models

Subject

Biology and Life Sciences, Immunology and Microbiology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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