Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Metabolic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry

Nnenna Elebo
,
Jones Omoshoro-Jones
,
Pascaline Fonteh-Fru
,
John Devar
,
Christiaan De Wet van Zyl
,
Barend Christiaan Vorster
ORCID logo ,
Martin Smith
,
Stefano Cacciatore
ORCID logo ,
Luiz F. Zerbini
ORCID logo ,
Geoffrey Candy
,
Ekene Emmanuel Nweke
* ORCID logo
Version 1 : Received: 9 August 2021 / Approved: 10 August 2021 / Online: 10 August 2021 (14:08:27 CEST)

A peer-reviewed article of this Preprint also exists.

Elebo, N.; Omoshoro-Jones, J.; Fru, P.N.; Devar, J.; De Wet van Zyl, C.; Vorster, B.C.; Smith, M.; Cacciatore, S.; Zerbini, L.F.; Candy, G.; Nweke, E.E. Serum Metabolomic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry. Metabolites 2021, 11, 663. Elebo, N.; Omoshoro-Jones, J.; Fru, P.N.; Devar, J.; De Wet van Zyl, C.; Vorster, B.C.; Smith, M.; Cacciatore, S.; Zerbini, L.F.; Candy, G.; Nweke, E.E. Serum Metabolomic and Lipoprotein Profiling of Pancreatic Ductal Adenocarcinoma Patients of African Ancestry. Metabolites 2021, 11, 663.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a characteristic dysregulated metabolism. Abnormal clinicopathological features linked to defective metabolic and inflammatory response pathways can induce PDAC development and progression. In this study, we investigated the metabolites and lipoproteins profiles of PDAC patients of African ancestry. Nuclear Magnetic Resonance (NMR) spectroscopy was conducted on serum obtained from consenting individuals (34 PDAC, 6 Chronic Pancreatitis, and 6 healthy participants). Seventy-five signals were quantified from each NMR spectrum. The Liposcale test was used for lipoprotein characterization. Spearman’s correlation and Kapan Meier tests were conducted for correlation and survival analyses respectively. In our patient cohort, the results demonstrated that levels of metabolites involved in the glycolytic pathway increased with the tumour stage. Raised ethanol and 3-hydroxybutyrate were independently correlated with a shorter patient survival time, irrespective of tumour stage. Furthermore, increased levels of bilirubin resulted in an abnormal lipoprotein profile in PDAC patients. Additionally, we observed that the levels of a panel of metabolites (such as glucose, lactate) and lipoproteins correlated with those of inflammatory markers. Taken together, the metabolic phenotype can help distinguish PDAC severity and be used in predicting patient survival and in informing treatment intervention.

Keywords

Pancreatic Ductal Adenocarcinoma; metabolites; cholestatic (obstructive) jaundice; lipoprotein; inflammation; tumour stages

Subject

Biology and Life Sciences, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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