Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries

How to cite: Han, I.W.; Park, J.; Park, E.Y.; Yoon, S.J.; Jin, G.; Hwang, D.W.; Jiang, K.; Kwon, W.; Xu, X.; Heo, J.S.; Fu, D.; Lee, W.; Bai, X.; Yoon, Y.; Yang, Y.; Ahn, K.S.; Yuan, C.; Lee, H.K.; Sun, B.; Park, E.K.; Lee, S.E.; Kang, S.; Lou, W.H.; Park, S. Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries. Preprints 2021, 2021070527. https://doi.org/10.20944/preprints202107.0527.v1 Han, I.W.; Park, J.; Park, E.Y.; Yoon, S.J.; Jin, G.; Hwang, D.W.; Jiang, K.; Kwon, W.; Xu, X.; Heo, J.S.; Fu, D.; Lee, W.; Bai, X.; Yoon, Y.; Yang, Y.; Ahn, K.S.; Yuan, C.; Lee, H.K.; Sun, B.; Park, E.K.; Lee, S.E.; Kang, S.; Lou, W.H.; Park, S. Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries. Preprints 2021, 2021070527. https://doi.org/10.20944/preprints202107.0527.v1

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MDPI and ACS Style

Han, I.W.; Park, J.; Park, E.Y.; Yoon, S.J.; Jin, G.; Hwang, D.W.; Jiang, K.; Kwon, W.; Xu, X.; Heo, J.S.; Fu, D.; Lee, W.; Bai, X.; Yoon, Y.; Yang, Y.; Ahn, K.S.; Yuan, C.; Lee, H.K.; Sun, B.; Park, E.K.; Lee, S.E.; Kang, S.; Lou, W.H.; Park, S. Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries. Preprints 2021, 2021070527. https://doi.org/10.20944/preprints202107.0527.v1

APA Style

Han, I.W., Park, J., Park, E.Y., Yoon, S.J., Jin, G., Hwang, D.W., Jiang, K., Kwon, W., Xu, X., Heo, J.S., Fu, D., Lee, W., Bai, X., Yoon, Y., Yang, Y., Ahn, K.S., Yuan, C., Lee, H.K., Sun, B., Park, E.K., Lee, S.E., Kang, S., Lou, W.H., & Park, S. (2021). Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries. Preprints. https://doi.org/10.20944/preprints202107.0527.v1

Chicago/Turabian Style

Han, I.W., Wen hui Lou and Sang-Jae Park. 2021 "Fate of Surgical Patients with Small Nonfunctioning Pancreatic Neuroendocrine Tumors: An International Study Using Multi-Institutional Registries" Preprints. https://doi.org/10.20944/preprints202107.0527.v1

Abstract

Several treatment guidelines for sporadic, nonmetastatic nonfunctioning neuroendocrine tumors of the pancreas (NF-pNETs) have recommended resection, however, tumors ≤ 2 cm do not necessarily need surgery. This study aimed to establish a surgical treatment plan for NF-pNETs ≤ 2 cm. From 2000 to 2017, 483 patients who underwent resection for NF-pNETs ≤ 2cm in 18 institutions from Korea and China were enrolled and their medical records were reviewed. Median age was 56 (range 16- 80) years. The 10-year overall survival rate (10Y-OS) and recurrence-free survival rate (10Y-RFS) were 89.8 and 93.1%, respectively. In multivariable analysis, tumor size (> 1.5cm; p = 0.001) and nodal metastasis (p = 0.013) were independent adverse prognostic factors for OS. Perineural invasion (p = 0.008) and high Ki-67 index (≥3%; p < 0.001) were independent prognostic factors for poor RFS. NF-pNETs ≤ 2 cm showed unfavorable prognosis after resection when the tumor was larger than 1.5cm, Ki-67 index ≥ 3%, or nodal metastasis was present. NF-pNET patients with tumors ≤ 1.5cm can be observed if the preoperative Ki-67 index is under 3%, and if nodal metastasis is not suspected in preoperative radiologic studies. These findings support the clinical use to make decision about small NF-pNETs.

Keywords

Nonfunctioning neuroendocrine tumor of pancreas; Prognosis; Resection; Risk factors

Subject

Medicine and Pharmacology, Immunology and Allergy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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